                         SEQUENCE LISTING

<110>  Neurimmune AG
 
<120>  Human anti-Tau antibodies

<130>  NE30A83/P-WO

<150>  EP 20 217 601.2
<151>  2020-12-29

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  366
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(366)
<223>  NI-502.4P3 variable heavy chain (VH) sequence

<400>  1
gag gtg cag ctg gtg cag tct gga gca gag gtg aag aag ccc ggg gag         48
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu           
1               5                   10                  15                

tct ctg aag atc tcc tgt aag gtt tct gga tac gac ttt agc aag tac         96
Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr           
            20                  25                  30                    

tgg atc ggc tgg gtg cgc cag atg ccc ggg aaa ggc ctg gag tgg atg        144
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg ctc atc tat cct ggt gac tct gat acc aga tat agt cca tct ttg        192
Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu           
    50                  55                  60                            

gaa ggg caa gtc agc atc tca gcc gac aag tcc atc agc gcc gcc tac        240
Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr           
65                  70                  75                  80            

ttg caa ttc agc agc ctg aag gcc tcg gac agc gcc atg tat tat tgt        288
Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys           
                85                  90                  95                

gtg agg aag gga tat agt gcc tac ctt gga ggg tgg ttc gac ccc tgg        336
Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp           
            100                 105                 110                   

ggc cag gga acc ctg gtc acc gtc tcc tcg                                366
Gly Gln Gly Thr Leu Val Thr Val Ser Ser                                   
        115                 120                                           


<210>  2
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asp Phe Ser Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Glu Gly Gln Val Ser Ile Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Tyr Trp Ile Gly 
1               5   


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5                   


<210>  5
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Gly Tyr Ser Ala Tyr Leu Gly Gly Trp Phe Asp Pro 
1               5                   10              


<210>  6
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-502.4P3 variable light chain (VL) sequence

<400>  6
gac atc cag ttg acc cag tct cca gac tcc ctg gct gcg tct ctg ggc         48
Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly           
1               5                   10                  15                

gag agg gtc acc atc aac tgc agg tcc agc cag aat att ttt tac aac         96
Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn           
            20                  25                  30                    

tcc aac aat aag aac ttc tta gct tgg tat cag cag aaa gca gga cag        144
Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln           
        35                  40                  45                        

tct cct aag ttg ctt att tac tgg gct tct acg cgg gaa tcc ggg gtc        192
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val           
    50                  55                  60                            

cct gac cga ttc agt ggc agc ggc tct ggg aca gat ttc act ctc acc        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr           
65                  70                  75                  80            

atc agc ggc ctg cag gct gga gat gtg gca gtt tat ttc tgt cag caa        288
Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln           
                85                  90                  95                

tat ttt act gat gct ccc act ttc ggc gga ggg acc aag gtg gag atc        336
Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  7
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Arg Ser Ser Gln Asn Ile Phe Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Leu Gln Ala Gly Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Asp Ala Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  8
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Ser Ser Gln Asn Ile Phe Tyr Asn Ser Asn Asn Lys Asn Phe Leu 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Gln Tyr Phe Thr Asp Ala Pro Thr 
1               5                   


<210>  11
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  NI-502.31B6 variable heavy chain (VH) sequence

<400>  11
gag gtg cag ctg ttg cag tct ggg gga ggc gtg gtc cag cct ggg ggg         48
Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gaa gcc tct gga ttc acc ttc agt tcc tat         96
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

tct atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gaa tgg ctg        144
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu           
        35                  40                  45                        

aca ctt atc tca tat aat gga gtc aat aag tat tac gca aag tcc gtg        192
Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val           
    50                  55                  60                            

aag ggc cga ttc gcc atc tcc aga gac gat tcc aag agc aca ctg ttt        240
Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe           
65                  70                  75                  80            

ttg caa atg aac agc ctg aca act gac gac acg gct gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga tgt cca atc ccg cgg gcg gcg tcg tat aga aat gga gat aat        336
Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn           
            100                 105                 110                   

tat ttc gaa ttc ggc cag ggc acc ctg gtc acc gtc tcc tcg                378
Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  12
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Thr Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn 
            100                 105                 110         


Tyr Phe Glu Phe Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  13
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Tyr Ser Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu Ile Ser Tyr Asn Gly Val Asn Lys Tyr Tyr Ala Lys Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys Pro Ile Pro Arg Ala Ala Ser Tyr Arg Asn Gly Asp Asn Tyr Phe 
1               5                   10                  15      


Glu 
    


<210>  16
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-502.31B6 variable light chain (VL) sequence

<400>  16
cag gct gtg gtg act cag gag cca tcg ctc tca gtg tcc cct gga ggg         48
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly           
1               5                   10                  15                

aca gtc aca ctc act tgt gcc ctg agt tct gcc tca gtc tct act tct         96
Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser           
            20                  25                  30                    

tcg tac ccc agc tgg tac cag cag acc cca ggc cag cct cca cgc atg        144
Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met           
        35                  40                  45                        

ctc atc cac aac aca gac act cgc tct tct ggt gtc cct gat cgc ttc        192
Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc atc ctt ggg aag aaa gct gcc ctc acc atc acg ggg gcc        240
Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala           
65                  70                  75                  80            

cag gca gat gat gaa tct gat tac tac tgt gtg gta tat ttg ggg aat        288
Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn           
                85                  90                  95                

ggc ttt tgg gtg ttc ggc gga ggg acc aag ctg acc gtc cta                330
Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  17
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Ser Ser Ala Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Met 
        35                  40                  45              


Leu Ile His Asn Thr Asp Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Lys Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Val Tyr Leu Gly Asn 
                85                  90                  95      


Gly Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  18
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Leu Ser Ser Ala Ser Val Ser Thr Ser Ser Tyr Pro Ser 
1               5                   10                  


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19

Asn Thr Asp Thr Arg Ser Ser 
1               5           


<210>  20
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  20

Val Val Tyr Leu Gly Asn Gly Phe Trp Val 
1               5                   10  


<210>  21
<211>  348
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(348)
<223>  NI-502.8H1 variable heavy chain (VH) sequence

<400>  21
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gtg cag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc cta aga ctc tcc tgt gca gcc tcc gga ttc acc ttt agc atc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr           
            20                  25                  30                    

acc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gct att ctc agt gat ggt agc aca tac tat gca gac tcc gta gag        192
Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu           
    50                  55                  60                            

ggc cga ttc acc atc tcc aga gac aat tcc aag acc acc ctg tat cta        240
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu           
65                  70                  75                  80            

caa atg aac agc ctg aca gcc gag gac acg gcc gta tat tat tgt aca        288
Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr           
                85                  90                  95                

aaa cgt gtt gag ggg agc ttt cgg ggg tgg ggc cag gga acc ctg gtc        336
Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val           
            100                 105                 110                   

acc gtc tcc tcg                                                        348
Thr Val Ser Ser                                                           
        115                                                               


<210>  22
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Arg Val Glu Gly Ser Phe Arg Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  23
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  23

Ile Tyr Thr Met Ser 
1               5   


<210>  24
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Ile Leu Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Glu Gly 
1               5                   10                  15      


<210>  25
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Val Glu Gly Ser Phe Arg Gly 
1               5               


<210>  26
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-502.8H1 variable light chain (VL) sequence

<400>  26
gaa att gtg atg aca cag tct cca ggc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa agc gcc acc ctc tcc tgc agg gcc agt cag agt gtt agc act acc         96
Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr           
            20                  25                  30                    

tac tta gcc tgg tac cag cag aaa cct ggc cag gct ccc agg ctc ctc        144
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc tat ggt gca tcc agc agg gcc act ggc atc cca gac aga ttc agt        192
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg aca gac ttc act ctc aca atc agc aga ctg gag        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gca gtg tat tac tgt cag cag tat ggt ggg tca cgc        288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg           
                85                  90                  95                

ttg atc acc ttc ggc caa ggg aca cga ctg gag att aaa                    327
Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys                       
            100                 105                                       


<210>  27
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Arg 
                85                  90                  95      


Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210>  28
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Ala Ser Gln Ser Val Ser Thr Thr Tyr Leu Ala 
1               5                   10          


<210>  29
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Gln Tyr Gly Gly Ser Arg Leu Ile Thr 
1               5                   10  


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope recognized by NI-502.4P3

<400>  31

Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
1               5                   10      


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope recognized by NI-502.4P3

<400>  32

Pro Met Pro Asp Leu Lys Asn 
1               5           


<210>  33
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope of phosphorylated Tau peptide pS202/pT205 recognized by 
       NI-502.31B6


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  PHOSPHORYLATION

<400>  33

Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser 
1               5                   10                  15      


Arg Thr 
        


<210>  34
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope of phosphorylated Tau peptide pT212/pS214 recognized by 
       NI-502.8H1


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  PHOSPHORYLATION

<400>  34

Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro 
1               5                   10                  15      


Thr Arg 
        


<210>  35
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic phosphorylated Tau peptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  PHOSPHORYLATION

<400>  35

Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser 
1               5                   10                  15      


Pro Arg His Leu Ser Asn Val 
            20              


<210>  36
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic phosphorylated tau peptide


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  PHOSPHORYLATION

<400>  36

Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro 
1               5                   10                  15      


Ser Ser 
        


<210>  37
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic phosphorylated tau peptide


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  PHOSPHORYLATION

<400>  37

Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr 
1               5                   10                  15      


Leu Ala 
        


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of peptide 54

<400>  38

Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of peptide 55

<400>  39

Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr 
1               5                   10                  15  


<210>  40
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence of peptides 54 and 55

<400>  40

Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val 
1               5                   10                  15      


Val Arg Thr 
            


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of peptide 61

<400>  41

Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of peptide 62

<400>  42

Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of peptide 63

<400>  43

Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr 
1               5                   10                  15  


<210>  44
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence of peptides 61, 62 and 63

<400>  44

Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
1               5                   10                  15      


Lys Ser Lys Ile Gly Ser Thr 
            20              


