                         SEQUENCE LISTING

<110>  1E THERAPEUTICS, LTD.
       PILPEL, Noam
       OVADYA, Yossi
       RAICHLIN, Dina
       KATZ-KADOSH, Etti
       KNANY, Alaa
       GILLIS, Ella
       BOROVSKY, Noam
       BARKEY, Shirin
       COHEN, Noam
       KRIEGER, Gat
       HACOHEN, Adar
       SHAPIRO, Anastasia
       BACHELET, Ido
 
<120>  P21 MRNA TARGETING DNAZYMES

<130>  90578

<150>  US 63/130,937
<151>  2020-12-28

<160>  125   

<170>  PatentIn version 3.5

<210>  1
<211>  2378
<212>  DNA
<213>  homo sapiens

<400>  1
atgttgagct ctggcataga agaggctggt ggctattttg tccttgggct gcctgttttc       60

aggtgaggaa ggggatggta ggagacagga gacctctaaa gaccccagaa ataaaggatg      120

acaagcagag agccccgggc aggaggcaaa agtcctgtgt tccaactata gtcatttctt      180

tgctgcatga tctgagttag gtcaccagac ttctctgagc cccagtttcc ccagcagtgt      240

atacgggcta tgtggggagt attcaggaga cagacaactc actcgtcaaa tcctcccctt      300

cctggccaac aaagctgctg caaccacagg gatttcttct gttcaggcgc catgtcagaa      360

ccggctgggg atgtccgtca gaacccatgc ggcagcaagg cctgccgccg cctcttcggc      420

ccagtggaca gcgagcagct gagccgcgac tgtgatgcgc taatggcggg ctgcatccag      480

gaggcccgtg agcgatggaa cttcgacttt gtcaccgaga caccactgga gggtgacttc      540

gcctgggagc gtgtgcgggg ccttggcctg cccaagctct accttcccac ggggccccgg      600

cgaggccggg atgagttggg aggaggcagg cggcctggca cctcacctgc tctgctgcag      660

gggacagcag aggaagacca tgtggacctg tcactgtctt gtacccttgt gcctcgctca      720

ggggagcagg ctgaagggtc cccaggtgga cctggagact ctcagggtcg aaaacggcgg      780

cagaccagca tgacagattt ctaccactcc aaacgccggc tgatcttctc caagaggaag      840

ccctaatccg cccacaggaa gcctgcagtc ctggaagcgc gagggcctca aaggcccgct      900

ctacatcttc tgccttagtc tcagtttgtg tgtcttaatt attatttgtg ttttaattta      960

aacacctcct catgtacata ccctggccgc cccctgcccc ccagcctctg gcattagaat     1020

tatttaaaca aaaactaggc ggttgaatga gaggttccta agagtgctgg gcatttttat     1080

tttatgaaat actatttaaa gcctcctcat cccgtgttct ccttttcctc tctcccggag     1140

gttgggtggg ccggcttcat gccagctact tcctcctccc cacttgtccg ctgggtggta     1200

ccctctggag gggtgtggct ccttcccatc gctgtcacag gcggttatga aattcacccc     1260

ctttcctgga cactcagacc tgaattcttt ttcatttgag aagtaaacag atggcacttt     1320

gaaggggcct caccgagtgg gggcatcatc aaaaactttg gagtcccctc acctcctcta     1380

aggttgggca gggtgaccct gaagtgagca cagcctaggg ctgagctggg gacctggtac     1440

cctcctggct cttgataccc ccctctgtct tgtgaaggca gggggaaggt ggggtcctgg     1500

agcagaccac cccgcctgcc ctcatggccc ctctgacctg cactggggag cccgtctcag     1560

tgttgagcct tttccctctt tggctcccct gtaccttttg aggagcccca gctacccttt     1620

ttctccagct gggctctgca attcccctct gctgctgtcc ctcccccttg tcctttccct     1680

tcagtaccct ctcagctcca ggtggctctg aggtgcctgt cccaccccca cccccagctc     1740

aatggactgg aaggggaagg gacacacaag aagaagggca ccctagttct acctcaggca     1800

gctcaagcag cgaccgcccc ctcctctagc tgtgggggtg agggtcccat gtggtggcac     1860

aggccccctt gagtggggtt atctctgtgt taggggtata tgatggggga gtagatcttt     1920

ctaggaggga gacactggcc cctcaaatcg tccagcgacc ttcctcatcc accccatccc     1980

tccccagttc attgcacttt gattagcagc ggaacaagga gtcagacatt ttaagatggt     2040

ggcagtagag gctatggaca gggcatgcca cgtgggctca tatggggctg ggagtagttg     2100

tctttcctgg cactaacgtt gagcccctgg aggcactgaa gtgcttagtg tacttggagt     2160

attggggtct gaccccaaac accttccagc tcctgtaaca tactggcctg gactgttttc     2220

tctcggctcc ccatgtgtcc tggttcccgt ttctccacct agactgtaaa cctctcgagg     2280

gcagggacca caccctgtac tgttctgtgt ctttcacagc tcctcccaca atgctgaata     2340

tacagcaggt gctcaataaa tgattcttag tgacttta                             2378


<210>  2
<211>  198
<212>  PRT
<213>  homo sapiens

<400>  2

Met Trp Gly Val Phe Arg Arg Gln Thr Thr His Ser Ser Asn Pro Pro 
1               5                   10                  15      


Leu Pro Gly Gln Gln Ser Cys Cys Asn His Arg Asp Phe Phe Cys Ser 
            20                  25                  30          


Gly Ala Met Ser Glu Pro Ala Gly Asp Val Arg Gln Asn Pro Cys Gly 
        35                  40                  45              


Ser Lys Ala Cys Arg Arg Leu Phe Gly Pro Val Asp Ser Glu Gln Leu 
    50                  55                  60                  


Ser Arg Asp Cys Asp Ala Leu Met Ala Gly Cys Ile Gln Glu Ala Arg 
65                  70                  75                  80  


Glu Arg Trp Asn Phe Asp Phe Val Thr Glu Thr Pro Leu Glu Gly Asp 
                85                  90                  95      


Phe Ala Trp Glu Arg Val Arg Gly Leu Gly Leu Pro Lys Leu Tyr Leu 
            100                 105                 110         


Pro Thr Gly Pro Arg Arg Gly Arg Asp Glu Leu Gly Gly Gly Arg Arg 
        115                 120                 125             


Pro Gly Thr Ser Pro Ala Leu Leu Gln Gly Thr Ala Glu Glu Asp His 
    130                 135                 140                 


Val Asp Leu Ser Leu Ser Cys Thr Leu Val Pro Arg Ser Gly Glu Gln 
145                 150                 155                 160 


Ala Glu Gly Ser Pro Gly Gly Pro Gly Asp Ser Gln Gly Arg Lys Arg 
                165                 170                 175     


Arg Gln Thr Ser Met Thr Asp Phe Tyr His Ser Lys Arg Arg Leu Ile 
            180                 185                 190         


Phe Ser Lys Arg Lys Pro 
        195             


<210>  3
<211>  1913
<212>  DNA
<213>  Mus musculus

<400>  3
tgcagcagcc gagaggtgtg agccgccgcg gtgtcagagt ctaggggaat tggagtcagg       60

cgcagatcca cagcgatatc cagacattca gagccacagg caccatgtcc aatcctggtg      120

atgtccgacc tgttccgcac aggagcaaag tgtgccgttg tctcttcggt cccgtggaca      180

gtgagcagtt gcgccgtgat tgcgatgcgc tcatggcggg ctgtctccag gaggcccgag      240

aacggtggaa ctttgacttc gtcacggaga cgccgctgga gggcaacttc gtctgggagc      300

gcgttcggag cctagggctg cccaaggtct acctgagccc tgggtcccgc agccgtgacg      360

acctgggagg ggacaagagg cccagtactt cctctgccct gctgcagggg ccagctccgg      420

aggaccacgt ggccttgtcg ctgtcttgca ctctggtgtc tgagcggcct gaagattccc      480

cgggtgggcc cggaacatct cagggccgaa aacggaggca gaccagcctg acagatttct      540

atcactccaa gcgcagattg gtcttctgca agagaaaacc ctgaagtgcc cacgggagcc      600

ccgccctctt ctgctgtggg tcaggaggcc tcttccccat cttcggcctt agccctcact      660

ctgtgtgtct taattattat ttgtgtttta atttaaacgt ctcctgtata tacgctgcct      720

gccctctccc agtctccaaa cttaaagtta tttaaaaaaa gaacaaaaca aaacaaaaaa      780

aaccaaaaca aaacaaacct aaattagtag gacggtaggg cccttagtgt gggggatttc      840

tattatgtag attattatta tttaagcccc tcccaaccca agctctgtgt ttcctatacc      900

ggaggaacag tcctactgat atcaacccat ctgcatccgt ttcacccaac ccccctcccc      960

ccattccctg cctggttcct tgccacttct tacctggggg tgatcctcag acctgaatag     1020

cactttggaa aaatgagtag gactttgggg tctccttgtc acctctaagg ccagctagga     1080

tgacagtgaa gcagtcacag cctagaacag ggatggcagt taggactcaa ccgtaatatc     1140

ccgactcttg acattgctca gacctgtgaa gacaggaatg gtccccactc tggatcccct     1200

ttgccactcc tggggagccc acctctcctg tgggtctctg ccagctgccc ctctattttg     1260

gagggttaat ctggtgatct gctgctcttt tcccccaccc catacttccc cttctgcagg     1320

tcggcaggag gcatatctag gcacttgccc cacagctcag tggactggaa gggaatgtat     1380

atgcagggta cactaagtgg gattccctgg tcttacctta ggcagctcca gtggcaaccc     1440

cctgcattgt gggtctaggg tgggtccttg gtggtgagac aggcctccca gagcattcta     1500

tggtgtgtgg tggtgggggt gggcttatct gggatgggga ccccagttgg ggttctcagt     1560

gacttctccc atttcttagt agcagttgta caaggagcca ggccaagatg gtgtcttggg     1620

ggctaaggga gctcacagga cactgagcaa tggctgatcc tttctcagtg ttgaataccg     1680

tgggtgtcaa agcacttagt gggtctgact ccagccccaa acatccctgt ttctgtaaca     1740

tcctggtctg gactgtctac ccttagcccg caccccaaga acatgtattg tggctccctc     1800

cctgtctcca ctcagattgt aagcgtctca cgagaaggga cagcaccctg cattgtcccg     1860

agtcctcaca cccgacccca aagctggtgc tcaataaata cttctcgatg att            1913


<210>  4
<211>  159
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ser Asn Pro Gly Asp Val Arg Pro Val Pro His Arg Ser Lys Val 
1               5                   10                  15      


Cys Arg Cys Leu Phe Gly Pro Val Asp Ser Glu Gln Leu Arg Arg Asp 
            20                  25                  30          


Cys Asp Ala Leu Met Ala Gly Cys Leu Gln Glu Ala Arg Glu Arg Trp 
        35                  40                  45              


Asn Phe Asp Phe Val Thr Glu Thr Pro Leu Glu Gly Asn Phe Val Trp 
    50                  55                  60                  


Glu Arg Val Arg Ser Leu Gly Leu Pro Lys Val Tyr Leu Ser Pro Gly 
65                  70                  75                  80  


Ser Arg Ser Arg Asp Asp Leu Gly Gly Asp Lys Arg Pro Ser Thr Ser 
                85                  90                  95      


Ser Ala Leu Leu Gln Gly Pro Ala Pro Glu Asp His Val Ala Leu Ser 
            100                 105                 110         


Leu Ser Cys Thr Leu Val Ser Glu Arg Pro Glu Asp Ser Pro Gly Gly 
        115                 120                 125             


Pro Gly Thr Ser Gln Gly Arg Lys Arg Arg Gln Thr Ser Leu Thr Asp 
    130                 135                 140                 


Phe Tyr His Ser Lys Arg Arg Leu Val Phe Cys Lys Arg Lys Pro 
145                 150                 155                 


<210>  5
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  control DNZ_Scramble Arm

<400>  5
atcttccttg gctagctaca acgacgcctc tcc                                    33


<210>  6
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  6
cctcttctag gctagctaca acgagccaga gct                                    33


<210>  7
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  7
ctcctaccag gctagctaca acgacccctt cct                                    33


<210>  8
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  8
tgtctcctag gctagctaca acgacatccc ctt                                    33


<210>  9
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  9
tctggggttc cgagccggac gattagaggt c                                      31


<210>  10
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  10
catcctttag gctagctaca acgattctgg ggt                                    33


<210>  11
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  11
gcaaagaaag gctagctaca acgagactat agt                                    33


<210>  12
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  12
cagatcatgg gctagctaca acgaagcaaa gaa                                    33


<210>  13
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  13
tggggaaatc cgagccggac gaggggctca g                                      31


<210>  14
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  14
ctggggaaag gctagctaca acgatggggc tca                                    33


<210>  15
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  15
cgtatacatc cgagccggac gagctgggga a                                      31


<210>  16
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  16
ccgtatacag gctagctaca acgatgctgg gga                                    33


<210>  17
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  17
tactccccag gctagctaca acgaatagcc cgt                                    33


<210>  18
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  18
gtctgtcttc cgagccggac gatgaatact c                                      31


<210>  19
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  19
aggggaggag gctagctaca acgattgacg agt                                    33


<210>  20
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  20
tttgttggtc cgagccggac gaaggaaggg g                                      31


<210>  21
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  21
tggttgcagg gctagctaca acgaagcttt gtt                                    33


<210>  22
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  22
gttctgacag gctagctaca acgaggcgcc tga                                    33


<210>  23
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  23
cggttctgag gctagctaca acgaatggcg cct                                    33


<210>  24
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  24
tgacggacag gctagctaca acgaccccag ccg                                    33


<210>  25
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  25
gggttctgag gctagctaca acgaggacat ccc                                    33


<210>  26
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  26
gctgccgcag gctagctaca acgagggttc tga                                    33


<210>  27
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  27
aggccttgtc cgagccggac gagccgcatg g                                      31


<210>  28
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  28
agtcgcggtc cgagccggac gacagctgct c                                      31


<210>  29
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  29
gaagttccag gctagctaca acgacgctca cgg                                    33


<210>  30
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  30
gcucccaggg gctagctaca acgagaaguc acc                                    33


<210>  31
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  31
atcccggctc cgagccggac gacgccgggg c                                      31


<210>  32
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  32
agggcttctc cgagccggac gacttggaga a                                      31


<210>  33
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  33
gtgggcggag gctagctaca acgatagggc ttc                                    33


<210>  34
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  34
gcaggctttc cgagccggac gatgtgggcg g                                      31


<210>  35
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  35
gggtatgtag gctagctaca acgaatgagg agg                                    33


<210>  36
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  36
gggggcggtc cgagccggac gaagggtatg t                                      31


<210>  37
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  37
gccagaggtc cgagccggac gaggggggca g                                      31


<210>  38
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  38
taattctaag gctagctaca acgagccaga ggc                                    33


<210>  39
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  39
taaatagtag gctagctaca acgattcata aaa                                    33


<210>  40
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  40
aggagaacag gctagctaca acgagggaug agg                                    33


<210>  41
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  41
aaaggagaag gctagctaca acgaacggga uga                                    33


<210>  42
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  42
gggggtgaag gctagctaca acgattcata acc                                    33


<210>  43
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  43
gctcagcctc cgagccggac gaaggctgtg c                                      31


<210>  44
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  44
agctcagctc cgagccggac gataggctgt g                                      31


<210>  45
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  45
aggggggtag gctagctaca acgacaagag cca                                    33


<210>  46
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  46
ttcacaagag gctagctaca acgaagaggg ggg                                    33


<210>  47
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  47
ggggtggttc cgagccggac gagctccagg a                                      31


<210>  48
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  48
gaggggccag gctagctaca acgagagggc agg                                    33


<210>  49
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  49
caggggagtc cgagccggac gaaaagaggg a                                      31


<210>  50
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  50
caaaaggtag gctagctaca acgaagggga gcc                                    33


<210>  51
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  51
ctggggcttc cgagccggac gatcaaaagg t                                      31


<210>  52
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  52
aagggtagtc cgagccggac gaggggctcc t                                      31


<210>  53
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  53
agaggggaag gctagctaca acgatgcaga gcc                                    33


<210>  54
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  54
gggaaaggag gctagctaca acgaaagggg gag                                    33


<210>  55
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  55
agagggtatc cgagccggac gagaagggaa a                                      31


<210>  56
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  56
gagagggtag gctagctaca acgatgaagg gaa                                    33


<210>  57
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  57
ggggtgggag gctagctaca acgaaggcac ctc                                    33


<210>  58
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  58
ccattgagtc cgagccggac gagggggtgg g                                      31


<210>  59
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  59
tccagtccag gctagctaca acgatgagct ggg                                    33


<210>  60
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  60
gaggtagaag gctagctaca acgatagggt gcc                                    33


<210>  61
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  61
ugccugaggg gctagctaca acgaagaacu agg                                    33


<210>  62
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  62
ugcuugagtc cgagccggac gagccugagg u                                      31


<210>  63
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  63
ggaccctcag gctagctaca acgaccccac agc                                    33


<210>  64
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  64
gtgccaccag gctagctaca acgaatggga ccc                                    33


<210>  65
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  65
cctgtgccag gctagctaca acgacacatg gga                                    33


<210>  66
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  66
taaccccatc cgagccggac gacaaggggg c                                      31


<210>  67
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  67
ataaccccag gctagctaca acgatcaagg ggg                                    33


<210>  68
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  68
tttgaggggg gctagctaca acgacagtgt ctc                                    33


<210>  69
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  69
gctggacgag gctagctaca acgattgagg ggc                                    33


<210>  70
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  70
tggggtggag gctagctaca acgagaggaa ggt                                    33


<210>  71
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  71
ggggagggag gctagctaca acgaggggtg gat                                    33


<210>  72
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  72
gcaatgaatc cgagccggac gaggggaggg a                                      31


<210>  73
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  73
tgcaatgaag gctagctaca acgatgggga ggg                                    33


<210>  74
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  74
aaagtgcaag gctagctaca acgagaactg ggg                                    33


<210>  75
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  75
aggccagtag gctagctaca acgagttaca gga                                    33


<210>  76
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  76
gagagaaaag gctagctaca acgaagtcca ggc                                    33


<210>  77
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  77
accaggacag gctagctaca acgaatgggg agc                                    33


<210>  78
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNAzymes targeting human p21 mRNA

<400>  78
agaggtttag gctagctaca acgaagtcta ggt                                    33


<210>  79
<211>  80
<212>  DNA
<213>  Artificial sequence

<220>
<223>  human T7 CDKN1A FORWARD primer

<400>  79
taatacgact cactatagat gttgagctct ggcatagaag aggctggtgg ctattttgtc       60

cttgggctgc ctgttttcag                                                   80


<210>  80
<211>  80
<212>  DNA
<213>  Artificial sequence

<220>
<223>  human T7 CDKN1A reverse primer

<400>  80
taaagtcact aagaatcatt tattgagcac ctgctgtata ttcagcattg tgggaggagc       60

tgtgaaagac acagaacagt                                                   80


<210>  81
<211>  67
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mouse cdkn1a_REVERSE primer

<400>  81
aatcatcgag aagtatttat tgagcaccag ctttggggtc gggtgtgagg actcgggaca       60

atgcagg                                                                 67


<210>  82
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mouse cdkn1a_FORWARD primer

<400>  82
taatacgact cactatagtg cagcagccga gaggtgtgag ccgcc                       45


<210>  83
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mouse DNAzyme 557

<400>  83
gaagaccaag gctagctaca acgactgcgc ttg                                    33


<210>  84
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mouse DNAzyme 291

<400>  84
gctcccagag gctagctaca acgagaagtt gcc                                    33


<210>  85
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mouse DNAzyme 639

<400>  85
ggccgaagag gctagctaca acgaggggaa gag                                    33


<210>  86
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  control DNZ_Scramble

<400>  86
aggagaacaa cagtaactgg cgacgggatg agg                                    33


<210>  87
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  control DNZ_Scramble for mouse

<400>  87
gaagaggagg gctagctaca acgacgacgg agg                                    33


<210>  88
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  catalytic domain of 10-23 DNAzymes

<400>  88
ggctagctac aacga                                                        15


<210>  89
<211>  14
<212>  DNA
<213>  Artificial sequence

<220>
<223>  catalytic domain of 8-17 DNAzymes

<400>  89
tccgagccgg acga                                                         14


<210>  90
<211>  11
<212>  DNA
<213>  Artificial sequence

<220>
<223>  16.2-11 catalytic core

<400>  90
gtgaccccuu g                                                            11


<210>  91
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  9-86 catalytic core

<400>  91
ucaugcagcg cguaguguc                                                    19


<210>  92
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  12-91 catalytic core

<400>  92
ugaugcagcg cauguguc                                                     18


<210>  93
<211>  13
<212>  DNA
<213>  Artificial sequence

<220>
<223>  12-91 catalytic core

<400>  93
aagcaguuaa gac                                                          13


<210>  94
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bipartite I or Bipartite II catalytic core

<400>  94
aaggaggtag gggttccgct cc                                                22


<210>  95
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  95
tggtatcgtg gaaggactca                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  96
ccagtagagg cagggatgat                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  97
tcaaaggccc gctctacatc                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  98
tgcccagcac tcttaggaac                                                   20


<210>  99
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  99
tcaagctcat ttcctggtat gaca                                              24


<210>  100
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  100
tagggcctct cttgctcagt                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  101
gtgtgccgtt gtctcttcgg                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  102
ctcaggtaga ccttgggcag                                                   20


<210>  103
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  103
catctggagc agcatggagt c                                                 21


<210>  104
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  104
gttgcccatc atcatcacct gaat                                              24


<210>  105
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  105
tccttagcca ctccttctgt                                                   20


<210>  106
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  106
agccagagtc cttcagaga                                                    19


<210>  107
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  107
tcccaaagaa gctgtagttt ttgtc                                             25


<210>  108
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  108
cccattcctt cttggggtca                                                   20


<210>  109
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  109
ccaacaagca tgtctggtta ggag                                              24


<210>  110
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  110
gcaatgctgt tcttgcagtg gta                                               23


<210>  111
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  111
agcaggtcag caaagaact                                                    19


<210>  112
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  112
cctcatggac tgattatgga ca                                                22


<210>  113
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  113
ttccaggctt tgggcatca                                                    19


<210>  114
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  114
atgttcagca tgttcagcag tgtg                                              24


<210>  115
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  115
gctcctgcct cacatcatac                                                   20


<210>  116
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  116
ggcttctctg catctgtgaa                                                   20


<210>  117
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  117
gagacacacc agagcagata cc                                                22


<210>  118
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  118
ggggaaccca tgaatttagc c                                                 21


<210>  119
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  119
tatggggctg ggagtagttg t                                                 21


<210>  120
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  120
gggagccgag agaaaacagt c                                                 21


<210>  121
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  121
gacagcagag gaagaccatg tggac                                             25


<210>  122
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  122
gagtggtaga aatctgtcat gctg                                              24


<210>  123
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  123
ttggctcccc tgtacctttt g                                                 21


<210>  124
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  124
tggagctgag agggtactga                                                   20


<210>  125
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  control DNZ_Scramble

<400>  125
gtgtggcgcc cgagccggac gagagtggag g                                      31


