                         SEQUENCE LISTING

<110>  Tiamat Sciences
 
<120>  PLANT-BASED SYNTHESIS PRODUCTS

<130>  P10800WO01

<140>  PCT/EP2022/050091
<141>  2022-01-04

<150>  US 63/133,591
<151>  2021-01-04

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210>  2
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  3
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210>  4
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly 
1               5                   10                  15      


Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg 
            20                  25                  30          


Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser 
        35                  40                  45              


Arg Pro Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu 
    50                  55                  60                  


Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His 
65                  70                  75                  80  


Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu 
                85                  90                  95      


Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp 
            100                 105                 110         


Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser 
        115                 120                 125             


Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly 
    130                 135                 140                 


Arg Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu 
145                 150                 155                 160 


Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr 
                165                 170                 175     


Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser 
            180                 185                 190         


Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala 
        195                 200                 205             


Lys Ser 
    210 


<210>  5
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  6
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg 
1               5                   10                  15      


Gly Arg Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg 
            20                  25                  30          


Gly Ser Arg Pro Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr 
        35                  40                  45              


Thr Leu Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro 
    50                  55                  60                  


Gly His Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe 
65                  70                  75                  80  


Phe Leu Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys 
                85                  90                  95      


Ser Asp Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val 
            100                 105                 110         


Val Ser Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu 
        115                 120                 125             


Asp Gly Arg Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe 
    130                 135                 140                 


Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys 
145                 150                 155                 160 


Tyr Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu 
                165                 170                 175     


Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met 
            180                 185                 190         


Ser Ala Lys Ser 
        195     


<210>  7
<211>  156
<212>  PRT
<213>  Lycopersicon esculentum

<400>  7

Ala His Leu Glu Tyr Val Glu Asn Leu Asn Val Lys Glu Gln Leu Val 
1               5                   10                  15      


Ala Gly Thr Leu Tyr Tyr Ile Thr Leu Val Ala Thr Asp Ala Gly Lys 
            20                  25                  30          


Lys Lys Ile Tyr Glu Thr Lys Ile Trp Val Lys Glu Trp Glu Asp Phe 
        35                  40                  45              


Lys Lys Val Val Glu Phe Lys Leu Val Gly Asp Asp Ser Pro Asn Pro 
    50                  55                  60                  


Gly Gly Ile Thr Asn Val Pro Phe Pro Asn Leu Pro Gln Phe Lys Asp 
65                  70                  75                  80  


Leu Ala Arg Phe Ala Val Gln Asp Tyr Asn Lys Lys Glu Asn Ala His 
                85                  90                  95      


Leu Glu Phe Val Glu Asn Leu Asn Val Lys Glu Gln Val Val Ala Gly 
            100                 105                 110         


Ile Ile Tyr Tyr Ile Thr Leu Val Ala Thr Asp Ala Gly Lys Lys Lys 
        115                 120                 125             


Ile Tyr Glu Thr Lys Ile Leu Val Lys Gly Trp Glu Asn Phe Lys Glu 
    130                 135                 140                 


Val Gln Glu Phe Lys Leu Val Gly Asp Ala Thr Lys 
145                 150                 155     


<210>  8
<211>  158
<212>  PRT
<213>  Gallus gallus

<400>  8

Met Ala Ala Gly Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro 
1               5                   10                  15      


Asp Asp Gly Gly Gly Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro 
            20                  25                  30          


Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile Asn Pro 
        35                  40                  45              


Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys 
    50                  55                  60                  


Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val 
65                  70                  75                  80  


Ser Ala Asn Arg Phe Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala 
                85                  90                  95      


Leu Lys Cys Ala Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser 
            100                 105                 110         


Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Ser Asp Trp Tyr Val 
        115                 120                 125             


Ala Leu Lys Arg Thr Gly Gln Tyr Lys Pro Gly Pro Lys Thr Gly Pro 
    130                 135                 140                 


Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155             


<210>  9
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  9

Met His His His His His His His His His His His His Asp Asp Asp 
1               5                   10                  15      


Asp Lys Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln 
            20                  25                  30          


Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His 
        35                  40                  45              


Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe 
    50                  55                  60                  


Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu 
65                  70                  75                  80  


Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro 
                85                  90                  95      


Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys 
            100                 105                 110         


Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu 
        115                 120                 125             


Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln 
    130                 135                 140                 


Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp 
145                 150                 155                 160 


Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
                165                 170     


<210>  10
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  11
<211>  114
<212>  PRT
<213>  Gallus gallus

<400>  11

Asp Leu Asp Thr Asp Tyr Cys Phe Gly Pro Gly Thr Asp Glu Lys Asn 
1               5                   10                  15      


Cys Cys Val Arg Pro Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gln Trp 
            20                  25                  30          


Lys Trp Ile His Glu Pro Lys Gly Tyr Met Ala Asn Phe Cys Met Gly 
        35                  40                  45              


Pro Cys Pro Tyr Ile Trp Ser Ala Asp Thr Gln Tyr Thr Lys Val Leu 
    50                  55                  60                  


Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys 
65                  70                  75                  80  


Val Pro Gln Thr Leu Asp Pro Leu Pro Ile Ile Tyr Tyr Val Gly Arg 
                85                  90                  95      


Asn Val Arg Val Glu Gln Leu Ser Asn Met Val Val Arg Ala Cys Lys 
            100                 105                 110         


Cys Ser 
        


<210>  12
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  13
<211>  70
<212>  PRT
<213>  Gallus gallus

<400>  13

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Leu His His Lys Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Gln Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Ile 
    50                  55                  60                  


Lys Pro Pro Lys Ser Ala 
65                  70  


<210>  14
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  15
<211>  179
<212>  PRT
<213>  Bos taurus

<400>  15

Met Gly Ile Thr Ala Gly Lys Ser Val Leu Val Leu Leu Ala Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Tyr Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ser Ser Arg Ile Asn Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Ala 
                85                  90                  95      


Ser Thr Thr Val Leu Pro Asp Asp Val Thr Ala Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Ile Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Phe Leu Arg Ala Arg Arg Gly Arg Thr Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Leu Arg Glu Ala Lys Ser His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala Thr His Gly Gly Ala Ser Ser Lys Ala 
                165                 170                 175     


Ser Ser Asp 
            


<210>  16
<211>  181
<212>  PRT
<213>  Sus scrofa

<400>  16

Met Gly Ile Pro Met Arg Lys Pro Leu Leu Val Leu Leu Val Phe Leu 
1               5                   10                  15      


Ala Leu Ala Ser Cys Cys Tyr Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Asn Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Arg Tyr Asp Thr Trp Lys Gln Ser Ala Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly Arg Thr Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Val Arg Glu Ala Lys Arg His Arg Pro Leu Thr Ala 
145                 150                 155                 160 


Arg Pro Thr Arg Asp Pro Ala Ala His Gly Gly Ala Ser Pro Glu Ala 
                165                 170                 175     


Ser Gly His Arg Lys 
            180     


<210>  17
<211>  187
<212>  PRT
<213>  Gallus gallus

<400>  17

Met Cys Ala Ala Arg Gln Ile Leu Leu Leu Leu Leu Ala Phe Leu Ala 
1               5                   10                  15      


Tyr Ala Leu Asp Ser Ala Ala Ala Tyr Gly Thr Ala Glu Thr Leu Cys 
            20                  25                  30          


Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly 
        35                  40                  45              


Phe Tyr Phe Ser Arg Pro Val Gly Arg Asn Asn Arg Arg Ile Asn Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Lys Ser Val Lys Ser Glu Arg Asp Leu Ser Ala 
                85                  90                  95      


Thr Ser Leu Ala Gly Leu Pro Ala Leu Asn Lys Glu Ser Phe Gln Lys 
            100                 105                 110         


Pro Ser His Ala Lys Tyr Ser Lys Tyr Asn Val Trp Gln Lys Lys Ser 
        115                 120                 125             


Ser Gln Arg Leu Gln Arg Glu Val Pro Gly Ile Leu Arg Ala Arg Arg 
    130                 135                 140                 


Tyr Arg Trp Gln Ala Glu Gly Leu Gln Ala Ala Glu Glu Ala Arg Ala 
145                 150                 155                 160 


Met His Arg Pro Leu Ile Ser Leu Pro Ser Gln Arg Pro Pro Ala Pro 
                165                 170                 175     


Arg Ala Ser Pro Glu Ala Thr Gly Pro Gln Glu 
            180                 185         


<210>  18
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  19
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210>  20
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys 
            340                 345                 350         


Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser 
        355                 360                 365             


Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys 
    370                 375                 380                 


Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu 
385                 390                 395                 400 


Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
                405                 410         


<210>  21
<211>  574
<212>  DNA
<213>  Gallus gallus

<400>  21
gaggctggac ggccgcggca gggggcgagc ccgcccggcg ctggcggcgg cggccggcgg       60

gggcccgggg cggcggggag ccgccggggc ccggcgcatg gcggcggggg cggcggggag      120

catcaccacg ctgccggcgc tgcccgacga cgggggcggc ggcgcttttc cccccgggca      180

cttcaaggac cccaagcggc tctactgcaa gaacggcggc ttcttcctgc gcatcaaccc      240

cgacggcagg gtggacggcg tccgcgagaa gagcgatccg cacatcaaac tgcagcttca      300

agcagaagaa agaggagtag tatcaatcaa aggcgtaagt gcaaaccgct ttctggctat      360

gaaggaggat ggcagattgc tggcactgaa atgtgcaaca gaggaatgtt tctttttcga      420

gcgcttggaa tctaataact ataacactta ccggtcacgg aagtactctg attggtatgt      480

ggcactgaaa aggactggac agtacaagcc cggaccaaaa actggacctg gacagaaagc      540

tatccttttt cttccaatgt ctgctaaaag ctga                                  574


<210>  22
<211>  474
<212>  DNA
<213>  Lycopersicon esculentum

<400>  22
atggcgcatc tggaatatgt ggaaaacctg aacgtgaaag aacagctggt ggcgggcacc       60

ctgtattata ttaccctggt ggcgaccgat gcgggcaaaa aaaaaattta tgaaaccaaa      120

atttgggtga aagaatggga agattttaaa aaagtggtgg aatttaaact ggtgggcgat      180

gatagcccga acccgggcgg cattaccaac gtgccgtttc cgaacctgcc gcagtttaaa      240

gatctggcgc gctttgcggt gcaggattat aacaaaaaag aaaacgcgca tctggaattt      300

gtggaaaacc tgaacgtgaa agaacaggtg gtggcgggca ttatttatta tattaccctg      360

gtggcgaccg atgcgggcaa aaaaaaaatt tatgaaacca aaattctggt gaaaggctgg      420

gaaaacttta aagaagtgca ggaatttaaa ctggtgggcg atgcgaccaa atag            474


<210>  23
<211>  867
<212>  DNA
<213>  Homo sapiens

<400>  23
ctggtgggtg tggggggtgg agatgtagaa gatgtgacgc cgcggcccgg cgggtgccag       60

attagcggac gcggtgcccg cggttgcaac gggatcccgg gcgctgcagc ttgggaggcg      120

gctctcccca ggcggcgtcc gcggagacac ccatccgtga accccaggtc ccgggccgcc      180

ggctcgccgc gcaccagggg ccggcggaca gaagagcggc cgagcggctc gaggctgggg      240

gaccgcgggc gcggccgcgc gctgccgggc gggaggctgg ggggccgggg ccggggccgt      300

gccccggagc gggtcggagg ccggggccgg ggccggggga cggcggctcc ccgcgcggct      360

ccagcggctc ggggatcccg gccgggcccc gcagggacca tggcagccgg gagcatcacc      420

acgctgcccg ccttgcccga ggatggcggc agcggcgcct tcccgcccgg ccacttcaag      480

gaccccaagc ggctgtactg caaaaacggg ggcttcttcc tgcgcatcca ccccgacggc      540

cgagttgacg gggtccggga gaagagcgac cctcacatca agctacaact tcaagcagaa      600

gagagaggag ttgtgtctat caaaggagtg tgtgctaacc gttacctggc tatgaaggaa      660

gatggaagat tactggcttc taaatgtgtt acggatgagt gtttcttttt tgaacgattg      720

gaatctaata actacaatac ttaccggtca aggaaataca ccagttggta tgtggcactg      780

aaacgaactg ggcagtataa acttggatcc aaaacaggac ctgggcagaa agctatactt      840

tttcttccaa tgtctgctaa gagctga                                          867


<210>  24
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  24
cgcgtggatg gcgtgcgcga aaaaagcgat ccgcatatta aactgcagct gcaggcggaa       60

gaacgcggcg tggtgagcat taaaggcgtg tgcgcgaacc gctatctggc gatgaaagaa      120

gatggccgcc tgctggcgag caaatgcgtg accgatgaat gctttttttt tgaacgcctg      180

gaaagcaaca actataacac ctatcgcagc cgcaaatata ccagctggta tgtggcgctg      240

aaacgcaccg gccagtataa actgggcagc aaaaccggcc cgggccagaa agcgattctg      300

tttctgccga tgagcgcgaa aagc                                             324


<210>  25
<211>  867
<212>  DNA
<213>  Homo sapiens

<400>  25
ctggtgggtg tggggggtgg agatgtagaa gatgtgacgc cgcggcccgg cgggtgccag       60

attagcggac gcggtgcccg cggttgcaac gggatcccgg gcgctgcagc ttgggaggcg      120

gctctcccca ggcggcgtcc gcggagacac ccatccgtga accccaggtc ccgggccgcc      180

ggctcgccgc gcaccagggg ccggcggaca gaagagcggc cgagcggctc gaggctgggg      240

gaccgcgggc gcggccgcgc gctgccgggc gggaggctgg ggggccgggg ccggggccgt      300

gccccggagc gggtcggagg ccggggccgg ggccggggga cggcggctcc ccgcgcggct      360

ccagcggctc ggggatcccg gccgggcccc gcagggacca tggcagccgg gagcatcacc      420

acgctgcccg ccttgcccga ggatggcggc agcggcgcct tcccgcccgg ccacttcaag      480

gaccccaagc ggctgtactg caaaaacggg ggcttcttcc tgcgcatcca ccccgacggc      540

cgagttgacg gggtccggga gaagagcgac cctcacatca agctacaact tcaagcagaa      600

gagagaggag ttgtgtctat caaaggagtg tgtgctaacc gttacctggc tatgaaggaa      660

gatggaagat tactggcttc taaatgtgtt acggatgagt gtttcttttt tgaacgattg      720

gaatctaata actacaatac ttaccggtca aggaaataca ccagttggta tgtggcactg      780

aaacgaactg ggcagtataa acttggatcc aaaacaggac ctgggcagaa agctatactt      840

tttcttccaa tgtctgctaa gagctga                                          867


<210>  26
<211>  468
<212>  DNA
<213>  Homo sapiens

<400>  26
atggcagccg ggagcatcac cacgctgccc gccttgcccg aggatggcgg cagcggcgcc       60

ttcccgcccg gccacttcaa ggaccccaag cggctgtact gcaaaaacgg gggcttcttc      120

ctgcgcatcc accccgacgg ccgagttgac ggggtccggg agaagagcga ccctcacatc      180

aagctacaac ttcaagcaga agagagagga gttgtgtcta tcaaaggagt gtgtgctaac      240

cgttacctgg ctatgaagga agatggaaga ttactggctt ctaaatgtgt tacggatgag      300

tgtttctttt ttgaacgatt ggaatctaat aactacaata cttaccggtc aaggaaatac      360

accagttggt atgtggcact gaaacgaact gggcagtata aacttggatc caaaacagga      420

cctgggcaga aagctatact ttttcttcca atgtctgcta agagctga                   468


<210>  27
<211>  528
<212>  DNA
<213>  Homo sapiens

<400>  27
ctcgagatgc atcatcatca tcatcatcat catcatcatc atcatgatga tgatgataaa       60

gcacctgtac gatcactgaa ctgcacgctc cgggactcac agcaaaaaag cttggtgatg      120

tctggtccat atgaactgaa agctctccac ctccagggac aggatatgga gcaacaagtg      180

gtgttctcca tgtcctttgt acaaggagaa gaaagtaatg acaaaatacc tgtggccttg      240

ggcctcaagg aaaagaatct gtacctgtcc tgcgtgttga aagatgataa gcccactcta      300

cagctggaga gtgtagatcc caaaaattac ccaaagaaga agatggaaaa gcgatttgtc      360

ttcaacaaga tagaaatcaa taacaagctg gaatttgagt ctgcccagtt ccccaactgg      420

tacatcagca cctctcaagc agaaaacatg cccgtcttcc tgggagggac caaaggcggc      480

caggatataa ctgacttcac catgcaattt gtgtcttcct aaacgcgt                   528


<210>  28
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  28
cgcgtggatg gcgtgcgcga aaaaagcgat ccgcatatta aactgcagct gcaggcggaa       60

gaacgcggcg tggtgagcat taaaggcgtg tgcgcgaacc gctatctggc gatgaaagaa      120

gatggccgcc tgctggcgag caaatgcgtg accgatgaat gctttttttt tgaacgcctg      180

gaaagcaaca actataacac ctatcgcagc cgcaaatata ccagctggta tgtggcgctg      240

aaacgcaccg gccagtataa actgggcagc aaaaccggcc cgggccagaa agcgattctg      300

tttctgccga tgagcgcgaa aagc                                             324


