                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  ANTI-BODY-GUIDED PCSK9-MIMICKING IMMUNOGENS LACKING 9-RESIDUE 
       SEQUENCE OVERLAP WTH HUMAN PROTEINS

<130>  758174

<150>  US 63/132,640
<151>  2020-12-31

<160>  164   

<170>  PatentIn version 3.5

<210>  1
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  2
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Leu Glu Val Leu Phe Gln Gly 
            420                 425                 430         


Pro Ala Thr Gly Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg 
        435                 440                 445             


Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly 
    450                 455                 460                 


Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala 
465                 470                 475                 480 


Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His 
                485                 490                 495     


His Gly Ile Gly Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr 
            500                 505                 510         


Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile 
        515                 520                 525             


Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser 
    530                 535                 540                 


His Tyr Ile Arg Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His 
545                 550                 555                 560 


Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala 
                565                 570                 575     


Phe Cys Cys His Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His 
            580                 585                 590         


Gln Ser Glu Phe Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp 
        595                 600                 605             


Thr Leu Thr Gly Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala 
    610                 615                 620                 


Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp 
625                 630                 635                 640 


Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp 
                645                 650                 655     


Gln Gln Ser Asn Asn Asn His Glu Gln Asn Thr Gly Gly Leu Val Pro 
            660                 665                 670         


Arg Gly Ser His His His His His His Ser Ala Trp Ser His Pro Gln 
        675                 680                 685             


Phe Glu Lys 
    690     


<210>  3
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Leu Glu Val Leu Phe Gln 
            420                 425                 430         


Gly Pro Thr Gly Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg 
        435                 440                 445             


Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly 
    450                 455                 460                 


Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala 
465                 470                 475                 480 


Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His 
                485                 490                 495     


His Gly Ile Gly Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr 
            500                 505                 510         


Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile 
        515                 520                 525             


Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser 
    530                 535                 540                 


His Tyr Ile Arg Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His 
545                 550                 555                 560 


Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala 
                565                 570                 575     


Phe Cys Cys His Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His 
            580                 585                 590         


Gln Ser Glu Phe Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp 
        595                 600                 605             


Thr Leu Thr Gly Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala 
    610                 615                 620                 


Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp 
625                 630                 635                 640 


Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp 
                645                 650                 655     


Gln Gln Ser Asn Asn Asn His Glu Gln Asn Thr Gly Gly Leu Val Pro 
            660                 665                 670         


Arg Gly Ser His His His His His His Ser Ala Trp Ser His Pro Gln 
        675                 680                 685             


Phe Glu Lys 
    690     


<210>  4
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Leu Glu Val Leu Phe 
            420                 425                 430         


Gln Gly Pro Gly Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg 
        435                 440                 445             


Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly 
    450                 455                 460                 


Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala 
465                 470                 475                 480 


Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His 
                485                 490                 495     


His Gly Ile Gly Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr 
            500                 505                 510         


Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile 
        515                 520                 525             


Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser 
    530                 535                 540                 


His Tyr Ile Arg Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His 
545                 550                 555                 560 


Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala 
                565                 570                 575     


Phe Cys Cys His Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His 
            580                 585                 590         


Gln Ser Glu Phe Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp 
        595                 600                 605             


Thr Leu Thr Gly Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala 
    610                 615                 620                 


Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp 
625                 630                 635                 640 


Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp 
                645                 650                 655     


Gln Gln Ser Asn Asn Asn His Glu Gln Asn Thr Gly Gly Leu Val Pro 
            660                 665                 670         


Arg Gly Ser His His His His His His Ser Ala Trp Ser His Pro Gln 
        675                 680                 685             


Phe Glu Lys 
    690     


<210>  5
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Leu Glu Val Leu 
            420                 425                 430         


Phe Gln Gly Pro Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg 
        435                 440                 445             


Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly 
    450                 455                 460                 


Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala 
465                 470                 475                 480 


Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His 
                485                 490                 495     


His Gly Ile Gly Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr 
            500                 505                 510         


Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile 
        515                 520                 525             


Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser 
    530                 535                 540                 


His Tyr Ile Arg Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His 
545                 550                 555                 560 


Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala 
                565                 570                 575     


Phe Cys Cys His Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His 
            580                 585                 590         


Gln Ser Glu Phe Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp 
        595                 600                 605             


Thr Leu Thr Gly Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala 
    610                 615                 620                 


Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp 
625                 630                 635                 640 


Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp 
                645                 650                 655     


Gln Gln Ser Asn Asn Asn His Glu Gln Asn Thr Gly Gly Leu Val Pro 
            660                 665                 670         


Arg Gly Ser His His His His His His Ser Ala Trp Ser His Pro Gln 
        675                 680                 685             


Phe Glu Lys 
    690     


<210>  6
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Gly Ser Gly Leu Glu Val Leu 
            420                 425                 430         


Phe Gln Gly Pro Gly Ser Gly Ala Thr Gly Glu Lys Leu Leu Cys Arg 
        435                 440                 445             


Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val 
    450                 455                 460                 


Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser 
465                 470                 475                 480 


Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln 
                485                 490                 495     


Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr Ala 
            500                 505                 510         


Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala 
        515                 520                 525             


Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln 
    530                 535                 540                 


Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln 
545                 550                 555                 560 


Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu 
                565                 570                 575     


Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys 
            580                 585                 590         


His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu Val 
        595                 600                 605             


Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His 
    610                 615                 620                 


Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile 
625                 630                 635                 640 


Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys 
                645                 650                 655     


Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn 
            660                 665                 670         


Thr Gly Gly Leu Val Pro Arg Gly Ser His His His His His His Ser 
        675                 680                 685             


Ala Trp Ser His Pro Gln Phe Glu Lys 
    690                 695         


<210>  7
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Gly Ser Gly Leu Glu Val 
            420                 425                 430         


Leu Phe Gln Gly Pro Gly Ser Gly Thr Gly Glu Lys Leu Leu Cys Arg 
        435                 440                 445             


Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val 
    450                 455                 460                 


Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser 
465                 470                 475                 480 


Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln 
                485                 490                 495     


Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr Ala 
            500                 505                 510         


Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala 
        515                 520                 525             


Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln 
    530                 535                 540                 


Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln 
545                 550                 555                 560 


Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu 
                565                 570                 575     


Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys 
            580                 585                 590         


His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu Val 
        595                 600                 605             


Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His 
    610                 615                 620                 


Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile 
625                 630                 635                 640 


Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys 
                645                 650                 655     


Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn 
            660                 665                 670         


Thr Gly Gly Leu Val Pro Arg Gly Ser His His His His His His Ser 
        675                 680                 685             


Ala Trp Ser His Pro Gln Phe Glu Lys 
    690                 695         


<210>  8
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Ser Gly Leu Glu 
            420                 425                 430         


Val Leu Phe Gln Gly Pro Gly Ser Gly Gly Glu Lys Leu Leu Cys Arg 
        435                 440                 445             


Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val 
    450                 455                 460                 


Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser 
465                 470                 475                 480 


Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln 
                485                 490                 495     


Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr Ala 
            500                 505                 510         


Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala 
        515                 520                 525             


Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln 
    530                 535                 540                 


Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln 
545                 550                 555                 560 


Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu 
                565                 570                 575     


Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys 
            580                 585                 590         


His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu Val 
        595                 600                 605             


Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His 
    610                 615                 620                 


Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile 
625                 630                 635                 640 


Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys 
                645                 650                 655     


Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn 
            660                 665                 670         


Thr Gly Gly Leu Val Pro Arg Gly Ser His His His His His His Ser 
        675                 680                 685             


Ala Trp Ser His Pro Gln Phe Glu Lys 
    690                 695         


<210>  9
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Gly Ser Gly Leu 
            420                 425                 430         


Glu Val Leu Phe Gln Gly Pro Gly Ser Gly Glu Lys Leu Leu Cys Arg 
        435                 440                 445             


Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val 
    450                 455                 460                 


Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser 
465                 470                 475                 480 


Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln 
                485                 490                 495     


Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr Ala 
            500                 505                 510         


Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala 
        515                 520                 525             


Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln 
    530                 535                 540                 


Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln 
545                 550                 555                 560 


Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu 
                565                 570                 575     


Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys 
            580                 585                 590         


His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu Val 
        595                 600                 605             


Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His 
    610                 615                 620                 


Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile 
625                 630                 635                 640 


Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys 
                645                 650                 655     


Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn 
            660                 665                 670         


Thr Gly Gly Leu Val Pro Arg Gly Ser His His His His His His Ser 
        675                 680                 685             


Ala Trp Ser His Pro Gln Phe Glu Lys 
    690                 695         


<210>  10
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Ser Leu Val Arg Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
            660                 665                 670         


Ile Gly Ile Thr Glu Gly Gly Leu Val Pro Arg Gly Ser His His His 
        675                 680                 685             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    690                 695                 700     


<210>  11
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Ser Leu Val Arg Phe Asn Asn Phe Thr Val Ser Phe Trp 
            660                 665                 670         


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Gly Leu Val 
        675                 680                 685             


Pro Arg Gly Ser His His His His His His Ser Ala Trp Ser His Pro 
    690                 695                 700                 


Gln Phe Glu Lys 
705             


<210>  12
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Ser Leu Val Arg Gly Gln Ile Gly Asn Asp Pro Asn Arg 
            660                 665                 670         


Asp Ile Leu Gly Gly Leu Val Pro Arg Gly Ser His His His His His 
        675                 680                 685             


His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    690                 695                 


<210>  13
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Val Pro Arg Gly Ser His His His His His 
            660                 665                 670         


His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680             


<210>  14
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Val Pro Arg Gly Ser His His His His His 
            660                 665                 670         


His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680             


<210>  15
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15

Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu Thr 
1               5                   10                  15      


Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe Leu 
            20                  25                  30          


Leu Ala Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
        35                  40                  45              


Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly 
65                  70                  75                  80  


Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn 
                85                  90                  95      


Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala 
            100                 105                 110         


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val 
        115                 120                 125             


Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr 
    130                 135                 140                 


Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu Ile 
145                 150                 155                 160 


Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala 
                165                 170                 175     


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg 
            180                 185                 190         


Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp 
        195                 200                 205             


Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro 
                245                 250                 255     


Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile 
            260                 265                 270         


Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met 
        275                 280                 285             


Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys 
    290                 295                 300                 


Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala 
305                 310                 315                 320 


Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr 
                325                 330                 335     


Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly 
            340                 345                 350         


Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr 
        355                 360                 365             


Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser 
    370                 375                 380                 


Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe 
385                 390                 395                 400 


Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala 
                405                 410                 415     


Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly 
            420                 425                 430         


Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu 
        435                 440                 445             


Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu 
    450                 455                 460                 


Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser 
465                 470                 475                 480 


His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val 
                485                 490                 495     


Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys 
            500                 505                 510         


Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln 
        515                 520                 525             


Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
    530                 535                 540                 


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
545                 550                 555         


<210>  16
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu Thr 
1               5                   10                  15      


Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe Leu 
            20                  25                  30          


Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
        35                  40                  45              


Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Ser Ala Ser Lys Cys Glu Ser Ala Gly Thr His Ile Ala Gly 
65                  70                  75                  80  


Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn 
                85                  90                  95      


Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala 
            100                 105                 110         


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val 
        115                 120                 125             


Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr 
    130                 135                 140                 


Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu Ile 
145                 150                 155                 160 


Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala 
                165                 170                 175     


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg 
            180                 185                 190         


Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp 
        195                 200                 205             


Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro 
                245                 250                 255     


Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile 
            260                 265                 270         


Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met 
        275                 280                 285             


Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys 
    290                 295                 300                 


Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala 
305                 310                 315                 320 


Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr 
                325                 330                 335     


Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly 
            340                 345                 350         


Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr 
        355                 360                 365             


Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser 
    370                 375                 380                 


Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe 
385                 390                 395                 400 


Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala 
                405                 410                 415     


Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly 
            420                 425                 430         


Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu 
        435                 440                 445             


Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu 
    450                 455                 460                 


Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser 
465                 470                 475                 480 


His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val 
                485                 490                 495     


Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys 
            500                 505                 510         


Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln 
        515                 520                 525             


Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
    530                 535                 540                 


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
545                 550                 555         


<210>  17
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17

Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu Thr 
1               5                   10                  15      


Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe Leu 
            20                  25                  30          


Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
        35                  40                  45              


Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly 
65                  70                  75                  80  


Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn 
                85                  90                  95      


Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala 
            100                 105                 110         


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val 
        115                 120                 125             


Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr 
    130                 135                 140                 


Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu Ile 
145                 150                 155                 160 


Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala 
                165                 170                 175     


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg 
            180                 185                 190         


Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp 
        195                 200                 205             


Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Met Ser Gly Thr Ala Gln Ser Ala Ala His Ala 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro 
                245                 250                 255     


Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile 
            260                 265                 270         


Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met 
        275                 280                 285             


Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys 
    290                 295                 300                 


Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala 
305                 310                 315                 320 


Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr 
                325                 330                 335     


Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly 
            340                 345                 350         


Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr 
        355                 360                 365             


Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser 
    370                 375                 380                 


Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe 
385                 390                 395                 400 


Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala 
                405                 410                 415     


Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly 
            420                 425                 430         


Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu 
        435                 440                 445             


Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu 
    450                 455                 460                 


Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser 
465                 470                 475                 480 


His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val 
                485                 490                 495     


Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys 
            500                 505                 510         


Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln 
        515                 520                 525             


Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
    530                 535                 540                 


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
545                 550                 555         


<210>  18
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu Thr 
1               5                   10                  15      


Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe Leu 
            20                  25                  30          


Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
        35                  40                  45              


Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly 
65                  70                  75                  80  


Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn 
                85                  90                  95      


Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala 
            100                 105                 110         


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val 
        115                 120                 125             


Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr 
    130                 135                 140                 


Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu Ile 
145                 150                 155                 160 


Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala 
                165                 170                 175     


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg 
            180                 185                 190         


Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp 
        195                 200                 205             


Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Met Ser Gly Thr Thr Gln Ser Ala Ala His Ala 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro 
                245                 250                 255     


Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile 
            260                 265                 270         


Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met 
        275                 280                 285             


Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys 
    290                 295                 300                 


Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala 
305                 310                 315                 320 


Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr 
                325                 330                 335     


Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly 
            340                 345                 350         


Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr 
        355                 360                 365             


Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser 
    370                 375                 380                 


Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe 
385                 390                 395                 400 


Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala 
                405                 410                 415     


Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly 
            420                 425                 430         


Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu 
        435                 440                 445             


Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu 
    450                 455                 460                 


Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser 
465                 470                 475                 480 


His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val 
                485                 490                 495     


Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys 
            500                 505                 510         


Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln 
        515                 520                 525             


Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
    530                 535                 540                 


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
545                 550                 555         


<210>  19
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19

Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu Thr 
1               5                   10                  15      


Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe Leu 
            20                  25                  30          


Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
        35                  40                  45              


Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly 
65                  70                  75                  80  


Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn 
                85                  90                  95      


Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala 
            100                 105                 110         


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val 
        115                 120                 125             


Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr 
    130                 135                 140                 


Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu Ile 
145                 150                 155                 160 


Ala Ala Ala Gly Leu Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala 
                165                 170                 175     


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg 
            180                 185                 190         


Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp 
        195                 200                 205             


Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Met Ser Gly Thr Thr Gln Ser Ala Ala His Ala 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro 
                245                 250                 255     


Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile 
            260                 265                 270         


Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met 
        275                 280                 285             


Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys 
    290                 295                 300                 


Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala 
305                 310                 315                 320 


Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr 
                325                 330                 335     


Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly 
            340                 345                 350         


Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr 
        355                 360                 365             


Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser 
    370                 375                 380                 


Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe 
385                 390                 395                 400 


Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala 
                405                 410                 415     


Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly 
            420                 425                 430         


Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu 
        435                 440                 445             


Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu 
    450                 455                 460                 


Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser 
465                 470                 475                 480 


His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val 
                485                 490                 495     


Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys 
            500                 505                 510         


Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln 
        515                 520                 525             


Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
    530                 535                 540                 


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
545                 550                 555         


<210>  20
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Ala Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His 
            660                 665                 670         


His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685     


<210>  21
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser Ala Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His 
            660                 665                 670         


His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685     


<210>  22
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ala Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His 
            660                 665                 670         


His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685     


<210>  23
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Thr Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His 
            660                 665                 670         


His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685     


<210>  24
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Leu Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Thr Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His 
            660                 665                 670         


His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685     


<210>  25
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Gly 
            180                 185                 190         


Phe His Gly Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His 
            660                 665                 670         


His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685     


<210>  26
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Glu 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His 
            660                 665                 670         


His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685     


<210>  27
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Phe 
            180                 185                 190         


His Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly Val 
        195                 200                 205             


Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn Thr 
    210                 215                 220                 


Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala Leu 
225                 230                 235                 240 


Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val Ser 
                245                 250                 255     


Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr Leu 
            260                 265                 270         


Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu Ile Ala 
        275                 280                 285             


Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala Ser 
    290                 295                 300                 


Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg Pro 
305                 310                 315                 320 


Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp Val 
                325                 330                 335     


Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr 
            340                 345                 350         


Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His Ala Ala 
        355                 360                 365             


Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro Ala 
    370                 375                 380                 


Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile Asn 
385                 390                 395                 400 


Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met Val 
                405                 410                 415     


Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys Arg 
            420                 425                 430         


Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val 
        435                 440                 445             


Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser 
    450                 455                 460                 


Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln 
465                 470                 475                 480 


Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr Ala 
                485                 490                 495     


Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala 
            500                 505                 510         


Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln 
    530                 535                 540                 


Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu 
545                 550                 555                 560 


Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys 
                565                 570                 575     


His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu Val 
            580                 585                 590         


Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His 
        595                 600                 605             


Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile 
    610                 615                 620                 


Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys 
625                 630                 635                 640 


Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn 
                645                 650                 655     


Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His His 
            660                 665                 670         


His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 


<210>  28
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Ser 
            180                 185                 190         


Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly Val Leu Ser 
        195                 200                 205             


Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn Thr Val Arg 
    210                 215                 220                 


Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala Leu Ala Gly 
225                 230                 235                 240 


Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val Ser Pro Val 
                245                 250                 255     


Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr Leu Asn Thr 
            260                 265                 270         


Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu Ile Ala Ala Ala 
        275                 280                 285             


Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala Ser Glu Pro 
    290                 295                 300                 


Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg Pro Leu Ser 
305                 310                 315                 320 


Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp Val Phe Ala 
                325                 330                 335     


Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr Cys Phe 
            340                 345                 350         


Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His Ala Ala Gly Ile 
        355                 360                 365             


Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro Ala Glu Val 
    370                 375                 380                 


Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile Asn Pro Asp 
385                 390                 395                 400 


Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met Val Ala Ala 
                405                 410                 415     


Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys Arg Ser Val 
            420                 425                 430         


Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala Arg 
        435                 440                 445             


Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn 
    450                 455                 460                 


Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln Lys Val 
465                 470                 475                 480 


Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr Ala Val Ala 
                485                 490                 495     


Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser Leu 
            500                 505                 510         


His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr 
        515                 520                 525             


Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln Pro Ser 
    530                 535                 540                 


Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly 
545                 550                 555                 560 


Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys His Leu 
                565                 570                 575     


Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu Val Ser Cys 
            580                 585                 590         


Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His Gly Ser 
        595                 600                 605             


Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met 
    610                 615                 620                 


Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr 
625                 630                 635                 640 


Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn Thr Gly 
                645                 650                 655     


Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His His His His 
            660                 665                 670         


Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680         


<210>  29
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Gly 
            180                 185                 190         


Phe His Gly Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Gly Ser Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His 
            660                 665                 670         


His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685     


<210>  30
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Arg Ala Arg Arg Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
    130                 135                 140                 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Lys Lys Arg Lys 
145                 150                 155                 160 


Arg Arg Asp Gly Ala Gln Val Thr Val Phe Leu Leu Ala Thr Ser Val 
                165                 170                 175     


Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val Met Val Thr Asp Phe 
            180                 185                 190         


Asn Ser Met Pro Lys Glu Asp Gly Thr Arg Phe His Arg Ser Ala Ser 
        195                 200                 205             


Lys Cys Glu Ser His Gly Thr His Ile Ala Gly Val Leu Ser Gly Arg 
    210                 215                 220                 


Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn Thr Val Arg Val Leu 
225                 230                 235                 240 


Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala Leu Ala Gly Leu Glu 
                245                 250                 255     


Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val Ser Pro Val Ile Ile 
            260                 265                 270         


Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys 
        275                 280                 285             


Arg Glu Met Val His Ser Gly Ala Val Leu Ile Ala Ala Ala Gly Asn 
    290                 295                 300                 


Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala Ser Glu Pro Glu Val 
305                 310                 315                 320 


Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly 
                325                 330                 335     


Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp Val Phe Ala Pro Gly 
            340                 345                 350         


Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr Cys Phe Val Ser 
        355                 360                 365             


Met Ser Gly Thr Ser Gln Ser Ala Ala His Ala Ala Gly Ile Ala Ala 
    370                 375                 380                 


Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro Ala Glu Val Leu Gln 
385                 390                 395                 400 


Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile Asn Pro Asp Ser Leu 
                405                 410                 415     


Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met Val Ala Ala Leu Pro 
            420                 425                 430         


Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys Arg Ser Val Trp Ser 
        435                 440                 445             


Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala Arg Cys Arg 
    450                 455                 460                 


His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val 
465                 470                 475                 480 


His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln Lys Val Cys Glu 
                485                 490                 495     


Ala His His Gly Ile Gly Gly Gln Gly Val Tyr Ala Val Ala Arg Cys 
            500                 505                 510         


Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser Leu His Val 
        515                 520                 525             


Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys 
    530                 535                 540                 


Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln Pro Ser Trp Pro 
545                 550                 555                 560 


Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser 
                565                 570                 575     


His Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys His Leu Ile Glu 
            580                 585                 590         


His His Gln Ser Glu Phe Thr Lys Gln Val Glu Val Ser Cys Glu Asp 
        595                 600                 605             


Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His Gly Ser Val Thr 
    610                 615                 620                 


His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly 
625                 630                 635                 640 


Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro 
                645                 650                 655     


Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn Thr Gly Gly Leu 
            660                 665                 670         


Glu Val Leu Phe Gln Gly Pro Gly His His His His His His Ser Ala 
        675                 680                 685             


Trp Ser His Pro Gln Phe Glu Lys 
    690                 695     


<210>  31
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Arg Ala Arg Arg Pro Trp Asn Leu Gln Arg Ile Ile Gln 
    130                 135                 140                 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Lys Lys Arg Lys 
145                 150                 155                 160 


Arg Arg Asp Gly Ala Gln Val Thr Val Phe Leu Leu Ala Thr Ser Val 
                165                 170                 175     


Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val Met Val Thr Asp Phe 
            180                 185                 190         


Asn Ser Met Pro Lys Glu Asp Gly Thr Arg Phe His Arg Ser Ala Ser 
        195                 200                 205             


Lys Cys Glu Ser His Gly Thr His Ile Ala Gly Val Leu Ser Gly Arg 
    210                 215                 220                 


Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn Thr Val Arg Val Leu 
225                 230                 235                 240 


Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala Leu Ala Gly Leu Glu 
                245                 250                 255     


Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val Ser Pro Val Ile Ile 
            260                 265                 270         


Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys 
        275                 280                 285             


Arg Glu Met Val His Ser Gly Ala Val Leu Ile Ala Ala Ala Gly Asn 
    290                 295                 300                 


Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala Ser Glu Pro Glu Val 
305                 310                 315                 320 


Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly 
                325                 330                 335     


Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp Val Phe Ala Pro Gly 
            340                 345                 350         


Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr Cys Phe Val Ser 
        355                 360                 365             


Met Ser Gly Thr Ser Gln Ser Ala Ala His Ala Ala Gly Ile Ala Ala 
    370                 375                 380                 


Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro Ala Glu Val Leu Gln 
385                 390                 395                 400 


Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile Asn Pro Asp Ser Leu 
                405                 410                 415     


Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met Val Ala Ala Leu Pro 
            420                 425                 430         


Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys Arg Ser Val Trp Ser 
        435                 440                 445             


Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala Arg Cys Arg 
    450                 455                 460                 


His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val 
465                 470                 475                 480 


His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln Lys Val Cys Glu 
                485                 490                 495     


Ala His His Gly Ile Gly Gly Gln Gly Val Tyr Ala Val Ala Arg Cys 
            500                 505                 510         


Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser Leu His Val 
        515                 520                 525             


Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys 
    530                 535                 540                 


Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln Pro Ser Trp Pro 
545                 550                 555                 560 


Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser 
                565                 570                 575     


His Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys His Leu Ile Glu 
            580                 585                 590         


His His Gln Ser Glu Phe Thr Lys Gln Val Glu Val Ser Cys Glu Asp 
        595                 600                 605             


Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His Gly Ser Val Thr 
    610                 615                 620                 


His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly 
625                 630                 635                 640 


Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro 
                645                 650                 655     


Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn Thr Gly Gly Leu 
            660                 665                 670         


Glu Val Leu Phe Gln Gly Pro Gly His His His His His His Ser Ala 
        675                 680                 685             


Trp Ser His Pro Gln Phe Glu Lys 
    690                 695     


<210>  32
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Arg Ala Arg Arg Ser Ile Pro Trp Asn Leu Gln Arg Ile Tyr Thr 
    130                 135                 140                 


Pro Pro Asn Lys Lys Arg Lys Arg Arg Asp Gly Ala Gln Val Thr Val 
145                 150                 155                 160 


Phe Leu Leu Ala Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly 
                165                 170                 175     


Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr 
            180                 185                 190         


Arg Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile 
        195                 200                 205             


Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser 
    210                 215                 220                 


Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser 
225                 230                 235                 240 


Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln 
                245                 250                 255     


Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser 
            260                 265                 270         


Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val 
        275                 280                 285             


Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser 
    290                 295                 300                 


Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala 
305                 310                 315                 320 


Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys 
                325                 330                 335     


Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp 
            340                 345                 350         


Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala 
        355                 360                 365             


His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala 
    370                 375                 380                 


Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg 
385                 390                 395                 400 


Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro 
                405                 410                 415     


Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu 
            420                 425                 430         


Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp 
        435                 440                 445             


Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser 
    450                 455                 460                 


Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg 
465                 470                 475                 480 


Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly 
                485                 490                 495     


Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His 
            500                 505                 510         


Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln 
        515                 520                 525             


Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp 
    530                 535                 540                 


Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro 
545                 550                 555                 560 


Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn 
                565                 570                 575     


Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln 
            580                 585                 590         


Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala 
        595                 600                 605             


Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr 
    610                 615                 620                 


Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala 
625                 630                 635                 640 


Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His 
                645                 650                 655     


Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His 
            660                 665                 670         


His His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685         


<210>  33
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Arg Ala Arg Arg Pro Trp Asn Leu Gln Arg Ile Tyr Thr 
    130                 135                 140                 


Pro Pro Asn Lys Lys Arg Lys Arg Arg Asp Gly Ala Gln Val Thr Val 
145                 150                 155                 160 


Phe Leu Leu Ala Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly 
                165                 170                 175     


Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr 
            180                 185                 190         


Arg Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile 
        195                 200                 205             


Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser 
    210                 215                 220                 


Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser 
225                 230                 235                 240 


Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln 
                245                 250                 255     


Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser 
            260                 265                 270         


Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val 
        275                 280                 285             


Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser 
    290                 295                 300                 


Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala 
305                 310                 315                 320 


Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys 
                325                 330                 335     


Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp 
            340                 345                 350         


Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala 
        355                 360                 365             


His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala 
    370                 375                 380                 


Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg 
385                 390                 395                 400 


Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro 
                405                 410                 415     


Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu 
            420                 425                 430         


Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp 
        435                 440                 445             


Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser 
    450                 455                 460                 


Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg 
465                 470                 475                 480 


Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly 
                485                 490                 495     


Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His 
            500                 505                 510         


Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln 
        515                 520                 525             


Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp 
    530                 535                 540                 


Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro 
545                 550                 555                 560 


Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn 
                565                 570                 575     


Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln 
            580                 585                 590         


Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala 
        595                 600                 605             


Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr 
    610                 615                 620                 


Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala 
625                 630                 635                 640 


Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His 
                645                 650                 655     


Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His 
            660                 665                 670         


His His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685         


<210>  34
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Arg Ala Arg Arg Ser Ile Pro Trp Asn Leu Gln Arg Ile Gly Gly 
    130                 135                 140                 


Ser Gly Gly Tyr Thr Pro Pro Asn Lys Lys Arg Lys Arg Arg Asp Gly 
145                 150                 155                 160 


Ala Gln Val Thr Val Phe Leu Leu Ala Thr Ser Val Gln Thr Asp His 
                165                 170                 175     


Arg Glu Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro 
            180                 185                 190         


Lys Glu Asp Gly Thr Arg Phe His Arg Ser Ala Ser Lys Cys Glu Ser 
        195                 200                 205             


His Gly Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val 
    210                 215                 220                 


Ala Arg Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly 
225                 230                 235                 240 


Arg Gly Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala 
                245                 250                 255     


Ser Leu Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe 
            260                 265                 270         


Val Gly Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val 
        275                 280                 285             


His Ser Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp 
    290                 295                 300                 


Ala Cys Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly 
305                 310                 315                 320 


Ala Ser Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr 
                325                 330                 335     


Asn Leu Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile 
            340                 345                 350         


Ser Ala Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr 
        355                 360                 365             


Ser Gln Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn 
    370                 375                 380                 


Ala Tyr Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr 
385                 390                 395                 400 


His Ala Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His 
                405                 410                 415     


Tyr Leu Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala 
            420                 425                 430         


Thr Gly Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly 
        435                 440                 445             


Val Gly Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu 
    450                 455                 460                 


Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu 
465                 470                 475                 480 


Arg Ile Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly 
                485                 490                 495     


Ile Gly Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser 
            500                 505                 510         


Arg Val Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala 
        515                 520                 525             


Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr 
    530                 535                 540                 


Ile Arg Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn 
545                 550                 555                 560 


Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys 
                565                 570                 575     


Cys His Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser 
            580                 585                 590         


Glu Phe Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu 
        595                 600                 605             


Thr Gly Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr 
    610                 615                 620                 


Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly 
625                 630                 635                 640 


Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln 
                645                 650                 655     


Ser Asn Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe 
            660                 665                 670         


Gln Gly Pro Gly His His His His His His Ser Ala Trp Ser His Pro 
        675                 680                 685             


Gln Phe Glu Lys 
    690         


<210>  35
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Arg Ala Arg Arg Pro Trp Asn Leu Gln Arg Ile Gly Gly 
    130                 135                 140                 


Ser Gly Gly Tyr Thr Pro Pro Asn Lys Lys Arg Lys Arg Arg Asp Gly 
145                 150                 155                 160 


Ala Gln Val Thr Val Phe Leu Leu Ala Thr Ser Val Gln Thr Asp His 
                165                 170                 175     


Arg Glu Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro 
            180                 185                 190         


Lys Glu Asp Gly Thr Arg Phe His Arg Ser Ala Ser Lys Cys Glu Ser 
        195                 200                 205             


His Gly Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val 
    210                 215                 220                 


Ala Arg Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly 
225                 230                 235                 240 


Arg Gly Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala 
                245                 250                 255     


Ser Leu Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe 
            260                 265                 270         


Val Gly Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val 
        275                 280                 285             


His Ser Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp 
    290                 295                 300                 


Ala Cys Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly 
305                 310                 315                 320 


Ala Ser Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr 
                325                 330                 335     


Asn Leu Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile 
            340                 345                 350         


Ser Ala Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr 
        355                 360                 365             


Ser Gln Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn 
    370                 375                 380                 


Ala Tyr Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr 
385                 390                 395                 400 


His Ala Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His 
                405                 410                 415     


Tyr Leu Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala 
            420                 425                 430         


Thr Gly Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly 
        435                 440                 445             


Val Gly Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu 
    450                 455                 460                 


Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu 
465                 470                 475                 480 


Arg Ile Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly 
                485                 490                 495     


Ile Gly Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser 
            500                 505                 510         


Arg Val Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala 
        515                 520                 525             


Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr 
    530                 535                 540                 


Ile Arg Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn 
545                 550                 555                 560 


Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys 
                565                 570                 575     


Cys His Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser 
            580                 585                 590         


Glu Phe Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu 
        595                 600                 605             


Thr Gly Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr 
    610                 615                 620                 


Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly 
625                 630                 635                 640 


Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln 
                645                 650                 655     


Ser Asn Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe 
            660                 665                 670         


Gln Gly Pro Gly His His His His His His Ser Ala Trp Ser His Pro 
        675                 680                 685             


Gln Phe Glu Lys 
    690         


<210>  36
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Arg Ala Arg Arg Ser Ile Pro Trp Asn Leu Gln Arg Ile Gly Gly 
    130                 135                 140                 


Ser Gly Gly Tyr Thr Pro Pro Asn Lys Lys Arg Lys Arg Arg Gly Ser 
145                 150                 155                 160 


Gly Asp Gly Ala Gln Val Thr Val Phe Leu Leu Ala Thr Ser Val Gln 
                165                 170                 175     


Thr Asp His Arg Glu Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn 
            180                 185                 190         


Ser Met Pro Lys Glu Asp Gly Thr Arg Phe His Arg Ser Ala Ser Lys 
        195                 200                 205             


Cys Glu Ser His Gly Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp 
    210                 215                 220                 


Ala Gly Val Ala Arg Gly Val Ser Val Asn Thr Val Arg Val Leu Asn 
225                 230                 235                 240 


Cys Gln Gly Arg Gly Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr 
                245                 250                 255     


Ile Arg Ala Ser Leu Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu 
            260                 265                 270         


Leu Pro Phe Val Gly Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg 
        275                 280                 285             


Glu Met Val His Ser Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr 
    290                 295                 300                 


Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile 
305                 310                 315                 320 


Thr Val Gly Ala Ser Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr 
                325                 330                 335     


Thr Gly Thr Asn Leu Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu 
            340                 345                 350         


Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met 
        355                 360                 365             


Ser Gly Thr Ser Gln Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val 
    370                 375                 380                 


Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu 
385                 390                 395                 400 


Leu Arg Tyr His Ala Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro 
                405                 410                 415     


Pro Glu His Tyr Leu Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr 
            420                 425                 430         


Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys 
        435                 440                 445             


Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His 
    450                 455                 460                 


Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His 
465                 470                 475                 480 


Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala 
                485                 490                 495     


His His Gly Ile Gly Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys 
            500                 505                 510         


Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser Leu His Val Gly 
        515                 520                 525             


Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser 
    530                 535                 540                 


Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu 
545                 550                 555                 560 


His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His 
                565                 570                 575     


Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys His Leu Ile Glu His 
            580                 585                 590         


His Gln Ser Glu Phe Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser 
        595                 600                 605             


Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His Gly Ser Val Thr His 
    610                 615                 620                 


Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly 
625                 630                 635                 640 


Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu 
                645                 650                 655     


Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu 
            660                 665                 670         


Val Leu Phe Gln Gly Pro Gly His His His His His His Ser Ala Trp 
        675                 680                 685             


Ser His Pro Gln Phe Glu Lys 
    690                 695 


<210>  37
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Arg Ala Arg Arg Pro Trp Asn Leu Gln Arg Ile Gly Gly 
    130                 135                 140                 


Ser Gly Gly Tyr Thr Pro Pro Asn Lys Lys Arg Lys Arg Arg Gly Ser 
145                 150                 155                 160 


Gly Asp Gly Ala Gln Val Thr Val Phe Leu Leu Ala Thr Ser Val Gln 
                165                 170                 175     


Thr Asp His Arg Glu Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn 
            180                 185                 190         


Ser Met Pro Lys Glu Asp Gly Thr Arg Phe His Arg Ser Ala Ser Lys 
        195                 200                 205             


Cys Glu Ser His Gly Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp 
    210                 215                 220                 


Ala Gly Val Ala Arg Gly Val Ser Val Asn Thr Val Arg Val Leu Asn 
225                 230                 235                 240 


Cys Gln Gly Arg Gly Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr 
                245                 250                 255     


Ile Arg Ala Ser Leu Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu 
            260                 265                 270         


Leu Pro Phe Val Gly Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg 
        275                 280                 285             


Glu Met Val His Ser Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr 
    290                 295                 300                 


Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile 
305                 310                 315                 320 


Thr Val Gly Ala Ser Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr 
                325                 330                 335     


Thr Gly Thr Asn Leu Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu 
            340                 345                 350         


Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met 
        355                 360                 365             


Ser Gly Thr Ser Gln Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val 
    370                 375                 380                 


Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu 
385                 390                 395                 400 


Leu Arg Tyr His Ala Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro 
                405                 410                 415     


Pro Glu His Tyr Leu Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr 
            420                 425                 430         


Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys 
        435                 440                 445             


Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His 
    450                 455                 460                 


Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His 
465                 470                 475                 480 


Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala 
                485                 490                 495     


His His Gly Ile Gly Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys 
            500                 505                 510         


Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser Leu His Val Gly 
        515                 520                 525             


Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser 
    530                 535                 540                 


Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu 
545                 550                 555                 560 


His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His 
                565                 570                 575     


Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys His Leu Ile Glu His 
            580                 585                 590         


His Gln Ser Glu Phe Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser 
        595                 600                 605             


Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His Gly Ser Val Thr His 
    610                 615                 620                 


Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly 
625                 630                 635                 640 


Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu 
                645                 650                 655     


Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu 
            660                 665                 670         


Val Leu Phe Gln Gly Pro Gly His His His His His His Ser Ala Trp 
        675                 680                 685             


Ser His Pro Gln Phe Glu Lys 
    690                 695 


<210>  38
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Ile Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Gln Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  39
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Ile Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Gln Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Ile Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  40
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Ile Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Leu Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  41
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Ile Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Leu Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Ile Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  42
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Gln Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  43
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Gln Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Ile Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  44
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Leu Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  45
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Leu Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Ile Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  46
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Gln 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Ile Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Gln Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  47
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Gln 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Ile Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Gln Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Ile Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  48
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Gln 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Ile Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Leu Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  49
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Gln 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Ile Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Leu Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Ile Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  50
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Gln 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Gln Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  51
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Gln 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Gln Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Ile Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  52
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Gln 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Leu Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  53
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Gln 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Leu Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Gln Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Ile Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  54
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  55
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Gln 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  56
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Ile Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  57
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  58
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Gln Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  59
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Leu Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  60
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  61
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  61

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Ile Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  62
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  63
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  63

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Lys Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  64
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  64

Met Ile Ala Ser Lys Lys Thr Thr Asp Phe Trp Lys Met Ser Phe Phe 
1               5                   10                  15      


Leu Val Met Cys Leu Ala Ala Leu Ala Ala Cys Asp Asn Pro Glu Glu 
            20                  25                  30          


Lys Pro Val Asn Ala Pro Val Ile Val His Pro Pro Pro Pro Arg Thr 
        35                  40                  45              


Glu Arg Val Ala Glu Phe Leu Arg Cys Thr Lys Ser Ala Trp Cys Ile 
    50                  55                  60                  


Pro Asp Gln Tyr Leu Val Val Leu Gln Glu Gly Ala His Asp Ser His 
65                  70                  75                  80  


Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala Arg Ser Arg 
                85                  90                  95      


His Thr Ile His Ile Thr His Thr Tyr Ser Gly Ala Phe Cys Gly Phe 
            100                 105                 110         


Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu Lys Leu Pro 
        115                 120                 125             


His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln Ser Ile 
    130                 135                 140                 


Pro Trp Asn Leu Gln Arg Ile Met Gln Thr Lys His Glu Thr Gly Lys 
145                 150                 155                 160 


Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe Leu Leu Asp 
                165                 170                 175     


Thr Ser Ile Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val Met Val 
            180                 185                 190         


Thr Asp Phe Asn Ser Val Pro Lys Glu Asp Gly Thr Arg Phe His Arg 
        195                 200                 205             


Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly Val Leu 
    210                 215                 220                 


Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Gly Val Asn Thr Val 
225                 230                 235                 240 


Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala Leu Ala 
                245                 250                 255     


Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val Arg Pro 
            260                 265                 270         


Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr Leu Asn 
        275                 280                 285             


Ile Ala Cys Gln Glu Met Val His Ser Gly Ala Val Leu Ile Ala Ala 
    290                 295                 300                 


Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala Ser Glu 
305                 310                 315                 320 


Pro Glu Val Ile Thr Ile Gly Ala Thr Asn Ala Ala Asp Gln Leu Leu 
                325                 330                 335     


Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp Val Phe 
            340                 345                 350         


Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr Cys 
        355                 360                 365             


Phe Val Ser Lys Arg Gly Thr Ser Gln Ser Ala Ala His Ala Ala Gly 
    370                 375                 380                 


Ile Ala Ala Val Leu Leu Asn Ala His Pro Ser Ala Ser Pro Ala Glu 
385                 390                 395                 400 


Val Leu Gln Leu Leu Arg Tyr His Ser Val Gln His Val Ile Asn Pro 
                405                 410                 415     


Asp Ser Leu Pro Pro Glu His Tyr His Thr Thr Pro Asp Met Val Ala 
            420                 425                 430         


Ala Leu Pro Lys Ser Ala Ala Thr Gly Glu Thr Leu Leu Cys Arg Ser 
        435                 440                 445             


Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala 
    450                 455                 460                 


His Cys Arg Arg Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro 
465                 470                 475                 480 


Asn Gly Val His Ala Gly Glu Lys Ile Glu Ile Arg Asp Gly Gln Lys 
                485                 490                 495     


Val Cys Glu Ser His His Ala Ile Gly Gly His Gly Val Tyr Ala Val 
            500                 505                 510         


Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser 
        515                 520                 525             


Leu His Val Gly Val Asp Ala Glu Cys Pro Ser Gln Glu Tyr Gln Leu 
    530                 535                 540                 


Thr Gly Cys Ser Ser His Tyr Ile Arg Ser His Asp Thr Ala Gln Pro 
545                 550                 555                 560 


Ser Arg Leu Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly 
                565                 570                 575     


Gly Thr Ser His Ala Ser Cys Cys Arg Ala Pro Asn Leu Glu Cys His 
            580                 585                 590         


Leu Ile Glu Phe Thr Arg Gln Val Glu Val Ser Cys Glu Asp Ser Trp 
        595                 600                 605             


Thr Leu Thr Trp Cys Ile Ala Ala Ser His Gly Ser Val Thr His Gly 
    610                 615                 620                 


Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Glu His 
625                 630                 635                 640 


Lys Gly Thr Ala Ala Leu Ala Ile Cys Cys Arg Phe Arg Pro Leu Asp 
                645                 650                 655     


Gln Gln Ser Asn Lys Asn His Glu Gln Asn Thr 
            660                 665         


<210>  65
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  65

Met Ile Ala Ser Lys Lys Thr Thr Asp Phe Trp Lys Met Ser Phe Phe 
1               5                   10                  15      


Leu Val Met Cys Leu Ala Ala Leu Ala Ala Cys Asp Asn Pro Glu Glu 
            20                  25                  30          


Lys Pro Val Asn Ala Pro Val Ile Val His Pro Pro Pro Pro Arg Thr 
        35                  40                  45              


Glu Arg Val Ala Glu Phe Leu Arg Cys Thr Lys Ser Ala Trp Cys Ile 
    50                  55                  60                  


Pro Asp Gln Tyr Leu Val Val Leu Gln Glu Gly Ala His Asp Ser His 
65                  70                  75                  80  


Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala Arg Ser Arg 
                85                  90                  95      


His Thr Ile His Ile Thr His Thr Tyr Ser Gly Ala Phe Cys Gly Phe 
            100                 105                 110         


Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu Lys Leu Pro 
        115                 120                 125             


His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln Ser Ile 
    130                 135                 140                 


Pro Trp Asn Leu Gln Arg Ile Met Gln Thr Lys His Glu Thr Gly Lys 
145                 150                 155                 160 


Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe Leu Leu Asp 
                165                 170                 175     


Thr Ser Ile Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val Met Val 
            180                 185                 190         


Thr Asp Phe Asn Ser Val Pro Lys Glu Asp Gly Thr Arg Phe His Gln 
        195                 200                 205             


Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly Val Leu 
    210                 215                 220                 


Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Gly Val Asn Thr Val 
225                 230                 235                 240 


Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala Leu Ala 
                245                 250                 255     


Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val Arg Pro 
            260                 265                 270         


Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr Leu Asn 
        275                 280                 285             


Ile Ala Cys Gln Glu Met Val His Ser Gly Ala Val Leu Ile Ala Ala 
    290                 295                 300                 


Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala Ser Glu 
305                 310                 315                 320 


Pro Glu Val Ile Thr Ile Gly Ala Thr Asn Ala Ala Asp Gln Leu Leu 
                325                 330                 335     


Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp Val Phe 
            340                 345                 350         


Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr Cys 
        355                 360                 365             


Phe Thr Ser Lys Arg Gly Thr Ser Gln Ser Ala Ala His Ala Ala Gly 
    370                 375                 380                 


Ile Ala Ala Val Leu Leu Asn Ala His Pro Ser Ala Ser Pro Ala Glu 
385                 390                 395                 400 


Val Leu Gln Leu Leu Arg Tyr His Ser Val Gln His Val Ile Asn Pro 
                405                 410                 415     


Asp Ser Leu Pro Pro Glu His Tyr His Thr Thr Pro Asp Met Val Ala 
            420                 425                 430         


Ala Leu Pro Lys Ser Ala Ala Thr Gly Glu Thr Leu Leu Cys Arg Ser 
        435                 440                 445             


Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala 
    450                 455                 460                 


His Cys Arg Arg Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro 
465                 470                 475                 480 


Asn Gly Val His Ala Gly Glu Lys Ile Glu Ile Arg Asp Gly Gln Lys 
                485                 490                 495     


Val Cys Glu Ser His His Ala Ile Gly Gly His Gly Val Tyr Ala Val 
            500                 505                 510         


Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser 
        515                 520                 525             


Leu His Val Gly Val Asp Ala Glu Cys Pro Ser Gln Glu Tyr Gln Leu 
    530                 535                 540                 


Thr Gly Cys Ser Ser His Tyr Ile Arg Ser His Asp Thr Ala Gln Pro 
545                 550                 555                 560 


Ser Arg Leu Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly 
                565                 570                 575     


Gly Thr Ser His Ala Ser Cys Cys Arg Ala Pro Asn Leu Glu Cys His 
            580                 585                 590         


Leu Ile Glu Phe Thr Arg Gln Val Glu Val Ser Cys Glu Asp Ser Trp 
        595                 600                 605             


Thr Leu Thr Trp Cys Ile Ala Ala Ser His Gly Ser Val Thr His Gly 
    610                 615                 620                 


Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Glu His 
625                 630                 635                 640 


Lys Gly Thr Ala Ala Leu Ala Ile Cys Cys Arg Phe Arg Pro Leu Asp 
                645                 650                 655     


Gln Gln Ser Asn Lys Asn His Glu Gln Asn Thr 
            660                 665         


<210>  66
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  66

Met Arg Arg Thr Ser Ala Trp Val Gly Trp Val Leu Cys Leu Cys Thr 
1               5                   10                  15      


Ser Leu Ala Ala Ser Ala Gln Asp Tyr Pro Asp Gly Asp Glu Met Ile 
            20                  25                  30          


Leu Asp Met Phe Ser Glu Asp Gly Thr Lys Pro Glu Pro Arg Ala Val 
        35                  40                  45              


Pro Thr Ala Glu Phe Leu Lys Cys Asn Lys Ala Ala Trp Arg Val His 
    50                  55                  60                  


Gly Gln Tyr Leu Val Val Leu Arg Gln Gly Thr His Gly Ser His Val 
65                  70                  75                  80  


Gln Arg Thr Ile Arg Arg Leu Arg Ala Lys Ala Ala Arg Arg Gly Gln 
                85                  90                  95      


Leu Leu Glu Ile Leu His Thr Tyr Ser Ala Ala Leu His Gly Phe Met 
            100                 105                 110         


Val Lys Met Ser Ser Asp Val Leu His Leu Ala Leu Lys Leu Pro Gln 
        115                 120                 125             


Val His Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln Ser Ile Pro 
    130                 135                 140                 


Trp Asn Leu Gln Arg Leu Leu Gln Pro His Gly Gly Ser Ser Glu Ser 
145                 150                 155                 160 


Gly Thr Tyr Arg Pro Pro Asn Asp Gly Gly Met Ala Leu Val Tyr Leu 
                165                 170                 175     


Leu Asp Gly Ser Val Gln Ser Asp His Arg Glu Val Glu Gly Arg Val 
            180                 185                 190         


Leu Ile Thr Asp Phe Asn Ser Val Pro Lys Glu Asp Gly Thr Arg Phe 
        195                 200                 205             


His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly 
    210                 215                 220                 


Val Val Thr Gly Arg Asp Ala Gly Val Ala Arg Gly Ala Gly Val Asn 
225                 230                 235                 240 


Leu Val Arg Ile Leu Asn Cys Gln Gly Lys Gly Ser Val Ser Gly Ala 
                245                 250                 255     


Leu Ala Gly Leu Glu Tyr Ile Gln Ser Thr Leu Leu Ala Arg Pro Val 
            260                 265                 270         


Asp Ala Val Val Val Leu Leu Pro Phe Ser Gly Gly Phe Ser Arg Ser 
        275                 280                 285             


Leu Asn Ala Ala Cys Arg Asp Met Val Ala Lys Gly Ala Val Val Ile 
    290                 295                 300                 


Ala Ala Ala Gly Asn Tyr Arg Asp Asp Ala Cys Phe Tyr Ser Pro Ala 
305                 310                 315                 320 


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Val Asn Ser Val Asp Gln 
                325                 330                 335     


Leu Met Ser Gln Gly Ala Gly Gly Thr Asn Phe Gly Arg Cys Ile Asp 
            340                 345                 350         


Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
        355                 360                 365             


Thr Cys Phe Thr Ser Arg Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
    370                 375                 380                 


Ala Gly Ile Ala Ala Val Ile Leu Ser Ser Asn Gln Gln Val Ser Pro 
385                 390                 395                 400 


Val Gln Val Met Gln Met Met Leu His Tyr Ser Ser Ser His Thr Ile 
                405                 410                 415     


Asn Phe Leu Ser Leu Pro Asp Ser His Arg Leu Ile Ser Pro Asn Leu 
            420                 425                 430         


Val Ala Ala Met Pro Pro Ala Asn Ser Ala Lys Glu Leu Leu Cys Arg 
        435                 440                 445             


Ser Val Trp Ser Lys Arg Ser Gly Val Thr Ser Ser Asp Gln Ala Val 
    450                 455                 460                 


Ser Arg Cys Arg Leu Gly Glu Glu Met Met Ser Cys Ser Ser Tyr Thr 
465                 470                 475                 480 


Leu Asp Gly Val His Ala Gly Glu Thr Ile Ser Glu Ser Ser Gly Gln 
                485                 490                 495     


Met Glu Cys Val Ala Phe Asn Ala Leu Gly Gly Glu Gly Val Tyr Ala 
            500                 505                 510         


Val Ala Arg Cys Cys Val Ile Gly Gly Leu Gln Cys Gln Val His Ala 
        515                 520                 525             


Ser Pro Glu Cys Val Ala Thr Gln His His Leu Thr Gly Cys Thr Leu 
    530                 535                 540                 


Arg Ser Ala Ala Gly Ile Ser Ala Asp Ser Arg Pro His Gly Ser Asp 
545                 550                 555                 560 


Arg Arg Arg Cys Val Gly Ser Ser Gly Ala Thr Ser His Ala Val Cys 
                565                 570                 575     


Cys His Ala Pro Ser Leu Glu Cys Arg Leu Met Glu Lys Ile Ser Ala 
            580                 585                 590         


Asp Lys Asp Gln Val Glu Leu Ser Cys Pro Ser Gly Trp Thr Leu Thr 
        595                 600                 605             


Asp Cys Ser Ala Val Ser Pro Gly Ser Val Ile Leu Ala Pro Val Ala 
    610                 615                 620                 


Lys Gly Asn Ser Cys His Val Gly Ser Ala Ser Gly Ala Gly Gly Ala 
625                 630                 635                 640 


Ala Gly Val Val Val Cys Cys Arg Val Arg Gln Pro Glu Gln Arg Arg 
                645                 650                 655     


Ala Ser Pro 
            


<210>  67
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  67

Met Arg Arg Thr Ser Ala Trp Val Gly Trp Ala Leu Cys Leu Cys Ala 
1               5                   10                  15      


Ser Leu Ala Ala Asn Ala Gln Asp Tyr Pro Glu Asp Asp Glu Met Ile 
            20                  25                  30          


Leu Asp Leu Ile Arg Glu Asp Gly Thr Gln Pro Glu Thr Gly Thr Glu 
        35                  40                  45              


Pro Ala Ala Glu Phe Leu Arg Cys Asn Lys Ala Ala Trp Arg Met Pro 
    50                  55                  60                  


Gly Lys Tyr Leu Val Ile Leu Arg Gln Gly Thr His Gly Ser His Val 
65                  70                  75                  80  


Gln Arg Thr Ile Arg Arg Leu Arg Ala Lys Ala Ala Arg Arg Ser Tyr 
                85                  90                  95      


Leu Leu Glu Ile Leu Gln Thr Tyr Ser Gly Ala Leu Lys Gly Phe Leu 
            100                 105                 110         


Val Lys Met Ser Ser Asp Val Leu His Leu Ala Val Lys Leu Pro His 
        115                 120                 125             


Val His Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln Ser Ile Pro 
    130                 135                 140                 


Trp Asn Leu Gln Arg Leu Leu Gln Pro Arg Gly Gly Thr Ser Glu Ser 
145                 150                 155                 160 


Gly Thr Tyr Gln Pro Pro Asn Asp Gly Ala Met Ala Glu Val Tyr Leu 
                165                 170                 175     


Met Asp Gly Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
            180                 185                 190         


Leu Ile Thr Asp Phe Asn Asp Val Pro Lys Glu Asp Gly Thr Arg Phe 
        195                 200                 205             


His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Met Ala Gly 
    210                 215                 220                 


Val Val Thr Gly Arg Asp Ala Gly Val Ala Arg Gly Ala Asp Val Asn 
225                 230                 235                 240 


Leu Val Arg Ile Leu Asn Cys Gln Gly Lys Gly Ser Val Ser Gly Ala 
                245                 250                 255     


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Thr Leu Leu Ala Arg Pro Val 
            260                 265                 270         


Glu Ala Val Val Val Leu Leu Pro Phe Ile Gly Gly Phe Ser Arg Ser 
        275                 280                 285             


Leu Asn Thr Ala Cys Arg Asp Met Val Ala Asn Gly Ala Val Val Ile 
    290                 295                 300                 


Ala Ala Ala Gly Asn Tyr Arg Asp Asp Ala Cys Met Tyr Ser Pro Ala 
305                 310                 315                 320 


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Val Asn Ser Ala Asp Gln 
                325                 330                 335     


Leu Met Ser Gln Gly Ala Gly Gly Thr Asn Val Gly Arg Cys Val Asp 
            340                 345                 350         


Phe Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
        355                 360                 365             


Thr Cys Phe Thr Ser Arg Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
    370                 375                 380                 


Ala Gly Ile Ala Ala Val Ile Leu Ser Ser Ser Gln Gln Met Ser Pro 
385                 390                 395                 400 


Val His Val Leu Gln Thr Met Leu His His Ser Ile Ser Asn Thr Ile 
                405                 410                 415     


Asn Leu Leu Ser Leu Ser Glu Thr His Tyr Leu Thr Thr Pro Asn Leu 
            420                 425                 430         


Val Ala Ala Met Pro Pro Thr Gln Arg Thr Asn Ala Asp Gly Glu Leu 
        435                 440                 445             


Leu Cys Arg Ser Val Trp Ser Glu Lys Ser Gly Val Ala Ser Ala Asp 
    450                 455                 460                 


Arg Ala Val Ser Arg Cys Arg Leu Gly Glu Glu Met Leu Gly Cys Ser 
465                 470                 475                 480 


Ser Tyr Thr Pro Asp Gly Val Arg Val Gly Glu Ser Ile Ala Ile Asn 
                485                 490                 495     


Gly Glu Arg Met Glu Cys Val Ala Tyr Asn Gly Pro Gly Gly Lys Gly 
            500                 505                 510         


Val Tyr Ala Val Ala Arg Cys Cys Ala Ile Gly Gly Leu Arg Cys Gln 
        515                 520                 525             


Val His Ala Ser Pro Lys Pro Gly Gln Asp Ala Glu Cys Ile Asp Pro 
    530                 535                 540                 


Gln His His Leu Thr Gly Cys Thr Ser Trp Ser Thr Thr Lys Thr Leu 
545                 550                 555                 560 


Ser Asp Ser Arg Pro His His Gly Asp Arg Arg Arg Cys Ile Val Lys 
                565                 570                 575     


Asn Gly Val Ala Ser His Ala Val Cys Cys His Ala Pro Ala Leu Gln 
            580                 585                 590         


Cys Leu Leu Met Glu 
        595         


<210>  68
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  68

Met Arg Arg Thr Ser Ala Trp Val Gly Trp Ala Leu Cys Leu Cys Ala 
1               5                   10                  15      


Ser Leu Ala Ala Asn Ala Gln Asp Tyr Pro Glu Asp Asp Glu Met Ile 
            20                  25                  30          


Leu Asp Leu Ile Arg Glu Asp Gly Thr Gln Pro Glu Thr Gly Thr Glu 
        35                  40                  45              


Pro Ala Ala Glu Phe Leu Arg Cys Asn Lys Ala Ala Trp Arg Met Pro 
    50                  55                  60                  


Gly Lys Tyr Leu Val Ile Leu Arg Gln Gly Thr His Gly Ser His Val 
65                  70                  75                  80  


Gln Arg Thr Ile Arg Arg Leu Arg Ala Lys Ala Ala Arg Arg Ser Tyr 
                85                  90                  95      


Leu Leu Glu Ile Leu Gln Thr Tyr Ser Gly Ala Leu Lys Gly Phe Leu 
            100                 105                 110         


Val Lys Met Ser Ser Asp Val Leu His Leu Ala Val Lys Leu Pro His 
        115                 120                 125             


Val His Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln Ser Ile Pro 
    130                 135                 140                 


Trp Asn Leu Gln Arg Leu Leu Gln Pro Arg Gly Gly Thr Ser Glu Ser 
145                 150                 155                 160 


Gly Thr Tyr Gln Pro Pro Asn Asp Gly Ala Met Ala Glu Val Tyr Leu 
                165                 170                 175     


Met Asp Gly Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
            180                 185                 190         


Leu Ile Thr Asp Phe Asn Asp Val Pro Lys Glu Asp Gly Thr Arg Phe 
        195                 200                 205             


His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Met Ala Gly 
    210                 215                 220                 


Val Val Thr Gly Arg Asp Ala Gly Val Ala Arg Gly Ala Asp Val Asn 
225                 230                 235                 240 


Leu Val Arg Ile Leu Asn Cys Gln Gly Lys Gly Ser Val Ser Gly Ala 
                245                 250                 255     


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Thr Leu Leu Ala Arg Pro Val 
            260                 265                 270         


Glu Ala Val Val Val Leu Leu Pro Phe Ile Gly Gly Phe Ser Arg Ser 
        275                 280                 285             


Leu Asn Thr Ala Cys Arg Asp Met Val Ala Asn Gly Ala Val Val Ile 
    290                 295                 300                 


Ala Ala Ala Gly Asn Tyr Arg Asp Asp Ala Cys Met Tyr Ser Pro Ala 
305                 310                 315                 320 


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Val Asn Ser Ala Asp Gln 
                325                 330                 335     


Leu Met Ser Gln Gly Ala Gly Gly Thr Asn Val Gly Arg Cys Val Asp 
            340                 345                 350         


Phe Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
        355                 360                 365             


Thr Cys Phe Thr Ser Arg Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
    370                 375                 380                 


Ala Gly Ile Ala Ala Val Ile Leu Ser Ser Ser Gln Gln Met Ser Pro 
385                 390                 395                 400 


Val His Val Leu Gln Thr Met Leu His His Ser Ile Ser Asn Thr Ile 
                405                 410                 415     


Asn Leu Leu Ser Leu Ser Glu Thr His Tyr Leu Thr Thr Pro Asn Leu 
            420                 425                 430         


Val Ala Ala Met Pro Pro Thr Gln Arg Thr Asn Ala Asp Gly Glu Leu 
        435                 440                 445             


Leu Cys Arg Ser Val Trp Ser Glu Lys Ser Gly Val Ala Ser Ala Asp 
    450                 455                 460                 


Arg Ala Val Ser Arg Cys Arg Leu Gly Glu Glu Met Leu Gly Cys Ser 
465                 470                 475                 480 


Ser Tyr Thr Pro Asp Gly Val Arg Val Gly Glu Ser Ile Ala Ile Asn 
                485                 490                 495     


Gly Glu Arg Met Glu Cys Val Ala Tyr Asn Gly Pro Gly Gly Lys Gly 
            500                 505                 510         


Val Tyr Ala Val Ala Arg Cys Cys Ala Ile Gly Gly Leu Arg Cys Gln 
        515                 520                 525             


Val His Ala Ser Pro Lys Pro Gly Gln Asp Ala Glu Cys Ile Asp Pro 
    530                 535                 540                 


Gln His His Leu Thr Gly Cys Thr Ser Trp Ser Thr Thr Lys Thr Leu 
545                 550                 555                 560 


Ser Asp Ser Arg Pro His His Gly Asp Arg Arg Arg Cys Ile Val Lys 
                565                 570                 575     


Asn Gly Val Ala Ser His Ala Val Cys Cys His Ala Pro Ala Leu Gln 
            580                 585                 590         


Cys Leu Leu Met Glu 
        595         


<210>  69
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  69

Met Leu Lys Lys Val Leu Ser Cys Cys Ile Ala Ala Thr Phe Gly Ile 
1               5                   10                  15      


Tyr Ser Ala Ser Ser Leu Ala Gln Ser Ser Ile Pro Trp Gly Leu Asp 
            20                  25                  30          


Arg Ile Asp Gln Arg Asn Leu Pro Leu Asp Arg Asn Tyr Asn Ala Asn 
        35                  40                  45              


Phe Asp Gly Phe Gly Val Thr Ala Tyr Val Ile Asp Thr Gly Val Asn 
    50                  55                  60                  


Asn Asp His Arg Glu Ile Glu Gly Arg Ser Val Ser Gly Tyr Asp Gly 
65                  70                  75                  80  


Thr Arg Phe His Ala Asp Ala Ser Lys Cys Glu Ser His Gly Thr His 
                85                  90                  95      


Val Ala Gly Thr Ile Gly Gly Arg Asp Ser Gly Val Ala Lys Asn Val 
            100                 105                 110         


Asn Ile Val Gly Val Arg Val Leu Ser Cys Ser Gly Ser Gly Thr Thr 
        115                 120                 125             


Ser Gly Val Ile Ser Gly Val Asp Trp Val Ala Gln Gln Ala Ser Gly 
    130                 135                 140                 


Pro Ser Val Ala Ser Met Ser Leu Gly Gly Gly Gln Ser Thr Ala Leu 
145                 150                 155                 160 


Asp Ser Ala Val Gln Gly Ala Ile Gln Ser Gly Val Ser Phe Met Leu 
                165                 170                 175     


Ala Ala Gly Asn Ser Asn Ala Asp Ala Cys Gln Thr Ser Pro Ala Arg 
            180                 185                 190         


Val Pro Ser Gly Val Thr Val Gly Ser Thr Thr Ser Ser Asp Ser Arg 
        195                 200                 205             


Ser Ser Phe Ser Asn Trp Gly Ser Cys Val Asp Val Phe Ala Pro Gly 
    210                 215                 220                 


Glu Asp Ile Ile Ser Ala Ser Tyr Asp Cys Ser Thr Cys Phe Thr Ser 
225                 230                 235                 240 


Ile Ser Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Val Ala Ala 
                245                 250                 255     


Leu Tyr Leu Gln Glu Asn Asn Gly Leu Thr Pro Leu Gln Leu Thr Gly 
            260                 265                 270         


Leu Leu Asn Ser Arg Ala Ser Glu Asn Lys Val Ser Asp Thr Arg Gly 
        275                 280                 285             


Thr Thr Asn Lys Leu Leu Tyr Ser Leu Ala Asp Ser Gly Cys Glu Pro 
    290                 295                 300                 


Asp Cys Gly Gly Pro 
305                 


<210>  70
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  70

Met Leu Lys Lys Val Leu Ser Cys Cys Ile Ala Ala Thr Phe Gly Ile 
1               5                   10                  15      


Tyr Ser Ala Ser Ser Leu Ala Ala Thr Gln Thr Ser Ile Pro Trp Gly 
            20                  25                  30          


Leu Asp Arg Ile Asp Gln Arg Thr Leu Pro Leu Ser Gly Thr Phe Thr 
        35                  40                  45              


Tyr Ser Asn Thr Gly Ser Gly Val Asn Ala Tyr Ile Ile Asp Thr Gly 
    50                  55                  60                  


Ile Arg Val Asp His Arg Glu Ile Glu Gly Arg Ala Thr Ala Val Phe 
65                  70                  75                  80  


Asp Gly Thr Arg Phe His Gln Gln Ala Ser Lys Cys Glu Ser His Gly 
                85                  90                  95      


Thr His Val Ala Gly Thr Val Gly Gly Arg Asp Ser Gly Val Ala Lys 
            100                 105                 110         


Ser Val Arg Leu Tyr Ala Val Arg Val Leu Ser Cys Ser Gly Ser Gly 
        115                 120                 125             


Ser Asn Ser Gly Val Ile Ala Gly Val Asp Trp Val Arg Gln Asn Ala 
    130                 135                 140                 


Arg Arg Pro Ala Val Ala Ser Met Ser Leu Gly Gly Gly Ala Ser Ser 
145                 150                 155                 160 


Ala Leu Asp Thr Ala Val Asn Asn Ala Ile Asn Ala Gly Ile Thr Phe 
                165                 170                 175     


Ala Leu Ala Ala Gly Asn Ser Asn Arg Asp Ala Cys Gln Phe Ser Pro 
            180                 185                 190         


Ala Arg Val Thr Ala Gly Ile Thr Val Gly Ala Thr Thr Ser Thr Asp 
        195                 200                 205             


Ala Arg Ala Ser Tyr Ser Asn Tyr Gly Ser Cys Leu Asp Val Phe Ala 
    210                 215                 220                 


Pro Gly Glu Asp Ile Ile Ser Ala Ser Ile Asp Cys Ser Thr Cys Phe 
225                 230                 235                 240 


Thr Ser Ile Ser Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Val 
                245                 250                 255     


Ala Ala Leu Tyr Leu Gln Ser Asn Pro Ser Ala Ser Pro Ala Thr Val 
            260                 265                 270         


Arg Asn Ala Ile Val Gly Gln Ala Thr Ser Gly Val Val Ser Asn Ala 
        275                 280                 285             


Gly Arg Arg Ser Pro Asn Leu Leu Leu Tyr Ser Asn Tyr Glu Asn Leu 
    290                 295                 300                 


Tyr 
305 


<210>  71
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  71

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  72
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  72

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Gln 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Ile Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Ile Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  73
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  73

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Ala Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  74
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  74

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Gly Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  75
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  75

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Leu Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  76
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  76

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Glu Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  77
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  77

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Ala Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  78
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  78

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Ser Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  79
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  79

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Asp Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  80
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  80

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Val Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  81
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  81

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Asp Asp Ile Val Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  82
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  82

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Asn Asp Ile Val Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  83
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  83

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Asp Asn Ile Val Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  84
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  84

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Ile Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  85
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  85

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Ile Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Val Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Val Pro Arg Gly Ser His His His His His 
            660                 665                 670         


His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680             


<210>  86
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  87
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  87

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Val Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Ala Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His 
            660                 665                 670         


His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685     


<210>  88
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  88

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Leu Asp Asn Thr Thr Gly Val Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His 
            660                 665                 670         


His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685     


<210>  89
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  89

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Leu Asp Asn Thr Thr Gly Val Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Pro Ala Lys Tyr Asp Ser Val Ile Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His 
            660                 665                 670         


His His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685     


<210>  90
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  90

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Thr Val Phe Thr Ser Trp Glu Glu Tyr Leu Asp Trp Val 
    130                 135                 140                 


Gly Ser Gly Ile Pro Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr 
145                 150                 155                 160 


Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val 
                165                 170                 175     


Thr Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile 
            180                 185                 190         


Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp 
        195                 200                 205             


Gly Thr Arg Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr 
    210                 215                 220                 


His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly 
225                 230                 235                 240 


Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr 
                245                 250                 255     


Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln 
            260                 265                 270         


Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly 
        275                 280                 285             


Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly 
    290                 295                 300                 


Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met 
305                 310                 315                 320 


Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn 
                325                 330                 335     


Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly 
            340                 345                 350         


Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser 
        355                 360                 365             


Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser 
    370                 375                 380                 


Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro 
385                 390                 395                 400 


Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val 
                405                 410                 415     


Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr 
            420                 425                 430         


Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu 
        435                 440                 445             


Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser 
    450                 455                 460                 


Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser 
465                 470                 475                 480 


Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu 
                485                 490                 495     


Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly 
            500                 505                 510         


Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys 
        515                 520                 525             


Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro 
    530                 535                 540                 


Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser 
545                 550                 555                 560 


Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala 
                565                 570                 575     


Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala 
            580                 585                 590         


Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr 
        595                 600                 605             


Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys 
    610                 615                 620                 


Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly 
625                 630                 635                 640 


Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala 
                645                 650                 655     


Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn 
            660                 665                 670         


Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro 
        675                 680                 685             


Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe Glu 
    690                 695                 700                 


Lys 
705 


<210>  91
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  91

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Thr Val Phe Thr Ser Trp Glu Glu Tyr Leu Asp Trp Val 
    130                 135                 140                 


Gly Ser Gly Asp Leu Met Pro Trp Asn Leu Val Arg Ile Gly Leu Leu 
145                 150                 155                 160 


Arg Asp Gly Ala Gln Val Thr Val Phe Leu Leu Asp Thr Ser Val Gln 
                165                 170                 175     


Thr Asp His Arg Glu Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn 
            180                 185                 190         


Ser Met Pro Lys Glu Asp Gly Thr Arg Phe His Arg Ser Ala Ser Lys 
        195                 200                 205             


Cys Glu Ser His Gly Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp 
    210                 215                 220                 


Ala Gly Val Ala Arg Gly Val Ser Val Asn Thr Val Arg Val Leu Asn 
225                 230                 235                 240 


Cys Gln Gly Arg Gly Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr 
                245                 250                 255     


Ile Arg Ala Ser Leu Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu 
            260                 265                 270         


Leu Pro Phe Val Gly Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg 
        275                 280                 285             


Glu Met Val His Ser Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr 
    290                 295                 300                 


Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile 
305                 310                 315                 320 


Thr Val Gly Ala Ser Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr 
                325                 330                 335     


Thr Gly Thr Asn Leu Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu 
            340                 345                 350         


Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met 
        355                 360                 365             


Ser Gly Thr Ser Gln Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val 
    370                 375                 380                 


Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu 
385                 390                 395                 400 


Leu Arg Tyr His Ala Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro 
                405                 410                 415     


Pro Glu His Tyr Leu Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr 
            420                 425                 430         


Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys 
        435                 440                 445             


Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His 
    450                 455                 460                 


Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His 
465                 470                 475                 480 


Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala 
                485                 490                 495     


His His Gly Ile Gly Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys 
            500                 505                 510         


Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser Leu His Val Gly 
        515                 520                 525             


Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser 
    530                 535                 540                 


Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu 
545                 550                 555                 560 


His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His 
                565                 570                 575     


Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys His Leu Ile Glu His 
            580                 585                 590         


His Gln Ser Glu Phe Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser 
        595                 600                 605             


Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His Gly Ser Val Thr His 
    610                 615                 620                 


Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly 
625                 630                 635                 640 


Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu 
                645                 650                 655     


Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu 
            660                 665                 670         


Val Leu Phe Gln Gly Pro Gly His His His His His His Ser Ala Trp 
        675                 680                 685             


Ser His Pro Gln Phe Glu Lys 
    690                 695 


<210>  92
<211>  1149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  92

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Lys Asn 
            660                 665                 670         


Leu Asp Cys Trp Val Asp Asn Glu Glu Asp Ile Asp Val Ile Leu Lys 
        675                 680                 685             


Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile Ile Ser Asp 
    690                 695                 700                 


Ile Ser Gly Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp Ala Gln Leu 
705                 710                 715                 720 


Val Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn Glu Ser 
                725                 730                 735     


Ser Glu Val Ile Val His Lys Ala Met Asp Ile Glu Tyr Asn Asp Met 
            740                 745                 750         


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
        755                 760                 765             


Ala Ser His Leu Glu Gln Tyr Gly Thr Asn Glu Tyr Ser Ile Ile Ser 
    770                 775                 780                 


Ser Met Lys Lys His Ser Leu Ser Ile Gly Ser Gly Trp Ser Val Ser 
785                 790                 795                 800 


Leu Lys Gly Asn Asn Leu Ile Trp Thr Leu Lys Asp Ser Ala Gly Glu 
                805                 810                 815     


Val Arg Gln Ile Thr Phe Arg Asp Leu Pro Asp Lys Phe Asn Ala Tyr 
            820                 825                 830         


Leu Ala Asn Lys Trp Val Phe Ile Thr Ile Thr Asn Asp Arg Leu Ser 
        835                 840                 845             


Ser Ala Asn Leu Tyr Ile Asn Gly Val Leu Met Gly Ser Ala Glu Ile 
    850                 855                 860                 


Thr Gly Leu Gly Ala Ile Arg Glu Asp Asn Asn Ile Thr Leu Lys Leu 
865                 870                 875                 880 


Asp Arg Cys Asn Asn Asn Asn Gln Tyr Val Ser Ile Asp Lys Phe Arg 
                885                 890                 895     


Ile Phe Cys Lys Ala Leu Asn Pro Lys Glu Ile Glu Lys Leu Tyr Thr 
            900                 905                 910         


Ser Tyr Leu Ser Ile Thr Phe Leu Arg Asp Phe Trp Gly Asn Pro Leu 
        915                 920                 925             


Arg Tyr Asp Thr Glu Tyr Tyr Leu Ile Pro Val Ala Ser Ser Ser Lys 
    930                 935                 940                 


Asp Val Gln Leu Lys Asn Ile Thr Asp Tyr Met Tyr Leu Thr Asn Ala 
945                 950                 955                 960 


Pro Ser Tyr Thr Asn Gly Lys Leu Asn Ile Tyr Tyr Arg Arg Leu Tyr 
                965                 970                 975     


Asn Gly Leu Lys Phe Ile Ile Lys Arg Tyr Thr Pro Asn Asn Glu Ile 
            980                 985                 990         


Asp Ser Phe Val Lys Ser Gly Asp  Phe Ile Lys Leu Tyr  Val Ser Tyr 
        995                 1000                 1005             


Asn Asn  Asn Glu His Ile Val  Gly Tyr Pro Lys Asp  Gly Asn Ala 
    1010                 1015                 1020             


Phe Asn  Asn Leu Asp Arg Ile  Leu Arg Val Gly Tyr  Asn Ala Pro 
    1025                 1030                 1035             


Gly Ile  Pro Leu Tyr Lys Lys  Met Glu Ala Val Lys  Leu Arg Asp 
    1040                 1045                 1050             


Leu Lys  Thr Tyr Ser Val Gln  Leu Lys Leu Tyr Asp  Asp Lys Asn 
    1055                 1060                 1065             


Ala Ser  Leu Gly Leu Val Gly  Thr His Asn Gly Gln  Ile Gly Asn 
    1070                 1075                 1080             


Asp Pro  Asn Arg Asp Ile Leu  Ile Ala Ser Asn Trp  Tyr Phe Asn 
    1085                 1090                 1095             


His Leu  Lys Asp Lys Ile Leu  Gly Cys Asp Trp Tyr  Phe Val Pro 
    1100                 1105                 1110             


Thr Asp  Glu Gly Trp Thr Asn  Asp Gly Ser Gly Leu  Glu Val Leu 
    1115                 1120                 1125             


Phe Gln  Gly Pro Gly His His  His His His His Ser  Ala Trp Ser 
    1130                 1135                 1140             


His Pro  Gln Phe Glu Lys 
    1145                 


<210>  93
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  93

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Arg Lys Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Phe Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Gln Asp 
305                 310                 315                 320 


Arg Pro Leu Thr Leu Gly Thr Leu Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Ile Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  94
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  94

Met Ile Ala Ser Lys Lys Thr Thr Asp Phe Trp Lys Met Ser Phe Phe 
1               5                   10                  15      


Leu Val Met Cys Leu Ala Ala Leu Ala Ala Cys Asp Asn Pro Glu Glu 
            20                  25                  30          


Lys Pro Val Asn Ala Pro Val Ile Val His Pro Pro Pro Pro Arg Thr 
        35                  40                  45              


Glu Arg Val Ala Glu Phe Leu Arg Cys Thr Lys Ser Ala Trp Cys Ile 
    50                  55                  60                  


Pro Asp Gln Tyr Leu Val Val Leu Gln Glu Gly Ala His Asp Ser His 
65                  70                  75                  80  


Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala Arg Ser Arg 
                85                  90                  95      


His Thr Ile His Ile Thr His Thr Tyr Ser Gly Ala Phe Cys Gly Phe 
            100                 105                 110         


Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu Lys Leu Pro 
        115                 120                 125             


His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln Ser Ile 
    130                 135                 140                 


Pro Trp Asn Leu Gln Arg Ile Met Gln Thr Lys His Glu Thr Gly Lys 
145                 150                 155                 160 


Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe Leu Leu Asp 
                165                 170                 175     


Thr Ser Ile Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val Met Val 
            180                 185                 190         


Thr Asp Phe Asn Ser Val Pro Lys Glu Asp Gly Thr Arg Phe His Arg 
        195                 200                 205             


Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly Val Leu 
    210                 215                 220                 


Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Gly Val Asn Thr Val 
225                 230                 235                 240 


Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala Leu Ala 
                245                 250                 255     


Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val Arg Pro 
            260                 265                 270         


Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr Leu Asn 
        275                 280                 285             


Ile Ala Cys Gln Glu Met Val His Ser Gly Ala Val Leu Ile Ala Ala 
    290                 295                 300                 


Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala Ser Glu 
305                 310                 315                 320 


Pro Glu Val Ile Thr Ile Gly Ala Thr Asn Ala Ala Asp Gln Leu Leu 
                325                 330                 335     


Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp Val Phe 
            340                 345                 350         


Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr Cys 
        355                 360                 365             


Phe Val Ser Lys Arg Gly Thr Ser Gln Ala Ala Ala His Ala Ala Gly 
    370                 375                 380                 


Ile Ala Ala Val Leu Leu Asn Ala His Pro Ser Ala Ser Pro Ala Glu 
385                 390                 395                 400 


Val Leu Gln Leu Leu Arg Tyr His Ser Val Gln His Val Ile Asn Pro 
                405                 410                 415     


Asp Ser Leu Pro Pro Glu His Tyr His Thr Thr Pro Asp Met Val Ala 
            420                 425                 430         


Ala Leu Pro Lys Ser Ala Ala Thr Gly Glu Thr Leu Leu Cys Arg Ser 
        435                 440                 445             


Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala 
    450                 455                 460                 


His Cys Arg Arg Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro 
465                 470                 475                 480 


Asn Gly Val His Ala Gly Glu Lys Ile Glu Ile Arg Asp Gly Gln Lys 
                485                 490                 495     


Val Cys Glu Ser His His Ala Ile Gly Gly His Gly Val Tyr Ala Ile 
            500                 505                 510         


Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser 
        515                 520                 525             


Leu His Val Gly Val Asp Ala Glu Cys Pro Ser Gln Glu Tyr Gln Leu 
    530                 535                 540                 


Thr Gly Cys Ser Ser His Tyr Ile Arg Ser His Asp Thr Ala Gln Pro 
545                 550                 555                 560 


Ser Arg Leu Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly 
                565                 570                 575     


Gly Thr Ser His Ala Ser Cys Cys Arg Ala Pro Asn Leu Glu Cys His 
            580                 585                 590         


Leu Ile Glu Phe Thr Arg Gln Val Glu Val Ser Cys Glu Asp Ser Trp 
        595                 600                 605             


Thr Leu Thr Trp Cys Ile Ala Ala Ser His Gly Ser Val Thr His Gly 
    610                 615                 620                 


Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln Met Phe Gly Glu His 
625                 630                 635                 640 


Lys Gly Thr Ala Ala Leu Ala Ile Cys Cys Arg Phe Arg Pro Leu Asp 
                645                 650                 655     


Gln Gln Ser Asn Lys Asn His Glu Gln Asn Thr 
            660                 665         


<210>  95
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  95

Met Arg Arg Thr Ser Ala Trp Val Gly Trp Val Leu Cys Leu Cys Thr 
1               5                   10                  15      


Ser Leu Ala Ala Ser Ala Gln Asp Tyr Pro Asp Gly Asp Glu Met Ile 
            20                  25                  30          


Leu Asp Met Phe Ser Glu Asp Gly Thr Lys Pro Glu Pro Arg Ala Val 
        35                  40                  45              


Pro Thr Ala Glu Phe Leu Lys Cys Asn Lys Ala Ala Trp Arg Val His 
    50                  55                  60                  


Gly Gln Tyr Leu Val Val Leu Arg Gln Gly Thr His Gly Ser His Val 
65                  70                  75                  80  


Gln Arg Thr Ile Arg Arg Leu Arg Ala Lys Ala Ala Arg Arg Gly Gln 
                85                  90                  95      


Leu Leu Glu Ile Leu His Thr Tyr Ser Ala Ala Leu His Gly Phe Met 
            100                 105                 110         


Val Lys Met Ser Ser Asp Val Leu His Leu Ala Leu Lys Leu Pro Gln 
        115                 120                 125             


Val His Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln Ser Ile Pro 
    130                 135                 140                 


Trp Asn Leu Gln Arg Leu Leu Gln Pro His Gly Gly Ser Ser Glu Asn 
145                 150                 155                 160 


Gly Thr Tyr Arg Pro Pro Asn Asp Gly Gly Met Ala Leu Val Tyr Leu 
                165                 170                 175     


Leu Asp Gly Ser Val Gln Ser Asp His Arg Glu Val Glu Gly Arg Val 
            180                 185                 190         


Leu Ile Thr Asp Phe Asn Ser Val Pro Lys Glu Asp Gly Thr Arg Phe 
        195                 200                 205             


His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly 
    210                 215                 220                 


Val Val Thr Gly Arg Asp Ala Gly Val Ala Arg Gly Ala Gly Val Asn 
225                 230                 235                 240 


Leu Val Arg Ile Leu Asn Cys Gln Gly Lys Gly Ser Val Ser Gly Ala 
                245                 250                 255     


Leu Ala Gly Leu Glu Tyr Ile Gln Ser Thr Leu Leu Ala Arg Pro Val 
            260                 265                 270         


Asp Ala Val Val Val Leu Leu Pro Phe Ser Gly Gly Phe Ser Arg Ser 
        275                 280                 285             


Leu Asn Ala Ala Cys Arg Asp Met Val Ala Lys Gly Ala Val Val Ile 
    290                 295                 300                 


Ala Ala Ala Gly Asn Tyr Arg Asp Asp Ala Cys Phe Tyr Ser Pro Ala 
305                 310                 315                 320 


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Val Asn Ser Val Asp Gln 
                325                 330                 335     


Leu Met Ser Gln Gly Ala Gly Gly Thr Asn Phe Gly Arg Cys Ile Asp 
            340                 345                 350         


Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
        355                 360                 365             


Thr Cys Phe Val Ser Arg Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
    370                 375                 380                 


Ala Gly Ile Ala Ala Val Ile Leu Ser Ser Asn Gln Asn Val Ser Pro 
385                 390                 395                 400 


Val Gln Val Met Gln Met Met Leu His Tyr Ser Ser Ser His Thr Ile 
                405                 410                 415     


Asn Phe Leu Ser Leu Pro Asp Ser His Arg Leu Ile Ser Pro Asn Leu 
            420                 425                 430         


Val Ala Ala Met Pro Pro Ala Asn Ser Ala Lys Glu Leu Leu Cys Arg 
        435                 440                 445             


Ser Val Trp Ser Lys Arg Ser Gly Val Thr Ser Ser Asp Gln Ala Val 
    450                 455                 460                 


Ser Arg Cys Arg Leu Gly Glu Glu Met Met Ser Cys Ser Ser Tyr Thr 
465                 470                 475                 480 


Leu Asp Gly Val His Ala Gly Glu Thr Ile Ser Glu Ser Ser Gly Gln 
                485                 490                 495     


Met Glu Cys Val Ala Phe Asn Ala Leu Gly Gly Glu Gly Val Tyr Ala 
            500                 505                 510         


Val Ala Arg Cys Cys Val Ile Gly Gly Leu Gln Cys Gln Val His Ala 
        515                 520                 525             


Ser Pro Glu Cys Val Ala Thr Gln His His Leu Thr Gly Cys Thr Leu 
    530                 535                 540                 


Arg Ser Ala Ala Gly Ile Ser Ala Asp Ser Arg Pro His Gly Ser Asp 
545                 550                 555                 560 


Arg Arg Arg Cys Val Gly Ser Ser Gly Ala Thr Ser His Ala Val Cys 
                565                 570                 575     


Cys His Ala Pro Ser Leu Glu Cys Arg Leu Met Glu Lys Ile Ser Ala 
            580                 585                 590         


Asp Lys Asp Gln Val Glu Leu Ser Cys Pro Ser Gly Trp Thr Leu Thr 
        595                 600                 605             


Asp Cys Ser Ala Val Ser Pro Gly Ser Val Ile Leu Ala Pro Val Ala 
    610                 615                 620                 


Lys Gly Asn Ser Cys His Val Gly Ser Ala Ser Gly Ala Gly Gly Ala 
625                 630                 635                 640 


Ala Gly Val Val Val Cys Cys Arg Val Arg Gln Pro Glu Gln Arg Arg 
                645                 650                 655     


Ala Ser Pro Pro Pro 
            660     


<210>  96
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  96

Met Arg Arg Thr Ser Ala Trp Val Gly Trp Val Leu Cys Leu Cys Thr 
1               5                   10                  15      


Ser Leu Ala Ala Ser Ala Gln Asp Tyr Pro Asp Gly Asp Glu Met Ile 
            20                  25                  30          


Leu Asp Met Phe Ser Glu Asp Gly Thr Lys Pro Glu Pro Arg Ala Val 
        35                  40                  45              


Pro Thr Ala Glu Phe Leu Lys Cys Asn Lys Ala Ala Trp Arg Val His 
    50                  55                  60                  


Gly Gln Tyr Leu Val Val Leu Arg Gln Gly Thr His Gly Ser His Val 
65                  70                  75                  80  


Gln Arg Thr Ile Arg Arg Leu Arg Ala Lys Ala Ala Arg Arg Gly Gln 
                85                  90                  95      


Leu Leu Glu Ile Leu His Thr Tyr Ser Ala Ala Leu His Gly Phe Met 
            100                 105                 110         


Val Lys Met Ser Ser Asp Val Leu His Leu Ala Leu Lys Leu Pro Gln 
        115                 120                 125             


Val His Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln Ser Ile Pro 
    130                 135                 140                 


Trp Asn Leu Gln Arg Leu Leu Gln Pro His Gly Gly Ser Ser Glu Ser 
145                 150                 155                 160 


Gly Thr Tyr Arg Pro Pro Asn Asp Gly Gly Met Ala Leu Val Tyr Leu 
                165                 170                 175     


Leu Asp Gly Ser Val Gln Ser Asp His Arg Glu Val Glu Gly Arg Val 
            180                 185                 190         


Leu Ile Thr Asp Phe Asn Ser Val Pro Lys Glu Asp Gly Thr Arg Phe 
        195                 200                 205             


His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly 
    210                 215                 220                 


Val Val Thr Gly Arg Asp Ala Gly Val Ala Arg Gly Ala Gly Val Asn 
225                 230                 235                 240 


Leu Val Arg Ile Leu Asn Cys Gln Gly Lys Gly Ser Val Ser Gly Ala 
                245                 250                 255     


Leu Ala Gly Leu Glu Tyr Ile Gln Ser Thr Leu Leu Ala Arg Pro Val 
            260                 265                 270         


Asp Ala Val Val Val Leu Leu Pro Phe Ser Gly Gly Phe Ser Arg Ser 
        275                 280                 285             


Leu Asn Ala Ala Cys Arg Asp Met Val Ala Lys Gly Ala Val Val Ile 
    290                 295                 300                 


Ala Ala Ala Gly Asn Tyr Arg Asp Asp Ala Cys Phe Tyr Ser Pro Ala 
305                 310                 315                 320 


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Val Asn Ser Val Asp Gln 
                325                 330                 335     


Leu Met Ser Gln Gly Ala Gly Gly Thr Asn Phe Gly Arg Cys Ile Asp 
            340                 345                 350         


Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
        355                 360                 365             


Thr Cys Phe Val Ser Arg Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
    370                 375                 380                 


Ala Gly Ile Ala Ala Val Ile Leu Ser Ser Asn Gln Gln Val Ser Pro 
385                 390                 395                 400 


Val Gln Val Met Gln Met Met Leu His Tyr Ser Ser Ser His Thr Ile 
                405                 410                 415     


Asn Phe Leu Ser Leu Pro Asp Ser His Arg Leu Ile Ser Pro Asn Leu 
            420                 425                 430         


Val Ala Ala Met Pro Pro Ala Asn Ser Ala Lys Glu Leu Leu Cys Arg 
        435                 440                 445             


Ser Val Trp Ser Lys Arg Ser Gly Val Thr Ser Ser Asp Gln Ala Val 
    450                 455                 460                 


Ser Arg Cys Arg Leu Gly Glu Glu Met Met Ser Cys Ser Ser Tyr Thr 
465                 470                 475                 480 


Leu Asp Gly Val His Ala Gly Glu Thr Ile Ser Glu Ser Ser Gly Gln 
                485                 490                 495     


Met Glu Cys Val Ala Phe Asn Ala Leu Gly Gly Glu Gly Val Tyr Ala 
            500                 505                 510         


Val Ala Arg Cys Cys Val Ile Gly Gly Leu Gln Cys Gln Val His Ala 
        515                 520                 525             


Ser Pro Glu Cys Val Ala Thr Gln His His Leu Thr Gly Cys Thr Leu 
    530                 535                 540                 


Arg Ser Ala Ala Gly Ile Ser Ala Asp Ser Arg Pro His Gly Ser Asp 
545                 550                 555                 560 


Arg Arg Arg Cys Val Gly Ser Ser Gly Ala Thr Ser His Ala Val Cys 
                565                 570                 575     


Cys His Ala Pro Ser Leu Glu Cys Arg Leu Met Glu Lys Ile Ser Ala 
            580                 585                 590         


Asp Lys Asp Gln Val Glu Leu Ser Cys Pro Ser Gly Trp Thr Leu Thr 
        595                 600                 605             


Asp Cys Ser Ala Val Ser Pro Gly Ser Val Ile Leu Ala Pro Val Ala 
    610                 615                 620                 


Lys Gly Asn Ser Cys His Val Gly Ser Ala Ser Gly Ala Gly Gly Ala 
625                 630                 635                 640 


Ala Gly Val Val Val Cys Cys Arg Val Arg Gln Pro Glu Gln Arg Arg 
                645                 650                 655     


Ala Ser Pro 
            


<210>  97
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  97

Met Arg Arg Thr Ser Ala Trp Val Gly Trp Ala Leu Cys Leu Cys Ala 
1               5                   10                  15      


Ser Leu Ala Ala Asn Ala Gln Asp Tyr Pro Glu Asp Asp Glu Met Ile 
            20                  25                  30          


Leu Asp Leu Ile Arg Glu Asp Gly Thr Gln Pro Glu Thr Gly Thr Glu 
        35                  40                  45              


Pro Ala Ala Glu Phe Leu Arg Cys Asn Lys Ala Ala Trp Arg Met Pro 
    50                  55                  60                  


Gly Lys Tyr Leu Val Ile Leu Arg Gln Gly Thr His Gly Ser His Val 
65                  70                  75                  80  


Gln Arg Thr Ile Arg Arg Leu Arg Ala Lys Ala Ala Arg Arg Ser Tyr 
                85                  90                  95      


Leu Leu Glu Ile Leu Gln Thr Tyr Ser Gly Ala Leu Lys Gly Phe Leu 
            100                 105                 110         


Val Lys Met Ser Ser Asp Val Leu His Leu Ala Val Lys Leu Pro His 
        115                 120                 125             


Val His Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln Ser Ile Pro 
    130                 135                 140                 


Trp Asn Leu Gln Arg Leu Leu Gln Pro Arg Gly Gly Thr Ser Glu Asn 
145                 150                 155                 160 


Gly Thr Tyr Gln Pro Pro Asn Asp Gly Ala Met Ala Glu Val Tyr Leu 
                165                 170                 175     


Met Asp Gly Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
            180                 185                 190         


Leu Ile Thr Asp Phe Asn Asp Val Pro Lys Glu Asp Gly Thr Arg Phe 
        195                 200                 205             


His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Met Ala Gly 
    210                 215                 220                 


Val Val Thr Gly Arg Asp Ala Gly Val Ala Arg Gly Ala Asp Val Asn 
225                 230                 235                 240 


Leu Val Arg Ile Leu Asn Cys Gln Gly Lys Gly Ser Val Ser Gly Ala 
                245                 250                 255     


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Thr Leu Leu Ala Arg Pro Val 
            260                 265                 270         


Glu Ala Val Val Val Leu Leu Pro Phe Ile Gly Gly Phe Ser Arg Ser 
        275                 280                 285             


Leu Asn Thr Ala Cys Arg Asp Met Val Ala Asn Gly Ala Val Val Ile 
    290                 295                 300                 


Ala Ala Ala Gly Asn Tyr Arg Asp Asp Ala Cys Met Tyr Ser Pro Ala 
305                 310                 315                 320 


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Val Asn Ser Ala Asp Gln 
                325                 330                 335     


Leu Met Ser Gln Gly Ala Gly Gly Thr Asn Val Gly Arg Cys Val Asp 
            340                 345                 350         


Phe Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
        355                 360                 365             


Thr Cys Phe Val Ser Arg Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
    370                 375                 380                 


Ala Gly Ile Ala Ala Val Ile Leu Ser Ser Ser Gln Asn Met Ser Pro 
385                 390                 395                 400 


Val His Val Leu Gln Thr Met Leu His His Ser Ile Ser Asn Thr Ile 
                405                 410                 415     


Asn Leu Leu Ser Leu Ser Glu Thr His Tyr Leu Thr Thr Pro Asn Leu 
            420                 425                 430         


Val Ala Ala Met Pro Pro Thr Asn Arg Thr Asn Ala Asp Gly Glu Leu 
        435                 440                 445             


Leu Cys Arg Ser Val Trp Ser Glu Lys Ser Gly Val Ala Ser Ala Asp 
    450                 455                 460                 


Arg Ala Val Ser Arg Cys Arg Leu Gly Glu Glu Met Leu Gly Cys Ser 
465                 470                 475                 480 


Ser Tyr Thr Pro Asp Gly Val Arg Val Gly Glu Ser Ile Ala Ile Asn 
                485                 490                 495     


Gly Glu Arg Met Glu Cys Val Ala Tyr Asn Gly Pro Gly Gly Lys Gly 
            500                 505                 510         


Val Tyr Ala Val Ala Arg Cys Cys Ala Ile Gly Gly Leu Arg Cys Gln 
        515                 520                 525             


Val His Ala Ser Pro Lys Pro Gly Gln Asp Ala Glu Cys Ile Asp Pro 
    530                 535                 540                 


Gln His His Leu Thr Gly Cys Thr Ser Trp Ser Thr Thr Lys Thr Leu 
545                 550                 555                 560 


Ser Asp Ser Arg Pro His His Gly Asp Arg Arg Arg Cys Ile Val Lys 
                565                 570                 575     


Asn Gly Val Ala Ser His Ala Val Cys Cys His Ala Pro Ala Leu Gln 
            580                 585                 590         


Cys Leu Leu Met Glu Asn Thr Ser Ala Asp Lys Glu Gln Val Glu Val 
        595                 600                 605             


Ser Cys Pro Ser Gly Trp Thr Leu Thr Asp Cys Ser Ala Val Ser Gln 
    610                 615                 620                 


Asp Ser Ser Ile Leu Gly Pro Val Ala Lys Gly Asn Ser Cys Arg Val 
625                 630                 635                 640 


His Gly Ala Thr Thr Gly Ala Gly Gly Ala Ala Gly Ile Ala Val Cys 
                645                 650                 655     


Cys Arg Val Arg Pro Pro Glu Gln Pro Ala Ala Ala Pro His 
            660                 665                 670 


<210>  98
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  98

Met Arg Arg Thr Ser Ala Trp Val Gly Trp Ala Leu Cys Leu Cys Ala 
1               5                   10                  15      


Ser Leu Ala Ala Asn Ala Gln Asp Tyr Pro Glu Asp Asp Glu Met Ile 
            20                  25                  30          


Leu Asp Leu Ile Arg Glu Asp Gly Thr Gln Pro Glu Thr Gly Thr Glu 
        35                  40                  45              


Pro Ala Ala Glu Phe Leu Arg Cys Asn Lys Ala Ala Trp Arg Met Pro 
    50                  55                  60                  


Gly Lys Tyr Leu Val Ile Leu Arg Gln Gly Thr His Gly Ser His Val 
65                  70                  75                  80  


Gln Arg Thr Ile Arg Arg Leu Arg Ala Lys Ala Ala Arg Arg Ser Tyr 
                85                  90                  95      


Leu Leu Glu Ile Leu Gln Thr Tyr Ser Gly Ala Leu Lys Gly Phe Leu 
            100                 105                 110         


Val Lys Met Ser Ser Asp Val Leu His Leu Ala Val Lys Leu Pro His 
        115                 120                 125             


Val His Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln Ser Ile Pro 
    130                 135                 140                 


Trp Asn Leu Gln Arg Leu Leu Gln Pro Arg Gly Gly Thr Ser Glu Ser 
145                 150                 155                 160 


Gly Thr Tyr Gln Pro Pro Asn Asp Gly Ala Met Ala Glu Val Tyr Leu 
                165                 170                 175     


Met Asp Gly Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
            180                 185                 190         


Leu Ile Thr Asp Phe Asn Asp Val Pro Lys Glu Asp Gly Thr Arg Phe 
        195                 200                 205             


His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Met Ala Gly 
    210                 215                 220                 


Val Val Thr Gly Arg Asp Ala Gly Val Ala Arg Gly Ala Asp Val Asn 
225                 230                 235                 240 


Leu Val Arg Ile Leu Asn Cys Gln Gly Lys Gly Ser Val Ser Gly Ala 
                245                 250                 255     


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Thr Leu Leu Ala Arg Pro Val 
            260                 265                 270         


Glu Ala Val Val Val Leu Leu Pro Phe Ile Gly Gly Phe Ser Arg Ser 
        275                 280                 285             


Leu Asn Thr Ala Cys Arg Asp Met Val Ala Asn Gly Ala Val Val Ile 
    290                 295                 300                 


Ala Ala Ala Gly Asn Tyr Arg Asp Asp Ala Cys Met Tyr Ser Pro Ala 
305                 310                 315                 320 


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Val Asn Ser Ala Asp Gln 
                325                 330                 335     


Leu Met Ser Gln Gly Ala Gly Gly Thr Asn Val Gly Arg Cys Val Asp 
            340                 345                 350         


Phe Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
        355                 360                 365             


Thr Cys Phe Val Ser Arg Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
    370                 375                 380                 


Ala Gly Ile Ala Ala Val Ile Leu Ser Ser Ser Gln Gln Met Ser Pro 
385                 390                 395                 400 


Val His Val Leu Gln Thr Met Leu His His Ser Ile Ser Asn Thr Ile 
                405                 410                 415     


Asn Leu Leu Ser Leu Ser Glu Thr His Tyr Leu Thr Thr Pro Asn Leu 
            420                 425                 430         


Val Ala Ala Met Pro Pro Thr Gln Arg Thr Asn Ala Asp Gly Glu Leu 
        435                 440                 445             


Leu Cys Arg Ser Val Trp Ser Glu Lys Ser Gly Val Ala Ser Ala Asp 
    450                 455                 460                 


Arg Ala Val Ser Arg Cys Arg Leu Gly Glu Glu Met Leu Gly Cys Ser 
465                 470                 475                 480 


Ser Tyr Thr Pro Asp Gly Val Arg Val Gly Glu Ser Ile Ala Ile Asn 
                485                 490                 495     


Gly Glu Arg Met Glu Cys Val Ala Tyr Asn Gly Pro Gly Gly Lys Gly 
            500                 505                 510         


Val Tyr Ala Val Ala Arg Cys Cys Ala Ile Gly Gly Leu Arg Cys Gln 
        515                 520                 525             


Val His Ala Ser Pro Lys Pro Gly Gln Asp Ala Glu Cys Ile Asp Pro 
    530                 535                 540                 


Gln His His Leu Thr Gly Cys Thr Ser Trp Ser Thr Thr Lys Thr Leu 
545                 550                 555                 560 


Ser Asp Ser Arg Pro His His Gly Asp Arg Arg Arg Cys Ile Val Lys 
                565                 570                 575     


Asn Gly Val Ala Ser His Ala Val Cys Cys His Ala Pro Ala Leu Gln 
            580                 585                 590         


Cys Leu Leu Met Glu Thr Ser Ala Asp Lys Glu Gln Val Glu Val Ser 
        595                 600                 605             


Cys Pro Ser Gly Trp Thr Leu Thr Asp Cys Ser Ala Val Ser Gln Asp 
    610                 615                 620                 


Ser Ser Ile Leu Gly Pro Val Ala Lys Gly Asn Ser Cys Arg Val His 
625                 630                 635                 640 


Gly Ala Thr Thr Gly Ala Gly Gly Ala Ala Gly Ile Ala Val Cys Cys 
                645                 650                 655     


Arg Val Arg Pro Pro Glu Gln Pro Ala Ala Ala 
            660                 665         


<210>  99
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  99

Met Arg Lys Met Cys Pro Ile Ser Gly Trp Ile Gly Cys Ala Leu Cys 
1               5                   10                  15      


Leu Cys Ala Ser Leu Val Val Cys Ala Gln Asp His Thr Glu Glu Asp 
            20                  25                  30          


Asp Met Ile Leu Glu Met Ile Leu Asp Asp Gly Leu Gln Ala Glu Ala 
        35                  40                  45              


Gly Asp Ala Pro Ser Ala Gln Phe Leu Lys Cys Asn Lys Ala Ala Trp 
    50                  55                  60                  


Arg Ile Pro Gly Gln Tyr Val Val Val Leu His Arg Gly Thr His Glu 
65                  70                  75                  80  


Ser Gln Val Gln Arg Thr Ile Arg Arg Leu Arg Ala Arg Ala Ala Arg 
                85                  90                  95      


Gly Gly Phe Pro Leu Glu Ile Leu His Thr Tyr Ser Gly Val Leu Gln 
            100                 105                 110         


Gly Phe Leu Val Lys Met Ser His Asp Ala Leu Asn Leu Ala Val Lys 
        115                 120                 125             


Leu Pro His Val His Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln 
    130                 135                 140                 


Ser Ile Pro Trp Asn Leu Gln Arg Leu Leu Arg Pro His Ala Gly Ile 
145                 150                 155                 160 


Ser Val Ser Gly Thr Tyr Leu Pro Pro Asn Asp Gly Gly Met Ala Glu 
                165                 170                 175     


Val Tyr Leu Met Asp Gly Ser Val Gln Gln Asp His Arg Glu Ile Glu 
            180                 185                 190         


Gly Lys Val Leu Ile Thr Asp Phe Asn Ser Val Pro Lys Glu Asp Gly 
        195                 200                 205             


Thr Arg Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His 
    210                 215                 220                 


Val Ala Gly Val Val Thr Gly Arg Asp Ala Gly Val Ala Arg Gly Ala 
225                 230                 235                 240 


Gly Val Asn Leu Val Arg Ile Leu Asn Cys Gln Gly Lys Gly Ser Val 
                245                 250                 255     


Ser Gly Ala Leu Ser Gly Leu Glu Tyr Ile Arg Ala Thr Leu Leu Ala 
            260                 265                 270         


Arg Pro Val Asp Ala Ala Val Val Leu Leu Pro Phe Ile Gly Gly Phe 
        275                 280                 285             


Ser Arg Ser Leu Asn Thr Ala Cys Arg Gln Leu Val Ala His Gly Ala 
    290                 295                 300                 


Val Val Ile Ala Ala Ala Gly Asn Tyr Arg Glu Asp Ala Cys Met Tyr 
305                 310                 315                 320 


Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Val Asn Ser 
                325                 330                 335     


Ala Asp His Leu Met Ser Gln Gly Ala Gly Gly Ser Asn Phe Gly Pro 
            340                 345                 350         


Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly 
        355                 360                 365             


Asp Cys Ser Thr Cys Phe Val Ser Arg Ser Gly Thr Ser Gln Ser Ala 
    370                 375                 380                 


Ala His Ala Ala Gly Ile Ala Ala Val Ile Leu Ser Ser Asn Gln Lys 
385                 390                 395                 400 


Ala Ser Pro Leu Gln Val Leu His Thr Met Leu His Tyr Ser Ile Ser 
                405                 410                 415     


Asp Thr Ile Asn Phe Leu Pro Leu Ser Glu Thr His Arg Leu Thr Thr 
            420                 425                 430         


Pro Asn Leu Val Ala Ala Met Pro Ser Ala Asp Asn Pro Thr Pro Asn 
        435                 440                 445             


Gly Glu Leu Val Cys Arg Ser Val Trp Ser Glu Arg Ser Gly Leu Ser 
    450                 455                 460                 


Gly Gly Asp Thr Ala Val Ser Arg Cys Arg Val Gly Glu Glu Leu Met 
465                 470                 475                 480 


Gly Cys Ser Ser Tyr Ala Pro Asp Gly Thr Arg Val Gly Glu Thr Val 
                485                 490                 495     


Thr Glu Ser Arg Gly Arg Met Glu Cys Thr Ala Phe Asn Gly Pro Ala 
            500                 505                 510         


Gly Thr Gly Val Tyr Ala Val Ala Arg Cys Cys Ala Ile Ser Gly Leu 
        515                 520                 525             


Arg Cys Gln Ala His Ala Ser Pro Glu Pro Gly Gln Asp Ala Gln Cys 
    530                 535                 540                 


Ala Gly Pro Gln His His Leu Thr Gly Cys Thr Thr Trp Ser Thr Ala 
545                 550                 555                 560 


Glu Ile Leu Ser Asp Ser Arg Pro His His Gly Gly Arg Arg Gly Cys 
                565                 570                 575     


Leu Ala Lys Gly Arg Ala Thr Ser His Ala Val Cys Cys His Ala Pro 
            580                 585                 590         


Thr Leu Gln Cys His Leu Leu Glu Ala Thr Pro Ser Asp Ala Asp Gln 
        595                 600                 605             


Met Ser Cys Pro Ser Gly Trp Thr Leu Thr Asp Cys Ser Ala Val Ser 
    610                 615                 620                 


Arg Asp Ala Ala Val Val Gly Ser Val Pro Gln Gly Asn Gly Cys Arg 
625                 630                 635                 640 


Val His Asn Ala Gly Arg Val Glu Ala Ala Gly Val Ala Val Cys Cys 
                645                 650                 655     


Arg Val Ala Pro Pro Asp Pro Pro Ala Thr Thr 
            660                 665         


<210>  100
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  100

Met Leu Lys Lys Val Leu Ser Cys Cys Ile Ala Ala Thr Phe Gly Ile 
1               5                   10                  15      


Tyr Ser Ala Ser Ser Leu Ala Gln Ser Ser Ile Pro Trp Gly Leu Asp 
            20                  25                  30          


Arg Ile Asp Gln Arg Asn Leu Pro Leu Asp Arg Asn Tyr Asn Ala Asn 
        35                  40                  45              


Phe Asp Gly Phe Gly Val Thr Ala Tyr Val Ile Asp Thr Gly Val Asn 
    50                  55                  60                  


Asn Asp His Arg Glu Ile Glu Gly Arg Ser Val Ser Gly Tyr Asp Gly 
65                  70                  75                  80  


Thr Arg Phe His Ala Asp Ala Ser Lys Cys Glu Ser His Gly Thr His 
                85                  90                  95      


Val Ala Gly Thr Ile Gly Gly Arg Asp Ala Gly Val Ala Lys Asn Val 
            100                 105                 110         


Asn Ile Val Gly Val Arg Val Leu Ser Cys Ser Gly Ser Gly Thr Thr 
        115                 120                 125             


Ser Gly Val Ile Ser Gly Val Asp Trp Val Ala Gln Gln Ala Ser Gly 
    130                 135                 140                 


Pro Ser Val Ala Ser Met Ser Leu Gly Gly Gly Gln Ser Thr Ala Leu 
145                 150                 155                 160 


Asp Ser Ala Val Gln Gly Ala Ile Gln Ser Gly Val Ser Phe Met Leu 
                165                 170                 175     


Ala Ala Gly Asn Ser Asn Ala Asp Ala Cys Gln Thr Ser Pro Ala Arg 
            180                 185                 190         


Val Pro Ser Gly Val Thr Val Gly Ser Thr Thr Ser Ser Asp Ser Arg 
        195                 200                 205             


Ser Ser Phe Ser Asn Trp Gly Ser Cys Val Asp Val Phe Ala Pro Gly 
    210                 215                 220                 


Glu Asp Ile Ile Ser Ala Ser Tyr Asp Cys Ser Thr Cys Phe Val Ser 
225                 230                 235                 240 


Ile Ser Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Val Ala Ala 
                245                 250                 255     


Leu Tyr Leu Gln Glu Asn Asn Gly Leu Thr Pro Leu Gln Leu Thr Gly 
            260                 265                 270         


Leu Leu Asn Ser Arg Ala Ser Glu Asn Lys Val Ser Asp Thr Arg Gly 
        275                 280                 285             


Thr Thr Asn Lys Leu Leu Tyr Ser Leu Ala Asp Ser Gly Cys Glu Pro 
    290                 295                 300                 


Asp Cys Gly Gly Pro 
305                 


<210>  101
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  101

Met Leu Lys Lys Val Leu Ser Cys Cys Ile Ala Ala Thr Phe Gly Ile 
1               5                   10                  15      


Tyr Ser Ala Ser Ser Leu Ala Ala Thr Gln Thr Ser Ile Pro Trp Gly 
            20                  25                  30          


Leu Asp Arg Ile Asp Gln Arg Thr Leu Pro Leu Ser Gly Thr Phe Thr 
        35                  40                  45              


Tyr Ser Asn Thr Gly Ser Gly Val Asn Ala Tyr Ile Ile Asp Thr Gly 
    50                  55                  60                  


Ile Arg Val Asp His Arg Glu Ile Glu Gly Arg Ala Thr Ala Val Phe 
65                  70                  75                  80  


Asp Gly Thr Arg Phe His Gln Gln Ala Ser Lys Cys Glu Ser His Gly 
                85                  90                  95      


Thr His Val Ala Gly Thr Val Gly Gly Arg Asp Ala Gly Val Ala Lys 
            100                 105                 110         


Ser Val Arg Leu Tyr Ala Val Arg Val Leu Ser Cys Ser Gly Ser Gly 
        115                 120                 125             


Ser Asn Ser Gly Val Ile Ala Gly Val Asp Trp Val Arg Gln Asn Ala 
    130                 135                 140                 


Arg Arg Pro Ala Val Ala Ser Met Ser Leu Gly Gly Gly Ala Ser Ser 
145                 150                 155                 160 


Ala Leu Asp Thr Ala Val Asn Asn Ala Ile Asn Ala Gly Ile Thr Phe 
                165                 170                 175     


Ala Leu Ala Ala Gly Asn Ser Asn Arg Asp Ala Cys Gln Phe Ser Pro 
            180                 185                 190         


Ala Arg Val Thr Ala Gly Ile Thr Val Gly Ala Thr Thr Ser Thr Asp 
        195                 200                 205             


Ala Arg Ala Ser Tyr Ser Asn Tyr Gly Ser Cys Leu Asp Val Phe Ala 
    210                 215                 220                 


Pro Gly Glu Asp Ile Ile Ser Ala Ser Ile Asp Cys Ser Thr Cys Phe 
225                 230                 235                 240 


Val Ser Ile Ser Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Val 
                245                 250                 255     


Ala Ala Leu Tyr Leu Gln Ser Asn Pro Ser Ala Ser Pro Ala Thr Val 
            260                 265                 270         


Arg Asn Ala Ile Val Gly Gln Ala Thr Ser Gly Val Val Ser Asn Ala 
        275                 280                 285             


Gly Arg Arg Ser Pro Asn Leu Leu Leu Tyr Ser Asn Tyr Glu Asn Leu 
    290                 295                 300                 


Tyr 
305 


<210>  102
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  102

Ala Asp Gln Pro Ser Ile Pro Trp Gly Ile Asp Arg Ile Asp Gln Arg 
1               5                   10                  15      


Asn Leu Pro Leu Asp Asn Asn Tyr His Thr Asp Tyr Asp Gly Ser Gly 
            20                  25                  30          


Val Thr Ala Phe Val Ile Asp Thr Gly Val Leu Asn Asp His Arg Glu 
        35                  40                  45              


Ile Glu Gly Arg Ala Ser Ser Gly Tyr Asp Gly Thr Arg Phe His Tyr 
    50                  55                  60                  


Asp Ala Ser Lys Cys Glu Ser His Gly Thr His Val Ala Gly Thr Ile 
65                  70                  75                  80  


Gly Gly Arg Asp Ala Gly Val Ala Lys Asn Val Asn Val Val Gly Val 
                85                  90                  95      


Arg Val Leu Asn Cys Ser Gly Ser Gly Ser Asn Ser Gly Val Ile Ala 
            100                 105                 110         


Gly Ile Asn Trp Val Lys Asn Asn Ala Ser Gly Pro Ala Val Ala Asn 
        115                 120                 125             


Met Ser Leu Gly Gly Gly Ala Ser Gln Ala Thr Asp Asp Ala Val Asn 
    130                 135                 140                 


Ala Ala Val Ala Ala Gly Ile Thr Phe Val Val Ala Ala Gly Asn Asp 
145                 150                 155                 160 


Asn Ser Asn Ala Cys Asn Tyr Ser Pro Ala Arg Ala Ala Asp Ala Ile 
                165                 170                 175     


Thr Val Gly Ser Thr Thr Ser Asn Asp Ser Arg Ser Ser Phe Ser Asn 
            180                 185                 190         


Tyr Gly Thr Cys Leu Asp Ile Tyr Ala Pro Gly Glu Asp Ile Ile Ser 
        195                 200                 205             


Ala Ser Tyr Asp Cys Ser Thr Cys Phe Val Ser Ile Ser Gly Thr Ser 
    210                 215                 220                 


Met Ala Ser Pro His Val Ala Gly Val Ala Ala Leu Tyr Leu Asp Glu 
225                 230                 235                 240 


Asn Pro Asn Leu Ser Pro Ala Gln Val Thr Asn Leu Leu Lys Thr Arg 
                245                 250                 255     


Ala Thr Ala Asp Lys Val Thr Asp Ala Lys Thr Gly Ser Pro Asn Lys 
            260                 265                 270         


Leu Leu Phe Ser Leu Ala 
        275             


<210>  103
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  103

Ala Asp Gln Pro Ser Ile Pro Trp Gly Ile Asp Arg Ile Asp Gln Arg 
1               5                   10                  15      


Asn Leu Pro Leu Asp Asn Asn Tyr His Thr Asp Tyr Asp Gly Ser Gly 
            20                  25                  30          


Val Thr Ala Phe Val Ile Asp Thr Gly Val Leu Asn Asp His Arg Glu 
        35                  40                  45              


Ile Glu Gly Arg Ala Ser Ser Gly Tyr Asp Gly Thr Arg Phe His Tyr 
    50                  55                  60                  


Asp Ala Ser Lys Cys Glu Ser His Gly Thr His Val Ala Gly Thr Ile 
65                  70                  75                  80  


Gly Gly Arg Asp Ala Gly Val Ala Lys Asn Val Asn Val Val Gly Val 
                85                  90                  95      


Arg Val Leu Asn Cys Gln Gly Ser Gly Ser Asn Ser Gly Val Ile Ala 
            100                 105                 110         


Gly Ile Asn Trp Val Lys Asn Gln Ala Ser Gly Pro Ala Val Ala Asn 
        115                 120                 125             


Met Ala Leu Gly Gly Gly Ala Ser Gln Ala Thr Asp Asp Ala Val Asn 
    130                 135                 140                 


Ala Ala Val Ala Ala Gly Ile Thr Phe Val Val Ala Ala Gly Asn Asp 
145                 150                 155                 160 


Asn Ser Asn Ala Cys Gln Tyr Ser Pro Ala Arg Ala Ala Asp Ala Ile 
                165                 170                 175     


Thr Val Gly Ser Thr Thr Ser Gln Asp Ser Arg Ser Ser Phe Ser Asn 
            180                 185                 190         


Tyr Gly Thr Cys Leu Asp Ile Tyr Ala Pro Gly Glu Asp Ile Ile Ser 
        195                 200                 205             


Ala Ser Tyr Asp Cys Ser Thr Cys Phe Val Ser Ile Ser Gly Thr Ser 
    210                 215                 220                 


Met Ala Ser Pro His Val Ala Gly Val Ala Ala Leu Tyr Leu Asp Glu 
225                 230                 235                 240 


Asn Pro Gln Leu Ser Pro Ala Gln Val Thr Asn Leu Leu Lys Thr Arg 
                245                 250                 255     


Ala Thr Ala Asp Lys Val Thr Asp Ala Lys Thr Gly Ser Pro Asn Lys 
            260                 265                 270         


Leu Leu Phe Ser Leu Ala 
        275             


<210>  104
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  104

Gln Ser Ser Ile Pro Trp Gly Leu Asp Arg Ile Asp Gln Arg Asn Leu 
1               5                   10                  15      


Pro Leu Asp Arg Asn Tyr Asn Ala Asn Phe Asp Gly Phe Gly Val Thr 
            20                  25                  30          


Ala Tyr Val Ile Asp Thr Gly Val Asn Asn Asp His Arg Glu Ile Glu 
        35                  40                  45              


Gly Arg Ser Val Ser Gly Tyr Asp Gly Thr Arg Phe His Ala Asp Ala 
    50                  55                  60                  


Ser Lys Cys Glu Ser His Gly Thr His Val Ala Gly Thr Ile Gly Gly 
65                  70                  75                  80  


Arg Asp Ala Gly Val Ala Lys Asn Val Asn Ile Val Gly Val Arg Val 
                85                  90                  95      


Leu Ser Cys Ser Gly Ser Gly Thr Thr Ser Gly Val Ile Ser Gly Val 
            100                 105                 110         


Asp Trp Val Ala Gln Gln Ala Ser Gly Pro Ser Val Ala Ser Met Ser 
        115                 120                 125             


Leu Gly Gly Gly Gln Ser Thr Ala Leu Asp Ser Ala Val Gln Gly Ala 
    130                 135                 140                 


Ile Gln Ser Gly Val Ser Phe Met Leu Ala Ala Gly Asn Ser Asn Ala 
145                 150                 155                 160 


Asp Ala Cys Gln Thr Ser Pro Ala Arg Val Pro Ser Gly Val Thr Val 
                165                 170                 175     


Gly Ser Thr Thr Ser Ser Asp Ser Arg Ser Ser Phe Ser Asn Trp Gly 
            180                 185                 190         


Ser Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser 
        195                 200                 205             


Tyr Asp Cys Ser Thr Cys Phe Val Ser Ile Ser Gly Thr Ser Met Ala 
    210                 215                 220                 


Thr Pro His Val Ala Gly Val Ala Ala Leu Tyr Leu Gln Glu Asn Asn 
225                 230                 235                 240 


Gly Leu Thr Pro Leu Gln Leu Thr Gly Leu Leu Asn Ser Arg Ala Ser 
                245                 250                 255     


Glu Asn Lys Val Ser Asp Thr Arg Gly Thr Thr Asn Lys Leu Leu Tyr 
            260                 265                 270         


Ser Leu Ala Asp Ser Gly Cys Glu Pro Asp Cys Gly Gly Pro 
        275                 280                 285     


<210>  105
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  105

Ala Tyr Thr Gln Gln Pro Ser Ile Pro Trp Gly Leu Gly Arg Ile Ser 
1               5                   10                  15      


His Arg Ser Lys Gly Ser Thr Thr Tyr Glu Tyr Asp Thr Ser Gly Gly 
            20                  25                  30          


Ser Gly Thr Cys Ala Tyr Val Ile Asp Thr Gly Val Glu Ala Asp His 
        35                  40                  45              


Arg Glu Ile Glu Gly Arg Ala Ser Gln Ile Lys Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Gln Ala Ser Lys Cys Glu Ser His Gly Thr His Cys Ala Gly Thr 
65                  70                  75                  80  


Ile Gly Ser Arg Asp Ala Gly Val Ala Lys Lys Thr Lys Ile Tyr Gly 
                85                  90                  95      


Val Lys Val Leu Asp Asn Ser Gly Ser Gly Ser Tyr Ser Gly Ile Ile 
            100                 105                 110         


Ser Gly Met Asp Phe Ala Val Gln Asp Ser Lys Ser Arg Ser Cys Pro 
        115                 120                 125             


Lys Gly Val Val Ala Ser Met Ser Leu Gly Gly Gly Lys Ala Gln Ser 
    130                 135                 140                 


Val Asn Asp Gly Ala Ala Ala Met Ile Arg Ala Gly Val Phe Leu Ala 
145                 150                 155                 160 


Val Ala Ala Gly Asn Asp Asn Ala Asn Ala Ala Gln Tyr Ser Pro Ala 
                165                 170                 175     


Ser Glu Pro Thr Val Cys Thr Val Gly Ala Thr Thr Ser Ser Asp Ala 
            180                 185                 190         


Arg Ser Ser Phe Ser Asn Tyr Gly Asn Leu Val Asp Ile Phe Ala Pro 
        195                 200                 205             


Gly Glu Asp Ile Ile Ser Ala Ser Ile Asp Cys Ser Thr Cys Phe Val 
    210                 215                 220                 


Ser Ile Ser Gly Thr Ser Met Ala Thr Pro His Ile Val Gly Leu Gly 
225                 230                 235                 240 


Ala Tyr Leu Ala Gly Leu Glu Gly Phe Pro Gly Ala Gln Ala Leu Cys 
                245                 250                 255     


Lys Arg Ile Gln Thr Leu Ser Thr Lys Asn Val Leu Thr Gly Ile Pro 
            260                 265                 270         


Ser Gly Thr Val Asn Tyr Leu Ala Phe Asn Gly Asn Pro Ser Gly 
        275                 280                 285         


<210>  106
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  106

Ala Thr Gln Ser Ser Ile Pro Trp Gly Leu Asp Arg Ile Asp Gln Arg 
1               5                   10                  15      


Asp Leu Pro Leu Ser Asn Ser Tyr Thr Tyr Thr Ala Thr Gly Arg Gly 
            20                  25                  30          


Val Asn Val Tyr Val Ile Asp Thr Gly Ile Arg Thr Asp His Arg Glu 
        35                  40                  45              


Ile Glu Gly Arg Ala Arg Val Gly Tyr Asp Gly Thr Arg Phe His Gln 
    50                  55                  60                  


Ala Ser Lys Cys Glu Ser His Gly Thr His Val Ala Gly Thr Ile Gly 
65                  70                  75                  80  


Gly Arg Asp Ala Gly Val Ala Lys Ala Val Asn Leu Tyr Ala Val Arg 
                85                  90                  95      


Val Leu Asp Cys Ser Gly Ser Gly Ser Thr Ser Gly Val Ile Ala Gly 
            100                 105                 110         


Val Asp Trp Val Thr Arg Asn His Arg Arg Pro Ala Val Ala Ser Met 
        115                 120                 125             


Ser Leu Gly Gly Gly Val Ser Thr Ala Leu Asp Asn Ala Val Lys Asn 
    130                 135                 140                 


Ser Ile Ala Ala Gly Val Val Tyr Ala Val Ala Ala Gly Asn Asp Asn 
145                 150                 155                 160 


Ala Asn Ala Cys Gln Tyr Ser Pro Ala Arg Val Ala Glu Ala Leu Thr 
                165                 170                 175     


Val Gly Ala Thr Thr Ser Ser Asp Ala Arg Ala Ser Phe Ser Asn Tyr 
            180                 185                 190         


Gly Ser Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        195                 200                 205             


Ser Tyr Asp Cys Ser Thr Cys Phe Val Ser Leu Ser Gly Thr Ser Met 
    210                 215                 220                 


Ala Thr Pro His Val Ala Gly Val Ala Ala Leu Tyr Leu Glu Gln Asn 
225                 230                 235                 240 


Pro Ser Ala Thr Pro Ala Ser Val Ala Ser Ala Ile Leu Asn Gly Ala 
                245                 250                 255     


Thr Thr Gly Arg Leu Ser Gly Ile Gly Ser Gly Ser Pro Asn Arg Leu 
            260                 265                 270         


Leu Tyr Ser Leu Leu 
        275         


<210>  107
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  107

Ala Thr Gln Thr Ser Ile Pro Trp Gly Leu Asp Arg Ile Asp Gln Arg 
1               5                   10                  15      


Thr Leu Pro Leu Ser Gly Thr Phe Thr Tyr Ser Asn Thr Gly Ser Gly 
            20                  25                  30          


Val Asn Ala Tyr Ile Ile Asp Thr Gly Ile Arg Val Asp His Arg Glu 
        35                  40                  45              


Ile Glu Gly Arg Ala Thr Ala Val Phe Asp Gly Thr Arg Phe His Gln 
    50                  55                  60                  


Gln Ala Ser Lys Cys Glu Ser His Gly Thr His Val Ala Gly Thr Val 
65                  70                  75                  80  


Gly Gly Arg Asp Ala Gly Val Ala Lys Ser Val Arg Leu Tyr Ala Val 
                85                  90                  95      


Arg Val Leu Ser Cys Ser Gly Ser Gly Ser Asn Ser Gly Val Ile Ala 
            100                 105                 110         


Gly Val Asp Trp Val Arg Gln Asn Ala Arg Arg Pro Ala Val Ala Ser 
        115                 120                 125             


Met Ser Leu Gly Gly Gly Ala Ser Ser Ala Leu Asp Thr Ala Val Asn 
    130                 135                 140                 


Asn Ala Ile Asn Ala Gly Ile Thr Phe Ala Leu Ala Ala Gly Asn Ser 
145                 150                 155                 160 


Asn Arg Asp Ala Cys Gln Phe Ser Pro Ala Arg Val Thr Ala Gly Ile 
                165                 170                 175     


Thr Val Gly Ala Thr Thr Ser Thr Asp Ala Arg Ala Ser Tyr Ser Asn 
            180                 185                 190         


Tyr Gly Ser Cys Leu Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser 
        195                 200                 205             


Ala Ser Ile Asp Cys Ser Thr Cys Phe Val Ser Ile Ser Gly Thr Ser 
    210                 215                 220                 


Met Ala Thr Pro His Val Ala Gly Val Ala Ala Leu Tyr Leu Gln Ser 
225                 230                 235                 240 


Asn Pro Ser Ala Ser Pro Ala Thr Val Arg Asn Ala Ile Val Gly Gln 
                245                 250                 255     


Ala Thr Ser Gly Val Val Ser Asn Ala Gly Arg Arg Ser Pro Asn Leu 
            260                 265                 270         


Leu Leu Tyr Ser Asn Tyr Glu Asn Leu Tyr 
        275                 280         


<210>  108
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  108

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu Cys Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  109
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  109

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Cys Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  110
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  110

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Cys Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  111
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  111

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Cys Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  112
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  112

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Cys Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr 
            


<210>  113
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  113

Met Lys Asn Leu Asp Cys Trp Val Asp Asn Glu Glu Asp Ile Asp Val 
1               5                   10                  15      


Ile Leu Lys Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile 
            20                  25                  30          


Ile Ser Asp Ile Ser Gly Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp 
        35                  40                  45              


Ala Gln Leu Val Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn 
    50                  55                  60                  


Asn Glu Ser Ser Glu Val Ile Val His Lys Ala Met Asp Ile Glu Tyr 
65                  70                  75                  80  


Asn Asp Met Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
                85                  90                  95      


Lys Val Ser Ala Ser His Leu Glu Gln Tyr Gly Thr Asn Glu Tyr Ser 
            100                 105                 110         


Ile Ile Ser Ser Met Lys Lys His Ser Leu Ser Ile Gly Ser Gly Trp 
        115                 120                 125             


Ser Val Ser Leu Lys Gly Asn Asn Leu Ile Trp Thr Leu Lys Asp Ser 
    130                 135                 140                 


Ala Gly Glu Val Arg Gln Ile Thr Phe Arg Asp Leu Pro Asp Lys Phe 
145                 150                 155                 160 


Asn Ala Tyr Leu Ala Asn Lys Trp Val Phe Ile Thr Ile Thr Asn Asp 
                165                 170                 175     


Arg Leu Ser Ser Ala Asn Leu Tyr Ile Asn Gly Val Leu Met Gly Ser 
            180                 185                 190         


Ala Glu Ile Thr Gly Leu Gly Ala Ile Arg Glu Asp Asn Asn Ile Thr 
        195                 200                 205             


Leu Lys Leu Asp Arg Cys Asn Asn Asn Asn Gln Tyr Val Ser Ile Asp 
    210                 215                 220                 


Lys Phe Arg Ile Phe Cys Lys Ala Leu Asn Pro Lys Glu Ile Glu Lys 
225                 230                 235                 240 


Leu Tyr Thr Ser Tyr Leu Ser Ile Thr Phe Leu Arg Asp Phe Trp Gly 
                245                 250                 255     


Asn Pro Leu Arg Tyr Asp Thr Glu Tyr Tyr Leu Ile Pro Val Ala Ser 
            260                 265                 270         


Ser Ser Lys Asp Val Gln Leu Lys Asn Ile Thr Asp Tyr Met Tyr Leu 
        275                 280                 285             


Thr Asn Ala Pro Ser Tyr Thr Asn Gly Lys Leu Asn Ile Tyr Tyr Arg 
    290                 295                 300                 


Arg Leu Tyr Asn Gly Leu Lys Phe Ile Ile Lys Arg Tyr Thr Pro Asn 
305                 310                 315                 320 


Asn Glu Ile Asp Ser Phe Val Lys Ser Gly Asp Phe Ile Lys Leu Tyr 
                325                 330                 335     


Val Ser Tyr Asn Asn Asn Glu His Ile Val Gly Tyr Pro Lys Asp Gly 
            340                 345                 350         


Asn Ala Phe Asn Asn Leu Asp Arg Ile Leu Arg Val Gly Tyr Asn Ala 
        355                 360                 365             


Pro Gly Ile Pro Leu Tyr Lys Lys Met Glu Ala Val Lys Leu Arg Asp 
    370                 375                 380                 


Leu Lys Thr Tyr Ser Val Gln Leu Lys Leu Tyr Asp Asp Lys Asn Ala 
385                 390                 395                 400 


Ser Leu Gly Leu Val Gly Thr His Asn Gly Gln Ile Gly Asn Asp Pro 
                405                 410                 415     


Asn Arg Asp Ile Leu Ile Ala Ser Asn Trp Tyr Phe Asn His Leu Lys 
            420                 425                 430         


Asp Lys Ile Leu Gly Cys Asp Trp Tyr Phe Val Pro Thr Asp Glu Gly 
        435                 440                 445             


Trp Thr Asn Asp 
    450         


<210>  114
<211>  1163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  114

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Lys Asn 
            660                 665                 670         


Leu Asp Cys Trp Val Asp Asn Glu Glu Asp Ile Asp Val Ile Leu Lys 
        675                 680                 685             


Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile Ile Ser Asp 
    690                 695                 700                 


Ile Ser Gly Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp Ala Gln Leu 
705                 710                 715                 720 


Val Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn Glu Ser 
                725                 730                 735     


Ser Glu Val Ile Val His Lys Ala Met Asp Ile Glu Tyr Asn Asp Met 
            740                 745                 750         


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
        755                 760                 765             


Ala Ser His Leu Glu Gln Tyr Gly Thr Asn Glu Tyr Ser Ile Ile Ser 
    770                 775                 780                 


Ser Met Lys Lys His Ser Leu Ser Ile Gly Ser Gly Trp Ser Val Ser 
785                 790                 795                 800 


Leu Lys Gly Asn Asn Leu Ile Trp Thr Leu Lys Asp Ser Ala Gly Glu 
                805                 810                 815     


Val Arg Gln Ile Thr Phe Arg Asp Leu Pro Asp Lys Phe Asn Ala Tyr 
            820                 825                 830         


Leu Ala Asn Lys Trp Val Phe Ile Thr Ile Thr Asn Asp Arg Leu Ser 
        835                 840                 845             


Ser Ala Asn Leu Tyr Ile Asn Gly Val Leu Met Gly Ser Ala Glu Ile 
    850                 855                 860                 


Thr Gly Leu Gly Ala Ile Arg Glu Asp Asn Asn Ile Thr Leu Lys Leu 
865                 870                 875                 880 


Asp Arg Cys Asn Asn Asn Asn Gln Tyr Val Ser Ile Asp Lys Phe Arg 
                885                 890                 895     


Ile Phe Cys Lys Ala Leu Asn Pro Lys Glu Ile Glu Lys Leu Tyr Thr 
            900                 905                 910         


Ser Tyr Leu Ser Ile Thr Phe Leu Arg Asp Phe Trp Gly Asn Pro Leu 
        915                 920                 925             


Arg Tyr Asp Thr Glu Tyr Tyr Leu Ile Pro Val Ala Ser Ser Ser Lys 
    930                 935                 940                 


Asp Val Gln Leu Lys Asn Ile Thr Asp Tyr Met Tyr Leu Thr Asn Ala 
945                 950                 955                 960 


Pro Ser Tyr Thr Asn Gly Lys Leu Asn Ile Tyr Tyr Arg Arg Leu Tyr 
                965                 970                 975     


Asn Gly Leu Lys Phe Ile Ile Lys Arg Tyr Thr Pro Asn Asn Glu Ile 
            980                 985                 990         


Asp Ser Phe Val Lys Ser Gly Asp  Phe Ile Lys Leu Tyr  Val Ser Tyr 
        995                 1000                 1005             


Asn Asn  Asn Glu His Ile Val  Gly Tyr Pro Lys Asp  Gly Asn Ala 
    1010                 1015                 1020             


Phe Asn  Asn Leu Asp Arg Ile  Leu Arg Val Gly Tyr  Asn Ala Pro 
    1025                 1030                 1035             


Gly Ile  Pro Leu Tyr Lys Lys  Met Glu Ala Val Lys  Leu Arg Asp 
    1040                 1045                 1050             


Leu Lys  Thr Tyr Ser Val Gln  Leu Lys Leu Tyr Asp  Asp Lys Asn 
    1055                 1060                 1065             


Ala Ser  Leu Gly Leu Val Gly  Thr His Asn Gly Gln  Ile Gly Asn 
    1070                 1075                 1080             


Asp Pro  Asn Arg Asp Ile Leu  Ile Ala Ser Asn Trp  Tyr Phe Asn 
    1085                 1090                 1095             


His Leu  Lys Asp Lys Ile Leu  Gly Cys Asp Trp Tyr  Phe Val Pro 
    1100                 1105                 1110             


Thr Asp  Glu Gly Trp Thr Asn  Asp Gly Gly Gly Leu  Val Pro Gln 
    1115                 1120                 1125             


Gln Ser  Gly Ala His Ile Val  Met Val Asp Ala Tyr  Lys Pro Thr 
    1130                 1135                 1140             


Lys Gly  Ser Gly His His His  His His His Ser Ala  Trp Ser His 
    1145                 1150                 1155             


Pro Gln  Phe Glu Lys 
    1160             


<210>  115
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  115

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Gly Leu Val Pro Gln Gln Ser Gly Ala His Ile 
            660                 665                 670         


Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Ser Gly His His His 
        675                 680                 685             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    690                 695                 700     


<210>  116
<211>  1235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  116

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Ser Gly Gly Met Lys Asn Leu Asp Cys Trp Val 
            660                 665                 670         


Asp Asn Glu Glu Asp Ile Asp Val Ile Leu Lys Lys Ser Thr Ile Leu 
        675                 680                 685             


Asn Leu Asp Ile Asn Asn Asp Ile Ile Ser Asp Ile Ser Gly Phe Asn 
    690                 695                 700                 


Ser Ser Val Ile Thr Tyr Pro Asp Ala Gln Leu Val Pro Gly Ile Asn 
705                 710                 715                 720 


Gly Lys Ala Ile His Leu Val Asn Asn Glu Ser Ser Glu Val Ile Val 
                725                 730                 735     


His Lys Ala Met Asp Ile Glu Tyr Asn Asp Met Phe Asn Asn Phe Thr 
            740                 745                 750         


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
        755                 760                 765             


Gln Tyr Gly Thr Asn Glu Tyr Ser Ile Ile Ser Ser Met Lys Lys His 
    770                 775                 780                 


Ser Leu Ser Ile Gly Ser Gly Trp Ser Val Ser Leu Lys Gly Asn Asn 
785                 790                 795                 800 


Leu Ile Trp Thr Leu Lys Asp Ser Ala Gly Glu Val Arg Gln Ile Thr 
                805                 810                 815     


Phe Arg Asp Leu Pro Asp Lys Phe Asn Ala Tyr Leu Ala Asn Lys Trp 
            820                 825                 830         


Val Phe Ile Thr Ile Thr Asn Asp Arg Leu Ser Ser Ala Asn Leu Tyr 
        835                 840                 845             


Ile Asn Gly Val Leu Met Gly Ser Ala Glu Ile Thr Gly Leu Gly Ala 
    850                 855                 860                 


Ile Arg Glu Asp Asn Asn Ile Thr Leu Lys Leu Asp Arg Cys Asn Asn 
865                 870                 875                 880 


Asn Asn Gln Tyr Val Ser Ile Asp Lys Phe Arg Ile Phe Cys Lys Ala 
                885                 890                 895     


Leu Asn Pro Lys Glu Ile Glu Lys Leu Tyr Thr Ser Tyr Leu Ser Ile 
            900                 905                 910         


Thr Phe Leu Arg Asp Phe Trp Gly Asn Pro Leu Arg Tyr Asp Thr Glu 
        915                 920                 925             


Tyr Tyr Leu Ile Pro Val Ala Ser Ser Ser Lys Asp Val Gln Leu Lys 
    930                 935                 940                 


Asn Ile Thr Asp Tyr Met Tyr Leu Thr Asn Ala Pro Ser Tyr Thr Asn 
945                 950                 955                 960 


Gly Lys Leu Asn Ile Tyr Tyr Arg Arg Leu Tyr Asn Gly Leu Lys Phe 
                965                 970                 975     


Ile Ile Lys Arg Tyr Thr Pro Asn Asn Glu Ile Asp Ser Phe Val Lys 
            980                 985                 990         


Ser Gly Asp Phe Ile Lys Leu Tyr  Val Ser Tyr Asn Asn  Asn Glu His 
        995                 1000                 1005             


Ile Val  Gly Tyr Pro Lys Asp  Gly Asn Ala Phe Asn  Asn Leu Asp 
    1010                 1015                 1020             


Arg Ile  Leu Arg Val Gly Tyr  Asn Ala Pro Gly Ile  Pro Leu Tyr 
    1025                 1030                 1035             


Lys Lys  Met Glu Ala Val Lys  Leu Arg Asp Leu Lys  Thr Tyr Ser 
    1040                 1045                 1050             


Val Gln  Leu Lys Leu Tyr Asp  Asp Lys Asn Ala Ser  Leu Gly Leu 
    1055                 1060                 1065             


Val Gly  Thr His Asn Gly Gln  Ile Gly Asn Asp Pro  Asn Arg Asp 
    1070                 1075                 1080             


Ile Leu  Ile Ala Ser Asn Trp  Tyr Phe Asn His Leu  Lys Asp Lys 
    1085                 1090                 1095             


Ile Leu  Gly Cys Asp Trp Tyr  Phe Val Pro Thr Asp  Glu Gly Trp 
    1100                 1105                 1110             


Thr Asn  Asp Gly Ser Gly Asp  Ser Ala Thr His Ile  Lys Phe Ser 
    1115                 1120                 1125             


Lys Arg  Asp Glu Asp Gly Lys  Glu Leu Ala Gly Ala  Thr Met Glu 
    1130                 1135                 1140             


Leu Arg  Asp Ser Ser Gly Lys  Thr Ile Ser Thr Trp  Ile Ser Asp 
    1145                 1150                 1155             


Gly Gln  Val Lys Asp Phe Tyr  Leu Tyr Pro Gly Lys  Tyr Thr Phe 
    1160                 1165                 1170             


Val Glu  Thr Ala Ala Pro Asp  Gly Tyr Glu Val Ala  Thr Ala Ile 
    1175                 1180                 1185             


Thr Phe  Thr Val Asn Glu Gln  Gly Gln Val Thr Val  Asn Gly Lys 
    1190                 1195                 1200             


Ala Thr  Lys Gly Asp Ala His  Ile Gly Gly Leu Val  Pro Arg Gly 
    1205                 1210                 1215             


Ser His  His His His His His  Ser Ala Trp Ser His  Pro Gln Phe 
    1220                 1225                 1230             


Glu Lys  
    1235 


<210>  117
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  117

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Val Pro Arg Gly Ser His His His His His His 
        755                 760                 765             


Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775             


<210>  118
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  118

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Gly Gly Gly Ser Gly Asp Ser Ala Thr His Ile Lys 
            660                 665                 670         


Phe Ser Lys Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met 
        675                 680                 685             


Glu Leu Arg Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp 
    690                 695                 700                 


Gly Gln Val Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val 
705                 710                 715                 720 


Glu Thr Ala Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe 
                725                 730                 735     


Thr Val Asn Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys 
            740                 745                 750         


Gly Asp Ala His Ile Gly Gly Leu Val Pro Arg Gly Ser His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  119
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  119

Met Glu Phe Leu Lys Arg Ser Phe Ala Pro Leu Thr Glu Lys Gln Trp 
1               5                   10                  15      


Gln Glu Ile Asp Asn Arg Ala Arg Glu Ile Phe Lys Thr Gln Leu Tyr 
            20                  25                  30          


Gly Arg Lys Phe Val Asp Val Glu Gly Pro Tyr Gly Trp Glu Tyr Ala 
        35                  40                  45              


Ala His Pro Leu Cys Glu Val Glu Val Leu Ser Asp Glu Asn Glu Val 
    50                  55                  60                  


Val Lys Trp Gly Leu Arg Lys Ser Leu Pro Leu Ile Glu Leu Arg Ala 
65                  70                  75                  80  


Thr Phe Thr Leu Asp Leu Trp Glu Leu Asp Asn Leu Glu Cys Gly Lys 
                85                  90                  95      


Pro Asn Val Asp Leu Ser Ser Leu Glu Glu Thr Val Arg Lys Val Ala 
            100                 105                 110         


Glu Phe Glu Asp Glu Val Ile Phe Arg Gly Cys Glu Lys Ser Gly Val 
        115                 120                 125             


Lys Gly Leu Leu Ser Phe Glu Glu Arg Lys Ile Glu Cys Gly Ser Thr 
    130                 135                 140                 


Pro Lys Asp Leu Leu Glu Ala Ile Val Arg Ala Leu Ser Ile Phe Ser 
145                 150                 155                 160 


Lys Asp Gly Ile Glu Gly Pro Tyr Thr Leu Val Ile Asn Thr Asp Arg 
                165                 170                 175     


Trp Ile Asn Phe Leu Lys Glu Glu Ala Gly His Tyr Pro Leu Glu Lys 
            180                 185                 190         


Arg Val Glu Glu Cys Leu Arg Gly Gly Lys Ile Ile Thr Thr Pro Arg 
        195                 200                 205             


Ile Glu Asp Ala Leu Val Val Ser Glu Arg Gly Gly Asp Phe Lys Leu 
    210                 215                 220                 


Ile Leu Gly Gln Asp Leu Ser Ile Gly Tyr Glu Asp Arg Glu Lys Asp 
225                 230                 235                 240 


Ala Val Arg Leu Phe Ile Thr Glu Thr Phe Thr Phe Gln Val Val Asn 
                245                 250                 255     


Pro Glu Ala Leu Ile Leu Leu Lys Phe Gly Ser Gly Ser Gly Ser Val 
            260                 265                 270         


Pro Thr Ile Val Met Val Asp Ala Tyr Lys Arg Tyr Lys 
        275                 280                 285 


<210>  120
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  120

Met Glu Phe Leu Lys Arg Ser Phe Ala Pro Leu Thr Glu Lys Gln Trp 
1               5                   10                  15      


Gln Glu Ile Asp Asn Arg Ala Arg Glu Ile Phe Lys Thr Gln Leu Tyr 
            20                  25                  30          


Gly Arg Lys Phe Val Asp Val Glu Gly Pro Tyr Gly Trp Glu Tyr Ala 
        35                  40                  45              


Ala His Pro Leu Cys Glu Val Glu Val Leu Ser Asp Glu Asn Glu Val 
    50                  55                  60                  


Val Lys Trp Gly Leu Arg Lys Ser Leu Pro Leu Ile Glu Leu Arg Ala 
65                  70                  75                  80  


Thr Phe Thr Leu Asp Leu Trp Glu Leu Asp Asn Leu Glu Cys Gly Lys 
                85                  90                  95      


Pro Asn Val Asp Leu Ser Ser Leu Glu Glu Thr Val Arg Lys Val Ala 
            100                 105                 110         


Glu Phe Glu Asp Glu Val Ile Phe Arg Gly Cys Glu Lys Ser Gly Val 
        115                 120                 125             


Lys Gly Leu Leu Ser Phe Glu Glu Arg Lys Ile Glu Cys Gly Ser Thr 
    130                 135                 140                 


Pro Lys Asp Leu Leu Glu Ala Ile Val Arg Ala Leu Ser Ile Phe Ser 
145                 150                 155                 160 


Lys Asp Gly Ile Glu Gly Pro Tyr Thr Leu Val Ile Asn Thr Asp Arg 
                165                 170                 175     


Trp Ile Asn Phe Leu Lys Glu Glu Ala Gly His Tyr Pro Leu Glu Lys 
            180                 185                 190         


Arg Val Glu Glu Cys Leu Arg Gly Gly Lys Ile Ile Thr Thr Pro Arg 
        195                 200                 205             


Ile Glu Asp Ala Leu Val Val Ser Glu Arg Gly Gly Asp Phe Lys Leu 
    210                 215                 220                 


Ile Leu Gly Gln Asp Leu Ser Ile Gly Tyr Glu Asp Arg Glu Lys Asp 
225                 230                 235                 240 


Ala Val Arg Leu Phe Ile Thr Glu Thr Phe Thr Phe Gln Val Val Asn 
                245                 250                 255     


Pro Glu Ala Leu Ile Leu Leu Lys Phe Gly Ser Gly Ser Gly Ser Val 
            260                 265                 270         


Thr Thr Leu Ser Gly Leu Ser Gly Glu Gln Gly Pro Ser Gly Asp Met 
        275                 280                 285             


Thr Thr Glu Glu Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg Asp 
    290                 295                 300                 


Glu Asp Gly Arg Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser 
305                 310                 315                 320 


Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly His Val Lys Asp 
                325                 330                 335     


Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala Pro 
            340                 345                 350         


Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu Gln 
        355                 360                 365             


Gly Gln Val Thr Val Asn Gly Glu Ala Thr Lys Gly Asp Ala His Thr 
    370                 375                 380                 


Gly Ser Ser Gly Ser 
385                 


<210>  121
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  121

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Val Gly Ala His 
            20                  25                  30          


Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Ser Gly Ser Ala 
        35                  40                  45              


Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
    50                  55                  60                  


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
65                  70                  75                  80  


Gly Ala Ile Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
                85                  90                  95      


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
            100                 105                 110         


Glu Leu Ala Arg Lys Glu Asn Ile Ser Ala Val Ile Ala Ile Gly Val 
        115                 120                 125             


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
    130                 135                 140                 


Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
145                 150                 155                 160 


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
                165                 170                 175     


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
            180                 185                 190         


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg Gly Gly Leu Val Pro Arg 
        195                 200                 205             


Gly Ser His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
    210                 215                 220                 


Glu Lys 
225     


<210>  122
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  122

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Val Gly Gln His 
            20                  25                  30          


His His His His His His His Ser Ala Trp Ser His Pro Gln Phe Glu 
        35                  40                  45              


Lys Gly Gly Leu Val Pro Arg Gly Gly Ala His Ile Val Met Val Asp 
    50                  55                  60                  


Ala Tyr Lys Pro Thr Lys Gly Gly Gly Ser Gly Asp Pro Met Leu Ser 
65                  70                  75                  80  


Lys Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln 
                85                  90                  95      


Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser 
            100                 105                 110         


Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr 
        115                 120                 125             


Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro 
    130                 135                 140                 


Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu 
145                 150                 155                 160 


Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln Asn Ile Ser Glu 
                165                 170                 175     


Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala 
            180                 185                 190         


Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu 
        195                 200                 205             


Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu 
    210                 215                 220                 


Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys 
225                 230                 235                 240 


Ser Arg Lys Ser 
                


<210>  123
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  123

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  124
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  124

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro Lys 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Gln Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ser Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Ile Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Val Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Thr Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  125
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  125

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Asn 
    50                  55                  60                  


Asp Thr His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  126
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  126

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly Asn Ala Thr His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  127
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  127

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Asn Asn Ser Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  128
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  128

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Asn Asp Ser 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  129
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  129

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Asn Thr Thr Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  130
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  130

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Asn Lys Ser Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  131
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  131

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asn Ser Thr Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  132
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  132

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Asn Gly Thr Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  133
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  133

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Ser Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  134
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  134

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg 
    50                  55                  60                  


Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Asn Val Ser Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  135
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  135

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Gln 
1               5                   10                  15      


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly 
            20                  25                  30          


Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu 
        35                  40                  45              


Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys 
    50                  55                  60                  


Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg 
65                  70                  75                  80  


Glu Gly Thr Asn Asp Thr His Val Gln Arg Thr Val Ser Thr Leu Arg 
                85                  90                  95      


Ala Gln Ala Ala Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr 
            100                 105                 110         


Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu 
        115                 120                 125             


Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser 
    130                 135                 140                 


Ser Ile Phe Ala Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
145                 150                 155                 160 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln 
                165                 170                 175     


Val Thr Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu 
            180                 185                 190         


Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu 
        195                 200                 205             


Asp Gly Thr Arg Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly 
    210                 215                 220                 


Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg 
225                 230                 235                 240 


Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly 
                245                 250                 255     


Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu 
            260                 265                 270         


Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly 
        275                 280                 285             


Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser 
    290                 295                 300                 


Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys 
305                 310                 315                 320 


Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser 
                325                 330                 335     


Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu 
            340                 345                 350         


Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        355                 360                 365             


Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln 
    370                 375                 380                 


Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr 
385                 390                 395                 400 


Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala 
                405                 410                 415     


Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu 
            420                 425                 430         


Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly 
        435                 440                 445             


Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly 
    450                 455                 460                 


Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe 
465                 470                 475                 480 


Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile 
                485                 490                 495     


Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly 
            500                 505                 510         


Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val 
        515                 520                 525             


Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys 
    530                 535                 540                 


Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg 
545                 550                 555                 560 


Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys 
                565                 570                 575     


Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His 
            580                 585                 590         


Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe 
        595                 600                 605             


Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly 
    610                 615                 620                 


Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg 
625                 630                 635                 640 


Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala 
                645                 650                 655     


Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn 
            660                 665                 670         


Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly 
        675                 680                 685             


Pro Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
    690                 695                 700                 


Glu Lys 
705     


<210>  136
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  136

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Gln 
1               5                   10                  15      


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly 
            20                  25                  30          


Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu 
        35                  40                  45              


Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys 
    50                  55                  60                  


Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg 
65                  70                  75                  80  


Glu Gly Thr Arg Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg 
                85                  90                  95      


Ala Gln Ala Ala Arg Arg Gly Asn Ala Thr His Ile Met His Thr Tyr 
            100                 105                 110         


Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu 
        115                 120                 125             


Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser 
    130                 135                 140                 


Ser Ile Phe Ala Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
145                 150                 155                 160 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln 
                165                 170                 175     


Val Thr Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu 
            180                 185                 190         


Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu 
        195                 200                 205             


Asp Gly Thr Arg Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly 
    210                 215                 220                 


Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg 
225                 230                 235                 240 


Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly 
                245                 250                 255     


Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu 
            260                 265                 270         


Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly 
        275                 280                 285             


Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser 
    290                 295                 300                 


Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys 
305                 310                 315                 320 


Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser 
                325                 330                 335     


Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu 
            340                 345                 350         


Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        355                 360                 365             


Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln 
    370                 375                 380                 


Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr 
385                 390                 395                 400 


Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala 
                405                 410                 415     


Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu 
            420                 425                 430         


Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly 
        435                 440                 445             


Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly 
    450                 455                 460                 


Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe 
465                 470                 475                 480 


Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile 
                485                 490                 495     


Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly 
            500                 505                 510         


Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val 
        515                 520                 525             


Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys 
    530                 535                 540                 


Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg 
545                 550                 555                 560 


Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys 
                565                 570                 575     


Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His 
            580                 585                 590         


Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe 
        595                 600                 605             


Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly 
    610                 615                 620                 


Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg 
625                 630                 635                 640 


Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala 
                645                 650                 655     


Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn 
            660                 665                 670         


Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly 
        675                 680                 685             


Pro Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
    690                 695                 700                 


Glu Lys 
705     


<210>  137
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  137

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Gln 
1               5                   10                  15      


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly 
            20                  25                  30          


Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu 
        35                  40                  45              


Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys 
    50                  55                  60                  


Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg 
65                  70                  75                  80  


Glu Gly Thr Arg Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg 
                85                  90                  95      


Ala Gln Ala Ala Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr 
            100                 105                 110         


Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu 
        115                 120                 125             


Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser 
    130                 135                 140                 


Ser Ile Phe Ala Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
145                 150                 155                 160 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln 
                165                 170                 175     


Val Thr Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu 
            180                 185                 190         


Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu 
        195                 200                 205             


Asp Gly Thr Arg Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly 
    210                 215                 220                 


Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg 
225                 230                 235                 240 


Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly 
                245                 250                 255     


Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu 
            260                 265                 270         


Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly 
        275                 280                 285             


Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser 
    290                 295                 300                 


Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys 
305                 310                 315                 320 


Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser 
                325                 330                 335     


Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu 
            340                 345                 350         


Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        355                 360                 365             


Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln 
    370                 375                 380                 


Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr 
385                 390                 395                 400 


Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala 
                405                 410                 415     


Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu 
            420                 425                 430         


Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly 
        435                 440                 445             


Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly 
    450                 455                 460                 


Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe 
465                 470                 475                 480 


Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile 
                485                 490                 495     


Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly 
            500                 505                 510         


Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val 
        515                 520                 525             


Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys 
    530                 535                 540                 


Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg 
545                 550                 555                 560 


Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Asn Asn Ser Lys 
                565                 570                 575     


Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His 
            580                 585                 590         


Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe 
        595                 600                 605             


Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly 
    610                 615                 620                 


Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg 
625                 630                 635                 640 


Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala 
                645                 650                 655     


Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn 
            660                 665                 670         


Asn Asn His Glu Gln Asn Gly Gly Leu Glu Val Leu Phe Gln Gly Pro 
        675                 680                 685             


Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe Glu 
    690                 695                 700                 


Lys 
705 


<210>  138
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  138

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Gln 
1               5                   10                  15      


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly 
            20                  25                  30          


Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu 
        35                  40                  45              


Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys 
    50                  55                  60                  


Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg 
65                  70                  75                  80  


Glu Gly Thr Arg Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg 
                85                  90                  95      


Ala Gln Ala Ala Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr 
            100                 105                 110         


Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu 
        115                 120                 125             


Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser 
    130                 135                 140                 


Ser Ile Phe Ala Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
145                 150                 155                 160 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln 
                165                 170                 175     


Val Thr Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu 
            180                 185                 190         


Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu 
        195                 200                 205             


Asp Gly Thr Arg Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly 
    210                 215                 220                 


Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg 
225                 230                 235                 240 


Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly 
                245                 250                 255     


Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu 
            260                 265                 270         


Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly 
        275                 280                 285             


Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser 
    290                 295                 300                 


Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys 
305                 310                 315                 320 


Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser 
                325                 330                 335     


Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu 
            340                 345                 350         


Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        355                 360                 365             


Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln 
    370                 375                 380                 


Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr 
385                 390                 395                 400 


Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala 
                405                 410                 415     


Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu 
            420                 425                 430         


Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly 
        435                 440                 445             


Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly 
    450                 455                 460                 


Ser Asn Asp Ser Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe 
465                 470                 475                 480 


Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile 
                485                 490                 495     


Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly 
            500                 505                 510         


Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val 
        515                 520                 525             


Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys 
    530                 535                 540                 


Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg 
545                 550                 555                 560 


Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys 
                565                 570                 575     


Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His 
            580                 585                 590         


Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe 
        595                 600                 605             


Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly 
    610                 615                 620                 


Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg 
625                 630                 635                 640 


Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala 
                645                 650                 655     


Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn 
            660                 665                 670         


Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly 
        675                 680                 685             


Pro Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
    690                 695                 700                 


Glu Lys 
705     


<210>  139
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  139

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Gln 
1               5                   10                  15      


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly 
            20                  25                  30          


Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu 
        35                  40                  45              


Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys 
    50                  55                  60                  


Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg 
65                  70                  75                  80  


Glu Gly Thr Arg Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg 
                85                  90                  95      


Ala Gln Ala Ala Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr 
            100                 105                 110         


Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu 
        115                 120                 125             


Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser 
    130                 135                 140                 


Ser Ile Phe Ala Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
145                 150                 155                 160 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln 
                165                 170                 175     


Val Thr Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu 
            180                 185                 190         


Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu 
        195                 200                 205             


Asp Gly Thr Arg Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly 
    210                 215                 220                 


Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg 
225                 230                 235                 240 


Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly 
                245                 250                 255     


Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu 
            260                 265                 270         


Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly 
        275                 280                 285             


Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser 
    290                 295                 300                 


Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys 
305                 310                 315                 320 


Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser 
                325                 330                 335     


Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu 
            340                 345                 350         


Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        355                 360                 365             


Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln 
    370                 375                 380                 


Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr 
385                 390                 395                 400 


Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala 
                405                 410                 415     


Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu 
            420                 425                 430         


Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly 
        435                 440                 445             


Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly 
    450                 455                 460                 


Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe 
465                 470                 475                 480 


Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile 
                485                 490                 495     


Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly 
            500                 505                 510         


Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val 
        515                 520                 525             


Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys 
    530                 535                 540                 


Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg 
545                 550                 555                 560 


Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys 
                565                 570                 575     


Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His 
            580                 585                 590         


Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Asn 
        595                 600                 605             


Thr Thr Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly 
    610                 615                 620                 


Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg 
625                 630                 635                 640 


Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala 
                645                 650                 655     


Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn 
            660                 665                 670         


Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly 
        675                 680                 685             


Pro Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
    690                 695                 700                 


Glu Lys 
705     


<210>  140
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  140

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Gln 
1               5                   10                  15      


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly 
            20                  25                  30          


Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu 
        35                  40                  45              


Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys 
    50                  55                  60                  


Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg 
65                  70                  75                  80  


Glu Gly Thr Arg Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg 
                85                  90                  95      


Ala Gln Ala Ala Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr 
            100                 105                 110         


Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu 
        115                 120                 125             


Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser 
    130                 135                 140                 


Ser Ile Phe Ala Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
145                 150                 155                 160 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln 
                165                 170                 175     


Val Thr Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu 
            180                 185                 190         


Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu 
        195                 200                 205             


Asp Gly Thr Arg Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly 
    210                 215                 220                 


Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg 
225                 230                 235                 240 


Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly 
                245                 250                 255     


Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu 
            260                 265                 270         


Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly 
        275                 280                 285             


Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser 
    290                 295                 300                 


Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys 
305                 310                 315                 320 


Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser 
                325                 330                 335     


Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu 
            340                 345                 350         


Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        355                 360                 365             


Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln 
    370                 375                 380                 


Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr 
385                 390                 395                 400 


Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala 
                405                 410                 415     


Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu 
            420                 425                 430         


Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly 
        435                 440                 445             


Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly 
    450                 455                 460                 


Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe 
465                 470                 475                 480 


Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile 
                485                 490                 495     


Glu Ile Arg Asp Gly Asn Lys Ser Cys Glu Ala His His Gly Ile Gly 
            500                 505                 510         


Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val 
        515                 520                 525             


Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys 
    530                 535                 540                 


Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg 
545                 550                 555                 560 


Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys 
                565                 570                 575     


Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His 
            580                 585                 590         


Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe 
        595                 600                 605             


Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly 
    610                 615                 620                 


Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg 
625                 630                 635                 640 


Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala 
                645                 650                 655     


Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn 
            660                 665                 670         


Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly 
        675                 680                 685             


Pro Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
    690                 695                 700                 


Glu Lys 
705     


<210>  141
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  141

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Gln 
1               5                   10                  15      


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly 
            20                  25                  30          


Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu 
        35                  40                  45              


Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys 
    50                  55                  60                  


Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg 
65                  70                  75                  80  


Glu Gly Thr Arg Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg 
                85                  90                  95      


Ala Gln Ala Ala Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr 
            100                 105                 110         


Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu 
        115                 120                 125             


Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser 
    130                 135                 140                 


Ser Ile Phe Ala Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
145                 150                 155                 160 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln 
                165                 170                 175     


Val Thr Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu 
            180                 185                 190         


Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu 
        195                 200                 205             


Asp Gly Thr Arg Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly 
    210                 215                 220                 


Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg 
225                 230                 235                 240 


Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly 
                245                 250                 255     


Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu 
            260                 265                 270         


Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly 
        275                 280                 285             


Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser 
    290                 295                 300                 


Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys 
305                 310                 315                 320 


Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser 
                325                 330                 335     


Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu 
            340                 345                 350         


Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        355                 360                 365             


Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln 
    370                 375                 380                 


Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr 
385                 390                 395                 400 


Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala 
                405                 410                 415     


Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu 
            420                 425                 430         


Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly 
        435                 440                 445             


Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly 
    450                 455                 460                 


Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe 
465                 470                 475                 480 


Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile 
                485                 490                 495     


Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly 
            500                 505                 510         


Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val 
        515                 520                 525             


Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys 
    530                 535                 540                 


Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg 
545                 550                 555                 560 


Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys 
                565                 570                 575     


Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His 
            580                 585                 590         


Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe 
        595                 600                 605             


Thr Lys Gln Val Glu Val Ser Cys Glu Asn Ser Thr Thr Leu Thr Gly 
    610                 615                 620                 


Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg 
625                 630                 635                 640 


Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala 
                645                 650                 655     


Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn 
            660                 665                 670         


Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly 
        675                 680                 685             


Pro Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
    690                 695                 700                 


Glu Lys 
705     


<210>  142
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  142

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Gln 
1               5                   10                  15      


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly 
            20                  25                  30          


Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu 
        35                  40                  45              


Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys 
    50                  55                  60                  


Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg 
65                  70                  75                  80  


Glu Gly Thr Arg Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg 
                85                  90                  95      


Ala Gln Ala Ala Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr 
            100                 105                 110         


Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu 
        115                 120                 125             


Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser 
    130                 135                 140                 


Ser Ile Phe Ala Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
145                 150                 155                 160 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln 
                165                 170                 175     


Val Thr Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu 
            180                 185                 190         


Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu 
        195                 200                 205             


Asp Gly Thr Arg Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly 
    210                 215                 220                 


Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg 
225                 230                 235                 240 


Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly 
                245                 250                 255     


Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu 
            260                 265                 270         


Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly 
        275                 280                 285             


Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser 
    290                 295                 300                 


Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys 
305                 310                 315                 320 


Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser 
                325                 330                 335     


Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu 
            340                 345                 350         


Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        355                 360                 365             


Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln 
    370                 375                 380                 


Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr 
385                 390                 395                 400 


Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala 
                405                 410                 415     


Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu 
            420                 425                 430         


Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Asn Gly 
        435                 440                 445             


Thr Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly 
    450                 455                 460                 


Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe 
465                 470                 475                 480 


Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile 
                485                 490                 495     


Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly 
            500                 505                 510         


Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val 
        515                 520                 525             


Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys 
    530                 535                 540                 


Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg 
545                 550                 555                 560 


Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys 
                565                 570                 575     


Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His 
            580                 585                 590         


Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe 
        595                 600                 605             


Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly 
    610                 615                 620                 


Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg 
625                 630                 635                 640 


Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala 
                645                 650                 655     


Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn 
            660                 665                 670         


Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly 
        675                 680                 685             


Pro Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
    690                 695                 700                 


Glu Lys 
705     


<210>  143
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  143

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Gln 
1               5                   10                  15      


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly 
            20                  25                  30          


Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu 
        35                  40                  45              


Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys 
    50                  55                  60                  


Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg 
65                  70                  75                  80  


Glu Gly Thr Arg Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg 
                85                  90                  95      


Ala Gln Ala Ala Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr 
            100                 105                 110         


Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu 
        115                 120                 125             


Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser 
    130                 135                 140                 


Ser Ile Phe Ala Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
145                 150                 155                 160 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln 
                165                 170                 175     


Val Thr Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu 
            180                 185                 190         


Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Ser Pro Lys Glu 
        195                 200                 205             


Asp Gly Thr Arg Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly 
    210                 215                 220                 


Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg 
225                 230                 235                 240 


Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly 
                245                 250                 255     


Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu 
            260                 265                 270         


Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly 
        275                 280                 285             


Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser 
    290                 295                 300                 


Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys 
305                 310                 315                 320 


Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser 
                325                 330                 335     


Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu 
            340                 345                 350         


Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        355                 360                 365             


Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln 
    370                 375                 380                 


Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr 
385                 390                 395                 400 


Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala 
                405                 410                 415     


Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu 
            420                 425                 430         


Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly 
        435                 440                 445             


Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly 
    450                 455                 460                 


Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe 
465                 470                 475                 480 


Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile 
                485                 490                 495     


Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly 
            500                 505                 510         


Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val 
        515                 520                 525             


Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys 
    530                 535                 540                 


Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg 
545                 550                 555                 560 


Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys 
                565                 570                 575     


Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His 
            580                 585                 590         


Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe 
        595                 600                 605             


Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly 
    610                 615                 620                 


Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg 
625                 630                 635                 640 


Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala 
                645                 650                 655     


Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn 
            660                 665                 670         


Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly 
        675                 680                 685             


Pro Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
    690                 695                 700                 


Glu Lys 
705     


<210>  144
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  144

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Gln 
1               5                   10                  15      


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly 
            20                  25                  30          


Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu 
        35                  40                  45              


Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys 
    50                  55                  60                  


Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg 
65                  70                  75                  80  


Glu Gly Thr Arg Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg 
                85                  90                  95      


Ala Gln Ala Ala Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr 
            100                 105                 110         


Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu 
        115                 120                 125             


Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser 
    130                 135                 140                 


Ser Ile Phe Ala Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
145                 150                 155                 160 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Asn 
                165                 170                 175     


Val Ser Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu 
            180                 185                 190         


Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu 
        195                 200                 205             


Asp Gly Thr Arg Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly 
    210                 215                 220                 


Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg 
225                 230                 235                 240 


Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly 
                245                 250                 255     


Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu 
            260                 265                 270         


Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly 
        275                 280                 285             


Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser 
    290                 295                 300                 


Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys 
305                 310                 315                 320 


Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser 
                325                 330                 335     


Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu 
            340                 345                 350         


Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        355                 360                 365             


Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln 
    370                 375                 380                 


Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr 
385                 390                 395                 400 


Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala 
                405                 410                 415     


Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu 
            420                 425                 430         


Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly 
        435                 440                 445             


Glu Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly 
    450                 455                 460                 


Ser Phe Asp Thr Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe 
465                 470                 475                 480 


Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile 
                485                 490                 495     


Glu Ile Arg Asp Gly Gln Lys Val Cys Glu Ala His His Gly Ile Gly 
            500                 505                 510         


Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val 
        515                 520                 525             


Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys 
    530                 535                 540                 


Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg 
545                 550                 555                 560 


Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys 
                565                 570                 575     


Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His 
            580                 585                 590         


Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Phe 
        595                 600                 605             


Thr Lys Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly 
    610                 615                 620                 


Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg 
625                 630                 635                 640 


Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala 
                645                 650                 655     


Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn 
            660                 665                 670         


Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly 
        675                 680                 685             


Pro Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
    690                 695                 700                 


Glu Lys 
705     


<210>  145
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  145

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Asp 
1               5                   10                  15      


Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp 
            20                  25                  30          


Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val 
        35                  40                  45              


Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Asn 
    50                  55                  60                  


Asp Thr His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala 
65                  70                  75                  80  


Arg Arg Gly Asn Ala Thr His Ile Met His Thr Tyr Ser Gly Val Phe 
                85                  90                  95      


His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu 
            100                 105                 110         


Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala 
        115                 120                 125             


Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu 
    130                 135                 140                 


Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Asn Val Ser Val Phe 
145                 150                 155                 160 


Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys 
                165                 170                 175     


Val Met Val Thr Asp Phe Asn Ser Ser Pro Lys Glu Asp Gly Thr Arg 
            180                 185                 190         


Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala 
        195                 200                 205             


Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val 
    210                 215                 220                 


Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro 
                245                 250                 255     


Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg 
            260                 265                 270         


Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu 
        275                 280                 285             


Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro 
    290                 295                 300                 


Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp 
305                 310                 315                 320 


Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val 
                325                 330                 335     


Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys 
            340                 345                 350         


Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His 
        355                 360                 365             


Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser 
    370                 375                 380                 


Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val 
385                 390                 395                 400 


Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp 
                405                 410                 415     


Met Val Ala Ala Leu Pro Thr Ser Ala Ala Asn Gly Thr Lys Leu Leu 
            420                 425                 430         


Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Asn Asp Ser 
        435                 440                 445             


Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser 
    450                 455                 460                 


Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp 
465                 470                 475                 480 


Gly Asn Lys Ser Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val 
                485                 490                 495     


Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala 
            500                 505                 510         


Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu 
        515                 520                 525             


Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val 
    530                 535                 540                 


Ala Gln Pro Ser Trp Pro Leu His Asn Asn Ser Lys Ala Cys Pro Ala 
545                 550                 555                 560 


Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu 
                565                 570                 575     


Glu Cys His Leu Ile Glu His His Gln Ser Glu Asn Thr Thr Gln Val 
            580                 585                 590         


Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val 
        595                 600                 605             


Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys 
    610                 615                 620                 


Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile 
625                 630                 635                 640 


Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu 
                645                 650                 655     


Gln Asn Thr Gly Ser Gly Asp Ser Ala Thr His Ile Lys Phe Ser Lys 
            660                 665                 670         


Arg Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg 
        675                 680                 685             


Asp Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val 
    690                 695                 700                 


Lys Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala 
705                 710                 715                 720 


Ala Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn 
                725                 730                 735     


Glu Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala 
            740                 745                 750         


His Ile Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
        755                 760                 765             


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    770                 775                 780     


<210>  146
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  146

Met His Leu Val Leu Val Leu Cys Leu Ala Ala Leu Ala Ala Cys Gln 
1               5                   10                  15      


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Gly 
            20                  25                  30          


Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln Leu 
        35                  40                  45              


Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys 
    50                  55                  60                  


Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg 
65                  70                  75                  80  


Glu Gly Thr Asn Asp Thr His Val Gln Arg Thr Val Ser Thr Leu Arg 
                85                  90                  95      


Ala Gln Ala Ala Arg Arg Gly Asn Ala Thr His Ile Met His Thr Tyr 
            100                 105                 110         


Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu 
        115                 120                 125             


Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser 
    130                 135                 140                 


Ser Ile Phe Ala Gln Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln 
145                 150                 155                 160 


Thr Lys His Glu Thr Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Asn 
                165                 170                 175     


Val Ser Val Phe Leu Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu 
            180                 185                 190         


Ile Glu Gly Lys Val Met Val Thr Asp Phe Asn Ser Ser Pro Lys Glu 
        195                 200                 205             


Asp Gly Thr Arg Phe His Glu Ser Ala Ser Lys Cys Glu Ser His Gly 
    210                 215                 220                 


Thr His Ile Ala Gly Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg 
225                 230                 235                 240 


Gly Val Ser Val Asn Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly 
                245                 250                 255     


Thr Val Ser Gly Ala Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu 
            260                 265                 270         


Gln Ala Gln Pro Val Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly 
        275                 280                 285             


Gly Phe Ser Arg Thr Leu Asn Thr Ala Cys Arg Glu Met Val His Ser 
    290                 295                 300                 


Gly Ala Val Leu Ile Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys 
305                 310                 315                 320 


Met Tyr Ser Pro Ala Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser 
                325                 330                 335     


Asn Ala Ala Asp Arg Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu 
            340                 345                 350         


Gly Arg Cys Val Asp Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala 
        355                 360                 365             


Ser Gly Asp Cys Ser Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln 
    370                 375                 380                 


Ser Ala Ala His Ala Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr 
385                 390                 395                 400 


Pro Ser Ala Ser Pro Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala 
                405                 410                 415     


Val Gln Arg Val Ile Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu 
            420                 425                 430         


Thr Thr Pro Asp Met Val Ala Ala Leu Pro Thr Ser Ala Ala Asn Gly 
        435                 440                 445             


Thr Lys Leu Leu Cys Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly 
    450                 455                 460                 


Ser Asn Asp Ser Ala Val Ala Arg Cys Arg His Gly Glu Glu Met Phe 
465                 470                 475                 480 


Ser Cys Ser Ser Tyr Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile 
                485                 490                 495     


Glu Ile Arg Asp Gly Asn Lys Ser Cys Glu Ala His His Gly Ile Gly 
            500                 505                 510         


Gly Gln Gly Val Tyr Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val 
        515                 520                 525             


Lys Cys His Ala Ser Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys 
    530                 535                 540                 


Pro Ser Gln Glu Phe Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg 
545                 550                 555                 560 


Ser Gln Asp Val Ala Gln Pro Ser Trp Pro Leu His Asn Asn Ser Lys 
                565                 570                 575     


Ala Cys Pro Ala Gly Glu Gly Gly Thr Ser His Ala Phe Cys Cys His 
            580                 585                 590         


Ala Pro Asn Leu Glu Cys His Leu Ile Glu His His Gln Ser Glu Asn 
        595                 600                 605             


Thr Thr Gln Val Glu Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly 
    610                 615                 620                 


Cys Asn Ala Val Ser His Gly Ser Val Thr His Ala Ala Tyr Thr Arg 
625                 630                 635                 640 


Gly Asn Thr Cys Val Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala 
                645                 650                 655     


Ala Ile Ala Ile Cys Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn 
            660                 665                 670         


Asn Asn His Glu Gln Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly 
        675                 680                 685             


Pro Gly His His His His His His Ser Ala Trp Ser His Pro Gln Phe 
    690                 695                 700                 


Glu Lys 
705     


<210>  147
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  147

Lys Glu Asp Gly Thr Arg Phe His Arg Ser Ala Ser Lys Cys Glu Ser 
1               5                   10                  15      


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  148

Arg Asp Ala Gly Val Ala Arg 
1               5           


<210>  149
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  149

Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr Cys Phe Val Ser 
1               5                   10                  15  


<210>  150
<211>  2064
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  150
atgcatctgg tgctggtgct gtgtctggct gccctggccg cctgtgatta cagcgaggac       60

aaagaagtga aggcccctca gctggatcac cccgatcctg gaacagagag agtggccgag      120

ctgctgagat gcaccaagag cgtttggaga atccccgagc agtacctggt ggtgctgaga      180

gagggcacca gagatagcca cgtgcagaga accgtgtcta ccctgagagc ccaggccgct      240

agaagaggac acgccatcca catcatgcac acctacagcg gcgtgttcca cggctttctg      300

atcaagatga gcagcgaggt gctgcccatg gctctgaaac tgcctcacgt ggcctacatc      360

gaagaggact cctctatctt cgcccagagc atcccctgga acctgcagag aatcatccag      420

accaagcacg agacaggcaa gtacacccct cctaacgatg gcgcccaagt gaccgtgttc      480

ctgctggata caagcgtgca gaccgaccac cgggaaatcg agggcaaagt gatggtcacc      540

gacttcaaca gcatgcccaa agaggacggc acccggtttc acagatctgc cagcaagtgt      600

gaaagccacg gcacccatat tgccggcgtg ctgtctggaa gagatgctgg cgttgcaaga      660

ggcgtgtccg tgaataccgt gcgggtgctg aattgccaag gcagaggaac agtgtcaggc      720

gctctggccg gactcgagta tatcagagcc agtctgcagg cccagcctgt gtctcccgtg      780

atcatcctgc tgcctttcgt cggcggcttc agcagaacac tgaacaccgc ctgtcgcgag      840

atggtgcatt ctggcgctgt gctgattgcc gccgctggca actatcagga cgacgcctgt      900

atgtacagcc ccgcctctga gcctgaagtg atcacagtgg gagccagcaa cgccgccgat      960

agacctctca gctctggcac cacaggcacc aatctgggca gatgcgtgga cgttttcgcc     1020

cctggcgagg atatcatcag cgcctctggc gattgcagca cctgtttcgt gtctatgagc     1080

ggcacctctc agagcgctgc acatgccgct ggaattgctg ccgtcctgct gaacgcctat     1140

ccttctgctt ctcccgccga agtgctgcag ctgctcagat atcacgctgt gcagagagtg     1200

atcaaccccg actctctgcc tcctgagcac tacctgacca cacctgatat ggtggccgct     1260

ctgcctacat ctgccgccac aggcgaaaag ctgctgtgta gaagcgtgtg gtccaagaga     1320

agcggcgtgg gcagctttga tacagccgtg gccagatgca gacacggcga ggaaatgttc     1380

agctgctcca gctacagccc caatggcgtt cacgccggcg agagaatcga gatcagagat     1440

ggccagaaag tgtgcgaggc ccaccacgga attggaggac aaggcgtgta cgccgtggct     1500

aggtgttgta caggcagcag agtgaagtgt cacgcctctg cctcactgca tgtgggcatt     1560

gatgccgagt gtcccagcca agagtttcag ctgaccggct gcagcagcca ctacatcaga     1620

tcccaggatg tggctcagcc cagctggcca ctgcacagca atagaaaagc ctgtcctgcc     1680

ggcgaaggcg gaacaagcca tgccttttgt tgtcacgccc ctaacctgga atgccacctg     1740

atcgaacacc accagagcga gttcaccaaa caggtggaag tgtcctgcga ggacagctgg     1800

accctgacag gctgtaatgc cgtgtctcac ggctctgtga cccatgccgc ttacaccaga     1860

ggcaatacct gcgtgatcca gatgttcggc ggcgataagg gcgctgccgc cattgccatc     1920

tgctgcagat acagacccct ggaccagcag tccaacaaca accacgagca gaataccggc     1980

ggactggaag tgctgtttca aggccctgga caccaccacc atcaccactc tgcttggagc     2040

catcctcagt tcgagaagtg atga                                            2064


<210>  151
<211>  2055
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  151
atgcatctgg tgctggtgct gtgtctggct gccctggccg cctgtgatta cagcgaggac       60

caggaagtga aggcccctca gctggatcac cccgatcctg gaacagagag agtggccgag      120

ctgctgagat gcaccaagag cgtttggaga atccccgagc agtacctggt ggtgctgaga      180

gagggcacca gagatagcca cgtgcagaga accgtgtcta ccctgagagc ccaggccgct      240

agaagaggac acgccatcca catcatgcac acctacagcg gcgtgttcca cggctttctg      300

atcaagatga gcagcgaggt gctgcccatg gctctgaaac tgcctcacgt ggcctacatc      360

gaagaggact cctctatctt cgcccagagc atcccctgga acctgcagag aatcatccag      420

accaagcacg agacaggcaa gtacacccct cctaacgatg gcgcccaagt gaccgtgttc      480

ctgctggata caagcgtgca gaccgaccac cgggaaatcg agggcaaagt gatggtcacc      540

gacttcaaca gcatgcccaa agaggacggc acccggtttc acgagtctgc cagcaagtgt      600

gaaagccacg gcacccatat tgccggcgtg ctgtctggaa gagatgctgg cgttgcaaga      660

ggcgtgtccg tgaataccgt gcgggtgctg aattgccaag gcagaggaac agtgtcaggc      720

gctctggccg gactcgagta tatcagagcc agtctgcagg cccagcctgt gtctcccgtg      780

atcatcctgc tgcctttcgt cggcggcttc agcagaacac tgaacaccgc ctgtcgcgag      840

atggtgcatt ctggcgctgt gctgattgcc gccgctggca actatcagga cgacgcctgt      900

atgtacagcc ccgcctctga gcctgaagtg atcacagtgg gagccagcaa cgccgccgat      960

agacctctca gctctggcac cacaggcacc aatctgggca gatgcgtgga cgttttcgcc     1020

cctggcgagg atatcatcag cgcctctggc gattgcagca cctgtttcgt gtctatgagc     1080

ggcacctctc agagcgctgc acatgccgct ggaattgctg ccgtcctgct gaacgcctat     1140

ccttctgctt ctcccgccga agtgctgcag ctgctcagat atcacgctgt gcagagagtg     1200

atcaaccccg actctctgcc tcctgagcac tacctgacca cacctgatat ggtggccgct     1260

ctgcctacat ctgccgccac aggcgaaaag ctgctgtgta gaagcgtgtg gtccaagaga     1320

agcggcgtgg gcagctttga tacagccgtg gccagatgca gacacggcga ggaaatgttc     1380

agctgctcca gctacagccc caatggcgtt cacgccggcg agagaatcga gatcagagat     1440

ggccagaaag tgtgcgaggc ccaccacgga attggaggac aaggcgtgta cgccgtggct     1500

aggtgttgta caggcagcag agtgaagtgt cacgcctctg cctcactgca tgtgggcatt     1560

gatgccgagt gtcccagcca agagtttcag ctgaccggct gcagcagcca ctacatcaga     1620

tcccaggatg tggctcagcc cagctggcca ctgcacagca atagaaaagc ctgtcctgcc     1680

ggcgaaggcg gaacaagcca tgccttttgt tgtcacgccc ctaacctgga atgccacctg     1740

atcgaacacc accagagcga gttcaccaaa caggtggaag tgtcctgcga ggacagctgg     1800

accctgacag gctgtaatgc cgtgtctcac ggctctgtga cccatgccgc ttacaccaga     1860

ggcaatacct gcgtgatcca gatgttcggc ggcgataagg gcgctgccgc cattgccatc     1920

tgctgcagat acagacccct ggaccagcag tccaacaaca accacgagca gaataccggc     1980

ggactggtgc ccaggggcag ccaccaccac catcaccact ctgcttggag ccatcctcag     2040

ttcgagaagt gatga                                                      2055


<210>  152
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  152

Asp Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro 
1               5                   10                  15      


Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser 
            20                  25                  30          


Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr 
        35                  40                  45              


Arg Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala 
    50                  55                  60                  


Ala Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val 
65                  70                  75                  80  


Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala 
                85                  90                  95      


Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe 
            100                 105                 110         


Ala Gln 
        


<210>  153
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  153

Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu Thr 
1               5                   10                  15      


Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe Leu 
            20                  25                  30          


Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
        35                  40                  45              


Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly 
65                  70                  75                  80  


Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn 
                85                  90                  95      


Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala 
            100                 105                 110         


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val 
        115                 120                 125             


Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr 
    130                 135                 140                 


Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu Ile 
145                 150                 155                 160 


Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala 
                165                 170                 175     


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg 
            180                 185                 190         


Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp 
        195                 200                 205             


Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro 
                245                 250                 255     


Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile 
            260                 265                 270         


Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met 
        275                 280                 285             


Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys 
    290                 295                 300                 


Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala 
305                 310                 315                 320 


Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr 
                325                 330                 335     


Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly 
            340                 345                 350         


Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr 
        355                 360                 365             


Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser 
    370                 375                 380                 


Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe 
385                 390                 395                 400 


Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala 
                405                 410                 415     


Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly 
            420                 425                 430         


Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu 
        435                 440                 445             


Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu 
    450                 455                 460                 


Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser 
465                 470                 475                 480 


His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val 
                485                 490                 495     


Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys 
            500                 505                 510         


Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln 
        515                 520                 525             


Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
    530                 535                 540                 


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
545                 550                 555         


<210>  154
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  154

Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu Thr 
1               5                   10                  15      


Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe Leu 
            20                  25                  30          


Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
        35                  40                  45              


Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly 
65                  70                  75                  80  


Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn 
                85                  90                  95      


Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala 
            100                 105                 110         


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val 
        115                 120                 125             


Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr 
    130                 135                 140                 


Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu Ile 
145                 150                 155                 160 


Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala 
                165                 170                 175     


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg 
            180                 185                 190         


Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp 
        195                 200                 205             


Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro 
                245                 250                 255     


Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile 
            260                 265                 270         


Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met 
        275                 280                 285             


Val Ala Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys 
    290                 295                 300                 


Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala 
305                 310                 315                 320 


Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr 
                325                 330                 335     


Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly 
            340                 345                 350         


Gln Lys Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr 
        355                 360                 365             


Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser 
    370                 375                 380                 


Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe 
385                 390                 395                 400 


Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala 
                405                 410                 415     


Gln Pro Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly 
            420                 425                 430         


Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu 
        435                 440                 445             


Cys His Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu 
    450                 455                 460                 


Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser 
465                 470                 475                 480 


His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val 
                485                 490                 495     


Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys 
            500                 505                 510         


Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln 
        515                 520                 525             


Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
    530                 535                 540                 


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
545                 550                 555         


<210>  155
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  155

Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly Val Leu 
1               5                   10                  15      


Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn Thr Val 
            20                  25                  30          


Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala Leu Ala 
        35                  40                  45              


Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val Ser Pro 
    50                  55                  60                  


Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr Leu Asn 
65                  70                  75                  80  


Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu Ile Ala Ala 
                85                  90                  95      


Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala Ser Glu 
            100                 105                 110         


Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg Pro Leu 
        115                 120                 125             


Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp Val Phe 
    130                 135                 140                 


Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser Thr Cys 
145                 150                 155                 160 


Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His Ala Ala Gly 
                165                 170                 175     


Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro Ala Glu 
            180                 185                 190         


Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile Asn Pro 
        195                 200                 205             


Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met Val Ala 
    210                 215                 220                 


Ala Leu Pro Thr Ser Ala Ala Thr Gly Glu Lys Leu Leu Cys Arg Ser 
225                 230                 235                 240 


Val Trp Ser Lys Arg Ser Gly Val Gly Ser Phe Asp Thr Ala Val Ala 
                245                 250                 255     


Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr Ser Pro 
            260                 265                 270         


Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly Gln Lys 
        275                 280                 285             


Val Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr Ala Val 
    290                 295                 300                 


Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser Ala Ser 
305                 310                 315                 320 


Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe Gln Leu 
                325                 330                 335     


Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala Gln Pro 
            340                 345                 350         


Ser Trp Pro Leu His Ser Asn Arg Lys Ala Cys Pro Ala Gly Glu Gly 
        355                 360                 365             


Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu Cys His 
    370                 375                 380                 


Leu Ile Glu His His Gln Ser Glu Phe Thr Lys Gln Val Glu Val Ser 
385                 390                 395                 400 


Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser His Gly 
                405                 410                 415     


Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val Ile Gln 
            420                 425                 430         


Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys Cys Arg 
        435                 440                 445             


Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln Asn Thr 
    450                 455                 460                 


Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His His His 
465                 470                 475                 480 


His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
                485                 490     


<210>  156
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  156

Asp Tyr Ser Glu Asp Lys Glu Val Lys Ala Pro Gln Leu Asp His Pro 
1               5                   10                  15      


Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg Cys Thr Lys Ser 
            20                  25                  30          


Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu Arg Glu Gly Thr 
        35                  40                  45              


Arg Asp Ser His Val Gln Arg Thr Val Ser Thr Leu Arg Ala Gln Ala 
    50                  55                  60                  


Ala Arg Arg Gly His Ala Ile His Ile Met His Thr Tyr Ser Gly Val 
65                  70                  75                  80  


Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val Leu Pro Met Ala 
                85                  90                  95      


Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe 
            100                 105                 110         


Ala Gln 
        


<210>  157
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  157

Glu Val Lys Ala Pro Gln Leu Asp His Pro Asp Pro Gly Thr Glu Arg 
1               5                   10                  15      


Val Ala Glu Leu Leu Arg Cys Thr Lys Ser Val Trp Arg Ile Pro Glu 
            20                  25                  30          


Gln Tyr Leu Val Val Leu Arg Glu Gly Thr Arg Asp Ser His Val Gln 
        35                  40                  45              


Arg Thr Val Ser Thr Leu Arg Ala Gln Ala Ala Arg Arg Gly His Ala 
    50                  55                  60                  


Ile His Ile Met His Thr Tyr Ser Gly Val Phe His Gly Phe Leu Ile 
65                  70                  75                  80  


Lys Met Ser Ser Glu Val Leu Pro Met Ala Leu Lys Leu Pro His Val 
                85                  90                  95      


Ala Tyr Ile Glu Glu Asp Ser Ser Ile Phe Ala Gln 
            100                 105             


<210>  158
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  158

Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu Thr 
1               5                   10                  15      


Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Gln Val Thr Val Phe Leu 
            20                  25                  30          


Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
        35                  40                  45              


Met Val Thr Asp Phe Asn Ser Met Pro Lys Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg 
65      


<210>  159
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  159

Gly Gly Leu Val Pro Arg Gly Ser His His His His His His Ser Ala 
1               5                   10                  15      


Trp Ser His Pro Gln Phe Glu Lys 
            20                  


<210>  160
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  160

Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His His His 
1               5                   10                  15      


His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            20                  25          


<210>  161
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  161

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Lys Asn Leu Asp Cys 
1               5                   10                  15      


Trp Val Asp Asn Glu Glu Asp Ile Asp Val Ile Leu Lys Lys Ser Thr 
            20                  25                  30          


Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile Ile Ser Asp Ile Ser Gly 
        35                  40                  45              


Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp Ala Gln Leu Val Pro Gly 
    50                  55                  60                  


Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn Glu Ser Ser Glu Val 
65                  70                  75                  80  


Ile Val His Lys Ala Met Asp Ile Glu Tyr Asn Asp Met Phe Asn Asn 
                85                  90                  95      


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            100                 105                 110         


Leu Glu Gln Tyr Gly Thr Asn Glu Tyr Ser Ile Ile Ser Ser Met Lys 
        115                 120                 125             


Lys His Ser Leu Ser Ile Gly Ser Gly Trp Ser Val Ser Leu Lys Gly 
    130                 135                 140                 


Asn Asn Leu Ile Trp Thr Leu Lys Asp Ser Ala Gly Glu Val Arg Gln 
145                 150                 155                 160 


Ile Thr Phe Arg Asp Leu Pro Asp Lys Phe Asn Ala Tyr Leu Ala Asn 
                165                 170                 175     


Lys Trp Val Phe Ile Thr Ile Thr Asn Asp Arg Leu Ser Ser Ala Asn 
            180                 185                 190         


Leu Tyr Ile Asn Gly Val Leu Met Gly Ser Ala Glu Ile Thr Gly Leu 
        195                 200                 205             


Gly Ala Ile Arg Glu Asp Asn Asn Ile Thr Leu Lys Leu Asp Arg Cys 
    210                 215                 220                 


Asn Asn Asn Asn Gln Tyr Val Ser Ile Asp Lys Phe Arg Ile Phe Cys 
225                 230                 235                 240 


Lys Ala Leu Asn Pro Lys Glu Ile Glu Lys Leu Tyr Thr Ser Tyr Leu 
                245                 250                 255     


Ser Ile Thr Phe Leu Arg Asp Phe Trp Gly Asn Pro Leu Arg Tyr Asp 
            260                 265                 270         


Thr Glu Tyr Tyr Leu Ile Pro Val Ala Ser Ser Ser Lys Asp Val Gln 
        275                 280                 285             


Leu Lys Asn Ile Thr Asp Tyr Met Tyr Leu Thr Asn Ala Pro Ser Tyr 
    290                 295                 300                 


Thr Asn Gly Lys Leu Asn Ile Tyr Tyr Arg Arg Leu Tyr Asn Gly Leu 
305                 310                 315                 320 


Lys Phe Ile Ile Lys Arg Tyr Thr Pro Asn Asn Glu Ile Asp Ser Phe 
                325                 330                 335     


Val Lys Ser Gly Asp Phe Ile Lys Leu Tyr Val Ser Tyr Asn Asn Asn 
            340                 345                 350         


Glu His Ile Val Gly Tyr Pro Lys Asp Gly Asn Ala Phe Asn Asn Leu 
        355                 360                 365             


Asp Arg Ile Leu Arg Val Gly Tyr Asn Ala Pro Gly Ile Pro Leu Tyr 
    370                 375                 380                 


Lys Lys Met Glu Ala Val Lys Leu Arg Asp Leu Lys Thr Tyr Ser Val 
385                 390                 395                 400 


Gln Leu Lys Leu Tyr Asp Asp Lys Asn Ala Ser Leu Gly Leu Val Gly 
                405                 410                 415     


Thr His Asn Gly Gln Ile Gly Asn Asp Pro Asn Arg Asp Ile Leu Ile 
            420                 425                 430         


Ala Ser Asn Trp Tyr Phe Asn His Leu Lys Asp Lys Ile Leu Gly Cys 
        435                 440                 445             


Asp Trp Tyr Phe Val Pro Thr Asp Glu Gly Trp Thr Asn Asp Gly Gly 
    450                 455                 460                 


Gly Leu Val Pro Gln Gln Ser Gly Ala His Ile Val Met Val Asp Ala 
465                 470                 475                 480 


Tyr Lys Pro Thr Lys Gly Ser Gly His His His His His His Ser Ala 
                485                 490                 495     


Trp Ser His Pro Gln Phe Glu Lys 
            500                 


<210>  162
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  162

Gly Gly Gly Leu Val Pro Gln Gln Ser Gly Ala His Ile Val Met Val 
1               5                   10                  15      


Asp Ala Tyr Lys Pro Thr Lys Gly Ser Gly His His His His His His 
            20                  25                  30          


Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        35                  40          


<210>  163
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  163

Ser Ile Pro Trp Asn Leu Gln Arg Ile Ile Gln Thr Lys His Glu Thr 
1               5                   10                  15      


Gly Lys Tyr Thr Pro Pro Asn Asp Gly Ala Asn Val Ser Val Phe Leu 
            20                  25                  30          


Leu Asp Thr Ser Val Gln Thr Asp His Arg Glu Ile Glu Gly Lys Val 
        35                  40                  45              


Met Val Thr Asp Phe Asn Ser Ser Pro Lys Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Glu Ser Ala Ser Lys Cys Glu Ser His Gly Thr His Ile Ala Gly 
65                  70                  75                  80  


Val Leu Ser Gly Arg Asp Ala Gly Val Ala Arg Gly Val Ser Val Asn 
                85                  90                  95      


Thr Val Arg Val Leu Asn Cys Gln Gly Arg Gly Thr Val Ser Gly Ala 
            100                 105                 110         


Leu Ala Gly Leu Glu Tyr Ile Arg Ala Ser Leu Gln Ala Gln Pro Val 
        115                 120                 125             


Ser Pro Val Ile Ile Leu Leu Pro Phe Val Gly Gly Phe Ser Arg Thr 
    130                 135                 140                 


Leu Asn Thr Ala Cys Arg Glu Met Val His Ser Gly Ala Val Leu Ile 
145                 150                 155                 160 


Ala Ala Ala Gly Asn Tyr Gln Asp Asp Ala Cys Met Tyr Ser Pro Ala 
                165                 170                 175     


Ser Glu Pro Glu Val Ile Thr Val Gly Ala Ser Asn Ala Ala Asp Arg 
            180                 185                 190         


Pro Leu Ser Ser Gly Thr Thr Gly Thr Asn Leu Gly Arg Cys Val Asp 
        195                 200                 205             


Val Phe Ala Pro Gly Glu Asp Ile Ile Ser Ala Ser Gly Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Met Ser Gly Thr Ser Gln Ser Ala Ala His Ala 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Val Leu Leu Asn Ala Tyr Pro Ser Ala Ser Pro 
                245                 250                 255     


Ala Glu Val Leu Gln Leu Leu Arg Tyr His Ala Val Gln Arg Val Ile 
            260                 265                 270         


Asn Pro Asp Ser Leu Pro Pro Glu His Tyr Leu Thr Thr Pro Asp Met 
        275                 280                 285             


Val Ala Ala Leu Pro Thr Ser Ala Ala Asn Gly Thr Lys Leu Leu Cys 
    290                 295                 300                 


Arg Ser Val Trp Ser Lys Arg Ser Gly Val Gly Ser Asn Asp Ser Ala 
305                 310                 315                 320 


Val Ala Arg Cys Arg His Gly Glu Glu Met Phe Ser Cys Ser Ser Tyr 
                325                 330                 335     


Ser Pro Asn Gly Val His Ala Gly Glu Arg Ile Glu Ile Arg Asp Gly 
            340                 345                 350         


Asn Lys Ser Cys Glu Ala His His Gly Ile Gly Gly Gln Gly Val Tyr 
        355                 360                 365             


Ala Val Ala Arg Cys Cys Thr Gly Ser Arg Val Lys Cys His Ala Ser 
    370                 375                 380                 


Ala Ser Leu His Val Gly Ile Asp Ala Glu Cys Pro Ser Gln Glu Phe 
385                 390                 395                 400 


Gln Leu Thr Gly Cys Ser Ser His Tyr Ile Arg Ser Gln Asp Val Ala 
                405                 410                 415     


Gln Pro Ser Trp Pro Leu His Asn Asn Ser Lys Ala Cys Pro Ala Gly 
            420                 425                 430         


Glu Gly Gly Thr Ser His Ala Phe Cys Cys His Ala Pro Asn Leu Glu 
        435                 440                 445             


Cys His Leu Ile Glu His His Gln Ser Glu Asn Thr Thr Gln Val Glu 
    450                 455                 460                 


Val Ser Cys Glu Asp Ser Trp Thr Leu Thr Gly Cys Asn Ala Val Ser 
465                 470                 475                 480 


His Gly Ser Val Thr His Ala Ala Tyr Thr Arg Gly Asn Thr Cys Val 
                485                 490                 495     


Ile Gln Met Phe Gly Gly Asp Lys Gly Ala Ala Ala Ile Ala Ile Cys 
            500                 505                 510         


Cys Arg Tyr Arg Pro Leu Asp Gln Gln Ser Asn Asn Asn His Glu Gln 
        515                 520                 525             


Asn Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro Gly His His His 
    530                 535                 540                 


His His His Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
545                 550                 555         


<210>  164
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  164

Gln Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly 
1               5                   10                  15      


Gly Ser Gly Gly Asp Tyr Ser Glu Asp Gln Glu Val Lys Ala Pro Gln 
            20                  25                  30          


Leu Asp His Pro Asp Pro Gly Thr Glu Arg Val Ala Glu Leu Leu Arg 
        35                  40                  45              


Cys Thr Lys Ser Val Trp Arg Ile Pro Glu Gln Tyr Leu Val Val Leu 
    50                  55                  60                  


Arg Glu Gly Thr Asn Asp Thr His Val Gln Arg Thr Val Ser Thr Leu 
65                  70                  75                  80  


Arg Ala Gln Ala Ala Arg Arg Gly Asn Ala Thr His Ile Met His Thr 
                85                  90                  95      


Tyr Ser Gly Val Phe His Gly Phe Leu Ile Lys Met Ser Ser Glu Val 
            100                 105                 110         


Leu Pro Met Ala Leu Lys Leu Pro His Val Ala Tyr Ile Glu Glu Asp 
        115                 120                 125             


Ser Ser Ile Phe Ala Gln 
    130                 


