                         SEQUENCE LISTING

<110>  ISAR Bioscience
 
<120>  ANTIGENS AND ASSAYS FOR DETECTING SARS-COV-2 ANTIBODIES

<130>  PCT-17929

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  243
<212>  PRT
<213>  Unknown

<220>
<223>  RBD with N-terminal signal peptide, without C-terminal His-tag

<400>  1

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            20                  25                  30          


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
        35                  40                  45              


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    50                  55                  60                  


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
65                  70                  75                  80  


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                85                  90                  95      


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            100                 105                 110         


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        115                 120                 125             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
    130                 135                 140                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
145                 150                 155                 160 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                165                 170                 175     


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
            180                 185                 190         


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
        195                 200                 205             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    210                 215                 220                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
225                 230                 235                 240 


Val Asn Phe 
            


<210>  2
<211>  730
<212>  DNA
<213>  Unknown

<220>
<223>  Nucleotide sequence encoding SEQ ID NO: 1 without stop codon

<400>  2
atggaaacac cagctcagct gctgttcctg ctgctgctgt ggctgcctga taccaccgga       60

agagtgcagc ctaccgagtc catcgtgcgg ttccccaaca tcaccaacct gtgtcctttc      120

ggcgaggtgt tcaacgccac cagattcgcc tctgtgtacg cctggaaccg gaagcggatc      180

tctaactgcg tggccgacta ctccgtgctg tacaactccg cctccttcag caccttcaag      240

tgctacggcg tgtcccctac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      300

tccttcgtga tcagaggcga cgaagtgcgg cagatcgctc ctggacagac cggcaagatc      360

gccgactaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ttggaactcc      420

aacaacctgg actccaaagt cggcggcaac tacaattacc tgtaccggct gttccggaag      480

tccaacctga agcctttcga gcgggacatc tccaccgaga tctaccaggc tggcagcacc      540

ccttgtaatg gcgtggaagg cttcaactgc tacttcccac tgcagtccta cggcttccag      600

cctacaaacg gcgtgggcta ccagccttac agagtggtgg tgctgtcctt cgagctgctg      660

catgctcctg ctaccgtgtg cggccctaag aaatctacca acctggtcaa gaacaaatgc      720

gtgaacttcc                                                             730


<210>  3
<211>  249
<212>  PRT
<213>  Unknown

<220>
<223>  RBD with N-terminal signal peptide and with C-terminal His-tag

<400>  3

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            20                  25                  30          


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
        35                  40                  45              


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    50                  55                  60                  


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
65                  70                  75                  80  


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                85                  90                  95      


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            100                 105                 110         


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        115                 120                 125             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
    130                 135                 140                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
145                 150                 155                 160 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                165                 170                 175     


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
            180                 185                 190         


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
        195                 200                 205             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    210                 215                 220                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
225                 230                 235                 240 


Val Asn Phe His His His His His His 
                245                 


<210>  4
<211>  750
<212>  DNA
<213>  Unknown

<220>
<223>  Nucleotide sequence encoding encoding SEQ ID NO: 3 with stop 
       codon

<400>  4
atggaaacac cagctcagct gctgttcctg ctgctgctgt ggctgcctga taccaccgga       60

agagtgcagc ctaccgagtc catcgtgcgg ttccccaaca tcaccaacct gtgtcctttc      120

ggcgaggtgt tcaacgccac cagattcgcc tctgtgtacg cctggaaccg gaagcggatc      180

tctaactgcg tggccgacta ctccgtgctg tacaactccg cctccttcag caccttcaag      240

tgctacggcg tgtcccctac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      300

tccttcgtga tcagaggcga cgaagtgcgg cagatcgctc ctggacagac cggcaagatc      360

gccgactaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ttggaactcc      420

aacaacctgg actccaaagt cggcggcaac tacaattacc tgtaccggct gttccggaag      480

tccaacctga agcctttcga gcgggacatc tccaccgaga tctaccaggc tggcagcacc      540

ccttgtaatg gcgtggaagg cttcaactgc tacttcccac tgcagtccta cggcttccag      600

cctacaaacg gcgtgggcta ccagccttac agagtggtgg tgctgtcctt cgagctgctg      660

catgctcctg ctaccgtgtg cggccctaag aaatctacca acctggtcaa gaacaaatgc      720

gtgaacttcc accaccacca tcaccactga                                       750


<210>  5
<211>  441
<212>  PRT
<213>  Unknown

<220>
<223>  Nucleocapsid (NP) with N-terminal signal peptide, without 
       Strep-tag

<400>  5

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala 
            20                  25                  30          


Pro Arg Ile Thr Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln 
        35                  40                  45              


Asn Gly Glu Arg Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly 
    50                  55                  60                  


Leu Pro Asn Asn Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly 
65                  70                  75                  80  


Lys Glu Asp Leu Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr 
                85                  90                  95      


Asn Ser Ser Pro Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg 
            100                 105                 110         


Arg Ile Arg Gly Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp 
        115                 120                 125             


Tyr Phe Tyr Tyr Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly 
    130                 135                 140                 


Ala Asn Lys Asp Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn 
145                 150                 155                 160 


Thr Pro Lys Asp His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala 
                165                 170                 175     


Ile Val Leu Gln Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr 
            180                 185                 190         


Ala Glu Gly Ser Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser 
        195                 200                 205             


Arg Ser Arg Asn Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly 
    210                 215                 220                 


Thr Ser Pro Ala Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala 
225                 230                 235                 240 


Leu Leu Leu Leu Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly 
                245                 250                 255     


Lys Gly Gln Gln Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala 
            260                 265                 270         


Glu Ala Ser Lys Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr 
        275                 280                 285             


Asn Val Thr Gln Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly 
    290                 295                 300                 


Asn Phe Gly Asp Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His 
305                 310                 315                 320 


Trp Pro Gln Ile Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly 
                325                 330                 335     


Met Ser Arg Ile Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr 
            340                 345                 350         


Tyr Thr Gly Ala Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp 
        355                 360                 365             


Gln Val Ile Leu Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro 
    370                 375                 380                 


Pro Thr Glu Pro Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln 
385                 390                 395                 400 


Ala Leu Pro Gln Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro 
                405                 410                 415     


Ala Ala Asp Leu Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser 
            420                 425                 430         


Ser Ala Asp Ser Thr Gln Ala Ser Ala 
        435                 440     


<210>  6
<211>  1323
<212>  DNA
<213>  Unknown

<220>
<223>  Nucleotide sequence encoding SEQ ID NO: 5

<400>  6
atggaaacac cagctcagct gctgttcctg ctgctgctgt ggctgcctga taccaccggc       60

atgtctgata acggccctca gaaccagcgg aacgccccta gaatcacctt tggcggccct      120

tccgattcca ccggctctaa ccagaacggc gagagatccg gcgctcggtc taaacagaga      180

aggcctcagg gcctgcctaa caacaccgcc tcttggttta ccgctctgac ccagcacggc      240

aaagaggacc tgaagttccc tagaggacag ggcgtgccca tcaacaccaa ctctagccct      300

gacgaccaga tcggctacta cagacgggcc accagaagaa tcagaggcgg cgacggcaag      360

atgaaggacc tgtctcctcg gtggtacttc tactacctcg gcaccggacc agaggctgga      420

ttgccttatg gcgccaacaa ggacggcatc atctgggttg caacagaggg cgctctgaac      480

acccctaagg accacatcgg cacccggaat cctgccaaca atgccgctat tgtgctgcag      540

ctgccacagg gcacaaccct gcctaagggc ttttacgccg agggatctag aggcggctct      600

caggcctctt ccagatcctc cagccggtcc agaaactcct ctcggaattc tacccctggc      660

agctccagag gcacctctcc tgctagaatg gctggcaacg gcggagatgc tgctctggct      720

ctgctgctcc tggacagact gaaccagctg gaatccaaga tgtccggcaa gggccagcag      780

caacagggcc agacagtgac caagaagtct gccgccgagg cctccaagaa gcctagacag      840

aagagaaccg ccaccaaggc ctacaacgtg acccaggcct ttggcagaag aggcccagaa      900

cagacccagg gcaacttcgg cgatcaagag ctgatcagac agggcaccga ctacaagcac      960

tggcctcaga tcgcccagtt tgccccttct gcctctgcct tcttcggcat gtcccggatc     1020

ggcatggaag tgaccccatc tggcacctgg ctgacctata ccggcgccat caagctggac     1080

gacaaggacc ccaacttcaa ggaccaagtg atcctgctga acaagcacat cgacgcctac     1140

aagacctttc cacctaccga gcctaagaag gacaagaaga agaaggccga cgagacacag     1200

gccctgcctc agagacagaa aaagcagcag accgtgacac tgctgcctgc cgctgacctg     1260

gacgacttct ctaagcagtt gcagcagtcc atgtcctccg ccgattctac ccaggcttcc     1320

gct                                                                   1323


<210>  7
<211>  449
<212>  PRT
<213>  Unknown

<220>
<223>  Nucleocapsid (NP) with N-terminal signal peptide and C-terminal 
       Strep-tag (NP-Strep)

<400>  7

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala 
            20                  25                  30          


Pro Arg Ile Thr Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln 
        35                  40                  45              


Asn Gly Glu Arg Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly 
    50                  55                  60                  


Leu Pro Asn Asn Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly 
65                  70                  75                  80  


Lys Glu Asp Leu Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr 
                85                  90                  95      


Asn Ser Ser Pro Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg 
            100                 105                 110         


Arg Ile Arg Gly Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp 
        115                 120                 125             


Tyr Phe Tyr Tyr Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly 
    130                 135                 140                 


Ala Asn Lys Asp Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn 
145                 150                 155                 160 


Thr Pro Lys Asp His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala 
                165                 170                 175     


Ile Val Leu Gln Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr 
            180                 185                 190         


Ala Glu Gly Ser Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser 
        195                 200                 205             


Arg Ser Arg Asn Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly 
    210                 215                 220                 


Thr Ser Pro Ala Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala 
225                 230                 235                 240 


Leu Leu Leu Leu Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly 
                245                 250                 255     


Lys Gly Gln Gln Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala 
            260                 265                 270         


Glu Ala Ser Lys Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr 
        275                 280                 285             


Asn Val Thr Gln Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly 
    290                 295                 300                 


Asn Phe Gly Asp Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His 
305                 310                 315                 320 


Trp Pro Gln Ile Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly 
                325                 330                 335     


Met Ser Arg Ile Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr 
            340                 345                 350         


Tyr Thr Gly Ala Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp 
        355                 360                 365             


Gln Val Ile Leu Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro 
    370                 375                 380                 


Pro Thr Glu Pro Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln 
385                 390                 395                 400 


Ala Leu Pro Gln Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro 
                405                 410                 415     


Ala Ala Asp Leu Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser 
            420                 425                 430         


Ser Ala Asp Ser Thr Gln Ala Ser Ala Trp Ser His Pro Gln Phe Glu 
        435                 440                 445             


Lys 
    


<210>  8
<211>  1350
<212>  DNA
<213>  Unknown

<220>
<223>  Nucleotide sequence encoding SEQ ID NO: 7

<400>  8
atggaaacac cagctcagct gctgttcctg ctgctgctgt ggctgcctga taccaccggc       60

atgtctgata acggccctca gaaccagcgg aacgccccta gaatcacctt tggcggccct      120

tccgattcca ccggctctaa ccagaacggc gagagatccg gcgctcggtc taaacagaga      180

aggcctcagg gcctgcctaa caacaccgcc tcttggttta ccgctctgac ccagcacggc      240

aaagaggacc tgaagttccc tagaggacag ggcgtgccca tcaacaccaa ctctagccct      300

gacgaccaga tcggctacta cagacgggcc accagaagaa tcagaggcgg cgacggcaag      360

atgaaggacc tgtctcctcg gtggtacttc tactacctcg gcaccggacc agaggctgga      420

ttgccttatg gcgccaacaa ggacggcatc atctgggttg caacagaggg cgctctgaac      480

acccctaagg accacatcgg cacccggaat cctgccaaca atgccgctat tgtgctgcag      540

ctgccacagg gcacaaccct gcctaagggc ttttacgccg agggatctag aggcggctct      600

caggcctctt ccagatcctc cagccggtcc agaaactcct ctcggaattc tacccctggc      660

agctccagag gcacctctcc tgctagaatg gctggcaacg gcggagatgc tgctctggct      720

ctgctgctcc tggacagact gaaccagctg gaatccaaga tgtccggcaa gggccagcag      780

caacagggcc agacagtgac caagaagtct gccgccgagg cctccaagaa gcctagacag      840

aagagaaccg ccaccaaggc ctacaacgtg acccaggcct ttggcagaag aggcccagaa      900

cagacccagg gcaacttcgg cgatcaagag ctgatcagac agggcaccga ctacaagcac      960

tggcctcaga tcgcccagtt tgccccttct gcctctgcct tcttcggcat gtcccggatc     1020

ggcatggaag tgaccccatc tggcacctgg ctgacctata ccggcgccat caagctggac     1080

gacaaggacc ccaacttcaa ggaccaagtg atcctgctga acaagcacat cgacgcctac     1140

aagacctttc cacctaccga gcctaagaag gacaagaaga agaaggccga cgagacacag     1200

gccctgcctc agagacagaa aaagcagcag accgtgacac tgctgcctgc cgctgacctg     1260

gacgacttct ctaagcagtt gcagcagtcc atgtcctccg ccgattctac ccaggcttcc     1320

gcttggtccc atcctcagtt cgagaagtaa                                      1350


<210>  9
<211>  682
<212>  PRT
<213>  Unknown

<220>
<223>  Amino acid sequence of the spike protein S1 of human coronavirus 
       OC43 (OC43S1) as shown in Fig. 9.

<400>  9

Met Phe Leu Ile Leu Leu Ile Ser Leu Pro Thr Ala Phe Ala Val Ile 
1               5                   10                  15      


Gly Asp Leu Asn Cys Thr Leu Asp Pro Arg Leu Lys Gly Ser Phe Asn 
            20                  25                  30          


Asn Arg Asp Thr Gly Pro Pro Ser Ile Ser Ile Asp Thr Val Asp Val 
        35                  40                  45              


Thr Asn Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn 
    50                  55                  60                  


Thr Thr Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Asn Met Ala Leu Lys Gly Thr Asp Leu Leu Ser Thr Leu Trp Phe 
                85                  90                  95      


Lys Pro Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val 
            100                 105                 110         


Lys Asn Thr Lys Val Phe Lys Asp Gly Val Met Tyr Ser Glu Phe Pro 
        115                 120                 125             


Ala Ile Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val 
    130                 135                 140                 


Val Gln Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Val Asn Lys Leu 
145                 150                 155                 160 


Gln Gly Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr 
                165                 170                 175     


Pro His Thr Ile Cys His Pro Asn Leu Gly Asn His Phe Lys Glu Leu 
            180                 185                 190         


Trp His Tyr Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe 
        195                 200                 205             


Thr Tyr Asp Val Asn Ala Thr Tyr Leu Tyr Phe His Phe Tyr Gln Glu 
    210                 215                 220                 


Gly Gly Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Phe Val Thr Lys 
225                 230                 235                 240 


Phe Leu Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val 
                245                 250                 255     


Met Pro Leu Thr Cys Ile Arg Arg Pro Lys Asp Gly Phe Ser Leu Glu 
            260                 265                 270         


Tyr Trp Val Thr Pro Leu Thr Pro Arg Gln Tyr Leu Leu Ala Phe Asn 
        275                 280                 285             


Gln Asp Gly Ile Ile Phe Asn Ala Val Asp Cys Met Ser Asp Phe Met 
    290                 295                 300                 


Ser Glu Ile Lys Cys Lys Thr Gln Ser Ile Ala Pro Pro Thr Gly Val 
305                 310                 315                 320 


Tyr Glu Leu Asn Gly Tyr Thr Val Gln Pro Val Ala Asp Val Tyr Arg 
                325                 330                 335     


Arg Lys Pro Asp Leu Pro Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp 
            340                 345                 350         


Lys Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn 
        355                 360                 365             


Cys Asn Phe Asn Met Ser Ser Leu Met Ser Phe Ile Gln Ala Asp Ser 
    370                 375                 380                 


Phe Thr Cys Asn Asn Ile Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe 
385                 390                 395                 400 


Ser Ser Ile Thr Ile Asp Lys Phe Ala Ile Pro Asn Arg Arg Lys Val 
                405                 410                 415     


Asp Leu Gln Leu Gly Asn Leu Gly Tyr Leu Gln Ser Ser Asn Tyr Arg 
            420                 425                 430         


Ile Asp Thr Thr Ala Thr Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala 
        435                 440                 445             


Ala Asn Val Ser Val Ser Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg 
    450                 455                 460                 


Phe Gly Phe Ile Glu Asp Ser Val Phe Val Pro Gln Pro Thr Gly Val 
465                 470                 475                 480 


Phe Thr Asn His Ser Val Val Tyr Ala Gln His Cys Phe Lys Ala Pro 
                485                 490                 495     


Lys Asn Phe Cys Pro Cys Ser Ser Cys Pro Gly Lys Asn Asn Gly Ile 
            500                 505                 510         


Gly Thr Cys Pro Ala Gly Thr Asn Ser Leu Thr Cys Asp Asn Leu Cys 
        515                 520                 525             


Thr Leu Asp Pro Ile Thr Leu Lys Ala Pro Asp Thr Tyr Lys Cys Pro 
    530                 535                 540                 


Gln Ser Lys Ser Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala 
545                 550                 555                 560 


Val Lys Ser Asp Tyr Cys Gly Asn Asn Ser Cys Thr Cys Gln Pro Gln 
                565                 570                 575     


Ala Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys 
            580                 585                 590         


Asn Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn Asn Gly Leu Thr 
        595                 600                 605             


Cys Ser Thr Asp Leu Gln Lys Ala Asn Thr Glu Ile Glu Leu Gly Val 
    610                 615                 620                 


Cys Val Asn Tyr Asp Leu Tyr Gly Ile Ser Gly Gln Gly Ile Phe Val 
625                 630                 635                 640 


Glu Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp 
                645                 650                 655     


Ser Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr 
            660                 665                 670         


Phe Met Ile His His His His His His His 
        675                 680         


<210>  10
<211>  2049
<212>  DNA
<213>  Unknown

<220>
<223>  SEQ ID NO: 10: coding sequence of SEQ ID NO: 9, shown in Fig. 9.

<400>  10
atgttcctga tcctgctgat ctccctgcct accgcctttg ccgtgatcgg cgacctgaac       60

tgtaccctgg accctcggct gaagggctcc ttcaacaaca gagataccgg acctccttcc      120

atctccatcg acaccgtgga tgtgaccaat ggcctgggca cctactacgt gctggaccgg      180

gtgtacctga acaccacact gtttctgaac ggctactacc ccacctccgg ctccacctac      240

agaaacatgg ctctgaaggg caccgacctg ctgagcaccc tgtggttcaa gcctccattc      300

ctgtccgact tcatcaacgg catcttcgcc aaagtgaaga acaccaaggt gttcaaggac      360

ggcgtgatgt acagcgagtt ccccgctatc accatcggct ctaccttcgt gaacacctcc      420

tactccgtgg tggtgcagcc tcggaccatc aactctacac aggatggcgt gaacaagctg      480

cagggcctgc tggaagtgtc cgtgtgccag tacaacatgt gcgagtaccc tcacaccatc      540

tgtcacccca acctgggcaa ccacttcaaa gagctgtggc actacgacac cggcgtggtg      600

tcttgcctgt acaagcggaa cttcacctac gacgtgaacg ccacctacct gtacttccac      660

ttctaccaag aaggcggcac cttctacgcc tacttcaccg ataccggctt cgtgaccaag      720

ttcctgttca acgtgtacct cggcatggcc ctgagccact actatgtgat gcccctgacc      780

tgcatcagac ggcccaagga tggcttctcc ctggaatact gggtcacccc tctgacacct      840

cggcagtacc tgctggcctt caaccaggac ggcatcatct tcaacgccgt ggactgcatg      900

agcgacttca tgtccgagat caagtgcaag acccagtcta tcgcccctcc taccggcgtg      960

tacgagctga atggctatac cgtgcagcct gtggccgacg tgtacagaag aaagcccgac     1020

ctgcctaact gcaacatcga ggcctggctg aacgacaagt ccgtgccttc tccactgaac     1080

tgggagagaa agaccttcag caactgcaac ttcaacatgt ccagcctgat gagcttcatc     1140

caggccgaca gcttcacctg taacaacatc gacgccgcca agatctacgg catgtgcttc     1200

tccagcatca caatcgacaa gttcgctatc cccaaccggc ggaaggttga cctgcagctg     1260

ggcaatctgg gctacctgca gtcctccaac taccggatcg ataccaccgc caccagctgc     1320

cagctgtact acaatctgcc tgccgccaat gtgtctgtgt cccggttcaa cccttccacc     1380

tggaacaaga gattcggctt catcgaggac tccgtgttcg tgcctcagcc tactggcgtg     1440

ttcaccaacc actctgtggt gtacgcccag cactgcttca aggcccctaa gaacttctgc     1500

ccctgctcta gctgccccgg caagaacaat ggcatcggca catgtcctgc cggcaccaac     1560

agcctgacct gtgacaacct gtgcacactg gaccccatca cactgaaggc ccctgacacc     1620

tacaagtgcc ctcagtccaa gagcctcgtc ggcatcggag agcactgttc tggactggcc     1680

gtgaagtctg actactgcgg caacaactcc tgcacctgtc agccccaagc ctttcttggc     1740

tggagcgccg actcttgcct gcaaggcgac aagtgcaaca tctttgccaa cttcatcctg     1800

cacgatgtga acaacggact gacctgctcc accgatctgc agaaggccaa caccgagatc     1860

gagctgggcg tgtgcgtgaa ctacgacctg tatggcatct ccggccaggg catctttgtg     1920

gaagtgaatg ctacctacta caactcttgg cagaacctgc tctacgactc caacggcaac     1980

ctgtacggct tccgggacta catcaccaac cggaccttca tgatccacca ccatcaccat     2040

catcactga                                                             2049


<210>  11
<211>  756
<212>  PRT
<213>  Unknown

<220>
<223>  SEQ ID NO: 11: amino acid sequence of the spike protein S1 of 
       human coronavirus HKU1 (HKU1S1) as shown in Fig. 10.

<400>  11

Met Phe Leu Ile Ile Phe Ile Leu Pro Thr Thr Leu Ala Val Ile Gly 
1               5                   10                  15      


Asp Phe Asn Cys Thr Asn Ser Phe Ile Asn Asp Tyr Asn Lys Thr Ile 
            20                  25                  30          


Pro Arg Ile Ser Glu Asp Val Val Asp Val Ser Leu Gly Leu Gly Thr 
        35                  40                  45              


Tyr Tyr Val Leu Asn Arg Val Tyr Leu Asn Thr Thr Leu Leu Phe Thr 
    50                  55                  60                  


Gly Tyr Phe Pro Lys Ser Gly Ala Asn Phe Arg Asp Leu Ala Leu Lys 
65                  70                  75                  80  


Gly Ser Lys Tyr Leu Ser Thr Leu Trp Tyr Lys Pro Pro Phe Leu Ser 
                85                  90                  95      


Asp Phe Asn Asn Gly Ile Phe Ser Lys Val Lys Asn Thr Lys Leu Tyr 
            100                 105                 110         


Val Asn Asn Thr Leu Tyr Ser Glu Phe Ser Thr Ile Val Ile Gly Ser 
        115                 120                 125             


Val Phe Val Asn Thr Ser Tyr Thr Ile Val Val Gln Pro His Asn Gly 
    130                 135                 140                 


Ile Leu Glu Ile Thr Ala Cys Gln Tyr Thr Met Cys Glu Tyr Pro His 
145                 150                 155                 160 


Thr Val Cys Lys Ser Lys Gly Ser Ile Arg Asn Glu Ser Trp His Ile 
                165                 170                 175     


Asp Ser Ser Glu Pro Leu Cys Leu Phe Lys Lys Asn Phe Thr Tyr Asn 
            180                 185                 190         


Val Ser Ala Asp Trp Leu Tyr Phe His Phe Tyr Gln Glu Arg Gly Val 
        195                 200                 205             


Phe Tyr Ala Tyr Tyr Ala Asp Val Gly Met Pro Thr Thr Phe Leu Phe 
    210                 215                 220                 


Ser Leu Tyr Leu Gly Thr Ile Leu Ser His Tyr Tyr Val Met Pro Leu 
225                 230                 235                 240 


Thr Cys Lys Ala Ile Ser Ser Asn Thr Asp Asn Glu Thr Leu Glu Tyr 
                245                 250                 255     


Trp Val Thr Pro Leu Ser Arg Arg Gln Tyr Leu Leu Asn Phe Asp Glu 
            260                 265                 270         


His Gly Val Ile Thr Asn Ala Val Asp Cys Ser Ser Ser Phe Leu Ser 
        275                 280                 285             


Glu Ile Gln Cys Lys Thr Gln Ser Phe Ala Pro Asn Thr Gly Val Tyr 
    290                 295                 300                 


Asp Leu Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val Tyr Arg Arg 
305                 310                 315                 320 


Ile Pro Asn Leu Pro Asp Cys Asp Ile Asp Asn Trp Leu Asn Asn Val 
                325                 330                 335     


Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Arg Ile Phe Ser Asn Cys 
            340                 345                 350         


Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Val Asp Ser Phe 
        355                 360                 365             


Ser Cys Asn Asn Leu Asp Lys Ser Lys Ile Phe Gly Ser Cys Phe Asn 
    370                 375                 380                 


Ser Ile Thr Val Asp Lys Phe Ala Ile Pro Asn Arg Arg Arg Asp Asp 
385                 390                 395                 400 


Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn Tyr Lys Ile 
                405                 410                 415     


Asp Ile Ser Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu Pro Leu Val 
            420                 425                 430         


Asn Val Thr Ile Asn Asn Phe Asn Pro Ser Ser Trp Asn Arg Arg Tyr 
        435                 440                 445             


Gly Phe Gly Ser Phe Asn Val Ser Ser Tyr Asp Val Val Tyr Ser Asp 
    450                 455                 460                 


His Cys Phe Ser Val Asn Ser Asp Phe Cys Pro Cys Ala Asp Pro Ser 
465                 470                 475                 480 


Val Val Asn Ser Cys Val Lys Ser Lys Pro Leu Ser Ala Ile Cys Pro 
                485                 490                 495     


Ala Gly Thr Lys Tyr Arg His Cys Asp Leu Asp Thr Thr Leu Tyr Val 
            500                 505                 510         


Asn Asn Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile Ser Thr Tyr 
        515                 520                 525             


Ser Pro Asn Thr Cys Pro Gln Lys Lys Val Val Val Gly Ile Gly Glu 
    530                 535                 540                 


His Cys Pro Gly Leu Gly Ile Asn Glu Glu Lys Cys Gly Thr Gln Leu 
545                 550                 555                 560 


Asn His Ser Ser Cys Ser Cys Ser Pro Asp Ala Phe Leu Gly Trp Ser 
                565                 570                 575     


Phe Asp Ser Cys Ile Ser Asn Asn Arg Cys Asn Ile Phe Ser Asn Phe 
            580                 585                 590         


Ile Phe Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Asn Asp Leu Leu 
        595                 600                 605             


Tyr Ser Asn Thr Glu Val Ser Thr Gly Val Cys Val Asn Tyr Asp Leu 
    610                 615                 620                 


Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Ser Ala Ala Tyr 
625                 630                 635                 640 


Tyr Asn Asn Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn Ile Ile 
                645                 650                 655     


Gly Phe Lys Asp Phe Leu Thr Asn Lys Thr Tyr Thr Ile Leu Pro Cys 
            660                 665                 670         


Tyr Ser Gly Arg Val Ser Ala Ala Phe Tyr Gln Asn Ser Ser Ser Pro 
        675                 680                 685             


Ala Leu Leu Tyr Arg Asn Leu Lys Cys Ser Tyr Val Leu Asn Asn Ile 
    690                 695                 700                 


Ser Phe Ile Ser Gln Pro Phe Tyr Phe Asp Ser Tyr Leu Gly Cys Val 
705                 710                 715                 720 


Leu Asn Ala Val Asn Leu Thr Ser Tyr Ser Val Ser Ser Cys Asp Leu 
                725                 730                 735     


Arg Met Gly Ser Gly Phe Cys Ile Asp Tyr Ala Leu Pro Ser His His 
            740                 745                 750         


His His His His 
        755     


<210>  12
<211>  2271
<212>  DNA
<213>  Unknown

<220>
<223>  SEQ ID NO: 12: coding sequence of SEQ ID NO: 11, shown in Fig. 10

<400>  12
atgttcctga tcatcttcat cctgcctacc acactggccg tgatcggcga cttcaactgc       60

accaacagct tcatcaacga ctacaacaag acaatccctc ggatctccga ggacgtggtg      120

gatgtgtctc ttggcctggg cacctactac gtgctgaacc gggtgtacct gaacaccaca      180

ctgctgttca ccggctactt ccctaagtcc ggcgccaact tcagagatct ggccctgaag      240

ggctccaagt acctgagcac cctgtggtac aagcctccat tcctgtctga cttcaacaac      300

ggcatcttct ccaaagtgaa gaacaccaag ctgtacgtga acaacaccct gtactccgag      360

ttctccacca tcgtgatcgg ctccgtgttc gtgaacacct cctataccat cgtggtgcag      420

ccccacaatg gcatcctgga aatcaccgcc tgccagtaca ccatgtgcga gtaccctcac      480

accgtgtgca agtccaaggg cagcatccgg aacgagtcct ggcacatcga ttcctccgag      540

cctctgtgcc tgttcaagaa gaacttcacc tacaacgtgt ccgccgactg gctgtacttc      600

cacttctatc aagagcgggg cgtgttctac gcctactacg ctgatgtggg aatgccaacc      660

accttcctgt tctccctgta tctgggcacc atcctgagcc actactatgt gatgcccctg      720

acctgcaagg ccatctcctc caacaccgac aacgagacac tggaatactg ggtcacccct      780

ctgtctcgga ggcagtacct gctgaacttc gatgagcacg gcgtgatcac caacgccgtg      840

gactgttcct ccagcttcct gtccgagatc cagtgcaaga cccagagctt cgcccctaac      900

accggcgtgt acgatctgtc tggctttacc gtgaagcccg tggccaccgt gtaccggcga      960

attcctaacc tgcctgactg cgacatcgac aactggctga acaatgtgtc cgtgccttct     1020

ccactgaact gggagagaag aatcttcagc aactgcaact tcaacctgtc taccctgctg     1080

cggctggtgc acgtggacag cttctcttgc aacaacctgg acaagagcaa gatcttcggc     1140

tcctgcttca actccatcac cgtggacaag ttcgctatcc ccaacagaag gcgggacgat     1200

ctgcagctgg gctcctctgg cttcctgcag tcctccaact acaagatcga tatctccagc     1260

tcctcctgcc agctgtacta ctccctgcct ctggtcaacg tgaccatcaa caacttcaat     1320

ccctccagtt ggaatcggag atacggcttc ggcagcttta acgtgtcctc ctacgacgtg     1380

gtgtacagcg accactgctt ctccgtgaac tccgacttct gcccttgcgc cgatccttcc     1440

gtggtcaact cctgcgtgaa gtccaagcct ctgtccgcca tttgtcctgc cggcaccaag     1500

tacagacact gcgacctgga cacaaccctg tatgtcaaca actggtgccg gtgctcctgc     1560

ctgcctgatc ctatctctac ctactctccc aacacctgtc ctcagaaaaa ggtggtcgtc     1620

ggcatcggcg agcattgtcc tggcctggga atcaacgagg aaaagtgcgg cacccagctg     1680

aaccactcca gctgctcttg tagccctgat gccttcctcg gctggtcctt cgactcctgc     1740

atctccaaca accggtgcaa catcttctct aacttcatct tcaacgggat caactccggc     1800

accacctgtt ccaacgacct gctgtactct aacaccgagg tgtccacagg cgtgtgcgtg     1860

aactacgacc tgtatggcat caccggccag ggcatcttca aagaggtgtc cgctgcctac     1920

tataacaact ggcagaatct gctgtacgac tccaacggca acattatcgg cttcaaggac     1980

ttcctgacca acaagaccta caccattctg ccctgctact ctggcagagt gtctgccgcc     2040

ttctaccaga actcctcctc tcctgctctg ctgtatcgga acctgaagtg ctcctatgtg     2100

ctgaacaaca tcagctttat ctcccagcct ttctacttcg acagctacct gggctgcgtg     2160

ctgaatgccg tgaacctgac ctcctactcc gtgtcctctt gcgacctgag aatgggctcc     2220

ggcttctgca tcgattacgc cctgcctagc caccaccacc atcaccatta a              2271


<210>  13
<211>  723
<212>  PRT
<213>  Unknown

<220>
<223>  SEQ ID NO: 13: amino acid sequence of the spike protein S1 of 
       human coronavirus NL63 (NL63S1) as shown in Fig. 11.

<400>  13

Met Lys Leu Phe Leu Ile Leu Leu Val Leu Pro Leu Ala Ser Cys Phe 
1               5                   10                  15      


Phe Thr Cys Asn Ser Asn Ala Asn Leu Ser Met Leu Gln Leu Gly Val 
            20                  25                  30          


Pro Asp Asn Ser Ser Thr Ile Val Thr Gly Leu Leu Pro Thr His Trp 
        35                  40                  45              


Phe Cys Ala Asn Gln Ser Thr Ser Val Tyr Ser Ala Asn Gly Phe Phe 
    50                  55                  60                  


Tyr Ile Asp Val Gly Asn His Arg Ser Ala Phe Ala Leu His Thr Gly 
65                  70                  75                  80  


Tyr Tyr Asp Val Asn Gln Tyr Tyr Ile Tyr Val Thr Asn Glu Ile Gly 
                85                  90                  95      


Leu Asn Ala Ser Val Thr Leu Lys Ile Cys Lys Phe Gly Ile Asn Thr 
            100                 105                 110         


Thr Phe Asp Phe Leu Ser Asn Ser Ser Ser Ser Phe Asp Cys Ile Val 
        115                 120                 125             


Asn Leu Leu Phe Thr Glu Gln Leu Gly Ala Pro Leu Gly Ile Thr Ile 
    130                 135                 140                 


Ser Gly Glu Thr Val Arg Leu His Leu Tyr Asn Val Thr Arg Thr Phe 
145                 150                 155                 160 


Tyr Val Pro Ala Ala Tyr Lys Leu Thr Lys Leu Ser Val Lys Cys Tyr 
                165                 170                 175     


Phe Asn Tyr Ser Cys Val Phe Ser Val Val Asn Ala Thr Val Thr Val 
            180                 185                 190         


Asn Val Thr Thr His Asn Gly Arg Val Val Asn Tyr Thr Val Cys Asp 
        195                 200                 205             


Asp Cys Asn Gly Tyr Thr Asp Asn Ile Phe Ser Val Gln Gln Asp Gly 
    210                 215                 220                 


Arg Ile Pro Asn Gly Phe Pro Phe Asn Asn Trp Phe Leu Leu Thr Asn 
225                 230                 235                 240 


Gly Ser Thr Leu Val Asp Gly Val Ser Arg Leu Tyr Gln Pro Leu Arg 
                245                 250                 255     


Leu Thr Cys Leu Trp Pro Val Pro Gly Leu Lys Ser Ser Thr Gly Phe 
            260                 265                 270         


Val Tyr Phe Asn Ala Thr Gly Ser Asp Val Asn Cys Asn Gly Tyr Gln 
        275                 280                 285             


His Asn Ser Val Ala Asp Val Met Arg Tyr Asn Leu Asn Phe Ser Ala 
    290                 295                 300                 


Asn Ser Val Asp Asn Leu Lys Ser Gly Val Ile Val Phe Lys Thr Leu 
305                 310                 315                 320 


Gln Tyr Asp Val Leu Phe Tyr Cys Ser Asn Ser Ser Ser Gly Val Leu 
                325                 330                 335     


Asp Thr Thr Ile Pro Phe Gly Pro Ser Ser Gln Pro Tyr Tyr Cys Phe 
            340                 345                 350         


Ile Asn Ser Thr Ile Asn Thr Thr His Val Ser Thr Phe Val Gly Ile 
        355                 360                 365             


Leu Pro Pro Thr Val Arg Glu Ile Val Val Ala Arg Thr Gly Gln Phe 
    370                 375                 380                 


Tyr Ile Asn Gly Phe Lys Tyr Phe Asp Leu Gly Phe Ile Glu Ala Val 
385                 390                 395                 400 


Asn Phe Asn Val Thr Thr Ala Ser Ala Thr Asp Phe Trp Thr Val Ala 
                405                 410                 415     


Phe Ala Thr Phe Val Asp Val Leu Val Asn Val Ser Ala Thr Lys Ile 
            420                 425                 430         


Gln Asn Leu Leu Tyr Cys Asp Ser Pro Phe Glu Lys Leu Gln Cys Glu 
        435                 440                 445             


His Leu Gln Phe Gly Leu Gln Asp Gly Phe Tyr Ser Ala Asn Phe Leu 
    450                 455                 460                 


Asp Asp Asn Val Leu Pro Glu Thr Tyr Val Ala Leu Pro Ile Tyr Tyr 
465                 470                 475                 480 


Gln His Thr Asp Ile Asn Phe Thr Ala Thr Ala Ser Phe Gly Gly Ser 
                485                 490                 495     


Cys Tyr Val Cys Lys Pro His Gln Val Asn Ile Ser Leu Asn Gly Asn 
            500                 505                 510         


Thr Ser Val Cys Val Arg Thr Ser His Phe Ser Ile Arg Tyr Ile Tyr 
        515                 520                 525             


Asn Arg Val Lys Ser Gly Ser Pro Gly Asp Ser Ser Trp His Ile Tyr 
    530                 535                 540                 


Leu Lys Ser Gly Thr Cys Pro Phe Ser Phe Ser Lys Leu Asn Asn Phe 
545                 550                 555                 560 


Gln Lys Phe Lys Thr Ile Cys Phe Ser Thr Val Glu Val Pro Gly Ser 
                565                 570                 575     


Cys Asn Phe Pro Leu Glu Ala Thr Trp His Tyr Thr Ser Tyr Thr Ile 
            580                 585                 590         


Val Gly Ala Leu Tyr Val Thr Trp Ser Glu Gly Asn Ser Ile Thr Gly 
        595                 600                 605             


Val Pro Tyr Pro Val Ser Gly Ile Arg Glu Phe Ser Asn Leu Val Leu 
    610                 615                 620                 


Asn Asn Cys Thr Lys Tyr Asn Ile Tyr Asp Tyr Val Gly Thr Gly Ile 
625                 630                 635                 640 


Ile Arg Ser Ser Asn Gln Ser Leu Ala Gly Gly Ile Thr Tyr Val Ser 
                645                 650                 655     


Asn Ser Gly Asn Leu Leu Gly Phe Lys Asn Val Ser Thr Gly Asn Ile 
            660                 665                 670         


Phe Ile Val Thr Pro Cys Asn Gln Pro Asp Gln Val Ala Val Tyr Gln 
        675                 680                 685             


Gln Ser Ile Ile Gly Ala Met Thr Ala Val Asn Glu Ser Arg Tyr Gly 
    690                 695                 700                 


Leu Gln Asn Leu Leu Gln Leu Pro Asn Phe Tyr Tyr Val His His His 
705                 710                 715                 720 


His His His 
            


<210>  14
<211>  2172
<212>  DNA
<213>  Unknown

<220>
<223>  SEQ ID NO: 14: coding sequence of SEQ ID NO: 13, shown in Fig. 
       11.

<400>  14
atgaagctgt tcctgatcct gctggtgctg cctctggcct cctgcttctt cacctgtaac       60

tccaacgcca acctgtccat gctgcagctg ggcgtgcccg acaactcttc taccatcgtg      120

acaggcctgc tgcctacaca ctggttctgc gccaaccaga gcacctccgt gtactctgcc      180

aacggcttct tctacatcga cgtgggcaac cacagatccg ccttcgctct gcacaccggc      240

tactacgacg tgaaccagta ctacatctac gtgaccaacg agatcggcct gaacgccagc      300

gtgaccctga agatctgcaa gttcggcatc aataccacct tcgactttct gtccaactcc      360

tcctcctctt tcgactgcat cgtgaacctg ctgttcaccg agcagctggg agcccctctg      420

ggcatcacaa tttctggcga aaccgtgcgg ctgcacctgt acaacgtgac cagaaccttc      480

tacgtgccag ccgcctacaa gctgaccaag ctgtccgtga agtgctactt caactactcc      540

tgcgtgttct ccgtggtcaa tgccaccgtg accgtgaacg tgacaaccca caatggccgg      600

gtcgtgaact acaccgtgtg cgacgactgt aacggctaca ccgataacat cttctccgtg      660

cagcaggacg gcagaatccc taacggcttc cccttcaaca actggttcct gctgaccaac      720

ggcagcaccc tggttgatgg cgtgtccaga ctgtaccagc ctctgagact gacctgcctg      780

tggcctgtgc caggactgaa atcctctacc ggcttcgtgt acttcaacgc caccggctcc      840

gatgtgaact gcaatggcta ccagcacaac tccgtggccg acgtgatgcg gtacaacctg      900

aacttctccg ccaacagcgt ggacaatctg aagtccggcg tgatcgtgtt caagaccctg      960

cagtacgacg tgctgttcta ctgctccaac tccagctctg gcgtgctgga cacaacaatc     1020

cctttcggcc cttccagcca gccttactac tgcttcatca actccaccat caacaccaca     1080

cacgtgtcca ccttcgtggg catcctgcct ccaacagtgc gggaaatcgt ggtggctaga     1140

accggccagt tttacatcaa cgggttcaag tacttcgacc tgggcttcat cgaggccgtg     1200

aacttcaatg tgaccaccgc ctccgccacc gatttttgga ccgtggcctt tgccaccttt     1260

gtggacgtgc tggtcaatgt gtccgccacc aagatccaga atctgctgta ctgcgacagc     1320

cccttcgaga agctgcagtg cgagcatctg cagtttggcc tgcaagacgg cttctacagc     1380

gccaacttcc tggacgacaa cgtgctgccc gagacatatg tggccctgcc tatctactac     1440

cagcataccg acatcaactt taccgccacc gcttccttcg gcggctcttg ctacgtgtgc     1500

aagccccacc aagtgaacat ctccctgaac ggcaacacca gcgtgtgcgt gcggacctct     1560

cacttctcca tccggtacat ctacaaccgc gtgaagtctg gctcccctgg cgactcttct     1620

tggcacatct acctgaaatc cgggacctgt cctttcagct tctccaagct gaacaacttc     1680

cagaagttta agaccatctg cttctccacc gtggaagtgc ccggctcctg taactttcca     1740

ctggaagcca cctggcacta caccagctac acaatcgtgg gcgccctgta tgtgacttgg     1800

agcgagggca attccatcac cggcgtgccc tatcctgtgt ccggcatccg cgagttctct     1860

aacctggtgc tgaacaattg caccaagtac aatatctacg actacgtcgg caccggcatc     1920

atccggtcct ctaaccagtc tctggctggc ggcatcacct acgtgtccaa ttctggcaac     1980

ctgctgggct ttaagaatgt gtccaccggc aacatcttca tcgtgacccc ttgcaaccag     2040

cctgaccagg tggcagtgta ccagcagtct atcatcggcg ccatgaccgc cgtgaacgag     2100

tctagatacg gcctgcagaa cctgctccag ctgcctaact tctactacgt gcaccaccac     2160

catcaccact ga                                                         2172


<210>  15
<211>  543
<212>  PRT
<213>  Unknown

<220>
<223>  SEQ ID NO: 15: amino acid sequence of the spike protein S1 of 
       human coronavirus 229E (229ES1) as shown in Fig. 12

<400>  15

Met Phe Val Leu Leu Val Ala Tyr Ala Leu Leu His Ile Ala Gly Cys 
1               5                   10                  15      


Gln Thr Thr Asn Gly Thr Asn Thr Ser His Ser Val Cys Asn Gly Cys 
            20                  25                  30          


Val Gly His Ser Glu Asn Val Phe Ala Val Glu Ser Gly Gly Tyr Ile 
        35                  40                  45              


Pro Ser Asn Phe Ala Phe Asn Asn Trp Phe Leu Leu Thr Asn Thr Ser 
    50                  55                  60                  


Ser Val Val Asp Gly Val Val Arg Ser Phe Gln Pro Leu Leu Leu Asn 
65                  70                  75                  80  


Cys Leu Trp Ser Val Tyr Gly Ser Glu Phe Thr Thr Gly Phe Val Tyr 
                85                  90                  95      


Phe Asn Gly Asn Gly Arg Gly Ala Cys Lys Gly Phe Tyr Ser Asn Ala 
            100                 105                 110         


Ser Ser Asp Val Ile Arg Tyr Asn Ile Asn Phe Glu Glu Asn Leu Arg 
        115                 120                 125             


Arg Gly Thr Ile Leu Phe Lys Thr Ser Tyr Gly Ala Val Val Phe Tyr 
    130                 135                 140                 


Cys Thr Asn Asn Thr Leu Val Ser Gly Asp Ala His Ile Pro Ser Gly 
145                 150                 155                 160 


Thr Val Leu Gly Asn Phe Tyr Cys Phe Val Asn Thr Thr Ile Gly Asn 
                165                 170                 175     


Glu Thr Thr Ser Ala Phe Val Gly Ala Leu Pro Lys Thr Val Arg Glu 
            180                 185                 190         


Phe Val Ile Ser Arg Thr Gly His Phe Tyr Ile Asn Gly Tyr Arg Tyr 
        195                 200                 205             


Phe Ser Leu Gly Asn Val Glu Ala Val Asn Phe Asn Val Thr Asn Ala 
    210                 215                 220                 


Ala Thr Thr Val Cys Thr Val Ala Leu Ala Ser Tyr Ala Asp Val Leu 
225                 230                 235                 240 


Val Asn Val Ser Gln Thr Ala Ile Ala Asn Ile Ile Tyr Cys Asn Ser 
                245                 250                 255     


Val Ile Asn Arg Leu Arg Cys Asp Gln Leu Ser Phe Asp Val Pro Asp 
            260                 265                 270         


Gly Phe Tyr Ser Thr Ser Pro Ile Gln Pro Val Glu Leu Pro Val Ser 
        275                 280                 285             


Ile Val Ser Leu Pro Val Tyr His Lys His Thr Phe Ile Val Leu Tyr 
    290                 295                 300                 


Val Asn Phe Glu His Gln Arg Gly Pro Gly Lys Cys Tyr Asn Cys Arg 
305                 310                 315                 320 


Pro Ala Val Ile Asn Ile Thr Leu Ala Asn Phe Asn Glu Thr Lys Gly 
                325                 330                 335     


Pro Leu Cys Val Asp Thr Ser His Phe Thr Thr Gln Phe Val Asp Asn 
            340                 345                 350         


Val Lys Leu Ala Arg Trp Ser Ala Ser Ile Asn Thr Gly Asn Cys Pro 
        355                 360                 365             


Phe Ser Phe Gly Lys Val Ile Asn Phe Val Lys Phe Gly Ser Val Cys 
    370                 375                 380                 


Phe Ser Leu Lys Tyr Ile Pro Gly Gly Cys Ala Met Pro Ile Met Ala 
385                 390                 395                 400 


Asn Leu Val Asn His Lys Ser His Asn Ile Gly Ser Leu Tyr Val Ser 
                405                 410                 415     


Trp Ser Asp Gly Asp Val Ile Thr Gly Val Pro Lys Pro Val Glu Gly 
            420                 425                 430         


Val Ser Ser Phe Met Asn Val Thr Leu Asn Lys Cys Thr Lys Tyr Asn 
        435                 440                 445             


Ile Tyr Asp Val Ser Gly Val Gly Val Ile Arg Ile Ser Asn Asp Thr 
    450                 455                 460                 


Phe Leu Asn Gly Ile Thr Tyr Thr Ser Thr Ser Gly Asn Leu Leu Gly 
465                 470                 475                 480 


Phe Lys Asp Val Thr Asn Gly Thr Ile Tyr Ser Ile Thr Pro Cys Asn 
                485                 490                 495     


Pro Pro Asp Gln Leu Val Val Tyr Gln Gln Ala Val Val Gly Ala Met 
            500                 505                 510         


Leu Ser Glu Asn Phe Thr Ser Tyr Gly Phe Ser Asn Val Val Glu Met 
        515                 520                 525             


Pro Lys Phe Phe Tyr Ala Ser Asn Gly His His His His His His 
    530                 535                 540             


<210>  16
<211>  1632
<212>  DNA
<213>  Unknown

<220>
<223>  SEQ ID NO: 16: coding sequence of SEQ ID NO: 15, shown in Fig. 
       12.

<400>  16
atgttcgtgc tgctggtggc ttacgccctg ctgcatattg ctggctgcca gaccaccaac       60

ggcaccaaca cctctcactc tgtgtgcaac ggctgcgtgg gccactctga gaatgtgttc      120

gctgtggaat ccggcggcta catcccttcc aacttcgcct tcaacaactg gttcctgctg      180

accaacacca gctccgtggt ggatggcgtc gtgcggtctt ttcagcctct gctgctgaac      240

tgcctttgga gcgtgtacgg ctccgagttc accaccggct tcgtgtactt caacggcaat      300

ggcagaggcg cctgcaaggg cttctactcc aacgcctctt ctgacgtgat ccggtacaac      360

atcaacttcg aggaaaacct gcggagaggc acaatcctgt tcaagacctc ctacggcgct      420

gtggtgttct actgcaccaa caacaccctg gtgtccggcg acgctcatat cccatctgga      480

accgtgctgg gcaacttcta ctgcttcgtg aacaccacca tcggcaacga gacaacctct      540

gcctttgtgg gcgctctgcc taagaccgtg cgcgagttcg tgatctctag aaccggccac      600

ttctacatca acggctaccg gtacttctcc ctgggcaacg tggaagccgt gaacttcaat      660

gtgaccaacg ccgccaccac cgtgtgtaca gttgccctgg cttcttacgc cgacgtgctg      720

gtcaatgtgt cccagaccgc tatcgccaac atcatctact gcaactccgt gatcaaccgg      780

ctgagatgcg accagctgtc tttcgatgtg cccgacggct tctacagcac ctctcctatc      840

cagcctgtgg aactgcccgt gtccatcgtg tctctgcctg tgtaccacaa gcacaccttc      900

atcgtgctgt acgtgaactt tgagcaccag cgcggacccg gcaagtgcta caactgtaga      960

cccgctgtga tcaatatcac cctggccaac ttcaacgaga ctaagggccc tctgtgcgtg     1020

gacaccagcc acttcaccac acagttcgtg gacaacgtga agctggctcg ttggagcgcc     1080

tctatcaaca ccggcaactg ccctttcagc ttcggcaaag tgatcaattt cgtgaagttc     1140

ggctccgtgt gcttcagcct gaagtacatc cctggcggct gcgccatgcc tatcatggcc     1200

aatctggtca accacaagtc ccacaacatc ggctccctgt atgtgtcttg gagcgacggc     1260

gacgtgatca caggcgtgcc aaaacctgtg gaaggcgtgt cctccttcat gaacgtgacc     1320

ctgaacaagt gcaccaagta caatatctac gatgtgtctg gcgtgggcgt gatcagaatc     1380

tccaacgaca ccttcctgaa cggcatcacc tacacctcca cctccggcaa cctgctgggc     1440

ttcaaggatg tgacaaatgg caccatctac agcatcaccc cttgcaaccc tccagatcag     1500

ctggtggtgt accagcaggc agtcgtggga gctatgctgt ccgagaactt caccagctac     1560

ggcttctcca acgtggtgga aatgcccaag ttcttctacg cctccaacgg ccatcaccat     1620

caccaccact aa                                                         1632


<210>  17
<211>  594
<212>  PRT
<213>  Unknown

<220>
<223>  SEQ ID NO: 17: amino acid sequence of SARS-CoV-2 spike SII as 
       shown in Fig. 13.

<400>  17

Met Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
1               5                   10                  15      


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
            20                  25                  30          


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
        35                  40                  45              


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
    50                  55                  60                  


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
65                  70                  75                  80  


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
                85                  90                  95      


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
            100                 105                 110         


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
        115                 120                 125             


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
    130                 135                 140                 


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
145                 150                 155                 160 


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
                165                 170                 175     


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
            180                 185                 190         


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
        195                 200                 205             


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
    210                 215                 220                 


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
225                 230                 235                 240 


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
                245                 250                 255     


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
            260                 265                 270         


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
        275                 280                 285             


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala 
    290                 295                 300                 


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
305                 310                 315                 320 


Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser 
                325                 330                 335     


Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser 
            340                 345                 350         


Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 
        355                 360                 365             


Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro 
    370                 375                 380                 


Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly 
385                 390                 395                 400 


Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His 
                405                 410                 415     


Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr 
            420                 425                 430         


Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val 
        435                 440                 445             


Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys 
    450                 455                 460                 


Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp 
465                 470                 475                 480 


Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys 
                485                 490                 495     


Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu 
            500                 505                 510         


Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro 
        515                 520                 525             


Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
    530                 535                 540                 


Val Thr Ile Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys 
545                 550                 555                 560 


Gly Cys Cys Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser 
                565                 570                 575     


Glu Pro Val Leu Lys Gly Val Lys Leu His Tyr Thr His His His His 
            580                 585                 590         


His His 
        


<210>  18
<211>  1785
<212>  DNA
<213>  Unknown

<220>
<223>  SEQ ID NO: 18: coding sequence of SEQ ID NO: 17, shown in Fig. 
       13.

<400>  18
atggtggcca gccagtccat cattgcctac accatgtctc tgggcgccga gaactctgtg       60

gcctactcca acaactctat cgctatcccc accaacttca ccatctccgt gaccaccgag      120

atcctgcctg tgtccatgac caagacctcc gtggactgca ccatgtacat ctgcggcgac      180

tccaccgagt gctccaatct gctgctgcag tacggctcct tctgcaccca gctgaataga      240

gccctgaccg gaatcgccgt ggaacaggac aagaacaccc aagaggtgtt cgcccaagtg      300

aagcagatct acaagacccc tcctatcaag gacttcggcg gcttcaactt ctcccagatt      360

ctgcccgatc cttccaagcc tagcaagcgg tccttcatcg aggacctgct gttcaacaaa      420

gtgaccctgg ccgacgccgg cttcatcaag cagtatggcg attgcctggg cgacattgcc      480

gccagggatc tgatctgtgc ccagaagttt aacggcctga ccgtgctgcc tcctctgctg      540

accgatgaga tgatcgccca gtacacctct gctctgctgg ccggcacaat cacctctggc      600

tggacatttg gagctggcgc cgctctgcag atcccattcg ctatgcagat ggcctaccgg      660

ttcaacggca tcggcgtgac ccagaacgtg ctgtacgaga accagaagct gatcgccaac      720

cagttcaact ccgccatcgg caagatccag gactccctgt cctctaccgc ttctgctctg      780

ggcaagctgc aggacgtggt caaccagaat gcccaggctc tgaacaccct ggtcaagcag      840

ctgtcctcca acttcggcgc catctcctct gtgctgaacg acatcctgag ccggctggac      900

aaggtggaag ccgaggtgca gatcgacaga ctgatcaccg gacggctgca gtccctgcag      960

acctatgtta cccagcagct gatcagagcc gccgagatca gggcctctgc taatctggct     1020

gctaccaaga tgtccgagtg cgtgctgggc cagtccaaga gagtggattt ttgcggcaag     1080

ggctaccacc tgatgagctt ccctcagtct gctcctcacg gcgtggtgtt tctgcacgtg     1140

acctacgtgc ccgctcaaga gaagaacttt accaccgctc ctgccatctg ccacgacggc     1200

aaggctcact ttcctcgaga aggcgtgttc gtgtccaacg gcacccattg gttcgtgaca     1260

cagcggaact tctacgagcc ccagatcatc accaccgaca acaccttcgt gtccggcaac     1320

tgcgacgtcg tgatcggcat cgtgaacaat accgtgtacg accctctgca gcccgagctg     1380

gactccttca aagaggaact ggacaagtac ttcaagaacc acacctctcc agacgtggac     1440

ctgggcgata tcagcggcat caatgcctcc gtcgtgaaca tccagaaaga gatcgaccgg     1500

ctgaacgagg tggccaagaa cctgaacgag tccctgatcg acctgcaaga gctggggaag     1560

tacgagcagt acatcaagtg gccctggtac atctggctgg gctttatcgc tggcctgatc     1620

gctatcgtga tggtcacaat catgctgtgc tgtatgacct cctgctgctc ctgcctgaag     1680

ggctgctgtt cttgcggctc ttgctgcaag ttcgacgagg acgactctga gccagtgctg     1740

aagggcgtga agctgcacta cacccaccac caccatcacc actga                     1785


<210>  19
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  SEQ ID NO: 19: signal peptide

<400>  19

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  20
<211>  249
<212>  PRT
<213>  Unknown

<220>
<223>  SEQ ID NO: 20: RBD of Sars-CoV-2 beta variant with N-terminal 
       signal peptide and with C-terminal His-tag

<400>  20

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            20                  25                  30          


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
        35                  40                  45              


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    50                  55                  60                  


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
65                  70                  75                  80  


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                85                  90                  95      


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            100                 105                 110         


Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        115                 120                 125             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
    130                 135                 140                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
145                 150                 155                 160 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                165                 170                 175     


Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe 
            180                 185                 190         


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln 
        195                 200                 205             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    210                 215                 220                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
225                 230                 235                 240 


Val Asn Phe His His His His His His 
                245                 


<210>  21
<211>  249
<212>  PRT
<213>  Unknown

<220>
<223>  SEQ ID NO: 21: RBD of S1 protein of Sars-CoV-2 omikron variant 
       (B1.1.529 (ZA 11/2021)) with N-terminal signal peptide and with 
       C-terminal His-tag

<400>  21

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            20                  25                  30          


Asn Ile Thr Asn Leu Cys Pro Phe Asp Glu Val Phe Asn Ala Thr Arg 
        35                  40                  45              


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    50                  55                  60                  


Ala Asp Tyr Ser Val Leu Tyr Asn Leu Ala Pro Phe Phe Thr Phe Lys 
65                  70                  75                  80  


Cys Tyr Ser Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                85                  90                  95      


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            100                 105                 110         


Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        115                 120                 125             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Lys Leu Asp 
    130                 135                 140                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
145                 150                 155                 160 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                165                 170                 175     


Ala Gly Asn Lys Pro Cys Asn Gly Val Ala Gly Phe Asn Cys Tyr Phe 
            180                 185                 190         


Pro Leu Lys Ser Tyr Ser Phe Arg Pro Thr Tyr Gly Val Gly His Gln 
        195                 200                 205             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    210                 215                 220                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
225                 230                 235                 240 


Val Asn Phe His His His His His His 
                245                 


<210>  22
<211>  750
<212>  DNA
<213>  Unknown

<220>
<223>  SEQ ID NO: 22: coding sequence of SEQ ID NO: 21, shown in Fig. 
       14.

<400>  22
atggaaaccc ctgctcagct gctgttcctg ctgctgctgt ggctgcctga taccaccgga       60

agagtgcagc ctaccgagtc catcgtgcgg ttccccaaca tcaccaacct gtgtcctttc      120

gacgaggtgt tcaacgccac cagattcgcc tctgtgtacg cctggaaccg gaagcggatc      180

tctaactgcg tggccgacta ctccgtgctg tacaatctgg ccccattctt caccttcaag      240

tgctacagcg tgtcccctac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      300

tccttcgtga tcagaggcga cgaagtgcgg cagatcgctc ctggacagac cggcaatatc      360

gccgactaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ttggaactcc      420

aacaagctgg actccaaagt cggcggcaac tacaattacc tgtaccggct gttccggaag      480

tccaacctga agcctttcga gcgggacatc tccaccgaga tctaccaggc tggcaacaag      540

ccttgtaatg gcgtggccgg cttcaactgc tacttcccac tgaagtccta cagcttccgg      600

cctacctacg gcgtgggcca ccagccttat agagtggtgg tgctgtcctt cgagctgctg      660

catgctcctg ctaccgtgtg cggccctaag aaatctacca acctggtcaa gaacaaatgc      720

gtgaacttcc accaccacca tcaccactga                                       750


<210>  23
<211>  243
<212>  PRT
<213>  artificial

<220>
<223>  SEQ ID NO: 21: RBD of S1 protein of Sars-CoV-2 omikron variant 
       (B1.1.529 (ZA 11/2021)) with N-terminal signal peptide

<400>  23

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            20                  25                  30          


Asn Ile Thr Asn Leu Cys Pro Phe Asp Glu Val Phe Asn Ala Thr Arg 
        35                  40                  45              


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    50                  55                  60                  


Ala Asp Tyr Ser Val Leu Tyr Asn Leu Ala Pro Phe Phe Thr Phe Lys 
65                  70                  75                  80  


Cys Tyr Ser Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                85                  90                  95      


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            100                 105                 110         


Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        115                 120                 125             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Lys Leu Asp 
    130                 135                 140                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
145                 150                 155                 160 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                165                 170                 175     


Ala Gly Asn Lys Pro Cys Asn Gly Val Ala Gly Phe Asn Cys Tyr Phe 
            180                 185                 190         


Pro Leu Lys Ser Tyr Ser Phe Arg Pro Thr Tyr Gly Val Gly His Gln 
        195                 200                 205             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    210                 215                 220                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
225                 230                 235                 240 


Val Asn Phe 
            


<210>  24
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 22: coding sequence of SEQ ID NO: 23

<400>  24
atggaaaccc ctgctcagct gctgttcctg ctgctgctgt ggctgcctga taccaccgga       60

agagtgcagc ctaccgagtc catcgtgcgg ttccccaaca tcaccaacct gtgtcctttc      120

gacgaggtgt tcaacgccac cagattcgcc tctgtgtacg cctggaaccg gaagcggatc      180

tctaactgcg tggccgacta ctccgtgctg tacaatctgg ccccattctt caccttcaag      240

tgctacagcg tgtcccctac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      300

tccttcgtga tcagaggcga cgaagtgcgg cagatcgctc ctggacagac cggcaatatc      360

gccgactaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ttggaactcc      420

aacaagctgg actccaaagt cggcggcaac tacaattacc tgtaccggct gttccggaag      480

tccaacctga agcctttcga gcgggacatc tccaccgaga tctaccaggc tggcaacaag      540

ccttgtaatg gcgtggccgg cttcaactgc tacttcccac tgaagtccta cagcttccgg      600

cctacctacg gcgtgggcca ccagccttat agagtggtgg tgctgtcctt cgagctgctg      660

catgctcctg ctaccgtgtg cggccctaag aaatctacca acctggtcaa gaacaaatgc      720

gtgaacttct ga                                                          732


