                         SEQUENCE LISTING

<110>  Phoenix Eagle Pty. Ltd.
 
<120>  Antiviral Proteases and Methods of Use

<130>  PE004

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  771
<212>  PRT
<213>  Carica papya

<400>  1

Met Ala Val Ser Asn Pro Thr Leu Tyr Leu Leu Ser Phe Leu Leu Phe 
1               5                   10                  15      


Ser Ile Ser Leu Thr Pro Val Ile Ala Ser Lys Ser Ser Tyr Val Val 
            20                  25                  30          


Tyr Leu Gly Ala His Ser His Gly Leu Glu Leu Ser Ser Ala Asp Leu 
        35                  40                  45              


Asp Arg Val Lys Glu Ser His Tyr Asp Phe Leu Gly Ser Phe Leu Gly 
    50                  55                  60                  


Ser Pro Glu Glu Ala Gln Glu Ser Ile Phe Tyr Ser Tyr Thr Lys His 
65                  70                  75                  80  


Ile Asn Gly Phe Ala Ala Glu Leu Asn Asp Glu Val Ala Ala Lys Leu 
                85                  90                  95      


Ala Lys His Pro Lys Val Val Ser Val Phe Leu Asn Lys Gly Arg Lys 
            100                 105                 110         


Leu His Thr Thr Arg Ser Trp Asp Phe Leu Gly Leu Glu Gln Asn Gly 
        115                 120                 125             


Val Val Pro Ser Ser Ser Ile Trp Lys Lys Ala Arg Phe Gly Glu Asp 
    130                 135                 140                 


Thr Ile Ile Gly Asn Leu Asp Thr Gly Val Trp Pro Glu Ser Lys Ser 
145                 150                 155                 160 


Phe Ser Asp Glu Gly Leu Gly Pro Ile Pro Ser Lys Trp Arg Gly Ile 
                165                 170                 175     


Cys Asp His Gly Lys Asp Ser Ser Phe His Cys Asn Arg Lys Leu Ile 
            180                 185                 190         


Gly Ala Arg Phe Phe Asn Arg Gly Tyr Ala Ser Ala Val Gly Ser Leu 
        195                 200                 205             


Asn Ser Ser Phe Glu Ser Pro Arg Asp Asn Glu Gly His Gly Thr His 
    210                 215                 220                 


Thr Leu Ser Thr Ala Gly Gly Asn Met Val Ala Asn Ala Ser Val Phe 
225                 230                 235                 240 


Gly Leu Gly Lys Gly Thr Ala Lys Gly Gly Ser Pro Arg Ala Arg Val 
                245                 250                 255     


Ala Ala Tyr Lys Val Cys Trp Pro Pro Val Leu Gly Asn Glu Cys Phe 
            260                 265                 270         


Asp Ala Asp Ile Leu Ala Ala Phe Asp Ala Ala Ile His Asp Arg Val 
        275                 280                 285             


Asp Val Leu Ser Val Ser Leu Gly Gly Thr Ala Gly Gly Phe Phe Asn 
    290                 295                 300                 


Asp Ser Val Ala Ile Gly Ser Phe His Ala Val Lys His Gly Ile Val 
305                 310                 315                 320 


Val Val Cys Ser Ala Gly Asn Ser Gly Pro Asp Asp Gly Ser Val Ser 
                325                 330                 335     


Asn Val Ala Pro Trp Gln Ile Thr Val Gly Ala Ser Thr Met Asp Arg 
            340                 345                 350         


Glu Phe Pro Ser Tyr Val Leu Leu Gly Asn Asn Met Ser Phe Lys Gly 
        355                 360                 365             


Glu Ser Leu Ser Asp Ala Val Leu Pro Gly Thr Asn Phe Phe Pro Leu 
    370                 375                 380                 


Ile Ser Ala Leu Asn Ala Lys Ala Thr Asn Ala Ser Asn Glu Glu Ala 
385                 390                 395                 400 


Ile Leu Cys Glu Ala Gly Ala Leu Asp Pro Lys Lys Val Lys Gly Lys 
                405                 410                 415     


Ile Leu Val Cys Leu Arg Gly Leu Asn Ala Arg Val Asp Lys Gly Gln 
            420                 425                 430         


Gln Ala Ala Leu Ala Gly Ala Val Gly Met Ile Leu Ala Asn Ser Glu 
        435                 440                 445             


Leu Asn Gly Asn Glu Ile Ile Ala Asp Ala His Val Leu Pro Ala Ser 
    450                 455                 460                 


His Ile Ser Phe Thr Asp Gly Leu Ser Val Phe Glu Tyr Ile Asn Leu 
465                 470                 475                 480 


Thr Asn Ser Pro Val Ala Tyr Met Thr Arg Pro Lys Thr Lys Leu Pro 
                485                 490                 495     


Thr Lys Pro Ala Pro Val Met Ala Ala Phe Ser Ser Lys Gly Pro Asn 
            500                 505                 510         


Ile Val Thr Pro Glu Ile Leu Lys Pro Asp Ile Thr Ala Pro Gly Val 
        515                 520                 525             


Asn Val Ile Ala Ala Tyr Thr Arg Ala Gln Gly Pro Thr Asn Gln Asn 
    530                 535                 540                 


Phe Asp Arg Arg Arg Val Gln Phe Asn Ser Val Ser Gly Thr Ser Met 
545                 550                 555                 560 


Ser Cys Pro His Val Ser Gly Ile Val Gly Leu Leu Lys Thr Leu Tyr 
                565                 570                 575     


Pro Ser Trp Ser Pro Ala Ala Ile Arg Ser Ala Ile Met Thr Ser Ala 
            580                 585                 590         


Thr Thr Met Asp Asn Ile Asn Glu Ser Ile Leu Asn Ala Ser Asn Val 
        595                 600                 605             


Lys Ala Thr Pro Phe Ser Tyr Gly Ala Gly His Val Gln Pro Asn Gln 
    610                 615                 620                 


Ala Met Asn Pro Gly Leu Val Tyr Asp Leu Asn Thr Lys Asp Tyr Leu 
625                 630                 635                 640 


Lys Phe Leu Cys Ala Leu Gly Tyr Ser Lys Thr Leu Ile Ser Ile Phe 
                645                 650                 655     


Ser Asn Asp Lys Phe Asn Cys Pro Arg Thr Asn Ile Ser Leu Ala Asp 
            660                 665                 670         


Phe Asn Tyr Pro Ser Ile Thr Val Pro Glu Leu Lys Gly Leu Ile Thr 
        675                 680                 685             


Leu Ser Arg Lys Val Lys Asn Val Gly Ser Pro Thr Thr Tyr Arg Val 
    690                 695                 700                 


Thr Val Gln Lys Pro Lys Gly Ile Ser Val Thr Val Lys Pro Lys Ile 
705                 710                 715                 720 


Leu Lys Phe Lys Lys Ala Gly Glu Glu Lys Ser Phe Thr Val Thr Leu 
                725                 730                 735     


Lys Met Lys Ala Lys Asn Pro Thr Lys Glu Tyr Val Phe Gly Glu Leu 
            740                 745                 750         


Val Trp Ser Asp Glu Asp Glu His Tyr Val Arg Ser Pro Ile Val Val 
        755                 760                 765             


Lys Ala Ala 
    770     


<210>  2
<211>  13
<212>  PRT
<213>  Carica papaya

<400>  2

Ser Phe Ser Asp Glu Gly Leu Gly Pro Ile Pro Ser Lys 
1               5                   10              


<210>  3
<211>  24
<212>  PRT
<213>  Carica papaya

<400>  3

Gly Glu Ser Leu Ser Asp Ala Val Leu Pro Gly Thr Asn Phe Phe Pro 
1               5                   10                  15      


Leu Ile Ser Ala Leu Asn Ala Lys 
            20                  


<210>  4
<211>  27
<212>  PRT
<213>  Carica papaya

<400>  4

Gly Pro Asn Ile Val Thr Pro Glu Ile Leu Lys Pro Asp Ile Thr Ala 
1               5                   10                  15      


Pro Gly Val Asn Val Ile Ala Ala Tyr Thr Arg 
            20                  25          


<210>  5
<211>  12
<212>  PRT
<213>  Carica papaya

<400>  5

Thr Leu Tyr Pro Ser Trp Ser Pro Ala Ala Ile Arg 
1               5                   10          


<210>  6
<211>  1273
<212>  PRT
<213>  SARS-CoV-2 virus

<400>  6

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Thr Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


       