б

<110>  ҽƴѧаҽԺ

<120>  ƱHBV cccDNAĺᡢϸ

<160>  9

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  552
<212>  DNA
<213>  Artificial Sequence

<400>  1
atggacattg acccgtataa agaatttgga gcatctgtgg agttactctc ttttttgcct        60
tctgacttct ttccttctat tcgagatctc ctcgacaccg cttctgctct gtatcgggag       120
gccttagagt ctccggaaca ttgttcacct caccatacag cactcaggca agctattctg       180
tgttggggtg agttgatgaa tctggccacc tgggtgggaa gtaatttgga agacccagca       240
tccagggaat tagtagtcag ctatgtcaat gttaatatgg gcctaaaaat cagacaacta       300
ttgtggtttc acatttcctg tcttactttt ggaagagaaa ctgttcttga gtatttggta       360
tcttttggag tgtggattcg cactcctccc gcttacagac caccaaatgc ccctatctta       420
tcaacacttc cggaaactac tgttgttaga cgacgaggca ggtcccctag aagaagaact       480
ccctcgcctc gcagacgaag atctcaatcg ccgcgtcgca gaagatctca atctcgggaa       540
tctcaatgtt ag                                                           552

<210>  2
<211>  2532
<212>  DNA
<213>  Artificial Sequence

<400>  2
atgcccctat cttatcaaca cttccggaaa ctactgttgt tagacgacga ggcaggtccc        60
ctagaagaag aactccctcg cctcgcagac gaagatctca atcgccgcgt cgcagaagat       120
ctcaatctcg ggaatctcaa tgttagtatc ccttggactc ataaggtggg aaactttact       180
gggctttatt cttctactgt acctgtcttt aatcccgagt ggcaaactcc ctcctttcct       240
cacattcatt tacaggagga cattattaat agatgtcaac aatatgtggg ccctcttaca       300
gttaatgaaa aaaggagatt aaaattaatt atgcctgcta ggttctatcc taaccttacc       360
aaatatttgc ccttagacaa aggcattaaa ccgtattatc ctgaacatgc agttaatcat       420
tacttcaaaa ctaggcatta tttacatact ctgtggaagg ctggcattct atataagaga       480
gaaactacac gcagcgcctc attttgtggg tcaccatatt cttgggaaca agagctacag       540
catgggaggt tggtcttcca aacctcgaca aggcatgggg acgaatcttt ctgttcccaa       600
tcctctggga ttctttcccg atcaccagtt ggaccctgcg ttcggagcca actcaaacaa       660
tccagattgg gacttcaacc ccaacaagga tcactggcca gaggcaaatc aggtaggagc       720
gggagcattc gggccagggt tcaccccacc acacggcggt cttttggggt ggagccctca       780
ggctcagggc atattgacaa cagtgccagc agcacctcct cctgcctcca ccaatcggca       840
gtcaggaaga cagcctactc ccatctctcc acctctaaga gacagtcatc ctcaggccat       900
gcagtggaac tccacaacat tccaccaagc tctgctagat cccagagtga ggggcctata       960
ttttcctgct ggtggctcca gttccggaac agtaaaccct gttccgacta ctgcctcacc      1020
catatcgtca atcttctcga ggactgggga ccctgcaccg aacatggaga acacaacatc      1080
aggattccta ggacccctgc tcgtgttaca ggcggggttt ttcttgttga caagaatcct      1140
cacaatacca cagagtctag actcgtggtg gacttctctc aattttctag ggggagcacc      1200
cacgtgtcct ggccaaaatt cgcagtcccc aacctccaat cactcaccaa cctcttgtcc      1260
tccaatttgt cctggctatc gctggatgtg tctgcggcgt tttatcatat tcctcttcat      1320
cctgctgcta tgcctcatct tcttgttggt tcttctggac taccaaggta tgttgcccgt      1380
ttgtcctcta cttccaggaa catcaaccac cagcacgggg ccatgcaaga cctgcacgat      1440
tcctgctcaa ggaacctcta tgtttccctc ttgttgctgt acaaaacctt cggacggaaa      1500
ctgcacttgt attcccatcc catcatcctg ggctttcgca agattcctat gggagtgggc      1560
ctcagtccgt ttctcctggc tcagtttact agtgccattt gttcagtggt tcgtagggct      1620
ttcccccact gtttggcttt cagttatatg gatgatgtgg tattgggggc caagtctgta      1680
caacatcttg agtccctttt tacctctatt accaattttc ttttgtcttt gggtatacat      1740
ttaaacccta ataaaaccaa acgttggggc tactccctta acttcatggg atatgtaatt      1800
ggaagttggg gtactttacc gcaggaacat attgtactaa aactcaagca atgttttcga      1860
aaattacctg taaatagacc tattgattgg aaagtctgtc aaagaattgt gggtcttttg      1920
ggctttgctg ccccttttac acaatgtggc tatcctgcct tgatgccttt atatgcatgt      1980
atacaatcta agcaggcttt cactttctcg ccaacttaca aggcctttct gtgtaaacaa      2040
tatctgaacc tttaccccgt tgcccggcaa cggtcaggtc tctgccaagt gtttgctgac      2100
gcaaccccca ctggatgggg cttggccata ggccatcggc gcatgcgtgg aacctttgtg      2160
gctcctctgc cgatccatac tgcggaactc ctagcagctt gtttcgctcg cagccggtct      2220
ggagcgaaac ttatcggcac cgacaactct gttgtcctct ctcggaaata cacctccttt      2280
ccatggctgc tagggtgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtctacgtc      2340
ccgtcggcgc tgaatcccgc ggacgacccg tctcggggcc gtttggggct ctaccgtccc      2400
cttcttcatc tgccgttccg gccgaccacg gggcgcacct ctctttacgc ggtctccccg      2460
tctgtgcctt ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg      2520
agaccaccgt ga                                                          2532

<210>  3
<211>  465
<212>  DNA
<213>  Artificial Sequence

<400>  3
atggctgcta gggtgtgctg ccaactggat cctgcgcggg acgtcctttg tctacgtccc        60
gtcggcgctg aatcccgcgg acgacccgtc tcggggccgt ttggggctct accgtcccct       120
tcttcatctg ccgttccggc cgaccacggg gcgcacctct ctttacgcgg tctccccgtc       180
tgtgccttct catctgccgg accgtgtgca cttcgcttca cctctgcacg tcgcatggag       240
accaccgtga acgcccacca ggtcttgccc aaggtcttac ataagaggac tcttggactc       300
tcagcaatgt caacgaccga ccttgaggca tacttcaaag actgtgtgtt taaagactgg       360
gaggagttgg gggaggagat taggttaaag gtctttgtac taggaggctg taggcataaa       420
ttggtctgtt caccagcacc atgcaacttt ttcacctctg cctaa                       465

<210>  4
<211>  570
<212>  DNA
<213>  Artificial Sequence

<400>  4
atggtgaatg gcgtgaaggt gctgtttgcc ctgatctgca ttgctgtggc tgaggccaag        60
cccacagaga acaatgagga cttcaacatt gtggctgtgg cctccaactt tgccaccacc       120
gacctggatg ccgacagggg caagctgcct ggcaagaagc tgcccctgga ggtgctgaag       180
gagatggagg ccaatgccag gaaggctggc tgcaccaggg gctgcctgat ctgcctgtcc       240
cacatcaagt gcacccccaa gatgaagaag ttcatccctg gccggtgcca cacctatgag       300
ggcgacaagg agtctgccca gggcggcatt ggcgaggcca ttgtggacat ccctgagatc       360
cctggcttca aggacctgga gcccatggag cagttcattg cccaggtgga cctgtgtgtg       420
gactgcacca ccggctgcct gaagggcctg gccaatgtgc agtgctctga cctgctgaag       480
aagtggctgc cccagagatg tgccaccttt gcctccaaaa tccagggcca ggtggacaag       540
atcaagggcg ctggcggcga tgacacctaa                                        570

<210>  5
<211>  375
<212>  DNA
<213>  Artificial Sequence

<400>  5
atggccaagt tgaccagtgc cgttccggtg ctcaccgcgc gcgacgtcgc cggagcggtc        60
gagttctgga ccgaccggct cgggttctcc cgggacttcg tggaggacga cttcgccggt       120
gtggtccggg acgacgtgac cctgttcatc agcgcggtcc aggaccaggt ggtgccggac       180
aacaccctgg cctgggtgtg ggtgcgcggc ctggacgagc tgtacgccga gtggtcggag       240
gtcgtgtcca cgaacttccg ggacgcctcc gggccggcca tgaccgagat cggcgagcag       300
ccgtgggggc gggagttcgc cctgcgcgac ccggccggca actgcgtgca cttcgtggcc       360
gaggagcagg actag                                                        375

<210>  6
<211>  4263
<212>  DNA
<213>  Artificial Sequence

<400>  6
ctgtggaatg tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt        60
atgcaaagca tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca       120
gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta       180
actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga       240
ctaatttttt ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag       300
tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata       360
tccattttcg gatctgatca gcacgtgttg acaattaatc atcggcatag tatatcggca       420
tagtataata cgacagacgc gtctaaacca tggccaagtt gaccagtgcc gttccggtgc       480
tcaccgcgcg cgacgtcgcc ggagcggtcg agttctggac cgaccggctc gggttctccc       540
gggacttcgt ggaggacgac ttcgccggtg tggtccggga cgacgtgacc ctgttcatca       600
gcgcggtcca ggaccaggtg gtgccggaca acaccctggc ctgggtgtgg gtgcgcggcc       660
tggacgagct gtacgccgag tggtcggagg tcgtgtccac gaacttccgg gacgcctccg       720
ggccggccat gaccgagatc ggcgagcagc cgtgggggcg ggagttcgcc ctgcgcgacc       780
cggccggcaa ctgcgtgcac ttcgtggccg aggagcagga cggatccggc gccaccaact       840
tctccctgct gaagcaggct ggcgatgtgg aggagaaccc tgggcccgac attgacccat       900
acaaggagtt tggcgcctct gtggagctgc tgtccttcct gccatctgac ttcttcccat       960
ccatcaggga cctgctcgac accgcctctg ctctgtatcg ggaggcctta gagtctccgg      1020
aacattgttc acctcaccat acagcactca ggcaagccat tctgtgttgg ggtgagttga      1080
tgaatctggc cacctgggtg ggaagtaatt tggaagatcc agcatccagg gaattagtag      1140
tcagctatgt caatgttaat atgggcctaa aaatcagaca actattgtgg tttcacattt      1200
cctgccttac ttttggaaga gaaactgttc ttgagtattt ggtgtctttt ggagtgtgga      1260
ttcgcactcc tcccgcttac agaccaccaa atgcccctat cttatcaaca cttccggaaa      1320
ctactgttgt tagatgtcga ggcaggtcca ctagaagaag aactccctcg cctcgcagac      1380
gaagatctca atcgccgcgt cgcagaagat ctcaatctcg ggaatctcaa tgttagtatc      1440
ccttggactc ataaggtggg aaactttact gggctttatt cttctactgt acctatcttt      1500
aatcctgagt ggcaaactcc ctcctttcct aacattcatt tacaggagga cattattaat      1560
agatgtcaac aatatgtggg ccctcttaca gttaatgaaa aaaggagatt aaaattaatt      1620
atgcctgcta ggttttatcc taaccttacc aaatatttgc ccttggataa aggcattaaa      1680
ccttattatc ctgaacatgc agttaatcat tacttcaaaa ctaggcatta tttacatact      1740
ctgtggaagg ctggcattct atataagaga gaaactacac gcagcgcttc attttgtggg      1800
tcaccatatt cttgggaaca agagctacag catgggaggt tggtcttcca aacctcgaca      1860
aggcatgggg acgaatcttt ctgttcccaa tcctctggga ttctttcccg atcaccagtt      1920
ggaccccgcg tttggagcca actcaaacaa tccagattgg gacttcaacc ccaacaagga      1980
tcaatggcca gaggcaaatc aggtaggagc gggagcattc gggccagggt tcaccccacc      2040
acacggcggt cttttggggt ggagccccca ggctcagggc atattgacaa cagtgccagc      2100
agctcctcct cctgcctcca ccaatcggca gtcaggaaga cagcctactc ccatctctcc      2160
acccataaga gacagtcatc ctcaggccat gcagtggaac tccaccacat tccaccaagc      2220
tctgctagat cctgctggtg gctccagttc cggaacagta aaccctgttc cgactactgc      2280
ctcacccata tcgtcaatct tctcgaggac tggggaccct gcaccgaaca tggagagcac      2340
aacatcagga ttcctaggac ccctgctcgt gttacaggcg gggtttttct tgttgacaag      2400
aatcctcaca ataccacaga gtctagactc gtggtggact tctctcaatt ttctaggggg      2460
agcaccaaag tgtcctggcc aaaattcgca gtccccaacc tccaatcact caccaacctc      2520
ttgtcctcca atttgtcctg gctatcgctg gatgtgtctg cggcgtttta tcatattcct      2580
cttcatcctg ntgctatgcc tcatcttctt gttggttctt ctggactacc aaggtatgtt      2640
gcccgtttgt cctctacttc caggaacatc aaccaccagc acgggaccat gcaagacctg      2700
cacgattcct gctcaaggaa cctctatgtt tccctcttgt tgctgtacaa aaccttcgga      2760
cggaaactgc acttgtattc ccatcccatc atcctgggct ttcgcaagat tcctatggga      2820
gtgggcctca gtccgtttct cctggctcag tttactagtg ccatttgttc agtggttcgt      2880
agggctttcc cccactgttt ggctttcagt tatatggatg atgtggtatt gggggccaag      2940
tctgtacaac atcttgagtc cctttatacc tctattacca attttctttt gtctttgggt      3000
atacatttga accctaataa aaccaaacgt tggggctact cccttaactt catgggatat      3060
gtaattggaa gttggggtac tttaccacag gaacatattg tactaaaaat caagcaatgt      3120
tttcggaaac tgcctgtaaa tagacctatt gattggaaag tgtgtcaaag aattgtgggt      3180
cttttgggct ttgctgcccc ttttacacag tgtggctatc ctgccttgat gcctttatat      3240
gcatgtatac aagctaagca ggctttcact ttctcgccaa cttacaaggc ctttctgtgt      3300
aaacaatatc tgcaccttta ccccgttgcc cggcaacggt ccggtctctg ccaagtgttt      3360
gctgacgcaa cccccactgg atggggcttg gccataggcc atcggcgcat gcgtggaacc      3420
tttgtggctc ctctgccgat ccatactgcg gaactcctag cagcttgttt tgctcgcagc      3480
cggtctggag caaaccttat cgggactgac aactctgttg tcctctctcg gaaatacacc      3540
tccttcccat ggctgctcgg gtgtgctgcc aactggatcc tgcgcgggac gtcgtttgtc      3600
tacgtcccgt cggcgctgaa tcccgcggac gacccgtctc ggggccgttt gggcctctat      3660
cgtccccttc ttcatctgcc gttccggccg accacggggc gcacctctct ttacgcggtc      3720
tccccgtctg tgccttctca tctgccggtc cgtgtgcact tcgcttcacc tctgcacgtc      3780
gcatggagac caccgtgaac gcccaccagg tcttgcccaa ggtcttacat aagaggactc      3840
ttggactctc agcaatgtca acgaccgacc ttgaggcata cttcaaagac tgtttgttta      3900
aagactggga ggagttgggg gaggagaata ggttaatgat ctttgtacta ggaggctgta      3960
ggcataaatt ggtctgtagc cccgccccct gtaacttctt tactagcgct taagtttaaa      4020
cccgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc      4080
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg      4140
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg      4200
acagcaaggg ggaggattgg gaagacaata gcaggcatgc gatcgcgtat acatctccag      4260
agg                                                                    4263

<210>  7
<211>  3449
<212>  DNA
<213>  Artificial Sequence

<400>  7
attaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta        60
cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt       120
caataatgac gtgagttccc atagtaacgc caatagggac tttccattga cgtcaatggg       180
aggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta       240
cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga       300
ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg       360
tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc       420
caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaatt caacgggact       480
ttccaaaatg tcgtaataac tccgccccat tgacgcaaat gggcggtagg cgtgtacgat       540
gggtggtcta tataagcgtc gagctccagc accttgcaac tttttcacct ctgcctaatc       600
atctcatgtt catgtcctac tgttcaagcc tccaagctgt gccttgggtg gctttggggc       660
ctggacattg acccgtataa agaatttgga gcttctgtgg agttactctc ttttttgcct       720
tctgacttct ttccttctat tcgaaccggt atgggtggct cgacgggcag agcgatggtg       780
gccaggctag ggctggggtt gctgcttctg gcactgctcc tacccacgca gatttactgc       840
aaccaaacat ctgttgcacc gtttcccggt aaccagaata tttctgcttc cccaaatcca       900
agtaacgcta ccaccagagg gggtggcagc tccctgcagt ccacagctgg tctcctggct       960
ctctctctct ctcttctaca tctctactgt gtgaatggcg tgaaggtgct gtttgccctg      1020
atctgcattg ctgtggctga ggccaagccc acagagaaca atgaggactt caacattgtg      1080
gctgtggcct ccaactttgc caccaccgac ctggatgccg acaggggcaa gctgcctggc      1140
aagaagctgc ccctggaggt gctgaaggag atggaggcca atgccaggaa ggctggctgc      1200
accaggggct gcctgatctg cctgtcccac atcaagtgca cccccaagat gaagaagttc      1260
atccctggcc ggtgccacac ctatgagggc gacaaggagt ctgcccaggg cggcattggc      1320
gaggccattg tggacatccc tgagatccct ggcttcaagg acctggagcc catggagcag      1380
ttcattgccc aggtggacct gtgtgtggac tgcaccaccg gctgcctgaa gggcctggcc      1440
aatgtgcagt gctctgacct gctgaagaag tggctgcccc agagatgtgc cacctttgcc      1500
tccaaaatcc agggccaggt ggacaagatc aagggcgctg gcggcgatga cacctaaagt      1560
cgacctcgac tcttacagtt aatgaaaaaa ggagattaaa attaattatg cctgctaggt      1620
tttatcctaa ccttaccaaa tatttgccct tggataaagg cattaaacct tattatcctg      1680
aacatgcagt taatcattac ttcaaaacta ggcattattt acatactctg tggaaggctg      1740
gcattctata taagagagaa actacacgca gcgcttcatt ttgtgggtca ccatattctt      1800
gggaacaaga gctacagcat tcaacaaggc atggggacga atctttctgt tcccaatcct      1860
ctgggattct ttcccgatca ccagttggat cctgcgtttg gagccaactc aaacaatcca      1920
gattgggact tcaaccccaa caaggatcaa tggccagagg caaatcaggt aggagcggga      1980
gcattcgggc cagggttcac cccaccacac ggcggtcttt tggggtggag cccccaggct      2040
cagggcatat tgacaacagt gccagcagct cctcctcctg cctccaccaa tcggcagtca      2100
ggaagacagc ctactcccat ctctccacct ctaagagaca gtcatcctca ggccatgcag      2160
tggaactcca ccacattcca ccaagctctg ctagatcctg ctggtggctc cagttccgga      2220
acagtaaacc ctgttccgac tactgcctca cccatatcgt caatcttctc gaggactggg      2280
gaccctgcac cgaacatgga gagcacaaca tcaggattcc taggacccct gctcgtgtta      2340
caggcggggt ttttcttgtt gacaagaatc ctcacaatac cacagagtct agaactagtc      2400
tttacacagt gtggctatcc tgccttgatg cctttatatg catgtataca agctaagcag      2460
gctttcactt tctcgccaac ttacaaggcc tttctgtgta aacaatatct gcacctttac      2520
cccgttgccc ggcaacggtc cggtctctgc caagtgtttg ctgacgcaac ccccactgga      2580
tggggcttgg ccataggcca tcggcgcatg cgtggaacct ttgtggctcc tctgccgatc      2640
catactgcgg aactcctagc agcttgtttt gctcgcagcc ggtctggagc aaaccttatc      2700
gggactgaca actctgttgt cctctctcgg aaatacacct ccttcccatg gctgctcggg      2760
tgtgctgcca actggatcct gcgcgggacg tcgtttgtct acgtcccgtc ggcgctgaat      2820
cccgcggacg acccgtctcg gggccgtttg ggcctctatc gtccccttct tcatctgccg      2880
ttccggccga ccacggggcg cacctctctt tacgcggtct ccccgtctgt gccttctcat      2940
ctgccggtcc gtgtgcactt cgcttcacct ctgcacgtcg catggagacc accgtgaacg      3000
cccaccaggt cttgcccaag gtcttacata agaggactct tggactctca gcaatgtcaa      3060
cgaccgacct tgaggcatac ttcaaagact gtttgtttaa agactgggag gagttggggg      3120
aggagaatag gttaaaggtc tttgtactag gaggctgtag gcataaattg gtctgttcac      3180
cagcaccaat gcaacttttt cacctctgcc taatcatctc atgttcatgt cctactgttc      3240
aagcctccaa gctgtgcctt gggtggcttt agggcatgga cattgacccg tataaagaat      3300
ttggagcttc tgtggagtta ctctcttttt tgccttctga cttctttcct tctattcgag      3360
atctcctcga caccgcctct gctctgtatc gggaggcctt agagtctccg gaacattgtt      3420
cacctcacca tacagcactc aggaattct                                        3449

<210>  8
<211>  30
<212>  DNA
<213>  Artificial Sequence

<400>  8
cttacataag aggactcttg gactctcagc                                         30

<210>  9
<211>  27
<212>  DNA
<213>  Artificial Sequence

<400>  9
ggacttcaac attgtggctg tggcctc                                            27

