                    б

<110>  ïпƼ޹˾

<120>  BCMAĵ

<130>  0131-PA-021

<160>  56

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811 HFR1

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  2
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811 HCDR1;hu4811 HCDR1;hu4811FGLF HCDR1

<400>  2

Gly His Thr Pro Ser Asn Tyr Ala 
1               5               


<210>  3
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811 HFR2hu4811 HFR2

<400>  3

Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  15      


Ala 
    


<210>  4
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811 HCDR2;hu4811 HCDR2;hu4811FGLF HCDR2

<400>  4

Ile Thr Trp Ser Ala Val Thr Arg Asp Asp Ala Ile Pro 
1               5                   10              


<210>  5
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811 HFR3

<400>  5

Tyr Tyr Arg Thr Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  6
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811 HCDR3;hu4811 HCDR3;hu4811FGLF HCDR3

<400>  6

Ala Val Asp Ala Ser Leu Val Met Thr Pro Thr Pro Arg Tyr 
1               5                   10                  


<210>  7
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811 HFR4

<400>  7

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  8
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1 HFR1

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser 
            20                  25  


<210>  9
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1 HCDR1;huD1 HCDR1;huD1FGLF HCDR1

<400>  9

Gly Arg Thr Ser Thr Thr Ser Val 
1               5               


<210>  10
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1 HFR2;huD1 HFR2

<400>  10

Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Arg Phe Val Ala 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1 HCDR2;huD1 HCDR2;huD1FGLF HCDR2

<400>  11

Ile Thr Arg Thr Asp Asp Arg Gln Asn Asp Gly Ile Thr 
1               5                   10              


<210>  12
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1 HFR3

<400>  12

Tyr Tyr Gly Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Asp Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  13
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1 HCDR3;huD1 HCDR3;huD1FGLF HCDR3

<400>  13

Ala Ala His Thr Ser Leu Val Phe Thr Pro Asp Pro Arg Tyr 
1               5                   10                  


<210>  14
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1 HFR4

<400>  14

Trp Gly Gln Gly Thr Pro Val Thr Val Pro Ser 
1               5                   10      


<210>  15
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811ɱ

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Pro Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Trp Ser Ala Val Thr Arg Asp Asp Ala Ile Pro Tyr 
    50                  55                  60                  


Tyr Arg Thr Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
65                  70                  75                  80  


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Val Asp Ala Ser Leu Val Met Thr Pro Thr 
            100                 105                 110         


Pro Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  16
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1ɱ

<400>  16

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Ser Thr Thr Ser 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Arg Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Thr Asp Asp Arg Gln Asn Asp Gly Ile Thr Tyr 
    50                  55                  60                  


Tyr Gly Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp 
65                  70                  75                  80  


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Ala His Thr Ser Leu Val Phe Thr Pro Asp 
            100                 105                 110         


Pro Arg Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Pro Ser 
        115                 120                 125     


<210>  17
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C6ɱ)

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Thr Gly Ser 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ser Ser Gly His Ser Phe Ser Asp Tyr 
            20                  25                  30          


Ser Leu Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Trp Ser Asp Val Pro Arg Asp Asp Ala Val Thr Tyr 
    50                  55                  60                  


Tyr Arg Val Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
65                  70                  75                  80  


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Val Asp Ala Ser Leu Val Met Thr Leu Thr 
            100                 105                 110         


Pro Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  18
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C2ɱ

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Asp Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Ser Asp Glu Arg Gln Asn Asp Gly Val Thr Tyr 
    50                  55                  60                  


Tyr Arg Val Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
65                  70                  75                  80  


Asn Asp Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                85                  90                  95      


Ala Ile Tyr Tyr Cys Ala Ala Asp Pro Ser Leu Val Phe Ser Pro Thr 
            100                 105                 110         


Leu Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  19
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D10ɱ

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asn Asn Tyr 
            20                  25                  30          


Val Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Asp Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Ser Asp Glu Arg Gln Asn Asp Gly Val Thr Tyr 
    50                  55                  60                  


Tyr Arg Val Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
65                  70                  75                  80  


Asn Asp Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                85                  90                  95      


Ala Ile Tyr Tyr Cys Ala Ala Asp Pro Ser Leu Val Phe Ser Pro Thr 
            100                 105                 110         


Pro Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  20
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huD1ɱ

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Thr Thr Ser 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Arg Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Thr Asp Asp Arg Gln Asn Asp Gly Ile Thr Tyr 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
65                  70                  75                  80  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Ala His Thr Ser Leu Val Phe Thr Pro Asp 
            100                 105                 110         


Pro Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  21
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huD1FGLFɱ

<400>  21

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Thr Thr Ser 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Thr Asp Asp Arg Gln Asn Asp Gly Ile Thr Tyr 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
65                  70                  75                  80  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Ala His Thr Ser Leu Val Phe Thr Pro Asp 
            100                 105                 110         


Pro Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  22
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811ɱ

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Pro Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Trp Ser Ala Val Thr Arg Asp Asp Ala Ile Pro Tyr 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
65                  70                  75                  80  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Val Asp Ala Ser Leu Val Met Thr Pro Thr 
            100                 105                 110         


Pro Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  23
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811FGLFɱ

<400>  23

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Pro Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Trp Ser Ala Val Thr Arg Asp Asp Ala Ile Pro Tyr 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
65                  70                  75                  80  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Val Asp Ala Ser Leu Val Met Thr Pro Thr 
            100                 105                 110         


Pro Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  24
<211>  378
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  4811ɱ

<400>  24
caggtgcagc tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctggaca cacccccagt aattatgcca tgggctggtt ccgccagact      120

ccagggaagg agcgtgagtt cgtagcagct attacctgga gtgctgttac ccgggatgat      180

gcaataccat actatagaac ctccgtgaag ggccgattca ccatctcccg agacaacgcc      240

aagaacacgg tgtatctgca aatgaacagc ctgaaacctg aggacacggc cgtttattac      300

tgtgcagtag acgcttcatt ggtcatgacg cctacaccgc gctactgggg ccaggggacc      360

caggtcaccg tctcgtca                                                    378


<210>  25
<211>  378
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  D1ɱ

<400>  25
caggtgcagc tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgtgg cgtctggacg tacctcaacg acgtctgtca tgggctggtt ccgccaggcg      120

ccagggaagg agcgtaggtt tgtagcagct attacccgta ctgatgatcg ccagaatgat      180

ggtataacat actatggaga gtccgtgaag ggccgattca ccatctcccg agacaacgac      240

aagaacacgg tgtatctgca aatgaacagc ctgaaacctg aggacacggc cgtttattac      300

tgtgcagcac acacttcgtt ggtatttacg cctgacccgc gctactgggg ccaggggacc      360

ccggtcaccg tcccctca                                                    378


<210>  26
<211>  378
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  huD1ɱ

<400>  26
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggacg tacctcaacg acgtctgtca tgggctggtt ccgccaggcg      120

ccagggaagg agcgtaggtt tgtagcagct attacccgta ctgatgatcg ccagaatgat      180

ggtataacat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaattcc      240

aagaacacgc tgtatctgca aatgaacagc ctgagagccg aggacacggc cgtatattac      300

tgtgcagcac acacttcgtt ggtatttacg cctgacccgc gctactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210>  27
<211>  378
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  huD1FGLFɱ

<400>  27
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggacg tacctcaacg acgtctgtca tgggctggtt ccgccaggct      120

ccagggaagg ggctggagtt tgtcgcagct attacccgta ctgatgatcg ccagaatgat      180

ggtataacat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaattcc      240

aagaacacgc tgtatctgca aatgaacagc ctgagagccg aggacacggc cgtatattac      300

tgtgcagcac acacttcgtt ggtatttacg cctgacccgc gctactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210>  28
<211>  378
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811ɱ

<400>  28
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggaca cacccccagt aattatgcca tgggctggtt ccgccagact      120

ccagggaagg agcgtgagtt cgtagcagct attacctgga gtgctgttac ccgggatgat      180

gcaataccat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaattcc      240

aagaacacgc tgtatctgca aatgaacagc ctgagagccg aggacacggc cgtatattac      300

tgtgcagtag acgcttcatt ggtcatgacg cctacaccgc gctactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210>  29
<211>  378
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811FGLFɱ

<400>  29
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggaca cacccccagt aattatgcca tgggctggtt ccgccaggct      120

ccagggaagg ggctggagtt cgtcgcagct attacctgga gtgctgttac ccgggatgat      180

gcaataccat actacgcaga ctccgtgaag ggccggttca ccatctccag agacaattcc      240

aagaacacgc tgtatctgca aatgaacagc ctgagagccg aggacacggc cgtatattac      300

tgtgcagtag acgcttcatt ggtcatgacg cctacaccgc gctactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210>  30
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811 HFR1;hu4811FGLF HFR1;huD1 HFR1;huD1FGLF HFR1

<400>  30

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  31
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811 HFR3;hu4811FGLF HFR3;huD1 HFR3;huD1FGLF HFR3

<400>  31

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  32
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811 HFR4;hu4811FGLF HFR4;huD1 HFR4;huD1FGLF HFR4

<400>  32

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  33
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811FGLF HFR2;huD1FGLF HFR2

<400>  33

Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ala 
1               5                   10                  15      


Ala 
    


<210>  34
<211>  75
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811 HFR1;hu4811FGLF HFR1;huD1 HFR1;huD1FGLF HFR1

<400>  34
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctct                                                        75


<210>  35
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811 HCDR1Уhu4811FGLF HCDR1

<400>  35
ggacacaccc ccagtaatta tgcc                                              24


<210>  36
<211>  51
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811 HFR2

<400>  36
atgggctggt tccgccagac tccagggaag gagcgtgagt tcgtagcagc t                51


<210>  37
<211>  39
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811 HCDR2;hu4811FGLF HCDR2

<400>  37
attacctgga gtgctgttac ccgggatgat gcaatacca                              39


<210>  38
<211>  114
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811 HFR3;hu4811FGLF HFR3;huD1 HFR3;huD1FGLF HFR3

<400>  38
tactacgcag actccgtgaa gggccggttc accatctcca gagacaattc caagaacacg       60

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgt            114


<210>  39
<211>  42
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811 HCDR3;hu4811FGLF HCDR3

<400>  39
gcagtagacg cttcattggt catgacgcct acaccgcgct ac                          42


<210>  40
<211>  33
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811 HFR4;hu4811FGLF HFR4;huD1 HFR4;huD1FGLF HFR4

<400>  40
tggggccagg gaaccctggt caccgtctcc tca                                    33


<210>  41
<211>  51
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hu4811FGLF HFR2

<400>  41
atgggctggt tccgccaggc tccagggaag gggctggagt tcgtcgcagc t                51


<210>  42
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  huD1 HCDR1;huD1FGLF HCDR1

<400>  42
ggacgtacct caacgacgtc tgtc                                              24


<210>  43
<211>  51
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  huD1 HFR2

<400>  43
atgggctggt tccgccaggc gccagggaag gagcgtaggt ttgtagcagc t                51


<210>  44
<211>  39
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  huD1 HCDR2;huD1FGLF HCDR2

<400>  44
attacccgta ctgatgatcg ccagaatgat ggtataaca                              39


<210>  45
<211>  42
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  huD1 HCDR3УhuD1FGLF HCDR3

<400>  45
gcagcacaca cttcgttggt atttacgcct gacccgcgct ac                          42


<210>  46
<211>  51
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  huD1FGLF HFR2

<400>  46
atgggctggt tccgccaggc tccagggaag gggctggagt ttgtcgcagc t                51


<210>  47
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811/hu4811/hu4811FGLFͨʽ

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa = LeuArg

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa = AlaArg

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa = AspThr

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  Xaa = LeuGln

<400>  47

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Pro Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Xaa Pro Gly Lys Xaa Xaa Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Trp Ser Ala Val Thr Arg Asp Asp Ala Ile Pro Tyr 
    50                  55                  60                  


Tyr Xaa Xaa Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa 
65                  70                  75                  80  


Lys Asn Thr Xaa Tyr Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Val Asp Ala Ser Leu Val Met Thr Pro Thr 
            100                 105                 110         


Pro Arg Tyr Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120                 125     


<210>  48
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1/huD1/huD1FGLFͨʽ

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa = LeuArg

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa = GluArg

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = AspSer

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  Xaa = LeuPro

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  Xaa = ProSer

<400>  48

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Xaa Ala Ser Gly Arg Thr Ser Thr Thr Ser 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Xaa Xaa Xaa Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Thr Asp Asp Arg Gln Asn Asp Gly Ile Thr Tyr 
    50                  55                  60                  


Tyr Xaa Xaa Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa 
65                  70                  75                  80  


Lys Asn Thr Xaa Tyr Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Ala His Thr Ser Leu Val Phe Thr Pro Asp 
            100                 105                 110         


Pro Arg Tyr Trp Gly Gln Gly Thr Xaa Val Thr Val Xaa Ser 
        115                 120                 125     


<210>  49
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811/hu4811/hu4811FGLF HFR1ͨʽ

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AlaPro

<400>  49

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  50
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1/huD1/huD1FGLF HFR1ͨʽ

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = AlaVal

<400>  50

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Xaa Ala Ser 
            20                  25  


<210>  51
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811/hu4811/hu4811FGLF HFR2ͨʽ

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = LeuArg

<400>  51

Met Gly Trp Phe Arg Gln Xaa Pro Gly Lys Xaa Xaa Glu Phe Val Ala 
1               5                   10                  15      


Ala 
    


<210>  52
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1/huD1/huD1FGLF HFR2ͨʽ

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = LeuArg

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = GluArg

<400>  52

Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Xaa Xaa Xaa Phe Val Ala 
1               5                   10                  15      


Ala 
    


<210>  53
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811/hu4811/hu4811FGLF HFR3ͨʽ

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AlaArg

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AspThr

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = AlaPro

<400>  53

Tyr Tyr Xaa Xaa Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Xaa Lys Asn Thr Xaa Tyr Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  54
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1/huD1/huD1FGLF HFR3ͨʽ

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AspSer

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = AlaPro

<400>  54

Tyr Tyr Xaa Xaa Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Xaa Lys Asn Thr Xaa Tyr Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  55
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4811/hu4811/hu4811FGLF HFR4ͨʽ

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LeuGln

<400>  55

Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  D1/huD1/huD1FGLF HFR4ͨʽ

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LeuPro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = ProSer

<400>  56

Trp Gly Gln Gly Thr Xaa Val Thr Val Xaa Ser 
1               5                   10      



