                         SEQUENCE LISTING

<110>  D-10 THERAPEUTICS, INC.
 
<120>  ANTI-CD47 ANTIBODIES AND USES THEREOF

<130>  D10T-001/01WO 332075-2003

<150>  US 63/129,716
<151>  2020-12-23

<160>  244   

<170>  PatentIn version 3.5

<210>  1
<211>  417
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  1
atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt caattcagag       60

gttcagctgc agcagtctgg gacagaactt gtgaagccag gggcctcagt caggttgtcc      120

tgcacagctt ctggcctcga cattaaagac acctatatgc actggttgaa acagaggcct      180

gaacagggcc tggagtggat tgggaggatt gatcctgcga gtggcaatgc taaacatgac      240

ccgaagttcc agggcaaggc cactataaca tcagacccat cctccaacac agccaattta      300

cagctcacca gcctaacatc tgaggacagt gccgtctatt actgtgcctc cggctatggt      360

cactacgtcg gtgctatgga ctactggggt caaggtacct cagtcaccgt ctcctca         417


<210>  2
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  2
gaggttcagc tgcagcagtc tgggacagaa cttgtgaagc caggggcctc agtcaggttg       60

tcctgcacag cttctggcct cgacattaaa gacacctata tgcactggtt gaaacagagg      120

cctgaacagg gcctggagtg gattgggagg attgatcctg cgagtggcaa tgctaaacat      180

gacccgaagt tccagggcaa ggccactata acatcagacc catcctccaa cacagccaat      240

ttacagctca ccagcctaac atctgaggac agtgccgtct attactgtgc ctccggctat      300

ggtcactacg tcggtgctat ggactactgg ggtcaaggta cctcagtcac cgtctcctca      360


<210>  3
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain signal sequence

<400>  3
atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt caattca          57


<210>  4
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR1

<400>  4
gaggttcagc tgcagcagtc tgggacagaa cttgtgaagc caggggcctc agtcaggttg       60

tcctgcacag cttctggcct cgacattaaa                                        90


<210>  5
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR1

<400>  5
gacacctata tgcac                                                        15


<210>  6
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR2

<400>  6
tggttgaaac agaggcctga acagggcctg gagtggattg gg                          42


<210>  7
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR2

<400>  7
aggattgatc ctgcgagtgg caatgctaaa catgacccga agttccaggg c                51


<210>  8
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR3

<400>  8
aaggccacta taacatcaga cccatcctcc aacacagcca atttacagct caccagccta       60

acatctgagg acagtgccgt ctattactgt gcctcc                                 96


<210>  9
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR3

<400>  9
ggctatggtc actacgtcgg tgctatggac tac                                    33


<210>  10
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR4

<400>  10
tggggtcaag gtacctcagt caccgtctcc tca                                    33


<210>  11
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  11

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Leu Ser Cys Thr Ala Ser Gly Leu Asp Ile 
        35                  40                  45              


Lys Asp Thr Tyr Met His Trp Leu Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Ser Gly Asn Ala Lys His Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Ser Asp Pro Ser Ser Asn 
                85                  90                  95      


Thr Ala Asn Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Gly Tyr Gly His Tyr Val Gly Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 


<210>  12
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  12

Glu Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Thr Ala Ser Gly Leu Asp Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Leu Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ser Gly Asn Ala Lys His Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ser Asp Pro Ser Ser Asn Thr Ala Asn 
65                  70                  75                  80  


Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Tyr Gly His Tyr Val Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain signal sequence

<400>  13

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser 
            


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR1

<400>  14

Glu Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Thr Ala Ser Gly Leu Asp Ile Lys 
            20                  25                  30  


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR1

<400>  15

Asp Thr Tyr Met His 
1               5   


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR2

<400>  16

Trp Leu Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR2

<400>  17

Arg Ile Asp Pro Ala Ser Gly Asn Ala Lys His Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR3

<400>  18

Lys Ala Thr Ile Thr Ser Asp Pro Ser Ser Asn Thr Ala Asn Leu Gln 
1               5                   10                  15      


Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR3

<400>  19

Gly Tyr Gly His Tyr Val Gly Ala Met Asp Tyr 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR4

<400>  20

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  21
atgagggtcc ttgctgagct cctggggctg ctgctgttct gctttttagg tgtgagatgt       60

gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc      120

atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca      180

ggaaatattc ctaaactatt gatctataag gcttccaatt tgcacacagg cgtcccatca      240

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      300

gaggacattg ccacttacta ctgtcaacag agtcggaatt atccgtacac gttcggaggg      360

gggaccaagc tggaaataaa a                                                381


<210>  22
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  22
gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc       60

atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca      120

ggaaatattc ctaaactatt gatctataag gcttccaatt tgcacacagg cgtcccatca      180

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      240

gaggacattg ccacttacta ctgtcaacag agtcggaatt atccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  23
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain signal sequence

<400>  23
atgagggtcc ttgctgagct cctggggctg ctgctgttct gctttttagg tgtgagatgt       60


<210>  24
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR1

<400>  24
gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc       60

atcacttgc                                                               69


<210>  25
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR1

<400>  25
catgccagtc agaacattaa tgtttggtta agc                                    33


<210>  26
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR2

<400>  26
tggtaccagc agaaaccagg aaatattcct aaactattga tctat                       45


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR2

<400>  27
aaggcttcca atttgcacac a                                                 21


<210>  28
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR3

<400>  28
ggcgtcccat caaggtttag tggcagtgga tctggaacag gtttcacatt aaccatcagc       60

agcctgcagc ctgaggacat tgccacttac tactgt                                 96


<210>  29
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR3

<400>  29
caacagagtc ggaattatcc gtacacg                                           27


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR4

<400>  30
ttcggagggg ggaccaagct ggaaataaaa                                        30


<210>  31
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  31

Met Arg Val Leu Ala Glu Leu Leu Gly Leu Leu Leu Phe Cys Phe Leu 
1               5                   10                  15      


Gly Val Arg Cys Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn 
        35                  40                  45              


Ile Asn Val Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
            100                 105                 110         


Asn Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  32

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Asn Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain signal sequence

<400>  33

Met Arg Val Leu Ala Glu Leu Leu Gly Leu Leu Leu Phe Cys Phe Leu 
1               5                   10                  15      


Gly Val Arg Cys 
            20  


<210>  34
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR1

<400>  34

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys 
            20              


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR1

<400>  35

His Ala Ser Gln Asn Ile Asn Val Trp Leu Ser 
1               5                   10      


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR2

<400>  36

Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR2

<400>  37

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  38
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR3

<400>  38

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR3

<400>  39

Gln Gln Ser Arg Asn Tyr Pro Tyr Thr 
1               5                   


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR4

<400>  40

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  41
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  41
atggaatgga gttggatatt tctctttctc ctgtcaggaa ctgcaggtgt ccactctgag       60

gtccagctgc agcagtctgg acctgaactg gtaaagcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggatacac attcactagc tctgttatgc actgggtgaa gcagaagcct      180

gggcagggcc ttgagtggct tggatatatt aatccttata gtgatggaac taaattcaat      240

gagaagtaca aaaccaaggc cacactgact tcagacaaat cctccagcac agcctacatg      300

gaactcagca gcctgacctc tgaggactct gcggtctatt actgtgcaag aggccttata      360

gggactagat acgactcctg gtttgcttac tggggccaag ggactctggt cactgtctct      420

gca                                                                    423


<210>  42
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  42
gaggtccagc tgcagcagtc tggacctgaa ctggtaaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggata cacattcact agctctgtta tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gcttggatat attaatcctt atagtgatgg aactaaattc      180

aatgagaagt acaaaaccaa ggccacactg acttcagaca aatcctccag cacagcctac      240

atggaactca gcagcctgac ctctgaggac tctgcggtct attactgtgc aagaggcctt      300

atagggacta gatacgactc ctggtttgct tactggggcc aagggactct ggtcactgtc      360

tctgca                                                                 366


<210>  43
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain signal sequence

<400>  43
atggaatgga gttggatatt tctctttctc ctgtcaggaa ctgcaggtgt ccactct          57


<210>  44
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR1

<400>  44
gaggtccagc tgcagcagtc tggacctgaa ctggtaaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggata cacattcact                                        90


<210>  45
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR1

<400>  45
agctctgtta tgcac                                                        15


<210>  46
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR2

<400>  46
tgggtgaagc agaagcctgg gcagggcctt gagtggcttg ga                          42


<210>  47
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR2

<400>  47
tatattaatc cttatagtga tggaactaaa ttcaatgaga agtacaaaac c                51


<210>  48
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR3

<400>  48
aaggccacac tgacttcaga caaatcctcc agcacagcct acatggaact cagcagcctg       60

acctctgagg actctgcggt ctattactgt gcaaga                                 96


<210>  49
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR3

<400>  49
ggccttatag ggactagata cgactcctgg tttgcttac                              39


<210>  50
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR4

<400>  50
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  51
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  51

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Ser Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn 
65                  70                  75                  80  


Glu Lys Tyr Lys Thr Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140     


<210>  52
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  52

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn Glu Lys Tyr 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  53
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain signal sequence

<400>  53

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  54
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR1

<400>  54

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR1

<400>  55

Ser Ser Val Met His 
1               5   


<210>  56
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR2

<400>  56

Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR2

<400>  57

Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn Glu Lys Tyr Lys 
1               5                   10                  15      


Thr 
    


<210>  58
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR3

<400>  58

Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  59
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR3

<400>  59

Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe Ala Tyr 
1               5                   10              


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR4

<400>  60

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  61
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  61
atgtcctctg ctcagttcct tggtctcctg ttgctctgtt ttcaaggtat cagatgtgat       60

atccagatga cacagaatgc atcctccctg tctgcctctc tgggagacag agtcaccatc      120

agttgcagga caagtcagga cattaacaat tatttaaatt ggtatcagca gaaaccagat      180

ggaactgtta aactcctgat ctattacaca tcaagattac actcaggagt cccatcaagg      240

ttcagtggca gtgggtctgg aacagattat tctctctcca ttcgctacct ggagcaagaa      300

gatattgcca cttacttttg ccaccagggt aatacacttc cgtacacgtt cggagggggg      360

accaaactgg aaataaaa                                                    378


<210>  62
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  62
gatatccaga tgacacagaa tgcatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca ggacaagtca ggacattaac aattatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctattac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctct ccattcgcta cctggagcaa      240

gaagatattg ccacttactt ttgccaccag ggtaatacac ttccgtacac gttcggaggg      300

gggaccaaac tggaaataaa a                                                321


<210>  63
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain signal sequence

<400>  63
atgtcctctg ctcagttcct tggtctcctg ttgctctgtt ttcaaggtat cagatgt          57


<210>  64
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR1

<400>  64
gatatccaga tgacacagaa tgcatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgc                                                               69


<210>  65
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR1

<400>  65
aggacaagtc aggacattaa caattattta aat                                    33


<210>  66
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR2

<400>  66
tggtatcagc agaaaccaga tggaactgtt aaactcctga tctat                       45


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR2

<400>  67
tacacatcaa gattacactc a                                                 21


<210>  68
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR3

<400>  68
ggagtcccat caaggttcag tggcagtggg tctggaacag attattctct ctccattcgc       60

tacctggagc aagaagatat tgccacttac ttttgc                                 96


<210>  69
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR3

<400>  69
caccagggta atacacttcc gtacacg                                           27


<210>  70
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR4

<400>  70
ttcggagggg ggaccaaact ggaaataaaa                                        30


<210>  71
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  71

Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln Gly 
1               5                   10                  15      


Ile Arg Cys Asp Ile Gln Met Thr Gln Asn Ala Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Thr Ser Gln Asp Ile 
        35                  40                  45              


Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Ser Ile Arg Tyr 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys His Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  72
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  72

Asp Ile Gln Met Thr Gln Asn Ala Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Thr Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Ser Ile Arg Tyr Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys His Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  73
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain signal sequence

<400>  73

Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln Gly 
1               5                   10                  15      


Ile Arg Cys 
            


<210>  74
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR1

<400>  74

Asp Ile Gln Met Thr Gln Asn Ala Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR1

<400>  75

Arg Thr Ser Gln Asp Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR2

<400>  76

Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR2

<400>  77

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  78
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR3

<400>  78

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
1               5                   10                  15      


Leu Ser Ile Arg Tyr Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR3

<400>  79

His Gln Gly Asn Thr Leu Pro Tyr 
1               5               


<210>  80
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  81
<211>  417
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  81
atggaatgga gttggatatt tctctttctc ctgtcaggaa ctgcaggtgt ccactctgag       60

gtccagctgc agcagtctgg acctgagctg gtacagcctg gggcttcagt gaggatgtcc      120

tgcaaggctt ctggatacac gttcactagc tatgttatgc actgggtgaa gcagaagcct      180

gggcagggcc ttgagtggat tggatatatt aatccttaca atgatggtac taagtataat      240

gagaagttca aaggcaaggc cacactgact tcagacaaat cctccagcac agcctacatg      300

gagctcagca gcctgacctc tgaggactct gcggtctatt actgtgcaag aggaaggaat      360

aggtacgacg gttggtttac ttactggggc caagggactc tggtcactgt ctctgca         417


<210>  82
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  82
gaggtccagc tgcagcagtc tggacctgag ctggtacagc ctggggcttc agtgaggatg       60

tcctgcaagg cttctggata cacgttcact agctatgtta tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat attaatcctt acaatgatgg tactaagtat      180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctac      240

atggagctca gcagcctgac ctctgaggac tctgcggtct attactgtgc aagaggaagg      300

aataggtacg acggttggtt tacttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  83
<211>  323
<212>  PRT
<213>  Macaca fascicularis

<400>  83

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Ala Pro Ala Asn 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Met Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  84
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR1

<400>  84
gaggtccagc tgcagcagtc tggacctgag ctggtacagc ctggggcttc agtgaggatg       60

tcctgcaagg cttctggata cacgttcact                                        90


<210>  85
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR1

<400>  85
agctatgtta tgcac                                                        15


<210>  86
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR2

<400>  86
tgggtgaagc agaagcctgg gcagggcctt gagtggattg ga                          42


<210>  87
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR2

<400>  87
tatattaatc cttacaatga tggtactaag tataatgaga agttcaaagg c                51


<210>  88
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR3

<400>  88
aaggccacac tgacttcaga caaatcctcc agcacagcct acatggagct cagcagcctg       60

acctctgagg actctgcggt ctattactgt gcaaga                                 96


<210>  89
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR3

<400>  89
ggaaggaata ggtacgacgg ttggtttact tac                                    33


<210>  90
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR4

<400>  90
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  91
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  91

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Gln 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Arg Asn Arg Tyr Asp Gly Trp Phe Thr Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 


<210>  92
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  92

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Asn Arg Tyr Asp Gly Trp Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  93
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR1

<400>  93

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR1

<400>  94

Ser Tyr Val Met His 
1               5   


<210>  95
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR2

<400>  95

Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  96
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR2

<400>  96

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  97
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AA Junction

<400>  97

Cys Ala Ser Gly Tyr Gly His Tyr Val Gly Ala Met Asp Tyr Trp 
1               5                   10                  15  


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR3

<400>  98

Gly Arg Asn Arg Tyr Asp Gly Trp Phe Thr Tyr 
1               5                   10      


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AA Junction

<400>  99

Cys Gln Gln Ser Arg Asn Tyr Pro Tyr Thr Phe 
1               5                   10      


<210>  100
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  100
atgtcctctg ctcagttcct tggtctcctg ttgctctgtt ttcaaggtat cagatgtgat       60

atccagatga cacagactac attctccctg tctgcctctc tgggagacag agtcaccatc      120

agttgcaggg caagtcagga cattagtaat tatttaaact ggtatcagca gaaaccagat      180

ggaactgtta aactcctgat ctactacaca tcaagattac actcaggagt cccatcaagg      240

ttcagtggca gtgggtctgg aacagattat tctctcacca ttagcaacct ggagcaagaa      300

gatattgcca cttacttttg ccaacagggt aatacgcttc cgtacacgtt cggagggggg      360

accaagctgg aaataaaa                                                    378


<210>  101
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  101
gatatccaga tgacacagac tacattctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  102
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain signal sequence

<400>  102
atgtcctctg ctcagttcct tggtctcctg ttgctctgtt ttcaaggtat cagatgt          57


<210>  103
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR1

<400>  103
gatatccaga tgacacagac tacattctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgc                                                               69


<210>  104
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR1

<400>  104
agggcaagtc aggacattag taattattta aac                                    33


<210>  105
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR2

<400>  105
tggtatcagc agaaaccaga tggaactgtt aaactcctga tctac                       45


<210>  106
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR3

<400>  106
ggagtcccat caaggttcag tggcagtggg tctggaacag attattctct caccattagc       60

aacctggagc aagaagatat tgccacttac ttttgc                                 96


<210>  107
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR3

<400>  107
caacagggta atacgcttcc gtacacg                                           27


<210>  108
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR4

<400>  108
ttcggagggg ggaccaagct ggaaataaaa                                        30


<210>  109
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  109

Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln Gly 
1               5                   10                  15      


Ile Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Phe Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  110
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  110

Asp Ile Gln Met Thr Gln Thr Thr Phe Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  111
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR1

<400>  111

Asp Ile Gln Met Thr Gln Thr Thr Phe Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR1

<400>  112

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  113
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR2

<400>  113

Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  114
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR3

<400>  114

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR3

<400>  115

Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  116
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AA Junction

<400>  116

Cys Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe Ala Tyr 
1               5                   10                  15      


Trp 
    


<210>  117
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  117
atggaatgga gttggatatt tctctttctc ctgtcaggaa ctgcaggtgt ccactctgag       60

gtccagctgc agcagtctgg acctgagctg gtaaagcctg gggcttcagt gaagatgtcc      120

tgcaaggctt ctggatacac attcactagc tatgttatgc actgggtgaa gcagaagcct      180

gggcagggcc ttgagtggat gggatatatt aatccttaca atgatggtac taagtacaat      240

gagaagttca aaggcaaggc cacactgact tcagacaaat cctccaacac agcctacatg      300

gagttcagca gcctgacctc tgaggactct gcggtctatt actgtgcaag aatagactac      360

ggtactatcc acacgtcctg gtttgcttac tggggccaag ggactctggt cactgtctct      420

gca                                                                    423


<210>  118
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  118
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact agctatgtta tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gatgggatat attaatcctt acaatgatgg tactaagtac      180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccaa cacagcctac      240

atggagttca gcagcctgac ctctgaggac tctgcggtct attactgtgc aagaatagac      300

tacggtacta tccacacgtc ctggtttgct tactggggcc aagggactct ggtcactgtc      360

tctgca                                                                 366


<210>  119
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AA Junction

<400>  119

Cys His Gln Gly Asn Thr Leu Pro Tyr Thr Phe 
1               5                   10      


<210>  120
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR1

<400>  120
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact                                        90


<210>  121
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR2

<400>  121
tgggtgaagc agaagcctgg gcagggcctt gagtggatgg ga                          42


<210>  122
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR2

<400>  122
tatattaatc cttacaatga tggtactaag tacaatgaga agttcaaagg c                51


<210>  123
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR3

<400>  123
aaggccacac tgacttcaga caaatcctcc aacacagcct acatggagtt cagcagcctg       60

acctctgagg actctgcggt ctattactgt gcaaga                                 96


<210>  124
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR3

<400>  124
atagactacg gtactatcca cacgtcctgg tttgcttac                              39


<210>  125
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR4

<400>  125
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  126
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  126

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ile Asp Tyr Gly Thr Ile His Thr Ser Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140     


<210>  127
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  127

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Asp Tyr Gly Thr Ile His Thr Ser Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  128
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR1

<400>  128

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  129
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR2

<400>  129

Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  130
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR3

<400>  130

Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Asn Thr Ala Tyr Met Glu 
1               5                   10                  15      


Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  131
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR3

<400>  131

Ile Asp Tyr Gly Thr Ile His Thr Ser Trp Phe Ala Tyr 
1               5                   10              


<210>  132
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AA Junction

<400>  132

Cys Ala Arg Gly Arg Asn Arg Tyr Asp Gly Trp Phe Thr Tyr Trp 
1               5                   10                  15  


<210>  133
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  133
atgtcctctg ctcagttcct tggtctcctg ttgctctgtt ttcaaggtac cagatgtgat       60

atccagatga cacacactac atcctccctg tctgcctctc tgggagacag agtcaccatc      120

agttgcaggg caagtcagga cattagcaat tatttaaact ggtatcagca gaaaccagat      180

ggaactgtta aactcctgat ctactacaca tcaagattac actcaggagt cccatcaagg      240

ttcagtggca gtgggtctgg aacagattat tctctcacca ttagcaacct ggagcaagaa      300

gatattgcca cttacttttg ccaacagggt aatacgcttc cgtggacgtt cggtggaggc      360

accaaactgg aaatcaaa                                                    378


<210>  134
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  134
gatatccaga tgacacacac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtggac gttcggtgga      300

ggcaccaaac tggaaatcaa a                                                321


<210>  135
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain signal sequence

<400>  135
atgtcctctg ctcagttcct tggtctcctg ttgctctgtt ttcaaggtac cagatgt          57


<210>  136
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR1

<400>  136
gatatccaga tgacacacac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgc                                                               69


<210>  137
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR1

<400>  137
agggcaagtc aggacattag caattattta aac                                    33


<210>  138
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR2

<400>  138
tggtatcagc agaaaccaga tggaactgtt aaactcctga tctac                       45


<210>  139
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AA Junction

<400>  139

Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe 
1               5                   10      


<210>  140
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR3

<400>  140
ggagtcccat caaggttcag tggcagtggg tctggaacag attattctct caccattagc       60

aacctggagc aagaagatat tgccacttac ttttgc                                 96


<210>  141
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR3

<400>  141
caacagggta atacgcttcc gtggacg                                           27


<210>  142
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain FR4

<400>  142
ttcggtggag gcaccaaact ggaaatcaaa                                        30


<210>  143
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  143

Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln Gly 
1               5                   10                  15      


Thr Arg Cys Asp Ile Gln Met Thr His Thr Thr Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  144
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  144

Asp Ile Gln Met Thr His Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  145
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain signal sequence

<400>  145

Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln Gly 
1               5                   10                  15      


Thr Arg Cys 
            


<210>  146
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR1

<400>  146

Asp Ile Gln Met Thr His Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  147
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR2

<400>  147

Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  148
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR3

<400>  148

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  149
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain CDR3

<400>  149

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  150
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AA Junction

<400>  150

Cys Ala Arg Ile Asp Tyr Gly Thr Ile His Thr Ser Trp Phe Ala Tyr 
1               5                   10                  15      


Trp 
    


<210>  151
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  151
atggaatgga gttggatatt tctctttctc ctgtcaggaa ctgcaggtgt ccactctgag       60

gtccagctgc agcagtctgg acctgagttg gtaaagcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggatacac attcactagt tctgttattc actgggtgaa gcagaagcct      180

gggcagggcc ttgagtggct tggatatatt aatccttata gtgatggaac taaattcaat      240

gagaagtgca aaatcaaggc cacactgact tcagacaaat cctccagcac agcctacatg      300

gaactcagca gcctgacctc tgaggactct gcggtctatt actgtgcaag aggccttata      360

gggactagat acgactcctg gtttgcttac tggggccaag ggactctggt cactgtctct      420

gca                                                                    423


<210>  152
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  152
gaggtccagc tgcagcagtc tggacctgag ttggtaaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggata cacattcact agttctgtta ttcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gcttggatat attaatcctt atagtgatgg aactaaattc      180

aatgagaagt gcaaaatcaa ggccacactg acttcagaca aatcctccag cacagcctac      240

atggaactca gcagcctgac ctctgaggac tctgcggtct attactgtgc aagaggcctt      300

atagggacta gatacgactc ctggtttgct tactggggcc aagggactct ggtcactgtc      360

tctgca                                                                 366


<210>  153
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR1

<400>  153
gaggtccagc tgcagcagtc tggacctgag ttggtaaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggata cacattcact                                        90


<210>  154
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR1

<400>  154
agttctgtta ttcac                                                        15


<210>  155
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR2

<400>  155
tgggtgaagc agaagcctgg gcagggcctt gagtggcttg ga                          42


<210>  156
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR2

<400>  156
tatattaatc cttatagtga tggaactaaa ttcaatgaga agtgcaaaat c                51


<210>  157
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR3

<400>  157
aaggccacac tgacttcaga caaatcctcc agcacagcct acatggaact cagcagcctg       60

acctctgagg actctgcggt ctattactgt gcaaga                                 96


<210>  158
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR3

<400>  158
ggccttatag ggactagata cgactcctgg tttgcttac                              39


<210>  159
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR4

<400>  159
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  160
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  160

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Ser Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn 
65                  70                  75                  80  


Glu Lys Cys Lys Ile Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140     


<210>  161
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  161

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn Glu Lys Cys 
    50                  55                  60                  


Lys Ile Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  162
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR1

<400>  162

Ser Ser Val Ile His 
1               5   


<210>  163
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR2

<400>  163

Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn Glu Lys Cys Lys 
1               5                   10                  15      


Ile 
    


<210>  164
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain 1 variable domain

<400>  164
atgtcctctg ctcagttcct tggtctcctg ttgctctgtt ttcaaggtat cagatgtgat       60

atccagatga cacagaatgg atcctccctg tctgcctctc tgggagacag agtcaccatc      120

agttgcagga caagtcagga cattaacaat tatttaaatt ggtatcagca gaaacaagat      180

ggaactgtta aactcctgat ctactacaca tcaagattac actcaggagt cccatcaagg      240

ttcagtggca gtgggtctgg aacagattat tctctcacca ttcgcaacct ggagcaagaa      300

gatattgcca cttacttttg ccaacagggt aatacgcttc cgtacacgtt cggagggggg      360

accaaactgg aaataaaa                                                    378


<210>  165
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain 1 variable domain

<400>  165
gatatccaga tgacacagaa tggatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca ggacaagtca ggacattaac aattatttaa attggtatca gcagaaacaa      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattcgcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaaac tggaaataaa a                                                321


<210>  166
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain 1 FR1

<400>  166
gatatccaga tgacacagaa tggatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgc                                                               69


<210>  167
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain 1 FR2

<400>  167
tggtatcagc agaaacaaga tggaactgtt aaactcctga tctac                       45


<210>  168
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain 1 FR3

<400>  168
ggagtcccat caaggttcag tggcagtggg tctggaacag attattctct caccattcgc       60

aacctggagc aagaagatat tgccacttac ttttgc                                 96


<210>  169
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain 1 variable domain

<400>  169

Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln Gly 
1               5                   10                  15      


Ile Arg Cys Asp Ile Gln Met Thr Gln Asn Gly Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Thr Ser Gln Asp Ile 
        35                  40                  45              


Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Gln Asp Gly Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Arg Asn 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  170
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain 1 variable domain

<400>  170

Asp Ile Gln Met Thr Gln Asn Gly Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Thr Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Gln Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  171
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain 1 FR1

<400>  171

Asp Ile Gln Met Thr Gln Asn Gly Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  172
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain 1 FR2

<400>  172

Trp Tyr Gln Gln Lys Gln Asp Gly Thr Val Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  173
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain 1 FR3

<400>  173

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Arg Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  174
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain 2 variable domain

<400>  174
atgagggtcc ttgctgagct cctggggctg ctgctgttct gctttttagg tgtgagatgt       60

gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc      120

atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca      180

ggaaatattc ctaaactatt gatctataag gcttccaact tgcacacagg cgtcccatca      240

agatttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      300

gaagacattg ccacttacta ctgtcaacag ggtcaaagtt atcctctcac gttcggtgct      360

gggaccaagc tggagctgaa a                                                381


<210>  175
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain 2 variable domain

<400>  175
gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc       60

atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca      120

ggaaatattc ctaaactatt gatctataag gcttccaact tgcacacagg cgtcccatca      180

agatttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      240

gaagacattg ccacttacta ctgtcaacag ggtcaaagtt atcctctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  176
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain 2 CDR2

<400>  176
aaggcttcca acttgcacac a                                                 21


<210>  177
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain 2 FR3

<400>  177
ggcgtcccat caagatttag tggcagtgga tctggaacag gtttcacatt aaccatcagc       60

agcctgcagc ctgaagacat tgccacttac tactgt                                 96


<210>  178
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain 2 CDR3

<400>  178
caacagggtc aaagttatcc tctcacg                                           27


<210>  179
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain 2 FR4

<400>  179
ttcggtgctg ggaccaagct ggagctgaaa                                        30


<210>  180
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain 2 variable domain

<400>  180

Met Arg Val Leu Ala Glu Leu Leu Gly Leu Leu Leu Phe Cys Phe Leu 
1               5                   10                  15      


Gly Val Arg Cys Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn 
        35                  40                  45              


Ile Asn Val Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln 
            100                 105                 110         


Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  181
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain 2 variable domain

<400>  181

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  182
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain 2 CDR3

<400>  182

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  183
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain 2 FR4

<400>  183

Phe Gly Ala Gly Thr Lys Leu Glu Leu 
1               5                   


<210>  184
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AA Junction

<400>  184

Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe 
1               5                   10      


<210>  185
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AA Junction

<400>  185

Cys Ala Ser Gly Tyr Gly His Tyr Val Gly Ala Met Asp Tyr Trp 
1               5                   10                  15  


<210>  186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AA Junction

<400>  186

Cys Gln Gln Ser Arg Asn Tyr Pro Tyr Thr Phe 
1               5                   10      


<210>  187
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AA Junction

<400>  187

Cys Gln Gln Gly Gln Ser Tyr Pro Tyr Thr Phe 
1               5                   10      


<210>  188
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-chimeric-VH-PTM1

<400>  188

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Ser Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Tyr Ile Asn Pro Tyr Ser Glu Gly Thr Lys Phe Asn 
65                  70                  75                  80  


Glu Lys Ser Lys Ile Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210>  189
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-chimeric-VH-PTM2

<400>  189

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Ser Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Tyr Ile Asn Pro Tyr Ser Asp Ala Thr Lys Phe Asn 
65                  70                  75                  80  


Glu Lys Ser Lys Ile Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210>  190
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH1

<400>  190

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Ser Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn 
65                  70                  75                  80  


Glu Lys Cys Lys Ile Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210>  191
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH1-PTM

<400>  191

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Ser Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asn Pro Tyr Ser Glu Gly Thr Lys Phe Asn 
65                  70                  75                  80  


Glu Lys Ser Lys Ile Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210>  192
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH2

<400>  192

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Ser Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn 
65                  70                  75                  80  


Glu Lys Cys Lys Ile Arg Ala Thr Met Thr Ser Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210>  193
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH3

<400>  193

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Ser Val Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn 
65                  70                  75                  80  


Glu Lys Cys Lys Ile Arg Val Thr Leu Thr Ser Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210>  194
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH4

<400>  194

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Ser Val Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn 
65                  70                  75                  80  


Glu Lys Cys Lys Ile Arg Ala Thr Met Thr Ser Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210>  195
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-chimeric-VH-PTM1

<400>  195
atgggctggt cttgtattat tctgtttctg gtcgcaactg ctacaggcgt gcattctgaa       60

gtgcagctgc agcagagcgg cccagagctc gtcaaacctg gagccagcgt gaagctgagc      120

tgtaaagctt ctggatacac ctttaccagc tctgtgatcc actgggtgaa gcagaagcct      180

ggccagggcc tggaatggct gggctacatc aacccctaca gcgagggcac aaagttcaac      240

gagaagtcca agatcaaggc caccctgacc tccgataaga gcagcagcac cgcctatatg      300

gaactgagca gcctgacatc tgaggacagc gccgtgtact actgcgcccg gggcctgatc      360

ggcacaagat acgactcttg gttcgcctac tggggacaag gcaccctggt gaccgtgtcc      420

gctgccagca ccaagggccc ttccgtgttt cccctggccc cttgctcccg gtccacatct      480

gagagcaccg ccgccctggg ctgtctggtg aaggactact tcccagagcc cgtgaccgtg      540

agctggaaca gcggcgccct gacaagcggc gtgcacacat ttcccgccgt gctgcagagc      600

tccggcctgt actccctgtc tagcgtggtg acagtgcctt cctctagcct gggcaccaag      660

acatatacct gtaacgtgga ccacaagcca agcaatacca aggtggataa gcgggtggag      720

tctaagtacg gccctccttg ccctccatgt cctgctccag agtttctggg cggcccttcc      780

gtgttcctgt ttccacccaa accaaaggac acactgatga tctctagaac accagaggtg      840

acctgcgtgg tggtggacgt gagccaggag gatcccgagg tgcagttcaa ctggtacgtg      900

gatggcgtgg aggtgcacaa tgccaagacc aagccaagag aggagcagtt taactctaca      960

tacagggtgg tgagcgtgct gaccgtgctg caccaggatt ggctcaacgg caaggagtat     1020

aagtgcaagg tgtccaataa gggcctgccc tcctctatcg agaagacaat ctctaaggct     1080

aagggccagc caagagagcc tcaggtgtac accctgcctc caagccagga ggagatgaca     1140

aagaaccagg tgtccctgac atgtctggtg aagggcttct atccctccga catcgccgtg     1200

gagtgggagt ctaatggcca gcctgagaac aattacaaga ccacaccccc tgtgctggac     1260

tctgatggca gcttctttct gtattccagg ctgaccgtgg ataagtctcg gtggcaggag     1320

ggcaacgtgt tcagctgctc tgtgatgcac gaagccctgc ataatcacta tactcagaaa     1380

agtctgtcac tgtcactggg aaagtgataa                                      1410


<210>  196
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-chimeric-VH-PTM2

<400>  196
atgggctggt cttgtattat tctgtttctg gtcgcaactg ctacaggcgt gcattctgag       60

gtgcagctgc agcagagcgg acctgagctg gtgaagccag gcgccagcgt gaaactgagc      120

tgtaaagctt ctggctacac cttcaccagc tctgtgatcc actgggtcaa gcagaagcct      180

ggacaaggcc tggaatggct gggctacatc aacccctaca gcgacgccac caagttcaac      240

gagaagagca agatcaaggc cacactgacc tctgataagt ccagctccac cgcctacatg      300

gaactgtcta gcctgacaag cgaggacagc gccgtgtact actgcgccag aggcctcatc      360

ggcacccggt acgacagctg gtttgcctat tggggccagg gcacactggt tacagtgtcc      420

gctgccagca ccaagggccc ttccgtgttt cccctggccc cttgctcccg gtccacatct      480

gagagcaccg ccgccctggg ctgtctggtg aaggactact tcccagagcc cgtgaccgtg      540

agctggaaca gcggcgccct gacaagcggc gtgcacacat ttcccgccgt gctgcagagc      600

tccggcctgt actccctgtc tagcgtggtg acagtgcctt cctctagcct gggcaccaag      660

acatatacct gtaacgtgga ccacaagcca agcaatacca aggtggataa gcgggtggag      720

tctaagtacg gccctccttg ccctccatgt cctgctccag agtttctggg cggcccttcc      780

gtgttcctgt ttccacccaa accaaaggac acactgatga tctctagaac accagaggtg      840

acctgcgtgg tggtggacgt gagccaggag gatcccgagg tgcagttcaa ctggtacgtg      900

gatggcgtgg aggtgcacaa tgccaagacc aagccaagag aggagcagtt taactctaca      960

tacagggtgg tgagcgtgct gaccgtgctg caccaggatt ggctcaacgg caaggagtat     1020

aagtgcaagg tgtccaataa gggcctgccc tcctctatcg agaagacaat ctctaaggct     1080

aagggccagc caagagagcc tcaggtgtac accctgcctc caagccagga ggagatgaca     1140

aagaaccagg tgtccctgac atgtctggtg aagggcttct atccctccga catcgccgtg     1200

gagtgggagt ctaatggcca gcctgagaac aattacaaga ccacaccccc tgtgctggac     1260

tctgatggca gcttctttct gtattccagg ctgaccgtgg ataagtctcg gtggcaggag     1320

ggcaacgtgt tcagctgctc tgtgatgcac gaagccctgc ataatcacta tactcagaaa     1380

agtctgtcac tgtcactggg aaagtgataa                                      1410


<210>  197
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH1

<400>  197
atgggctggt cttgtattat tctgtttctg gtcgcaactg ctacaggcgt gcattctcaa       60

gtgcagctgg ttcagagcgg cgccgaggtg aagaaacctg gagcttccgt gaaagtgtcc      120

tgcaaggcct ctggctacac cttcaccagc agcgtgatcc actgggtgcg gcaggcccct      180

ggccagggcc tggaatggat gggctacatc aacccctaca gcgatggcac aaagttcaac      240

gagaagtgca agatccgggt gaccatgacc agagatacat ctatcagcac cgcttatatg      300

gaactgagca gactgagaag cgacgacacc gccgtgtact actgtgccag aggcctgatc      360

ggcacacgct acgacagctg gtttgcctac tggggccagg gaacactggt caccgtgtct      420

agcgccagca ccaagggccc ttccgtgttt cccctggccc cttgctcccg gtccacatct      480

gagagcaccg ccgccctggg ctgtctggtg aaggactact tcccagagcc cgtgaccgtg      540

agctggaaca gcggcgccct gacaagcggc gtgcacacat ttcccgccgt gctgcagagc      600

tccggcctgt actccctgtc tagcgtggtg acagtgcctt cctctagcct gggcaccaag      660

acatatacct gtaacgtgga ccacaagcca agcaatacca aggtggataa gcgggtggag      720

tctaagtacg gccctccttg ccctccatgt cctgctccag agtttctggg cggcccttcc      780

gtgttcctgt ttccacccaa accaaaggac acactgatga tctctagaac accagaggtg      840

acctgcgtgg tggtggacgt gagccaggag gatcccgagg tgcagttcaa ctggtacgtg      900

gatggcgtgg aggtgcacaa tgccaagacc aagccaagag aggagcagtt taactctaca      960

tacagggtgg tgagcgtgct gaccgtgctg caccaggatt ggctcaacgg caaggagtat     1020

aagtgcaagg tgtccaataa gggcctgccc tcctctatcg agaagacaat ctctaaggct     1080

aagggccagc caagagagcc tcaggtgtac accctgcctc caagccagga ggagatgaca     1140

aagaaccagg tgtccctgac atgtctggtg aagggcttct atccctccga catcgccgtg     1200

gagtgggagt ctaatggcca gcctgagaac aattacaaga ccacaccccc tgtgctggac     1260

tctgatggca gcttctttct gtattccagg ctgaccgtgg ataagtctcg gtggcaggag     1320

ggcaacgtgt tcagctgctc tgtgatgcac gaagccctgc ataatcacta tactcagaaa     1380

agtctgtcac tgtcactggg aaagtgataa                                      1410


<210>  198
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH1-PTM

<400>  198
atgggctggt cttgtattat tctgtttctg gtcgcaactg ctacaggcgt gcattctcaa       60

gtgcagctgg tccagagcgg cgccgaggtg aaaaagcctg gcgcttctgt gaaggtgtcc      120

tgcaaggcct ctggctacac cttcaccagc agcgtgatcc actgggtgcg gcaggcccct      180

ggacagggcc tggaatggat gggctacatc aacccctaca gcgagggcac aaagttcaac      240

gagaaaagca agatcagagt gaccatgacc agagatacct ccatcagcac agcttacatg      300

gaactgagcc gcctgcggag cgacgacacc gccgtgtact actgtgccag aggcctgatc      360

ggcacaagat acgacagctg gtttgcctat tggggccagg gaaccctggt tacagtgtct      420

agcgccagca ccaagggccc ttccgtgttt cccctggccc cttgctcccg gtccacatct      480

gagagcaccg ccgccctggg ctgtctggtg aaggactact tcccagagcc cgtgaccgtg      540

agctggaaca gcggcgccct gacaagcggc gtgcacacat ttcccgccgt gctgcagagc      600

tccggcctgt actccctgtc tagcgtggtg acagtgcctt cctctagcct gggcaccaag      660

acatatacct gtaacgtgga ccacaagcca agcaatacca aggtggataa gcgggtggag      720

tctaagtacg gccctccttg ccctccatgt cctgctccag agtttctggg cggcccttcc      780

gtgttcctgt ttccacccaa accaaaggac acactgatga tctctagaac accagaggtg      840

acctgcgtgg tggtggacgt gagccaggag gatcccgagg tgcagttcaa ctggtacgtg      900

gatggcgtgg aggtgcacaa tgccaagacc aagccaagag aggagcagtt taactctaca      960

tacagggtgg tgagcgtgct gaccgtgctg caccaggatt ggctcaacgg caaggagtat     1020

aagtgcaagg tgtccaataa gggcctgccc tcctctatcg agaagacaat ctctaaggct     1080

aagggccagc caagagagcc tcaggtgtac accctgcctc caagccagga ggagatgaca     1140

aagaaccagg tgtccctgac atgtctggtg aagggcttct atccctccga catcgccgtg     1200

gagtgggagt ctaatggcca gcctgagaac aattacaaga ccacaccccc tgtgctggac     1260

tctgatggca gcttctttct gtattccagg ctgaccgtgg ataagtctcg gtggcaggag     1320

ggcaacgtgt tcagctgctc tgtgatgcac gaagccctgc ataatcacta tactcagaaa     1380

agtctgtcac tgtcactggg aaagtgataa                                      1410


<210>  199
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH2

<400>  199
atgggctggt cttgtattat tctgtttctg gtcgcaactg ctacaggcgt gcattctcaa       60

gtgcagctgg tccagagcgg cgccgaggtg aagaagcctg gcgcttctgt gaaagtgtct      120

tgtaaagcct ctggatacac cttcaccagc agcgtgatcc actgggtgcg gcaggcccct      180

ggacagggcc tggaatggct gggctacatc aacccctaca gcgatggcac aaagttcaac      240

gagaagtgca agatccgggc cacaatgacc tccgatacaa gcatcagcac cgcttatatg      300

gaactgagca gactgagaag cgacgacacc gccgtgtact actgcgccag aggcctgatc      360

ggcacaagat acgacagctg gtttgcctac tggggccagg gcaccctggt gaccgtgtcc      420

agcgccagca ccaagggccc ttccgtgttt cccctggccc cttgctcccg gtccacatct      480

gagagcaccg ccgccctggg ctgtctggtg aaggactact tcccagagcc cgtgaccgtg      540

agctggaaca gcggcgccct gacaagcggc gtgcacacat ttcccgccgt gctgcagagc      600

tccggcctgt actccctgtc tagcgtggtg acagtgcctt cctctagcct gggcaccaag      660

acatatacct gtaacgtgga ccacaagcca agcaatacca aggtggataa gcgggtggag      720

tctaagtacg gccctccttg ccctccatgt cctgctccag agtttctggg cggcccttcc      780

gtgttcctgt ttccacccaa accaaaggac acactgatga tctctagaac accagaggtg      840

acctgcgtgg tggtggacgt gagccaggag gatcccgagg tgcagttcaa ctggtacgtg      900

gatggcgtgg aggtgcacaa tgccaagacc aagccaagag aggagcagtt taactctaca      960

tacagggtgg tgagcgtgct gaccgtgctg caccaggatt ggctcaacgg caaggagtat     1020

aagtgcaagg tgtccaataa gggcctgccc tcctctatcg agaagacaat ctctaaggct     1080

aagggccagc caagagagcc tcaggtgtac accctgcctc caagccagga ggagatgaca     1140

aagaaccagg tgtccctgac atgtctggtg aagggcttct atccctccga catcgccgtg     1200

gagtgggagt ctaatggcca gcctgagaac aattacaaga ccacaccccc tgtgctggac     1260

tctgatggca gcttctttct gtattccagg ctgaccgtgg ataagtctcg gtggcaggag     1320

ggcaacgtgt tcagctgctc tgtgatgcac gaagccctgc ataatcacta tactcagaaa     1380

agtctgtcac tgtcactggg aaagtgataa                                      1410


<210>  200
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH3

<400>  200
atgggctggt cttgtattat tctgtttctg gtcgcaactg ctacaggcgt gcattctcaa       60

gtgcagctcg tgcagagcgg cgccgaggtg aaaaagcctg gcgcttctgt gaaggtgtct      120

tgtaaagcct ctggctacac cttcaccagc agcgtgatcc actgggttaa gcaggcccct      180

ggacagggcc tggaatggct gggctacatc aacccctaca gcgatggcac aaagttcaac      240

gagaagtgca agatccgggt gaccctgacc tccgatacaa gcatcagcac cgcttatatg      300

gaactgagca gactgcggag cgacgacacc gccgtgtact actgcgccag aggcctgatc      360

ggaacaagat acgacagctg gtttgcctac tggggccagg gcacactggt caccgtgtcc      420

agcgccagca ccaagggccc ttccgtgttt cccctggccc cttgctcccg gtccacatct      480

gagagcaccg ccgccctggg ctgtctggtg aaggactact tcccagagcc cgtgaccgtg      540

agctggaaca gcggcgccct gacaagcggc gtgcacacat ttcccgccgt gctgcagagc      600

tccggcctgt actccctgtc tagcgtggtg acagtgcctt cctctagcct gggcaccaag      660

acatatacct gtaacgtgga ccacaagcca agcaatacca aggtggataa gcgggtggag      720

tctaagtacg gccctccttg ccctccatgt cctgctccag agtttctggg cggcccttcc      780

gtgttcctgt ttccacccaa accaaaggac acactgatga tctctagaac accagaggtg      840

acctgcgtgg tggtggacgt gagccaggag gatcccgagg tgcagttcaa ctggtacgtg      900

gatggcgtgg aggtgcacaa tgccaagacc aagccaagag aggagcagtt taactctaca      960

tacagggtgg tgagcgtgct gaccgtgctg caccaggatt ggctcaacgg caaggagtat     1020

aagtgcaagg tgtccaataa gggcctgccc tcctctatcg agaagacaat ctctaaggct     1080

aagggccagc caagagagcc tcaggtgtac accctgcctc caagccagga ggagatgaca     1140

aagaaccagg tgtccctgac atgtctggtg aagggcttct atccctccga catcgccgtg     1200

gagtgggagt ctaatggcca gcctgagaac aattacaaga ccacaccccc tgtgctggac     1260

tctgatggca gcttctttct gtattccagg ctgaccgtgg ataagtctcg gtggcaggag     1320

ggcaacgtgt tcagctgctc tgtgatgcac gaagccctgc ataatcacta tactcagaaa     1380

agtctgtcac tgtcactggg aaagtgataa                                      1410


<210>  201
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH4

<400>  201
atgggctggt cttgtattat tctgtttctg gtcgcaactg ctacaggcgt gcattctcaa       60

gtgcagctgg ttcagagcgg cgccgaggtg aaaaagcctg gcgcttctgt gaaggtgtct      120

tgtaaagcct ctggctacac cttcaccagc agcgtgatcc actgggtcaa gcaggcccct      180

ggacagggac tggaatggct gggctacatc aacccctaca gcgatggcac aaagttcaac      240

gagaagtgca agatccgggc cacaatgacc tccgataaga gcatcagcac cgcttatatg      300

gaactgagca gactgcggag cgacgacacc gccgtgtact actgcgccag aggcctgatc      360

ggcacaagat acgacagctg gtttgcctac tggggccagg gcaccctggt gaccgtgtcc      420

agcgccagca ccaagggccc ttccgtgttt cccctggccc cttgctcccg gtccacatct      480

gagagcaccg ccgccctggg ctgtctggtg aaggactact tcccagagcc cgtgaccgtg      540

agctggaaca gcggcgccct gacaagcggc gtgcacacat ttcccgccgt gctgcagagc      600

tccggcctgt actccctgtc tagcgtggtg acagtgcctt cctctagcct gggcaccaag      660

acatatacct gtaacgtgga ccacaagcca agcaatacca aggtggataa gcgggtggag      720

tctaagtacg gccctccttg ccctccatgt cctgctccag agtttctggg cggcccttcc      780

gtgttcctgt ttccacccaa accaaaggac acactgatga tctctagaac accagaggtg      840

acctgcgtgg tggtggacgt gagccaggag gatcccgagg tgcagttcaa ctggtacgtg      900

gatggcgtgg aggtgcacaa tgccaagacc aagccaagag aggagcagtt taactctaca      960

tacagggtgg tgagcgtgct gaccgtgctg caccaggatt ggctcaacgg caaggagtat     1020

aagtgcaagg tgtccaataa gggcctgccc tcctctatcg agaagacaat ctctaaggct     1080

aagggccagc caagagagcc tcaggtgtac accctgcctc caagccagga ggagatgaca     1140

aagaaccagg tgtccctgac atgtctggtg aagggcttct atccctccga catcgccgtg     1200

gagtgggagt ctaatggcca gcctgagaac aattacaaga ccacaccccc tgtgctggac     1260

tctgatggca gcttctttct gtattccagg ctgaccgtgg ataagtctcg gtggcaggag     1320

ggcaacgtgt tcagctgctc tgtgatgcac gaagccctgc ataatcacta tactcagaaa     1380

agtctgtcac tgtcactggg aaagtgataa                                      1410


<210>  202
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VL1

<400>  202

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile 
        35                  40                  45              


Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  203
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VL2

<400>  203

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile 
        35                  40                  45              


Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  204
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VL3

<400>  204

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile 
        35                  40                  45              


Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  205
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VL4

<400>  205

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg Thr Ser Gln Asp Ile 
        35                  40                  45              


Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  206
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VL1

<400>  206
atgggctggt catgtattat tctgtttctg gtcgcaactg ctacaggggt ccatagtgat       60

attcagatga cacagagccc ctcttctctg agcgctagcg tgggcgatag agtgaccatc      120

acatgtagaa cctcccagga catcaacaac tacctgaact ggtaccagca gaaaccaggc      180

aaggccccta agctgctgat ctactacacc agccggctgc acagcggcgt ccccagcaga      240

ttcagcggct ccggatctgg caccgacttc acctttacca tcagcagcct gcagcctgag      300

gacatcgcca cctactactg ccagcaaggc aataccctgc cttatacatt cggcggcgga      360

acaaaggtgg aaatcaagag gacagtggcc gccccaagcg tgttcatctt tcccccttcc      420

gacgagcagc tgaagtctgg caccgccagc gtggtgtgcc tgctgaacaa cttctaccct      480

cgggaggcca aggtccagtg gaaggtggat aacgccctgc agtctggcaa tagccaggag      540

tccgtgaccg agcaggactc taaggatagc acatattccc tgtctagcac cctgacactg      600

agcaaggccg attacgagaa gcacaaggtg tatgcctgtg aagtcaccca tcaggggctg      660

tcatcacccg tcactaagtc attcaatcgc ggagaatgct gataa                      705


<210>  207
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VL2

<400>  207
atgggctggt catgtattat tctgtttctg gtcgcaactg ctacaggggt ccatagtgat       60

attcagatga cccagagccc ctcctccctg agcgcttctg tgggcgatag agtgaccatc      120

acctgtagaa caagccagga catcaacaac tacctgaact ggtaccagca gaaacctggc      180

aaggccgtca agctgctgat ctactacacc agccggctgc acagcggagt gccatctaga      240

ttcagcggct ctggcagcgg caccgacttc acctttacca tcagcagcct gcagcctgag      300

gacatcgcca catacttctg ccagcaaggc aataccctgc cttatacatt cggcggcgga      360

acaaaggtgg aaatcaagag gacagtggcc gccccaagcg tgttcatctt tcccccttcc      420

gacgagcagc tgaagtctgg caccgccagc gtggtgtgcc tgctgaacaa cttctaccct      480

cgggaggcca aggtccagtg gaaggtggat aacgccctgc agtctggcaa tagccaggag      540

tccgtgaccg agcaggactc taaggatagc acatattccc tgtctagcac cctgacactg      600

agcaaggccg attacgagaa gcacaaggtg tatgcctgtg aagtcaccca tcaggggctg      660

tcatcacccg tcactaagtc attcaatcgc ggagaatgct gataa                      705


<210>  208
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VL3

<400>  208
atgggctggt catgtattat tctgtttctg gtcgcaactg ctacaggggt ccatagtgat       60

attcagatga cccagtcccc atctagcctg agcgccagcg tgggcgatag agtgaccatc      120

acctgtagaa ccagccagga catcaacaac tacctgaact ggtatcagca gaaacctggc      180

aaggccgtga agctgctgat ctactacaca tctagactgc acagcggcgt ccccagccgg      240

ttcagcggat ctggcagcgg caccgactac acatttacca tcagctccct gcagcctgag      300

gacatcgcta catacttctg ccagcaaggc aataccctgc cttacacctt cggcggaggc      360

acaaaggtgg aaatcaagag gacagtggcc gccccaagcg tgttcatctt tcccccttcc      420

gacgagcagc tgaagtctgg caccgccagc gtggtgtgcc tgctgaacaa cttctaccct      480

cgggaggcca aggtccagtg gaaggtggat aacgccctgc agtctggcaa tagccaggag      540

tccgtgaccg agcaggactc taaggatagc acatattccc tgtctagcac cctgacactg      600

agcaaggccg attacgagaa gcacaaggtg tatgcctgtg aagtcaccca tcaggggctg      660

tcatcacccg tcactaagtc attcaatcgc ggagaatgct gataa                      705


<210>  209
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VL4

<400>  209
atgggctggt catgtattat tctgtttctg gtcgcaactg ctacaggggt ccatagtgat       60

attcagatga cccagtcccc atcttccctg agcgccagcg tgggcgatag agtgaccatc      120

tcttgtagaa caagccagga catcaacaac tacctgaact ggtatcagca gaaacctggc      180

aagaccgtga agctgctgat ctactacacc agccggctgc acagcggcgt ccccagcaga      240

ttcagcggat ctggcagcgg caccgactac acatttacca tcagcagcct gcagcctgag      300

gacatcgcca catacttctg ccagcaaggc aataccctgc cttacacctt cggcggaggc      360

acaaaggtgg aaatcaagag gacagtggcc gccccaagcg tgttcatctt tcccccttcc      420

gacgagcagc tgaagtctgg caccgccagc gtggtgtgcc tgctgaacaa cttctaccct      480

cgggaggcca aggtccagtg gaaggtggat aacgccctgc agtctggcaa tagccaggag      540

tccgtgaccg agcaggactc taaggatagc acatattccc tgtctagcac cctgacactg      600

agcaaggccg attacgagaa gcacaaggtg tatgcctgtg aagtcaccca tcaggggctg      660

tcatcacccg tcactaagtc attcaatcgc ggagaatgct gataa                      705


<210>  210
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  210
atgggctggt cttgtattat tctgtttctg gtcgcaactg ctacaggcgt gcattctcaa       60

gtgcagctgg tccagagcgg cgccgaggtg aaaaagcctg gcgcttctgt gaaggtgtcc      120

tgcaaggcct ctggctacac cttcaccagc agcgtgatcc actgggtgcg gcaggcccct      180

ggacagggcc tggaatggat gggctacatc aacccctaca gcgagggcac aaagttcaac      240

gagaaaagca agatcagagt gaccatgacc agagatacct ccatcagcac agcttacatg      300

gaactgagcc gcctgcggag cgacgacacc gccgtgtact actgtgccag aggcctgatc      360

ggcacaagat acgacagctg gtttgcctat tggggccagg gaaccctggt tacagtgtct      420

agc                                                                    423


<210>  211
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  211
caagtgcagc tggtccagag cggcgccgag gtgaaaaagc ctggcgcttc tgtgaaggtg       60

tcctgcaagg cctctggcta caccttcacc agcagcgtga tccactgggt gcggcaggcc      120

cctggacagg gcctggaatg gatgggctac atcaacccct acagcgaggg cacaaagttc      180

aacgagaaaa gcaagatcag agtgaccatg accagagata cctccatcag cacagcttac      240

atggaactga gccgcctgcg gagcgacgac accgccgtgt actactgtgc cagaggcctg      300

atcggcacaa gatacgacag ctggtttgcc tattggggcc agggaaccct ggttacagtg      360

tctagc                                                                 366


<210>  212
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  212

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Ser Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asn Pro Tyr Ser Glu Gly Thr Lys Phe Asn 
65                  70                  75                  80  


Glu Lys Ser Lys Ile Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140     


<210>  213
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain variable domain

<400>  213

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Ser Glu Gly Thr Lys Phe Asn Glu Lys Ser 
    50                  55                  60                  


Lys Ile Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  214
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR1

<400>  214

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  215
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR2

<400>  215

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  216
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain CDR2

<400>  216

Tyr Ile Asn Pro Tyr Ser Glu Gly Thr Lys Phe Asn Glu Lys Ser Lys 
1               5                   10                  15      


Ile 
    


<210>  217
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR3

<400>  217

Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  218
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Heavy chain FR4

<400>  218

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  219
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  219
atgggctggt catgtattat tctgtttctg gtcgcaactg ctacaggggt ccatagtgat       60

attcagatga cacagagccc ctcttctctg agcgctagcg tgggcgatag agtgaccatc      120

acatgtagaa cctcccagga catcaacaac tacctgaact ggtaccagca gaaaccaggc      180

aaggccccta agctgctgat ctactacacc agccggctgc acagcggcgt ccccagcaga      240

ttcagcggct ccggatctgg caccgacttc acctttacca tcagcagcct gcagcctgag      300

gacatcgcca cctactactg ccagcaaggc aataccctgc cttatacatt cggcggcgga      360

acaaaggtgg aaatcaag                                                    378


<210>  220
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  220
gatattcaga tgacacagag cccctcttct ctgagcgcta gcgtgggcga tagagtgacc       60

atcacatgta gaacctccca ggacatcaac aactacctga actggtacca gcagaaacca      120

ggcaaggccc ctaagctgct gatctactac accagccggc tgcacagcgg cgtccccagc      180

agattcagcg gctccggatc tggcaccgac ttcaccttta ccatcagcag cctgcagcct      240

gaggacatcg ccacctacta ctgccagcaa ggcaataccc tgccttatac attcggcggc      300

ggaacaaagg tggaaatcaa g                                                321


<210>  221
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  221

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile 
        35                  40                  45              


Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125     


<210>  222
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  222

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  223
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR1

<400>  223

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  224
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR2

<400>  224

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  225
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR3

<400>  225

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  226
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR4

<400>  226

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  227
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  227
atgggctggt catgtattat tctgtttctg gtcgcaactg ctacaggggt ccatagtgat       60

attcagatga cccagagccc ctcctccctg agcgcttctg tgggcgatag agtgaccatc      120

acctgtagaa caagccagga catcaacaac tacctgaact ggtaccagca gaaacctggc      180

aaggccgtca agctgctgat ctactacacc agccggctgc acagcggagt gccatctaga      240

ttcagcggct ctggcagcgg caccgacttc acctttacca tcagcagcct gcagcctgag      300

gacatcgcca catacttctg ccagcaaggc aataccctgc cttatacatt cggcggcgga      360

acaaaggtgg aaatcaag                                                    378


<210>  228
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  228
gatattcaga tgacccagag cccctcctcc ctgagcgctt ctgtgggcga tagagtgacc       60

atcacctgta gaacaagcca ggacatcaac aactacctga actggtacca gcagaaacct      120

ggcaaggccg tcaagctgct gatctactac accagccggc tgcacagcgg agtgccatct      180

agattcagcg gctctggcag cggcaccgac ttcaccttta ccatcagcag cctgcagcct      240

gaggacatcg ccacatactt ctgccagcaa ggcaataccc tgccttatac attcggcggc      300

ggaacaaagg tggaaatcaa g                                                321


<210>  229
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  229

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile 
        35                  40                  45              


Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125     


<210>  230
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  230

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  231
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR2

<400>  231

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  232
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR3

<400>  232

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  233
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  233
atgggctggt catgtattat tctgtttctg gtcgcaactg ctacaggggt ccatagtgat       60

attcagatga cccagtcccc atctagcctg agcgccagcg tgggcgatag agtgaccatc      120

acctgtagaa ccagccagga catcaacaac tacctgaact ggtatcagca gaaacctggc      180

aaggccgtga agctgctgat ctactacaca tctagactgc acagcggcgt ccccagccgg      240

ttcagcggat ctggcagcgg caccgactac acatttacca tcagctccct gcagcctgag      300

gacatcgcta catacttctg ccagcaaggc aataccctgc cttacacctt cggcggaggc      360

acaaaggtgg aaatcaag                                                    378


<210>  234
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  234
gatattcaga tgacccagtc cccatctagc ctgagcgcca gcgtgggcga tagagtgacc       60

atcacctgta gaaccagcca ggacatcaac aactacctga actggtatca gcagaaacct      120

ggcaaggccg tgaagctgct gatctactac acatctagac tgcacagcgg cgtccccagc      180

cggttcagcg gatctggcag cggcaccgac tacacattta ccatcagctc cctgcagcct      240

gaggacatcg ctacatactt ctgccagcaa ggcaataccc tgccttacac cttcggcgga      300

ggcacaaagg tggaaatcaa g                                                321


<210>  235
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  235

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile 
        35                  40                  45              


Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125     


<210>  236
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain variable domain

<400>  236

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  237
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Light chain FR3

<400>  237

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  238
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-chimeric-VH-PTM1

<400>  238

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Ser Glu Gly Thr Lys Phe Asn Glu Lys Ser 
    50                  55                  60                  


Lys Ile Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  239
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-chimeric-VH-PTM2

<400>  239

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Ser Asp Ala Thr Lys Phe Asn Glu Lys Ser 
    50                  55                  60                  


Lys Ile Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  240
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH1

<400>  240

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn Glu Lys Cys 
    50                  55                  60                  


Lys Ile Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  241
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH2

<400>  241

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn Glu Lys Cys 
    50                  55                  60                  


Lys Ile Arg Ala Thr Met Thr Ser Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  242
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH3

<400>  242

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn Glu Lys Cys 
    50                  55                  60                  


Lys Ile Arg Val Thr Leu Thr Ser Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  243
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VH4

<400>  243

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Phe Asn Glu Lys Cys 
    50                  55                  60                  


Lys Ile Arg Ala Thr Met Thr Ser Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Ile Gly Thr Arg Tyr Asp Ser Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  244
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  U0959FD090-VL4

<400>  244

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Thr Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


