﻿               SEQUENCE LISTING

<110> CeMM Forschungszentrum für Molekulare Medizin GmbH
      Medizinische Universität Wien
      Université de Lausanne

<120> ANTI-APRIL ANTIBODIES AND USE THEREOF

<130> AB1373 PCT BS

<150> EP20 217 536.0
<151> 2020-12-29

<160> 102

<170> BiSSAP 1.3.6

<210> 1
<211> 146
<212> PRT
<213> Homo sapiens


<220> 
<223> APRIL

<400> 1
Ala Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His Leu 
1               5                   10                  15      
Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val 
            20                  25                  30          
Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
        35                  40                  45              
Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
    50                  55                  60                  
Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
65                  70                  75                  80  
Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
                85                  90                  95      
Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
            100                 105                 110         
Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
        115                 120                 125             
Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val 
    130                 135                 140                 
Lys Leu 
145     

<210> 2
<211> 250
<212> PRT
<213> Homo sapiens


<220> 
<223> Unprocessed APRIL

<400> 2
Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      
Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          
Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              
Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  
Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  
Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      
Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         
Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             
Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 
Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 
Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     
Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         
Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             
Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 
Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 
His Gly Thr Phe Leu Gly Phe Val Lys Leu 
                245                 250 

<210> 3
<211> 146
<212> PRT
<213> Homo sapiens


<220> 
<223> nc-APRIL

<400> 3
Ala Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His Leu 
1               5                   10                  15      
Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val 
            20                  25                  30          
Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
        35                  40                  45              
Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
    50                  55                  60                  
Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
65                  70                  75                  80  
Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
                85                  90                  95      
Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
            100                 105                 110         
Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
        115                 120                 125             
Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val 
    130                 135                 140                 
Lys Leu 
145     

<210> 4
<211> 145
<212> PRT
<213> Artificial Sequence


<220> 
<223> nc-APRIL

<400> 4
Ala Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His Leu 
1               5                   10                  15      
Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val 
            20                  25                  30          
Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
        35                  40                  45              
Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
    50                  55                  60                  
Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
65                  70                  75                  80  
Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
                85                  90                  95      
Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
            100                 105                 110         
Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
        115                 120                 125             
Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val 
    130                 135                 140                 
Lys 
145 

<210> 5
<211> 144
<212> PRT
<213> Artificial Sequence


<220> 
<223> nc-APRIL

<400> 5
Ala Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His Leu 
1               5                   10                  15      
Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val 
            20                  25                  30          
Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
        35                  40                  45              
Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
    50                  55                  60                  
Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
65                  70                  75                  80  
Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
                85                  90                  95      
Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
            100                 105                 110         
Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
        115                 120                 125             
Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val 
    130                 135                 140                 



<210> 6
<211> 143
<212> PRT
<213> Artificial Sequence


<220> 
<223> nc-APRIL

<400> 6
Ala Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His Leu 
1               5                   10                  15      
Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val 
            20                  25                  30          
Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
        35                  40                  45              
Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
    50                  55                  60                  
Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
65                  70                  75                  80  
Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
                85                  90                  95      
Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
            100                 105                 110         
Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
        115                 120                 125             
Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe 
    130                 135                 140             

<210> 7
<211> 122
<212> PRT
<213> Mus musculus


<220> 
<223> VH 104

<400> 7
Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          
Asn Met Ser Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Ile Ile Ser Pro Tyr Tyr Gly Thr Thr Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asn Tyr Gly Gly Asn Leu Asp Tyr Tyr Ser Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         

<210> 8
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VH 104

<400> 8
Gly Tyr Ser Phe Thr Asp Tyr Asn 
1               5               

<210> 9
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR2 VH 104

<400> 9
Ile Ser Pro Tyr Tyr Gly Thr Thr 
1               5               

<210> 10
<211> 15
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VH 104

<400> 10
Ala Arg Asn Tyr Gly Gly Asn Leu Asp Tyr Tyr Ser Met Asp Tyr 
1               5                   10                  15  

<210> 11
<211> 107
<212> PRT
<213> Mus musculus


<220> 
<223> VL 104

<400> 11
Ser Ile Val Met Thr Gln Thr Pro Asn Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      
Asp Arg Val Thr Met Thr Cys Lys Ala Ser Gln Thr Val Ser Asn Asp 
            20                  25                  30          
Val Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Thr Thr Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Ser Ser Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 12
<211> 6
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VL 104

<400> 12
Gln Thr Val Ser Asn Asp 
1               5       

<210> 13
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VL 104

<400> 13
Gln Gln Asp Ser Ser Phe Pro Leu Thr 
1               5                   

<210> 14
<211> 113
<212> PRT
<213> Mus musculus


<220> 
<223> VH 108

<400> 14
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Pro Leu Ile Ser Tyr 
            20                  25                  30          
Gly Val Glu Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Ile Ile Trp Asp Asp Gly Val Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  
Ser Arg Leu Arg Ile Ser Lys Asp Asn Ser Lys Arg Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Pro Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ala 
    

<210> 15
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VH 108

<400> 15
Gly Phe Pro Leu Ile Ser Tyr Gly 
1               5               

<210> 16
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> CDR2 VH 108

<400> 16
Ile Trp Asp Asp Gly Val Thr 
1               5           

<210> 17
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VH 108

<400> 17
Ala Arg Arg Gly Phe Ala Tyr 
1               5           

<210> 18
<211> 107
<212> PRT
<213> Mus musculus


<220> 
<223> VL 108

<220> 
<221> VARIANT
<222> 4
<223> any amino acid

<400> 18
Asp Ile Val Xaa Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Phe 
            20                  25                  30          
Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ser Thr His Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 19
<211> 6
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VL 108

<400> 19
Gln Glu Ile Ser Gly Phe 
1               5       

<210> 20
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VL 108

<400> 20
Leu Gln Tyr Ser Thr His Pro Tyr Thr 
1               5                   

<210> 21
<211> 121
<212> PRT
<213> Mus musculus


<220> 
<223> VH 110

<400> 21
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Leu Thr His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  
Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ile His Ile Leu Asp Asn Ser Gly Tyr Val Gly Ala Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     

<210> 22
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VH 110

<400> 22
Gly Phe Ser Leu Ser Thr Phe Gly Met 
1               5                   

<210> 23
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> CDR2 VH 110

<400> 23
Ile Trp Trp Asp Asp Asp Lys 
1               5           

<210> 24
<211> 13
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VH 110

<400> 24
Ile His Ile Leu Asp Asn Ser Gly Tyr Val Gly Ala Tyr 
1               5                   10              

<210> 25
<211> 109
<212> PRT
<213> Mus musculus


<220> 
<223> VL 110

<400> 25
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Ser Gly Ala Val Thr Ile Ser 
            20                  25                  30          
Asn Phe Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              
Leu Ile Ala Gly Thr Asn Asn Arg Gly Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Ile Gly Asp Arg Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ser Leu Trp Tyr Arg Asp 
                85                  90                  95      
His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210> 26
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VL 110

<400> 26
Ser Gly Ala Val Thr Ile Ser Asn Phe 
1               5                   

<210> 27
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VL 110

<400> 27
Ser Leu Trp Tyr Arg Asp His Trp Val 
1               5                   

<210> 28
<211> 121
<212> PRT
<213> Mus musculus


<220> 
<223> VH 115

<400> 28
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          
Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Leu Ala His Ile Trp Trp Asp Asp Asp Asn Tyr Tyr Thr Pro Ala 
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  
Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ser Arg Ala His Tyr Tyr Asp Gly Ile His Phe Asp Phe Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     

<210> 29
<211> 10
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VH 115

<400> 29
Gly Phe Ser Leu Ser Thr Phe Gly Leu Gly 
1               5                   10  

<210> 30
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> CDR2 VH 115

<400> 30
Ile Trp Trp Asp Asp Asp Asn 
1               5           

<210> 31
<211> 13
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VH 115

<400> 31
Ser Arg Ala His Tyr Tyr Asp Gly Ile His Phe Asp Phe 
1               5                   10              

<210> 32
<211> 109
<212> PRT
<213> Mus musculus


<220> 
<223> VL 115

<400> 32
Gln Thr Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Thr Val Thr Thr Ser 
            20                  25                  30          
Asn Phe Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              
Leu Ile Ser Gly Thr Ser Asn Arg Gly Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210> 33
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VL 115

<400> 33
Thr Gly Thr Val Thr Thr Ser Asn Phe 
1               5                   

<210> 34
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VL 115

<400> 34
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   

<210> 35
<211> 117
<212> PRT
<213> Mus musculus


<220> 
<223> VH 2C8

<220> 
<221> VARIANT
<222> 3
<223> any amino acid

<400> 35
Glu Val Xaa Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          
Tyr Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Pro Gly Thr Asp Gly Ile Thr Phe Asn Gln Lys Phe 
    50                  55                  60                  
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Lys Ser Leu Lys Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Thr Asp Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 36
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VH 2C8

<400> 36
Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               

<210> 37
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR2 VH 2C8

<400> 37
Ile Asn Pro Gly Thr Asp Gly Ile 
1               5               

<210> 38
<211> 10
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VH 2C8

<400> 38
Ala Thr Thr Asp Tyr Tyr Gly Met Asp Tyr 
1               5                   10  

<210> 39
<211> 112
<212> PRT
<213> Mus musculus


<220> 
<223> VL 2C8

<220> 
<221> VARIANT
<222> 4
<223> any amino acid

<400> 39
Asp Ile Val Xaa Thr Gln Ser Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 40
<211> 11
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VL 2C8

<400> 40
Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      

<210> 41
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VL 2C8

<400> 41
Trp Gln Gly Thr His Phe Pro Tyr Thr 
1               5                   

<210> 42
<211> 115
<212> PRT
<213> Mus musculus


<220> 
<223> VH Aprily 1

<400> 42
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Asn Phe Lys Thr Ser 
            20                  25                  30          
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asp Thr Tyr Ala Gly Val Pro Thr Tyr Thr Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Thr Thr Ala Phe 
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Glu Pro Gly Thr Asp Asn Trp Gly Gln Gly Thr Ser Leu Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 43
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VH Aprily 1

<400> 43
Gly Tyr Asn Phe Lys Thr Ser Gly 
1               5               

<210> 44
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR2 VH Aprily 1

<400> 44
Ile Asp Thr Tyr Ala Gly Val Pro 
1               5               

<210> 45
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VH Aprily 1

<400> 45
Ala Arg Glu Pro Gly Thr Asp Asn 
1               5               

<210> 46
<211> 111
<212> PRT
<213> Mus musculus


<220> 
<223> VL APRILY 1

<400> 46
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Gly Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  
Pro Met Glu Glu Asp Asp Pro Ala Met Tyr Phe Cys Gln Gln Thr Lys 
                85                  90                  95      
Glu Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 47
<211> 10
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VL APRILY 1

<400> 47
Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  

<210> 48
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VL APRILY 1

<400> 48
Gln Gln Thr Lys Glu Val Pro Phe Thr 
1               5                   

<210> 49
<211> 115
<212> PRT
<213> Mus musculus


<220> 
<223> VH APRILY 2

<400> 49
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Thr Ser 
            20                  25                  30          
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asp Ala Tyr Ala Gly Ile Pro Thr Tyr Thr Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Asp Thr Ser Ala Thr Thr Ala Phe 
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Glu Pro Gly Thr Asp Asn Trp Gly Gln Gly Thr Ser Leu Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 50
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VH Aprily 2

<400> 50
Gly Tyr Thr Phe Lys Thr Ser Gly 
1               5               

<210> 51
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR2 VH Aprily 2

<400> 51
Ile Asp Ala Tyr Ala Gly Ile Pro 
1               5               

<210> 52
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VH Aprily 2

<400> 52
Ala Arg Glu Pro Gly Thr Asp Asn 
1               5               

<210> 53
<211> 112
<212> PRT
<213> Mus musculus


<220> 
<223> VL Aprily 2

<400> 53
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Phe Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Ala His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         



<210> 54
<211> 11
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VL Aprily 2

<400> 54
Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      

<210> 55
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VL Aprily 2

<400> 55
Trp Gln Gly Ala His Phe Pro Gln Thr 
1               5                   

<210> 56
<211> 114
<212> PRT
<213> Mus musculus


<220> 
<223> VH Aprily 5

<400> 56
Glu Val Gln Leu Glu Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Ser Val His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Glu Thr Gly Asp Pro Ser Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Met Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Ile His Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 57
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VH Aprily 5

<400> 57
Gly Tyr Thr Phe Thr Asp Tyr Ser 
1               5               

<210> 58
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> CDR2 VH Aprily 5

<400> 58
Ile Asn Thr Glu Thr Gly Asp Pro 
1               5               

<210> 59
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VH Aprily 5

<400> 59
Ala Ile His Ala Met Asp Tyr 
1               5           

<210> 60
<211> 107
<212> PRT
<213> Mus musculus


<220> 
<223> VL Aprily 5

<220> 
<221> VARIANT
<222> 4
<223> any amino acid

<400> 60
Asp Ile Val Xaa Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          
Leu Thr Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly His Ala Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105         

<210> 61
<211> 6
<212> PRT
<213> Mus musculus


<220> 
<223> CDR1 VL Aprily 5

<400> 61
Gln Asn Ile Asn Val Trp 
1               5       

<210> 62
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> CDR3 VL Aprily 5

<400> 62
Gln Gln Gly His Ala Tyr Pro Leu Thr 
1               5                   

<210> 63
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> Epitope on APRIL

<400> 63
His Leu Val Pro Asn Ile 
1               5       

<210> 64
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> Epitope on APRIL

<400> 64
Pro Ala Leu Arg Arg Gly 
1               5       

<210> 65
<211> 366
<212> DNA
<213> Mus musculus


<220> 
<223> VH 104

<400> 65
gagttccagc tgcagcagtc tggacctgag ctggtgaagc ctggcgcctc agtgaagatt      60

tcctgcaagg cttctggtta ctctttcact gactacaata tgagctgggt gaagcagagc     120

aatggaaaga gccttgaatg gattggaata attagtcctt actatggtac tactacctac     180

aatcagaact tcaagggcaa ggccacattg actgtagacc aatcttccag cacagcctac     240

atgcacctca acagcctgac atctgaggac tctgcagtct attactgtgc aagaaactac     300

ggtggtaact tggattatta tagtatggac tactggggtc aaggaacctc agtcaccgtc     360

tcctca                                                                366


<210> 66
<211> 321
<212> DNA
<213> Mus musculus


<220> 
<223> VL 104

<400> 66
agtattgtga tgacccagac tcccaacttc ctgcttgttt cagcaggaga cagggttacc      60

atgacctgca aggccagtca gactgtgagt aatgatgtag gttggtacca acagaagcct     120

gggcagtctc ctaaactgct gatatattat gcatccaatc gctacactgg agtccctgat     180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcaccac tgtgcaggcg     240

gaagacctgg cagtttattt ctgtcagcag gattctagtt ttccgctcac gttcggtgct     300

gggaccaagc tggaaataaa a                                               321


<210> 67
<211> 339
<212> DNA
<213> Mus musculus


<220> 
<223> VH 108

<400> 67
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc      60

acttgcactg tctctgggtt tccattaatc agctatggtg tagagtgggt tcgccagcct     120

ccaggaaagg gtctggagtg gctgggaatc atatgggatg atggagtcac aaattataat     180

tcagctctca tgtccagact gcggatcagc aaagacaact ccaagcgcca agtcttctta     240

aaaatgaata gtctccaacc tgatgacaca gccatatact attgtgccag aagaggtttt     300

gcttactggg gccaagggac tctggtcact gtctctgca                            339


<210> 68
<211> 321
<212> DNA
<213> Mus musculus


<220> 
<223> VL 108

<220> 
<221> variation
<222> 10
<223> /replace="any nucleotide"

<400> 68
gatattgtgn tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt      60

ctcacttgtc gggcaagtca ggaaattagt ggtttcttaa gctggcttca gcagaaacca     120

gatggaacta tcaaacgcct gatctacgcc gcatccagtt tagattctgg tgtcccaaaa     180

aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag ccttgagtct     240

gaagattttg cagactatta ctgtctacaa tattctactc atccgtacac gttcggaggg     300

gggaccaagc tggaaataaa a                                               321


<210> 69
<211> 363
<212> DNA
<213> Mus musculus


<220> 
<223> VH 110

<400> 69
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg      60

acttgttctt tctctgggtt ttcactgagc acttttggta tgggtgtagg ctggattcgt     120

cagccttcag ggaagggtct ggagtggctg acacacattt ggtgggatga tgataagtac     180

tataatccag ccctgaagag tcggctcaca atctccaagg atacctccaa aaaccaggta     240

ttcctcaaga tcgccaatgt ggacactgca gatactgcca catactactg tattcacatc     300

ctagacaact caggttacgt gggcgcttac tggggccaag ggactctggt cactgtctct     360

gca                                                                   363


<210> 70
<211> 327
<212> DNA
<213> Mus musculus


<220> 
<223> VL 110

<400> 70
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc      60

acttgtcgct caagttctgg ggctgttaca atcagtaact ttgccaactg ggtccaagaa     120

aaaccagatc atttattcac tggtctaata gctggtacca acaaccgagg tccaggtgtt     180

cctgccagat tctcaggctc cctgattgga gacagggctg ccctcaccat cacaggggca     240

cagactgagg atgaggcaat atatttctgt tctctatggt acagagacca ctgggtgttc     300

ggtggaggaa ccaaactgac tgtccta                                         327


<210> 71
<211> 363
<212> DNA
<213> Mus musculus


<220> 
<223> VH 115

<400> 71
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg      60

acttgttctt tctctgggtt ttcactcagc acttttggtt tgggtgtagg ctggattcgt     120

cagccttcag ggaagggtct ggagtggctg gcacacattt ggtgggatga tgataactac     180

tataccccgg ccctgaagag tcggctcaca gtctccaagg atacctccaa aaaccaggtt     240

ttcctcaaga tcgccaatgt ggacactgca gatactgcca catactactg ttctcgcgcc     300

cattactatg atggtatcca ctttgacttc tggggccaag gcaccactct cacagtctcc     360

tca                                                                   363


<210> 72
<211> 327
<212> DNA
<213> Mus musculus


<220> 
<223> VL 115

<400> 72
cagactgttg tgactcagga atctgcactc accacatccc ctggtgaaac agtcacactc      60

acttgtcgct caagtactgg gactgttaca actagtaact ttgccaactg ggtccaagaa     120

aaaccagatc atttattcac tggtctaata agtggtacca gcaaccgagg tccaggtgtt     180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca     240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaatca ctgggtgttc     300

ggtggaggaa ccaaactgac tgtccta                                         327


<210> 73
<211> 351
<212> DNA
<213> Mus musculus


<220> 
<223> VH 2C8

<220> 
<221> variation
<222> 6
<223> /replace="any nucleotide"

<220> 
<221> variation
<222> 7
<223> /replace="any nucleotide"

<400> 73
gaggtnnagc tggaggagtc tggacctgaa ctggtgaagc ctggggcttc agtgaagata      60

tcctgcaagg cttctggtta ctcattcact ggctattaca tgaactgggt gaagcaaagt     120

cctgaaaaga gccttgagtg gattggagag attaatcctg gcactgatgg tattaccttt     180

aaccagaagt tcaaggccaa ggccacattg actgtagaca aatcctccag cacagcctac     240

atgcagctca aaagcctgaa atctgaggac tctgcagtct attactgtgc gactacggat     300

tactatggca tggactactg gggtcaagga acctcagtca ccgtctcctc a              351


<210> 74
<211> 336
<212> DNA
<213> Mus musculus


<220> 
<223> VL 2C8

<400> 74
gatattgtgm tgacccagtc tccactcact ttgtcggtta ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg     120

ttattacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac ccattttccg     300

tacacgttcg gaggggggac caagctggaa ataaaa                               336


<210> 75
<211> 345
<212> DNA
<213> Mus musculus


<220> 
<223> VH Aprily 1

<400> 75
cagatccagt tggtacagtc tggacctgaa ctgaagaagc ctggagagac agtcaggatc      60

tcctgcaagg cctctggcta taacttcaaa acctctggaa tgagctgggt gaaacaggca     120

ccaggaaagg gtttaaagtg gatgggctgg atagacacct acgctggagt gccaacatat     180

actgatgact tcaagggacg gtttgtcttc tctttggaaa cctctgccac cactgccttt     240

ttgcagatca acaacctcaa aaatgaggac acgggaacat atttctgtgc aagagaacct     300

gggacagaca actggggcca aggcacatct ctcactgtct cctca                     345


<210> 76
<211> 333
<212> DNA
<213> Mus musculus


<220> 
<223> VL Aprily 1

<400> 76
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc     120

caacagaaac caggacagcc acccaaactc ctcatctatg gtgcatccaa ccaaggatcc     180

ggggtccctg ccaggtttag tggcagtgga tctgggacag acttcagcct caacatccat     240

cctatggagg aggatgatcc tgcaatgtat ttctgtcagc aaactaagga ggttccgttc     300

acgttcggag gggggaccaa gctggaaata aaa                                  333


<210> 77
<211> 345
<212> DNA
<213> Mus musculus


<220> 
<223> VH Aprily 2

<400> 77
cagatccagt tggtacagtc tggacctgag ctgaagaagc ctggagagac agtcaggatc      60

tcctgcaagg cctctggcta taccttcaaa acctctggaa tgagctgggt gaaacaggca     120

ccaggaaagg gtttaaagtg gatgggctgg atagacgcct acgctggaat accaacatat     180

actgatgact tcaagggacg gtttgccttc tctttggaca cctctgccac cactgccttt     240

ttgcagatca acaacctcaa aaatgaggac acgggaacat atttctgtgc aagagaacct     300

gggacagaca actggggcca aggcacatct ctcactgtct cctca                     345


<210> 78
<211> 336
<212> DNA
<213> Mus musculus


<220> 
<223> VL Aprily 2

<400> 78
gatgtcgtga tgacccagac cccactcact ttgtcggtta ccattggaca accagcctcc      60

atttcttgta agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctggagtcc ctgacaggtt cattggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggattt tattattgct ggcaaggtgc acattttcct     300

cagacgttcg gtggaggcac caaggtggaa atcaaa                               336


<210> 79
<211> 342
<212> DNA
<213> Mus musculus


<220> 
<223> VH Aprily 5

<220> 
<221> variation
<222> 6
<223> /replace="any nucleotide"

<400> 79
gaggtncagc tggaggagtc tggacctgag ctgaaaaagc ctggagagac agtcaagatc      60

tcctgcaagg cttctggtta taccttcaca gactattcag tgcactgggt gaggcaaact     120

ccaggcaagg gtttaaagtg gatgggctgg ataaacactg agactggtga cccatcatat     180

gcagatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat     240

ttgcagatca tgaacctcaa aaatgaggac acggctacat atttctgtgc tatccatgct     300

atggactact ggggtcaagg aacctcagtc accgtctcct ca                        342


<210> 80
<211> 321
<212> DNA
<213> Mus musculus


<220> 
<223> VL Aprily 5

<400> 80
gatattgtgm tgacccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc      60

atcacttgcc atgccagtca gaacattaat gtttggttaa cctggtacca gcagaaacca     120

ggaaatattc ctaaactatt gatctataag gcttccaact tgcacacagg cgtcccatca     180

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct     240

gaagacattg ccacttacta ctgtcaacag ggtcatgctt atcctctgac gttcggtgga     300

ggcaccaagc tggaaatcag a                                               321


<210> 81
<211> 411
<212> DNA
<213> Artificial Sequence


<220> 
<223> ps1307

<400> 81
cactctgtcc tgcacctggt tcccattaac gccacctcca aggatgactc cgatgtgaca      60

gaggtgatgt ggcaaccagc tcttaggcgt gggagaggcc tacaggccca aggatatggt     120

gtccgaatcc aggatgctgg agtttatctg ctgtatagcc aggtcctgtt tcaagacgtg     180

actttcacca tgggtcaggt ggtgtctcga gaaggccaag gaaggcagga gactctattc     240

cgatgtataa gaagtatgcc ctcccacccg gaccgggcct acaacagctg ctatagcgca     300

ggtgtcttcc atttacacca aggggatatt ctgagtgtca taattccccg ggcaagggcg     360

aaacttaacc tctctccaca tggaaccttc ctggggtttg tgaaactgtg a              411


<210> 82
<211> 408
<212> DNA
<213> Artificial Sequence


<220> 
<223> ps4185

<400> 82
cactctgtcc tgcacctggt tcccattaac gccacctcca aggatgactc cgatgtgaca      60

gaggtgatgt ggcaaccagc tcttaggcgt gggagaggcc tacaggccca aggatatggt     120

gtccgaatcc aggatgctgg agtttatctg ctgtatagcc aggtcctgtt tcaagacgtg     180

actttcacca tgggtcaggt ggtgtctcga gaaggccaag gaaggcagga gactctattc     240

cgatgtataa gaagtatgcc ctcccacccg gaccgggcct acaacagctg ctatagcgca     300

ggtgtcttcc atttacacca aggggatatt ctgagtgtca taattccccg ggcaagggcg     360

aaacttaacc tctctccaca tggaaccttc ctggggtttg tgaaatga                  408


<210> 83
<211> 405
<212> DNA
<213> Artificial Sequence


<220> 
<223> ps4186

<400> 83
cactctgtcc tgcacctggt tcccattaac gccacctcca aggatgactc cgatgtgaca      60

gaggtgatgt ggcaaccagc tcttaggcgt gggagaggcc tacaggccca aggatatggt     120

gtccgaatcc aggatgctgg agtttatctg ctgtatagcc aggtcctgtt tcaagacgtg     180

actttcacca tgggtcaggt ggtgtctcga gaaggccaag gaaggcagga gactctattc     240

cgatgtataa gaagtatgcc ctcccacccg gaccgggcct acaacagctg ctatagcgca     300

ggtgtcttcc atttacacca aggggatatt ctgagtgtca taattccccg ggcaagggcg     360

aaacttaacc tctctccaca tggaaccttc ctggggtttg tgtga                     405


<210> 84
<211> 402
<212> DNA
<213> Artificial Sequence


<220> 
<223> ps4187

<400> 84
cactctgtcc tgcacctggt tcccattaac gccacctcca aggatgactc cgatgtgaca      60

gaggtgatgt ggcaaccagc tcttaggcgt gggagaggcc tacaggccca aggatatggt     120

gtccgaatcc aggatgctgg agtttatctg ctgtatagcc aggtcctgtt tcaagacgtg     180

actttcacca tgggtcaggt ggtgtctcga gaaggccaag gaaggcagga gactctattc     240

cgatgtataa gaagtatgcc ctcccacccg gaccgggcct acaacagctg ctatagcgca     300

ggtgtcttcc atttacacca aggggatatt ctgagtgtca taattccccg ggcaagggcg     360

aaacttaacc tctctccaca tggaaccttc ctggggtttt ga                        402


<210> 85
<211> 399
<212> DNA
<213> Artificial Sequence


<220> 
<223> ps4188

<400> 85
cactctgtcc tgcacctggt tcccattaac gccacctcca aggatgactc cgatgtgaca      60

gaggtgatgt ggcaaccagc tcttaggcgt gggagaggcc tacaggccca aggatatggt     120

gtccgaatcc aggatgctgg agtttatctg ctgtatagcc aggtcctgtt tcaagacgtg     180

actttcacca tgggtcaggt ggtgtctcga gaaggccaag gaaggcagga gactctattc     240

cgatgtataa gaagtatgcc ctcccacccg gaccgggcct acaacagctg ctatagcgca     300

ggtgtcttcc atttacacca aggggatatt ctgagtgtca taattccccg ggcaagggcg     360

aaacttaacc tctctccaca tggaaccttc ctggggtga                            399


<210> 86
<211> 1230
<212> DNA
<213> Artificial Sequence


<220> 
<223> ps1307 (full Fc-APRIL)

<400> 86
atggctatca tctacctcat cctcctgttc accgctgtgc ggggcctcga caaaactcac      60

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     120

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     180

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     240

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     300

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     360

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     420

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     480

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     540

gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc     600

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     660

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     720

ccgggtaaaa gatctccgca gccgcagccg aaaccgcagc cgaaaccgga accggaagga     780

tctctggagg tgctgttcca ggggcccgga tccctgcagc actctgtcct gcacctggtt     840

cccattaacg ccacctccaa ggatgactcc gatgtgacag aggtgatgtg gcaaccagct     900

cttaggcgtg ggagaggcct acaggcccaa ggatatggtg tccgaatcca ggatgctgga     960

gtttatctgc tgtatagcca ggtcctgttt caagacgtga ctttcaccat gggtcaggtg    1020

gtgtctcgag aaggccaagg aaggcaggag actctattcc gatgtataag aagtatgccc    1080

tcccacccgg accgggccta caacagctgc tatagcgcag gtgtcttcca tttacaccaa    1140

ggggatattc tgagtgtcat aattccccgg gcaagggcga aacttaacct ctctccacat    1200

ggaaccttcc tggggtttgt gaaactgtga                                     1230


<210> 87
<211> 1227
<212> DNA
<213> Artificial Sequence


<220> 
<223> ps4185 (full Fc-APRIL)

<400> 87
atggctatca tctacctcat cctcctgttc accgctgtgc ggggcctcga caaaactcac      60

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     120

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     180

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     240

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     300

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     360

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     420

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     480

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     540

gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc     600

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     660

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     720

ccgggtaaaa gatctccgca gccgcagccg aaaccgcagc cgaaaccgga accggaagga     780

tctctggagg tgctgttcca ggggcccgga tccctgcagc actctgtcct gcacctggtt     840

cccattaacg ccacctccaa ggatgactcc gatgtgacag aggtgatgtg gcaaccagct     900

cttaggcgtg ggagaggcct acaggcccaa ggatatggtg tccgaatcca ggatgctgga     960

gtttatctgc tgtatagcca ggtcctgttt caagacgtga ctttcaccat gggtcaggtg    1020

gtgtctcgag aaggccaagg aaggcaggag actctattcc gatgtataag aagtatgccc    1080

tcccacccgg accgggccta caacagctgc tatagcgcag gtgtcttcca tttacaccaa    1140

ggggatattc tgagtgtcat aattccccgg gcaagggcga aacttaacct ctctccacat    1200

ggaaccttcc tggggtttgt gaaatga                                        1227


<210> 88
<211> 1224
<212> DNA
<213> Artificial Sequence


<220> 
<223> ps4186 (full Fc-APRIL)

<400> 88
atggctatca tctacctcat cctcctgttc accgctgtgc ggggcctcga caaaactcac      60

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     120

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     180

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     240

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     300

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     360

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     420

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     480

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     540

gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc     600

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     660

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     720

ccgggtaaaa gatctccgca gccgcagccg aaaccgcagc cgaaaccgga accggaagga     780

tctctggagg tgctgttcca ggggcccgga tccctgcagc actctgtcct gcacctggtt     840

cccattaacg ccacctccaa ggatgactcc gatgtgacag aggtgatgtg gcaaccagct     900

cttaggcgtg ggagaggcct acaggcccaa ggatatggtg tccgaatcca ggatgctgga     960

gtttatctgc tgtatagcca ggtcctgttt caagacgtga ctttcaccat gggtcaggtg    1020

gtgtctcgag aaggccaagg aaggcaggag actctattcc gatgtataag aagtatgccc    1080

tcccacccgg accgggccta caacagctgc tatagcgcag gtgtcttcca tttacaccaa    1140

ggggatattc tgagtgtcat aattccccgg gcaagggcga aacttaacct ctctccacat    1200

ggaaccttcc tggggtttgt gtga                                           1224


<210> 89
<211> 1221
<212> DNA
<213> Artificial Sequence


<220> 
<223> ps4187 (full Fc-APRIL)

<400> 89
atggctatca tctacctcat cctcctgttc accgctgtgc ggggcctcga caaaactcac      60

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     120

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     180

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     240

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     300

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     360

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     420

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     480

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     540

gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc     600

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     660

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     720

ccgggtaaaa gatctccgca gccgcagccg aaaccgcagc cgaaaccgga accggaagga     780

tctctggagg tgctgttcca ggggcccgga tccctgcagc actctgtcct gcacctggtt     840

cccattaacg ccacctccaa ggatgactcc gatgtgacag aggtgatgtg gcaaccagct     900

cttaggcgtg ggagaggcct acaggcccaa ggatatggtg tccgaatcca ggatgctgga     960

gtttatctgc tgtatagcca ggtcctgttt caagacgtga ctttcaccat gggtcaggtg    1020

gtgtctcgag aaggccaagg aaggcaggag actctattcc gatgtataag aagtatgccc    1080

tcccacccgg accgggccta caacagctgc tatagcgcag gtgtcttcca tttacaccaa    1140

ggggatattc tgagtgtcat aattccccgg gcaagggcga aacttaacct ctctccacat    1200

ggaaccttcc tggggttttg a                                              1221


<210> 90
<211> 1218
<212> DNA
<213> Artificial Sequence


<220> 
<223> ps4188 (full Fc-APRIL)

<400> 90
atggctatca tctacctcat cctcctgttc accgctgtgc ggggcctcga caaaactcac      60

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     120

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     180

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     240

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     300

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     360

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     420

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     480

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     540

gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc     600

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     660

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     720

ccgggtaaaa gatctccgca gccgcagccg aaaccgcagc cgaaaccgga accggaagga     780

tctctggagg tgctgttcca ggggcccgga tccctgcagc actctgtcct gcacctggtt     840

cccattaacg ccacctccaa ggatgactcc gatgtgacag aggtgatgtg gcaaccagct     900

cttaggcgtg ggagaggcct acaggcccaa ggatatggtg tccgaatcca ggatgctgga     960

gtttatctgc tgtatagcca ggtcctgttt caagacgtga ctttcaccat gggtcaggtg    1020

gtgtctcgag aaggccaagg aaggcaggag actctattcc gatgtataag aagtatgccc    1080

tcccacccgg accgggccta caacagctgc tatagcgcag gtgtcttcca tttacaccaa    1140

ggggatattc tgagtgtcat aattccccgg gcaagggcga aacttaacct ctctccacat    1200

ggaaccttcc tggggtga                                                  1218


<210> 91
<211> 409
<212> PRT
<213> Artificial Sequence


<220> 
<223> ps1307 (full Fc-APRIL)

<400> 91
Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Leu 
1               5                   10                  15      
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            20                  25                  30          
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        35                  40                  45              
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    50                  55                  60                  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
65                  70                  75                  80  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                85                  90                  95      
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            100                 105                 110         
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        115                 120                 125             
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    130                 135                 140                 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
145                 150                 155                 160 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                165                 170                 175     
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            180                 185                 190         
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        195                 200                 205             
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    210                 215                 220                 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
225                 230                 235                 240 
Pro Gly Lys Arg Ser Pro Gln Pro Gln Pro Lys Pro Gln Pro Lys Pro 
                245                 250                 255     
Glu Pro Glu Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Ser Leu 
            260                 265                 270         
Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp 
        275                 280                 285             
Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly 
    290                 295                 300                 
Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly 
305                 310                 315                 320 
Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr 
                325                 330                 335     
Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu 
            340                 345                 350         
Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn 
        355                 360                 365             
Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu 
    370                 375                 380                 
Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His 
385                 390                 395                 400 
Gly Thr Phe Leu Gly Phe Val Lys Leu 
                405                 

<210> 92
<211> 408
<212> PRT
<213> Artificial Sequence


<220> 
<223> ps4185 ( (full Fc-APRIL)

<400> 92
Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Leu 
1               5                   10                  15      
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            20                  25                  30          
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        35                  40                  45              
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    50                  55                  60                  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
65                  70                  75                  80  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                85                  90                  95      
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            100                 105                 110         
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        115                 120                 125             
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    130                 135                 140                 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
145                 150                 155                 160 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                165                 170                 175     
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            180                 185                 190         
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        195                 200                 205             
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    210                 215                 220                 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
225                 230                 235                 240 
Pro Gly Lys Arg Ser Pro Gln Pro Gln Pro Lys Pro Gln Pro Lys Pro 
                245                 250                 255     
Glu Pro Glu Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Ser Leu 
            260                 265                 270         
Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp 
        275                 280                 285             
Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly 
    290                 295                 300                 
Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly 
305                 310                 315                 320 
Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr 
                325                 330                 335     
Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu 
            340                 345                 350         
Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn 
        355                 360                 365             
Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu 
    370                 375                 380                 
Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His 
385                 390                 395                 400 
Gly Thr Phe Leu Gly Phe Val Lys 
                405             

<210> 93
<211> 407
<212> PRT
<213> Artificial Sequence


<220> 
<223> ps4186 (full Fc-APRIL)

<400> 93
Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Leu 
1               5                   10                  15      
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            20                  25                  30          
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        35                  40                  45              
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    50                  55                  60                  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
65                  70                  75                  80  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                85                  90                  95      
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            100                 105                 110         
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        115                 120                 125             
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    130                 135                 140                 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
145                 150                 155                 160 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                165                 170                 175     
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            180                 185                 190         
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        195                 200                 205             
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    210                 215                 220                 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
225                 230                 235                 240 
Pro Gly Lys Arg Ser Pro Gln Pro Gln Pro Lys Pro Gln Pro Lys Pro 
                245                 250                 255     
Glu Pro Glu Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Ser Leu 
            260                 265                 270         
Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp 
        275                 280                 285             
Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly 
    290                 295                 300                 
Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly 
305                 310                 315                 320 
Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr 
                325                 330                 335     
Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu 
            340                 345                 350         
Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn 
        355                 360                 365             
Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu 
    370                 375                 380                 
Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His 
385                 390                 395                 400 
Gly Thr Phe Leu Gly Phe Val 
                405         

<210> 94
<211> 406
<212> PRT
<213> Artificial Sequence


<220> 
<223> ps4187 (full Fc-APRIL)

<400> 94
Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Leu 
1               5                   10                  15      
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            20                  25                  30          
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        35                  40                  45              
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    50                  55                  60                  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
65                  70                  75                  80  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                85                  90                  95      
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            100                 105                 110         
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        115                 120                 125             
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    130                 135                 140                 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
145                 150                 155                 160 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                165                 170                 175     
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            180                 185                 190         
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        195                 200                 205             
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    210                 215                 220                 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
225                 230                 235                 240 
Pro Gly Lys Arg Ser Pro Gln Pro Gln Pro Lys Pro Gln Pro Lys Pro 
                245                 250                 255     
Glu Pro Glu Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Ser Leu 
            260                 265                 270         
Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp 
        275                 280                 285             
Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly 
    290                 295                 300                 
Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly 
305                 310                 315                 320 
Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr 
                325                 330                 335     
Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu 
            340                 345                 350         
Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn 
        355                 360                 365             
Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu 
    370                 375                 380                 
Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His 
385                 390                 395                 400 
Gly Thr Phe Leu Gly Phe 
                405     

<210> 95
<211> 405
<212> PRT
<213> Artificial Sequence


<220> 
<223> ps4188 (full Fc-APRIL)

<400> 95
Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Leu 
1               5                   10                  15      
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            20                  25                  30          
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        35                  40                  45              
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    50                  55                  60                  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
65                  70                  75                  80  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                85                  90                  95      
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            100                 105                 110         
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        115                 120                 125             
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    130                 135                 140                 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
145                 150                 155                 160 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                165                 170                 175     
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            180                 185                 190         
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        195                 200                 205             
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    210                 215                 220                 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
225                 230                 235                 240 
Pro Gly Lys Arg Ser Pro Gln Pro Gln Pro Lys Pro Gln Pro Lys Pro 
                245                 250                 255     
Glu Pro Glu Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Ser Leu 
            260                 265                 270         
Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp 
        275                 280                 285             
Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly 
    290                 295                 300                 
Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly 
305                 310                 315                 320 
Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr 
                325                 330                 335     
Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu 
            340                 345                 350         
Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn 
        355                 360                 365             
Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu 
    370                 375                 380                 
Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His 
385                 390                 395                 400 
Gly Thr Phe Leu Gly 
                405 

<210> 96
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<223> Epitope 5 on APRIL

<400> 96
His Leu Val Pro Ile Asn Ala 
1               5           

<210> 97
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> Epitope 5 on APRIL

<400> 97
His Leu Val Pro Val Asn Ile 
1               5           

<210> 98
<211> 6
<212> PRT
<213> Mus musculus


<220> 
<223> Epitope 1,2 on APRIL

<400> 98
Pro Val Leu Arg Arg Gly 
1               5       

<210> 99
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> tryptic peptide in the Fc part

<400> 99
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
1               5                   

<210> 100
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> tryptic C terminus APRIL

<400> 100
Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys 
1               5                   10                  

<210> 101
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> miscleaved tryptic C terminus APRIL

<400> 101
Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu 
1               5                   10                  15  

<210> 102
<211> 394
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence on Figure 23 (ps1307, Fc-APRIL, mature protein)

<400> 102
Leu Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly Lys Arg Ser Pro Gln Pro Gln Pro Lys Pro Gln Pro Lys 
225                 230                 235                 240 
Pro Glu Pro Glu Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Ser 
                245                 250                 255     
Leu Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
            260                 265                 270         
Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
        275                 280                 285             
Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
    290                 295                 300                 
Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
305                 310                 315                 320 
Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
                325                 330                 335     
Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
            340                 345                 350         
Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
        355                 360                 365             
Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
    370                 375                 380                 
His Gly Thr Phe Leu Gly Phe Val Lys Leu 
385                 390                 

