                         SEQUENCE LISTING

<110>  Immatics US, Inc.
 
<120>  CD8 POLYPEPTIDES, COMPOSITIONS, AND METHODS OF USING THEREOF


<130>  3000011-022977

<150>  63/132,824
<151>  2020-12-31

<150>  63/247,775
<151>  2021-09-23

<150>  10 2021 100 038.6
<151>  2021-01-04

<160>  304   

<170>  PatentIn version 3.5

<210>  1
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha Ig-like domain-1

<400>  1

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala 
        


<210>  2
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8beta stalk region

<400>  2

Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser 
1               5                   10                  15      


Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys 
            20                  25                  30          


Gly Pro Leu Cys Ser Pro 
        35              


<210>  3
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha transmembrane domain

<400>  3

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  4
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha cytoplasmic tail

<400>  4

Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
1               5                   10                  15      


Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  25                  30          


<210>  5
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m1CD8alpha (signal-less)

<400>  5

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys 
        115                 120                 125             


Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr 
    130                 135                 140                 


Gln Lys Gly Pro Leu Cys Ser Pro Ile Tyr Ile Trp Ala Pro Leu Ala 
145                 150                 155                 160 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                165                 170                 175     


Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val 
            180                 185                 190         


Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
        195                 200                 205 


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  7
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m1CD8alpha

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Ser Val Val Asp Phe Leu Pro Thr Thr 
    130                 135                 140                 


Ala Gln Pro Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu 
145                 150                 155                 160 


Pro Arg Pro Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Tyr Ile 
                165                 170                 175     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            180                 185                 190         


Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys 
        195                 200                 205             


Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg 
    210                 215                 220                 


Tyr Val 
225     


<210>  8
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro 
        195                 200                 205             


Gln Gly Glu Gly Ile Ser Gly Thr Phe Val Pro Gln Cys Leu His Gly 
    210                 215                 220                 


Tyr Tyr Ser Asn Thr Thr Thr Ser Gln Lys Leu Leu Asn Pro Trp Ile 
225                 230                 235                 240 


Leu Lys Thr 
            


<210>  9
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Leu Lys Gly Lys Val Tyr Gln Glu Pro Leu Ser 
                165                 170                 175     


Pro Asn Ala Cys Met Asp Thr Thr Ala Ile Leu Gln Pro His Arg Ser 
            180                 185                 190         


Cys Leu Thr His Gly Ser 
        195             


<210>  10
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe Tyr Lys 
            180                 185                 


<210>  11
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Leu Arg Leu His Pro Leu 
            180                 185                 190         


Glu Lys Cys Ser Arg Met Asp Tyr 
        195                 200 


<210>  12
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Lys Phe Asn Ile Val Cys 
            180                 185                 190         


Leu Lys Ile Ser Gly Phe Thr Thr Cys Cys Cys Phe Gln Ile Leu Gln 
        195                 200                 205             


Ile Ser Arg Glu Tyr Gly Phe Gly Val Leu Leu Gln Lys Asp Ile Gly 
    210                 215                 220                 


Gln 
225 


<210>  13
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Lys Phe Asn Ile Val Cys 
            180                 185                 190         


Leu Lys Ile Ser Gly Phe Thr Thr Cys Cys Cys Phe Gln Ile Leu Gln 
        195                 200                 205             


Ile Ser Arg Glu Tyr Gly Phe Gly Val Leu Leu Gln Lys Asp Ile Gly 
    210                 215                 220                 


Gln 
225 


<210>  14
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro Gln Gly Glu Gly Ile 
            180                 185                 190         


Ser Gly Thr Phe Val Pro Gln Cys Leu His Gly Tyr Tyr Ser Asn Thr 
        195                 200                 205             


Thr Thr Ser Gln Lys Leu Leu Asn Pro Trp Ile Leu Lys Thr 
    210                 215                 220         


<210>  15
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11KEA alpha chain

<400>  15

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  16
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11KE beta chain

<400>  16

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  17
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R20P1H7 alpha chain

<400>  17

Met Glu Lys Met Leu Glu Cys Ala Phe Ile Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Gly Trp Leu Ser Gly Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu 
            20                  25                  30          


Arg Leu Gln Glu Gly Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val 
        35                  40                  45              


Ser Gly Leu Arg Gly Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly 
    50                  55                  60                  


Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys 
65                  70                  75                  80  


Glu Arg Leu Lys Ala Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile 
                85                  90                  95      


Thr Ala Pro Lys Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Gln 
            100                 105                 110         


Gly Glu Asn Ser Gly Tyr Ser Thr Leu Thr Phe Gly Lys Gly Thr Met 
        115                 120                 125             


Leu Leu Val Ser Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  18
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R20P1H7 beta chain

<400>  18

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Pro Gly Leu Ala Ala Tyr Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  19
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R7P1D5 alpha chain

<400>  19

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Tyr Ser Ser Ala Ser Lys Ile Ile Phe Gly Ser Gly Thr Arg Leu Ser 
        115                 120                 125             


Ile Arg Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  20
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R7P1D5 beta chain

<400>  20

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Arg Ala Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  21
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R10P2G12 alpha chain

<400>  21

Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Gly Asn Ser Gly Asn Thr Pro Leu Val Phe Gly Lys 
        115                 120                 125             


Gly Thr Arg Leu Ser Val Ile Ala Asn Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  22
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R10P2G12 beta chain

<400>  22

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ser Ser Gly Ser His Gln Glu Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310             


<210>  23
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R10P1A7 alpha chain

<400>  23

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ser Lys Glu Thr Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val Val 
        115                 120                 125             


Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  24
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R10P1A7 beta chain

<400>  24

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Trp Ser Gln His Pro 
            20                  25                  30          


Ser Val Trp Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg 
        35                  40                  45              


Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro 
    50                  55                  60                  


Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala 
65                  70                  75                  80  


Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala 
                85                  90                  95      


Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp 
            100                 105                 110         


Ser Ser Phe Tyr Ile Cys Ser Ala Arg Ala Gly Gly His Glu Gln Phe 
        115                 120                 125             


Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val 
    130                 135                 140                 


Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser 
145                 150                 155                 160 


His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro 
                165                 170                 175     


Asp His Val Glu Leu Ser Trp Val Trp Asn Gly Lys Glu Val His Ser 
            180                 185                 190         


Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn 
        195                 200                 205             


Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe 
    210                 215                 220                 


Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly 
225                 230                 235                 240 


Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr 
                245                 250                 255     


Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr 
            260                 265                 270         


Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu 
        275                 280                 285             


Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu 
    290                 295                 300                 


Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 315         


<210>  25
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R4P1D10 alpha chain

<400>  25

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe His Asp Lys Ile Ile Phe Gly Lys Gly Thr Arg Leu His Ile 
        115                 120                 125             


Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  26
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R4P1D10 beta chain

<400>  26

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile His Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Ala Ser Ala Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Phe 
305             


<210>  27
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R4P3F9 alpha chain

<400>  27

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala 
            100                 105                 110         


Tyr Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
        115                 120                 125             


Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  28
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R4P3F9 beta chain

<400>  28

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Glu Ser Ser Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Phe 
305             


<210>  29
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R4P3H3 alpha chain

<400>  29

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Lys Ala Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val 
        115                 120                 125             


Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  30
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R4P3H3 beta chain

<400>  30

Met Gly Thr Arg Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Ala 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Phe Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Phe Ala Glu Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Leu Thr Ser Gly Gly Asp Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  31
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R36P3F9 alpha chain

<400>  31

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Val 
            100                 105                 110         


Ser Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys 
        115                 120                 125             


Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  32
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R36P3F9 beta chain

<400>  32

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ser Thr Ser Gly Gly Leu Ser Gly Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  33
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R52P2G11 alpha chain

<400>  33

Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Ala Tyr Gly Lys Leu Gln Phe Gly Ala Gly Thr Gln Val Val 
        115                 120                 125             


Val Thr Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  34
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R52P2G11 beta chain

<400>  34

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asn Ser Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Ser Pro Asp Gly Asn Gln Pro Gln His Phe Gly Asp 
        115                 120                 125             


Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe 
305                 310         


<210>  35
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R53P2A9 alpha chain

<400>  35

Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      


Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Tyr Asn Ser Tyr Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe 
        115                 120                 125             


Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile Gln Asn Pro Asp 
    130                 135                 140                 


Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val 
145                 150                 155                 160 


Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys 
                165                 170                 175     


Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser 
            180                 185                 190         


Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp 
        195                 200                 205             


Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr 
    210                 215                 220                 


Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys 
225                 230                 235                 240 


Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile 
                245                 250                 255     


Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
            260                 265                 270         


Thr Leu Arg Leu Trp Ser Ser 
        275                 


<210>  36
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R53P2A9 beta chain

<400>  36

Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Lys Ser Val Ser Trp Tyr Gln Gln Val Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Lys Glu Glu Arg Gly Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Ala Arg Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Asp Gly Thr Ser Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  37
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R26P1A9 alpha chain

<400>  37

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Leu Ile Gly 
            100                 105                 110         


Ala Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val 
        115                 120                 125             


Asn Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  38
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R26P1A9 beta chain

<400>  38

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Tyr Phe Gly Trp Asn Glu Lys Leu Phe Phe Gly Ser Gly Thr 
        115                 120                 125             


Gln Leu Ser Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Phe 
305                 310 


<210>  39
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R26P2A6 alpha chain

<400>  39

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Ser Asp Val Ser Gly Gly Tyr Asn Lys Leu Ile Phe Gly Ala Gly 
        115                 120                 125             


Thr Arg Leu Ala Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  40
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R26P2A6 beta chain

<400>  40

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Thr Thr Pro Asp Gly Thr Asp Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  41
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R26P3H1 alpha chain

<400>  41

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Met Asn Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr Arg 
        115                 120                 125             


Leu His Ile Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  42
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R26P3H1 beta chain

<400>  42

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Ala Glu Gly Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  43
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R35P3A4 alpha chain

<400>  43

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Pro Thr Gly Gly Tyr Asn Lys Leu Ile Phe Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Ala Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  44
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R35P3A4 beta chain

<400>  44

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Gly Ala Ser Gln Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  45
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R37P1C9 alpha chain

<400>  45

Met Lys Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
            20                  25                  30          


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
        35                  40                  45              


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
    50                  55                  60                  


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
65                  70                  75                  80  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
                85                  90                  95      


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Ile Leu Phe Asn Phe Asn Lys 
            100                 105                 110         


Phe Tyr Phe Gly Ser Gly Thr Lys Leu Asn Val Lys Pro Asn Ile Gln 
        115                 120                 125             


Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp 
    130                 135                 140                 


Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser 
145                 150                 155                 160 


Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp 
                165                 170                 175     


Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn 
            180                 185                 190         


Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro 
        195                 200                 205             


Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu 
    210                 215                 220                 


Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu 
225                 230                 235                 240 


Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
                245                 250                 255     


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265     


<210>  46
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R37P1C9 beta chain

<400>  46

Met Gly Pro Gly Leu Leu His Trp Met Ala Leu Cys Leu Leu Gly Thr 
1               5                   10                  15      


Gly His Gly Asp Ala Met Val Ile Gln Asn Pro Arg Tyr Gln Val Thr 
            20                  25                  30          


Gln Phe Gly Lys Pro Val Thr Leu Ser Cys Ser Gln Thr Leu Asn His 
        35                  40                  45              


Asn Val Met Tyr Trp Tyr Gln Gln Lys Ser Ser Gln Ala Pro Lys Leu 
    50                  55                  60                  


Leu Phe His Tyr Tyr Asp Lys Asp Phe Asn Asn Glu Ala Asp Thr Pro 
65                  70                  75                  80  


Asp Asn Phe Gln Ser Arg Arg Pro Asn Thr Ser Phe Cys Phe Leu Asp 
                85                  90                  95      


Ile Arg Ser Pro Gly Leu Gly Asp Ala Ala Met Tyr Leu Cys Ala Thr 
            100                 105                 110         


Ser Ser Gly Glu Thr Asn Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln 
        115                 120                 125             


Leu Ser Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Phe 
305                 


<210>  47
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R37P1H1 alpha chain

<400>  47

Met Thr Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu 
1               5                   10                  15      


Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Phe Gly Tyr Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr His Leu Ile Ile Gln Pro Tyr Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  48
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R37P1H1 beta chain

<400>  48

Met Gly Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His 
        35                  40                  45              


Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Asn Glu Gly Gln Gly Trp Glu Ala Glu Ala Phe Phe Gly Gln Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Phe 
305                 310     


<210>  49
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R42P3A9 alpha chain

<400>  49

Met Lys Arg Ile Leu Gly Ala Leu Leu Gly Leu Leu Ser Ala Gln Val 
1               5                   10                  15      


Cys Cys Val Arg Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile 
            20                  25                  30          


Leu Gln Glu Gly Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser 
        35                  40                  45              


Val Asn Asn Leu Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile 
    50                  55                  60                  


Asn Leu Phe Tyr Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser 
65                  70                  75                  80  


Ala Thr Thr Val Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser 
                85                  90                  95      


Ser Gln Thr Thr Asp Ser Gly Val Tyr Phe Cys Ala Val His Asn Phe 
            100                 105                 110         


Asn Lys Phe Tyr Phe Gly Ser Gly Thr Lys Leu Asn Val Lys Pro Asn 
        115                 120                 125             


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
    130                 135                 140                 


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
145                 150                 155                 160 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
                165                 170                 175     


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
            180                 185                 190         


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
        195                 200                 205             


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
    210                 215                 220                 


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  50
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R42P3A9 beta chain

<400>  50

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Leu Gly Gln Gly 
        115                 120                 125             


Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu 
    130                 135                 140                 


Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
145                 150                 155                 160 


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
                165                 170                 175     


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
            180                 185                 190         


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
        195                 200                 205             


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
    210                 215                 220                 


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
225                 230                 235                 240 


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
                245                 250                 255     


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
            260                 265                 270         


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
        275                 280                 285             


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
    290                 295                 300                 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser 
305                 310                 315                 320 


Arg Gly 
        


<210>  51
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R43P3F2 alpha chain

<400>  51

Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Asn Asn Asn Ala Gly Asn Met Leu Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  52
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R43P3F2 beta chain

<400>  52

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Pro Thr Gly Thr Ser 
        115                 120                 125             


Gly Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
    130                 135                 140                 


Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
145                 150                 155                 160 


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
                165                 170                 175     


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
            180                 185                 190         


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
        195                 200                 205             


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
    210                 215                 220                 


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
225                 230                 235                 240 


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
                245                 250                 255     


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
            260                 265                 270         


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
        275                 280                 285             


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
    290                 295                 300                 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
305                 310                 315                 320 


Ser Arg Gly 
            


<210>  53
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R43P3G5 alpha chain

<400>  53

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Leu Asn Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr Arg Leu 
        115                 120                 125             


His Ile Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  54
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R43P3G5 beta chain

<400>  54

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Arg Leu Pro Ser Arg Thr Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  55
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R59P2E7 alpha chain

<400>  55

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn 
            100                 105                 110         


Ser Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg 
        115                 120                 125             


Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  56
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R59P2E7 beta chain

<400>  56

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Gly Leu Gly Thr 
        115                 120                 125             


Gly Asp Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val Val 
    130                 135                 140                 


Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
145                 150                 155                 160 


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
                165                 170                 175     


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
            180                 185                 190         


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
        195                 200                 205             


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
    210                 215                 220                 


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
225                 230                 235                 240 


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
                245                 250                 255     


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
            260                 265                 270         


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
        275                 280                 285             


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
    290                 295                 300                 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
305                 310                 315                 320 


Phe 
    


<210>  57
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11P3D3 alpha chain

<400>  57

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  58
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11P3D3 beta chain

<400>  58

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asn Ser Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Leu Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  59
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R16P1C10 alpha chain

<400>  59

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala 
            100                 105                 110         


Val Ile Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Arg Leu Thr Ile Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210>  60
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R16P1C10 beta chain

<400>  60

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Pro Trp Asp Ser Pro Asn Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  61
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R16P1E8 alpha chain

<400>  61

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Ser Glu Ala Ala Gly Asn Lys Leu Thr Phe Gly Gly Gly Thr Arg 
        115                 120                 125             


Val Leu Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  62
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R16P1E8 beta chain

<400>  62

Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Tyr Thr Asn Gln Gly Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Phe 
305                 


<210>  63
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R17P1A9 alpha chain

<400>  63

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Leu Asn Gln Ala Gly Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu 
        115                 120                 125             


Ser Val Ser Ser Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  64
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R17P1A9 beta chain

<400>  64

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ala Glu Thr Gly Pro Trp Leu Gly Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  65
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R17P1D7 alpha chain

<400>  65

Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      


Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Tyr Arg Trp Ala Gln Gly Gly Ser Glu Lys Leu Val Phe Gly Lys 
        115                 120                 125             


Gly Thr Lys Leu Thr Val Asn Pro Tyr Ile Gln Lys Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  66
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R17P1D7 beta chain

<400>  66

Met Thr Ile Arg Leu Leu Cys Tyr Met Gly Phe Tyr Phe Leu Gly Ala 
1               5                   10                  15      


Gly Leu Met Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile 
            20                  25                  30          


Gly Thr Gly Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His 
        35                  40                  45              


Asp Lys Met Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser 
65                  70                  75                  80  


Ser Glu Ser Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Thr 
            100                 105                 110         


Glu Leu Trp Ser Ser Gly Gly Thr Gly Glu Leu Phe Phe Gly Glu Gly 
        115                 120                 125             


Ser Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310             


<210>  67
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R17P1G3 alpha chain

<400>  67

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Gly Pro Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Lys Val Leu Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  68
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R17P1G3 beta chain

<400>  68

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Gly Gly Ser Gly Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  69
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R17P2B6 alpha chain

<400>  69

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Val Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr His 
        115                 120                 125             


Leu Ile Ile Gln Pro Tyr Ile Gln Lys Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  70
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R17P2B6 beta chain

<400>  70

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Gly Arg Gly Gly 
        115                 120                 125             


Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp 
    130                 135                 140                 


Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu 
145                 150                 155                 160 


Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr 
                165                 170                 175     


Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys 
            180                 185                 190         


Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln 
        195                 200                 205             


Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val 
    210                 215                 220                 


Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val 
225                 230                 235                 240 


Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala 
                245                 250                 255     


Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp 
            260                 265                 270         


Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
        275                 280                 285             


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
    290                 295                 300                 


Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
305                 310                 315                 


<210>  71
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11P3D3KE alpha chain

<400>  71

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  72
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11P3D3KE beta chain

<400>  72

Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe 
1               5                   10                  15      


Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro 
            20                  25                  30          


Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly 
        35                  40                  45              


Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
    50                  55                  60                  


Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
65                  70                  75                  80  


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
                85                  90                  95      


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
            100                 105                 110         


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
        115                 120                 125             


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
    130                 135                 140                 


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
145                 150                 155                 160 


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
                165                 170                 175     


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
            180                 185                 190         


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
        195                 200                 205             


Ala Thr Leu Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
    210                 215                 220                 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
225                 230                 235                 240 


Ser Arg Gly 
            


<210>  73
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R39P1C12 alpha chain

<400>  73

Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu Gln Leu 
1               5                   10                  15      


Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln Arg Leu 
            20                  25                  30          


Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg Ile Ala 
        35                  40                  45              


Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu Ile Asp 
    50                  55                  60                  


Asn Gln Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val 
65                  70                  75                  80  


Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
                85                  90                  95      


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
            100                 105                 110         


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
        115                 120                 125             


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
    130                 135                 140                 


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
145                 150                 155                 160 


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
                165                 170                 175     


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
            180                 185                 190         


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
        195                 200                 205             


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    210                 215                 220             


<210>  74
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R39P1C12 beta chain

<400>  74

Met Gly Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His 
        35                  40                  45              


Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Leu Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe 
    130                 135                 140                 


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
            180                 185                 190         


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
225                 230                 235                 240 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asp Phe 
305         


<210>  75
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R39P1F5 alpha chain

<400>  75

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Asn Ala Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val Val Lys 
        115                 120                 125             


Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  76
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R39P1F5 beta chain

<400>  76

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gly Gln Gly Ala Asn Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  77
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R40P1C2 alpha chain

<400>  77

Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      


Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Tyr Leu Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile 
        115                 120                 125             


Ile Lys Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  78
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R40P1C2 beta chain

<400>  78

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Glu Met Thr Ala Val Gly Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  79
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R41P3E6 alpha chain

<400>  79

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala 
            100                 105                 110         


Phe Ser Gly Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val 
        115                 120                 125             


Thr Pro His Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  80
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R41P3E6 beta chain

<400>  80

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gln Tyr Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  81
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R43P3G4 alpha chain

<400>  81

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Gly Gly Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys 
        115                 120                 125             


Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  82
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R43P3G4 beta chain

<400>  82

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gly Gln Gly Ala Leu Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  83
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R44P3B3 alpha chain

<400>  83

Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro 
1               5                   10                  15      


Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln 
            20                  25                  30          


Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn 
        35                  40                  45              


Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys 
    50                  55                  60                  


Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys 
65                  70                  75                  80  


Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala 
                85                  90                  95      


Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Ala Ser Gly Leu Tyr Asn Gln Gly Gly Lys Leu 
        115                 120                 125             


Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys Pro Asn Ile Gln Asn 
    130                 135                 140                 


Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys 
145                 150                 155                 160 


Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln 
                165                 170                 175     


Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met 
            180                 185                 190         


Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys 
        195                 200                 205             


Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu 
    210                 215                 220                 


Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val 
225                 230                 235                 240 


Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser 
                245                 250                 255     


Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
            260                 265                 270         


Leu Met Thr Leu Arg Leu Trp Ser Ser 
        275                 280     


<210>  84
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R44P3B3 beta chain

<400>  84

Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Asp Arg Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  85
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R44P3E7 alpha chain

<400>  85

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ile Asn Asn Asn Ala Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  86
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R44P3E7 beta chain

<400>  86

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Pro Pro Asp Gln Asn 
        115                 120                 125             


Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu 
    130                 135                 140                 


Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala 
145                 150                 155                 160 


Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly 
                165                 170                 175     


Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         


Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro 
        195                 200                 205             


Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
    210                 215                 220                 


Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
225                 230                 235                 240 


Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys 
                245                 250                 255     


Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
            260                 265                 270         


Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
        275                 280                 285             


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
    290                 295                 300                 


Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 315                 320 


<210>  87
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R49P2B7 alpha chain

<400>  87

Met Leu Leu Leu Leu Val Pro Val Leu Glu Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Gly Ser His Val Ser Val 
            20                  25                  30          


Ser Glu Gly Ala Leu Val Leu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Pro Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Thr Thr Gly Ala Thr Leu Val Lys Gly Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Lys Lys Ser Glu Thr Ser Phe His Leu Thr 
                85                  90                  95      


Lys Pro Ser Ala His Met Ser Asp Ala Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Ile Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Thr Ile Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  88
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R49P2B7 beta chain

<400>  88

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Met Gly Glu Leu Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Ser Arg Gly 
305                 310         


<210>  89
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R55P1G7 alpha chain

<400>  89

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Met Gly Asp Thr Gly Thr Ala Ser Lys Leu Thr Phe Gly Thr Gly 
        115                 120                 125             


Thr Arg Leu Gln Val Thr Leu Asp Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  90
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R55P1G7 beta chain

<400>  90

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Phe Gly Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
    130                 135                 140                 


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
            180                 185                 190         


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
225                 230                 235                 240 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asp Ser Arg Gly 
305                 


<210>  91
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R59P2A7 alpha chain

<400>  91

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Gln Pro His Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys 
        115                 120                 125             


Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  92
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R59P2A7 beta chain

<400>  92

Met Leu Cys Ser Leu Leu Ala Leu Leu Leu Gly Thr Phe Phe Gly Val 
1               5                   10                  15      


Arg Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu 
    50                  55                  60                  


Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys 
                85                  90                  95      


Lys Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Gly 
            100                 105                 110         


Leu Val Ala Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
        115                 120                 125             


Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
    130                 135                 140                 


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
                165                 170                 175     


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
            180                 185                 190         


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
225                 230                 235                 240 


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
    290                 295                 300                 


Ser Arg Gly 
305         


<210>  93
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  93

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  94
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  94

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  95
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A

<400>  95

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  96
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A

<400>  96

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  97
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RD114TR

<400>  97

Met Lys Leu Pro Thr Gly Met Val Ile Leu Cys Ser Leu Ile Ile Val 
1               5                   10                  15      


Arg Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Ala Leu Val Gln Lys 
            20                  25                  30          


Gln His Gly Lys Pro Cys Glu Cys Ser Gly Gly Gln Val Ser Glu Ala 
        35                  40                  45              


Pro Pro Asn Ser Ile Gln Gln Val Thr Cys Pro Gly Lys Thr Ala Tyr 
    50                  55                  60                  


Leu Met Thr Asn Gln Lys Trp Lys Cys Arg Val Thr Pro Lys Ile Ser 
65                  70                  75                  80  


Pro Ser Gly Gly Glu Leu Gln Asn Cys Pro Cys Asn Thr Phe Gln Asp 
                85                  90                  95      


Ser Met His Ser Ser Cys Tyr Thr Glu Tyr Arg Gln Cys Arg Arg Ile 
            100                 105                 110         


Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Ile Arg Ser Gly Ser 
        115                 120                 125             


Leu Asn Glu Val Gln Ile Leu Gln Asn Pro Asn Gln Leu Leu Gln Ser 
    130                 135                 140                 


Pro Cys Arg Gly Ser Ile Asn Gln Pro Val Cys Trp Ser Ala Thr Ala 
145                 150                 155                 160 


Pro Ile His Ile Ser Asp Gly Gly Gly Pro Leu Asp Thr Lys Arg Val 
                165                 170                 175     


Trp Thr Val Gln Lys Arg Leu Glu Gln Ile His Lys Ala Met Thr Pro 
            180                 185                 190         


Glu Leu Gln Tyr His Pro Leu Ala Leu Pro Lys Val Arg Asp Asp Leu 
        195                 200                 205             


Ser Leu Asp Ala Arg Thr Phe Asp Ile Leu Asn Thr Thr Phe Arg Leu 
    210                 215                 220                 


Leu Gln Met Ser Asn Phe Ser Leu Ala Gln Asp Cys Trp Leu Cys Leu 
225                 230                 235                 240 


Lys Leu Gly Thr Pro Thr Pro Leu Ala Ile Pro Thr Pro Ser Leu Thr 
                245                 250                 255     


Tyr Ser Leu Ala Asp Ser Leu Ala Asn Ala Ser Cys Gln Ile Ile Pro 
            260                 265                 270         


Pro Leu Leu Val Gln Pro Met Gln Phe Ser Asn Ser Ser Cys Leu Ser 
        275                 280                 285             


Ser Pro Phe Ile Asn Asp Thr Glu Gln Ile Asp Leu Gly Ala Val Thr 
    290                 295                 300                 


Phe Thr Asn Cys Thr Ser Val Ala Asn Val Ser Ser Pro Leu Cys Ala 
305                 310                 315                 320 


Leu Asn Gly Ser Val Phe Leu Cys Gly Asn Asn Met Ala Tyr Thr Tyr 
                325                 330                 335     


Leu Pro Gln Asn Trp Thr Arg Leu Cys Val Gln Ala Ser Leu Leu Pro 
            340                 345                 350         


Asp Ile Asp Ile Asn Pro Gly Asp Glu Pro Val Pro Ile Pro Ala Ile 
        355                 360                 365             


Asp His Tyr Ile His Arg Pro Lys Arg Ala Val Gln Phe Ile Pro Leu 
    370                 375                 380                 


Leu Ala Gly Leu Gly Ile Thr Ala Ala Phe Thr Thr Gly Ala Thr Gly 
385                 390                 395                 400 


Leu Gly Val Ser Val Thr Gln Tyr Thr Lys Leu Ser His Gln Leu Ile 
                405                 410                 415     


Ser Asp Val Gln Val Leu Ser Gly Thr Ile Gln Asp Leu Gln Asp Gln 
            420                 425                 430         


Val Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp 
        435                 440                 445             


Leu Leu Thr Ala Glu Gln Gly Gly Ile Cys Leu Ala Leu Gln Glu Lys 
    450                 455                 460                 


Cys Cys Phe Tyr Ala Asn Lys Ser Gly Ile Val Arg Asn Lys Ile Arg 
465                 470                 475                 480 


Thr Leu Gln Glu Glu Leu Gln Lys Arg Arg Glu Ser Leu Ala Ser Asn 
                485                 490                 495     


Pro Leu Trp Thr Gly Leu Gln Gly Phe Leu Pro Tyr Leu Leu Pro Leu 
            500                 505                 510         


Leu Gly Pro Leu Leu Thr Leu Leu Leu Ile Leu Thr Ile Gly Pro Cys 
        515                 520                 525             


Val Phe Asn Arg Leu Val Gln Phe Val Lys Asp Arg Ile Ser Val Val 
    530                 535                 540                 


Gln Ala Leu Val Leu Thr Gln Gln Tyr His Gln Leu Lys Pro Leu 
545                 550                 555                 


<210>  98
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  98

Tyr Leu Tyr Asp Ser Glu Thr Lys Asn Ala 
1               5                   10  


<210>  99
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  99

His Leu Met Asp Gln Pro Leu Ser Val 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  100

Gly Leu Leu Lys Lys Ile Asn Ser Val 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  101

Phe Leu Val Asp Gly Ser Ser Ala Leu 
1               5                   


<210>  102
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  102

Phe Leu Phe Asp Gly Ser Ala Asn Leu Val 
1               5                   10  


<210>  103
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  103

Phe Leu Tyr Lys Ile Ile Asp Glu Leu 
1               5                   


<210>  104
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  104

Phe Ile Leu Asp Ser Ala Glu Thr Thr Thr Leu 
1               5                   10      


<210>  105
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  105

Ser Val Asp Val Ser Pro Pro Lys Val 
1               5                   


<210>  106
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  106

Val Ala Asp Lys Ile His Ser Val 
1               5               


<210>  107
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  107

Ile Val Asp Asp Leu Thr Ile Asn Leu 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  108

Gly Leu Leu Glu Glu Leu Val Thr Val 
1               5                   


<210>  109
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  109

Thr Leu Asp Gly Ala Ala Val Asn Gln Val 
1               5                   10  


<210>  110
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  110

Ser Val Leu Glu Lys Glu Ile Tyr Ser Ile 
1               5                   10  


<210>  111
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  111

Leu Leu Asp Pro Lys Thr Ile Phe Leu 
1               5                   


<210>  112
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  112

Tyr Thr Phe Ser Gly Asp Val Gln Leu 
1               5                   


<210>  113
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  113

Tyr Leu Met Asp Asp Phe Ser Ser Leu 
1               5                   


<210>  114
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  114

Lys Val Trp Ser Asp Val Thr Pro Leu 
1               5                   


<210>  115
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  115

Leu Leu Trp Gly His Pro Arg Val Ala Leu Ala 
1               5                   10      


<210>  116
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  116

Lys Ile Trp Glu Glu Leu Ser Val Leu Glu Val 
1               5                   10      


<210>  117
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  117

Leu Leu Ile Pro Phe Thr Ile Phe Met 
1               5                   


<210>  118
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  118

Phe Leu Ile Glu Asn Leu Leu Ala Ala 
1               5                   


<210>  119
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  119

Leu Leu Trp Gly His Pro Arg Val Ala Leu Ala 
1               5                   10      


<210>  120
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  120

Phe Leu Leu Glu Arg Glu Gln Leu Leu 
1               5                   


<210>  121
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  121

Ser Leu Ala Glu Thr Ile Phe Ile Val 
1               5                   


<210>  122
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  122

Thr Leu Leu Glu Gly Ile Ser Arg Ala 
1               5                   


<210>  123
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  123

Lys Ile Gln Glu Ile Leu Thr Gln Val 
1               5                   


<210>  124
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  124

Val Ile Phe Glu Gly Glu Pro Met Tyr Leu 
1               5                   10  


<210>  125
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  125

Ser Leu Phe Glu Ser Leu Glu Tyr Leu 
1               5                   


<210>  126
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  126

Ser Leu Leu Asn Gln Pro Lys Ala Val 
1               5                   


<210>  127
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  127

Gly Leu Ala Glu Phe Gln Glu Asn Val 
1               5                   


<210>  128
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  128

Lys Leu Leu Ala Val Ile His Glu Leu 
1               5                   


<210>  129
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  129

Thr Leu His Asp Gln Val His Leu Leu 
1               5                   


<210>  130
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  130

Thr Leu Tyr Asn Pro Glu Arg Thr Ile Thr Val 
1               5                   10      


<210>  131
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  131

Lys Leu Gln Glu Lys Ile Gln Glu Leu 
1               5                   


<210>  132
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  132

Ser Val Leu Glu Lys Glu Ile Tyr Ser Ile 
1               5                   10  


<210>  133
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  133

Arg Val Ile Asp Asp Ser Leu Val Val Gly Val 
1               5                   10      


<210>  134
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  134

Val Leu Phe Gly Glu Leu Pro Ala Leu 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  135

Gly Leu Val Asp Ile Met Val His Leu 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  136

Phe Leu Asn Ala Ile Glu Thr Ala Leu 
1               5                   


<210>  137
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  137

Ala Leu Leu Gln Ala Leu Met Glu Leu 
1               5                   


<210>  138
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  138

Ala Leu Ser Ser Ser Gln Ala Glu Val 
1               5                   


<210>  139
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  139

Ser Leu Ile Thr Gly Gln Asp Leu Leu Ser Val 
1               5                   10      


<210>  140
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  140

Gln Leu Ile Glu Lys Asn Trp Leu Leu 
1               5                   


<210>  141
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  141

Leu Leu Asp Pro Lys Thr Ile Phe Leu 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  142

Arg Leu His Asp Glu Asn Ile Leu Leu 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  143

Tyr Thr Phe Ser Gly Asp Val Gln Leu 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  144

Gly Leu Pro Ser Ala Thr Thr Thr Val 
1               5                   


<210>  145
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  145

Gly Leu Leu Pro Ser Ala Glu Ser Ile Lys Leu 
1               5                   10      


<210>  146
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  146

Lys Thr Ala Ser Ile Asn Gln Asn Val 
1               5                   


<210>  147
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  147

Ser Leu Leu Gln His Leu Ile Gly Leu 
1               5                   


<210>  148
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  148

Tyr Leu Met Asp Asp Phe Ser Ser Leu 
1               5                   


<210>  149
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  149

Leu Met Tyr Pro Tyr Ile Tyr His Val 
1               5                   


<210>  150
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  150

Lys Val Trp Ser Asp Val Thr Pro Leu 
1               5                   


<210>  151
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  151

Leu Leu Trp Gly His Pro Arg Val Ala Leu Ala 
1               5                   10      


<210>  152
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  152

Val Leu Asp Gly Lys Val Ala Val Val 
1               5                   


<210>  153
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  153

Gly Leu Leu Gly Lys Val Thr Ser Val 
1               5                   


<210>  154
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  154

Lys Met Ile Ser Ala Ile Pro Thr Leu 
1               5                   


<210>  155
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  155

Gly Leu Leu Glu Thr Thr Gly Leu Leu Ala Thr 
1               5                   10      


<210>  156
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  156

Thr Leu Asn Thr Leu Asp Ile Asn Leu 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  157

Val Ile Ile Lys Gly Leu Glu Glu Ile 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  158

Tyr Leu Glu Asp Gly Phe Ala Tyr Val 
1               5                   


<210>  159
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  159

Lys Ile Trp Glu Glu Leu Ser Val Leu Glu Val 
1               5                   10      


<210>  160
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  160

Leu Leu Ile Pro Phe Thr Ile Phe Met 
1               5                   


<210>  161
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  161

Ile Ser Leu Asp Glu Val Ala Val Ser Leu 
1               5                   10  


<210>  162
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  162

Lys Ile Ser Asp Phe Gly Leu Ala Thr Val 
1               5                   10  


<210>  163
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  163

Lys Leu Ile Gly Asn Ile His Gly Asn Glu Val 
1               5                   10      


<210>  164
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  164

Ile Leu Leu Ser Val Leu His Gln Leu 
1               5                   


<210>  165
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  165

Leu Asp Ser Glu Ala Leu Leu Thr Leu 
1               5                   


<210>  166
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  166

Val Leu Gln Glu Asn Ser Ser Asp Tyr Gln Ser Asn Leu 
1               5                   10              


<210>  167
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  167

His Leu Leu Gly Glu Gly Ala Phe Ala Gln Val 
1               5                   10      


<210>  168
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  168

Ser Leu Val Glu Asn Ile His Val Leu 
1               5                   


<210>  169
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  169

Tyr Thr Phe Ser Gly Asp Val Gln Leu 
1               5                   


<210>  170
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  170

Ser Leu Ser Glu Lys Ser Pro Glu Val 
1               5                   


<210>  171
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  171

Ala Met Phe Pro Asp Thr Ile Pro Arg Val 
1               5                   10  


<210>  172
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  172

Phe Leu Ile Glu Asn Leu Leu Ala Ala 
1               5                   


<210>  173
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  173

Phe Thr Ala Glu Phe Leu Glu Lys Val 
1               5                   


<210>  174
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  174

Ala Leu Tyr Gly Asn Val Gln Gln Val 
1               5                   


<210>  175
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  175

Leu Phe Gln Ser Arg Ile Ala Gly Val 
1               5                   


<210>  176
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  176

Ile Leu Ala Glu Glu Pro Ile Tyr Ile Arg Val 
1               5                   10      


<210>  177
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  177

Phe Leu Leu Glu Arg Glu Gln Leu Leu 
1               5                   


<210>  178
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  178

Leu Leu Leu Pro Leu Glu Leu Ser Leu Ala 
1               5                   10  


<210>  179
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  179

Ser Leu Ala Glu Thr Ile Phe Ile Val 
1               5                   


<210>  180
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  180

Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val 
1               5                   10      


<210>  181
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  181

Arg Leu Phe Glu Glu Val Leu Gly Val 
1               5                   


<210>  182
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  182

Tyr Leu Asp Glu Val Ala Phe Met Leu 
1               5                   


<210>  183
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  183

Lys Leu Ile Asp Glu Asp Glu Pro Leu Phe Leu 
1               5                   10      


<210>  184
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  184

Lys Leu Phe Glu Lys Ser Thr Gly Leu 
1               5                   


<210>  185
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  185

Ser Leu Leu Glu Val Asn Glu Ala Ser Ser Val 
1               5                   10      


<210>  186
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  186

Gly Val Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210>  187
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  187

Gly Leu Tyr Pro Val Thr Leu Val Gly Val 
1               5                   10  


<210>  188
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  188

Ala Leu Leu Ser Ser Val Ala Glu Ala 
1               5                   


<210>  189
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  189

Thr Leu Leu Glu Gly Ile Ser Arg Ala 
1               5                   


<210>  190
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  190

Ser Leu Ile Glu Glu Ser Glu Glu Leu 
1               5                   


<210>  191
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  191

Ala Leu Tyr Val Gln Ala Pro Thr Val 
1               5                   


<210>  192
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  192

Lys Leu Ile Tyr Lys Asp Leu Val Ser Val 
1               5                   10  


<210>  193
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  193

Ile Leu Gln Asp Gly Gln Phe Leu Val 
1               5                   


<210>  194
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  194

Ser Leu Leu Asp Tyr Glu Val Ser Ile 
1               5                   


<210>  195
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  195

Leu Leu Gly Asp Ser Ser Phe Phe Leu 
1               5                   


<210>  196
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  196

Val Ile Phe Glu Gly Glu Pro Met Tyr Leu 
1               5                   10  


<210>  197
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  197

Ala Leu Ser Tyr Ile Leu Pro Tyr Leu 
1               5                   


<210>  198
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  198

Phe Leu Phe Val Asp Pro Glu Leu Val 
1               5                   


<210>  199
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  199

Ser Glu Trp Gly Ser Pro His Ala Ala Val Pro 
1               5                   10      


<210>  200
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  200

Ala Leu Ser Glu Leu Glu Arg Val Leu 
1               5                   


<210>  201
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  201

Ser Leu Phe Glu Ser Leu Glu Tyr Leu 
1               5                   


<210>  202
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  202

Lys Val Leu Glu Tyr Val Ile Lys Val 
1               5                   


<210>  203
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  203

Val Leu Leu Asn Glu Ile Leu Glu Gln Val 
1               5                   10  


<210>  204
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  204

Ser Leu Leu Asn Gln Pro Lys Ala Val 
1               5                   


<210>  205
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  205

Lys Met Ser Glu Leu Gln Thr Tyr Val 
1               5                   


<210>  206
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  206

Ala Leu Leu Glu Gln Thr Gly Asp Met Ser Leu 
1               5                   10      


<210>  207
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  207

Val Ile Ile Lys Gly Leu Glu Glu Ile Thr Val 
1               5                   10      


<210>  208
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  208

Lys Gln Phe Glu Gly Thr Val Glu Ile 
1               5                   


<210>  209
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  209

Lys Leu Gln Glu Glu Ile Pro Val Leu 
1               5                   


<210>  210
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  210

Gly Leu Ala Glu Phe Gln Glu Asn Val 
1               5                   


<210>  211
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  211

Asn Val Ala Glu Ile Val Ile His Ile 
1               5                   


<210>  212
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  212

Ala Leu Ala Gly Ile Val Thr Asn Val 
1               5                   


<210>  213
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  213

Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
1               5                   10          


<210>  214
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  214

Val Leu Met Gln Asp Ser Arg Leu Tyr Leu 
1               5                   10  


<210>  215
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  215

Lys Val Leu Glu His Val Val Arg Val 
1               5                   


<210>  216
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  216

Leu Leu Trp Gly Asn Leu Pro Glu Ile 
1               5                   


<210>  217
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  217

Ser Leu Met Glu Lys Asn Gln Ser Leu 
1               5                   


<210>  218
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  218

Lys Leu Leu Ala Val Ile His Glu Leu 
1               5                   


<210>  219
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  219

Ala Leu Gly Asp Lys Phe Leu Leu Arg Val 
1               5                   10  


<210>  220
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  220

Phe Leu Met Lys Asn Ser Asp Leu Tyr Gly Ala 
1               5                   10      


<210>  221
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  221

Lys Leu Ile Asp His Gln Gly Leu Tyr Leu 
1               5                   10  


<210>  222
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  222

Gly Pro Gly Ile Phe Pro Pro Pro Pro Pro Gln Pro 
1               5                   10          


<210>  223
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  223

Ala Leu Asn Glu Ser Leu Val Glu Cys 
1               5                   


<210>  224
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  224

Gly Leu Ala Ala Leu Ala Val His Leu 
1               5                   


<210>  225
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  225

Leu Leu Leu Glu Ala Val Trp His Leu 
1               5                   


<210>  226
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  226

Ser Ile Ile Glu Tyr Leu Pro Thr Leu 
1               5                   


<210>  227
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  227

Thr Leu His Asp Gln Val His Leu Leu 
1               5                   


<210>  228
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  228

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  229
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  229

Phe Leu Leu Asp Lys Pro Gln Asp Leu Ser Ile 
1               5                   10      


<210>  230
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  230

Tyr Leu Leu Asp Met Pro Leu Trp Tyr Leu 
1               5                   10  


<210>  231
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  231

Gly Leu Leu Asp Cys Pro Ile Phe Leu 
1               5                   


<210>  232
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  232

Val Leu Ile Glu Tyr Asn Phe Ser Ile 
1               5                   


<210>  233
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  233

Thr Leu Tyr Asn Pro Glu Arg Thr Ile Thr Val 
1               5                   10      


<210>  234
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  234

Ala Val Pro Pro Pro Pro Ser Ser Val 
1               5                   


<210>  235
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  235

Lys Leu Gln Glu Glu Leu Asn Lys Val 
1               5                   


<210>  236
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  236

Lys Leu Met Asp Pro Gly Ser Leu Pro Pro Leu 
1               5                   10      


<210>  237
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  237

Ala Leu Ile Val Ser Leu Pro Tyr Leu 
1               5                   


<210>  238
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  238

Phe Leu Leu Asp Gly Ser Ala Asn Val 
1               5                   


<210>  239
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  239

Ala Leu Asp Pro Ser Gly Asn Gln Leu Ile 
1               5                   10  


<210>  240
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  240

Ile Leu Ile Lys His Leu Val Lys Val 
1               5                   


<210>  241
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  241

Val Leu Leu Asp Thr Ile Leu Gln Leu 
1               5                   


<210>  242
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  242

His Leu Ile Ala Glu Ile His Thr Ala 
1               5                   


<210>  243
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  243

Ser Met Asn Gly Gly Val Phe Ala Val 
1               5                   


<210>  244
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Leu Ala Glu Lys Leu Leu Gln Ala 
1               5                   


<210>  245
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  245

Tyr Met Leu Asp Ile Phe His Glu Val 
1               5                   


<210>  246
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  246

Ala Leu Trp Leu Pro Thr Asp Ser Ala Thr Val 
1               5                   10      


<210>  247
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  247

Gly Leu Ala Ser Arg Ile Leu Asp Ala 
1               5                   


<210>  248
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  248

Ala Leu Ser Val Leu Arg Leu Ala Leu 
1               5                   


<210>  249
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  249

Ser Tyr Val Lys Val Leu His His Leu 
1               5                   


<210>  250
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  250

Val Tyr Leu Pro Lys Ile Pro Ser Trp 
1               5                   


<210>  251
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  251

Asn Tyr Glu Asp His Phe Pro Leu Leu 
1               5                   


<210>  252
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  252

Val Tyr Ile Ala Glu Leu Glu Lys Ile 
1               5                   


<210>  253
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  253

Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe 
1               5                   10          


<210>  254
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  254

Val Leu Ser Pro Phe Ile Leu Thr Leu 
1               5                   


<210>  255
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  255

His Leu Leu Glu Gly Ser Val Gly Val 
1               5                   


<210>  256
<211>  607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPREmut1

<400>  256
cagtctgacg tacgcgtaat caacctctgg attacaaaat ttgtgaaaga ttgactggta       60

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc      120

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt      180

ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg      240

ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt      300

tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct      360

ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt      420

cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct      480

acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc      540

ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct      600

ccccgcc                                                                607


<210>  257
<211>  581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPREmut2

<400>  257
gagcatctta ccgccattta tacccatatt tgttctgttt ttcttgattt gggtatacat       60

ttaaatgtta ataaaacaaa atggtggggc aatcatttac attttttggg atatgtaatt      120

actagttcag gtgtattgcc acaagacaaa cttgttaaga aactttcccg ttatttacgc      180

tctgttcctg ttaatcaacc tctggattac aaaatttgtg aaagattgac tgatattctt      240

aactttgttg ctccttttac gctgtgtgga tttgctgctt tattgcctct gtatcttgct      300

attgcttccc gtacggcttt cgttttctcc tccttgtata aatcctggtt gctgtctctt      360

tttgaggagt tgtggcccgt tgtccgtcaa cgtggcgtgg tgtgctctgt gtttgctgac      420

gcaaccccca ctggctgggg cattgccacc acctgtcaac tcctttctgg gactttcgct      480

ttccccctcc cgatcgccac ggcagaactc atcgccgcct gccttgcccg ctgctggaca      540

ggggctaggt tgctgggcac tgataattcc gtggtgttgt c                          581


<210>  258
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  259
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Cys 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  260
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha stalk

<400>  260

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45          


<210>  261
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha Ig-like domain-2

<400>  261

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Cys Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala 
        


<210>  262
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m2CD8alpha

<400>  262

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Cys 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Ser Val Val Asp Phe Leu Pro Thr Thr 
    130                 135                 140                 


Ala Gln Pro Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu 
145                 150                 155                 160 


Pro Arg Pro Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Tyr Ile 
                165                 170                 175     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            180                 185                 190         


Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys 
        195                 200                 205             


Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg 
    210                 215                 220                 


Tyr Val 
225     


<210>  263
<211>  367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MSCV promoter

<400>  263
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcact                                                                367


<210>  264
<211>  607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE

<400>  264
cagtctgacg tacgcgtaat caacctctgg attacaaaat ttgtgaaaga ttgactggta       60

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc      120

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt      180

ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg      240

ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt      300

tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct      360

ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aagctgacgt      420

cctttccatg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct      480

acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc      540

ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct      600

ccccgcc                                                                607


<210>  265
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin consensus


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  265

Arg Xaa Xaa Arg 
1               


<210>  266
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  266

Ser Gly Ser Gly 
1               


<210>  267
<211>  4320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8b3.CD8a.TCR.WPREmut2 construct nucleotide sequence

<400>  267
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg cgcccgagac tgtggcttct      420

gctcgccgcg caactgactg tcctgcacgg aaacagcgtg ctgcagcaga caccggccta      480

catcaaagtg cagaccaaca agatggtcat gctgtcctgc gaggccaaga tttccctctc      540

caacatgcgg atctattggt tgcggcagag acaggcgcct tcctcggact cccaccatga      600

gttcttggcc ctgtgggact ccgccaaggg aactattcac ggcgaagaag tggaacagga      660

gaagatcgcc gtgtttcgcg atgcctcccg ctttatactg aatctgacct ccgtgaagcc      720

cgaagatagc gggatctact tttgcatgat tgtgggctca cccgaactga ccttcgggaa      780

gggcactcag ctgagcgtgg tggacttcct ccccactacc gcccaaccca ctaagaagtc      840

aaccctgaag aagcgggttt gcagactccc acggccggaa acgcagaagg gtccgctgtg      900

ttccccgatc accctggggc tccttgtggc tggagtgctg gtccttctgg tgtcccttgg      960

cgtcgccatt cacctctgct gccggagaag gagggccaga ctgaggttca tgaagcagtt     1020

ctacaagcgg gccaagagat ctggcagcgg cgccaccaat ttcagcctgc tgaaacaggc     1080

cggcgacgtg gaagagaacc ctggccccat ggcgcttccc gtgaccgcac tcctgttgcc     1140

ccttgccctg ctgttgcacg ccgcacgacc ttcccaattc cgggtgtccc ctctggatcg     1200

cacctggaac ctcggggaaa cggtggagct caagtgtcaa gtcctcctgt cgaacccgac     1260

cagcggatgc agctggctgt tccagccgag aggagctgcc gcctcaccca ccttcctcct     1320

gtacttgagc cagaacaagc cgaaggccgc tgagggtctg gacacccagc gcttctcggg     1380

caaacggctg ggagacactt ttgtgctgac tctctccgac ttccggcggg agaacgaggg     1440

ctactacttc tgctctgcgc tctccaattc aatcatgtac ttctcacact tcgtgccggt     1500

gttcctgcct gccaagccca ccactactcc ggcacccaga cctccaactc ccgctcccac     1560

catcgcgtcc caaccccttt cgctgcgccc tgaagcgtgt cggcctgctg ctggaggagc     1620

cgtgcatacc cgcggtctgg acttcgcgtg cgacatctac atttgggccc ctttggctgg     1680

cacctgtgga gtgctgctcc tgtcccttgt gatcaccctg tactgcaacc accggaatag     1740

gcggagagtc tgcaagtgtc cgcggcctgt cgtgaagtca ggagataagc cgagcctgtc     1800

cgcacgctac gtgcgggcca agagatctgg cagcggcgag ggcagaggca gcctgctgac     1860

ctgcggcgac gtggaggaga accccggccc catggactct tggaccttct gctgcgtgag     1920

cctgtgcatc ctggtggcca agcacacaga cgccggcgtg atccagtccc ctaggcacga     1980

ggtgaccgag atgggccagg aggtgacact gcgctgtaag ccaatctctg gccacaacag     2040

cctgttttgg tatagggaga ccatgatgcg cggcctggag ctgctgatct acttcaataa     2100

caatgtgccc atcgacgatt ccggcatgcc tgaggatcgg ttttctgcca agatgcccaa     2160

tgccagcttc tccacactga agatccagcc tagcgagcca agagactccg ccgtgtattt     2220

ttgcgcctct agcccaggca gcaccgatac acagtacttc ggaccaggaa ccaggctgac     2280

agtgctggag gacctgaaga acgtgttccc ccctgaggtg gccgtgtttg agccctctga     2340

ggccgagatc agccacaccc agaaggccac cctggtgtgc ctggcaaccg gcttctatcc     2400

tgatcacgtg gagctgtcct ggtgggtgaa cggcaaggag gtgcacagcg gcgtgtccac     2460

agacccacag cccctgaagg agcagccagc cctgaatgat agccggtatt gcctgtcctc     2520

tcggctgaga gtgtccgcca ccttttggca gaacccccgg aatcacttca gatgtcaggt     2580

gcagttttac ggcctgtccg agaacgatga gtggacccag gaccgggcca agcctgtgac     2640

acagatcgtg tctgccgagg catggggaag agcagactgt ggcttcacct ctgagagcta     2700

ccagcagggc gtgctgagcg ccaccatcct gtatgagatc ctgctgggca aggccacact     2760

gtacgccgtc ctggtctccg ctctggtgct gatggcaatg gtcaaaagaa aagatagtcg     2820

gggacgggcc aagagatctg gcagcggcca gtgcaccaac tacgccctgc tgaagctggc     2880

cggcgacgtg gagagcaacc ccggccccat ggagaagaat cccctggctg cccccctgct     2940

gatcctgtgg tttcacctgg actgcgtgtc ctctatcctg aatgtggaac agagcccaca     3000

gagcctgcac gtgcaggagg gcgactccac caacttcaca tgctcttttc ctagctccaa     3060

cttctacgcc ctgcactggt acagaaagga gaccgcaaag tccccagagg ccctgttcgt     3120

gatgacactg aacggcgatg agaagaagaa gggccgcatc agcgccaccc tgaatacaaa     3180

ggagggctac tcctatctgt acatcaaggg ctcccagcct gaggactctg ccacctatct     3240

gtgcgccctg tacaacaata acgatatgcg gtttggcgcc ggcaccagac tgacagtgaa     3300

gccaaacatc cagaatccag accccgccgt gtatcagctg cgggacagca agtctagcga     3360

taagagcgtg tgcctgttca ccgactttga ttctcagaca aacgtgagcc agtccaagga     3420

cagcgacgtg tacatcaccg acaagacagt gctggatatg agaagcatgg acttcaagtc     3480

taacagcgcc gtggcctggt ccaataagtc tgatttcgcc tgcgccaatg cctttaataa     3540

ctccatcatc cccgaggata ccttctttcc ttctccagag tcctcttgtg acgtgaagct     3600

ggtggagaag tctttcgaga ccgatacaaa cctgaatttt cagaacctga gcgtgatcgg     3660

cttcaggatc ctgctgctga aggtggccgg ctttaatctg ctgatgaccc tgaggctgtg     3720

gagctcctga accggtccgg agcatcttac cgccatttat acccatattt gttctgtttt     3780

tcttgatttg ggtatacatt taaatgttaa taaaacaaaa tggtggggca atcatttaca     3840

ttttttggga tatgtaatta ctagttcagg tgtattgcca caagacaaac ttgttaagaa     3900

actttcccgt tatttacgct ctgttcctgt taatcaacct ctggattaca aaatttgtga     3960

aagattgact gatattctta actttgttgc tccttttacg ctgtgtggat ttgctgcttt     4020

attgcctctg tatcttgcta ttgcttcccg tacggctttc gttttctcct ccttgtataa     4080

atcctggttg ctgtctcttt ttgaggagtt gtggcccgtt gtccgtcaac gtggcgtggt     4140

gtgctctgtg tttgctgacg caacccccac tggctggggc attgccacca cctgtcaact     4200

cctttctggg actttcgctt tccccctccc gatcgccacg gcagaactca tcgccgcctg     4260

ccttgcccgc tgctggacag gggctaggtt gctgggcact gataattccg tggtgttgtc     4320


<210>  268
<211>  1110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8b3.CD8a.TCR.WPREmut2 amino acid sequence

<400>  268

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe 
        195                 200                 205             


Tyr Lys Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
    210                 215                 220                 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
225                 230                 235                 240 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
                245                 250                 255     


Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu 
            260                 265                 270         


Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr 
        275                 280                 285             


Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro 
    290                 295                 300                 


Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val 
                325                 330                 335     


Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys 
            340                 345                 350         


Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val 
        355                 360                 365             


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    370                 375                 380                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
385                 390                 395                 400 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                405                 410                 415     


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
            420                 425                 430         


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg 
        435                 440                 445             


Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys 
    450                 455                 460                 


Pro Ser Leu Ser Ala Arg Tyr Val Arg Ala Lys Arg Ser Gly Ser Gly 
465                 470                 475                 480 


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
                485                 490                 495     


Gly Pro Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu 
            500                 505                 510         


Val Ala Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu 
        515                 520                 525             


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
    530                 535                 540                 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu 
545                 550                 555                 560 


Glu Leu Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly 
                565                 570                 575     


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
            580                 585                 590         


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
        595                 600                 605             


Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
    610                 615                 620                 


Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
625                 630                 635                 640 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
                645                 650                 655     


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
            660                 665                 670         


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
        675                 680                 685             


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
    690                 695                 700                 


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
705                 710                 715                 720 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
                725                 730                 735     


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
            740                 745                 750         


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
        755                 760                 765             


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
    770                 775                 780                 


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
785                 790                 795                 800 


Met Val Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg Ser Gly Ser 
                805                 810                 815     


Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu 
            820                 825                 830         


Ser Asn Pro Gly Pro Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu 
        835                 840                 845             


Ile Leu Trp Phe His Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu 
    850                 855                 860                 


Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe 
865                 870                 875                 880 


Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg 
                885                 890                 895     


Lys Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn 
            900                 905                 910         


Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys 
        915                 920                 925             


Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser 
    930                 935                 940                 


Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly 
945                 950                 955                 960 


Ala Gly Thr Arg Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro 
                965                 970                 975     


Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys 
            980                 985                 990         


Leu Phe Thr Asp Phe Asp Ser Gln  Thr Asn Val Ser Gln  Ser Lys Asp 
        995                 1000                 1005             


Ser Asp  Val Tyr Ile Thr Asp  Lys Thr Val Leu Asp  Met Arg Ser 
    1010                 1015                 1020             


Met Asp  Phe Lys Ser Asn Ser  Ala Val Ala Trp Ser  Asn Lys Ser 
    1025                 1030                 1035             


Asp Phe  Ala Cys Ala Asn Ala  Phe Asn Asn Ser Ile  Ile Pro Glu 
    1040                 1045                 1050             


Asp Thr  Phe Phe Pro Ser Pro  Glu Ser Ser Cys Asp  Val Lys Leu 
    1055                 1060                 1065             


Val Glu  Lys Ser Phe Glu Thr  Asp Thr Asn Leu Asn  Phe Gln Asn 
    1070                 1075                 1080             


Leu Ser  Val Ile Gly Phe Arg  Ile Leu Leu Leu Lys  Val Ala Gly 
    1085                 1090                 1095             


Phe Asn  Leu Leu Met Thr Leu  Arg Leu Trp Ser Ser  
    1100                 1105                 1110 


<210>  269
<211>  4314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8b1(S19).CD8a.TCR.WPREmut2 construct nucleotide sequence

<400>  269
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gaattcggcc tgagctggct      420

gttcctggtg gccatcctga agggcgtgca gtgcctgcag cagacaccgg cctacatcaa      480

agtgcagacc aacaagatgg tcatgctgtc ctgcgaggcc aagatttccc tctccaacat      540

gcggatctat tggttgcggc agagacaggc gccttcctcg gactcccacc atgagttctt      600

ggccctgtgg gactccgcca agggaactat tcacggcgaa gaagtggaac aggagaagat      660

cgccgtgttt cgcgatgcct cccgctttat actgaatctg acctccgtga agcccgaaga      720

tagcgggatc tacttttgca tgattgtggg ctcacccgaa ctgaccttcg ggaagggcac      780

tcagctgagc gtggtggact tcctccccac taccgcccaa cccactaaga agtcaaccct      840

gaagaagcgg gtttgcagac tcccacggcc ggaaacgcag aagggtccgc tgtgttcccc      900

gatcaccctg gggctccttg tggctggagt gctggtcctt ctggtgtccc ttggcgtcgc      960

cattcacctc tgctgccgga gaaggagggc cagactgagg ttcatgaagc agttctacaa     1020

gcgggccaag agatctggca gcggcgccac caatttcagc ctgctgaaac aggccggcga     1080

cgtggaagag aaccctggcc ccatggcgct tcccgtgacc gcactcctgt tgccccttgc     1140

cctgctgttg cacgccgcac gaccttccca attccgggtg tcccctctgg atcgcacctg     1200

gaacctcggg gaaacggtgg agctcaagtg tcaagtcctc ctgtcgaacc cgaccagcgg     1260

atgcagctgg ctgttccagc cgagaggagc tgccgcctca cccaccttcc tcctgtactt     1320

gagccagaac aagccgaagg ccgctgaggg tctggacacc cagcgcttct cgggcaaacg     1380

gctgggagac acttttgtgc tgactctctc cgacttccgg cgggagaacg agggctacta     1440

cttctgctct gcgctctcca attcaatcat gtacttctca cacttcgtgc cggtgttcct     1500

gcctgccaag cccaccacta ctccggcacc cagacctcca actcccgctc ccaccatcgc     1560

gtcccaaccc ctttcgctgc gccctgaagc gtgtcggcct gctgctggag gagccgtgca     1620

tacccgcggt ctggacttcg cgtgcgacat ctacatttgg gcccctttgg ctggcacctg     1680

tggagtgctg ctcctgtccc ttgtgatcac cctgtactgc aaccaccgga ataggcggag     1740

agtctgcaag tgtccgcggc ctgtcgtgaa gtcaggagat aagccgagcc tgtccgcacg     1800

ctacgtgcgg gccaagagat ctggcagcgg cgagggcaga ggcagcctgc tgacctgcgg     1860

cgacgtggag gagaaccccg gccccatgga ctcttggacc ttctgctgcg tgagcctgtg     1920

catcctggtg gccaagcaca cagacgccgg cgtgatccag tcccctaggc acgaggtgac     1980

cgagatgggc caggaggtga cactgcgctg taagccaatc tctggccaca acagcctgtt     2040

ttggtatagg gagaccatga tgcgcggcct ggagctgctg atctacttca ataacaatgt     2100

gcccatcgac gattccggca tgcctgagga tcggttttct gccaagatgc ccaatgccag     2160

cttctccaca ctgaagatcc agcctagcga gccaagagac tccgccgtgt atttttgcgc     2220

ctctagccca ggcagcaccg atacacagta cttcggacca ggaaccaggc tgacagtgct     2280

ggaggacctg aagaacgtgt tcccccctga ggtggccgtg tttgagccct ctgaggccga     2340

gatcagccac acccagaagg ccaccctggt gtgcctggca accggcttct atcctgatca     2400

cgtggagctg tcctggtggg tgaacggcaa ggaggtgcac agcggcgtgt ccacagaccc     2460

acagcccctg aaggagcagc cagccctgaa tgatagccgg tattgcctgt cctctcggct     2520

gagagtgtcc gccacctttt ggcagaaccc ccggaatcac ttcagatgtc aggtgcagtt     2580

ttacggcctg tccgagaacg atgagtggac ccaggaccgg gccaagcctg tgacacagat     2640

cgtgtctgcc gaggcatggg gaagagcaga ctgtggcttc acctctgaga gctaccagca     2700

gggcgtgctg agcgccacca tcctgtatga gatcctgctg ggcaaggcca cactgtacgc     2760

cgtcctggtc tccgctctgg tgctgatggc aatggtcaaa agaaaagata gtcggggacg     2820

ggccaagaga tctggcagcg gccagtgcac caactacgcc ctgctgaagc tggccggcga     2880

cgtggagagc aaccccggcc ccatggagaa gaatcccctg gctgcccccc tgctgatcct     2940

gtggtttcac ctggactgcg tgtcctctat cctgaatgtg gaacagagcc cacagagcct     3000

gcacgtgcag gagggcgact ccaccaactt cacatgctct tttcctagct ccaacttcta     3060

cgccctgcac tggtacagaa aggagaccgc aaagtcccca gaggccctgt tcgtgatgac     3120

actgaacggc gatgagaaga agaagggccg catcagcgcc accctgaata caaaggaggg     3180

ctactcctat ctgtacatca agggctccca gcctgaggac tctgccacct atctgtgcgc     3240

cctgtacaac aataacgata tgcggtttgg cgccggcacc agactgacag tgaagccaaa     3300

catccagaat ccagaccccg ccgtgtatca gctgcgggac agcaagtcta gcgataagag     3360

cgtgtgcctg ttcaccgact ttgattctca gacaaacgtg agccagtcca aggacagcga     3420

cgtgtacatc accgacaaga cagtgctgga tatgagaagc atggacttca agtctaacag     3480

cgccgtggcc tggtccaata agtctgattt cgcctgcgcc aatgccttta ataactccat     3540

catccccgag gataccttct ttccttctcc agagtcctct tgtgacgtga agctggtgga     3600

gaagtctttc gagaccgata caaacctgaa ttttcagaac ctgagcgtga tcggcttcag     3660

gatcctgctg ctgaaggtgg ccggctttaa tctgctgatg accctgaggc tgtggagctc     3720

ctgaaccggt ccggagcatc ttaccgccat ttatacccat atttgttctg tttttcttga     3780

tttgggtata catttaaatg ttaataaaac aaaatggtgg ggcaatcatt tacatttttt     3840

gggatatgta attactagtt caggtgtatt gccacaagac aaacttgtta agaaactttc     3900

ccgttattta cgctctgttc ctgttaatca acctctggat tacaaaattt gtgaaagatt     3960

gactgatatt cttaactttg ttgctccttt tacgctgtgt ggatttgctg ctttattgcc     4020

tctgtatctt gctattgctt cccgtacggc tttcgttttc tcctccttgt ataaatcctg     4080

gttgctgtct ctttttgagg agttgtggcc cgttgtccgt caacgtggcg tggtgtgctc     4140

tgtgtttgct gacgcaaccc ccactggctg gggcattgcc accacctgtc aactcctttc     4200

tgggactttc gctttccccc tcccgatcgc cacggcagaa ctcatcgccg cctgccttgc     4260

ccgctgctgg acaggggcta ggttgctggg cactgataat tccgtggtgt tgtc           4314


<210>  270
<211>  1108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8b1(S19).CD8a.TCR.WPREmut2 amino acid sequence

<400>  270

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn 
            20                  25                  30          


Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met 
        35                  40                  45              


Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His 
    50                  55                  60                  


His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly 
65                  70                  75                  80  


Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg 
                85                  90                  95      


Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr 
            100                 105                 110         


Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys 
    130                 135                 140                 


Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr 
145                 150                 155                 160 


Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala 
                165                 170                 175     


Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys 
            180                 185                 190         


Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe Tyr Lys 
        195                 200                 205             


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
    210                 215                 220                 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
225                 230                 235                 240 


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
                245                 250                 255     


Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
            260                 265                 270         


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
        275                 280                 285             


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
    290                 295                 300                 


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
305                 310                 315                 320 


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
                325                 330                 335     


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
            340                 345                 350         


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
        355                 360                 365             


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    370                 375                 380                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
385                 390                 395                 400 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                405                 410                 415     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            420                 425                 430         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg 
        435                 440                 445             


Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser 
    450                 455                 460                 


Leu Ser Ala Arg Tyr Val Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly 
465                 470                 475                 480 


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
                485                 490                 495     


Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
            500                 505                 510         


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        515                 520                 525             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    530                 535                 540                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu 
545                 550                 555                 560 


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
                565                 570                 575     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
            580                 585                 590         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        595                 600                 605             


Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
    610                 615                 620                 


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
625                 630                 635                 640 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
                645                 650                 655     


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
            660                 665                 670         


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
        675                 680                 685             


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
    690                 695                 700                 


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
705                 710                 715                 720 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
                725                 730                 735     


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
            740                 745                 750         


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
        755                 760                 765             


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
    770                 775                 780                 


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
785                 790                 795                 800 


Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg Ser Gly Ser Gly Gln 
                805                 810                 815     


Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
            820                 825                 830         


Pro Gly Pro Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu 
        835                 840                 845             


Trp Phe His Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser 
    850                 855                 860                 


Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys 
865                 870                 875                 880 


Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu 
                885                 890                 895     


Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp 
            900                 905                 910         


Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly 
        915                 920                 925             


Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr 
    930                 935                 940                 


Tyr Leu Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly 
945                 950                 955                 960 


Thr Arg Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val 
                965                 970                 975     


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
            980                 985                 990         


Thr Asp Phe Asp Ser Gln Thr Asn  Val Ser Gln Ser Lys  Asp Ser Asp 
        995                 1000                 1005             


Val Tyr  Ile Thr Asp Lys Thr  Val Leu Asp Met Arg  Ser Met Asp 
    1010                 1015                 1020             


Phe Lys  Ser Asn Ser Ala Val  Ala Trp Ser Asn Lys  Ser Asp Phe 
    1025                 1030                 1035             


Ala Cys  Ala Asn Ala Phe Asn  Asn Ser Ile Ile Pro  Glu Asp Thr 
    1040                 1045                 1050             


Phe Phe  Pro Ser Pro Glu Ser  Ser Cys Asp Val Lys  Leu Val Glu 
    1055                 1060                 1065             


Lys Ser  Phe Glu Thr Asp Thr  Asn Leu Asn Phe Gln  Asn Leu Ser 
    1070                 1075                 1080             


Val Ile  Gly Phe Arg Ile Leu  Leu Leu Lys Val Ala  Gly Phe Asn 
    1085                 1090                 1095             


Leu Leu  Met Thr Leu Arg Leu  Trp Ser Ser 
    1100                 1105             


<210>  271
<211>  4428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8b4.CD8a.TCR.WPREmut2 construct nucleotide sequence

<400>  271
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg cgcccgagac tgtggcttct      420

gctcgccgcg caactgactg tcctgcacgg aaacagcgtg ctgcagcaga caccggccta      480

catcaaagtg cagaccaaca agatggtcat gctgtcctgc gaggccaaga tttccctctc      540

caacatgcgg atctattggt tgcggcagag acaggcgcct tcctcggact cccaccatga      600

gttcttggcc ctgtgggact ccgccaaggg aactattcac ggcgaagaag tggaacagga      660

gaagatcgcc gtgtttcgcg atgcctcccg ctttatactg aatctgacct ccgtgaagcc      720

cgaagatagc gggatctact tttgcatgat tgtgggctca cccgaactga ccttcgggaa      780

gggcactcag ctgagcgtgg tggacttcct ccccactacc gcccaaccca ctaagaagtc      840

aaccctgaag aagcgggttt gcagactccc acggccggaa acgcagaagg gtccgctgtg      900

ttccccgatc accctggggc tccttgtggc tggagtgctg gtccttctgg tgtcccttgg      960

cgtcgccatt cacctctgct gccggagaag gagggccaga ctgaggttca tgaagcagaa     1020

gttcaacata gtctgcctga agatttccgg gttcactact tgctgctgct tccaaatact     1080

ccagatttca cgagaatatg ggttcggtgt gttgctccaa aaagacatcg gtcaacgggc     1140

caagagatct ggcagcggcg ccaccaattt cagcctgctg aaacaggccg gcgacgtgga     1200

agagaaccct ggccccatgg cgcttcccgt gaccgcactc ctgttgcccc ttgccctgct     1260

gttgcacgcc gcacgacctt cccaattccg ggtgtcccct ctggatcgca cctggaacct     1320

cggggaaacg gtggagctca agtgtcaagt cctcctgtcg aacccgacca gcggatgcag     1380

ctggctgttc cagccgagag gagctgccgc ctcacccacc ttcctcctgt acttgagcca     1440

gaacaagccg aaggccgctg agggtctgga cacccagcgc ttctcgggca aacggctggg     1500

agacactttt gtgctgactc tctccgactt ccggcgggag aacgagggct actacttctg     1560

ctctgcgctc tccaattcaa tcatgtactt ctcacacttc gtgccggtgt tcctgcctgc     1620

caagcccacc actactccgg cacccagacc tccaactccc gctcccacca tcgcgtccca     1680

acccctttcg ctgcgccctg aagcgtgtcg gcctgctgct ggaggagccg tgcatacccg     1740

cggtctggac ttcgcgtgcg acatctacat ttgggcccct ttggctggca cctgtggagt     1800

gctgctcctg tcccttgtga tcaccctgta ctgcaaccac cggaataggc ggagagtctg     1860

caagtgtccg cggcctgtcg tgaagtcagg agataagccg agcctgtccg cacgctacgt     1920

gcgggccaag agatctggca gcggcgaggg cagaggcagc ctgctgacct gcggcgacgt     1980

ggaggagaac cccggcccca tggactcttg gaccttctgc tgcgtgagcc tgtgcatcct     2040

ggtggccaag cacacagacg ccggcgtgat ccagtcccct aggcacgagg tgaccgagat     2100

gggccaggag gtgacactgc gctgtaagcc aatctctggc cacaacagcc tgttttggta     2160

tagggagacc atgatgcgcg gcctggagct gctgatctac ttcaataaca atgtgcccat     2220

cgacgattcc ggcatgcctg aggatcggtt ttctgccaag atgcccaatg ccagcttctc     2280

cacactgaag atccagccta gcgagccaag agactccgcc gtgtattttt gcgcctctag     2340

cccaggcagc accgatacac agtacttcgg accaggaacc aggctgacag tgctggagga     2400

cctgaagaac gtgttccccc ctgaggtggc cgtgtttgag ccctctgagg ccgagatcag     2460

ccacacccag aaggccaccc tggtgtgcct ggcaaccggc ttctatcctg atcacgtgga     2520

gctgtcctgg tgggtgaacg gcaaggaggt gcacagcggc gtgtccacag acccacagcc     2580

cctgaaggag cagccagccc tgaatgatag ccggtattgc ctgtcctctc ggctgagagt     2640

gtccgccacc ttttggcaga acccccggaa tcacttcaga tgtcaggtgc agttttacgg     2700

cctgtccgag aacgatgagt ggacccagga ccgggccaag cctgtgacac agatcgtgtc     2760

tgccgaggca tggggaagag cagactgtgg cttcacctct gagagctacc agcagggcgt     2820

gctgagcgcc accatcctgt atgagatcct gctgggcaag gccacactgt acgccgtcct     2880

ggtctccgct ctggtgctga tggcaatggt caaaagaaaa gatagtcggg gacgggccaa     2940

gagatctggc agcggccagt gcaccaacta cgccctgctg aagctggccg gcgacgtgga     3000

gagcaacccc ggccccatgg agaagaatcc cctggctgcc cccctgctga tcctgtggtt     3060

tcacctggac tgcgtgtcct ctatcctgaa tgtggaacag agcccacaga gcctgcacgt     3120

gcaggagggc gactccacca acttcacatg ctcttttcct agctccaact tctacgccct     3180

gcactggtac agaaaggaga ccgcaaagtc cccagaggcc ctgttcgtga tgacactgaa     3240

cggcgatgag aagaagaagg gccgcatcag cgccaccctg aatacaaagg agggctactc     3300

ctatctgtac atcaagggct cccagcctga ggactctgcc acctatctgt gcgccctgta     3360

caacaataac gatatgcggt ttggcgccgg caccagactg acagtgaagc caaacatcca     3420

gaatccagac cccgccgtgt atcagctgcg ggacagcaag tctagcgata agagcgtgtg     3480

cctgttcacc gactttgatt ctcagacaaa cgtgagccag tccaaggaca gcgacgtgta     3540

catcaccgac aagacagtgc tggatatgag aagcatggac ttcaagtcta acagcgccgt     3600

ggcctggtcc aataagtctg atttcgcctg cgccaatgcc tttaataact ccatcatccc     3660

cgaggatacc ttctttcctt ctccagagtc ctcttgtgac gtgaagctgg tggagaagtc     3720

tttcgagacc gatacaaacc tgaattttca gaacctgagc gtgatcggct tcaggatcct     3780

gctgctgaag gtggccggct ttaatctgct gatgaccctg aggctgtgga gctcctgaac     3840

cggtccggag catcttaccg ccatttatac ccatatttgt tctgtttttc ttgatttggg     3900

tatacattta aatgttaata aaacaaaatg gtggggcaat catttacatt ttttgggata     3960

tgtaattact agttcaggtg tattgccaca agacaaactt gttaagaaac tttcccgtta     4020

tttacgctct gttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactga     4080

tattcttaac tttgttgctc cttttacgct gtgtggattt gctgctttat tgcctctgta     4140

tcttgctatt gcttcccgta cggctttcgt tttctcctcc ttgtataaat cctggttgct     4200

gtctcttttt gaggagttgt ggcccgttgt ccgtcaacgt ggcgtggtgt gctctgtgtt     4260

tgctgacgca acccccactg gctggggcat tgccaccacc tgtcaactcc tttctgggac     4320

tttcgctttc cccctcccga tcgccacggc agaactcatc gccgcctgcc ttgcccgctg     4380

ctggacaggg gctaggttgc tgggcactga taattccgtg gtgttgtc                  4428


<210>  272
<211>  1146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8b4.CD8a.TCR.WPREmut2 amino acid sequence

<400>  272

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Lys 
        195                 200                 205             


Phe Asn Ile Val Cys Leu Lys Ile Ser Gly Phe Thr Thr Cys Cys Cys 
    210                 215                 220                 


Phe Gln Ile Leu Gln Ile Ser Arg Glu Tyr Gly Phe Gly Val Leu Leu 
225                 230                 235                 240 


Gln Lys Asp Ile Gly Gln Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr 
                245                 250                 255     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            260                 265                 270         


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
        275                 280                 285             


Leu His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg 
    290                 295                 300                 


Thr Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu 
305                 310                 315                 320 


Ser Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala 
                325                 330                 335     


Ala Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys 
            340                 345                 350         


Ala Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly 
        355                 360                 365             


Asp Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly 
    370                 375                 380                 


Tyr Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His 
385                 390                 395                 400 


Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                405                 410                 415     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            420                 425                 430         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        435                 440                 445             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    450                 455                 460                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
465                 470                 475                 480 


His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys 
                485                 490                 495     


Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val Arg Ala Lys Arg 
            500                 505                 510         


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
        515                 520                 525             


Glu Glu Asn Pro Gly Pro Met Asp Ser Trp Thr Phe Cys Cys Val Ser 
    530                 535                 540                 


Leu Cys Ile Leu Val Ala Lys His Thr Asp Ala Gly Val Ile Gln Ser 
545                 550                 555                 560 


Pro Arg His Glu Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys 
                565                 570                 575     


Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met 
            580                 585                 590         


Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile 
        595                 600                 605             


Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn 
    610                 615                 620                 


Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser 
625                 630                 635                 640 


Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr 
                645                 650                 655     


Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val 
            660                 665                 670         


Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser 
        675                 680                 685             


His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro 
    690                 695                 700                 


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
705                 710                 715                 720 


Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn 
                725                 730                 735     


Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe 
            740                 745                 750         


Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly 
        755                 760                 765             


Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr 
    770                 775                 780                 


Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr 
785                 790                 795                 800 


Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu 
                805                 810                 815     


Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu 
            820                 825                 830         


Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys 
        835                 840                 845             


Arg Ser Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala 
    850                 855                 860                 


Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Lys Asn Pro Leu Ala 
865                 870                 875                 880 


Ala Pro Leu Leu Ile Leu Trp Phe His Leu Asp Cys Val Ser Ser Ile 
                885                 890                 895     


Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly Asp 
            900                 905                 910         


Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu 
        915                 920                 925             


His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe Val 
    930                 935                 940                 


Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr 
945                 950                 955                 960 


Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln 
                965                 970                 975     


Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn Asp 
            980                 985                 990         


Met Arg Phe Gly Ala Gly Thr Arg  Leu Thr Val Lys Pro  Asn Ile Gln 
        995                 1000                 1005             


Asn Pro  Asp Pro Ala Val Tyr  Gln Leu Arg Asp Ser  Lys Ser Ser 
    1010                 1015                 1020             


Asp Lys  Ser Val Cys Leu Phe  Thr Asp Phe Asp Ser  Gln Thr Asn 
    1025                 1030                 1035             


Val Ser  Gln Ser Lys Asp Ser  Asp Val Tyr Ile Thr  Asp Lys Thr 
    1040                 1045                 1050             


Val Leu  Asp Met Arg Ser Met  Asp Phe Lys Ser Asn  Ser Ala Val 
    1055                 1060                 1065             


Ala Trp  Ser Asn Lys Ser Asp  Phe Ala Cys Ala Asn  Ala Phe Asn 
    1070                 1075                 1080             


Asn Ser  Ile Ile Pro Glu Asp  Thr Phe Phe Pro Ser  Pro Glu Ser 
    1085                 1090                 1095             


Ser Cys  Asp Val Lys Leu Val  Glu Lys Ser Phe Glu  Thr Asp Thr 
    1100                 1105                 1110             


Asn Leu  Asn Phe Gln Asn Leu  Ser Val Ile Gly Phe  Arg Ile Leu 
    1115                 1120                 1125             


Leu Leu  Lys Val Ala Gly Phe  Asn Leu Leu Met Thr  Leu Arg Leu 
    1130                 1135                 1140             


Trp Ser  Ser 
    1145     


<210>  273
<211>  4308
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8b1(S19).CD8a(S19).TCR.WPREmut2 construct nucleotide sequence

<400>  273
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gaattcggcc tgagctggct      420

gttcctggtg gccatcctga agggcgtgca gtgcctgcag cagacaccgg cctacatcaa      480

agtgcagacc aacaagatgg tcatgctgtc ctgcgaggcc aagatttccc tctccaacat      540

gcggatctat tggttgcggc agagacaggc gccttcctcg gactcccacc atgagttctt      600

ggccctgtgg gactccgcca agggaactat tcacggcgaa gaagtggaac aggagaagat      660

cgccgtgttt cgcgatgcct cccgctttat actgaatctg acctccgtga agcccgaaga      720

tagcgggatc tacttttgca tgattgtggg ctcacccgaa ctgaccttcg ggaagggcac      780

tcagctgagc gtggtggact tcctccccac taccgcccaa cccactaaga agtcaaccct      840

gaagaagcgg gtttgcagac tcccacggcc ggaaacgcag aagggtccgc tgtgttcccc      900

gatcaccctg gggctccttg tggctggagt gctggtcctt ctggtgtccc ttggcgtcgc      960

cattcacctc tgctgccgga gaaggagggc cagactgagg ttcatgaagc agttctacaa     1020

gcgggccaag agatctggca gcggcgccac caatttcagc ctgctgaaac aggccggcga     1080

cgtggaagag aaccctggcc ccatggagtt cggcctgagc tggctgttcc tggtggccat     1140

cctgaagggc gtgcagtgct cccaattccg ggtgtcccct ctggatcgca cctggaacct     1200

cggggaaacg gtggagctca agtgtcaagt cctcctgtcg aacccgacca gcggatgcag     1260

ctggctgttc cagccgagag gagctgccgc ctcacccacc ttcctcctgt acttgagcca     1320

gaacaagccg aaggccgctg agggtctgga cacccagcgc ttctcgggca aacggctggg     1380

agacactttt gtgctgactc tctccgactt ccggcgggag aacgagggct actacttctg     1440

ctctgcgctc tccaattcaa tcatgtactt ctcacacttc gtgccggtgt tcctgcctgc     1500

caagcccacc actactccgg cacccagacc tccaactccc gctcccacca tcgcgtccca     1560

acccctttcg ctgcgccctg aagcgtgtcg gcctgctgct ggaggagccg tgcatacccg     1620

cggtctggac ttcgcgtgcg acatctacat ttgggcccct ttggctggca cctgtggagt     1680

gctgctcctg tcccttgtga tcaccctgta ctgcaaccac cggaataggc ggagagtctg     1740

caagtgtccg cggcctgtcg tgaagtcagg agataagccg agcctgtccg cacgctacgt     1800

gcgggccaag agatctggca gcggcgaggg cagaggcagc ctgctgacct gcggcgacgt     1860

ggaggagaac cccggcccca tggactcttg gaccttctgc tgcgtgagcc tgtgcatcct     1920

ggtggccaag cacacagacg ccggcgtgat ccagtcccct aggcacgagg tgaccgagat     1980

gggccaggag gtgacactgc gctgtaagcc aatctctggc cacaacagcc tgttttggta     2040

tagggagacc atgatgcgcg gcctggagct gctgatctac ttcaataaca atgtgcccat     2100

cgacgattcc ggcatgcctg aggatcggtt ttctgccaag atgcccaatg ccagcttctc     2160

cacactgaag atccagccta gcgagccaag agactccgcc gtgtattttt gcgcctctag     2220

cccaggcagc accgatacac agtacttcgg accaggaacc aggctgacag tgctggagga     2280

cctgaagaac gtgttccccc ctgaggtggc cgtgtttgag ccctctgagg ccgagatcag     2340

ccacacccag aaggccaccc tggtgtgcct ggcaaccggc ttctatcctg atcacgtgga     2400

gctgtcctgg tgggtgaacg gcaaggaggt gcacagcggc gtgtccacag acccacagcc     2460

cctgaaggag cagccagccc tgaatgatag ccggtattgc ctgtcctctc ggctgagagt     2520

gtccgccacc ttttggcaga acccccggaa tcacttcaga tgtcaggtgc agttttacgg     2580

cctgtccgag aacgatgagt ggacccagga ccgggccaag cctgtgacac agatcgtgtc     2640

tgccgaggca tggggaagag cagactgtgg cttcacctct gagagctacc agcagggcgt     2700

gctgagcgcc accatcctgt atgagatcct gctgggcaag gccacactgt acgccgtcct     2760

ggtctccgct ctggtgctga tggcaatggt caaaagaaaa gatagtcggg gacgggccaa     2820

gagatctggc agcggccagt gcaccaacta cgccctgctg aagctggccg gcgacgtgga     2880

gagcaacccc ggccccatgg agaagaatcc cctggctgcc cccctgctga tcctgtggtt     2940

tcacctggac tgcgtgtcct ctatcctgaa tgtggaacag agcccacaga gcctgcacgt     3000

gcaggagggc gactccacca acttcacatg ctcttttcct agctccaact tctacgccct     3060

gcactggtac agaaaggaga ccgcaaagtc cccagaggcc ctgttcgtga tgacactgaa     3120

cggcgatgag aagaagaagg gccgcatcag cgccaccctg aatacaaagg agggctactc     3180

ctatctgtac atcaagggct cccagcctga ggactctgcc acctatctgt gcgccctgta     3240

caacaataac gatatgcggt ttggcgccgg caccagactg acagtgaagc caaacatcca     3300

gaatccagac cccgccgtgt atcagctgcg ggacagcaag tctagcgata agagcgtgtg     3360

cctgttcacc gactttgatt ctcagacaaa cgtgagccag tccaaggaca gcgacgtgta     3420

catcaccgac aagacagtgc tggatatgag aagcatggac ttcaagtcta acagcgccgt     3480

ggcctggtcc aataagtctg atttcgcctg cgccaatgcc tttaataact ccatcatccc     3540

cgaggatacc ttctttcctt ctccagagtc ctcttgtgac gtgaagctgg tggagaagtc     3600

tttcgagacc gatacaaacc tgaattttca gaacctgagc gtgatcggct tcaggatcct     3660

gctgctgaag gtggccggct ttaatctgct gatgaccctg aggctgtgga gctcctgaac     3720

cggtccggag catcttaccg ccatttatac ccatatttgt tctgtttttc ttgatttggg     3780

tatacattta aatgttaata aaacaaaatg gtggggcaat catttacatt ttttgggata     3840

tgtaattact agttcaggtg tattgccaca agacaaactt gttaagaaac tttcccgtta     3900

tttacgctct gttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactga     3960

tattcttaac tttgttgctc cttttacgct gtgtggattt gctgctttat tgcctctgta     4020

tcttgctatt gcttcccgta cggctttcgt tttctcctcc ttgtataaat cctggttgct     4080

gtctcttttt gaggagttgt ggcccgttgt ccgtcaacgt ggcgtggtgt gctctgtgtt     4140

tgctgacgca acccccactg gctggggcat tgccaccacc tgtcaactcc tttctgggac     4200

tttcgctttc cccctcccga tcgccacggc agaactcatc gccgcctgcc ttgcccgctg     4260

ctggacaggg gctaggttgc tgggcactga taattccgtg gtgttgtc                  4308


<210>  274
<211>  1106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8b1(S19).CD8a(S19).TCR.WPREmut2 amino acid sequence

<400>  274

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn 
            20                  25                  30          


Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met 
        35                  40                  45              


Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His 
    50                  55                  60                  


His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly 
65                  70                  75                  80  


Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg 
                85                  90                  95      


Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr 
            100                 105                 110         


Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys 
    130                 135                 140                 


Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr 
145                 150                 155                 160 


Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala 
                165                 170                 175     


Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys 
            180                 185                 190         


Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe Tyr Lys 
        195                 200                 205             


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
    210                 215                 220                 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Phe Gly Leu 
225                 230                 235                 240 


Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly Val Gln Cys Ser Gln 
                245                 250                 255     


Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu Thr Val 
            260                 265                 270         


Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly Cys Ser 
        275                 280                 285             


Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe Leu Leu 
    290                 295                 300                 


Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp Thr Gln 
305                 310                 315                 320 


Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr Leu Ser 
                325                 330                 335     


Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala Leu Ser 
            340                 345                 350         


Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala 
        355                 360                 365             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    370                 375                 380                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
385                 390                 395                 400 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
                405                 410                 415     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            420                 425                 430         


Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys 
        435                 440                 445             


Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser 
    450                 455                 460                 


Ala Arg Tyr Val Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly 
465                 470                 475                 480 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asp 
                485                 490                 495     


Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala Lys His 
            500                 505                 510         


Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met 
        515                 520                 525             


Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser 
    530                 535                 540                 


Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu Leu Ile 
545                 550                 555                 560 


Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp 
                565                 570                 575     


Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile 
            580                 585                 590         


Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser 
        595                 600                 605             


Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
    610                 615                 620                 


Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
625                 630                 635                 640 


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
                645                 650                 655     


Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
            660                 665                 670         


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
        675                 680                 685             


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
    690                 695                 700                 


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
705                 710                 715                 720 


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
                725                 730                 735     


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
            740                 745                 750         


Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val 
        755                 760                 765             


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
    770                 775                 780                 


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
785                 790                 795                 800 


Lys Asp Ser Arg Gly Arg Ala Lys Arg Ser Gly Ser Gly Gln Cys Thr 
                805                 810                 815     


Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            820                 825                 830         


Pro Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe 
        835                 840                 845             


His Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln 
    850                 855                 860                 


Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe 
865                 870                 875                 880 


Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr Ala 
                885                 890                 895     


Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys 
            900                 905                 910         


Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser 
        915                 920                 925             


Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu 
    930                 935                 940                 


Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg 
945                 950                 955                 960 


Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
                965                 970                 975     


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
            980                 985                 990         


Phe Asp Ser Gln Thr Asn Val Ser  Gln Ser Lys Asp Ser  Asp Val Tyr 
        995                 1000                 1005             


Ile Thr  Asp Lys Thr Val Leu  Asp Met Arg Ser Met  Asp Phe Lys 
    1010                 1015                 1020             


Ser Asn  Ser Ala Val Ala Trp  Ser Asn Lys Ser Asp  Phe Ala Cys 
    1025                 1030                 1035             


Ala Asn  Ala Phe Asn Asn Ser  Ile Ile Pro Glu Asp  Thr Phe Phe 
    1040                 1045                 1050             


Pro Ser  Pro Glu Ser Ser Cys  Asp Val Lys Leu Val  Glu Lys Ser 
    1055                 1060                 1065             


Phe Glu  Thr Asp Thr Asn Leu  Asn Phe Gln Asn Leu  Ser Val Ile 
    1070                 1075                 1080             


Gly Phe  Arg Ile Leu Leu Leu  Lys Val Ala Gly Phe  Asn Leu Leu 
    1085                 1090                 1095             


Met Thr  Leu Arg Leu Trp Ser  Ser 
    1100                 1105     


<210>  275
<211>  4416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8b4(S19).CD8a(S19).TCR.WPREmut2 construct nucleotide sequence

<400>  275
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gaattcggcc tgagctggct      420

gttcctggtg gccatcctga agggcgtgca gtgcctgcag cagacaccgg cctacatcaa      480

agtgcagacc aacaagatgg tcatgctgtc ctgcgaggcc aagatttccc tctccaacat      540

gcggatctat tggttgcggc agagacaggc gccttcctcg gactcccacc atgagttctt      600

ggccctgtgg gactccgcca agggaactat tcacggcgaa gaagtggaac aggagaagat      660

cgccgtgttt cgcgatgcct cccgctttat actgaatctg acctccgtga agcccgaaga      720

tagcgggatc tacttttgca tgattgtggg ctcacccgaa ctgaccttcg ggaagggcac      780

tcagctgagc gtggtggact tcctccccac taccgcccaa cccactaaga agtcaaccct      840

gaagaagcgg gtttgcagac tcccacggcc ggaaacgcag aagggtccgc tgtgttcccc      900

gatcaccctg gggctccttg tggctggagt gctggtcctt ctggtgtccc ttggcgtcgc      960

cattcacctc tgctgccgga gaaggagggc cagactgagg ttcatgaagc agaagttcaa     1020

catagtctgc ctgaagattt ccgggttcac tacttgctgc tgcttccaaa tactccagat     1080

ttcacgagaa tatgggttcg gtgtgttgct ccaaaaagac atcggtcaac gggccaagag     1140

atctggcagc ggcgccacca atttcagcct gctgaaacag gccggcgacg tggaagagaa     1200

ccctggcccc atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt     1260

gcagtgctcc caattccggg tgtcccctct ggatcgcacc tggaacctcg gggaaacggt     1320

ggagctcaag tgtcaagtcc tcctgtcgaa cccgaccagc ggatgcagct ggctgttcca     1380

gccgagagga gctgccgcct cacccacctt cctcctgtac ttgagccaga acaagccgaa     1440

ggccgctgag ggtctggaca cccagcgctt ctcgggcaaa cggctgggag acacttttgt     1500

gctgactctc tccgacttcc ggcgggagaa cgagggctac tacttctgct ctgcgctctc     1560

caattcaatc atgtacttct cacacttcgt gccggtgttc ctgcctgcca agcccaccac     1620

tactccggca cccagacctc caactcccgc tcccaccatc gcgtcccaac ccctttcgct     1680

gcgccctgaa gcgtgtcggc ctgctgctgg aggagccgtg catacccgcg gtctggactt     1740

cgcgtgcgac atctacattt gggccccttt ggctggcacc tgtggagtgc tgctcctgtc     1800

ccttgtgatc accctgtact gcaaccaccg gaataggcgg agagtctgca agtgtccgcg     1860

gcctgtcgtg aagtcaggag ataagccgag cctgtccgca cgctacgtgc gggccaagag     1920

atctggcagc ggcgagggca gaggcagcct gctgacctgc ggcgacgtgg aggagaaccc     1980

cggccccatg gactcttgga ccttctgctg cgtgagcctg tgcatcctgg tggccaagca     2040

cacagacgcc ggcgtgatcc agtcccctag gcacgaggtg accgagatgg gccaggaggt     2100

gacactgcgc tgtaagccaa tctctggcca caacagcctg ttttggtata gggagaccat     2160

gatgcgcggc ctggagctgc tgatctactt caataacaat gtgcccatcg acgattccgg     2220

catgcctgag gatcggtttt ctgccaagat gcccaatgcc agcttctcca cactgaagat     2280

ccagcctagc gagccaagag actccgccgt gtatttttgc gcctctagcc caggcagcac     2340

cgatacacag tacttcggac caggaaccag gctgacagtg ctggaggacc tgaagaacgt     2400

gttcccccct gaggtggccg tgtttgagcc ctctgaggcc gagatcagcc acacccagaa     2460

ggccaccctg gtgtgcctgg caaccggctt ctatcctgat cacgtggagc tgtcctggtg     2520

ggtgaacggc aaggaggtgc acagcggcgt gtccacagac ccacagcccc tgaaggagca     2580

gccagccctg aatgatagcc ggtattgcct gtcctctcgg ctgagagtgt ccgccacctt     2640

ttggcagaac ccccggaatc acttcagatg tcaggtgcag ttttacggcc tgtccgagaa     2700

cgatgagtgg acccaggacc gggccaagcc tgtgacacag atcgtgtctg ccgaggcatg     2760

gggaagagca gactgtggct tcacctctga gagctaccag cagggcgtgc tgagcgccac     2820

catcctgtat gagatcctgc tgggcaaggc cacactgtac gccgtcctgg tctccgctct     2880

ggtgctgatg gcaatggtca aaagaaaaga tagtcgggga cgggccaaga gatctggcag     2940

cggccagtgc accaactacg ccctgctgaa gctggccggc gacgtggaga gcaaccccgg     3000

ccccatggag aagaatcccc tggctgcccc cctgctgatc ctgtggtttc acctggactg     3060

cgtgtcctct atcctgaatg tggaacagag cccacagagc ctgcacgtgc aggagggcga     3120

ctccaccaac ttcacatgct cttttcctag ctccaacttc tacgccctgc actggtacag     3180

aaaggagacc gcaaagtccc cagaggccct gttcgtgatg acactgaacg gcgatgagaa     3240

gaagaagggc cgcatcagcg ccaccctgaa tacaaaggag ggctactcct atctgtacat     3300

caagggctcc cagcctgagg actctgccac ctatctgtgc gccctgtaca acaataacga     3360

tatgcggttt ggcgccggca ccagactgac agtgaagcca aacatccaga atccagaccc     3420

cgccgtgtat cagctgcggg acagcaagtc tagcgataag agcgtgtgcc tgttcaccga     3480

ctttgattct cagacaaacg tgagccagtc caaggacagc gacgtgtaca tcaccgacaa     3540

gacagtgctg gatatgagaa gcatggactt caagtctaac agcgccgtgg cctggtccaa     3600

taagtctgat ttcgcctgcg ccaatgcctt taataactcc atcatccccg aggatacctt     3660

ctttccttct ccagagtcct cttgtgacgt gaagctggtg gagaagtctt tcgagaccga     3720

tacaaacctg aattttcaga acctgagcgt gatcggcttc aggatcctgc tgctgaaggt     3780

ggccggcttt aatctgctga tgaccctgag gctgtggagc tcctgaaccg gtccggagca     3840

tcttaccgcc atttataccc atatttgttc tgtttttctt gatttgggta tacatttaaa     3900

tgttaataaa acaaaatggt ggggcaatca tttacatttt ttgggatatg taattactag     3960

ttcaggtgta ttgccacaag acaaacttgt taagaaactt tcccgttatt tacgctctgt     4020

tcctgttaat caacctctgg attacaaaat ttgtgaaaga ttgactgata ttcttaactt     4080

tgttgctcct tttacgctgt gtggatttgc tgctttattg cctctgtatc ttgctattgc     4140

ttcccgtacg gctttcgttt tctcctcctt gtataaatcc tggttgctgt ctctttttga     4200

ggagttgtgg cccgttgtcc gtcaacgtgg cgtggtgtgc tctgtgtttg ctgacgcaac     4260

ccccactggc tggggcattg ccaccacctg tcaactcctt tctgggactt tcgctttccc     4320

cctcccgatc gccacggcag aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     4380

taggttgctg ggcactgata attccgtggt gttgtc                               4416


<210>  276
<211>  1142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8b4(S19).CD8a(S19).TCR.WPREmut2 amino acid sequence

<400>  276

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn 
            20                  25                  30          


Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met 
        35                  40                  45              


Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His 
    50                  55                  60                  


His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly 
65                  70                  75                  80  


Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg 
                85                  90                  95      


Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr 
            100                 105                 110         


Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys 
    130                 135                 140                 


Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr 
145                 150                 155                 160 


Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala 
                165                 170                 175     


Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys 
            180                 185                 190         


Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Lys Phe Asn 
        195                 200                 205             


Ile Val Cys Leu Lys Ile Ser Gly Phe Thr Thr Cys Cys Cys Phe Gln 
    210                 215                 220                 


Ile Leu Gln Ile Ser Arg Glu Tyr Gly Phe Gly Val Leu Leu Gln Lys 
225                 230                 235                 240 


Asp Ile Gly Gln Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
                245                 250                 255     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            260                 265                 270         


Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly Val 
        275                 280                 285             


Gln Cys Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu 
    290                 295                 300                 


Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr 
305                 310                 315                 320 


Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro 
                325                 330                 335     


Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly 
            340                 345                 350         


Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val 
        355                 360                 365             


Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys 
    370                 375                 380                 


Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val 
385                 390                 395                 400 


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                405                 410                 415     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            420                 425                 430         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        435                 440                 445             


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
    450                 455                 460                 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg 
465                 470                 475                 480 


Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys 
                485                 490                 495     


Pro Ser Leu Ser Ala Arg Tyr Val Arg Ala Lys Arg Ser Gly Ser Gly 
            500                 505                 510         


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
        515                 520                 525             


Gly Pro Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu 
    530                 535                 540                 


Val Ala Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu 
545                 550                 555                 560 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
                565                 570                 575     


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu 
            580                 585                 590         


Glu Leu Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly 
        595                 600                 605             


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
    610                 615                 620                 


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
625                 630                 635                 640 


Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
                645                 650                 655     


Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
            660                 665                 670         


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
        675                 680                 685             


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
    690                 695                 700                 


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
705                 710                 715                 720 


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
                725                 730                 735     


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
            740                 745                 750         


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
        755                 760                 765             


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
    770                 775                 780                 


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
785                 790                 795                 800 


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
                805                 810                 815     


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
            820                 825                 830         


Met Val Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg Ser Gly Ser 
        835                 840                 845             


Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu 
    850                 855                 860                 


Ser Asn Pro Gly Pro Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu 
865                 870                 875                 880 


Ile Leu Trp Phe His Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu 
                885                 890                 895     


Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe 
            900                 905                 910         


Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg 
        915                 920                 925             


Lys Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn 
    930                 935                 940                 


Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys 
945                 950                 955                 960 


Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser 
                965                 970                 975     


Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly 
            980                 985                 990         


Ala Gly Thr Arg Leu Thr Val Lys  Pro Asn Ile Gln Asn  Pro Asp Pro 
        995                 1000                 1005             


Ala Val  Tyr Gln Leu Arg Asp  Ser Lys Ser Ser Asp  Lys Ser Val 
    1010                 1015                 1020             


Cys Leu  Phe Thr Asp Phe Asp  Ser Gln Thr Asn Val  Ser Gln Ser 
    1025                 1030                 1035             


Lys Asp  Ser Asp Val Tyr Ile  Thr Asp Lys Thr Val  Leu Asp Met 
    1040                 1045                 1050             


Arg Ser  Met Asp Phe Lys Ser  Asn Ser Ala Val Ala  Trp Ser Asn 
    1055                 1060                 1065             


Lys Ser  Asp Phe Ala Cys Ala  Asn Ala Phe Asn Asn  Ser Ile Ile 
    1070                 1075                 1080             


Pro Glu  Asp Thr Phe Phe Pro  Ser Pro Glu Ser Ser  Cys Asp Val 
    1085                 1090                 1095             


Lys Leu  Val Glu Lys Ser Phe  Glu Thr Asp Thr Asn  Leu Asn Phe 
    1100                 1105                 1110             


Gln Asn  Leu Ser Val Ile Gly  Phe Arg Ile Leu Leu  Leu Lys Val 
    1115                 1120                 1125             


Ala Gly  Phe Asn Leu Leu Met  Thr Leu Arg Leu Trp  Ser Ser 
    1130                 1135                 1140         


<210>  277
<211>  4407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8b5(S19).CD8a(S19).TCR.WPREmut2 construct nucleotide sequence

<400>  277
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gaattcggcc tgagctggct      420

gttcctggtg gccatcctga agggcgtgca gtgcctgcag cagacaccgg cctacatcaa      480

agtgcagacc aacaagatgg tcatgctgtc ctgcgaggcc aagatttccc tctccaacat      540

gcggatctat tggttgcggc agagacaggc gccttcctcg gactcccacc atgagttctt      600

ggccctgtgg gactccgcca agggaactat tcacggcgaa gaagtggaac aggagaagat      660

cgccgtgttt cgcgatgcct cccgctttat actgaatctg acctccgtga agcccgaaga      720

tagcgggatc tacttttgca tgattgtggg ctcacccgaa ctgaccttcg ggaagggcac      780

tcagctgagc gtggtggact tcctccccac taccgcccaa cccactaaga agtcaaccct      840

gaagaagcgg gtttgcagac tcccacggcc ggaaacgcag aagggtccgc tgtgttcccc      900

gatcaccctg gggctccttg tggctggagt gctggtcctt ctggtgtccc ttggcgtcgc      960

cattcacctc tgctgccgga gaaggagggc cagactgagg ttcatgaagc agcctcaggg     1020

agaggggatc agtggcactt tcgtgccaca atgcctccat ggctactatt ccaacaccac     1080

cacctcgcaa aagctgctga acccctggat cctgaaaacc cgggccaaga gatctggcag     1140

cggcgccacc aatttcagcc tgctgaaaca ggccggcgac gtggaagaga accctggccc     1200

catggagttc ggcctgagct ggctgttcct ggtggccatc ctgaagggcg tgcagtgctc     1260

ccaattccgg gtgtcccctc tggatcgcac ctggaacctc ggggaaacgg tggagctcaa     1320

gtgtcaagtc ctcctgtcga acccgaccag cggatgcagc tggctgttcc agccgagagg     1380

agctgccgcc tcacccacct tcctcctgta cttgagccag aacaagccga aggccgctga     1440

gggtctggac acccagcgct tctcgggcaa acggctggga gacacttttg tgctgactct     1500

ctccgacttc cggcgggaga acgagggcta ctacttctgc tctgcgctct ccaattcaat     1560

catgtacttc tcacacttcg tgccggtgtt cctgcctgcc aagcccacca ctactccggc     1620

acccagacct ccaactcccg ctcccaccat cgcgtcccaa cccctttcgc tgcgccctga     1680

agcgtgtcgg cctgctgctg gaggagccgt gcatacccgc ggtctggact tcgcgtgcga     1740

catctacatt tgggcccctt tggctggcac ctgtggagtg ctgctcctgt cccttgtgat     1800

caccctgtac tgcaaccacc ggaataggcg gagagtctgc aagtgtccgc ggcctgtcgt     1860

gaagtcagga gataagccga gcctgtccgc acgctacgtg cgggccaaga gatctggcag     1920

cggcgagggc agaggcagcc tgctgacctg cggcgacgtg gaggagaacc ccggccccat     1980

ggactcttgg accttctgct gcgtgagcct gtgcatcctg gtggccaagc acacagacgc     2040

cggcgtgatc cagtccccta ggcacgaggt gaccgagatg ggccaggagg tgacactgcg     2100

ctgtaagcca atctctggcc acaacagcct gttttggtat agggagacca tgatgcgcgg     2160

cctggagctg ctgatctact tcaataacaa tgtgcccatc gacgattccg gcatgcctga     2220

ggatcggttt tctgccaaga tgcccaatgc cagcttctcc acactgaaga tccagcctag     2280

cgagccaaga gactccgccg tgtatttttg cgcctctagc ccaggcagca ccgatacaca     2340

gtacttcgga ccaggaacca ggctgacagt gctggaggac ctgaagaacg tgttcccccc     2400

tgaggtggcc gtgtttgagc cctctgaggc cgagatcagc cacacccaga aggccaccct     2460

ggtgtgcctg gcaaccggct tctatcctga tcacgtggag ctgtcctggt gggtgaacgg     2520

caaggaggtg cacagcggcg tgtccacaga cccacagccc ctgaaggagc agccagccct     2580

gaatgatagc cggtattgcc tgtcctctcg gctgagagtg tccgccacct tttggcagaa     2640

cccccggaat cacttcagat gtcaggtgca gttttacggc ctgtccgaga acgatgagtg     2700

gacccaggac cgggccaagc ctgtgacaca gatcgtgtct gccgaggcat ggggaagagc     2760

agactgtggc ttcacctctg agagctacca gcagggcgtg ctgagcgcca ccatcctgta     2820

tgagatcctg ctgggcaagg ccacactgta cgccgtcctg gtctccgctc tggtgctgat     2880

ggcaatggtc aaaagaaaag atagtcgggg acgggccaag agatctggca gcggccagtg     2940

caccaactac gccctgctga agctggccgg cgacgtggag agcaaccccg gccccatgga     3000

gaagaatccc ctggctgccc ccctgctgat cctgtggttt cacctggact gcgtgtcctc     3060

tatcctgaat gtggaacaga gcccacagag cctgcacgtg caggagggcg actccaccaa     3120

cttcacatgc tcttttccta gctccaactt ctacgccctg cactggtaca gaaaggagac     3180

cgcaaagtcc ccagaggccc tgttcgtgat gacactgaac ggcgatgaga agaagaaggg     3240

ccgcatcagc gccaccctga atacaaagga gggctactcc tatctgtaca tcaagggctc     3300

ccagcctgag gactctgcca cctatctgtg cgccctgtac aacaataacg atatgcggtt     3360

tggcgccggc accagactga cagtgaagcc aaacatccag aatccagacc ccgccgtgta     3420

tcagctgcgg gacagcaagt ctagcgataa gagcgtgtgc ctgttcaccg actttgattc     3480

tcagacaaac gtgagccagt ccaaggacag cgacgtgtac atcaccgaca agacagtgct     3540

ggatatgaga agcatggact tcaagtctaa cagcgccgtg gcctggtcca ataagtctga     3600

tttcgcctgc gccaatgcct ttaataactc catcatcccc gaggatacct tctttccttc     3660

tccagagtcc tcttgtgacg tgaagctggt ggagaagtct ttcgagaccg atacaaacct     3720

gaattttcag aacctgagcg tgatcggctt caggatcctg ctgctgaagg tggccggctt     3780

taatctgctg atgaccctga ggctgtggag ctcctgaacc ggtccggagc atcttaccgc     3840

catttatacc catatttgtt ctgtttttct tgatttgggt atacatttaa atgttaataa     3900

aacaaaatgg tggggcaatc atttacattt tttgggatat gtaattacta gttcaggtgt     3960

attgccacaa gacaaacttg ttaagaaact ttcccgttat ttacgctctg ttcctgttaa     4020

tcaacctctg gattacaaaa tttgtgaaag attgactgat attcttaact ttgttgctcc     4080

ttttacgctg tgtggatttg ctgctttatt gcctctgtat cttgctattg cttcccgtac     4140

ggctttcgtt ttctcctcct tgtataaatc ctggttgctg tctctttttg aggagttgtg     4200

gcccgttgtc cgtcaacgtg gcgtggtgtg ctctgtgttt gctgacgcaa cccccactgg     4260

ctggggcatt gccaccacct gtcaactcct ttctgggact ttcgctttcc ccctcccgat     4320

cgccacggca gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctaggttgct     4380

gggcactgat aattccgtgg tgttgtc                                         4407


<210>  278
<211>  1139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8b5(S19).CD8a(S19).TCR.WPREmut2 amino acid sequence

<400>  278

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn 
            20                  25                  30          


Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met 
        35                  40                  45              


Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His 
    50                  55                  60                  


His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly 
65                  70                  75                  80  


Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg 
                85                  90                  95      


Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr 
            100                 105                 110         


Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys 
    130                 135                 140                 


Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr 
145                 150                 155                 160 


Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala 
                165                 170                 175     


Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys 
            180                 185                 190         


Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro Gln Gly 
        195                 200                 205             


Glu Gly Ile Ser Gly Thr Phe Val Pro Gln Cys Leu His Gly Tyr Tyr 
    210                 215                 220                 


Ser Asn Thr Thr Thr Ser Gln Lys Leu Leu Asn Pro Trp Ile Leu Lys 
225                 230                 235                 240 


Thr Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                245                 250                 255     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Phe Gly 
            260                 265                 270         


Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly Val Gln Cys Ser 
        275                 280                 285             


Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu Thr 
    290                 295                 300                 


Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly Cys 
305                 310                 315                 320 


Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe Leu 
                325                 330                 335     


Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp Thr 
            340                 345                 350         


Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr Leu 
        355                 360                 365             


Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala Leu 
    370                 375                 380                 


Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro 
385                 390                 395                 400 


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                405                 410                 415     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            420                 425                 430         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        435                 440                 445             


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    450                 455                 460                 


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
465                 470                 475                 480 


Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu 
                485                 490                 495     


Ser Ala Arg Tyr Val Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg 
            500                 505                 510         


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
        515                 520                 525             


Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala Lys 
    530                 535                 540                 


His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu 
545                 550                 555                 560 


Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn 
                565                 570                 575     


Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu Leu 
            580                 585                 590         


Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu 
        595                 600                 605             


Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys 
    610                 615                 620                 


Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser 
625                 630                 635                 640 


Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
                645                 650                 655     


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
            660                 665                 670         


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
        675                 680                 685             


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
    690                 695                 700                 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
705                 710                 715                 720 


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
                725                 730                 735     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
            740                 745                 750         


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
        755                 760                 765             


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
    770                 775                 780                 


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
785                 790                 795                 800 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                805                 810                 815     


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
            820                 825                 830         


Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg Ser Gly Ser Gly Gln Cys 
        835                 840                 845             


Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
    850                 855                 860                 


Gly Pro Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp 
865                 870                 875                 880 


Phe His Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro 
                885                 890                 895     


Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser 
            900                 905                 910         


Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr 
        915                 920                 925             


Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu 
    930                 935                 940                 


Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr 
945                 950                 955                 960 


Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr 
                965                 970                 975     


Leu Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr 
            980                 985                 990         


Arg Leu Thr Val Lys Pro Asn Ile  Gln Asn Pro Asp Pro  Ala Val Tyr 
        995                 1000                 1005             


Gln Leu  Arg Asp Ser Lys Ser  Ser Asp Lys Ser Val  Cys Leu Phe 
    1010                 1015                 1020             


Thr Asp  Phe Asp Ser Gln Thr  Asn Val Ser Gln Ser  Lys Asp Ser 
    1025                 1030                 1035             


Asp Val  Tyr Ile Thr Asp Lys  Thr Val Leu Asp Met  Arg Ser Met 
    1040                 1045                 1050             


Asp Phe  Lys Ser Asn Ser Ala  Val Ala Trp Ser Asn  Lys Ser Asp 
    1055                 1060                 1065             


Phe Ala  Cys Ala Asn Ala Phe  Asn Asn Ser Ile Ile  Pro Glu Asp 
    1070                 1075                 1080             


Thr Phe  Phe Pro Ser Pro Glu  Ser Ser Cys Asp Val  Lys Leu Val 
    1085                 1090                 1095             


Glu Lys  Ser Phe Glu Thr Asp  Thr Asn Leu Asn Phe  Gln Asn Leu 
    1100                 1105                 1110             


Ser Val  Ile Gly Phe Arg Ile  Leu Leu Leu Lys Val  Ala Gly Phe 
    1115                 1120                 1125             


Asn Leu  Leu Met Thr Leu Arg  Leu Trp Ser Ser 
    1130                 1135                 


<210>  279
<211>  3573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8a(S19).CD8bstalk.TCR.WPREmut2 construct nucleotide sequence

<400>  279
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gagttcggcc tgagctggct      420

gttcctggtg gccatcctga agggcgtgca gtgctcccaa ttccgggtgt cccctctgga      480

tcgcacctgg aacctcgggg aaacggtgga gctcaagtgt caagtcctcc tgtcgaaccc      540

gaccagcgga tgcagctggc tgttccagcc gagaggagct gccgcctcac ccaccttcct      600

cctgtacttg agccagaaca agccgaaggc cgctgagggt ctggacaccc agcgcttctc      660

gggcaaacgg ctgggagaca cttttgtgct gactctctcc gacttccggc gggagaacga      720

gggctactac ttctgctctg cgctctccaa ttcaatcatg tacttctcac acttcgtgcc      780

ggtgttcctg cctgccagcg tggtggactt cctccccact accgcccaac ccactaagaa      840

gtcaaccctg aagaagcggg tttgcagact cccacggccg gaaacgcaga agggtccgct      900

gtgttccccg atctacattt gggccccttt ggctggcacc tgtggagtgc tgctcctgtc      960

ccttgtgatc accctgtact gcaaccaccg gaataggcgg agagtctgca agtgtccgcg     1020

gcctgtcgtg aagtcaggag ataagccgag cctgtccgca cgctacgtgc gggccaagag     1080

atctggcagc ggcgccacca atttcagcct gctgaaacag gccggcgacg tggaagagaa     1140

ccctggcccc atggactctt ggaccttctg ctgcgtgagc ctgtgcatcc tggtggccaa     1200

gcacacagac gccggcgtga tccagtcccc taggcacgag gtgaccgaga tgggccagga     1260

ggtgacactg cgctgtaagc caatctctgg ccacaacagc ctgttttggt atagggagac     1320

catgatgcgc ggcctggagc tgctgatcta cttcaataac aatgtgccca tcgacgattc     1380

cggcatgcct gaggatcggt tttctgccaa gatgcccaat gccagcttct ccacactgaa     1440

gatccagcct agcgagccaa gagactccgc cgtgtatttt tgcgcctcta gcccaggcag     1500

caccgataca cagtacttcg gaccaggaac caggctgaca gtgctggagg acctgaagaa     1560

cgtgttcccc cctgaggtgg ccgtgtttga gccctctgag gccgagatca gccacaccca     1620

gaaggccacc ctggtgtgcc tggcaaccgg cttctatcct gatcacgtgg agctgtcctg     1680

gtgggtgaac ggcaaggagg tgcacagcgg cgtgtccaca gacccacagc ccctgaagga     1740

gcagccagcc ctgaatgata gccggtattg cctgtcctct cggctgagag tgtccgccac     1800

cttttggcag aacccccgga atcacttcag atgtcaggtg cagttttacg gcctgtccga     1860

gaacgatgag tggacccagg accgggccaa gcctgtgaca cagatcgtgt ctgccgaggc     1920

atggggaaga gcagactgtg gcttcacctc tgagagctac cagcagggcg tgctgagcgc     1980

caccatcctg tatgagatcc tgctgggcaa ggccacactg tacgccgtcc tggtctccgc     2040

tctggtgctg atggcaatgg tcaaaagaaa agatagtcgg ggacgggcca agagatctgg     2100

cagcggcgag ggcagaggca gcctgctgac ctgcggcgac gtggaggaga accccggccc     2160

catggagaag aatcccctgg ctgcccccct gctgatcctg tggtttcacc tggactgcgt     2220

gtcctctatc ctgaatgtgg aacagagccc acagagcctg cacgtgcagg agggcgactc     2280

caccaacttc acatgctctt ttcctagctc caacttctac gccctgcact ggtacagaaa     2340

ggagaccgca aagtccccag aggccctgtt cgtgatgaca ctgaacggcg atgagaagaa     2400

gaagggccgc atcagcgcca ccctgaatac aaaggagggc tactcctatc tgtacatcaa     2460

gggctcccag cctgaggact ctgccaccta tctgtgcgcc ctgtacaaca ataacgatat     2520

gcggtttggc gccggcacca gactgacagt gaagccaaac atccagaatc cagaccccgc     2580

cgtgtatcag ctgcgggaca gcaagtctag cgataagagc gtgtgcctgt tcaccgactt     2640

tgattctcag acaaacgtga gccagtccaa ggacagcgac gtgtacatca ccgacaagac     2700

agtgctggat atgagaagca tggacttcaa gtctaacagc gccgtggcct ggtccaataa     2760

gtctgatttc gcctgcgcca atgcctttaa taactccatc atccccgagg ataccttctt     2820

tccttctcca gagtcctctt gtgacgtgaa gctggtggag aagtctttcg agaccgatac     2880

aaacctgaat tttcagaacc tgagcgtgat cggcttcagg atcctgctgc tgaaggtggc     2940

cggctttaat ctgctgatga ccctgaggct gtggagctcc tgaaccggtc cggagcatct     3000

taccgccatt tatacccata tttgttctgt ttttcttgat ttgggtatac atttaaatgt     3060

taataaaaca aaatggtggg gcaatcattt acattttttg ggatatgtaa ttactagttc     3120

aggtgtattg ccacaagaca aacttgttaa gaaactttcc cgttatttac gctctgttcc     3180

tgttaatcaa cctctggatt acaaaatttg tgaaagattg actgatattc ttaactttgt     3240

tgctcctttt acgctgtgtg gatttgctgc tttattgcct ctgtatcttg ctattgcttc     3300

ccgtacggct ttcgttttct cctccttgta taaatcctgg ttgctgtctc tttttgagga     3360

gttgtggccc gttgtccgtc aacgtggcgt ggtgtgctct gtgtttgctg acgcaacccc     3420

cactggctgg ggcattgcca ccacctgtca actcctttct gggactttcg ctttccccct     3480

cccgatcgcc acggcagaac tcatcgccgc ctgccttgcc cgctgctgga caggggctag     3540

gttgctgggc actgataatt ccgtggtgtt gtc                                  3573


<210>  280
<211>  861
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a(S19).CD8bstalk.TCR.WPREmut2 amino acid sequence

<400>  280

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn 
            20                  25                  30          


Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro 
        35                  40                  45              


Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser 
    50                  55                  60                  


Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu 
65                  70                  75                  80  


Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe 
                85                  90                  95      


Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe 
            100                 105                 110         


Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro 
        115                 120                 125             


Val Phe Leu Pro Ala Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln 
    130                 135                 140                 


Pro Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg 
145                 150                 155                 160 


Pro Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Tyr Ile Trp Ala 
                165                 170                 175     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            180                 185                 190         


Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
        195                 200                 205             


Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
    210                 215                 220                 


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
225                 230                 235                 240 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asp Ser Trp Thr 
                245                 250                 255     


Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala Lys His Thr Asp Ala 
            260                 265                 270         


Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
        275                 280                 285             


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
    290                 295                 300                 


Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn 
305                 310                 315                 320 


Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
                325                 330                 335     


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
            340                 345                 350         


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ser 
        355                 360                 365             


Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu 
    370                 375                 380                 


Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
385                 390                 395                 400 


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
                405                 410                 415     


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
            420                 425                 430         


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
        435                 440                 445             


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
    450                 455                 460                 


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
465                 470                 475                 480 


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
                485                 490                 495     


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
            500                 505                 510         


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
        515                 520                 525             


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
    530                 535                 540                 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser 
545                 550                 555                 560 


Arg Gly Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
                565                 570                 575     


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Lys Asn 
            580                 585                 590         


Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His Leu Asp Cys Val 
        595                 600                 605             


Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln 
    610                 615                 620                 


Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe 
625                 630                 635                 640 


Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Ala 
                645                 650                 655     


Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile 
            660                 665                 670         


Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys 
        675                 680                 685             


Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn 
    690                 695                 700                 


Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro 
705                 710                 715                 720 


Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
                725                 730                 735     


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
            740                 745                 750         


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr 
        755                 760                 765             


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
    770                 775                 780                 


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
785                 790                 795                 800 


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
                805                 810                 815     


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
            820                 825                 830         


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
        835                 840                 845             


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    850                 855                 860     


<210>  281
<211>  4284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCRba.CD8a.CD8b1.2.WPREmut2 construct nucleotide sequence

<400>  281
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gactcttgga ccttctgctg      420

cgtgagcctg tgcatcctgg tggccaagca cacagacgcc ggcgtgatcc agtcccctag      480

gcacgaggtg accgagatgg gccaggaggt gacactgcgc tgtaagccaa tctctggcca      540

caacagcctg ttttggtata gggagaccat gatgcgcggc ctggagctgc tgatctactt      600

caataacaat gtgcccatcg acgattccgg catgcctgag gatcggtttt ctgccaagat      660

gcccaatgcc agcttctcca cactgaagat ccagcctagc gagccaagag actccgccgt      720

gtatttttgc gcctctagcc caggcagcac cgatacacag tacttcggac caggaaccag      780

gctgacagtg ctggaggacc tgaagaacgt gttcccccct gaggtggccg tgtttgagcc      840

ctctgaggcc gagatcagcc acacccagaa ggccaccctg gtgtgcctgg caaccggctt      900

ctatcctgat cacgtggagc tgtcctggtg ggtgaacggc aaggaggtgc acagcggcgt      960

gtccacagac ccacagcccc tgaaggagca gccagccctg aatgatagcc ggtattgcct     1020

gtcctctcgg ctgagagtgt ccgccacctt ttggcagaac ccccggaatc acttcagatg     1080

tcaggtgcag ttttacggcc tgtccgagaa cgatgagtgg acccaggacc gggccaagcc     1140

tgtgacacag atcgtgtctg ccgaggcatg gggaagagca gactgtggct tcacctctga     1200

gagctaccag cagggcgtgc tgagcgccac catcctgtat gagatcctgc tgggcaaggc     1260

cacactgtac gccgtcctgg tctccgctct ggtgctgatg gcaatggtca aaagaaaaga     1320

tagtcgggga cgggccaaga gatctggcag cggcgagggc agaggcagcc tgctgacctg     1380

cggcgacgtg gaggagaacc ccggccccat ggagaagaat cccctggctg cccccctgct     1440

gatcctgtgg tttcacctgg actgcgtgtc ctctatcctg aatgtggaac agagcccaca     1500

gagcctgcac gtgcaggagg gcgactccac caacttcaca tgctcttttc ctagctccaa     1560

cttctacgcc ctgcactggt acagaaagga gaccgcaaag tccccagagg ccctgttcgt     1620

gatgacactg aacggcgatg agaagaagaa gggccgcatc agcgccaccc tgaatacaaa     1680

ggagggctac tcctatctgt acatcaaggg ctcccagcct gaggactctg ccacctatct     1740

gtgcgccctg tacaacaata acgatatgcg gtttggcgcc ggcaccagac tgacagtgaa     1800

gccaaacatc cagaatccag accccgccgt gtatcagctg cgggacagca agtctagcga     1860

taagagcgtg tgcctgttca ccgactttga ttctcagaca aacgtgagcc agtccaagga     1920

cagcgacgtg tacatcaccg acaagacagt gctggatatg agaagcatgg acttcaagtc     1980

taacagcgcc gtggcctggt ccaataagtc tgatttcgcc tgcgccaatg cctttaataa     2040

ctccatcatc cccgaggata ccttctttcc ttctccagag tcctcttgtg acgtgaagct     2100

ggtggagaag tctttcgaga ccgatacaaa cctgaatttt cagaacctga gcgtgatcgg     2160

cttcaggatc ctgctgctga aggtggccgg ctttaatctg ctgatgaccc tgaggctgtg     2220

gagctcccgg gccaagagat ctggcagcgg ccagtgcacc aactacgccc tgctgaagct     2280

ggccggcgac gtggagagca accccggccc catggcgctt cccgtgaccg cactcctgtt     2340

gccccttgcc ctgctgttgc acgccgcacg acctagccag ttcagagtgt cccccctgga     2400

ccggacctgg aacctgggag agacagtgga actgaagtgc caggtgctgc tgagcaaccc     2460

caccagcggc tgctcttggc tgtttcagcc tagaggcgcc gctgccagcc ctacctttct     2520

gctgtacctg agccagaaca agcccaaggc cgccgagggc ctggacaccc agagattcag     2580

cggcaagaga ctgggcgaca ccttcgtgct gaccctgagc gacttcagaa gagagaacga     2640

gggctactac ttctgcagcg ccctgagcaa cagcatcatg tacttcagcc acttcgtgcc     2700

cgtgtttctg cccgccaagc ctaccacaac ccctgcccct agacctccta ccccagcccc     2760

tacaatcgcc agccagcctc tgtctctgag gcccgaggct tgtagacctg ctgctggcgg     2820

agccgtgcac accagaggac tggatttcgc ctgcgacatc tacatctggg cccctctggc     2880

cggcacatgt ggcgtgctgc tgctgtccct cgtgatcacc ctgtactgca accaccggaa     2940

ccggcggaga gtgtgcaagt gccctagacc cgtcgtgaag tccggcgaca agcctagcct     3000

gagcgccaga tacgtgcggg ccaagagatc tggcagcggc gccaccaatt tcagcctgct     3060

gaaacaggcc ggcgacgtgg aagagaaccc tggccccatg cgcccgagac tgtggcttct     3120

gctcgccgcg caactgactg tcctgcacgg aaacagcgtg ctgcagcaga caccggccta     3180

catcaaagtg cagaccaaca agatggtcat gctgtcctgc gaggccaaga tttccctctc     3240

caacatgcgg atctattggt tgcggcagag acaggcgcct tcctcggact cccaccatga     3300

gttcttggcc ctgtgggact ccgccaaggg aactattcac ggcgaagaag tggaacagga     3360

gaagatcgcc gtgtttcgcg atgcctcccg ctttatactg aatctgacct ccgtgaagcc     3420

cgaagatagc gggatctact tttgcatgat tgtgggctca cccgaactga ccttcgggaa     3480

gggcactcag ctgagcgtgg tggacttcct ccccactacc gcccaaccca ctaagaagtc     3540

aaccctgaag aagcgggttt gcagactccc acggccggaa acgcagaagg gtctgaaagg     3600

taaggtttac caagagcctt tgtcaccgaa cgcttgtatg gacacgaccg ctatcctcca     3660

accgcatagg tcttgtctca ctcacgggtc atgaaccggt ccggagcatc ttaccgccat     3720

ttatacccat atttgttctg tttttcttga tttgggtata catttaaatg ttaataaaac     3780

aaaatggtgg ggcaatcatt tacatttttt gggatatgta attactagtt caggtgtatt     3840

gccacaagac aaacttgtta agaaactttc ccgttattta cgctctgttc ctgttaatca     3900

acctctggat tacaaaattt gtgaaagatt gactgatatt cttaactttg ttgctccttt     3960

tacgctgtgt ggatttgctg ctttattgcc tctgtatctt gctattgctt cccgtacggc     4020

tttcgttttc tcctccttgt ataaatcctg gttgctgtct ctttttgagg agttgtggcc     4080

cgttgtccgt caacgtggcg tggtgtgctc tgtgtttgct gacgcaaccc ccactggctg     4140

gggcattgcc accacctgtc aactcctttc tgggactttc gctttccccc tcccgatcgc     4200

cacggcagaa ctcatcgccg cctgccttgc ccgctgctgg acaggggcta ggttgctggg     4260

cactgataat tccgtggtgt tgtc                                            4284


<210>  282
<211>  1098
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCRba.CD8a.CD8b1.2.WPREmut2 amino acid sequence

<400>  282

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg Ser Gly Ser Gly Glu 
305                 310                 315                 320 


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
                325                 330                 335     


Pro Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe 
            340                 345                 350         


His Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln 
        355                 360                 365             


Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe 
    370                 375                 380                 


Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr Ala 
385                 390                 395                 400 


Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys 
                405                 410                 415     


Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser 
            420                 425                 430         


Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu 
        435                 440                 445             


Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg 
    450                 455                 460                 


Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
465                 470                 475                 480 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
                485                 490                 495     


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
            500                 505                 510         


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
        515                 520                 525             


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
    530                 535                 540                 


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
545                 550                 555                 560 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
                565                 570                 575     


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
            580                 585                 590         


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
        595                 600                 605             


Ser Ser Arg Ala Lys Arg Ser Gly Ser Gly Gln Cys Thr Asn Tyr Ala 
    610                 615                 620                 


Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Ala 
625                 630                 635                 640 


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
                645                 650                 655     


Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn 
            660                 665                 670         


Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro 
        675                 680                 685             


Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser 
    690                 695                 700                 


Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu 
705                 710                 715                 720 


Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe 
                725                 730                 735     


Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe 
            740                 745                 750         


Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro 
        755                 760                 765             


Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    770                 775                 780                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
785                 790                 795                 800 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                805                 810                 815     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            820                 825                 830         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
        835                 840                 845             


Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp 
    850                 855                 860                 


Lys Pro Ser Leu Ser Ala Arg Tyr Val Arg Ala Lys Arg Ser Gly Ser 
865                 870                 875                 880 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                885                 890                 895     


Asn Pro Gly Pro Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln 
            900                 905                 910         


Leu Thr Val Leu His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr 
        915                 920                 925             


Ile Lys Val Gln Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys 
    930                 935                 940                 


Ile Ser Leu Ser Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala 
945                 950                 955                 960 


Pro Ser Ser Asp Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala 
                965                 970                 975     


Lys Gly Thr Ile His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val 
            980                 985                 990         


Phe Arg Asp Ala Ser Arg Phe Ile  Leu Asn Leu Thr Ser  Val Lys Pro 
        995                 1000                 1005             


Glu Asp  Ser Gly Ile Tyr Phe  Cys Met Ile Val Gly  Ser Pro Glu 
    1010                 1015                 1020             


Leu Thr  Phe Gly Lys Gly Thr  Gln Leu Ser Val Val  Asp Phe Leu 
    1025                 1030                 1035             


Pro Thr  Thr Ala Gln Pro Thr  Lys Lys Ser Thr Leu  Lys Lys Arg 
    1040                 1045                 1050             


Val Cys  Arg Leu Pro Arg Pro  Glu Thr Gln Lys Gly  Leu Lys Gly 
    1055                 1060                 1065             


Lys Val  Tyr Gln Glu Pro Leu  Ser Pro Asn Ala Cys  Met Asp Thr 
    1070                 1075                 1080             


Thr Ala  Ile Leu Gln Pro His  Arg Ser Cys Leu Thr  His Gly Ser 
    1085                 1090                 1095             


<210>  283
<211>  3606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT-SPa/CD8a-Ig like domain 1/CD8bstalk/CD4 TM+IC/TCRba/WPREmut2 
       construct nucleotide sequence

<400>  283
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gcgcttcccg tgaccgcact      420

cctgttgccc cttgccctgc tgttgcacgc cgcacgacct tcccaattcc gggtgtcccc      480

tctggatcgc acctggaacc tcggggaaac ggtggagctc aagtgtcaag tcctcctgtc      540

gaacccgacc agcggatgca gctggctgtt ccagccgaga ggagctgccg cctcacccac      600

cttcctcctg tacttgagcc agaacaagcc gaaggccgct gagggtctgg acacccagcg      660

cttctcgggc aaacggctgg gagacacttt tgtgctgact ctctccgact tccggcggga      720

gaacgagggc tactacttct gctctgcgct ctccaattca atcatgtact tctcacactt      780

cgtgccggtg ttcctgcctg ccagcgtggt ggacttcctc cccactaccg cccaacccac      840

taagaagtca accctgaaga agcgggtttg cagactccca cggccggaaa cgcagaaggg      900

tccgctgtgt tccccgatgg ccctgattgt gctggggggc gtcgccggcc tcctgctttt      960

cattgggcta ggcatcttct tctgtgtcag gtgccggcac cgaaggcgcc aagcagagcg     1020

gatgtctcag atcaagagac tcctcagtga gaagaagacc tgccagtgtc ctcaccggtt     1080

tcagaagaca tgtagcccca ttcgggccaa gagatctggc agcggcgcca ccaatttcag     1140

cctgctgaaa caggccggcg acgtggaaga gaaccctggc cccatggact cttggacctt     1200

ctgctgcgtg agcctgtgca tcctggtggc caagcacaca gacgccggcg tgatccagtc     1260

ccctaggcac gaggtgaccg agatgggcca ggaggtgaca ctgcgctgta agccaatctc     1320

tggccacaac agcctgtttt ggtataggga gaccatgatg cgcggcctgg agctgctgat     1380

ctacttcaat aacaatgtgc ccatcgacga ttccggcatg cctgaggatc ggttttctgc     1440

caagatgccc aatgccagct tctccacact gaagatccag cctagcgagc caagagactc     1500

cgccgtgtat ttttgcgcct ctagcccagg cagcaccgat acacagtact tcggaccagg     1560

aaccaggctg acagtgctgg aggacctgaa gaacgtgttc ccccctgagg tggccgtgtt     1620

tgagccctct gaggccgaga tcagccacac ccagaaggcc accctggtgt gcctggcaac     1680

cggcttctat cctgatcacg tggagctgtc ctggtgggtg aacggcaagg aggtgcacag     1740

cggcgtgtcc acagacccac agcccctgaa ggagcagcca gccctgaatg atagccggta     1800

ttgcctgtcc tctcggctga gagtgtccgc caccttttgg cagaaccccc ggaatcactt     1860

cagatgtcag gtgcagtttt acggcctgtc cgagaacgat gagtggaccc aggaccgggc     1920

caagcctgtg acacagatcg tgtctgccga ggcatgggga agagcagact gtggcttcac     1980

ctctgagagc taccagcagg gcgtgctgag cgccaccatc ctgtatgaga tcctgctggg     2040

caaggccaca ctgtacgccg tcctggtctc cgctctggtg ctgatggcaa tggtcaaaag     2100

aaaagatagt cggggacggg ccaagagatc tggcagcggc gagggcagag gcagcctgct     2160

gacctgcggc gacgtggagg agaaccccgg ccccatggag aagaatcccc tggctgcccc     2220

cctgctgatc ctgtggtttc acctggactg cgtgtcctct atcctgaatg tggaacagag     2280

cccacagagc ctgcacgtgc aggagggcga ctccaccaac ttcacatgct cttttcctag     2340

ctccaacttc tacgccctgc actggtacag aaaggagacc gcaaagtccc cagaggccct     2400

gttcgtgatg acactgaacg gcgatgagaa gaagaagggc cgcatcagcg ccaccctgaa     2460

tacaaaggag ggctactcct atctgtacat caagggctcc cagcctgagg actctgccac     2520

ctatctgtgc gccctgtaca acaataacga tatgcggttt ggcgccggca ccagactgac     2580

agtgaagcca aacatccaga atccagaccc cgccgtgtat cagctgcggg acagcaagtc     2640

tagcgataag agcgtgtgcc tgttcaccga ctttgattct cagacaaacg tgagccagtc     2700

caaggacagc gacgtgtaca tcaccgacaa gacagtgctg gatatgagaa gcatggactt     2760

caagtctaac agcgccgtgg cctggtccaa taagtctgat ttcgcctgcg ccaatgcctt     2820

taataactcc atcatccccg aggatacctt ctttccttct ccagagtcct cttgtgacgt     2880

gaagctggtg gagaagtctt tcgagaccga tacaaacctg aattttcaga acctgagcgt     2940

gatcggcttc aggatcctgc tgctgaaggt ggccggcttt aatctgctga tgaccctgag     3000

gctgtggagc tcctgaaccg gtccggagca tcttaccgcc atttataccc atatttgttc     3060

tgtttttctt gatttgggta tacatttaaa tgttaataaa acaaaatggt ggggcaatca     3120

tttacatttt ttgggatatg taattactag ttcaggtgta ttgccacaag acaaacttgt     3180

taagaaactt tcccgttatt tacgctctgt tcctgttaat caacctctgg attacaaaat     3240

ttgtgaaaga ttgactgata ttcttaactt tgttgctcct tttacgctgt gtggatttgc     3300

tgctttattg cctctgtatc ttgctattgc ttcccgtacg gctttcgttt tctcctcctt     3360

gtataaatcc tggttgctgt ctctttttga ggagttgtgg cccgttgtcc gtcaacgtgg     3420

cgtggtgtgc tctgtgtttg ctgacgcaac ccccactggc tggggcattg ccaccacctg     3480

tcaactcctt tctgggactt tcgctttccc cctcccgatc gccacggcag aactcatcgc     3540

cgcctgcctt gcccgctgct ggacaggggc taggttgctg ggcactgata attccgtggt     3600

gttgtc                                                                3606


<210>  284
<211>  872
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT-SPa/CD8a-Ig like domain 1/CD8bstalk/CD4 TM+IC/TCRba/WPREmut2 
       amino acid sequence

<400>  284

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Ser Val Val Asp Phe Leu Pro Thr Thr 
    130                 135                 140                 


Ala Gln Pro Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu 
145                 150                 155                 160 


Pro Arg Pro Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Met Ala Leu 
                165                 170                 175     


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
            180                 185                 190         


Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg 
        195                 200                 205             


Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys 
    210                 215                 220                 


Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile Arg Ala Lys Arg Ser 
225                 230                 235                 240 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                245                 250                 255     


Glu Glu Asn Pro Gly Pro Met Asp Ser Trp Thr Phe Cys Cys Val Ser 
            260                 265                 270         


Leu Cys Ile Leu Val Ala Lys His Thr Asp Ala Gly Val Ile Gln Ser 
        275                 280                 285             


Pro Arg His Glu Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys 
    290                 295                 300                 


Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met 
305                 310                 315                 320 


Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile 
                325                 330                 335     


Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn 
            340                 345                 350         


Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser 
        355                 360                 365             


Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr 
    370                 375                 380                 


Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val 
385                 390                 395                 400 


Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser 
                405                 410                 415     


His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro 
            420                 425                 430         


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
        435                 440                 445             


Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn 
    450                 455                 460                 


Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe 
465                 470                 475                 480 


Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly 
                485                 490                 495     


Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr 
            500                 505                 510         


Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr 
        515                 520                 525             


Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu 
    530                 535                 540                 


Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu 
545                 550                 555                 560 


Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
            580                 585                 590         


Val Glu Glu Asn Pro Gly Pro Met Glu Lys Asn Pro Leu Ala Ala Pro 
        595                 600                 605             


Leu Leu Ile Leu Trp Phe His Leu Asp Cys Val Ser Ser Ile Leu Asn 
    610                 615                 620                 


Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr 
625                 630                 635                 640 


Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp 
                645                 650                 655     


Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr 
            660                 665                 670         


Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn 
        675                 680                 685             


Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu 
    690                 695                 700                 


Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg 
705                 710                 715                 720 


Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn Ile Gln Asn Pro 
                725                 730                 735     


Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser 
            740                 745                 750         


Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser 
        755                 760                 765             


Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg 
    770                 775                 780                 


Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser 
785                 790                 795                 800 


Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp 
                805                 810                 815     


Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu 
            820                 825                 830         


Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val 
        835                 840                 845             


Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
    850                 855                 860                 


Met Thr Leu Arg Leu Trp Ser Ser 
865                 870         


<210>  285
<211>  3579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8a.CD8bstalk.TCR.WRPEmut2 construct nucleotide sequence

<400>  285
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gcgcttcccg tgaccgcact      420

cctgttgccc cttgccctgc tgttgcacgc cgcacgacct tcccaattcc gggtgtcccc      480

tctggatcgc acctggaacc tcggggaaac ggtggagctc aagtgtcaag tcctcctgtc      540

gaacccgacc agcggatgca gctggctgtt ccagccgaga ggagctgccg cctcacccac      600

cttcctcctg tacttgagcc agaacaagcc gaaggccgct gagggtctgg acacccagcg      660

cttctcgggc aaacggctgg gagacacttt tgtgctgact ctctccgact tccggcggga      720

gaacgagggc tactacttct gctctgcgct ctccaattca atcatgtact tctcacactt      780

cgtgccggtg ttcctgcctg ccagcgtggt ggacttcctc cccactaccg cccaacccac      840

taagaagtca accctgaaga agcgggtttg cagactccca cggccggaaa cgcagaaggg      900

tccgctgtgt tccccgatct acatttgggc ccctttggct ggcacctgtg gagtgctgct      960

cctgtccctt gtgatcaccc tgtactgcaa ccaccggaat aggcggagag tctgcaagtg     1020

tccgcggcct gtcgtgaagt caggagataa gccgagcctg tccgcacgct acgtgcgggc     1080

caagagatct ggcagcggcg ccaccaattt cagcctgctg aaacaggccg gcgacgtgga     1140

agagaaccct ggccccatgg actcttggac cttctgctgc gtgagcctgt gcatcctggt     1200

ggccaagcac acagacgccg gcgtgatcca gtcccctagg cacgaggtga ccgagatggg     1260

ccaggaggtg acactgcgct gtaagccaat ctctggccac aacagcctgt tttggtatag     1320

ggagaccatg atgcgcggcc tggagctgct gatctacttc aataacaatg tgcccatcga     1380

cgattccggc atgcctgagg atcggttttc tgccaagatg cccaatgcca gcttctccac     1440

actgaagatc cagcctagcg agccaagaga ctccgccgtg tatttttgcg cctctagccc     1500

aggcagcacc gatacacagt acttcggacc aggaaccagg ctgacagtgc tggaggacct     1560

gaagaacgtg ttcccccctg aggtggccgt gtttgagccc tctgaggccg agatcagcca     1620

cacccagaag gccaccctgg tgtgcctggc aaccggcttc tatcctgatc acgtggagct     1680

gtcctggtgg gtgaacggca aggaggtgca cagcggcgtg tccacagacc cacagcccct     1740

gaaggagcag ccagccctga atgatagccg gtattgcctg tcctctcggc tgagagtgtc     1800

cgccaccttt tggcagaacc cccggaatca cttcagatgt caggtgcagt tttacggcct     1860

gtccgagaac gatgagtgga cccaggaccg ggccaagcct gtgacacaga tcgtgtctgc     1920

cgaggcatgg ggaagagcag actgtggctt cacctctgag agctaccagc agggcgtgct     1980

gagcgccacc atcctgtatg agatcctgct gggcaaggcc acactgtacg ccgtcctggt     2040

ctccgctctg gtgctgatgg caatggtcaa aagaaaagat agtcggggac gggccaagag     2100

atctggcagc ggcgagggca gaggcagcct gctgacctgc ggcgacgtgg aggagaaccc     2160

cggccccatg gagaagaatc ccctggctgc ccccctgctg atcctgtggt ttcacctgga     2220

ctgcgtgtcc tctatcctga atgtggaaca gagcccacag agcctgcacg tgcaggaggg     2280

cgactccacc aacttcacat gctcttttcc tagctccaac ttctacgccc tgcactggta     2340

cagaaaggag accgcaaagt ccccagaggc cctgttcgtg atgacactga acggcgatga     2400

gaagaagaag ggccgcatca gcgccaccct gaatacaaag gagggctact cctatctgta     2460

catcaagggc tcccagcctg aggactctgc cacctatctg tgcgccctgt acaacaataa     2520

cgatatgcgg tttggcgccg gcaccagact gacagtgaag ccaaacatcc agaatccaga     2580

ccccgccgtg tatcagctgc gggacagcaa gtctagcgat aagagcgtgt gcctgttcac     2640

cgactttgat tctcagacaa acgtgagcca gtccaaggac agcgacgtgt acatcaccga     2700

caagacagtg ctggatatga gaagcatgga cttcaagtct aacagcgccg tggcctggtc     2760

caataagtct gatttcgcct gcgccaatgc ctttaataac tccatcatcc ccgaggatac     2820

cttctttcct tctccagagt cctcttgtga cgtgaagctg gtggagaagt ctttcgagac     2880

cgatacaaac ctgaattttc agaacctgag cgtgatcggc ttcaggatcc tgctgctgaa     2940

ggtggccggc tttaatctgc tgatgaccct gaggctgtgg agctcctgaa ccggtccgga     3000

gcatcttacc gccatttata cccatatttg ttctgttttt cttgatttgg gtatacattt     3060

aaatgttaat aaaacaaaat ggtggggcaa tcatttacat tttttgggat atgtaattac     3120

tagttcaggt gtattgccac aagacaaact tgttaagaaa ctttcccgtt atttacgctc     3180

tgttcctgtt aatcaacctc tggattacaa aatttgtgaa agattgactg atattcttaa     3240

ctttgttgct ccttttacgc tgtgtggatt tgctgcttta ttgcctctgt atcttgctat     3300

tgcttcccgt acggctttcg ttttctcctc cttgtataaa tcctggttgc tgtctctttt     3360

tgaggagttg tggcccgttg tccgtcaacg tggcgtggtg tgctctgtgt ttgctgacgc     3420

aacccccact ggctggggca ttgccaccac ctgtcaactc ctttctggga ctttcgcttt     3480

ccccctcccg atcgccacgg cagaactcat cgccgcctgc cttgcccgct gctggacagg     3540

ggctaggttg ctgggcactg ataattccgt ggtgttgtc                            3579


<210>  286
<211>  863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a.CD8bstalk.TCR.WRPEmut2 amino acid sequence

<400>  286

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Ser Val Val Asp Phe Leu Pro Thr Thr 
    130                 135                 140                 


Ala Gln Pro Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu 
145                 150                 155                 160 


Pro Arg Pro Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Tyr Ile 
                165                 170                 175     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            180                 185                 190         


Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys 
        195                 200                 205             


Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg 
    210                 215                 220                 


Tyr Val Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
225                 230                 235                 240 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asp Ser 
                245                 250                 255     


Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala Lys His Thr 
            260                 265                 270         


Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        275                 280                 285             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    290                 295                 300                 


Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr 
305                 310                 315                 320 


Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                325                 330                 335     


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
            340                 345                 350         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        355                 360                 365             


Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    370                 375                 380                 


Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu 
385                 390                 395                 400 


Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys 
                405                 410                 415     


Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val 
            420                 425                 430         


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu 
        435                 440                 445             


Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg 
    450                 455                 460                 


Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg 
465                 470                 475                 480 


Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln 
                485                 490                 495     


Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly 
            500                 505                 510         


Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu 
        515                 520                 525             


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
    530                 535                 540                 


Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys 
545                 550                 555                 560 


Asp Ser Arg Gly Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly 
                565                 570                 575     


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu 
            580                 585                 590         


Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His Leu Asp 
        595                 600                 605             


Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His 
    610                 615                 620                 


Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser 
625                 630                 635                 640 


Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro 
                645                 650                 655     


Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly 
            660                 665                 670         


Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr 
        675                 680                 685             


Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu 
    690                 695                 700                 


Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val 
705                 710                 715                 720 


Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
                725                 730                 735     


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
            740                 745                 750         


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
        755                 760                 765             


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
    770                 775                 780                 


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
785                 790                 795                 800 


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
                805                 810                 815     


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
            820                 825                 830         


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
        835                 840                 845             


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    850                 855                 860             


<210>  287
<211>  3606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8a.TCR.WPREmut2 construct nucleotide sequence

<400>  287
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gcgcttcccg tgaccgcact      420

cctgttgccc cttgccctgc tgttgcacgc cgcacgacct tcccaattcc gggtgtcccc      480

tctggatcgc acctggaacc tcggggaaac ggtggagctc aagtgtcaag tcctcctgtc      540

gaacccgacc agcggatgca gctggctgtt ccagccgaga ggagctgccg cctcacccac      600

cttcctcctg tacttgagcc agaacaagcc gaaggccgct gagggtctgg acacccagcg      660

cttctcgggc aaacggctgg gagacacttt tgtgctgact ctctccgact tccggcggga      720

gaacgagggc tactacttct gctctgcgct ctccaattca atcatgtact tctcacactt      780

cgtgccggtg ttcctgcctg ccaagcccac cactactccg gcacccagac ctccaactcc      840

cgctcccacc atcgcgtccc aacccctttc gctgcgccct gaagcgtgtc ggcctgctgc      900

tggaggagcc gtgcataccc gcggtctgga cttcgcgtgc gacatctaca tttgggcccc      960

tttggctggc acctgtggag tgctgctcct gtcccttgtg atcaccctgt actgcaacca     1020

ccggaatagg cggagagtct gcaagtgtcc gcggcctgtc gtgaagtcag gagataagcc     1080

gagcctgtcc gcacgctacg tgcgggccaa gagatctggc agcggcgcca ccaatttcag     1140

cctgctgaaa caggccggcg acgtggaaga gaaccctggc cccatggact cttggacctt     1200

ctgctgcgtg agcctgtgca tcctggtggc caagcacaca gacgccggcg tgatccagtc     1260

ccctaggcac gaggtgaccg agatgggcca ggaggtgaca ctgcgctgta agccaatctc     1320

tggccacaac agcctgtttt ggtataggga gaccatgatg cgcggcctgg agctgctgat     1380

ctacttcaat aacaatgtgc ccatcgacga ttccggcatg cctgaggatc ggttttctgc     1440

caagatgccc aatgccagct tctccacact gaagatccag cctagcgagc caagagactc     1500

cgccgtgtat ttttgcgcct ctagcccagg cagcaccgat acacagtact tcggaccagg     1560

aaccaggctg acagtgctgg aggacctgaa gaacgtgttc ccccctgagg tggccgtgtt     1620

tgagccctct gaggccgaga tcagccacac ccagaaggcc accctggtgt gcctggcaac     1680

cggcttctat cctgatcacg tggagctgtc ctggtgggtg aacggcaagg aggtgcacag     1740

cggcgtgtcc acagacccac agcccctgaa ggagcagcca gccctgaatg atagccggta     1800

ttgcctgtcc tctcggctga gagtgtccgc caccttttgg cagaaccccc ggaatcactt     1860

cagatgtcag gtgcagtttt acggcctgtc cgagaacgat gagtggaccc aggaccgggc     1920

caagcctgtg acacagatcg tgtctgccga ggcatgggga agagcagact gtggcttcac     1980

ctctgagagc taccagcagg gcgtgctgag cgccaccatc ctgtatgaga tcctgctggg     2040

caaggccaca ctgtacgccg tcctggtctc cgctctggtg ctgatggcaa tggtcaaaag     2100

aaaagatagt cggggacggg ccaagagatc tggcagcggc gagggcagag gcagcctgct     2160

gacctgcggc gacgtggagg agaaccccgg ccccatggag aagaatcccc tggctgcccc     2220

cctgctgatc ctgtggtttc acctggactg cgtgtcctct atcctgaatg tggaacagag     2280

cccacagagc ctgcacgtgc aggagggcga ctccaccaac ttcacatgct cttttcctag     2340

ctccaacttc tacgccctgc actggtacag aaaggagacc gcaaagtccc cagaggccct     2400

gttcgtgatg acactgaacg gcgatgagaa gaagaagggc cgcatcagcg ccaccctgaa     2460

tacaaaggag ggctactcct atctgtacat caagggctcc cagcctgagg actctgccac     2520

ctatctgtgc gccctgtaca acaataacga tatgcggttt ggcgccggca ccagactgac     2580

agtgaagcca aacatccaga atccagaccc cgccgtgtat cagctgcggg acagcaagtc     2640

tagcgataag agcgtgtgcc tgttcaccga ctttgattct cagacaaacg tgagccagtc     2700

caaggacagc gacgtgtaca tcaccgacaa gacagtgctg gatatgagaa gcatggactt     2760

caagtctaac agcgccgtgg cctggtccaa taagtctgat ttcgcctgcg ccaatgcctt     2820

taataactcc atcatccccg aggatacctt ctttccttct ccagagtcct cttgtgacgt     2880

gaagctggtg gagaagtctt tcgagaccga tacaaacctg aattttcaga acctgagcgt     2940

gatcggcttc aggatcctgc tgctgaaggt ggccggcttt aatctgctga tgaccctgag     3000

gctgtggagc tcctgaaccg gtccggagca tcttaccgcc atttataccc atatttgttc     3060

tgtttttctt gatttgggta tacatttaaa tgttaataaa acaaaatggt ggggcaatca     3120

tttacatttt ttgggatatg taattactag ttcaggtgta ttgccacaag acaaacttgt     3180

taagaaactt tcccgttatt tacgctctgt tcctgttaat caacctctgg attacaaaat     3240

ttgtgaaaga ttgactgata ttcttaactt tgttgctcct tttacgctgt gtggatttgc     3300

tgctttattg cctctgtatc ttgctattgc ttcccgtacg gctttcgttt tctcctcctt     3360

gtataaatcc tggttgctgt ctctttttga ggagttgtgg cccgttgtcc gtcaacgtgg     3420

cgtggtgtgc tctgtgtttg ctgacgcaac ccccactggc tggggcattg ccaccacctg     3480

tcaactcctt tctgggactt tcgctttccc cctcccgatc gccacggcag aactcatcgc     3540

cgcctgcctt gcccgctgct ggacaggggc taggttgctg ggcactgata attccgtggt     3600

gttgtc                                                                3606


<210>  288
<211>  872
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a.TCR.WPREmut2 amino acid sequence

<400>  288

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val Arg Ala Lys Arg Ser 
225                 230                 235                 240 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                245                 250                 255     


Glu Glu Asn Pro Gly Pro Met Asp Ser Trp Thr Phe Cys Cys Val Ser 
            260                 265                 270         


Leu Cys Ile Leu Val Ala Lys His Thr Asp Ala Gly Val Ile Gln Ser 
        275                 280                 285             


Pro Arg His Glu Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys 
    290                 295                 300                 


Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met 
305                 310                 315                 320 


Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile 
                325                 330                 335     


Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn 
            340                 345                 350         


Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser 
        355                 360                 365             


Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr 
    370                 375                 380                 


Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val 
385                 390                 395                 400 


Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser 
                405                 410                 415     


His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro 
            420                 425                 430         


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
        435                 440                 445             


Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn 
    450                 455                 460                 


Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe 
465                 470                 475                 480 


Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly 
                485                 490                 495     


Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr 
            500                 505                 510         


Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr 
        515                 520                 525             


Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu 
    530                 535                 540                 


Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu 
545                 550                 555                 560 


Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
            580                 585                 590         


Val Glu Glu Asn Pro Gly Pro Met Glu Lys Asn Pro Leu Ala Ala Pro 
        595                 600                 605             


Leu Leu Ile Leu Trp Phe His Leu Asp Cys Val Ser Ser Ile Leu Asn 
    610                 615                 620                 


Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr 
625                 630                 635                 640 


Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp 
                645                 650                 655     


Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr 
            660                 665                 670         


Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn 
        675                 680                 685             


Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu 
    690                 695                 700                 


Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg 
705                 710                 715                 720 


Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn Ile Gln Asn Pro 
                725                 730                 735     


Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser 
            740                 745                 750         


Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser 
        755                 760                 765             


Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg 
    770                 775                 780                 


Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser 
785                 790                 795                 800 


Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp 
                805                 810                 815     


Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu 
            820                 825                 830         


Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val 
        835                 840                 845             


Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
    850                 855                 860                 


Met Thr Leu Arg Leu Trp Ser Ser 
865                 870         


<210>  289
<211>  3633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT-SPa/CD8a-Ig like domain 1(co)/CD8astalk(co)/CD4 
       TM+IC/TCRba/WPREmut2 construct nucleotide sequence

<400>  289
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gcgcttcccg tgaccgcact      420

cctgttgccc cttgccctgc tgttgcacgc cgcacgacct tcccaattcc gggtgtcccc      480

tctggatcgc acctggaacc tcggggaaac ggtggagctc aagtgtcaag tcctcctgtc      540

gaacccgacc agcggatgca gctggctgtt ccagccgaga ggagctgccg cctcacccac      600

cttcctcctg tacttgagcc agaacaagcc gaaggccgct gagggtctgg acacccagcg      660

cttctcgggc aaacggctgg gagacacttt tgtgctgact ctctccgact tccggcggga      720

gaacgagggc tactacttct gctctgcgct ctccaattca atcatgtact tctcacactt      780

cgtgccggtg ttcctgcctg ccaagcccac cactactccg gcacccagac ctccaactcc      840

cgctcccacc atcgcgtccc aacccctttc gctgcgccct gaagcgtgtc ggcctgctgc      900

tggaggagcc gtgcataccc gcggtctgga cttcgcgtgc gacatggccc tgattgtgct      960

ggggggcgtc gccggcctcc tgcttttcat tgggctaggc atcttcttct gtgtcaggtg     1020

ccggcaccga aggcgccaag cagagcggat gtctcagatc aagagactcc tcagtgagaa     1080

gaagacctgc cagtgtcctc accggtttca gaagacatgt agccccattc gggccaagag     1140

atctggcagc ggcgccacca atttcagcct gctgaaacag gccggcgacg tggaagagaa     1200

ccctggcccc atggactctt ggaccttctg ctgcgtgagc ctgtgcatcc tggtggccaa     1260

gcacacagac gccggcgtga tccagtcccc taggcacgag gtgaccgaga tgggccagga     1320

ggtgacactg cgctgtaagc caatctctgg ccacaacagc ctgttttggt atagggagac     1380

catgatgcgc ggcctggagc tgctgatcta cttcaataac aatgtgccca tcgacgattc     1440

cggcatgcct gaggatcggt tttctgccaa gatgcccaat gccagcttct ccacactgaa     1500

gatccagcct agcgagccaa gagactccgc cgtgtatttt tgcgcctcta gcccaggcag     1560

caccgataca cagtacttcg gaccaggaac caggctgaca gtgctggagg acctgaagaa     1620

cgtgttcccc cctgaggtgg ccgtgtttga gccctctgag gccgagatca gccacaccca     1680

gaaggccacc ctggtgtgcc tggcaaccgg cttctatcct gatcacgtgg agctgtcctg     1740

gtgggtgaac ggcaaggagg tgcacagcgg cgtgtccaca gacccacagc ccctgaagga     1800

gcagccagcc ctgaatgata gccggtattg cctgtcctct cggctgagag tgtccgccac     1860

cttttggcag aacccccgga atcacttcag atgtcaggtg cagttttacg gcctgtccga     1920

gaacgatgag tggacccagg accgggccaa gcctgtgaca cagatcgtgt ctgccgaggc     1980

atggggaaga gcagactgtg gcttcacctc tgagagctac cagcagggcg tgctgagcgc     2040

caccatcctg tatgagatcc tgctgggcaa ggccacactg tacgccgtcc tggtctccgc     2100

tctggtgctg atggcaatgg tcaaaagaaa agatagtcgg ggacgggcca agagatctgg     2160

cagcggcgag ggcagaggca gcctgctgac ctgcggcgac gtggaggaga accccggccc     2220

catggagaag aatcccctgg ctgcccccct gctgatcctg tggtttcacc tggactgcgt     2280

gtcctctatc ctgaatgtgg aacagagccc acagagcctg cacgtgcagg agggcgactc     2340

caccaacttc acatgctctt ttcctagctc caacttctac gccctgcact ggtacagaaa     2400

ggagaccgca aagtccccag aggccctgtt cgtgatgaca ctgaacggcg atgagaagaa     2460

gaagggccgc atcagcgcca ccctgaatac aaaggagggc tactcctatc tgtacatcaa     2520

gggctcccag cctgaggact ctgccaccta tctgtgcgcc ctgtacaaca ataacgatat     2580

gcggtttggc gccggcacca gactgacagt gaagccaaac atccagaatc cagaccccgc     2640

cgtgtatcag ctgcgggaca gcaagtctag cgataagagc gtgtgcctgt tcaccgactt     2700

tgattctcag acaaacgtga gccagtccaa ggacagcgac gtgtacatca ccgacaagac     2760

agtgctggat atgagaagca tggacttcaa gtctaacagc gccgtggcct ggtccaataa     2820

gtctgatttc gcctgcgcca atgcctttaa taactccatc atccccgagg ataccttctt     2880

tccttctcca gagtcctctt gtgacgtgaa gctggtggag aagtctttcg agaccgatac     2940

aaacctgaat tttcagaacc tgagcgtgat cggcttcagg atcctgctgc tgaaggtggc     3000

cggctttaat ctgctgatga ccctgaggct gtggagctcc tgaaccggtc cggagcatct     3060

taccgccatt tatacccata tttgttctgt ttttcttgat ttgggtatac atttaaatgt     3120

taataaaaca aaatggtggg gcaatcattt acattttttg ggatatgtaa ttactagttc     3180

aggtgtattg ccacaagaca aacttgttaa gaaactttcc cgttatttac gctctgttcc     3240

tgttaatcaa cctctggatt acaaaatttg tgaaagattg actgatattc ttaactttgt     3300

tgctcctttt acgctgtgtg gatttgctgc tttattgcct ctgtatcttg ctattgcttc     3360

ccgtacggct ttcgttttct cctccttgta taaatcctgg ttgctgtctc tttttgagga     3420

gttgtggccc gttgtccgtc aacgtggcgt ggtgtgctct gtgtttgctg acgcaacccc     3480

cactggctgg ggcattgcca ccacctgtca actcctttct gggactttcg ctttccccct     3540

cccgatcgcc acggcagaac tcatcgccgc ctgccttgcc cgctgctgga caggggctag     3600

gttgctgggc actgataatt ccgtggtgtt gtc                                  3633


<210>  290
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT-SPa/CD8a-Ig like domain 1(co)/CD8astalk(co)/CD4 
       TM+IC/TCRba/WPREmut2 amino acid sequence

<400>  290

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Met Ala Leu Ile Val Leu Gly Gly Val Ala 
            180                 185                 190         


Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys 
        195                 200                 205             


Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu 
    210                 215                 220                 


Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr 
225                 230                 235                 240 


Cys Ser Pro Ile Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
                245                 250                 255     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            260                 265                 270         


Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala Lys 
        275                 280                 285             


His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu 
    290                 295                 300                 


Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn 
305                 310                 315                 320 


Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu Leu 
                325                 330                 335     


Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu 
            340                 345                 350         


Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys 
        355                 360                 365             


Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser 
    370                 375                 380                 


Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
385                 390                 395                 400 


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
                405                 410                 415     


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
            420                 425                 430         


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
        435                 440                 445             


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
    450                 455                 460                 


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
465                 470                 475                 480 


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
                485                 490                 495     


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
            500                 505                 510         


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
        515                 520                 525             


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
    530                 535                 540                 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
545                 550                 555                 560 


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
                565                 570                 575     


Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly 
            580                 585                 590         


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
        595                 600                 605             


Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
    610                 615                 620                 


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
625                 630                 635                 640 


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
                645                 650                 655     


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr Ala Lys 
            660                 665                 670         


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
        675                 680                 685             


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
    690                 695                 700                 


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
705                 710                 715                 720 


Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu 
                725                 730                 735     


Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
            740                 745                 750         


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
        755                 760                 765             


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
    770                 775                 780                 


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
785                 790                 795                 800 


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
                805                 810                 815     


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
            820                 825                 830         


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
        835                 840                 845             


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
    850                 855                 860                 


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
865                 870                 875                 880 


Ser 
    


<210>  291
<211>  4419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTE.CD8ab.TCR.WPREmut2 construct nucleotide sequence

<400>  291
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg cgcccgagac tgtggcttct      420

gctcgccgcg caactgactg tcctgcacgg aaacagcgtg ctgcagcaga caccggccta      480

catcaaagtg cagaccaaca agatggtcat gctgtcctgc gaggccaaga tttccctctc      540

caacatgcgg atctattggt tgcggcagag acaggcgcct tcctcggact cccaccatga      600

gttcttggcc ctgtgggact ccgccaaggg aactattcac ggcgaagaag tggaacagga      660

gaagatcgcc gtgtttcgcg atgcctcccg ctttatactg aatctgacct ccgtgaagcc      720

cgaagatagc gggatctact tttgcatgat tgtgggctca cccgaactga ccttcgggaa      780

gggcactcag ctgagcgtgg tggacttcct ccccactacc gcccaaccca ctaagaagtc      840

aaccctgaag aagcgggttt gcagactccc acggccggaa acgcagaagg gtccgctgtg      900

ttccccgatc accctggggc tccttgtggc tggagtgctg gtccttctgg tgtcccttgg      960

cgtcgccatt cacctctgct gccggagaag gagggccaga ctgaggttca tgaagcagcc     1020

tcagggagag gggatcagtg gcactttcgt gccacaatgc ctccatggct actattccaa     1080

caccaccacc tcgcaaaagc tgctgaaccc ctggatcctg aaaacccggg ccaagagatc     1140

tggcagcggc gccaccaatt tcagcctgct gaaacaggcc ggcgacgtgg aagagaaccc     1200

tggccccatg gcgcttcccg tgaccgcact cctgttgccc cttgccctgc tgttgcacgc     1260

cgcacgacct tcccaattcc gggtgtcccc tctggatcgc acctggaacc tcggggaaac     1320

ggtggagctc aagtgtcaag tcctcctgtc gaacccgacc agcggatgca gctggctgtt     1380

ccagccgaga ggagctgccg cctcacccac cttcctcctg tacttgagcc agaacaagcc     1440

gaaggccgct gagggtctgg acacccagcg cttctcgggc aaacggctgg gagacacttt     1500

tgtgctgact ctctccgact tccggcggga gaacgagggc tactacttct gctctgcgct     1560

ctccaattca atcatgtact tctcacactt cgtgccggtg ttcctgcctg ccaagcccac     1620

cactactccg gcacccagac ctccaactcc cgctcccacc atcgcgtccc aacccctttc     1680

gctgcgccct gaagcgtgtc ggcctgctgc tggaggagcc gtgcataccc gcggtctgga     1740

cttcgcgtgc gacatctaca tttgggcccc tttggctggc acctgtggag tgctgctcct     1800

gtcccttgtg atcaccctgt actgcaacca ccggaatagg cggagagtct gcaagtgtcc     1860

gcggcctgtc gtgaagtcag gagataagcc gagcctgtcc gcacgctacg tgcgggccaa     1920

gagatctggc agcggcgagg gcagaggcag cctgctgacc tgcggcgacg tggaggagaa     1980

ccccggcccc atggactctt ggaccttctg ctgcgtgagc ctgtgcatcc tggtggccaa     2040

gcacacagac gccggcgtga tccagtcccc taggcacgag gtgaccgaga tgggccagga     2100

ggtgacactg cgctgtaagc caatctctgg ccacaacagc ctgttttggt atagggagac     2160

catgatgcgc ggcctggagc tgctgatcta cttcaataac aatgtgccca tcgacgattc     2220

cggcatgcct gaggatcggt tttctgccaa gatgcccaat gccagcttct ccacactgaa     2280

gatccagcct agcgagccaa gagactccgc cgtgtatttt tgcgcctcta gcccaggcag     2340

caccgataca cagtacttcg gaccaggaac caggctgaca gtgctggagg acctgaagaa     2400

cgtgttcccc cctgaggtgg ccgtgtttga gccctctgag gccgagatca gccacaccca     2460

gaaggccacc ctggtgtgcc tggcaaccgg cttctatcct gatcacgtgg agctgtcctg     2520

gtgggtgaac ggcaaggagg tgcacagcgg cgtgtccaca gacccacagc ccctgaagga     2580

gcagccagcc ctgaatgata gccggtattg cctgtcctct cggctgagag tgtccgccac     2640

cttttggcag aacccccgga atcacttcag atgtcaggtg cagttttacg gcctgtccga     2700

gaacgatgag tggacccagg accgggccaa gcctgtgaca cagatcgtgt ctgccgaggc     2760

atggggaaga gcagactgtg gcttcacctc tgagagctac cagcagggcg tgctgagcgc     2820

caccatcctg tatgagatcc tgctgggcaa ggccacactg tacgccgtcc tggtctccgc     2880

tctggtgctg atggcaatgg tcaaaagaaa agatagtcgg ggacgggcca agagatctgg     2940

cagcggccag tgcaccaact acgccctgct gaagctggcc ggcgacgtgg agagcaaccc     3000

cggccccatg gagaagaatc ccctggctgc ccccctgctg atcctgtggt ttcacctgga     3060

ctgcgtgtcc tctatcctga atgtggaaca gagcccacag agcctgcacg tgcaggaggg     3120

cgactccacc aacttcacat gctcttttcc tagctccaac ttctacgccc tgcactggta     3180

cagaaaggag accgcaaagt ccccagaggc cctgttcgtg atgacactga acggcgatga     3240

gaagaagaag ggccgcatca gcgccaccct gaatacaaag gagggctact cctatctgta     3300

catcaagggc tcccagcctg aggactctgc cacctatctg tgcgccctgt acaacaataa     3360

cgatatgcgg tttggcgccg gcaccagact gacagtgaag ccaaacatcc agaatccaga     3420

ccccgccgtg tatcagctgc gggacagcaa gtctagcgat aagagcgtgt gcctgttcac     3480

cgactttgat tctcagacaa acgtgagcca gtccaaggac agcgacgtgt acatcaccga     3540

caagacagtg ctggatatga gaagcatgga cttcaagtct aacagcgccg tggcctggtc     3600

caataagtct gatttcgcct gcgccaatgc ctttaataac tccatcatcc ccgaggatac     3660

cttctttcct tctccagagt cctcttgtga cgtgaagctg gtggagaagt ctttcgagac     3720

cgatacaaac ctgaattttc agaacctgag cgtgatcggc ttcaggatcc tgctgctgaa     3780

ggtggccggc tttaatctgc tgatgaccct gaggctgtgg agctcctgaa ccggtccgga     3840

gcatcttacc gccatttata cccatatttg ttctgttttt cttgatttgg gtatacattt     3900

aaatgttaat aaaacaaaat ggtggggcaa tcatttacat tttttgggat atgtaattac     3960

tagttcaggt gtattgccac aagacaaact tgttaagaaa ctttcccgtt atttacgctc     4020

tgttcctgtt aatcaacctc tggattacaa aatttgtgaa agattgactg atattcttaa     4080

ctttgttgct ccttttacgc tgtgtggatt tgctgcttta ttgcctctgt atcttgctat     4140

tgcttcccgt acggctttcg ttttctcctc cttgtataaa tcctggttgc tgtctctttt     4200

tgaggagttg tggcccgttg tccgtcaacg tggcgtggtg tgctctgtgt ttgctgacgc     4260

aacccccact ggctggggca ttgccaccac ctgtcaactc ctttctggga ctttcgcttt     4320

ccccctcccg atcgccacgg cagaactcat cgccgcctgc cttgcccgct gctggacagg     4380

ggctaggttg ctgggcactg ataattccgt ggtgttgtc                            4419


<210>  292
<211>  1143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTE.CD8ab.TCR.WPREmut2 amino acid sequence

<400>  292

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro 
        195                 200                 205             


Gln Gly Glu Gly Ile Ser Gly Thr Phe Val Pro Gln Cys Leu His Gly 
    210                 215                 220                 


Tyr Tyr Ser Asn Thr Thr Thr Ser Gln Lys Leu Leu Asn Pro Trp Ile 
225                 230                 235                 240 


Leu Lys Thr Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
                245                 250                 255     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
            260                 265                 270         


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
        275                 280                 285             


Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn 
    290                 295                 300                 


Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro 
305                 310                 315                 320 


Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser 
                325                 330                 335     


Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu 
            340                 345                 350         


Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe 
        355                 360                 365             


Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe 
    370                 375                 380                 


Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro 
385                 390                 395                 400 


Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                405                 410                 415     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            420                 425                 430         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        435                 440                 445             


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
    450                 455                 460                 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
465                 470                 475                 480 


Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp 
                485                 490                 495     


Lys Pro Ser Leu Ser Ala Arg Tyr Val Arg Ala Lys Arg Ser Gly Ser 
            500                 505                 510         


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
        515                 520                 525             


Pro Gly Pro Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile 
    530                 535                 540                 


Leu Val Ala Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His 
545                 550                 555                 560 


Glu Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile 
                565                 570                 575     


Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly 
            580                 585                 590         


Leu Glu Leu Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser 
        595                 600                 605             


Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe 
    610                 615                 620                 


Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr 
625                 630                 635                 640 


Phe Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro 
                645                 650                 655     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
            660                 665                 670         


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
        675                 680                 685             


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
    690                 695                 700                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
705                 710                 715                 720 


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
                725                 730                 735     


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
            740                 745                 750         


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
        755                 760                 765             


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
    770                 775                 780                 


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
785                 790                 795                 800 


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
                805                 810                 815     


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
            820                 825                 830         


Ala Met Val Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg Ser Gly 
        835                 840                 845             


Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val 
    850                 855                 860                 


Glu Ser Asn Pro Gly Pro Met Glu Lys Asn Pro Leu Ala Ala Pro Leu 
865                 870                 875                 880 


Leu Ile Leu Trp Phe His Leu Asp Cys Val Ser Ser Ile Leu Asn Val 
                885                 890                 895     


Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn 
            900                 905                 910         


Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr 
        915                 920                 925             


Arg Lys Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu 
    930                 935                 940                 


Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr 
945                 950                 955                 960 


Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp 
                965                 970                 975     


Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe 
            980                 985                 990         


Gly Ala Gly Thr Arg Leu Thr Val  Lys Pro Asn Ile Gln  Asn Pro Asp 
        995                 1000                 1005             


Pro Ala  Val Tyr Gln Leu Arg  Asp Ser Lys Ser Ser  Asp Lys Ser 
    1010                 1015                 1020             


Val Cys  Leu Phe Thr Asp Phe  Asp Ser Gln Thr Asn  Val Ser Gln 
    1025                 1030                 1035             


Ser Lys  Asp Ser Asp Val Tyr  Ile Thr Asp Lys Thr  Val Leu Asp 
    1040                 1045                 1050             


Met Arg  Ser Met Asp Phe Lys  Ser Asn Ser Ala Val  Ala Trp Ser 
    1055                 1060                 1065             


Asn Lys  Ser Asp Phe Ala Cys  Ala Asn Ala Phe Asn  Asn Ser Ile 
    1070                 1075                 1080             


Ile Pro  Glu Asp Thr Phe Phe  Pro Ser Pro Glu Ser  Ser Cys Asp 
    1085                 1090                 1095             


Val Lys  Leu Val Glu Lys Ser  Phe Glu Thr Asp Thr  Asn Leu Asn 
    1100                 1105                 1110             


Phe Gln  Asn Leu Ser Val Ile  Gly Phe Arg Ile Leu  Leu Leu Lys 
    1115                 1120                 1125             


Val Ala  Gly Phe Asn Leu Leu  Met Thr Leu Arg Leu  Trp Ser Ser 
    1130                 1135                 1140             


<210>  293
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  293

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val 
            20      


<210>  294
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  294

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  295
<211>  3631
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8a.TCR.WPRE construct nucleotide sequence

<400>  295
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactagc ggccgccccg ggtcgacgct accaccatgg cgcttcccgt gaccgcactc      420

ctgttgcccc ttgccctgct gttgcacgcc gcacgacctt cccaattccg ggtgtcccct      480

ctggatcgca cctggaacct cggggaaacg gtggagctca agtgtcaagt cctcctgtcg      540

aacccgacca gcggatgcag ctggctgttc cagccgagag gagctgccgc ctcacccacc      600

ttcctcctgt acttgagcca gaacaagccg aaggccgctg agggtctgga cacccagcgc      660

ttctcgggca aacggctggg agacactttt gtgctgactc tctccgactt ccggcgggag      720

aacgagggct actacttctg ctctgcgctc tccaattcaa tcatgtactt ctcacacttc      780

gtgccggtgt tcctgcctgc caagcccacc actactccgg cacccagacc tccaactccc      840

gctcccacca tcgcgtccca acccctttcg ctgcgccctg aagcgtgtcg gcctgctgct      900

ggaggagccg tgcatacccg cggtctggac ttcgcgtgcg acatctacat ttgggcccct      960

ttggctggca cctgtggagt gctgctcctg tcccttgtga tcaccctgta ctgcaaccac     1020

cggaataggc ggagagtctg caagtgtccg cggcctgtcg tgaagtcagg agataagccg     1080

agcctgtccg cacgctacgt gcgggccaag agatctggca gcggcgccac caatttcagc     1140

ctgctgaaac aggccggcga cgtggaagag aaccctggcc ccatggactc ttggaccttc     1200

tgctgcgtga gcctgtgcat cctggtggcc aagcacacag acgccggcgt gatccagtcc     1260

cctaggcacg aggtgaccga gatgggccag gaggtgacac tgcgctgtaa gccaatctct     1320

ggccacaaca gcctgttttg gtatagggag accatgatgc gcggcctgga gctgctgatc     1380

tacttcaata acaatgtgcc catcgacgat tccggcatgc ctgaggatcg gttttctgcc     1440

aagatgccca atgccagctt ctccacactg aagatccagc ctagcgagcc aagagactcc     1500

gccgtgtatt tttgcgcctc tagcccaggc agcaccgata cacagtactt cggaccagga     1560

accaggctga cagtgctgga ggacctgaag aacgtgttcc cccctgaggt ggccgtgttt     1620

gagccctctg aggccgagat cagccacacc cagaaggcca ccctggtgtg cctggcaacc     1680

ggcttctatc ctgatcacgt ggagctgtcc tggtgggtga acggcaagga ggtgcacagc     1740

ggcgtgtcca cagacccaca gcccctgaag gagcagccag ccctgaatga tagccggtat     1800

tgcctgtcct ctcggctgag agtgtccgcc accttttggc agaacccccg gaatcacttc     1860

agatgtcagg tgcagtttta cggcctgtcc gagaacgatg agtggaccca ggaccgggcc     1920

aagcctgtga cacagatcgt gtctgccgag gcatggggaa gagcagactg tggcttcacc     1980

tctgagagct accagcaggg cgtgctgagc gccaccatcc tgtatgagat cctgctgggc     2040

aaggccacac tgtacgccgt cctggtctcc gctctggtgc tgatggcaat ggtcaaaaga     2100

aaagatagtc ggggacgggc caagagatct ggcagcggcg agggcagagg cagcctgctg     2160

acctgcggcg acgtggagga gaaccccggc cccatggaga agaatcccct ggctgccccc     2220

ctgctgatcc tgtggtttca cctggactgc gtgtcctcta tcctgaatgt ggaacagagc     2280

ccacagagcc tgcacgtgca ggagggcgac tccaccaact tcacatgctc ttttcctagc     2340

tccaacttct acgccctgca ctggtacaga aaggagaccg caaagtcccc agaggccctg     2400

ttcgtgatga cactgaacgg cgatgagaag aagaagggcc gcatcagcgc caccctgaat     2460

acaaaggagg gctactccta tctgtacatc aagggctccc agcctgagga ctctgccacc     2520

tatctgtgcg ccctgtacaa caataacgat atgcggtttg gcgccggcac cagactgaca     2580

gtgaagccaa acatccagaa tccagacccc gccgtgtatc agctgcggga cagcaagtct     2640

agcgataaga gcgtgtgcct gttcaccgac tttgattctc agacaaacgt gagccagtcc     2700

aaggacagcg acgtgtacat caccgacaag acagtgctgg atatgagaag catggacttc     2760

aagtctaaca gcgccgtggc ctggtccaat aagtctgatt tcgcctgcgc caatgccttt     2820

aataactcca tcatccccga ggataccttc tttccttctc cagagtcctc ttgtgacgtg     2880

aagctggtgg agaagtcttt cgagaccgat acaaacctga attttcagaa cctgagcgtg     2940

atcggcttca ggatcctgct gctgaaggtg gccggcttta atctgctgat gaccctgagg     3000

ctgtggagct cctgaaccgg tccgcagtct gacgtacgcg taatcaacct ctggattaca     3060

aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat     3120

acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct     3180

ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac     3240

gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca     3300

cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca     3360

tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg     3420

tggtgttgtc ggggaagctg acgtcctttc catggctgct cgcctgtgtt gccacctgga     3480

ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt     3540

cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga     3600

gtcggatctc cctttgggcc gcctccccgc c                                    3631


<210>  296
<211>  872
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a.TCR.WPRE amino acid sequence

<400>  296

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val Arg Ala Lys Arg Ser 
225                 230                 235                 240 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                245                 250                 255     


Glu Glu Asn Pro Gly Pro Met Asp Ser Trp Thr Phe Cys Cys Val Ser 
            260                 265                 270         


Leu Cys Ile Leu Val Ala Lys His Thr Asp Ala Gly Val Ile Gln Ser 
        275                 280                 285             


Pro Arg His Glu Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys 
    290                 295                 300                 


Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met 
305                 310                 315                 320 


Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile 
                325                 330                 335     


Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn 
            340                 345                 350         


Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser 
        355                 360                 365             


Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr 
    370                 375                 380                 


Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val 
385                 390                 395                 400 


Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser 
                405                 410                 415     


His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro 
            420                 425                 430         


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
        435                 440                 445             


Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn 
    450                 455                 460                 


Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe 
465                 470                 475                 480 


Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly 
                485                 490                 495     


Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr 
            500                 505                 510         


Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr 
        515                 520                 525             


Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu 
    530                 535                 540                 


Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu 
545                 550                 555                 560 


Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys 
                565                 570                 575     


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
            580                 585                 590         


Val Glu Glu Asn Pro Gly Pro Met Glu Lys Asn Pro Leu Ala Ala Pro 
        595                 600                 605             


Leu Leu Ile Leu Trp Phe His Leu Asp Cys Val Ser Ser Ile Leu Asn 
    610                 615                 620                 


Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr 
625                 630                 635                 640 


Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp 
                645                 650                 655     


Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr 
            660                 665                 670         


Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn 
        675                 680                 685             


Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu 
    690                 695                 700                 


Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg 
705                 710                 715                 720 


Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn Ile Gln Asn Pro 
                725                 730                 735     


Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser 
            740                 745                 750         


Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser 
        755                 760                 765             


Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg 
    770                 775                 780                 


Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser 
785                 790                 795                 800 


Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp 
                805                 810                 815     


Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu 
            820                 825                 830         


Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val 
        835                 840                 845             


Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
    850                 855                 860                 


Met Thr Leu Arg Leu Trp Ser Ser 
865                 870         


<210>  297
<211>  4419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8ba.TCR.WPRE nucleotide sequence

<400>  297
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg cgcccgagac tgtggcttct      420

gctcgccgcg caactgactg tcctgcacgg aaacagcgtg ctgcagcaga caccggccta      480

catcaaagtg cagaccaaca agatggtcat gctgtcctgc gaggccaaga tttccctctc      540

caacatgcgg atctattggt tgcggcagag acaggcgcct tcctcggact cccaccatga      600

gttcttggcc ctgtgggact ccgccaaggg aactattcac ggcgaagaag tggaacagga      660

gaagatcgcc gtgtttcgcg atgcctcccg ctttatactg aatctgacct ccgtgaagcc      720

cgaagatagc gggatctact tttgcatgat tgtgggctca cccgaactga ccttcgggaa      780

gggcactcag ctgagcgtgg tggacttcct ccccactacc gcccaaccca ctaagaagtc      840

aaccctgaag aagcgggttt gcagactccc acggccggaa acgcagaagg gtccgctgtg      900

ttccccgatc accctggggc tccttgtggc tggagtgctg gtccttctgg tgtcccttgg      960

cgtcgccatt cacctctgct gccggagaag gagggccaga ctgaggttca tgaagcagcc     1020

tcagggagag gggatcagtg gcactttcgt gccacaatgc ctccatggct actattccaa     1080

caccaccacc tcgcaaaagc tgctgaaccc ctggatcctg aaaacccggg ccaagagatc     1140

tggcagcggc gccaccaatt tcagcctgct gaaacaggcc ggcgacgtgg aagagaaccc     1200

tggccccatg gcgcttcccg tgaccgcact cctgttgccc cttgccctgc tgttgcacgc     1260

cgcacgacct tcccaattcc gggtgtcccc tctggatcgc acctggaacc tcggggaaac     1320

ggtggagctc aagtgtcaag tcctcctgtc gaacccgacc agcggatgca gctggctgtt     1380

ccagccgaga ggagctgccg cctcacccac cttcctcctg tacttgagcc agaacaagcc     1440

gaaggccgct gagggtctgg acacccagcg cttctcgggc aaacggctgg gagacacttt     1500

tgtgctgact ctctccgact tccggcggga gaacgagggc tactacttct gctctgcgct     1560

ctccaattca atcatgtact tctcacactt cgtgccggtg ttcctgcctg ccaagcccac     1620

cactactccg gcacccagac ctccaactcc cgctcccacc atcgcgtccc aacccctttc     1680

gctgcgccct gaagcgtgtc ggcctgctgc tggaggagcc gtgcataccc gcggtctgga     1740

cttcgcgtgc gacatctaca tttgggcccc tttggctggc acctgtggag tgctgctcct     1800

gtcccttgtg atcaccctgt actgcaacca ccggaatagg cggagagtct gcaagtgtcc     1860

gcggcctgtc gtgaagtcag gagataagcc gagcctgtcc gcacgctacg tgcgggccaa     1920

gagatctggc agcggcgagg gcagaggcag cctgctgacc tgcggcgacg tggaggagaa     1980

ccccggcccc atggactctt ggaccttctg ctgcgtgagc ctgtgcatcc tggtggccaa     2040

gcacacagac gccggcgtga tccagtcccc taggcacgag gtgaccgaga tgggccagga     2100

ggtgacactg cgctgtaagc caatctctgg ccacaacagc ctgttttggt atagggagac     2160

catgatgcgc ggcctggagc tgctgatcta cttcaataac aatgtgccca tcgacgattc     2220

cggcatgcct gaggatcggt tttctgccaa gatgcccaat gccagcttct ccacactgaa     2280

gatccagcct agcgagccaa gagactccgc cgtgtatttt tgcgcctcta gcccaggcag     2340

caccgataca cagtacttcg gaccaggaac caggctgaca gtgctggagg acctgaagaa     2400

cgtgttcccc cctgaggtgg ccgtgtttga gccctctgag gccgagatca gccacaccca     2460

gaaggccacc ctggtgtgcc tggcaaccgg cttctatcct gatcacgtgg agctgtcctg     2520

gtgggtgaac ggcaaggagg tgcacagcgg cgtgtccaca gacccacagc ccctgaagga     2580

gcagccagcc ctgaatgata gccggtattg cctgtcctct cggctgagag tgtccgccac     2640

cttttggcag aacccccgga atcacttcag atgtcaggtg cagttttacg gcctgtccga     2700

gaacgatgag tggacccagg accgggccaa gcctgtgaca cagatcgtgt ctgccgaggc     2760

atggggaaga gcagactgtg gcttcacctc tgagagctac cagcagggcg tgctgagcgc     2820

caccatcctg tatgagatcc tgctgggcaa ggccacactg tacgccgtcc tggtctccgc     2880

tctggtgctg atggcaatgg tcaaaagaaa agatagtcgg ggacgggcca agagatctgg     2940

cagcggccag tgcaccaact acgccctgct gaagctggcc ggcgacgtgg agagcaaccc     3000

cggccccatg gagaagaatc ccctggctgc ccccctgctg atcctgtggt ttcacctgga     3060

ctgcgtgtcc tctatcctga atgtggaaca gagcccacag agcctgcacg tgcaggaggg     3120

cgactccacc aacttcacat gctcttttcc tagctccaac ttctacgccc tgcactggta     3180

cagaaaggag accgcaaagt ccccagaggc cctgttcgtg atgacactga acggcgatga     3240

gaagaagaag ggccgcatca gcgccaccct gaatacaaag gagggctact cctatctgta     3300

catcaagggc tcccagcctg aggactctgc cacctatctg tgcgccctgt acaacaataa     3360

cgatatgcgg tttggcgccg gcaccagact gacagtgaag ccaaacatcc agaatccaga     3420

ccccgccgtg tatcagctgc gggacagcaa gtctagcgat aagagcgtgt gcctgttcac     3480

cgactttgat tctcagacaa acgtgagcca gtccaaggac agcgacgtgt acatcaccga     3540

caagacagtg ctggatatga gaagcatgga cttcaagtct aacagcgccg tggcctggtc     3600

caataagtct gatttcgcct gcgccaatgc ctttaataac tccatcatcc ccgaggatac     3660

cttctttcct tctccagagt cctcttgtga cgtgaagctg gtggagaagt ctttcgagac     3720

cgatacaaac ctgaattttc agaacctgag cgtgatcggc ttcaggatcc tgctgctgaa     3780

ggtggccggc tttaatctgc tgatgaccct gaggctgtgg agctcctgaa ccggtccgga     3840

gcatcttacc gccatttata cccatatttg ttctgttttt cttgatttgg gtatacattt     3900

aaatgttaat aaaacaaaat ggtggggcaa tcatttacat tttttgggat atgtaattac     3960

tagttcaggt gtattgccac aagacaaact tgttaagaaa ctttcccgtt atttacgctc     4020

tgttcctgtt aatcaacctc tggattacaa aatttgtgaa agattgactg atattcttaa     4080

ctttgttgct ccttttacgc tgtgtggatt tgctgcttta ttgcctctgt atcttgctat     4140

tgcttcccgt acggctttcg ttttctcctc cttgtataaa tcctggttgc tgtctctttt     4200

tgaggagttg tggcccgttg tccgtcaacg tggcgtggtg tgctctgtgt ttgctgacgc     4260

aacccccact ggctggggca ttgccaccac ctgtcaactc ctttctggga ctttcgcttt     4320

ccccctcccg atcgccacgg cagaactcat cgccgcctgc cttgcccgct gctggacagg     4380

ggctaggttg ctgggcactg ataattccgt ggtgttgtc                            4419


<210>  298
<211>  1143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8ba.TCR.WPRE amino acid sequence

<400>  298

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro 
        195                 200                 205             


Gln Gly Glu Gly Ile Ser Gly Thr Phe Val Pro Gln Cys Leu His Gly 
    210                 215                 220                 


Tyr Tyr Ser Asn Thr Thr Thr Ser Gln Lys Leu Leu Asn Pro Trp Ile 
225                 230                 235                 240 


Leu Lys Thr Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
                245                 250                 255     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
            260                 265                 270         


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
        275                 280                 285             


Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn 
    290                 295                 300                 


Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro 
305                 310                 315                 320 


Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser 
                325                 330                 335     


Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu 
            340                 345                 350         


Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe 
        355                 360                 365             


Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe 
    370                 375                 380                 


Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro 
385                 390                 395                 400 


Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                405                 410                 415     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            420                 425                 430         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        435                 440                 445             


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
    450                 455                 460                 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
465                 470                 475                 480 


Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp 
                485                 490                 495     


Lys Pro Ser Leu Ser Ala Arg Tyr Val Arg Ala Lys Arg Ser Gly Ser 
            500                 505                 510         


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
        515                 520                 525             


Pro Gly Pro Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile 
    530                 535                 540                 


Leu Val Ala Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His 
545                 550                 555                 560 


Glu Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile 
                565                 570                 575     


Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly 
            580                 585                 590         


Leu Glu Leu Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser 
        595                 600                 605             


Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe 
    610                 615                 620                 


Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr 
625                 630                 635                 640 


Phe Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro 
                645                 650                 655     


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
            660                 665                 670         


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
        675                 680                 685             


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
    690                 695                 700                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
705                 710                 715                 720 


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
                725                 730                 735     


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
            740                 745                 750         


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
        755                 760                 765             


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
    770                 775                 780                 


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
785                 790                 795                 800 


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
                805                 810                 815     


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
            820                 825                 830         


Ala Met Val Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg Ser Gly 
        835                 840                 845             


Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val 
    850                 855                 860                 


Glu Ser Asn Pro Gly Pro Met Glu Lys Asn Pro Leu Ala Ala Pro Leu 
865                 870                 875                 880 


Leu Ile Leu Trp Phe His Leu Asp Cys Val Ser Ser Ile Leu Asn Val 
                885                 890                 895     


Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn 
            900                 905                 910         


Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr 
        915                 920                 925             


Arg Lys Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu 
    930                 935                 940                 


Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr 
945                 950                 955                 960 


Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp 
                965                 970                 975     


Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe 
            980                 985                 990         


Gly Ala Gly Thr Arg Leu Thr Val  Lys Pro Asn Ile Gln  Asn Pro Asp 
        995                 1000                 1005             


Pro Ala  Val Tyr Gln Leu Arg  Asp Ser Lys Ser Ser  Asp Lys Ser 
    1010                 1015                 1020             


Val Cys  Leu Phe Thr Asp Phe  Asp Ser Gln Thr Asn  Val Ser Gln 
    1025                 1030                 1035             


Ser Lys  Asp Ser Asp Val Tyr  Ile Thr Asp Lys Thr  Val Leu Asp 
    1040                 1045                 1050             


Met Arg  Ser Met Asp Phe Lys  Ser Asn Ser Ala Val  Ala Trp Ser 
    1055                 1060                 1065             


Asn Lys  Ser Asp Phe Ala Cys  Ala Asn Ala Phe Asn  Asn Ser Ile 
    1070                 1075                 1080             


Ile Pro  Glu Asp Thr Phe Phe  Pro Ser Pro Glu Ser  Ser Cys Asp 
    1085                 1090                 1095             


Val Lys  Leu Val Glu Lys Ser  Phe Glu Thr Asp Thr  Asn Leu Asn 
    1100                 1105                 1110             


Phe Gln  Asn Leu Ser Val Ile  Gly Phe Arg Ile Leu  Leu Leu Lys 
    1115                 1120                 1125             


Val Ala  Gly Phe Asn Leu Leu  Met Thr Leu Arg Leu  Trp Ser Ser 
    1130                 1135                 1140             


<210>  299
<211>  7751
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR.WPRE nucleotide sequence

<400>  299
aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat       60

gttcttgctg cttcgcgatg tacgggccag atatacgcgt tgacattgat tattgactag      120

ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt      180

tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac      240

gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg      300

ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag      360

tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat      420

gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat      480

ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt      540

tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga      600

ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg      660

gtgggaggtc tatataagca gagctcgttt agtgaaccgg ggtctctctg gttagaccag      720

atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc      780

ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga      840

tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg aacagggact      900

tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt gctgaagcgc      960

gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg actagcggag     1020

gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga attagatcgc     1080

gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta aaacatatag     1140

tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta gaaacatcag     1200

aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga tcagaagaac     1260

ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg atagagataa     1320

aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt aagaccaccg     1380

cacagcaaga ggcctctgat cttcagacct ggaggaggag atatgaggga caattggaga     1440

agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc acccaccaag     1500

gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc tttgttcctt     1560

gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct gacggtacag     1620

gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag ggctattgag     1680

gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca ggcaagaatc     1740

ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg ttgctctgga     1800

aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa atctctggaa     1860

cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa ttacacaagc     1920

ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga acaagaatta     1980

ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa ttggctgtgg     2040

tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat agtttttgct     2100

gtactttcta tagtgaatag agttaggcag ggatattcac cattatcggt taacttttaa     2160

aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac     2220

agacatacaa actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttatcgatca     2280

cgagactagc ctcgaatctg cagaattcgc ccttatcgat tgaaagaccc cacctgtagg     2340

tttggcaagc tagcttaagt aacgccattt tgcaaggcat ggaaaataca taactgagaa     2400

tagagaagtt cagatcaagg ttaggaacag agagacagca gaatatgggc caaacaggat     2460

atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg     2520

gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct     2580

gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc     2640

gcgcttctgc tccccgagct caataaaaga gcccacaacc cctcactcag cggccgcccc     2700

gggtcgacgc taccaccatg gactcttgga ccttctgctg cgtgagcctg tgcatcctgg     2760

tggccaagca cacagacgcc ggcgtgatcc agtcccctag gcacgaggtg accgagatgg     2820

gccaggaggt gacactgcgc tgtaagccaa tctctggcca caacagcctg ttttggtata     2880

gggagaccat gatgcgcggc ctggagctgc tgatctactt caataacaat gtgcccatcg     2940

acgattccgg catgcctgag gatcggtttt ctgccaagat gcccaatgcc agcttctcca     3000

cactgaagat ccagcctagc gagccaagag actccgccgt gtatttttgc gcctctagcc     3060

caggcagcac cgatacacag tacttcggac caggaaccag gctgacagtg ctggaggacc     3120

tgaagaacgt gttcccccct gaggtggccg tgtttgagcc ctctgaggcc gagatcagcc     3180

acacccagaa ggccaccctg gtgtgcctgg caaccggctt ctatcctgat cacgtggagc     3240

tgtcctggtg ggtgaacggc aaggaggtgc acagcggcgt gtccacagac ccacagcccc     3300

tgaaggagca gccagccctg aatgatagcc ggtattgcct gtcctctcgg ctgagagtgt     3360

ccgccacctt ttggcagaac ccccggaatc acttcagatg tcaggtgcag ttttacggcc     3420

tgtccgagaa cgatgagtgg acccaggacc gggccaagcc tgtgacacag atcgtgtctg     3480

ccgaggcatg gggaagagca gactgtggct tcacctctga gagctaccag cagggcgtgc     3540

tgagcgccac catcctgtat gagatcctgc tgggcaaggc cacactgtac gccgtcctgg     3600

tctccgctct ggtgctgatg gcaatggtca aaagaaaaga tagtcgggga tctggcagcg     3660

gcgccaccaa tttcagcctg ctgaaacagg ccggcgacgt ggaagagaac cctggcccca     3720

tggagaagaa tcccctggct gcccccctgc tgatcctgtg gtttcacctg gactgcgtgt     3780

cctctatcct gaatgtggaa cagagcccac agagcctgca cgtgcaggag ggcgactcca     3840

ccaacttcac atgctctttt cctagctcca acttctacgc cctgcactgg tacagaaagg     3900

agaccgcaaa gtccccagag gccctgttcg tgatgacact gaacggcgat gagaagaaga     3960

agggccgcat cagcgccacc ctgaatacaa aggagggcta ctcctatctg tacatcaagg     4020

gctcccagcc tgaggactct gccacctatc tgtgcgccct gtacaacaat aacgatatgc     4080

ggtttggcgc cggcaccaga ctgacagtga agccaaacat ccagaatcca gaccccgccg     4140

tgtatcagct gcgggacagc aagtctagcg ataagagcgt gtgcctgttc accgactttg     4200

attctcagac aaacgtgagc cagtccaagg acagcgacgt gtacatcacc gacaagacag     4260

tgctggatat gagaagcatg gacttcaagt ctaacagcgc cgtggcctgg tccaataagt     4320

ctgatttcgc ctgcgccaat gcctttaata actccatcat ccccgaggat accttctttc     4380

cttctccaga gtcctcttgt gacgtgaagc tggtggagaa gtctttcgag accgatacaa     4440

acctgaattt tcagaacctg agcgtgatcg gcttcaggat cctgctgctg aaggtggccg     4500

gctttaatct gctgatgacc ctgaggctgt ggagctcctg aaccggtccg cagtctgacg     4560

tacgcgtaat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     4620

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     4680

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga     4740

ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac     4800

ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc     4860

cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     4920

tcggctgttg ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccatg     4980

gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc     5040

ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc     5100

gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcccgt     5160

acgtgtacat tacgcgccta ggatttaaat ccactcctga caactactct ttaatgcacg     5220

aggtgtcagt aggtgaagga gtcgtagttg tcgataagca gcaacatctt actacactgg     5280

tctcaactcc ggatccgagc tcggtacctt taagaccaat gacttacaag gcagctgtag     5340

atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa     5400

gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg     5460

agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc     5520

ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct     5580

tttagtcagt gtggaaaatc tctagcagca tctagagggc ccgtttaaac ccgctgatca     5640

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     5700

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     5760

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     5820

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctact     5880

gggcggtttt atggacagca agcgaaccgg aattgccagc tggggcgccc tctggtaagg     5940

ttgggaagcc ctgcaaagta aactggatgg ctttcttgcc gccaaggatc tgatggcgca     6000

ggggatcaag ctctgatcaa gagacaggat gaggatcgtt tcgcatgatt gaacaagatg     6060

gattgcacgc aggttctccg gccgcttggg tggagaggct attcggctat gactgggcac     6120

aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag gggcgcccgg     6180

ttctttttgt caagaccgac ctgtccggtg ccctgaatga actgcaagac gaggcagcgc     6240

ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac gttgtcactg     6300

aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc ctgtcatctc     6360

accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg ctgcatacgc     6420

ttgatccggc tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag cgagcacgta     6480

ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaagagcat caggggctcg     6540

cgccagccga actgttcgcc aggctcaagg cgagcatgcc cgacggcgag gatctcgtcg     6600

tgacccatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc ttttctggat     6660

tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg ttggctaccc     6720

gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg ctttacggta     6780

tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag ttcttctgaa     6840

ttattaacgc ttacaatttc ctgatgcggt attttctcct tacgcatctg tgcggtattt     6900

cacaccgcat caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     6960

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     7020

taatagcacg tgctaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt     7080

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc     7140

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     7200

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     7260

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg     7320

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     7380

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     7440

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     7500

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga     7560

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     7620

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     7680

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     7740

agcctatgga a                                                          7751


<210>  300
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR.WPRE amino acid sequence

<400>  300

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly Ser Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu 
                325                 330                 335     


Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His Leu Asp 
            340                 345                 350         


Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His 
        355                 360                 365             


Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser 
    370                 375                 380                 


Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro 
385                 390                 395                 400 


Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly 
                405                 410                 415     


Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr 
            420                 425                 430         


Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu 
        435                 440                 445             


Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val 
    450                 455                 460                 


Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
465                 470                 475                 480 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
                485                 490                 495     


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
            500                 505                 510         


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
        515                 520                 525             


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
    530                 535                 540                 


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
545                 550                 555                 560 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
                565                 570                 575     


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
            580                 585                 590         


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605         


<210>  301
<211>  3828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8aNCAM1Fusion.TCR.WPREmut2 nucleotide sequence

<400>  301
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gcgcttcccg tgaccgcact      420

cctgttgccc cttgccctgc tgttgcacgc cgcacgacct tcccaattcc gggtgtcccc      480

tctggatcgc acctggaacc tcggggaaac ggtggagctc aagtgtcaag tcctcctgtc      540

gaacccgacc agcggatgca gctggctgtt ccagccgaga ggagctgccg cctcacccac      600

cttcctcctg tacttgagcc agaacaagcc gaaggccgct gagggtctgg acacccagcg      660

cttctcgggc aaacggctgg gagacacttt tgtgctgact ctctccgact tccggcggga      720

gaacgagggc tactacttct gctctgcgct ctccaattca atcatgtact tctcacactt      780

cgtgccggtg ttcctgcctg ccagcgtggt ggacttcctc cccactaccg cccaacccac      840

taagaagtca accctgaaga agcgggtttg cagactccca cggccggaaa cgcagaaggg      900

tccgctgtgt tccccggcca tcgtgggcat cctgatcgtg atcttcgtgc tgctgctggt      960

ggtggtggac atcacctgct acttcctgaa caagtgcggc ctgttcatgt gcatcgccgt     1020

gaacctgtgc ggcaaggccg gccccggcgc caagggcaag gacatggagg agggcaaggc     1080

cgccttcagc aaggacgaga gcaaggagcc catcgtggag gtgaggaccg aggaggagag     1140

gacccccaac cacgacggcg gcaagcacac cgagcccaac gagaccaccc ccctgaccga     1200

gcccgagaag ggccccgtgg aggccaagcc cgagtgccag gagaccgaga ccaagcccgc     1260

ccccgccgag gtgaagaccg tgcccaacga cgccacccag accaaggaga acgagagcaa     1320

ggcccgggcc aagagatctg gcagcggcgc caccaatttc agcctgctga aacaggccgg     1380

cgacgtggaa gagaaccctg gccccatgga ctcttggacc ttctgctgcg tgagcctgtg     1440

catcctggtg gccaagcaca cagacgccgg cgtgatccag tcccctaggc acgaggtgac     1500

cgagatgggc caggaggtga cactgcgctg taagccaatc tctggccaca acagcctgtt     1560

ttggtatagg gagaccatga tgcgcggcct ggagctgctg atctacttca ataacaatgt     1620

gcccatcgac gattccggca tgcctgagga tcggttttct gccaagatgc ccaatgccag     1680

cttctccaca ctgaagatcc agcctagcga gccaagagac tccgccgtgt atttttgcgc     1740

ctctagccca ggcagcaccg atacacagta cttcggacca ggaaccaggc tgacagtgct     1800

ggaggacctg aagaacgtgt tcccccctga ggtggccgtg tttgagccct ctgaggccga     1860

gatcagccac acccagaagg ccaccctggt gtgcctggca accggcttct atcctgatca     1920

cgtggagctg tcctggtggg tgaacggcaa ggaggtgcac agcggcgtgt ccacagaccc     1980

acagcccctg aaggagcagc cagccctgaa tgatagccgg tattgcctgt cctctcggct     2040

gagagtgtcc gccacctttt ggcagaaccc ccggaatcac ttcagatgtc aggtgcagtt     2100

ttacggcctg tccgagaacg atgagtggac ccaggaccgg gccaagcctg tgacacagat     2160

cgtgtctgcc gaggcatggg gaagagcaga ctgtggcttc acctctgaga gctaccagca     2220

gggcgtgctg agcgccacca tcctgtatga gatcctgctg ggcaaggcca cactgtacgc     2280

cgtcctggtc tccgctctgg tgctgatggc aatggtcaaa agaaaagata gtcggggacg     2340

ggccaagaga tctggcagcg gcgagggcag aggcagcctg ctgacctgcg gcgacgtgga     2400

ggagaacccc ggccccatgg agaagaatcc cctggctgcc cccctgctga tcctgtggtt     2460

tcacctggac tgcgtgtcct ctatcctgaa tgtggaacag agcccacaga gcctgcacgt     2520

gcaggagggc gactccacca acttcacatg ctcttttcct agctccaact tctacgccct     2580

gcactggtac agaaaggaga ccgcaaagtc cccagaggcc ctgttcgtga tgacactgaa     2640

cggcgatgag aagaagaagg gccgcatcag cgccaccctg aatacaaagg agggctactc     2700

ctatctgtac atcaagggct cccagcctga ggactctgcc acctatctgt gcgccctgta     2760

caacaataac gatatgcggt ttggcgccgg caccagactg acagtgaagc caaacatcca     2820

gaatccagac cccgccgtgt atcagctgcg ggacagcaag tctagcgata agagcgtgtg     2880

cctgttcacc gactttgatt ctcagacaaa cgtgagccag tccaaggaca gcgacgtgta     2940

catcaccgac aagacagtgc tggatatgag aagcatggac ttcaagtcta acagcgccgt     3000

ggcctggtcc aataagtctg atttcgcctg cgccaatgcc tttaataact ccatcatccc     3060

cgaggatacc ttctttcctt ctccagagtc ctcttgtgac gtgaagctgg tggagaagtc     3120

tttcgagacc gatacaaacc tgaattttca gaacctgagc gtgatcggct tcaggatcct     3180

gctgctgaag gtggccggct ttaatctgct gatgaccctg aggctgtgga gctcctgaac     3240

cggtccggag catcttaccg ccatttatac ccatatttgt tctgtttttc ttgatttggg     3300

tatacattta aatgttaata aaacaaaatg gtggggcaat catttacatt ttttgggata     3360

tgtaattact agttcaggtg tattgccaca agacaaactt gttaagaaac tttcccgtta     3420

tttacgctct gttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactga     3480

tattcttaac tttgttgctc cttttacgct gtgtggattt gctgctttat tgcctctgta     3540

tcttgctatt gcttcccgta cggctttcgt tttctcctcc ttgtataaat cctggttgct     3600

gtctcttttt gaggagttgt ggcccgttgt ccgtcaacgt ggcgtggtgt gctctgtgtt     3660

tgctgacgca acccccactg gctggggcat tgccaccacc tgtcaactcc tttctgggac     3720

tttcgctttc cccctcccga tcgccacggc agaactcatc gccgcctgcc ttgcccgctg     3780

ctggacaggg gctaggttgc tgggcactga taattccgtg gtgttgtc                  3828


<210>  302
<211>  946
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8aNCAM1Fusion.TCR.WPREmut2 amino acid sequence

<400>  302

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Ser Val Val Asp Phe Leu Pro Thr Thr 
    130                 135                 140                 


Ala Gln Pro Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu 
145                 150                 155                 160 


Pro Arg Pro Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ala Ile Val 
                165                 170                 175     


Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile 
            180                 185                 190         


Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val 
        195                 200                 205             


Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu 
    210                 215                 220                 


Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val 
225                 230                 235                 240 


Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys 
                245                 250                 255     


His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly 
            260                 265                 270         


Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala 
        275                 280                 285             


Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu 
    290                 295                 300                 


Asn Glu Ser Lys Ala Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn 
305                 310                 315                 320 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                325                 330                 335     


Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
            340                 345                 350         


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        355                 360                 365             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    370                 375                 380                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu 
385                 390                 395                 400 


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
                405                 410                 415     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
            420                 425                 430         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        435                 440                 445             


Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
    450                 455                 460                 


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
465                 470                 475                 480 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
                485                 490                 495     


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
            500                 505                 510         


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
        515                 520                 525             


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
    530                 535                 540                 


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
545                 550                 555                 560 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
                565                 570                 575     


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
            580                 585                 590         


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
        595                 600                 605             


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
    610                 615                 620                 


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
625                 630                 635                 640 


Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg Ser Gly Ser Gly Glu 
                645                 650                 655     


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
            660                 665                 670         


Pro Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe 
        675                 680                 685             


His Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln 
    690                 695                 700                 


Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe 
705                 710                 715                 720 


Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr Ala 
                725                 730                 735     


Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys 
            740                 745                 750         


Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser 
        755                 760                 765             


Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu 
    770                 775                 780                 


Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg 
785                 790                 795                 800 


Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
                805                 810                 815     


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
            820                 825                 830         


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
        835                 840                 845             


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
    850                 855                 860                 


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
865                 870                 875                 880 


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
                885                 890                 895     


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
            900                 905                 910         


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
        915                 920                 925             


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
    930                 935                 940                 


Ser Ser 
945     


<210>  303
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11P3D3KE beta chain

<400>  303

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  304
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R39P1C12 alpha chain

<400>  304

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ile Asp Asn Gln Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu 
        115                 120                 125             


Ser Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


