                         SEQUENCE LISTING

<110>  CHAN ZUCKERBERG BIOHUB, INC.
       THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120>  AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY

<130>  103182-1277216-006310WO

<150>  US 63/131,255
<151>  2020-12-28

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Val Asn Lys Gly Leu Thr Leu Leu Asp Gly Asp Leu Pro Glu 
1               5                   10                  15      


Gln Glu Asn Val Leu Gln Arg Val Leu Gln Leu Pro Val Val Ser Gly 
            20                  25                  30          


Thr Cys Glu Cys Phe Gln Lys Thr Tyr Thr Ser Thr Lys Glu Ala His 
        35                  40                  45              


Pro Leu Val Ala Ser Val Cys Asn Ala Tyr Glu Lys Gly Val Gln Ser 
    50                  55                  60                  


Ala Ser Ser Leu Ala Ala Trp Ser Met Glu Pro Val Val Arg Arg Leu 
65                  70                  75                  80  


Ser Thr Gln Phe Thr Ala Ala Asn Glu Leu Ala Cys Arg Gly Leu Asp 
                85                  90                  95      


His Leu Glu Glu Lys Ile Pro Ala Leu Gln Tyr Pro Pro Glu Lys Ile 
            100                 105                 110         


Ala Ser Glu Leu Lys Asp Thr Ile Ser Thr Arg Leu Arg Ser Ala Arg 
        115                 120                 125             


Asn Ser Ile Ser Val Pro Ile Ala Ser Thr Ser Asp Lys Val Leu Gly 
    130                 135                 140                 


Ala Ala Leu Ala Gly Cys Glu Leu Ala Trp Gly Val Ala Arg Asp Thr 
145                 150                 155                 160 


Ala Glu Phe Ala Ala Asn Thr Arg Ala Gly Arg Leu Ala Ser Gly Gly 
                165                 170                 175     


Ala Asp Leu Ala Leu Gly Ser Ile Glu Lys Val Val Glu Tyr Leu Leu 
            180                 185                 190         


Pro Pro Asp Lys Glu Glu Ser Ala Pro Ala Pro Gly His Gln Gln Ala 
        195                 200                 205             


Gln Lys Ser Pro Lys Ala Lys Pro Ser Leu Leu Ser Arg Val Gly Ala 
    210                 215                 220                 


Leu Thr Asn Thr Leu Ser Arg Tyr Thr Val Gln Thr Met Ala Arg Ala 
225                 230                 235                 240 


Leu Glu Gln Gly His Thr Val Ala Met Trp Ile Pro Gly Val Val Pro 
                245                 250                 255     


Leu Ser Ser Leu Ala Gln Trp Gly Ala Ser Val Ala Met Gln Ala Val 
            260                 265                 270         


Ser Arg Arg Arg Ser Glu Val Arg Val Pro Trp Leu His Ser Leu Ala 
        275                 280                 285             


Ala Ala Gln Glu Glu Asp His Glu Asp Gln Thr Asp Thr Glu Gly Glu 
    290                 295                 300                 


Asp Thr Glu Glu Glu Glu Glu Leu Glu Thr Glu Glu Asn Lys Phe Ser 
305                 310                 315                 320 


Glu Val Ala Ala Leu Pro Gly Pro Arg Gly Leu Leu Gly Gly Val Ala 
                325                 330                 335     


His Thr Leu Gln Lys Thr Leu Gln Thr Thr Ile Ser Ala Val Thr Trp 
            340                 345                 350         


Ala Pro Ala Ala Val Leu Gly Met Ala Gly Arg Val Leu His Leu Thr 
        355                 360                 365             


Pro Ala Pro Ala Val Ser Ser Thr Lys Gly Arg Ala Met Ser Leu Ser 
    370                 375                 380                 


Asp Ala Leu Lys Gly Val Thr Asp Asn Val Val Asp Thr Val Val His 
385                 390                 395                 400 


Tyr Val Pro Leu Pro Arg Leu Ser Leu Met Glu Pro Glu Ser Glu Phe 
                405                 410                 415     


Arg Asp Ile Asp Asn Pro Pro Ala Glu Val Glu Arg Arg Glu Ala Glu 
            420                 425                 430         


Arg Arg Ala Ser Gly Ala Pro Ser Ala Gly Pro Glu Pro Ala Pro Arg 
        435                 440                 445             


Leu Ala Gln Pro Arg Arg Ser Leu Arg Ser Ala Gln Ser Pro Gly Ala 
    450                 455                 460                 


Pro Pro Gly Pro Gly Leu Glu Asp Glu Val Ala Thr Pro Ala Ala Pro 
465                 470                 475                 480 


Arg Pro Gly Phe Pro Ala Val Pro Arg Glu Lys Pro Lys Arg Arg Val 
                485                 490                 495     


Ser Asp Ser Phe Phe Arg Pro Ser Val Met Glu Pro Ile Leu Gly Arg 
            500                 505                 510         


Thr His Tyr Ser Gln Leu Arg Lys Lys Ser 
        515                 520         


<210>  2
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Gln Leu Pro Val Val Ser Gly Thr Cys Glu Cys Phe Gln Lys Thr 
1               5                   10                  15      


Tyr Thr Ser Thr Lys Glu Ala His Pro Leu Val Ala Ser Val Cys Asn 
            20                  25                  30          


Ala Tyr Glu Lys Gly Val Gln Ser Ala Ser Ser Leu Ala Ala Trp Ser 
        35                  40                  45              


Met 
    


<210>  3
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Leu Val Ala Ser Val Cys Asn Ala Tyr Glu Lys Gly Val Gln Ser 
1               5                   10                  15      


Ala Ser Ser Leu Ala Ala Trp Ser Met Glu Pro Val Val Arg Arg Leu 
            20                  25                  30          


Ser Thr Gln Phe Thr Ala Ala Asn Glu Leu Ala Cys Arg Gly Leu Asp 
        35                  40                  45              


His 
    


<210>  4
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Ser Val Ala Met Gln Ala Val Ser Arg Arg Arg Ser Glu Val Arg 
1               5                   10                  15      


Val Pro Trp Leu His Ser Leu Ala Ala Ala Gln Glu Glu Asp His Glu 
            20                  25                  30          


Asp Gln Thr Asp Thr Glu Gly Glu Asp Thr Glu Glu Glu Glu Glu Leu 
        35                  40                  45              


Glu 
    


<210>  5
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  5

His Leu Glu Glu Lys Ile Pro Ala Leu Gln Tyr Pro Pro Glu Lys Ile 
1               5                   10                  15      


Ala Ser Glu Leu Lys Asp Thr Ile Ser Thr Arg Leu Arg Ser Ala Arg 
            20                  25                  30          


Asn Ser Ile Ser Val Pro Ile Ala Ser Thr Ser Asp Lys Val Leu Gly 
        35                  40                  45              


Ala 
    


<210>  6
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Thr Arg Leu Arg Ser Ala Arg Asn Ser Ile Ser Val Pro Ile Ala 
1               5                   10                  15      


Ser Thr Ser Asp Lys Val Leu Gly Ala Ala Leu Ala Gly Cys Glu Leu 
            20                  25                  30          


Ala Trp Gly Val Ala Arg Asp Thr Ala Glu Phe Ala Ala Asn Thr Arg 
        35                  40                  45              


Ala 
    


<210>  7
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Val Asn Lys Gly Leu Thr Leu Leu Asp Gly Asp Leu Pro Glu 
1               5                   10                  15      


Gln Glu Asn Val Leu Gln Arg Val Leu Gln Leu Pro Val Val Ser Gly 
            20                  25                  30          


Thr Cys Glu Cys Phe Gln Lys Thr Tyr Thr Ser Thr Lys Glu Ala His 
        35                  40                  45              


Pro 
    


<210>  8
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Pro Val Val Arg Arg Leu Ser Thr Gln Phe Thr Ala Ala Asn 
1               5                   10                  15      


Glu Leu Ala Cys Arg Gly Leu Asp His Leu Glu Glu Lys Ile Pro Ala 
            20                  25                  30          


Leu Gln Tyr Pro Pro Glu Lys Ile Ala Ser Glu Leu Lys Asp Thr Ile 
        35                  40                  45              


Ser 
    


<210>  9
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Ala Leu Ala Gly Cys Glu Leu Ala Trp Gly Val Ala Arg Asp Thr 
1               5                   10                  15      


Ala Glu Phe Ala Ala Asn Thr Arg Ala Gly Arg Leu Ala Ser Gly Gly 
            20                  25                  30          


Ala Asp Leu Ala Leu Gly Ser Ile Glu Lys Val Val Glu Tyr Leu Leu 
        35                  40                  45              


Pro 
    


<210>  10
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Gly Arg Leu Ala Ser Gly Gly Ala Asp Leu Ala Leu Gly Ser Ile 
1               5                   10                  15      


Glu Lys Val Val Glu Tyr Leu Leu Pro Pro Asp Lys Glu Glu Ser Ala 
            20                  25                  30          


Pro Ala Pro Gly His Gln Gln Ala Gln Lys Ser Pro Lys Ala Lys Pro 
        35                  40                  45              


Ser 
    


<210>  11
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Pro Asp Lys Glu Glu Ser Ala Pro Ala Pro Gly His Gln Gln Ala 
1               5                   10                  15      


Gln Lys Ser Pro Lys Ala Lys Pro Ser Leu Leu Ser Arg Val Gly Ala 
            20                  25                  30          


Leu Thr Asn Thr Leu Ser Arg Tyr Thr Val Gln Thr Met Ala Arg Ala 
        35                  40                  45              


Leu 
    


<210>  12
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Leu Leu Ser Arg Val Gly Ala Leu Thr Asn Thr Leu Ser Arg Tyr 
1               5                   10                  15      


Thr Val Gln Thr Met Ala Arg Ala Leu Glu Gln Gly His Thr Val Ala 
            20                  25                  30          


Met Trp Ile Pro Gly Val Val Pro Leu Ser Ser Leu Ala Gln Trp Gly 
        35                  40                  45              


Ala 
    


<210>  13
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Glu Gln Gly His Thr Val Ala Met Trp Ile Pro Gly Val Val Pro 
1               5                   10                  15      


Leu Ser Ser Leu Ala Gln Trp Gly Ala Ser Val Ala Met Gln Ala Val 
            20                  25                  30          


Ser Arg Arg Arg Ser Glu Val Arg Val Pro Trp Leu His Ser Leu Ala 
        35                  40                  45              


Ala 
    


<210>  14
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Ala Gln Glu Glu Asp His Glu Asp Gln Thr Asp Thr Glu Gly Glu 
1               5                   10                  15      


Asp Thr Glu Glu Glu Glu Glu Leu Glu Thr Glu Glu Asn Lys Phe Ser 
            20                  25                  30          


Glu Val Ala Ala Leu Pro Gly Pro Arg Gly Leu Leu Gly Gly Val Ala 
        35                  40                  45              


His 
    


<210>  15
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Thr Glu Glu Asn Lys Phe Ser Glu Val Ala Ala Leu Pro Gly Pro 
1               5                   10                  15      


Arg Gly Leu Leu Gly Gly Val Ala His Thr Leu Gln Lys Thr Leu Gln 
            20                  25                  30          


Thr Thr Ile Ser Ala Val Thr Trp Ala Pro Ala Ala Val Leu Gly Met 
        35                  40                  45              


Ala 
    


<210>  16
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  16

His Thr Leu Gln Lys Thr Leu Gln Thr Thr Ile Ser Ala Val Thr Trp 
1               5                   10                  15      


Ala Pro Ala Ala Val Leu Gly Met Ala Gly Arg Val Leu His Leu Thr 
            20                  25                  30          


Pro Ala Pro Ala Val Ser Ser Thr Lys Gly Arg Ala Met Ser Leu Ser 
        35                  40                  45              


Asp 
    


<210>  17
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Gly Arg Val Leu His Leu Thr Pro Ala Pro Ala Val Ser Ser Thr 
1               5                   10                  15      


Lys Gly Arg Ala Met Ser Leu Ser Asp Ala Leu Lys Gly Val Thr Asp 
            20                  25                  30          


Asn Val Val Asp Thr Val Val His Tyr Val Pro Leu Pro Arg Leu Ser 
        35                  40                  45              


Leu 
    


<210>  18
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Ala Leu Lys Gly Val Thr Asp Asn Val Val Asp Thr Val Val His 
1               5                   10                  15      


Tyr Val Pro Leu Pro Arg Leu Ser Leu Met Glu Pro Glu Ser Glu Phe 
            20                  25                  30          


Arg Asp Ile Asp Asn Pro Pro Ala Glu Val Glu Arg Arg Glu Ala Glu 
        35                  40                  45              


Arg 
    


<210>  19
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  19

Leu Met Glu Pro Glu Ser Glu Phe Arg Asp Ile Asp Asn Pro Pro Ala 
1               5                   10                  15      


Glu Val Glu Arg Arg Glu Ala Glu Arg Arg Ala Ser Gly Ala Pro Ser 
            20                  25                  30          


Ala Gly Pro Glu Pro Ala Pro Arg Leu Ala Gln Pro Arg Arg Ser Leu 
        35                  40                  45              


Arg 
    


<210>  20
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Arg Ala Ser Gly Ala Pro Ser Ala Gly Pro Glu Pro Ala Pro Arg 
1               5                   10                  15      


Leu Ala Gln Pro Arg Arg Ser Leu Arg Ser Ala Gln Ser Pro Gly Ala 
            20                  25                  30          


Pro Pro Gly Pro Gly Leu Glu Asp Glu Val Ala Thr Pro Ala Ala Pro 
        35                  40                  45              


Arg 
    


<210>  21
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  21

Arg Ser Ala Gln Ser Pro Gly Ala Pro Pro Gly Pro Gly Leu Glu Asp 
1               5                   10                  15      


Glu Val Ala Thr Pro Ala Ala Pro Arg Pro Gly Phe Pro Ala Val Pro 
            20                  25                  30          


Arg Glu Lys Pro Lys Arg Arg Val Ser Asp Ser Phe Phe Arg Pro Ser 
        35                  40                  45              


Val 
    


<210>  22
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Pro Gly Phe Pro Ala Val Pro Arg Glu Lys Pro Lys Arg Arg Val 
1               5                   10                  15      


Ser Asp Ser Phe Phe Arg Pro Ser Val Met Glu Pro Ile Leu Gly Arg 
            20                  25                  30          


Thr His Tyr Ser Gln Leu Arg Lys Lys Ser 
        35                  40          


<210>  23
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  23

Val Met Glu Pro Ile Leu Gly Arg Thr His Tyr Ser Gln Leu Arg Lys 
1               5                   10                  15      


Lys Ser 
        


