                         SEQUENCE LISTING

<110>  Janssen Pharmaceuticals, Inc.
       Arcturus Therapeutics, Inc.
 
<120>  Transcription Activator-like Effector Nucleases (TALENs) 
       Targeting HBV

<130>  065814.11515/45WO1

<150>  63/131,145
<151>  2020-12-28

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE 28 Left DNA binding target

<400>  1
tgctgctatg cctcatcttc                                                   20


<210>  2
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE 28 Right DNA binding target

<400>  2
ctggactatc aaggta                                                       16


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE 33 Left DNA binding target

<400>  3
tcctgctgct atgcctcat                                                    19


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE 33 Right DNA binding target

<400>  4
cttctggact atcaaggta                                                    19


<210>  5
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE 28 DNA binding target

<400>  5
tgctgctatg cctcatcttc ttgttggttc ttctggacta tcaaggta                    48


<210>  6
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE 33 DNA binding target

<400>  6
tcctgctgct atgcctcatc ttcttattgg ttcttctgga ctatcaaggt a                51


<210>  7
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALE 28 Left DNA binding sequence

<400>  7

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
            340                 345                 350         


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    530                 535                 540                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
545                 550                 555                 560 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                565                 570                 575     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
            580                 585                 590         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        595                 600                 605             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
    610                 615                 620                 


Asp Gly Gly 
625         


<210>  8
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALE 28 Right DNA binding sequence

<400>  8

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
65                  70                  75                  80  


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
                485                 490     


<210>  9
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALE 33 Left DNA binding sequence

<400>  9

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    530                 535                 540                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
545                 550                 555                 560 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                565                 570                 575     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
            580                 585                 590         


Gly 
    


<210>  10
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALE 33 Right DNA binding sequence

<400>  10

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
65                  70                  75                  80  


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    530                 535                 540                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
545                 550                 555                 560 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                565                 570                 575     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
            580                 585                 590         


Gly 
    


<210>  11
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FokI Nuclease

<400>  11

Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe Arg Ser 
        195             


<210>  12
<211>  129
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TEV 5'UTR

<400>  12
ucaacacaac auauacaaaa caaacgaauc ucaagcaauc aagcauucua cuucuauugc       60

agcaauuuaa aucauuucuu uuaaagcaaa agcaauuuuc ugaaaauuuu caccauuuac      120

gaacgauag                                                              129


<210>  13
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AT1G58420 5'UTR

<400>  13
auuauuacau caaaacaaaa agccgcca                                          28


<210>  14
<211>  245
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ARC5-2 5'UTR

<400>  14
cuuaaggggg cgcugccuac ggagguggca gccaucuccu ucucggcauc aagcuuacca       60

uggugcccca ggcccugcuc uuggucccgc ugcugguguu cccccucugc uucggcaagu      120

uccccaucua caccaucccc gacaagcugg ggccguggag ccccaucgac auccaccacc      180

uguccugccc caacaaccuc guggucgagg acgagggcug caccaaccug agcggguucu      240

ccuac                                                                  245


<210>  15
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HCV 5'UTR

<400>  15
ugagugucgu acagccucca ggcccccccc ucccgggaga gccauagugg ucugcggaac       60

cggugaguac accggaauug ccgggaagac uggguccuuu cuuggauaaa cccacucuau      120

gcccggccau uugggcgugc ccccgcaaga cugcuagccg aguaguguug gguugcg         177


<210>  16
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human Albumin 5'UTR

<400>  16
aauuauuggu uaaagaagua uauuagugcu aauuucccuc cguuuguccu agcuuuucuc       60

uucugucaac cccacacgcc uuuggcaca                                         89


<210>  17
<211>  569
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  EMCV 5'UTR

<400>  17
cucccucccc ccccccuaac guuacuggcc gaagccgcuu ggaauaaggc cggugugcgu       60

uugucuauau guuauuuucc accauauugc cgucuuuugg caaugugagg gcccggaaac      120

cuggcccugu cuucuugacg agcauuccua ggggucuuuc cccucucgcc aaaggaaugc      180

aaggucuguu gaaugucgug aaggaagcag uuccucugga agcuucuuga agacaaacaa      240

cgucuguagc gacccuuugc aggcagcgga accccccacc uggcgacagg ugccucugcg      300

gccaaaagcc acguguauaa gauacaccug caaaggcggc acaaccccag ugccacguug      360

ugaguuggau aguuguggaa agagucaaau ggcucuccuc aagcguauuc aacaaggggc      420

ugaaggaugc ccagaaggua ccccauugua ugggaucuga ucuggggccu cggugcacau      480

gcuuuacgug uguuuagucg agguuaaaaa acgucuaggc cccccgaacc acggggacgu      540

gguuuuccuu ugaaaaacac gaugauaau                                        569


<210>  18
<211>  158
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  XBG 3'UTR

<400>  18
cuagugacug acuaggaucu gguuaccacu aaaccagccu caagaacacc cgaauggagu       60

cucuaagcua cauaauacca acuuacacuu acaaaauguu gucccccaaa auguagccau      120

ucguaucugc uccuaauaaa aagaaaguuu cuucacau                              158


<210>  19
<211>  166
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human haptoglobin 3'UTR

<400>  19
ugcaaggcug gccggaagcc cuugccugaa agcaagauuu cagccuggaa gagggcaaag       60

uggacgggag uggacaggag uggaugcgau aagauguggu uugaagcuga ugggugccag      120

cccugcauug cugagucaau caauaaagag cuuucuuuug acccau                     166


<210>  20
<211>  143
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human Apolipoprotein E 3'UTR

<400>  20
acgccgaagc cugcagccau gcgaccccac gccaccccgu gccuccugcc uccgcgcagc       60

cugcagcggg agacccuguc cccgccccag ccguccuccu gggguggacc cuaguuuaau      120

aaagauucac caaguuucac gca                                              143


<210>  21
<211>  220
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HCV 3'UTR

<400>  21
uagagcggca aacccuagcu acacuccaua gcuaguuucu uuuuuuuuug uuuuuuuuuu       60

uuuuuuuuuu uuuuuuuuuu uuuuuuuuuc cuuucuuuuc cuucuuuuuu uccucuuuuc      120

uugguggcuc caucuuagcc cuagucacgg cuagcuguga aagguccgug agccgcauga      180

cugcagagag ugccguaacu ggucucucug cagaucaugu                            220


<210>  22
<211>  170
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse albumin 3'UTR

<400>  22
acacaucaca accacaaccu ucucaggcua cccugagaaa aaaagacaug aagacucagg       60

acucaucuuu ucuguuggug uaaaaucaac acccuaagga acacaaauuu cuuuaaacau      120

uugacuucuu gucucugugc ugcaauuaau aaaaaaugga aagaaucuac                 170


<210>  23
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human alpha globin 3'UTR

<400>  23
gcuggagccu cgguagccgu uccuccugcc cgcugggccu cccaacgggc ccuccucccc       60

uccuugcacc ggcccuuccu ggucuuugaa uaaagucuga gugggcagca                 110


<210>  24
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  EMCV 3'UTR

<400>  24
uagugcaguc acuggcacaa cgcguugccc gguaagccaa ucggguauac acggucguca       60

uacugcagac aggguucuuc uacuuugcaa gauagucuag aguaguaaaa uaaauaguau      120

aag                                                                    123


<210>  25
<211>  1073
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALEN 28 Left protein

<400>  25

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Gly Gly Ser Gly Pro Lys Lys Lys Arg 
            20                  25                  30          


Lys Val Gly Ile His Gly Val Pro Ala Ala Val Asp Leu Arg Thr Leu 
        35                  40                  45              


Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser 
    50                  55                  60                  


Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His 
65                  70                  75                  80  


Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val 
                85                  90                  95      


Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His 
            100                 105                 110         


Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu 
        115                 120                 125             


Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln 
    130                 135                 140                 


Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr 
145                 150                 155                 160 


Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro 
                165                 170                 175     


Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
            180                 185                 190         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        195                 200                 205             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
    210                 215                 220                 


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
225                 230                 235                 240 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                245                 250                 255     


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            260                 265                 270         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        275                 280                 285             


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    290                 295                 300                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
305                 310                 315                 320 


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
                325                 330                 335     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            340                 345                 350         


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
        355                 360                 365             


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    370                 375                 380                 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
385                 390                 395                 400 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                405                 410                 415     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
            420                 425                 430         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        435                 440                 445             


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
    450                 455                 460                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
465                 470                 475                 480 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
                485                 490                 495     


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            500                 505                 510         


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
        515                 520                 525             


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    530                 535                 540                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
545                 550                 555                 560 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                565                 570                 575     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            580                 585                 590         


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
        595                 600                 605             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
    610                 615                 620                 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
625                 630                 635                 640 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                645                 650                 655     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
            660                 665                 670         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        675                 680                 685             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    690                 695                 700                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
705                 710                 715                 720 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
                725                 730                 735     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            740                 745                 750         


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
        755                 760                 765             


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    770                 775                 780                 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
785                 790                 795                 800 


Ser His Asp Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu 
                805                 810                 815     


Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val 
            820                 825                 830         


Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys 
        835                 840                 845             


Gly Leu Pro His Ala Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile 
    850                 855                 860                 


Pro Glu Arg Thr Ser His Arg Val Ala Gly Ser Gln Leu Val Lys Ser 
865                 870                 875                 880 


Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val 
                885                 890                 895     


Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln 
            900                 905                 910         


Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr 
        915                 920                 925             


Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala 
    930                 935                 940                 


Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr 
945                 950                 955                 960 


Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu 
                965                 970                 975     


Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn 
            980                 985                 990         


Pro Asn Glu Trp Trp Lys Val Tyr  Pro Ser Ser Val Thr  Glu Phe Lys 
        995                 1000                 1005             


Phe Leu  Phe Val Ser Gly His  Phe Lys Gly Asn Tyr  Lys Ala Gln 
    1010                 1015                 1020             


Leu Thr  Arg Leu Asn His Ile  Thr Asn Cys Asn Gly  Ala Val Leu 
    1025                 1030                 1035             


Ser Val  Glu Glu Leu Leu Ile  Gly Gly Glu Met Ile  Lys Ala Gly 
    1040                 1045                 1050             


Thr Leu  Thr Leu Glu Glu Val  Arg Arg Lys Phe Asn  Asn Gly Glu 
    1055                 1060                 1065             


Ile Asn  Phe Arg Ser 
    1070             


<210>  26
<211>  937
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALEN 28 Right protein

<400>  26

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Gly Gly Ser Gly Pro Lys Lys Lys Arg 
            20                  25                  30          


Lys Val Gly Ile His Gly Val Pro Ala Ala Val Asp Leu Arg Thr Leu 
        35                  40                  45              


Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser 
    50                  55                  60                  


Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His 
65                  70                  75                  80  


Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val 
                85                  90                  95      


Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His 
            100                 105                 110         


Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu 
        115                 120                 125             


Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln 
    130                 135                 140                 


Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr 
145                 150                 155                 160 


Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro 
                165                 170                 175     


Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
            180                 185                 190         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        195                 200                 205             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
    210                 215                 220                 


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
225                 230                 235                 240 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                245                 250                 255     


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            260                 265                 270         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        275                 280                 285             


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    290                 295                 300                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
305                 310                 315                 320 


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
                325                 330                 335     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            340                 345                 350         


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
        355                 360                 365             


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    370                 375                 380                 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
385                 390                 395                 400 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                405                 410                 415     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
            420                 425                 430         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        435                 440                 445             


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
    450                 455                 460                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
465                 470                 475                 480 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
                485                 490                 495     


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            500                 505                 510         


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
        515                 520                 525             


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    530                 535                 540                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
545                 550                 555                 560 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                565                 570                 575     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            580                 585                 590         


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
        595                 600                 605             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
    610                 615                 620                 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
625                 630                 635                 640 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                645                 650                 655     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Arg Pro Ala 
            660                 665                 670         


Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala 
        675                 680                 685             


Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg 
    690                 695                 700                 


Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Ala Leu 
705                 710                 715                 720 


Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr Ser His Arg Val 
                725                 730                 735     


Ala Gly Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu 
            740                 745                 750         


Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile 
        755                 760                 765             


Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val 
    770                 775                 780                 


Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly 
785                 790                 795                 800 


Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile 
                805                 810                 815     


Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn 
            820                 825                 830         


Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn 
        835                 840                 845             


Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr 
    850                 855                 860                 


Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe 
865                 870                 875                 880 


Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn 
                885                 890                 895     


Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu 
            900                 905                 910         


Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe 
        915                 920                 925             


Asn Asn Gly Glu Ile Asn Phe Arg Ser 
    930                 935         


<210>  27
<211>  1039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALEN 33 Left protein

<400>  27

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Gly Gly Ser Gly Pro Lys Lys Lys Arg 
            20                  25                  30          


Lys Val Gly Ile His Gly Val Pro Ala Ala Val Asp Leu Arg Thr Leu 
        35                  40                  45              


Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser 
    50                  55                  60                  


Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His 
65                  70                  75                  80  


Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val 
                85                  90                  95      


Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His 
            100                 105                 110         


Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu 
        115                 120                 125             


Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln 
    130                 135                 140                 


Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr 
145                 150                 155                 160 


Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro 
                165                 170                 175     


Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
            180                 185                 190         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        195                 200                 205             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
    210                 215                 220                 


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
225                 230                 235                 240 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                245                 250                 255     


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            260                 265                 270         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        275                 280                 285             


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    290                 295                 300                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
305                 310                 315                 320 


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
                325                 330                 335     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            340                 345                 350         


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
        355                 360                 365             


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    370                 375                 380                 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
385                 390                 395                 400 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                405                 410                 415     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
            420                 425                 430         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        435                 440                 445             


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
    450                 455                 460                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
465                 470                 475                 480 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
                485                 490                 495     


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            500                 505                 510         


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
        515                 520                 525             


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    530                 535                 540                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
545                 550                 555                 560 


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                565                 570                 575     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            580                 585                 590         


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
        595                 600                 605             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
    610                 615                 620                 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
625                 630                 635                 640 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                645                 650                 655     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
            660                 665                 670         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        675                 680                 685             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    690                 695                 700                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
705                 710                 715                 720 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
                725                 730                 735     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            740                 745                 750         


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
        755                 760                 765             


Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg 
    770                 775                 780                 


Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu 
785                 790                 795                 800 


Ala Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu 
                805                 810                 815     


Pro His Ala Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu 
            820                 825                 830         


Arg Thr Ser His Arg Val Ala Gly Ser Gln Leu Val Lys Ser Glu Leu 
        835                 840                 845             


Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His 
    850                 855                 860                 


Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg 
865                 870                 875                 880 


Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr 
                885                 890                 895     


Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr 
            900                 905                 910         


Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala 
        915                 920                 925             


Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln 
    930                 935                 940                 


Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn 
945                 950                 955                 960 


Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu 
                965                 970                 975     


Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg 
            980                 985                 990         


Leu Asn His Ile Thr Asn Cys Asn  Gly Ala Val Leu Ser  Val Glu Glu 
        995                 1000                 1005             


Leu Leu  Ile Gly Gly Glu Met  Ile Lys Ala Gly Thr  Leu Thr Leu 
    1010                 1015                 1020             


Glu Glu  Val Arg Arg Lys Phe  Asn Asn Gly Glu Ile  Asn Phe Arg 
    1025                 1030                 1035             


Ser 
    


<210>  28
<211>  1039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALEN 33 Right protein

<400>  28

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Gly Gly Ser Gly Pro Lys Lys Lys Arg 
            20                  25                  30          


Lys Val Gly Ile His Gly Val Pro Ala Ala Val Asp Leu Arg Thr Leu 
        35                  40                  45              


Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser 
    50                  55                  60                  


Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His 
65                  70                  75                  80  


Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val 
                85                  90                  95      


Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His 
            100                 105                 110         


Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu 
        115                 120                 125             


Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln 
    130                 135                 140                 


Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr 
145                 150                 155                 160 


Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro 
                165                 170                 175     


Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
            180                 185                 190         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        195                 200                 205             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
    210                 215                 220                 


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
225                 230                 235                 240 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                245                 250                 255     


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            260                 265                 270         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        275                 280                 285             


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    290                 295                 300                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
305                 310                 315                 320 


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
                325                 330                 335     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            340                 345                 350         


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
        355                 360                 365             


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    370                 375                 380                 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
385                 390                 395                 400 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                405                 410                 415     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
            420                 425                 430         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        435                 440                 445             


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
    450                 455                 460                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
465                 470                 475                 480 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
                485                 490                 495     


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            500                 505                 510         


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
        515                 520                 525             


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    530                 535                 540                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
545                 550                 555                 560 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                565                 570                 575     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            580                 585                 590         


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
        595                 600                 605             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
    610                 615                 620                 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
625                 630                 635                 640 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                645                 650                 655     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
            660                 665                 670         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        675                 680                 685             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
    690                 695                 700                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
705                 710                 715                 720 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
                725                 730                 735     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            740                 745                 750         


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
        755                 760                 765             


Asn Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg 
    770                 775                 780                 


Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu 
785                 790                 795                 800 


Ala Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu 
                805                 810                 815     


Pro His Ala Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu 
            820                 825                 830         


Arg Thr Ser His Arg Val Ala Gly Ser Gln Leu Val Lys Ser Glu Leu 
        835                 840                 845             


Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His 
    850                 855                 860                 


Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg 
865                 870                 875                 880 


Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr 
                885                 890                 895     


Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr 
            900                 905                 910         


Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala 
        915                 920                 925             


Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln 
    930                 935                 940                 


Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn 
945                 950                 955                 960 


Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu 
                965                 970                 975     


Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg 
            980                 985                 990         


Leu Asn His Ile Thr Asn Cys Asn  Gly Ala Val Leu Ser  Val Glu Glu 
        995                 1000                 1005             


Leu Leu  Ile Gly Gly Glu Met  Ile Lys Ala Gly Thr  Leu Thr Leu 
    1010                 1015                 1020             


Glu Glu  Val Arg Arg Lys Phe  Asn Asn Gly Glu Ile  Asn Phe Arg 
    1025                 1030                 1035             


Ser 
    


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  29
cctaggaccc cttctcgtgt                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer

<400>  30
actgagccag gagaaacggg                                                   20


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SV40 Large T-Antigen NLS

<400>  31

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nucleoplasmin NLS

<400>  32

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  33
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGL-13 NLS

<400>  33

Met Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala 
1               5                   10                  15      


Lys Lys Leu Ala Lys Glu Val Glu Asn 
            20                  25  


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-Myc proto-oncoprotein NLS

<400>  34

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TUS-protein NLS

<400>  35

Lys Leu Lys Ile Lys Arg Pro Val Lys 
1               5                   


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG tag

<400>  36

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG tag

<400>  37

Glu Tyr Lys Glu Glu Glu Glu Lys 
1               5               


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hexa-histidine

<400>  38

His His His His His His 
1               5       


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myc tag

<400>  39

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  influenza HA tag

<400>  40

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AcV5 tag

<400>  41

Ser Trp Lys Asp Ala Ser Gly Trp Ser 
1               5                   


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALFA-tag

<400>  42

Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu 
1               5                   10              


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AviTag

<400>  43

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-tag

<400>  44

Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-tag

<400>  45

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep-tag

<400>  46

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T7 tag

<400>  47

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
1               5                   10      


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ty1 tag

<400>  48

Glu Val His Thr Asn Gln Asp Pro Leu Asp 
1               5                   10  


<210>  49
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag

<400>  49

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSV-G tag

<400>  50

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xpress tag

<400>  51

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  52
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALE 28 Left DNA binding sequence with N-terminal

<400>  52

Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
1               5                   10                  15      


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
            20                  25                  30          


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
        35                  40                  45              


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
    50                  55                  60                  


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
65                  70                  75                  80  


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
                85                  90                  95      


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
            100                 105                 110         


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
        115                 120                 125             


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    530                 535                 540                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
545                 550                 555                 560 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                565                 570                 575     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
            580                 585                 590         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        595                 600                 605             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
    610                 615                 620                 


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
625                 630                 635                 640 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                645                 650                 655     


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            660                 665                 670         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        675                 680                 685             


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    690                 695                 700                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
705                 710                 715                 720 


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
                725                 730                 735     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            740                 745                 750         


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        755                 760             


<210>  53
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALE 28 Right DNA binding sequence with N-terminal

<400>  53

Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
1               5                   10                  15      


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
            20                  25                  30          


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
        35                  40                  45              


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
    50                  55                  60                  


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
65                  70                  75                  80  


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
                85                  90                  95      


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
            100                 105                 110         


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
        115                 120                 125             


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    530                 535                 540                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
545                 550                 555                 560 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                565                 570                 575     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
            580                 585                 590         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        595                 600                 605             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
    610                 615                 620                 


Asn Gly Gly 
625         


<210>  54
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALE 33 Left DNA binding sequence with N-terminal

<400>  54

Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
1               5                   10                  15      


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
            20                  25                  30          


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
        35                  40                  45              


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
    50                  55                  60                  


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
65                  70                  75                  80  


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
                85                  90                  95      


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
            100                 105                 110         


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
        115                 120                 125             


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    530                 535                 540                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
545                 550                 555                 560 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                565                 570                 575     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
            580                 585                 590         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        595                 600                 605             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
    610                 615                 620                 


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
625                 630                 635                 640 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                645                 650                 655     


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            660                 665                 670         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        675                 680                 685             


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    690                 695                 700                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
705                 710                 715                 720 


Val Ala Ile Ala Ser Asn Gly Gly Gly 
                725                 


<210>  55
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TALE 33 Right DNA binding sequence with N-terminal

<400>  55

Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
1               5                   10                  15      


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
            20                  25                  30          


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
        35                  40                  45              


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
    50                  55                  60                  


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
65                  70                  75                  80  


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
                85                  90                  95      


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
            100                 105                 110         


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
        115                 120                 125             


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    530                 535                 540                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
545                 550                 555                 560 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                565                 570                 575     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
            580                 585                 590         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        595                 600                 605             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
    610                 615                 620                 


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
625                 630                 635                 640 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                645                 650                 655     


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            660                 665                 670         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        675                 680                 685             


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    690                 695                 700                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
705                 710                 715                 720 


Val Ala Ile Ala Ser Asn Asn Gly Gly 
                725                 


