                         SEQUENCE LISTING

<110>  University of Virginia Patent Foundation
       The University of Manchester
       Petri Jr., William A.
       Donlan, Alexandra N.
       Allen, Judith E.
       Sutherland, Tara Elaine
       Day, Anthony John
 
<120>  Hyaluronan is a Driver of COVID-19 Severity

<130>  3062/143 PCT

<150>  US 63/129,145
<151>  2020-12-22

<160>  45    

<170>  PatentIn version 3.3

<210>  1
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln 
    130                 135                 140                 


Phe Asn 
145     


<210>  2
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
1               5                   10                  15      


Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln 
            20                  25                  30          


Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
        35                  40                  45              


Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe Val 
    50                  55                  60                  


Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln Phe 
65                  70                  75                  80  


Asn 
    


<210>  3
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 
    50                  55                  60                  


Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 
                165                 170                 175     


Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 
225                 230                 235                 240 


Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 
                245                 250                 255     


Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 
            260                 265                 270         


Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu 
        275                 280                 285             


Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro 
    290                 295                 300                 


Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys 
305                 310                 315                 320 


Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile 
                325                 330                 335     


Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val 
            340                 345                 350         


Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 
        355                 360                 365             


Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 
    370                 375                 380                 


Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys 
385                 390                 395                 400 


Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 
                405                 410                 415     


Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
            420                 425         


<210>  4
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  5
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  6
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu 
1               5                   10                  15      


Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu 
            20                  25                  30          


Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val 
        35                  40                  45              


Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala 
    50                  55                  60                  


Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys 
65                  70                  75                  80  


Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn 
                85                  90                  95      


Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp 
            100                 105                 110         


Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Ser Leu Arg Ala Leu Arg Gln Met 
    130                 135     


<210>  7
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asn Ser Phe Ser Thr Ile Pro Pro Gly Glu Asp Ser Lys Asp Val 
1               5                   10                  15      


Ala Ala Pro His Arg Gln Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys 
            20                  25                  30          


Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr 
        35                  40                  45              


Cys Asn Lys Ser Asn Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu 
    50                  55                  60                  


Asn Asn Leu Asn Leu Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln 
65                  70                  75                  80  


Ser Gly Phe Asn Glu Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu 
                85                  90                  95      


Leu Glu Phe Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser 
            100                 105                 110         


Ser Glu Glu Gln Ala Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile 
        115                 120                 125             


Gln Phe Leu Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro 
    130                 135                 140                 


Asp Pro Thr Thr Asn Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn 
145                 150                 155                 160 


Gln Trp Leu Gln Asp Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys 
                165                 170                 175     


Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu Arg Gln Met 
            180                 185                 


<210>  8
<211>  1283
<212>  DNA
<213>  Homo sapiens

<400>  8
aagccaccca gcctatgcat ccgctcctca atcctctcct gttggcactg ggcctcatgg     60

cgcttttgtt gaccacggtc attgctctca cttgccttgg cggctttgcc tccccaggcc    120

ctgtgcctcc ctctacagcc ctcagggagc tcattgagga gctggtcaac atcacccaga    180

accagaaggc tccgctctgc aatggcagca tggtatggag catcaacctg acagctggca    240

tgtactgtgc agccctggaa tccctgatca acgtgtcagg ctgcagtgcc atcgagaaga    300

cccagaggat gctgagcgga ttctgcccgc acaaggtctc agctgggcag ttttccagct    360

tgcatgtccg agacaccaaa atcgaggtgg cccagtttgt aaaggacctg ctcttacatt    420

taaagaaact ttttcgcgag ggacagttca actgaaactt cgaaagcatc attatttgca    480

gagacaggac ctgactattg aagttgcaga ttcatttttc tttctgatgt caaaaatgtc    540

ttgggtaggc gggaaggagg gttagggagg ggtaaaattc cttagcttag acctcagcct    600

gtgctgcccg tcttcagcct agccgacctc agccttcccc ttgcccaggg ctcagcctgg    660

tgggcctcct ctgtccaggg ccctgagctc ggtggaccca gggatgacat gtccctacac    720

ccctcccctg ccctagagca cactgtagca ttacagtggg tgcccccctt gccagacatg    780

tggtgggaca gggacccact tcacacacag gcaactgagg cagacagcag ctcaggcaca    840

cttcttcttg gtcttattta ttattgtgtg ttatttaaat gagtgtgttt gtcaccgttg    900

gggattgggg aagactgtgg ctgctagcac ttggagccaa gggttcagag actcagggcc    960

ccagcactaa agcagtggac accaggagtc cctggtaata agtactgtgt acagaattct   1020

gctacctcac tggggtcctg gggcctcgga gcctcatccg aggcagggtc aggagagggg   1080

cagaacagcc gctcctgtct gccagccagc agccagctct cagccaacga gtaatttatt   1140

gtttttcctt gtatttaaat attaaatatg ttagcaaaga gttaatatat agaagggtac   1200

cttgaacact gggggagggg acattgaaca agttgtttca ttgactatca aactgaagcc   1260

agaaataaag ttggtgacag ata                                           1283


<210>  9
<211>  1275
<212>  DNA
<213>  Homo sapiens

<400>  9
acgcgcgggg gcgcccctgc ccaccgctcc cggcagggct tttggtggcc atgggggata     60

aggggcgttg actcacccgg gcggggctcc gggagttgca cagaccaagg ccctgtgcct    120

ccctctacag ccctcaggga gctcattgag gagctggtca acatcaccca gaaccagaag    180

gctccgctct gcaatggcag catggtatgg agcatcaacc tgacagctgg catgtactgt    240

gcagccctgg aatccctgat caacgtgtca ggctgcagtg ccatcgagaa gacccagagg    300

atgctgagcg gattctgccc gcacaaggtc tcagctgggc agttttccag cttgcatgtc    360

cgagacacca aaatcgaggt ggcccagttt gtaaaggacc tgctcttaca tttaaagaaa    420

ctttttcgcg agggacagtt caactgaaac ttcgaaagca tcattatttg cagagacagg    480

acctgactat tgaagttgca gattcatttt tctttctgat gtcaaaaatg tcttgggtag    540

gcgggaagga gggttaggga ggggtaaaat tccttagctt agacctcagc ctgtgctgcc    600

cgtcttcagc ctagccgacc tcagccttcc ccttgcccag ggctcagcct ggtgggcctc    660

ctctgtccag ggccctgagc tcggtggacc cagggatgac atgtccctac acccctcccc    720

tgccctagag cacactgtag cattacagtg ggtgcccccc ttgccagaca tgtggtggga    780

cagggaccca cttcacacac aggcaactga ggcagacagc agctcaggca cacttcttct    840

tggtcttatt tattattgtg tgttatttaa atgagtgtgt ttgtcaccgt tggggattgg    900

ggaagactgt ggctgctagc acttggagcc aagggttcag agactcaggg ccccagcact    960

aaagcagtgg acaccaggag tccctggtaa taagtactgt gtacagaatt ctgctacctc   1020

actggggtcc tggggcctcg gagcctcatc cgaggcaggg tcaggagagg ggcagaacag   1080

ccgctcctgt ctgccagcca gcagccagct ctcagccaac gagtaattta ttgtttttcc   1140

ttgtatttaa atattaaata tgttagcaaa gagttaatat atagaagggt accttgaaca   1200

ctgggggagg ggacattgaa caagttgttt cattgactat caaactgaag ccagaaataa   1260

agttggtgac agata                                                    1275


<210>  10
<211>  1454
<212>  DNA
<213>  Homo sapiens

<400>  10
acgcgcgggg gcgcccctgc ccaccgctcc cggcagggct tttggtggcc atgggggata     60

aggggcgttg actcacccgg gcggggctcc gggagttgca cagaccaagg caaatgccgt    120

ggcctctgct gtgggggttt ctggaggact tctaggaaaa cgagggaaga gcaggaaaag    180

gcgacatggc tgcaggggcc aagcccagga gccgccctcc acagcactca ttctgcagaa    240

gggaaatttg aggcccccag acggcagggg ttgatcctgc agagactggc cctgtgcctc    300

cctctacagc cctcagggag ctcattgagg agctggtcaa catcacccag aaccagaagg    360

ctccgctctg caatggcagc atggtatgga gcatcaacct gacagctggc atgtactgtg    420

cagccctgga atccctgatc aacgtgtcag gctgcagtgc catcgagaag acccagagga    480

tgctgagcgg attctgcccg cacaaggtct cagctgggca gttttccagc ttgcatgtcc    540

gagacaccaa aatcgaggtg gcccagtttg taaaggacct gctcttacat ttaaagaaac    600

tttttcgcga gggacagttc aactgaaact tcgaaagcat cattatttgc agagacagga    660

cctgactatt gaagttgcag attcattttt ctttctgatg tcaaaaatgt cttgggtagg    720

cgggaaggag ggttagggag gggtaaaatt ccttagctta gacctcagcc tgtgctgccc    780

gtcttcagcc tagccgacct cagccttccc cttgcccagg gctcagcctg gtgggcctcc    840

tctgtccagg gccctgagct cggtggaccc agggatgaca tgtccctaca cccctcccct    900

gccctagagc acactgtagc attacagtgg gtgcccccct tgccagacat gtggtgggac    960

agggacccac ttcacacaca ggcaactgag gcagacagca gctcaggcac acttcttctt   1020

ggtcttattt attattgtgt gttatttaaa tgagtgtgtt tgtcaccgtt ggggattggg   1080

gaagactgtg gctgctagca cttggagcca agggttcaga gactcagggc cccagcacta   1140

aagcagtgga caccaggagt ccctggtaat aagtactgtg tacagaattc tgctacctca   1200

ctggggtcct ggggcctcgg agcctcatcc gaggcagggt caggagaggg gcagaacagc   1260

cgctcctgtc tgccagccag cagccagctc tcagccaacg agtaatttat tgtttttcct   1320

tgtatttaaa tattaaatat gttagcaaag agttaatata tagaagggta ccttgaacac   1380

tgggggaggg gacattgaac aagttgtttc attgactatc aaactgaagc cagaaataaa   1440

gttggtgaca gata                                                     1454


<210>  11
<211>  1383
<212>  DNA
<213>  Homo sapiens

<400>  11
acgcgcgggg gcgcccctgc ccaccgctcc cggcagggct tttggtggcc atgggggata     60

aggggcgttg actcacccgg gcggggctcc gggagttgca cagaccaagg caaatgccgt    120

ggcctctgct gtgggggttt ctggaggact tctaggaaaa cgagggaaga gcaggaaaag    180

gcgacatggc tgcaggggcc aagcccagga gccgccctcc acagcactca ttctgcagaa    240

gggaaatttg aggcccccag acggcagggg ttgatcctgc agagactggc tccgctctgc    300

aatggcagca tggtatggag catcaacctg acagctggca tgtactgtgc agccctggaa    360

tccctgatca acgtgtcagg ctgcagtgcc atcgagaaga cccagaggat gctgagcgga    420

ttctgcccgc acaaggtctc agctgggcag ttttccagct tgcatgtccg agacaccaaa    480

atcgaggtgg cccagtttgt aaaggacctg ctcttacatt taaagaaact ttttcgcgag    540

ggacagttca actgaaactt cgaaagcatc attatttgca gagacaggac ctgactattg    600

aagttgcaga ttcatttttc tttctgatgt caaaaatgtc ttgggtaggc gggaaggagg    660

gttagggagg ggtaaaattc cttagcttag acctcagcct gtgctgcccg tcttcagcct    720

agccgacctc agccttcccc ttgcccaggg ctcagcctgg tgggcctcct ctgtccaggg    780

ccctgagctc ggtggaccca gggatgacat gtccctacac ccctcccctg ccctagagca    840

cactgtagca ttacagtggg tgcccccctt gccagacatg tggtgggaca gggacccact    900

tcacacacag gcaactgagg cagacagcag ctcaggcaca cttcttcttg gtcttattta    960

ttattgtgtg ttatttaaat gagtgtgttt gtcaccgttg gggattgggg aagactgtgg   1020

ctgctagcac ttggagccaa gggttcagag actcagggcc ccagcactaa agcagtggac   1080

accaggagtc cctggtaata agtactgtgt acagaattct gctacctcac tggggtcctg   1140

gggcctcgga gcctcatccg aggcagggtc aggagagggg cagaacagcc gctcctgtct   1200

gccagccagc agccagctct cagccaacga gtaatttatt gtttttcctt gtatttaaat   1260

attaaatatg ttagcaaaga gttaatatat agaagggtac cttgaacact gggggagggg   1320

acattgaaca agttgtttca ttgactatca aactgaagcc agaaataaag ttggtgacag   1380

ata                                                                 1383


<210>  12
<211>  3996
<212>  DNA
<213>  Homo sapiens

<400>  12
ccagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg gctctgcggg     60

ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc cgcgcctacg    120

gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg cacagtaata    180

tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta ttttagtcat    240

tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat agaagtaccc    300

ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga gagtgagaag    360

cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga gtctgctgtg    420

actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg gctccctgga    480

aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag cctggaaaaa    540

attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc ctttgatctg    600

accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt caaggataat    660

gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt gaaacctgat    720

cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca atgggagaat    780

ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa cagccaaact    840

gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga atttgagaga    900

aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac tttgaacaca    960

gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact ctggagtaat   1020

tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat aaccatgtta   1080

ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta cctaaaaagg   1140

ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa agaaatgttt   1200

ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga gaagcaaacc   1260

aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc tcagtgatgg   1320

agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt ctccatttgt   1380

tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa caggcagctc   1440

ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat aatgggcgct   1500

ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc ttcaaactag   1560

gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt tgtgacaact   1620

tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa ttttatttgt   1680

aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa gaacatgtag   1740

aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac catgtttgtg   1800

gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct gtaatcccag   1860

caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga ccagcctgac   1920

caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg tggtggcgcg   1980

tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa cctgggaggt   2040

ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac agagcaagac   2100

tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat attctggagt   2160

catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc agtgttggcc   2220

atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt caaagccatt   2280

ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt ttcaaccatg   2340

aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta ctgtgtcttt   2400

ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt acagtctatt   2460

tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt tttcagacct   2520

tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct tcccttcctt   2580

gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga cctggaggag   2640

cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat gactaattct   2700

tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc attttctaaa   2760

cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa aaaagaatag   2820

ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc tctgccataa   2880

atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa ggctctgttt   2940

atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac atatccgtat   3000

atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg agaggcattt   3060

cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa cttgagaact   3120

ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc tatttgcaat   3180

tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt gggtacaagt   3240

ggcaacctgc ttccatggcc gtgtagaagc atggtgccct ggcttctctg aggaagctgg   3300

ggttcatgac aatggcagat gtaaagttat tcttgaagtc agattgaggc tgggagacag   3360

ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg gttttcctgt   3420

ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca aaacccatgc   3480

ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg atgctgtgaa   3540

attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa gtgatctttt   3600

gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg aaaaggaagt   3660

tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg aggtgtctgt   3720

atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt tttaggtcta   3780

gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat ggtaattctt   3840

attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata tgtgaaacaa   3900

tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc ttataggaaa   3960

gcttgagtaa aataaatatt gtctttttgt atgtca                             3996


<210>  13
<211>  3624
<212>  DNA
<213>  Homo sapiens

<400>  13
acttcccgct tgggcgcccg gacggcgaat ggagcagggg cgcgcagata attaaagatt     60

tacacacagc tggaagaaat catagagaag ccgggcgtgg tggctcatgc ctataatccc    120

agcacttttg gaggctgagg cgggcagatc acttgagatc aggagttcga gaccagcctg    180

gtgccttggc atctcccaat ggggtggctt tgctctgggc tcctgttccc tgtgagctgc    240

ctggtcctgc tgcaggtggc aagctctggg aacatgaagg tcttgcagga gcccacctgc    300

gtctccgact acatgagcat ctctacttgc gagtggaaga tgaatggtcc caccaattgc    360

agcaccgagc tccgcctgtt gtaccagctg gtttttctgc tctccgaagc ccacacgtgt    420

atccctgaga acaacggagg cgcggggtgc gtgtgccacc tgctcatgga tgacgtggtc    480

agtgcggata actatacact ggacctgtgg gctgggcagc agctgctgtg gaagggctcc    540

ttcaagccca gcgagcatgt gaaacccagg gccccaggaa acctgacagt tcacaccaat    600

gtctccgaca ctctgctgct gacctggagc aacccgtatc cccctgacaa ttacctgtat    660

aatcatctca cctatgcagt caacatttgg agtgaaaacg acccggcaga tttcagaatc    720

tataacgtga cctacctaga accctccctc cgcatcgcag ccagcaccct gaagtctggg    780

atttcctaca gggcacgggt gagggcctgg gctcagtgct ataacaccac ctggagtgag    840

tggagcccca gcaccaagtg gcacaactcc tacagggagc ccttcgagca gcacctcctg    900

ctgggcgtca gcgtttcctg cattgtcatc ctggccgtct gcctgttgtg ctatgtcagc    960

atcaccaaga ttaagaaaga atggtgggat cagattccca acccagcccg cagccgcctc   1020

gtggctataa taatccagga tgctcagggg tcacagtggg agaagcggtc ccgaggccag   1080

gaaccagcca agtgcccaca ctggaagaat tgtcttacca agctcttgcc ctgttttctg   1140

gagcacaaca tgaaaaggga tgaagatcct cacaaggctg ccaaagagat gcctttccag   1200

ggctctggaa aatcagcatg gtgcccagtg gagatcagca agacagtcct ctggccagag   1260

agcatcagcg tggtgcgatg tgtggagttg tttgaggccc cggtggagtg tgaggaggag   1320

gaggaggtag aggaagaaaa agggagcttc tgtgcatcgc ctgagagcag cagggatgac   1380

ttccaggagg gaagggaggg cattgtggcc cggctaacag agagcctgtt cctggacctg   1440

ctcggagagg agaatggggg cttttgccag caggacatgg gggagtcatg ccttcttcca   1500

ccttcgggaa gtacgagtgc tcacatgccc tgggatgagt tcccaagtgc agggcccaag   1560

gaggcacctc cctggggcaa ggagcagcct ctccacctgg agccaagtcc tcctgccagc   1620

ccgacccaga gtccagacaa cctgacttgc acagagacgc ccctcgtcat cgcaggcaac   1680

cctgcttacc gcagcttcag caactccctg agccagtcac cgtgtcccag agagctgggt   1740

ccagacccac tgctggccag acacctggag gaagtagaac ccgagatgcc ctgtgtcccc   1800

cagctctctg agccaaccac tgtgccccaa cctgagccag aaacctggga gcagatcctc   1860

cgccgaaatg tcctccagca tggggcagct gcagcccccg tctcggcccc caccagtggc   1920

tatcaggagt ttgtacatgc ggtggagcag ggtggcaccc aggccagtgc ggtggtgggc   1980

ttgggtcccc caggagaggc tggttacaag gccttctcaa gcctgcttgc cagcagtgct   2040

gtgtccccag agaaatgtgg gtttggggct agcagtgggg aagaggggta taagcctttc   2100

caagacctca ttcctggctg ccctggggac cctgccccag tccctgtccc cttgttcacc   2160

tttggactgg acagggagcc acctcgcagt ccgcagagct cacatctccc aagcagctcc   2220

ccagagcacc tgggtctgga gccgggggaa aaggtagagg acatgccaaa gcccccactt   2280

ccccaggagc aggccacaga cccccttgtg gacagcctgg gcagtggcat tgtctactca   2340

gcccttacct gccacctgtg cggccacctg aaacagtgtc atggccagga ggatggtggc   2400

cagacccctg tcatggccag tccttgctgt ggctgctgct gtggagacag gtcctcgccc   2460

cctacaaccc ccctgagggc cccagacccc tctccaggtg gggttccact ggaggccagt   2520

ctgtgtccgg cctccctggc accctcgggc atctcagaga agagtaaatc ctcatcatcc   2580

ttccatcctg cccctggcaa tgctcagagc tcaagccaga cccccaaaat cgtgaacttt   2640

gtctccgtgg gacccacata catgagggtc tcttaggtgc atgtcctctt gttgctgagt   2700

ctgcagatga ggactagggc ttatccatgc ctgggaaatg ccacctcctg gaaggcagcc   2760

aggctggcag atttccaaaa gacttgaaga accatggtat gaaggtgatt ggccccactg   2820

acgttggcct aacactgggc tgcagagact ggaccccgcc cagcattggg ctgggctcgc   2880

cacatcccat gagagtagag ggcactgggt cgccgtgccc cacggcaggc ccctgcagga   2940

aaactgaggc ccttgggcac ctcgacttgt gaacgagttg ttggctgctc cctccacagc   3000

ttctgcagca gactgtccct gttgtaactg cccaaggcat gttttgccca ccagatcatg   3060

gcccacgtgg aggcccacct gcctctgtct cactgaacta gaagccgagc ctagaaacta   3120

acacagccat caagggaatg acttgggcgg ccttgggaaa tcgatgagaa attgaacttc   3180

agggagggtg gtcattgcct agaggtgctc attcatttaa cagagcttcc ttaggttgat   3240

gctggaggca gaatcccggc tgtcaagggg tgttcagtta aggggagcaa cagaggacat   3300

gaaaaattgc tatgactaaa gcagggacaa tttgctgcca aacacccatg cccagctgta   3360

tggctggggg ctcctcgtat gcatggaacc cccagaataa atatgctcag ccaccctgtg   3420

ggccgggcaa tccagacagc aggcataagg caccagttac cctgcatgtt ggcccagacc   3480

tcaggtgcta gggaaggcgg gaaccttggg ttgagtaatg ctcgtctgtg tgttttagtt   3540

tcatcacctg ttatctgtgt ttgctgagga gagtggaaca gaaggggtgg agttttgtat   3600

aaataaagtt tctttgtctc ttta                                          3624


<210>  14
<211>  3491
<212>  DNA
<213>  Homo sapiens

<400>  14
acttcccgct tgggcgcccg gacggcgaat ggagcagggg cgcgcaggtg ccttggcatc     60

tcccaatggg gtggctttgc tctgggctcc tgttccctgt gagctgcctg gtcctgctgc    120

aggtggcaag ctctgggaac atgaaggtct tgcaggagcc cacctgcgtc tccgactaca    180

tgagcatctc tacttgcgag tggaagatga atggtcccac caattgcagc accgagctcc    240

gcctgttgta ccagctggtt tttctgctct ccgaagccca cacgtgtatc cctgagaaca    300

acggaggcgc ggggtgcgtg tgccacctgc tcatggatga cgtggtcagt gcggataact    360

atacactgga cctgtgggct gggcagcagc tgctgtggaa gggctccttc aagcccagcg    420

agcatgtgaa acccagggcc ccaggaaacc tgacagttca caccaatgtc tccgacactc    480

tgctgctgac ctggagcaac ccgtatcccc ctgacaatta cctgtataat catctcacct    540

atgcagtcaa catttggagt gaaaacgacc cggcagattt cagaatctat aacgtgacct    600

acctagaacc ctccctccgc atcgcagcca gcaccctgaa gtctgggatt tcctacaggg    660

cacgggtgag ggcctgggct cagtgctata acaccacctg gagtgagtgg agccccagca    720

ccaagtggca caactcctac agggagccct tcgagcagca cctcctgctg ggcgtcagcg    780

tttcctgcat tgtcatcctg gccgtctgcc tgttgtgcta tgtcagcatc accaagatta    840

agaaagaatg gtgggatcag attcccaacc cagcccgcag ccgcctcgtg gctataataa    900

tccaggatgc tcaggggtca cagtgggaga agcggtcccg aggccaggaa ccagccaagt    960

gcccacactg gaagaattgt cttaccaagc tcttgccctg ttttctggag cacaacatga   1020

aaagggatga agatcctcac aaggctgcca aagagatgcc tttccagggc tctggaaaat   1080

cagcatggtg cccagtggag atcagcaaga cagtcctctg gccagagagc atcagcgtgg   1140

tgcgatgtgt ggagttgttt gaggccccgg tggagtgtga ggaggaggag gaggtagagg   1200

aagaaaaagg gagcttctgt gcatcgcctg agagcagcag ggatgacttc caggagggaa   1260

gggagggcat tgtggcccgg ctaacagaga gcctgttcct ggacctgctc ggagaggaga   1320

atgggggctt ttgccagcag gacatggggg agtcatgcct tcttccacct tcgggaagta   1380

cgagtgctca catgccctgg gatgagttcc caagtgcagg gcccaaggag gcacctccct   1440

ggggcaagga gcagcctctc cacctggagc caagtcctcc tgccagcccg acccagagtc   1500

cagacaacct gacttgcaca gagacgcccc tcgtcatcgc aggcaaccct gcttaccgca   1560

gcttcagcaa ctccctgagc cagtcaccgt gtcccagaga gctgggtcca gacccactgc   1620

tggccagaca cctggaggaa gtagaacccg agatgccctg tgtcccccag ctctctgagc   1680

caaccactgt gccccaacct gagccagaaa cctgggagca gatcctccgc cgaaatgtcc   1740

tccagcatgg ggcagctgca gcccccgtct cggcccccac cagtggctat caggagtttg   1800

tacatgcggt ggagcagggt ggcacccagg ccagtgcggt ggtgggcttg ggtcccccag   1860

gagaggctgg ttacaaggcc ttctcaagcc tgcttgccag cagtgctgtg tccccagaga   1920

aatgtgggtt tggggctagc agtggggaag aggggtataa gcctttccaa gacctcattc   1980

ctggctgccc tggggaccct gccccagtcc ctgtcccctt gttcaccttt ggactggaca   2040

gggagccacc tcgcagtccg cagagctcac atctcccaag cagctcccca gagcacctgg   2100

gtctggagcc gggggaaaag gtagaggaca tgccaaagcc cccacttccc caggagcagg   2160

ccacagaccc ccttgtggac agcctgggca gtggcattgt ctactcagcc cttacctgcc   2220

acctgtgcgg ccacctgaaa cagtgtcatg gccaggagga tggtggccag acccctgtca   2280

tggccagtcc ttgctgtggc tgctgctgtg gagacaggtc ctcgccccct acaacccccc   2340

tgagggcccc agacccctct ccaggtgggg ttccactgga ggccagtctg tgtccggcct   2400

ccctggcacc ctcgggcatc tcagagaaga gtaaatcctc atcatccttc catcctgccc   2460

ctggcaatgc tcagagctca agccagaccc ccaaaatcgt gaactttgtc tccgtgggac   2520

ccacatacat gagggtctct taggtgcatg tcctcttgtt gctgagtctg cagatgagga   2580

ctagggctta tccatgcctg ggaaatgcca cctcctggaa ggcagccagg ctggcagatt   2640

tccaaaagac ttgaagaacc atggtatgaa ggtgattggc cccactgacg ttggcctaac   2700

actgggctgc agagactgga ccccgcccag cattgggctg ggctcgccac atcccatgag   2760

agtagagggc actgggtcgc cgtgccccac ggcaggcccc tgcaggaaaa ctgaggccct   2820

tgggcacctc gacttgtgaa cgagttgttg gctgctccct ccacagcttc tgcagcagac   2880

tgtccctgtt gtaactgccc aaggcatgtt ttgcccacca gatcatggcc cacgtggagg   2940

cccacctgcc tctgtctcac tgaactagaa gccgagccta gaaactaaca cagccatcaa   3000

gggaatgact tgggcggcct tgggaaatcg atgagaaatt gaacttcagg gagggtggtc   3060

attgcctaga ggtgctcatt catttaacag agcttcctta ggttgatgct ggaggcagaa   3120

tcccggctgt caaggggtgt tcagttaagg ggagcaacag aggacatgaa aaattgctat   3180

gactaaagca gggacaattt gctgccaaac acccatgccc agctgtatgg ctgggggctc   3240

ctcgtatgca tggaaccccc agaataaata tgctcagcca ccctgtgggc cgggcaatcc   3300

agacagcagg cataaggcac cagttaccct gcatgttggc ccagacctca ggtgctaggg   3360

aaggcgggaa ccttgggttg agtaatgctc gtctgtgtgt tttagtttca tcacctgtta   3420

tctgtgtttg ctgaggagag tggaacagaa ggggtggagt tttgtataaa taaagtttct   3480

ttgtctcttt a                                                        3491


<210>  15
<211>  3735
<212>  DNA
<213>  Homo sapiens

<400>  15
acttcccgct tgggcgcccg gacggcgaat ggagcagggg cgcgcaggtg ccttggcatc     60

tcccaatggg gtggctttgc tctgggctcc tgttccctgt gagctgcctg gtcctgctgc    120

aggtggcaag ctctggactc ttcaggatgc cgtgtggaga aaggaagagg gtggaagcca    180

ggaggtctgg agggaggtct ggagtggagg agatgagagg ctccggatcc ctctgggagg    240

tagatttgag gacagattgg aattgaggtg aaagacagag aaagagaagt ggccaggatg    300

actccaagat ttctgaccta aactactggg aaggacgcgg ttgtcatttc tgaaatgcag    360

aaggatgcca gaagagaagg gaacatgaag gtcttgcagg agcccacctg cgtctccgac    420

tacatgagca tctctacttg cgagtggaag atgaatggtc ccaccaattg cagcaccgag    480

ctccgcctgt tgtaccagct ggtttttctg ctctccgaag cccacacgtg tatccctgag    540

aacaacggag gcgcggggtg cgtgtgccac ctgctcatgg atgacgtggt cagtgcggat    600

aactatacac tggacctgtg ggctgggcag cagctgctgt ggaagggctc cttcaagccc    660

agcgagcatg tgaaacccag ggccccagga aacctgacag ttcacaccaa tgtctccgac    720

actctgctgc tgacctggag caacccgtat ccccctgaca attacctgta taatcatctc    780

acctatgcag tcaacatttg gagtgaaaac gacccggcag atttcagaat ctataacgtg    840

acctacctag aaccctccct ccgcatcgca gccagcaccc tgaagtctgg gatttcctac    900

agggcacggg tgagggcctg ggctcagtgc tataacacca cctggagtga gtggagcccc    960

agcaccaagt ggcacaactc ctacagggag cccttcgagc agcacctcct gctgggcgtc   1020

agcgtttcct gcattgtcat cctggccgtc tgcctgttgt gctatgtcag catcaccaag   1080

attaagaaag aatggtggga tcagattccc aacccagccc gcagccgcct cgtggctata   1140

ataatccagg atgctcaggg gtcacagtgg gagaagcggt cccgaggcca ggaaccagcc   1200

aagtgcccac actggaagaa ttgtcttacc aagctcttgc cctgttttct ggagcacaac   1260

atgaaaaggg atgaagatcc tcacaaggct gccaaagaga tgcctttcca gggctctgga   1320

aaatcagcat ggtgcccagt ggagatcagc aagacagtcc tctggccaga gagcatcagc   1380

gtggtgcgat gtgtggagtt gtttgaggcc ccggtggagt gtgaggagga ggaggaggta   1440

gaggaagaaa aagggagctt ctgtgcatcg cctgagagca gcagggatga cttccaggag   1500

ggaagggagg gcattgtggc ccggctaaca gagagcctgt tcctggacct gctcggagag   1560

gagaatgggg gcttttgcca gcaggacatg ggggagtcat gccttcttcc accttcggga   1620

agtacgagtg ctcacatgcc ctgggatgag ttcccaagtg cagggcccaa ggaggcacct   1680

ccctggggca aggagcagcc tctccacctg gagccaagtc ctcctgccag cccgacccag   1740

agtccagaca acctgacttg cacagagacg cccctcgtca tcgcaggcaa ccctgcttac   1800

cgcagcttca gcaactccct gagccagtca ccgtgtccca gagagctggg tccagaccca   1860

ctgctggcca gacacctgga ggaagtagaa cccgagatgc cctgtgtccc ccagctctct   1920

gagccaacca ctgtgcccca acctgagcca gaaacctggg agcagatcct ccgccgaaat   1980

gtcctccagc atggggcagc tgcagccccc gtctcggccc ccaccagtgg ctatcaggag   2040

tttgtacatg cggtggagca gggtggcacc caggccagtg cggtggtggg cttgggtccc   2100

ccaggagagg ctggttacaa ggccttctca agcctgcttg ccagcagtgc tgtgtcccca   2160

gagaaatgtg ggtttggggc tagcagtggg gaagaggggt ataagccttt ccaagacctc   2220

attcctggct gccctgggga ccctgcccca gtccctgtcc ccttgttcac ctttggactg   2280

gacagggagc cacctcgcag tccgcagagc tcacatctcc caagcagctc cccagagcac   2340

ctgggtctgg agccggggga aaaggtagag gacatgccaa agcccccact tccccaggag   2400

caggccacag acccccttgt ggacagcctg ggcagtggca ttgtctactc agcccttacc   2460

tgccacctgt gcggccacct gaaacagtgt catggccagg aggatggtgg ccagacccct   2520

gtcatggcca gtccttgctg tggctgctgc tgtggagaca ggtcctcgcc ccctacaacc   2580

cccctgaggg ccccagaccc ctctccaggt ggggttccac tggaggccag tctgtgtccg   2640

gcctccctgg caccctcggg catctcagag aagagtaaat cctcatcatc cttccatcct   2700

gcccctggca atgctcagag ctcaagccag acccccaaaa tcgtgaactt tgtctccgtg   2760

ggacccacat acatgagggt ctcttaggtg catgtcctct tgttgctgag tctgcagatg   2820

aggactaggg cttatccatg cctgggaaat gccacctcct ggaaggcagc caggctggca   2880

gatttccaaa agacttgaag aaccatggta tgaaggtgat tggccccact gacgttggcc   2940

taacactggg ctgcagagac tggaccccgc ccagcattgg gctgggctcg ccacatccca   3000

tgagagtaga gggcactggg tcgccgtgcc ccacggcagg cccctgcagg aaaactgagg   3060

cccttgggca cctcgacttg tgaacgagtt gttggctgct ccctccacag cttctgcagc   3120

agactgtccc tgttgtaact gcccaaggca tgttttgccc accagatcat ggcccacgtg   3180

gaggcccacc tgcctctgtc tcactgaact agaagccgag cctagaaact aacacagcca   3240

tcaagggaat gacttgggcg gccttgggaa atcgatgaga aattgaactt cagggagggt   3300

ggtcattgcc tagaggtgct cattcattta acagagcttc cttaggttga tgctggaggc   3360

agaatcccgg ctgtcaaggg gtgttcagtt aaggggagca acagaggaca tgaaaaattg   3420

ctatgactaa agcagggaca atttgctgcc aaacacccat gcccagctgt atggctgggg   3480

gctcctcgta tgcatggaac ccccagaata aatatgctca gccaccctgt gggccgggca   3540

atccagacag caggcataag gcaccagtta ccctgcatgt tggcccagac ctcaggtgct   3600

agggaaggcg ggaaccttgg gttgagtaat gctcgtctgt gtgttttagt ttcatcacct   3660

gttatctgtg tttgctgagg agagtggaac agaaggggtg gagttttgta taaataaagt   3720

ttctttgtct cttta                                                    3735


<210>  16
<211>  3486
<212>  DNA
<213>  Homo sapiens

<400>  16
acttcccgct tgggcgcccg gacggcgaat ggagcagggg cgcgcaggtg ccttggcatc     60

tcccaatggg gtggctttgc tctgggctcc tgttccctgt gagctgcctg gtcctgctgc    120

aggtggcaag ctctgggaac atgaaggtct tgcaggagcc cacctgcgtc tccgactaca    180

tgagcatctc tacttgcgag tggaagatga atggtcccac caattgcagc accgagctcc    240

gcctgttgta ccagctggtt tttctgctct ccgaagccca cacgtgtatc cctgagaaca    300

acggaggcgc ggggtgcgtg tgccacctgc tcatggatga cgtggtcagt gcggataact    360

atacactgga cctgtgggct gggcagcagc tgctgtggaa gggctccttc aagcccagcg    420

agcatgtgaa acccagggcc ccaggaaacc tgacagttca caccaatgtc tccgacactc    480

tgctgctgac ctggagcaac ccgtatcccc ctgacaatta cctgtataat catctcacct    540

atgcagtcaa catttggagt gaaaacgacc cggcagataa tctataacgt gacctaccta    600

gaaccctccc tccgcatcgc agccagcacc ctgaagtctg ggatttccta cagggcacgg    660

gtgagggcct gggctcagtg ctataacacc acctggagtg agtggagccc cagcaccaag    720

tggcacaact cctacaggga gcccttcgag cagcacctcc tgctgggcgt cagcgtttcc    780

tgcattgtca tcctggccgt ctgcctgttg tgctatgtca gcatcaccaa gattaagaaa    840

gaatggtggg atcagattcc caacccagcc cgcagccgcc tcgtggctat aataatccag    900

gatgctcagg ggtcacagtg ggagaagcgg tcccgaggcc aggaaccagc caagtgccca    960

cactggaaga attgtcttac caagctcttg ccctgttttc tggagcacaa catgaaaagg   1020

gatgaagatc ctcacaaggc tgccaaagag atgcctttcc agggctctgg aaaatcagca   1080

tggtgcccag tggagatcag caagacagtc ctctggccag agagcatcag cgtggtgcga   1140

tgtgtggagt tgtttgaggc cccggtggag tgtgaggagg aggaggaggt agaggaagaa   1200

aaagggagct tctgtgcatc gcctgagagc agcagggatg acttccagga gggaagggag   1260

ggcattgtgg cccggctaac agagagcctg ttcctggacc tgctcggaga ggagaatggg   1320

ggcttttgcc agcaggacat gggggagtca tgccttcttc caccttcggg aagtacgagt   1380

gctcacatgc cctgggatga gttcccaagt gcagggccca aggaggcacc tccctggggc   1440

aaggagcagc ctctccacct ggagccaagt cctcctgcca gcccgaccca gagtccagac   1500

aacctgactt gcacagagac gcccctcgtc atcgcaggca accctgctta ccgcagcttc   1560

agcaactccc tgagccagtc accgtgtccc agagagctgg gtccagaccc actgctggcc   1620

agacacctgg aggaagtaga acccgagatg ccctgtgtcc cccagctctc tgagccaacc   1680

actgtgcccc aacctgagcc agaaacctgg gagcagatcc tccgccgaaa tgtcctccag   1740

catggggcag ctgcagcccc cgtctcggcc cccaccagtg gctatcagga gtttgtacat   1800

gcggtggagc agggtggcac ccaggccagt gcggtggtgg gcttgggtcc cccaggagag   1860

gctggttaca aggccttctc aagcctgctt gccagcagtg ctgtgtcccc agagaaatgt   1920

gggtttgggg ctagcagtgg ggaagagggg tataagcctt tccaagacct cattcctggc   1980

tgccctgggg accctgcccc agtccctgtc cccttgttca cctttggact ggacagggag   2040

ccacctcgca gtccgcagag ctcacatctc ccaagcagct ccccagagca cctgggtctg   2100

gagccggggg aaaaggtaga ggacatgcca aagcccccac ttccccagga gcaggccaca   2160

gacccccttg tggacagcct gggcagtggc attgtctact cagcccttac ctgccacctg   2220

tgcggccacc tgaaacagtg tcatggccag gaggatggtg gccagacccc tgtcatggcc   2280

agtccttgct gtggctgctg ctgtggagac aggtcctcgc cccctacaac ccccctgagg   2340

gccccagacc cctctccagg tggggttcca ctggaggcca gtctgtgtcc ggcctccctg   2400

gcaccctcgg gcatctcaga gaagagtaaa tcctcatcat ccttccatcc tgcccctggc   2460

aatgctcaga gctcaagcca gacccccaaa atcgtgaact ttgtctccgt gggacccaca   2520

tacatgaggg tctcttaggt gcatgtcctc ttgttgctga gtctgcagat gaggactagg   2580

gcttatccat gcctgggaaa tgccacctcc tggaaggcag ccaggctggc agatttccaa   2640

aagacttgaa gaaccatggt atgaaggtga ttggccccac tgacgttggc ctaacactgg   2700

gctgcagaga ctggaccccg cccagcattg ggctgggctc gccacatccc atgagagtag   2760

agggcactgg gtcgccgtgc cccacggcag gcccctgcag gaaaactgag gcccttgggc   2820

acctcgactt gtgaacgagt tgttggctgc tccctccaca gcttctgcag cagactgtcc   2880

ctgttgtaac tgcccaaggc atgttttgcc caccagatca tggcccacgt ggaggcccac   2940

ctgcctctgt ctcactgaac tagaagccga gcctagaaac taacacagcc atcaagggaa   3000

tgacttgggc ggccttggga aatcgatgag aaattgaact tcagggaggg tggtcattgc   3060

ctagaggtgc tcattcattt aacagagctt ccttaggttg atgctggagg cagaatcccg   3120

gctgtcaagg ggtgttcagt taaggggagc aacagaggac atgaaaaatt gctatgacta   3180

aagcagggac aatttgctgc caaacaccca tgcccagctg tatggctggg ggctcctcgt   3240

atgcatggaa cccccagaat aaatatgctc agccaccctg tgggccgggc aatccagaca   3300

gcaggcataa ggcaccagtt accctgcatg ttggcccaga cctcaggtgc tagggaaggc   3360

gggaaccttg ggttgagtaa tgctcgtctg tgtgttttag tttcatcacc tgttatctgt   3420

gtttgctgag gagagtggaa cagaaggggt ggagttttgt ataaataaag tttctttgtc   3480

tcttta                                                              3486


<210>  17
<211>  1127
<212>  DNA
<213>  Homo sapiens

<400>  17
attctgccct cgagcccacc gggaacgaaa gagaagctct atctcccctc caggagccca     60

gctatgaact ccttctccac aagcgccttc ggtccagttg ccttctccct ggggctgctc    120

ctggtgttgc ctgctgcctt ccctgcccca gtacccccag gagaagattc caaagatgta    180

gccgccccac acagacagcc actcacctct tcagaacgaa ttgacaaaca aattcggtac    240

atcctcgacg gcatctcagc cctgagaaag gagacatgta acaagagtaa catgtgtgaa    300

agcagcaaag aggcactggc agaaaacaac ctgaaccttc caaagatggc tgaaaaagat    360

ggatgcttcc aatctggatt caatgaggag acttgcctgg tgaaaatcat cactggtctt    420

ttggagtttg aggtatacct agagtacctc cagaacagat ttgagagtag tgaggaacaa    480

gccagagctg tgcagatgag tacaaaagtc ctgatccagt tcctgcagaa aaaggcaaag    540

aatctagatg caataaccac ccctgaccca accacaaatg ccagcctgct gacgaagctg    600

caggcacaga accagtggct gcaggacatg acaactcatc tcattctgcg cagctttaag    660

gagttcctgc agtccagcct gagggctctt cggcaaatgt agcatgggca cctcagattg    720

ttgttgttaa tgggcattcc ttcttctggt cagaaacctg tccactgggc acagaactta    780

tgttgttctc tatggagaac taaaagtatg agcgttagga cactatttta attattttta    840

atttattaat atttaaatat gtgaagctga gttaatttat gtaagtcata tttatatttt    900

taagaagtac cacttgaaac attttatgta ttagttttga aataataatg gaaagtggct    960

atgcagtttg aatatccttt gtttcagagc cagatcattt cttggaaagt gtaggcttac   1020

ctcaaataaa tggctaactt atacatattt ttaaagaaat atttatattg tatttatata   1080

atgtataaat ggtttttata ccaataaatg gcattttaaa aaattca                 1127


<210>  18
<211>  936
<212>  DNA
<213>  Homo sapiens

<400>  18
attctgccct cgagcccacc gggaacgaaa gagaagctct atctcccctc caggagccca     60

gctatgaact ccttctccac aaacatgtaa caagagtaac atgtgtgaaa gcagcaaaga    120

ggcactggca gaaaacaacc tgaaccttcc aaagatggct gaaaaagatg gatgcttcca    180

atctggattc aatgaggaga cttgcctggt gaaaatcatc actggtcttt tggagtttga    240

ggtataccta gagtacctcc agaacagatt tgagagtagt gaggaacaag ccagagctgt    300

gcagatgagt acaaaagtcc tgatccagtt cctgcagaaa aaggcaaaga atctagatgc    360

aataaccacc cctgacccaa ccacaaatgc cagcctgctg acgaagctgc aggcacagaa    420

ccagtggctg caggacatga caactcatct cattctgcgc agctttaagg agttcctgca    480

gtccagcctg agggctcttc ggcaaatgta gcatgggcac ctcagattgt tgttgttaat    540

gggcattcct tcttctggtc agaaacctgt ccactgggca cagaacttat gttgttctct    600

atggagaact aaaagtatga gcgttaggac actattttaa ttatttttaa tttattaata    660

tttaaatatg tgaagctgag ttaatttatg taagtcatat ttatattttt aagaagtacc    720

acttgaaaca ttttatgtat tagttttgaa ataataatgg aaagtggcta tgcagtttga    780

atatcctttg tttcagagcc agatcatttc ttggaaagtg taggcttacc tcaaataaat    840

ggctaactta tacatatttt taaagaaata tttatattgt atttatataa tgtataaatg    900

gtttttatac caataaatgg cattttaaaa aattca                              936


<210>  19
<211>  1058
<212>  DNA
<213>  Homo sapiens

<400>  19
attctgccct cgagcccacc gggaacgaaa gagaagctct atctcccctc caggagccca     60

gctatgaact ccttctccac aataccccca ggagaagatt ccaaagatgt agccgcccca    120

cacagacagc cactcacctc ttcagaacga attgacaaac aaattcggta catcctcgac    180

ggcatctcag ccctgagaaa ggagacatgt aacaagagta acatgtgtga aagcagcaaa    240

gaggcactgg cagaaaacaa cctgaacctt ccaaagatgg ctgaaaaaga tggatgcttc    300

caatctggat tcaatgagga gacttgcctg gtgaaaatca tcactggtct tttggagttt    360

gaggtatacc tagagtacct ccagaacaga tttgagagta gtgaggaaca agccagagct    420

gtgcagatga gtacaaaagt cctgatccag ttcctgcaga aaaaggcaaa gaatctagat    480

gcaataacca cccctgaccc aaccacaaat gccagcctgc tgacgaagct gcaggcacag    540

aaccagtggc tgcaggacat gacaactcat ctcattctgc gcagctttaa ggagttcctg    600

cagtccagcc tgagggctct tcggcaaatg tagcatgggc acctcagatt gttgttgtta    660

atgggcattc cttcttctgg tcagaaacct gtccactggg cacagaactt atgttgttct    720

ctatggagaa ctaaaagtat gagcgttagg acactatttt aattattttt aatttattaa    780

tatttaaata tgtgaagctg agttaattta tgtaagtcat atttatattt ttaagaagta    840

ccacttgaaa cattttatgt attagttttg aaataataat ggaaagtggc tatgcagttt    900

gaatatcctt tgtttcagag ccagatcatt tcttggaaag tgtaggctta cctcaaataa    960

atggctaact tatacatatt tttaaagaaa tatttatatt gtatttatat aatgtataaa   1020

tggtttttat accaataaat ggcattttaa aaaattca                           1058


<210>  20
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  21
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr 
    210                 215                 220                 


Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu 
225                 230                 235                 240 


Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp 
                245                 250                 255     


Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe 
            260                 265                 270         


Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His 
        275                 280                 285             


Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val 
    290                 295                 300                 


Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala 
305                 310                 315                 320 


His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro 
                325                 330                 335     


His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu 
            340                 345                 350         


Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly 
        355                 360                 365             


Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala 
    370                 375                 380                 


Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro 
385                 390                 395                 400 


Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His 
                405                 410                 415     


Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
            420                 425                 430         


Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu 
        435                 440                 445             


Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln 
    450                 455                 460                 


Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp 
465                 470                 475                 480 


Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp 
                485                 490                 495     


Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr 
            500                 505                 510         


Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg 
        515                 520                 525             


Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr 
    530                 535                 540                 


Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser 
545                 550                 555                 560 


Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His 
                565                 570                 575     


Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala 
            580                 585                 590         


Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu 
        595                 600                 605             


Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys 
    610                 615                 620                 


Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val 
625                 630                 635                 640 


Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu 
                645                 650                 655     


Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys 
            660                 665                 670         


Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg 
        675                 680                 685             


Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 


<210>  22
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met 
    210                 215                 220                 


Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr 
225                 230                 235                 240 


Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr 
                245                 250                 255     


Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu 
            260                 265                 270         


Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg 
        275                 280                 285             


Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
    290                 295                 300                 


Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
305                 310                 315                 320 


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
                325                 330                 335     


Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
            340                 345                 350         


Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 
        355                 360                 365             


Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
    370                 375                 380                 


Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 
385                 390                 395                 400 


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
                405                 410                 415     


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
            420                 425                 430         


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
        435                 440                 445             


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
    450                 455                 460                 


Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 
465                 470                 475                 480 


Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
                485                 490             


<210>  23
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 
    210                 215                 220                 


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
                245                 250                 255     


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn 
    290                 295                 300                 


Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly 
305                 310                 315                 320 


Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser 
                325                 330                 335     


Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu 
            340                 345                 350         


Gln Asn Val Asp Met Lys Ile Gly Val 
        355                 360     


<210>  24
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Ser Leu His 
65                  70                  75                  80  


Cys Ser Gln Gln Ser Lys Lys Val Trp Ala Glu Glu Lys Ala Ser Asp 
                85                  90                  95      


Gln Gln Trp Gln Trp Ser Cys Gly Gly Gln Lys Ala Lys Trp Thr Gln 
            100                 105                 110         


Arg Arg Gly Gln Gln Val Ser Gly Asn Gly Ala Phe Gly Glu Gln Gly 
        115                 120                 125             


Val Val Arg Asn Ser Arg Pro Val Tyr Asp Ser 
    130                 135                 


<210>  25
<211>  5431
<212>  DNA
<213>  Homo sapiens

<400>  25
ctcattgccc agcggacccc agcctctgcc aggttcggtc cgccatcctc gtcccgtcct     60

ccgccggccc ctgccccgcg cccagggatc ctccagctcc tttcgcccgc gccctccgtt    120

cgctccggac accatggaca agttttggtg gcacgcagcc tggggactct gcctcgtgcc    180

gctgagcctg gcgcagatcg atttgaatat aacctgccgc tttgcaggtg tattccacgt    240

ggagaaaaat ggtcgctaca gcatctctcg gacggaggcc gctgacctct gcaaggcttt    300

caatagcacc ttgcccacaa tggcccagat ggagaaagct ctgagcatcg gatttgagac    360

ctgcaggtat gggttcatag aagggcacgt ggtgattccc cggatccacc ccaactccat    420

ctgtgcagca aacaacacag gggtgtacat cctcacatcc aacacctccc agtatgacac    480

atattgcttc aatgcttcag ctccacctga agaagattgt acatcagtca cagacctgcc    540

caatgccttt gatggaccaa ttaccataac tattgttaac cgtgatggca cccgctatgt    600

ccagaaagga gaatacagaa cgaatcctga agacatctac cccagcaacc ctactgatga    660

tgacgtgagc agcggctcct ccagtgaaag gagcagcact tcaggaggtt acatctttta    720

caccttttct actgtacacc ccatcccaga cgaagacagt ccctggatca ccgacagcac    780

agacagaatc cctgctacca ctttgatgag cactagtgct acagcaactg agacagcaac    840

caagaggcaa gaaacctggg attggttttc atggttgttt ctaccatcag agtcaaagaa    900

tcatcttcac acaacaacac aaatggctgg tacgtcttca aataccatct cagcaggctg    960

ggagccaaat gaagaaaatg aagatgaaag agacagacac ctcagttttt ctggatcagg   1020

cattgatgat gatgaagatt ttatctccag caccatttca accacaccac gggcttttga   1080

ccacacaaaa cagaaccagg actggaccca gtggaaccca agccattcaa atccggaagt   1140

gctacttcag acaaccacaa ggatgactga tgtagacaga aatggcacca ctgcttatga   1200

aggaaactgg aacccagaag cacaccctcc cctcattcac catgagcatc atgaggaaga   1260

agagacccca cattctacaa gcacaatcca ggcaactcct agtagtacaa cggaagaaac   1320

agctacccag aaggaacagt ggtttggcaa cagatggcat gagggatatc gccaaacacc   1380

caaagaagac tcccattcga caacagggac agctgcagcc tcagctcata ccagccatcc   1440

aatgcaagga aggacaacac caagcccaga ggacagttcc tggactgatt tcttcaaccc   1500

aatctcacac cccatgggac gaggtcatca agcaggaaga aggatggata tggactccag   1560

tcatagtata acgcttcagc ctactgcaaa tccaaacaca ggtttggtgg aagatttgga   1620

caggacagga cctctttcaa tgacaacgca gcagagtaat tctcagagct tctctacatc   1680

acatgaaggc ttggaagaag ataaagacca tccaacaact tctactctga catcaagcaa   1740

taggaatgat gtcacaggtg gaagaagaga cccaaatcat tctgaaggct caactacttt   1800

actggaaggt tatacctctc attacccaca cacgaaggaa agcaggacct tcatcccagt   1860

gacctcagct aagactgggt cctttggagt tactgcagtt actgttggag attccaactc   1920

taatgtcaat cgttccttat caggagacca agacacattc caccccagtg gggggtccca   1980

taccactcat ggatctgaat cagatggaca ctcacatggg agtcaagaag gtggagcaaa   2040

cacaacctct ggtcctataa ggacacccca aattccagaa tggctgatca tcttggcatc   2100

cctcttggcc ttggctttga ttcttgcagt ttgcattgca gtcaacagtc gaagaaggtg   2160

tgggcagaag aaaaagctag tgatcaacag tggcaatgga gctgtggagg acagaaagcc   2220

aagtggactc aacggagagg ccagcaagtc tcaggaaatg gtgcatttgg tgaacaagga   2280

gtcgtcagaa actccagacc agtttatgac agctgatgag acaaggaacc tgcagaatgt   2340

ggacatgaag attggggtgt aacacctaca ccattatctt ggaaagaaac aaccgttgga   2400

aacataacca ttacagggag ctgggacact taacagatgc aatgtgctac tgattgtttc   2460

attgcgaatc ttttttagca taaaattttc tactcttttt gttttttgtg ttttgttctt   2520

taaagtcagg tccaatttgt aaaaacagca ttgctttctg aaattagggc ccaattaata   2580

atcagcaaga atttgatcgt tccagttccc acttggaggc ctttcatccc tcgggtgtgc   2640

tatggatggc ttctaacaaa aactacacat atgtattcct gatcgccaac ctttccccca   2700

ccagctaagg acatttccca gggttaatag ggcctggtcc ctgggaggaa atttgaatgg   2760

gtccattttg cccttccata gcctaatccc tgggcattgc tttccactga ggttgggggt   2820

tggggtgtac tagttacaca tcttcaacag accccctcta gaaatttttc agatgcttct   2880

gggagacacc caaagggtga agctatttat ctgtagtaaa ctatttatct gtgtttttga   2940

aatattaaac cctggatcag tcctttgatc agtataattt tttaaagtta ctttgtcaga   3000

ggcacaaaag ggtttaaact gattcataat aaatatctgt acttcttcga tcttcacctt   3060

ttgtgctgtg attcttcagt ttctaaacca gcactgtctg ggtccctaca atgtatcagg   3120

aagagctgag aatggtaagg agactcttct aagtcttcat ctcagagacc ctgagttccc   3180

actcagaccc actcagccaa atctcatgga agaccaagga gggcagcact gtttttgttt   3240

tttgtttttt gttttttttt tttgacactg tccaaaggtt ttccatcctg tcctggaatc   3300

agagttggaa gctgaggagc ttcagcctct tttatggttt aatggccacc tgttctctcc   3360

tgtgaaaggc tttgcaaagt cacattaagt ttgcatgacc tgttatccct ggggccctat   3420

ttcatagagg ctggccctat tagtgatttc caaaaacaat atggaagtgc cttttgatgt   3480

cttacaataa gagaagaagc caatggaaat gaaagagatt ggcaaagggg aaggatgatg   3540

ccatgtagat cctgtttgac atttttatgg ctgtatttgt aaacttaaac acaccagtgt   3600

ctgttcttga tgcagttgct atttaggatg agttaagtgc ctggggagtc cctcaaaagg   3660

ttaaagggat tcccatcatt ggaatcttat caccagatag gcaagtttat gaccaaacaa   3720

gagagtactg gctttatcct ctaacctcat attttctccc acttggcaag tcctttgtgg   3780

catttattca tcagtcaggg tgtccgattg gtcctagaac ttccaaaggc tgcttgtcat   3840

agaagccatt gcatctataa agcaacggct cctgttaaat ggtatctcct ttctgaggct   3900

cctactaaaa gtcatttgtt acctaaactt atgtgcttaa caggcaatgc ttctcagacc   3960

acaaagcaga aagaagaaga aaagctcctg actaaatcag ggctgggctt agacagagtt   4020

gatctgtaga atatctttaa aggagagatg tcaactttct gcactattcc cagcctctgc   4080

tcctccctgt ctaccctctc ccctccctct ctccctccac ttcaccccac aatcttgaaa   4140

aacttccttt ctcttctgtg aacatcattg gccagatcca ttttcagtgg tctggatttc   4200

tttttatttt cttttcaact tgaaagaaac tggacattag gccactatgt gttgttactg   4260

ccactagtgt tcaagtgcct cttgttttcc cagagatttc ctgggtctgc cagaggccca   4320

gacaggctca ctcaagctct ttaactgaaa agcaacaagc cactccagga caaggttcaa   4380

aatggttaca acagcctcta cctgtcgccc cagggagaaa ggggtagtga tacaagtctc   4440

atagccagag atggttttcc actccttcta gatattccca aaaagaggct gagacaggag   4500

gttattttca attttatttt ggaattaaat acttttttcc ctttattact gttgtagtcc   4560

ctcacttgga tatacctctg ttttcacgat agaaataagg gaggtctaga gcttctattc   4620

cttggccatt gtcaacggag agctggccaa gtcttcacaa acccttgcaa cattgcctga   4680

agtttatgga ataagatgta ttctcactcc cttgatctca agggcgtaac tctggaagca   4740

cagcttgact acacgtcatt tttaccaatg attttcaggt gacctgggct aagtcattta   4800

aactgggtct ttataaaagt aaaaggccaa catttaatta ttttgcaaag caacctaaga   4860

gctaaagatg taatttttct tgcaattgta aatcttttgt gtctcctgaa gacttccctt   4920

aaaattagct ctgagtgaaa aatcaaaaga gacaaaagac atcttcgaat ccatatttca   4980

agcctggtag aattggcttt tctagcagaa cctttccaaa agttttatat tgagattcat   5040

aacaacacca agaattgatt ttgtagccaa cattcattca atactgttat atcagaggag   5100

taggagagag gaaacatttg acttatctgg aaaagcaaaa tgtacttaag aataagaata   5160

acatggtcca ttcaccttta tgttatagat atgtctttgt gtaaatcatt tgttttgagt   5220

tttcaaagaa tagcccattg ttcattcttg tgctgtacaa tgaccactgt tattgttact   5280

ttgacttttc agagcacacc cttcctctgg tttttgtata tttattgatg gatcaataat   5340

aatgaggaaa gcatgatatg tatattgctg agttgaaagc acttattgga aaatattaaa   5400

aggctaacat taaaagacta aaggaaacag a                                  5431


<210>  26
<211>  5302
<212>  DNA
<213>  Homo sapiens

<400>  26
ctcattgccc agcggacccc agcctctgcc aggttcggtc cgccatcctc gtcccgtcct     60

ccgccggccc ctgccccgcg cccagggatc ctccagctcc tttcgcccgc gccctccgtt    120

cgctccggac accatggaca agttttggtg gcacgcagcc tggggactct gcctcgtgcc    180

gctgagcctg gcgcagatcg atttgaatat aacctgccgc tttgcaggtg tattccacgt    240

ggagaaaaat ggtcgctaca gcatctctcg gacggaggcc gctgacctct gcaaggcttt    300

caatagcacc ttgcccacaa tggcccagat ggagaaagct ctgagcatcg gatttgagac    360

ctgcaggtat gggttcatag aagggcacgt ggtgattccc cggatccacc ccaactccat    420

ctgtgcagca aacaacacag gggtgtacat cctcacatcc aacacctccc agtatgacac    480

atattgcttc aatgcttcag ctccacctga agaagattgt acatcagtca cagacctgcc    540

caatgccttt gatggaccaa ttaccataac tattgttaac cgtgatggca cccgctatgt    600

ccagaaagga gaatacagaa cgaatcctga agacatctac cccagcaacc ctactgatga    660

tgacgtgagc agcggctcct ccagtgaaag gagcagcact tcaggaggtt acatctttta    720

caccttttct actgtacacc ccatcccaga cgaagacagt ccctggatca ccgacagcac    780

agacagaatc cctgctacca gtacgtcttc aaataccatc tcagcaggct gggagccaaa    840

tgaagaaaat gaagatgaaa gagacagaca cctcagtttt tctggatcag gcattgatga    900

tgatgaagat tttatctcca gcaccatttc aaccacacca cgggcttttg accacacaaa    960

acagaaccag gactggaccc agtggaaccc aagccattca aatccggaag tgctacttca   1020

gacaaccaca aggatgactg atgtagacag aaatggcacc actgcttatg aaggaaactg   1080

gaacccagaa gcacaccctc ccctcattca ccatgagcat catgaggaag aagagacccc   1140

acattctaca agcacaatcc aggcaactcc tagtagtaca acggaagaaa cagctaccca   1200

gaaggaacag tggtttggca acagatggca tgagggatat cgccaaacac ccaaagaaga   1260

ctcccattcg acaacaggga cagctgcagc ctcagctcat accagccatc caatgcaagg   1320

aaggacaaca ccaagcccag aggacagttc ctggactgat ttcttcaacc caatctcaca   1380

ccccatggga cgaggtcatc aagcaggaag aaggatggat atggactcca gtcatagtat   1440

aacgcttcag cctactgcaa atccaaacac aggtttggtg gaagatttgg acaggacagg   1500

acctctttca atgacaacgc agcagagtaa ttctcagagc ttctctacat cacatgaagg   1560

cttggaagaa gataaagacc atccaacaac ttctactctg acatcaagca ataggaatga   1620

tgtcacaggt ggaagaagag acccaaatca ttctgaaggc tcaactactt tactggaagg   1680

ttatacctct cattacccac acacgaagga aagcaggacc ttcatcccag tgacctcagc   1740

taagactggg tcctttggag ttactgcagt tactgttgga gattccaact ctaatgtcaa   1800

tcgttcctta tcaggagacc aagacacatt ccaccccagt ggggggtccc ataccactca   1860

tggatctgaa tcagatggac actcacatgg gagtcaagaa ggtggagcaa acacaacctc   1920

tggtcctata aggacacccc aaattccaga atggctgatc atcttggcat ccctcttggc   1980

cttggctttg attcttgcag tttgcattgc agtcaacagt cgaagaaggt gtgggcagaa   2040

gaaaaagcta gtgatcaaca gtggcaatgg agctgtggag gacagaaagc caagtggact   2100

caacggagag gccagcaagt ctcaggaaat ggtgcatttg gtgaacaagg agtcgtcaga   2160

aactccagac cagtttatga cagctgatga gacaaggaac ctgcagaatg tggacatgaa   2220

gattggggtg taacacctac accattatct tggaaagaaa caaccgttgg aaacataacc   2280

attacaggga gctgggacac ttaacagatg caatgtgcta ctgattgttt cattgcgaat   2340

cttttttagc ataaaatttt ctactctttt tgttttttgt gttttgttct ttaaagtcag   2400

gtccaatttg taaaaacagc attgctttct gaaattaggg cccaattaat aatcagcaag   2460

aatttgatcg ttccagttcc cacttggagg cctttcatcc ctcgggtgtg ctatggatgg   2520

cttctaacaa aaactacaca tatgtattcc tgatcgccaa cctttccccc accagctaag   2580

gacatttccc agggttaata gggcctggtc cctgggagga aatttgaatg ggtccatttt   2640

gcccttccat agcctaatcc ctgggcattg ctttccactg aggttggggg ttggggtgta   2700

ctagttacac atcttcaaca gaccccctct agaaattttt cagatgcttc tgggagacac   2760

ccaaagggtg aagctattta tctgtagtaa actatttatc tgtgtttttg aaatattaaa   2820

ccctggatca gtcctttgat cagtataatt ttttaaagtt actttgtcag aggcacaaaa   2880

gggtttaaac tgattcataa taaatatctg tacttcttcg atcttcacct tttgtgctgt   2940

gattcttcag tttctaaacc agcactgtct gggtccctac aatgtatcag gaagagctga   3000

gaatggtaag gagactcttc taagtcttca tctcagagac cctgagttcc cactcagacc   3060

cactcagcca aatctcatgg aagaccaagg agggcagcac tgtttttgtt ttttgttttt   3120

tgtttttttt ttttgacact gtccaaaggt tttccatcct gtcctggaat cagagttgga   3180

agctgaggag cttcagcctc ttttatggtt taatggccac ctgttctctc ctgtgaaagg   3240

ctttgcaaag tcacattaag tttgcatgac ctgttatccc tggggcccta tttcatagag   3300

gctggcccta ttagtgattt ccaaaaacaa tatggaagtg ccttttgatg tcttacaata   3360

agagaagaag ccaatggaaa tgaaagagat tggcaaaggg gaaggatgat gccatgtaga   3420

tcctgtttga catttttatg gctgtatttg taaacttaaa cacaccagtg tctgttcttg   3480

atgcagttgc tatttaggat gagttaagtg cctggggagt ccctcaaaag gttaaaggga   3540

ttcccatcat tggaatctta tcaccagata ggcaagttta tgaccaaaca agagagtact   3600

ggctttatcc tctaacctca tattttctcc cacttggcaa gtcctttgtg gcatttattc   3660

atcagtcagg gtgtccgatt ggtcctagaa cttccaaagg ctgcttgtca tagaagccat   3720

tgcatctata aagcaacggc tcctgttaaa tggtatctcc tttctgaggc tcctactaaa   3780

agtcatttgt tacctaaact tatgtgctta acaggcaatg cttctcagac cacaaagcag   3840

aaagaagaag aaaagctcct gactaaatca gggctgggct tagacagagt tgatctgtag   3900

aatatcttta aaggagagat gtcaactttc tgcactattc ccagcctctg ctcctccctg   3960

tctaccctct cccctccctc tctccctcca cttcacccca caatcttgaa aaacttcctt   4020

tctcttctgt gaacatcatt ggccagatcc attttcagtg gtctggattt ctttttattt   4080

tcttttcaac ttgaaagaaa ctggacatta ggccactatg tgttgttact gccactagtg   4140

ttcaagtgcc tcttgttttc ccagagattt cctgggtctg ccagaggccc agacaggctc   4200

actcaagctc tttaactgaa aagcaacaag ccactccagg acaaggttca aaatggttac   4260

aacagcctct acctgtcgcc ccagggagaa aggggtagtg atacaagtct catagccaga   4320

gatggttttc cactccttct agatattccc aaaaagaggc tgagacagga ggttattttc   4380

aattttattt tggaattaaa tacttttttc cctttattac tgttgtagtc cctcacttgg   4440

atatacctct gttttcacga tagaaataag ggaggtctag agcttctatt ccttggccat   4500

tgtcaacgga gagctggcca agtcttcaca aacccttgca acattgcctg aagtttatgg   4560

aataagatgt attctcactc ccttgatctc aagggcgtaa ctctggaagc acagcttgac   4620

tacacgtcat ttttaccaat gattttcagg tgacctgggc taagtcattt aaactgggtc   4680

tttataaaag taaaaggcca acatttaatt attttgcaaa gcaacctaag agctaaagat   4740

gtaatttttc ttgcaattgt aaatcttttg tgtctcctga agacttccct taaaattagc   4800

tctgagtgaa aaatcaaaag agacaaaaga catcttcgaa tccatatttc aagcctggta   4860

gaattggctt ttctagcaga acctttccaa aagttttata ttgagattca taacaacacc   4920

aagaattgat tttgtagcca acattcattc aatactgtta tatcagagga gtaggagaga   4980

ggaaacattt gacttatctg gaaaagcaaa atgtacttaa gaataagaat aacatggtcc   5040

attcaccttt atgttataga tatgtctttg tgtaaatcat ttgttttgag ttttcaaaga   5100

atagcccatt gttcattctt gtgctgtaca atgaccactg ttattgttac tttgactttt   5160

cagagcacac ccttcctctg gtttttgtat atttattgat ggatcaataa taatgaggaa   5220

agcatgatat gtatattgct gagttgaaag cacttattgg aaaatattaa aaggctaaca   5280

ttaaaagact aaaggaaaca ga                                            5302


<210>  27
<211>  4684
<212>  DNA
<213>  Homo sapiens

<400>  27
ctcattgccc agcggacccc agcctctgcc aggttcggtc cgccatcctc gtcccgtcct     60

ccgccggccc ctgccccgcg cccagggatc ctccagctcc tttcgcccgc gccctccgtt    120

cgctccggac accatggaca agttttggtg gcacgcagcc tggggactct gcctcgtgcc    180

gctgagcctg gcgcagatcg atttgaatat aacctgccgc tttgcaggtg tattccacgt    240

ggagaaaaat ggtcgctaca gcatctctcg gacggaggcc gctgacctct gcaaggcttt    300

caatagcacc ttgcccacaa tggcccagat ggagaaagct ctgagcatcg gatttgagac    360

ctgcaggtat gggttcatag aagggcacgt ggtgattccc cggatccacc ccaactccat    420

ctgtgcagca aacaacacag gggtgtacat cctcacatcc aacacctccc agtatgacac    480

atattgcttc aatgcttcag ctccacctga agaagattgt acatcagtca cagacctgcc    540

caatgccttt gatggaccaa ttaccataac tattgttaac cgtgatggca cccgctatgt    600

ccagaaagga gaatacagaa cgaatcctga agacatctac cccagcaacc ctactgatga    660

tgacgtgagc agcggctcct ccagtgaaag gagcagcact tcaggaggtt acatctttta    720

caccttttct actgtacacc ccatcccaga cgaagacagt ccctggatca ccgacagcac    780

agacagaatc cctgctacca atatggactc cagtcatagt ataacgcttc agcctactgc    840

aaatccaaac acaggtttgg tggaagattt ggacaggaca ggacctcttt caatgacaac    900

gcagcagagt aattctcaga gcttctctac atcacatgaa ggcttggaag aagataaaga    960

ccatccaaca acttctactc tgacatcaag caataggaat gatgtcacag gtggaagaag   1020

agacccaaat cattctgaag gctcaactac tttactggaa ggttatacct ctcattaccc   1080

acacacgaag gaaagcagga ccttcatccc agtgacctca gctaagactg ggtcctttgg   1140

agttactgca gttactgttg gagattccaa ctctaatgtc aatcgttcct tatcaggaga   1200

ccaagacaca ttccacccca gtggggggtc ccataccact catggatctg aatcagatgg   1260

acactcacat gggagtcaag aaggtggagc aaacacaacc tctggtccta taaggacacc   1320

ccaaattcca gaatggctga tcatcttggc atccctcttg gccttggctt tgattcttgc   1380

agtttgcatt gcagtcaaca gtcgaagaag gtgtgggcag aagaaaaagc tagtgatcaa   1440

cagtggcaat ggagctgtgg aggacagaaa gccaagtgga ctcaacggag aggccagcaa   1500

gtctcaggaa atggtgcatt tggtgaacaa ggagtcgtca gaaactccag accagtttat   1560

gacagctgat gagacaagga acctgcagaa tgtggacatg aagattgggg tgtaacacct   1620

acaccattat cttggaaaga aacaaccgtt ggaaacataa ccattacagg gagctgggac   1680

acttaacaga tgcaatgtgc tactgattgt ttcattgcga atctttttta gcataaaatt   1740

ttctactctt tttgtttttt gtgttttgtt ctttaaagtc aggtccaatt tgtaaaaaca   1800

gcattgcttt ctgaaattag ggcccaatta ataatcagca agaatttgat cgttccagtt   1860

cccacttgga ggcctttcat ccctcgggtg tgctatggat ggcttctaac aaaaactaca   1920

catatgtatt cctgatcgcc aacctttccc ccaccagcta aggacatttc ccagggttaa   1980

tagggcctgg tccctgggag gaaatttgaa tgggtccatt ttgcccttcc atagcctaat   2040

ccctgggcat tgctttccac tgaggttggg ggttggggtg tactagttac acatcttcaa   2100

cagaccccct ctagaaattt ttcagatgct tctgggagac acccaaaggg tgaagctatt   2160

tatctgtagt aaactattta tctgtgtttt tgaaatatta aaccctggat cagtcctttg   2220

atcagtataa ttttttaaag ttactttgtc agaggcacaa aagggtttaa actgattcat   2280

aataaatatc tgtacttctt cgatcttcac cttttgtgct gtgattcttc agtttctaaa   2340

ccagcactgt ctgggtccct acaatgtatc aggaagagct gagaatggta aggagactct   2400

tctaagtctt catctcagag accctgagtt cccactcaga cccactcagc caaatctcat   2460

ggaagaccaa ggagggcagc actgtttttg ttttttgttt tttgtttttt ttttttgaca   2520

ctgtccaaag gttttccatc ctgtcctgga atcagagttg gaagctgagg agcttcagcc   2580

tcttttatgg tttaatggcc acctgttctc tcctgtgaaa ggctttgcaa agtcacatta   2640

agtttgcatg acctgttatc cctggggccc tatttcatag aggctggccc tattagtgat   2700

ttccaaaaac aatatggaag tgccttttga tgtcttacaa taagagaaga agccaatgga   2760

aatgaaagag attggcaaag gggaaggatg atgccatgta gatcctgttt gacattttta   2820

tggctgtatt tgtaaactta aacacaccag tgtctgttct tgatgcagtt gctatttagg   2880

atgagttaag tgcctgggga gtccctcaaa aggttaaagg gattcccatc attggaatct   2940

tatcaccaga taggcaagtt tatgaccaaa caagagagta ctggctttat cctctaacct   3000

catattttct cccacttggc aagtcctttg tggcatttat tcatcagtca gggtgtccga   3060

ttggtcctag aacttccaaa ggctgcttgt catagaagcc attgcatcta taaagcaacg   3120

gctcctgtta aatggtatct cctttctgag gctcctacta aaagtcattt gttacctaaa   3180

cttatgtgct taacaggcaa tgcttctcag accacaaagc agaaagaaga agaaaagctc   3240

ctgactaaat cagggctggg cttagacaga gttgatctgt agaatatctt taaaggagag   3300

atgtcaactt tctgcactat tcccagcctc tgctcctccc tgtctaccct ctcccctccc   3360

tctctccctc cacttcaccc cacaatcttg aaaaacttcc tttctcttct gtgaacatca   3420

ttggccagat ccattttcag tggtctggat ttctttttat tttcttttca acttgaaaga   3480

aactggacat taggccacta tgtgttgtta ctgccactag tgttcaagtg cctcttgttt   3540

tcccagagat ttcctgggtc tgccagaggc ccagacaggc tcactcaagc tctttaactg   3600

aaaagcaaca agccactcca ggacaaggtt caaaatggtt acaacagcct ctacctgtcg   3660

ccccagggag aaaggggtag tgatacaagt ctcatagcca gagatggttt tccactcctt   3720

ctagatattc ccaaaaagag gctgagacag gaggttattt tcaattttat tttggaatta   3780

aatacttttt tccctttatt actgttgtag tccctcactt ggatatacct ctgttttcac   3840

gatagaaata agggaggtct agagcttcta ttccttggcc attgtcaacg gagagctggc   3900

caagtcttca caaacccttg caacattgcc tgaagtttat ggaataagat gtattctcac   3960

tcccttgatc tcaagggcgt aactctggaa gcacagcttg actacacgtc atttttacca   4020

atgattttca ggtgacctgg gctaagtcat ttaaactggg tctttataaa agtaaaaggc   4080

caacatttaa ttattttgca aagcaaccta agagctaaag atgtaatttt tcttgcaatt   4140

gtaaatcttt tgtgtctcct gaagacttcc cttaaaatta gctctgagtg aaaaatcaaa   4200

agagacaaaa gacatcttcg aatccatatt tcaagcctgg tagaattggc ttttctagca   4260

gaacctttcc aaaagtttta tattgagatt cataacaaca ccaagaattg attttgtagc   4320

caacattcat tcaatactgt tatatcagag gagtaggaga gaggaaacat ttgacttatc   4380

tggaaaagca aaatgtactt aagaataaga ataacatggt ccattcacct ttatgttata   4440

gatatgtctt tgtgtaaatc atttgttttg agttttcaaa gaatagccca ttgttcattc   4500

ttgtgctgta caatgaccac tgttattgtt actttgactt ttcagagcac acccttcctc   4560

tggtttttgt atatttattg atggatcaat aataatgagg aaagcatgat atgtatattg   4620

ctgagttgaa agcacttatt ggaaaatatt aaaaggctaa cattaaaaga ctaaaggaaa   4680

caga                                                                4684


<210>  28
<211>  4288
<212>  DNA
<213>  Homo sapiens

<400>  28
ctcattgccc agcggacccc agcctctgcc aggttcggtc cgccatcctc gtcccgtcct     60

ccgccggccc ctgccccgcg cccagggatc ctccagctcc tttcgcccgc gccctccgtt    120

cgctccggac accatggaca agttttggtg gcacgcagcc tggggactct gcctcgtgcc    180

gctgagcctg gcgcagatcg atttgaatat aacctgccgc tttgcaggtg tattccacgt    240

ggagaaaaat ggtcgctaca gcatctctcg gacggaggcc gctgacctct gcaaggcttt    300

caatagcacc ttgcccacaa tggcccagat ggagaaagct ctgagcatcg gatttgagac    360

ctgcaggtat gggttcatag aagggcacgt ggtgattccc cggatccacc ccaactccat    420

ctgtgcagca aacaacacag gggtgtacat cctcacatcc aacacctccc agtatgacac    480

atattgcttc aatgcttcag ctccacctga agaagattgt acatcagtca cagacctgcc    540

caatgccttt gatggaccaa ttaccataac tattgttaac cgtgatggca cccgctatgt    600

ccagaaagga gaatacagaa cgaatcctga agacatctac cccagcaacc ctactgatga    660

tgacgtgagc agcggctcct ccagtgaaag gagcagcact tcaggaggtt acatctttta    720

caccttttct actgtacacc ccatcccaga cgaagacagt ccctggatca ccgacagcac    780

agacagaatc cctgctacca gagaccaaga cacattccac cccagtgggg ggtcccatac    840

cactcatgga tctgaatcag atggacactc acatgggagt caagaaggtg gagcaaacac    900

aacctctggt cctataagga caccccaaat tccagaatgg ctgatcatct tggcatccct    960

cttggccttg gctttgattc ttgcagtttg cattgcagtc aacagtcgaa gaaggtgtgg   1020

gcagaagaaa aagctagtga tcaacagtgg caatggagct gtggaggaca gaaagccaag   1080

tggactcaac ggagaggcca gcaagtctca ggaaatggtg catttggtga acaaggagtc   1140

gtcagaaact ccagaccagt ttatgacagc tgatgagaca aggaacctgc agaatgtgga   1200

catgaagatt ggggtgtaac acctacacca ttatcttgga aagaaacaac cgttggaaac   1260

ataaccatta cagggagctg ggacacttaa cagatgcaat gtgctactga ttgtttcatt   1320

gcgaatcttt tttagcataa aattttctac tctttttgtt ttttgtgttt tgttctttaa   1380

agtcaggtcc aatttgtaaa aacagcattg ctttctgaaa ttagggccca attaataatc   1440

agcaagaatt tgatcgttcc agttcccact tggaggcctt tcatccctcg ggtgtgctat   1500

ggatggcttc taacaaaaac tacacatatg tattcctgat cgccaacctt tcccccacca   1560

gctaaggaca tttcccaggg ttaatagggc ctggtccctg ggaggaaatt tgaatgggtc   1620

cattttgccc ttccatagcc taatccctgg gcattgcttt ccactgaggt tgggggttgg   1680

ggtgtactag ttacacatct tcaacagacc ccctctagaa atttttcaga tgcttctggg   1740

agacacccaa agggtgaagc tatttatctg tagtaaacta tttatctgtg tttttgaaat   1800

attaaaccct ggatcagtcc tttgatcagt ataatttttt aaagttactt tgtcagaggc   1860

acaaaagggt ttaaactgat tcataataaa tatctgtact tcttcgatct tcaccttttg   1920

tgctgtgatt cttcagtttc taaaccagca ctgtctgggt ccctacaatg tatcaggaag   1980

agctgagaat ggtaaggaga ctcttctaag tcttcatctc agagaccctg agttcccact   2040

cagacccact cagccaaatc tcatggaaga ccaaggaggg cagcactgtt tttgtttttt   2100

gttttttgtt tttttttttt gacactgtcc aaaggttttc catcctgtcc tggaatcaga   2160

gttggaagct gaggagcttc agcctctttt atggtttaat ggccacctgt tctctcctgt   2220

gaaaggcttt gcaaagtcac attaagtttg catgacctgt tatccctggg gccctatttc   2280

atagaggctg gccctattag tgatttccaa aaacaatatg gaagtgcctt ttgatgtctt   2340

acaataagag aagaagccaa tggaaatgaa agagattggc aaaggggaag gatgatgcca   2400

tgtagatcct gtttgacatt tttatggctg tatttgtaaa cttaaacaca ccagtgtctg   2460

ttcttgatgc agttgctatt taggatgagt taagtgcctg gggagtccct caaaaggtta   2520

aagggattcc catcattgga atcttatcac cagataggca agtttatgac caaacaagag   2580

agtactggct ttatcctcta acctcatatt ttctcccact tggcaagtcc tttgtggcat   2640

ttattcatca gtcagggtgt ccgattggtc ctagaacttc caaaggctgc ttgtcataga   2700

agccattgca tctataaagc aacggctcct gttaaatggt atctcctttc tgaggctcct   2760

actaaaagtc atttgttacc taaacttatg tgcttaacag gcaatgcttc tcagaccaca   2820

aagcagaaag aagaagaaaa gctcctgact aaatcagggc tgggcttaga cagagttgat   2880

ctgtagaata tctttaaagg agagatgtca actttctgca ctattcccag cctctgctcc   2940

tccctgtcta ccctctcccc tccctctctc cctccacttc accccacaat cttgaaaaac   3000

ttcctttctc ttctgtgaac atcattggcc agatccattt tcagtggtct ggatttcttt   3060

ttattttctt ttcaacttga aagaaactgg acattaggcc actatgtgtt gttactgcca   3120

ctagtgttca agtgcctctt gttttcccag agatttcctg ggtctgccag aggcccagac   3180

aggctcactc aagctcttta actgaaaagc aacaagccac tccaggacaa ggttcaaaat   3240

ggttacaaca gcctctacct gtcgccccag ggagaaaggg gtagtgatac aagtctcata   3300

gccagagatg gttttccact ccttctagat attcccaaaa agaggctgag acaggaggtt   3360

attttcaatt ttattttgga attaaatact tttttccctt tattactgtt gtagtccctc   3420

acttggatat acctctgttt tcacgataga aataagggag gtctagagct tctattcctt   3480

ggccattgtc aacggagagc tggccaagtc ttcacaaacc cttgcaacat tgcctgaagt   3540

ttatggaata agatgtattc tcactccctt gatctcaagg gcgtaactct ggaagcacag   3600

cttgactaca cgtcattttt accaatgatt ttcaggtgac ctgggctaag tcatttaaac   3660

tgggtcttta taaaagtaaa aggccaacat ttaattattt tgcaaagcaa cctaagagct   3720

aaagatgtaa tttttcttgc aattgtaaat cttttgtgtc tcctgaagac ttcccttaaa   3780

attagctctg agtgaaaaat caaaagagac aaaagacatc ttcgaatcca tatttcaagc   3840

ctggtagaat tggcttttct agcagaacct ttccaaaagt tttatattga gattcataac   3900

aacaccaaga attgattttg tagccaacat tcattcaata ctgttatatc agaggagtag   3960

gagagaggaa acatttgact tatctggaaa agcaaaatgt acttaagaat aagaataaca   4020

tggtccattc acctttatgt tatagatatg tctttgtgta aatcatttgt tttgagtttt   4080

caaagaatag cccattgttc attcttgtgc tgtacaatga ccactgttat tgttactttg   4140

acttttcaga gcacaccctt cctctggttt ttgtatattt attgatggat caataataat   4200

gaggaaagca tgatatgtat attgctgagt tgaaagcact tattggaaaa tattaaaagg   4260

ctaacattaa aagactaaag gaaacaga                                      4288


<210>  29
<211>  3668
<212>  DNA
<213>  Homo sapiens

<400>  29
ctcattgccc agcggacccc agcctctgcc aggttcggtc cgccatcctc gtcccgtcct     60

ccgccggccc ctgccccgcg cccagggatc ctccagctcc tttcgcccgc gccctccgtt    120

cgctccggac accatggaca agttttggtg gcacgcagcc tggggactct gcctcgtgcc    180

gctgagcctg gcgcagatcg atttgaatat aacctgccgc tttgcaggtg tattccacgt    240

ggagaaaaat ggtcgctaca gcatctctcg gacggaggcc gctgacctct gcaaggcttt    300

caatagcacc ttgcccacaa tggcccagat ggagaaagct ctgagcatcg gatttgagac    360

ctgcagtttg cattgcagtc aacagtcgaa gaaggtgtgg gcagaagaaa aagctagtga    420

tcaacagtgg caatggagct gtggaggaca gaaagccaag tggactcaac ggagaggcca    480

gcaagtctca ggaaatggtg catttggtga acaaggagtc gtcagaaact ccagaccagt    540

ttatgacagc tgatgagaca aggaacctgc agaatgtgga catgaagatt ggggtgtaac    600

acctacacca ttatcttgga aagaaacaac cgttggaaac ataaccatta cagggagctg    660

ggacacttaa cagatgcaat gtgctactga ttgtttcatt gcgaatcttt tttagcataa    720

aattttctac tctttttgtt ttttgtgttt tgttctttaa agtcaggtcc aatttgtaaa    780

aacagcattg ctttctgaaa ttagggccca attaataatc agcaagaatt tgatcgttcc    840

agttcccact tggaggcctt tcatccctcg ggtgtgctat ggatggcttc taacaaaaac    900

tacacatatg tattcctgat cgccaacctt tcccccacca gctaaggaca tttcccaggg    960

ttaatagggc ctggtccctg ggaggaaatt tgaatgggtc cattttgccc ttccatagcc   1020

taatccctgg gcattgcttt ccactgaggt tgggggttgg ggtgtactag ttacacatct   1080

tcaacagacc ccctctagaa atttttcaga tgcttctggg agacacccaa agggtgaagc   1140

tatttatctg tagtaaacta tttatctgtg tttttgaaat attaaaccct ggatcagtcc   1200

tttgatcagt ataatttttt aaagttactt tgtcagaggc acaaaagggt ttaaactgat   1260

tcataataaa tatctgtact tcttcgatct tcaccttttg tgctgtgatt cttcagtttc   1320

taaaccagca ctgtctgggt ccctacaatg tatcaggaag agctgagaat ggtaaggaga   1380

ctcttctaag tcttcatctc agagaccctg agttcccact cagacccact cagccaaatc   1440

tcatggaaga ccaaggaggg cagcactgtt tttgtttttt gttttttgtt tttttttttt   1500

gacactgtcc aaaggttttc catcctgtcc tggaatcaga gttggaagct gaggagcttc   1560

agcctctttt atggtttaat ggccacctgt tctctcctgt gaaaggcttt gcaaagtcac   1620

attaagtttg catgacctgt tatccctggg gccctatttc atagaggctg gccctattag   1680

tgatttccaa aaacaatatg gaagtgcctt ttgatgtctt acaataagag aagaagccaa   1740

tggaaatgaa agagattggc aaaggggaag gatgatgcca tgtagatcct gtttgacatt   1800

tttatggctg tatttgtaaa cttaaacaca ccagtgtctg ttcttgatgc agttgctatt   1860

taggatgagt taagtgcctg gggagtccct caaaaggtta aagggattcc catcattgga   1920

atcttatcac cagataggca agtttatgac caaacaagag agtactggct ttatcctcta   1980

acctcatatt ttctcccact tggcaagtcc tttgtggcat ttattcatca gtcagggtgt   2040

ccgattggtc ctagaacttc caaaggctgc ttgtcataga agccattgca tctataaagc   2100

aacggctcct gttaaatggt atctcctttc tgaggctcct actaaaagtc atttgttacc   2160

taaacttatg tgcttaacag gcaatgcttc tcagaccaca aagcagaaag aagaagaaaa   2220

gctcctgact aaatcagggc tgggcttaga cagagttgat ctgtagaata tctttaaagg   2280

agagatgtca actttctgca ctattcccag cctctgctcc tccctgtcta ccctctcccc   2340

tccctctctc cctccacttc accccacaat cttgaaaaac ttcctttctc ttctgtgaac   2400

atcattggcc agatccattt tcagtggtct ggatttcttt ttattttctt ttcaacttga   2460

aagaaactgg acattaggcc actatgtgtt gttactgcca ctagtgttca agtgcctctt   2520

gttttcccag agatttcctg ggtctgccag aggcccagac aggctcactc aagctcttta   2580

actgaaaagc aacaagccac tccaggacaa ggttcaaaat ggttacaaca gcctctacct   2640

gtcgccccag ggagaaaggg gtagtgatac aagtctcata gccagagatg gttttccact   2700

ccttctagat attcccaaaa agaggctgag acaggaggtt attttcaatt ttattttgga   2760

attaaatact tttttccctt tattactgtt gtagtccctc acttggatat acctctgttt   2820

tcacgataga aataagggag gtctagagct tctattcctt ggccattgtc aacggagagc   2880

tggccaagtc ttcacaaacc cttgcaacat tgcctgaagt ttatggaata agatgtattc   2940

tcactccctt gatctcaagg gcgtaactct ggaagcacag cttgactaca cgtcattttt   3000

accaatgatt ttcaggtgac ctgggctaag tcatttaaac tgggtcttta taaaagtaaa   3060

aggccaacat ttaattattt tgcaaagcaa cctaagagct aaagatgtaa tttttcttgc   3120

aattgtaaat cttttgtgtc tcctgaagac ttcccttaaa attagctctg agtgaaaaat   3180

caaaagagac aaaagacatc ttcgaatcca tatttcaagc ctggtagaat tggcttttct   3240

agcagaacct ttccaaaagt tttatattga gattcataac aacaccaaga attgattttg   3300

tagccaacat tcattcaata ctgttatatc agaggagtag gagagaggaa acatttgact   3360

tatctggaaa agcaaaatgt acttaagaat aagaataaca tggtccattc acctttatgt   3420

tatagatatg tctttgtgta aatcatttgt tttgagtttt caaagaatag cccattgttc   3480

attcttgtgc tgtacaatga ccactgttat tgttactttg acttttcaga gcacaccctt   3540

cctctggttt ttgtatattt attgatggat caataataat gaggaaagca tgatatgtat   3600

attgctgagt tgaaagcact tattggaaaa tattaaaagg ctaacattaa aagactaaag   3660

gaaacaga                                                            3668


<210>  30
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Arg Pro Gly Thr Ala Leu Gln Ala Val Leu Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Gly Leu Arg Ala Ala Thr Gly Arg Leu Leu Ser Ala Ser Asp Leu 
            20                  25                  30          


Asp Leu Arg Gly Gly Gln Pro Val Cys Arg Gly Gly Thr Gln Arg Pro 
        35                  40                  45              


Cys Tyr Lys Val Ile Tyr Phe His Asp Thr Ser Arg Arg Leu Asn Phe 
    50                  55                  60                  


Glu Glu Ala Lys Glu Ala Cys Arg Arg Asp Gly Gly Gln Leu Val Ser 
65                  70                  75                  80  


Ile Glu Ser Glu Asp Glu Gln Lys Leu Ile Glu Lys Phe Ile Glu Asn 
                85                  90                  95      


Leu Leu Pro Ser Asp Gly Asp Phe Trp Ile Gly Leu Arg Arg Arg Glu 
            100                 105                 110         


Glu Lys Gln Ser Asn Ser Thr Ala Cys Gln Asp Leu Tyr Ala Trp Thr 
        115                 120                 125             


Asp Gly Ser Ile Ser Gln Phe Arg Asn Trp Tyr Val Asp Glu Pro Ser 
    130                 135                 140                 


Cys Gly Ser Glu Val Cys Val Val Met Tyr His Gln Pro Ser Ala Pro 
145                 150                 155                 160 


Ala Gly Ile Gly Gly Pro Tyr Met Phe Gln Trp Asn Asp Asp Arg Cys 
                165                 170                 175     


Asn Met Lys Asn Asn Phe Ile Cys Lys Tyr Ser Asp Glu Lys Pro Ala 
            180                 185                 190         


Val Pro Ser Arg Glu Ala Glu Gly Glu Glu Thr Glu Leu Thr Thr Pro 
        195                 200                 205             


Val Leu Pro Glu Glu Thr Gln Glu Glu Asp Ala Lys Lys Thr Phe Lys 
    210                 215                 220                 


Glu Ser Arg Glu Ala Ala Leu Asn Leu Ala Tyr Ile Leu Ile Pro Ser 
225                 230                 235                 240 


Ile Pro Leu Leu Leu Leu Leu Val Val Thr Thr Val Val Cys Trp Val 
                245                 250                 255     


Trp Ile Cys Arg Lys Arg Lys Arg Glu Gln Pro Asp Pro Ser Thr Lys 
            260                 265                 270         


Lys Gln His Thr Ile Trp Pro Ser Pro His Gln Gly Asn Ser Pro Asp 
        275                 280                 285             


Leu Glu Val Tyr Asn Val Ile Arg Lys Gln Ser Glu Ala Asp Leu Ala 
    290                 295                 300                 


Glu Thr Arg Pro Asp Leu Lys Asn Ile Ser Phe Arg Val Cys Ser Gly 
305                 310                 315                 320 


Glu Ala Thr Pro Asp Asp Met Ser Cys Asp Tyr Asp Asn Met Ala Val 
                325                 330                 335     


Asn Pro Ser Glu Ser Gly Phe Val Thr Leu Val Ser Val Glu Ser Gly 
            340                 345                 350         


Phe Val Thr Asn Asp Ile Tyr Glu Phe Ser Pro Asp Gln Met Gly Arg 
        355                 360                 365             


Ser Lys Glu Ser Gly Trp Val Glu Asn Glu Ile Tyr Gly Tyr 
    370                 375                 380         


<210>  31
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Arg Pro Gly Thr Ala Leu Gln Ala Val Leu Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Gly Leu Arg Ala Ala Thr Gly Arg Leu Leu Ser Gly Gln Pro Val 
            20                  25                  30          


Cys Arg Gly Gly Thr Gln Arg Pro Cys Tyr Lys Val Ile Tyr Phe His 
        35                  40                  45              


Asp Thr Ser Arg Arg Leu Asn Phe Glu Glu Ala Lys Glu Ala Cys Arg 
    50                  55                  60                  


Arg Asp Gly Gly Gln Leu Val Ser Ile Glu Ser Glu Asp Glu Gln Lys 
65                  70                  75                  80  


Leu Ile Glu Lys Phe Ile Glu Asn Leu Leu Pro Ser Asp Gly Asp Phe 
                85                  90                  95      


Trp Ile Gly Leu Arg Arg Arg Glu Glu Lys Gln Ser Asn Ser Thr Ala 
            100                 105                 110         


Cys Gln Asp Leu Tyr Ala Trp Thr Asp Gly Ser Ile Ser Gln Phe Arg 
        115                 120                 125             


Asn Trp Tyr Val Asp Glu Pro Ser Cys Gly Ser Glu Val Cys Val Val 
    130                 135                 140                 


Met Tyr His Gln Pro Ser Ala Pro Ala Gly Ile Gly Gly Pro Tyr Met 
145                 150                 155                 160 


Phe Gln Trp Asn Asp Asp Arg Cys Asn Met Lys Asn Asn Phe Ile Cys 
                165                 170                 175     


Lys Tyr Ser Asp Glu Lys Pro Ala Val Pro Ser Arg Glu Ala Glu Gly 
            180                 185                 190         


Glu Glu Thr Glu Leu Thr Thr Pro Val Leu Pro Glu Glu Thr Gln Glu 
        195                 200                 205             


Glu Asp Ala Lys Lys Thr Phe Lys Glu Ser Arg Glu Ala Ala Leu Asn 
    210                 215                 220                 


Leu Ala Tyr Ile Leu Ile Pro Ser Ile Pro Leu Leu Leu Leu Leu Val 
225                 230                 235                 240 


Val Thr Thr Val Val Cys Trp Val Trp Ile Cys Arg Lys Arg Lys Arg 
                245                 250                 255     


Glu Gln Pro Asp Pro Ser Thr Lys Lys Gln His Thr Ile Trp Pro Ser 
            260                 265                 270         


Pro His Gln Gly Asn Ser Pro Asp Leu Glu Val Tyr Asn Val Ile Arg 
        275                 280                 285             


Lys Gln Ser Glu Ala Asp Leu Ala Glu Thr Arg Pro Asp Leu Lys Asn 
    290                 295                 300                 


Ile Ser Phe Arg Val Cys Ser Gly Glu Ala Thr Pro Asp Asp Met Ser 
305                 310                 315                 320 


Cys Asp Tyr Asp Asn Met Ala Val Asn Pro Ser Glu Ser Gly Phe Val 
                325                 330                 335     


Thr Leu Val Ser Val Glu Ser Gly Phe Val Thr Asn Asp Ile Tyr Glu 
            340                 345                 350         


Phe Ser Pro Asp Gln Met Gly Arg Ser Lys Glu Ser Gly Trp Val Glu 
        355                 360                 365             


Asn Glu Ile Tyr Gly Tyr 
    370                 


<210>  32
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Arg Cys Phe Ser Leu Val Leu Leu Leu Thr Ser Ile Trp Thr 
1               5                   10                  15      


Thr Arg Leu Leu Val Gln Gly Ser Leu Arg Ala Glu Glu Leu Ser Ile 
            20                  25                  30          


Gln Val Ser Cys Arg Ile Met Gly Ile Thr Leu Val Ser Lys Lys Ala 
        35                  40                  45              


Asn Gln Gln Leu Asn Phe Thr Glu Ala Lys Glu Ala Cys Arg Leu Leu 
    50                  55                  60                  


Gly Leu Ser Leu Ala Gly Lys Asp Gln Val Glu Thr Ala Leu Lys Ala 
65                  70                  75                  80  


Ser Phe Glu Thr Cys Ser Tyr Gly Trp Val Gly Asp Gly Phe Val Val 
                85                  90                  95      


Ile Ser Arg Ile Ser Pro Asn Pro Lys Cys Gly Lys Asn Gly Val Gly 
            100                 105                 110         


Val Leu Ile Trp Lys Val Pro Val Ser Arg Gln Phe Ala Ala Tyr Cys 
        115                 120                 125             


Tyr Asn Ser Ser Asp Thr Trp Thr Asn Ser Cys Ile Pro Glu Ile Ile 
    130                 135                 140                 


Thr Thr Lys Asp Pro Ile Phe Asn Thr Gln Thr Ala Thr Gln Thr Thr 
145                 150                 155                 160 


Glu Phe Ile Val Ser Asp Ser Thr Tyr Ser Val Ala Ser Pro Tyr Ser 
                165                 170                 175     


Thr Ile Pro Ala Pro Thr Thr Thr Pro Pro Ala Pro Ala Ser Thr Ser 
            180                 185                 190         


Ile Pro Arg Arg Lys Lys Leu Ile Cys Val Thr Glu Val Phe Met Glu 
        195                 200                 205             


Thr Ser Thr Met Ser Thr Glu Thr Glu Pro Phe Val Glu Asn Lys Ala 
    210                 215                 220                 


Ala Phe Lys Asn Glu Ala Ala Gly Phe Gly Gly Val Pro Thr Ala Leu 
225                 230                 235                 240 


Leu Val Leu Ala Leu Leu Phe Phe Gly Ala Ala Ala Gly Leu Gly Phe 
                245                 250                 255     


Cys Tyr Val Lys Arg Tyr Val Lys Ala Phe Pro Phe Thr Asn Lys Asn 
            260                 265                 270         


Gln Gln Lys Glu Met Ile Glu Thr Lys Val Val Lys Glu Glu Lys Ala 
        275                 280                 285             


Asn Asp Ser Asn Pro Asn Glu Glu Ser Lys Lys Thr Asp Lys Asn Pro 
    290                 295                 300                 


Glu Glu Ser Lys Ser Pro Ser Lys Thr Thr Val Arg Cys Leu Glu Ala 
305                 310                 315                 320 


Glu Val 
        


<210>  33
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Phe Pro Lys Ala Pro Leu Lys Arg Phe Asn Asp Pro Ser Gly 
1               5                   10                  15      


Cys Ala Pro Ser Pro Gly Ala Tyr Asp Val Lys Thr Leu Glu Val Leu 
            20                  25                  30          


Lys Gly Pro Val Ser Phe Gln Lys Ser Gln Arg Phe Lys Gln Gln Lys 
        35                  40                  45              


Glu Ser Lys Gln Asn Leu Asn Val Asp Lys Asp Thr Thr Leu Pro Ala 
    50                  55                  60                  


Ser Ala Arg Lys Val Lys Ser Ser Glu Ser Lys Glu Ser Gln Lys Asn 
65                  70                  75                  80  


Asp Lys Asp Leu Lys Ile Leu Glu Lys Glu Ile Arg Val Leu Leu Gln 
                85                  90                  95      


Glu Arg Gly Ala Gln Asp Arg Arg Ile Gln Asp Leu Glu Thr Glu Leu 
            100                 105                 110         


Glu Lys Met Glu Ala Arg Leu Asn Ala Ala Leu Arg Glu Lys Thr Ser 
        115                 120                 125             


Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln Leu Ile Glu Leu Thr 
    130                 135                 140                 


Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe Ser Glu Asn Gly Asn Gln 
145                 150                 155                 160 


Lys Asn Leu Arg Ile Leu Ser Leu Glu Leu Met Lys Leu Arg Asn Lys 
                165                 170                 175     


Arg Glu Thr Lys Met Arg Gly Met Met Ala Lys Gln Glu Gly Met Glu 
            180                 185                 190         


Met Lys Leu Gln Val Thr Gln Arg Ser Leu Glu Glu Ser Gln Gly Lys 
        195                 200                 205             


Ile Ala Gln Leu Glu Gly Lys Leu Val Ser Ile Glu Lys Glu Lys Ile 
    210                 215                 220                 


Asp Glu Lys Ser Glu Thr Glu Lys Leu Leu Glu Tyr Ile Glu Glu Ile 
225                 230                 235                 240 


Ser Cys Ala Ser Asp Gln Val Glu Lys Tyr Lys Leu Asp Ile Ala Gln 
                245                 250                 255     


Leu Glu Glu Asn Leu Lys Glu Lys Asn Asp Glu Ile Leu Ser Leu Lys 
            260                 265                 270         


Gln Ser Leu Glu Glu Asn Ile Val Ile Leu Ser Lys Gln Val Glu Asp 
        275                 280                 285             


Leu Asn Val Lys Cys Gln Leu Leu Glu Lys Glu Lys Glu Asp His Val 
    290                 295                 300                 


Asn Arg Asn Arg Glu His Asn Glu Asn Leu Asn Ala Glu Met Gln Asn 
305                 310                 315                 320 


Leu Lys Gln Lys Phe Ile Leu Glu Gln Gln Glu Arg Glu Lys Leu Gln 
                325                 330                 335     


Gln Lys Glu Leu Gln Ile Asp Ser Leu Leu Gln Gln Glu Lys Glu Leu 
            340                 345                 350         


Ser Ser Ser Leu His Gln Lys Leu Cys Ser Phe Gln Glu Glu Met Val 
        355                 360                 365             


Lys Glu Lys Asn Leu Phe Glu Glu Glu Leu Lys Gln Thr Leu Asp Glu 
    370                 375                 380                 


Leu Asp Lys Leu Gln Gln Lys Glu Glu Gln Ala Glu Arg Leu Val Lys 
385                 390                 395                 400 


Gln Leu Glu Glu Glu Ala Lys Ser Arg Ala Glu Glu Leu Lys Leu Leu 
                405                 410                 415     


Glu Glu Lys Leu Lys Gly Lys Glu Ala Glu Leu Glu Lys Ser Ser Ala 
            420                 425                 430         


Ala His Thr Gln Ala Thr Leu Leu Leu Gln Glu Lys Tyr Asp Ser Met 
        435                 440                 445             


Val Gln Ser Leu Glu Asp Val Thr Ala Gln Phe Glu Ser Tyr Lys Ala 
    450                 455                 460                 


Leu Thr Ala Ser Glu Ile Glu Asp Leu Lys Leu Glu Asn Ser Ser Leu 
465                 470                 475                 480 


Gln Glu Lys Ala Ala Lys Ala Gly Lys Asn Ala Glu Asp Val Gln His 
                485                 490                 495     


Gln Ile Leu Ala Thr Glu Ser Ser Asn Gln Glu Tyr Val Arg Met Leu 
            500                 505                 510         


Leu Asp Leu Gln Thr Lys Ser Ala Leu Lys Glu Thr Glu Ile Lys Glu 
        515                 520                 525             


Ile Thr Val Ser Phe Leu Gln Lys Ile Thr Asp Leu Gln Asn Gln Leu 
    530                 535                 540                 


Lys Gln Gln Glu Glu Asp Phe Arg Lys Gln Leu Glu Asp Glu Glu Gly 
545                 550                 555                 560 


Arg Lys Ala Glu Lys Glu Asn Thr Thr Ala Glu Leu Thr Glu Glu Ile 
                565                 570                 575     


Asn Lys Trp Arg Leu Leu Tyr Glu Glu Leu Tyr Asn Lys Thr Lys Pro 
            580                 585                 590         


Phe Gln Leu Gln Leu Asp Ala Phe Glu Val Glu Lys Gln Ala Leu Leu 
        595                 600                 605             


Asn Glu His Gly Ala Ala Gln Glu Gln Leu Asn Lys Ile Arg Asp Ser 
    610                 615                 620                 


Tyr Ala Lys Leu Leu Gly His Gln Asn Leu Lys Gln Lys Ile Lys His 
625                 630                 635                 640 


Val Val Lys Leu Lys Asp Glu Asn Ser Gln Leu Lys Ser Glu Val Ser 
                645                 650                 655     


Lys Leu Arg Cys Gln Leu Ala Lys Lys Lys Gln Ser Glu Thr Lys Leu 
            660                 665                 670         


Gln Glu Glu Leu Asn Lys Val Leu Gly Ile Lys His Phe Asp Pro Ser 
        675                 680                 685             


Lys Ala Phe His His Glu Ser Lys Glu Asn Phe Ala Leu Lys Thr Pro 
    690                 695                 700                 


Leu Lys Glu Gly Asn Thr Asn Cys Tyr Arg Ala Pro Met Glu Cys Gln 
705                 710                 715                 720 


Glu Ser Trp Lys 
                


<210>  34
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ser Phe Pro Lys Ala Pro Leu Lys Arg Phe Asn Asp Pro Ser Gly 
1               5                   10                  15      


Cys Ala Pro Ser Pro Gly Ala Tyr Asp Val Lys Thr Leu Glu Val Leu 
            20                  25                  30          


Lys Gly Pro Val Ser Phe Gln Lys Ser Gln Arg Phe Lys Gln Gln Lys 
        35                  40                  45              


Glu Ser Lys Gln Asn Leu Asn Val Asp Lys Asp Thr Thr Leu Pro Ala 
    50                  55                  60                  


Ser Ala Arg Lys Val Lys Ser Ser Glu Ser Lys Ile Arg Val Leu Leu 
65                  70                  75                  80  


Gln Glu Arg Gly Ala Gln Asp Arg Arg Ile Gln Asp Leu Glu Thr Glu 
                85                  90                  95      


Leu Glu Lys Met Glu Ala Arg Leu Asn Ala Ala Leu Arg Glu Lys Thr 
            100                 105                 110         


Ser Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln Leu Ile Glu Leu 
        115                 120                 125             


Thr Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe Ser Glu Asn Gly Asn 
    130                 135                 140                 


Gln Lys Asn Leu Arg Ile Leu Ser Leu Glu Leu Met Lys Leu Arg Asn 
145                 150                 155                 160 


Lys Arg Glu Thr Lys Met Arg Gly Met Met Ala Lys Gln Glu Gly Met 
                165                 170                 175     


Glu Met Lys Leu Gln Val Thr Gln Arg Ser Leu Glu Glu Ser Gln Gly 
            180                 185                 190         


Lys Ile Ala Gln Leu Glu Gly Lys Leu Val Ser Ile Glu Lys Glu Lys 
        195                 200                 205             


Ile Asp Glu Lys Ser Glu Thr Glu Lys Leu Leu Glu Tyr Ile Glu Glu 
    210                 215                 220                 


Ile Ser Cys Ala Ser Asp Gln Val Glu Lys Tyr Lys Leu Asp Ile Ala 
225                 230                 235                 240 


Gln Leu Glu Glu Asn Leu Lys Glu Lys Asn Asp Glu Ile Leu Ser Leu 
                245                 250                 255     


Lys Gln Ser Leu Glu Glu Asn Ile Val Ile Leu Ser Lys Gln Val Glu 
            260                 265                 270         


Asp Leu Asn Val Lys Cys Gln Leu Leu Glu Lys Glu Lys Glu Asp His 
        275                 280                 285             


Val Asn Arg Asn Arg Glu His Asn Glu Asn Leu Asn Ala Glu Met Gln 
    290                 295                 300                 


Asn Leu Lys Gln Lys Phe Ile Leu Glu Gln Gln Glu Arg Glu Lys Leu 
305                 310                 315                 320 


Gln Gln Lys Glu Leu Gln Ile Asp Ser Leu Leu Gln Gln Glu Lys Glu 
                325                 330                 335     


Leu Ser Ser Ser Leu His Gln Lys Leu Cys Ser Phe Gln Glu Glu Met 
            340                 345                 350         


Val Lys Glu Lys Asn Leu Phe Glu Glu Glu Leu Lys Gln Thr Leu Asp 
        355                 360                 365             


Glu Leu Asp Lys Leu Gln Gln Lys Glu Glu Gln Ala Glu Arg Leu Val 
    370                 375                 380                 


Lys Gln Leu Glu Glu Glu Ala Lys Ser Arg Ala Glu Glu Leu Lys Leu 
385                 390                 395                 400 


Leu Glu Glu Lys Leu Lys Gly Lys Glu Ala Glu Leu Glu Lys Ser Ser 
                405                 410                 415     


Ala Ala His Thr Gln Ala Thr Leu Leu Leu Gln Glu Lys Tyr Asp Ser 
            420                 425                 430         


Met Val Gln Ser Leu Glu Asp Val Thr Ala Gln Phe Glu Ser Tyr Lys 
        435                 440                 445             


Ala Leu Thr Ala Ser Glu Ile Glu Asp Leu Lys Leu Glu Asn Ser Ser 
    450                 455                 460                 


Leu Gln Glu Lys Ala Ala Lys Ala Gly Lys Asn Ala Glu Asp Val Gln 
465                 470                 475                 480 


His Gln Ile Leu Ala Thr Glu Ser Ser Asn Gln Glu Tyr Val Arg Met 
                485                 490                 495     


Leu Leu Asp Leu Gln Thr Lys Ser Ala Leu Lys Glu Thr Glu Ile Lys 
            500                 505                 510         


Glu Ile Thr Val Ser Phe Leu Gln Lys Ile Thr Asp Leu Gln Asn Gln 
        515                 520                 525             


Leu Lys Gln Gln Glu Glu Asp Phe Arg Lys Gln Leu Glu Asp Glu Glu 
    530                 535                 540                 


Gly Arg Lys Ala Glu Lys Glu Asn Thr Thr Ala Glu Leu Thr Glu Glu 
545                 550                 555                 560 


Ile Asn Lys Trp Arg Leu Leu Tyr Glu Glu Leu Tyr Asn Lys Thr Lys 
                565                 570                 575     


Pro Phe Gln Leu Gln Leu Asp Ala Phe Glu Val Glu Lys Gln Ala Leu 
            580                 585                 590         


Leu Asn Glu His Gly Ala Ala Gln Glu Gln Leu Asn Lys Ile Arg Asp 
        595                 600                 605             


Ser Tyr Ala Lys Leu Leu Gly His Gln Asn Leu Lys Gln Lys Ile Lys 
    610                 615                 620                 


His Val Val Lys Leu Lys Asp Glu Asn Ser Gln Leu Lys Ser Glu Val 
625                 630                 635                 640 


Ser Lys Leu Arg Cys Gln Leu Ala Lys Lys Lys Gln Ser Glu Thr Lys 
                645                 650                 655     


Leu Gln Glu Glu Leu Asn Lys Val Leu Gly Ile Lys His Phe Asp Pro 
            660                 665                 670         


Ser Lys Ala Phe His His Glu Ser Lys Glu Asn Phe Ala Leu Lys Thr 
        675                 680                 685             


Pro Leu Lys Glu Gly Asn Thr Asn Cys Tyr Arg Ala Pro Met Glu Cys 
    690                 695                 700                 


Gln Glu Ser Trp Lys 
705                 


<210>  35
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Arg Gln Asp Ala Pro Lys Pro Thr Pro Ala Ala Cys Arg Cys Ser 
1               5                   10                  15      


Gly Leu Ala Arg Arg Val Leu Thr Ile Ala Phe Ala Leu Leu Ile Leu 
            20                  25                  30          


Gly Leu Met Thr Trp Ala Tyr Ala Ala Gly Val Pro Leu Ala Ser Asp 
        35                  40                  45              


Arg Tyr Gly Leu Leu Ala Phe Gly Leu Tyr Gly Ala Phe Leu Ser Ala 
    50                  55                  60                  


His Leu Val Ala Gln Ser Leu Phe Ala Tyr Leu Glu His Arg Arg Val 
65                  70                  75                  80  


Ala Ala Ala Ala Arg Gly Pro Leu Asp Ala Ala Thr Ala Arg Ser Val 
                85                  90                  95      


Ala Leu Thr Ile Ser Ala Tyr Gln Glu Asp Pro Ala Tyr Leu Arg Gln 
            100                 105                 110         


Cys Leu Ala Ser Ala Arg Ala Leu Leu Tyr Pro Arg Ala Arg Leu Arg 
        115                 120                 125             


Val Leu Met Val Val Asp Gly Asn Arg Ala Glu Asp Leu Tyr Met Val 
    130                 135                 140                 


Asp Met Phe Arg Glu Val Phe Ala Asp Glu Asp Pro Ala Thr Tyr Val 
145                 150                 155                 160 


Trp Asp Gly Asn Tyr His Gln Pro Trp Glu Pro Ala Ala Ala Gly Ala 
                165                 170                 175     


Val Gly Ala Gly Ala Tyr Arg Glu Val Glu Ala Glu Asp Pro Gly Arg 
            180                 185                 190         


Leu Ala Val Glu Ala Leu Val Arg Thr Arg Arg Cys Val Cys Val Ala 
        195                 200                 205             


Gln Arg Trp Gly Gly Lys Arg Glu Val Met Tyr Thr Ala Phe Lys Ala 
    210                 215                 220                 


Leu Gly Asp Ser Val Asp Tyr Val Gln Val Cys Asp Ser Asp Thr Arg 
225                 230                 235                 240 


Leu Asp Pro Met Ala Leu Leu Glu Leu Val Arg Val Leu Asp Glu Asp 
                245                 250                 255     


Pro Arg Val Gly Ala Val Gly Gly Asp Val Arg Ile Leu Asn Pro Leu 
            260                 265                 270         


Asp Ser Trp Val Ser Phe Leu Ser Ser Leu Arg Tyr Trp Val Ala Phe 
        275                 280                 285             


Asn Val Glu Arg Ala Cys Gln Ser Tyr Phe His Cys Val Ser Cys Ile 
    290                 295                 300                 


Ser Gly Pro Leu Gly Leu Tyr Arg Asn Asn Leu Leu Gln Gln Phe Leu 
305                 310                 315                 320 


Glu Ala Trp Tyr Asn Gln Lys Phe Leu Gly Thr His Cys Thr Phe Gly 
                325                 330                 335     


Asp Asp Arg His Leu Thr Asn Arg Met Leu Ser Met Gly Tyr Ala Thr 
            340                 345                 350         


Lys Tyr Thr Ser Arg Ser Arg Cys Tyr Ser Glu Thr Pro Ser Ser Phe 
        355                 360                 365             


Leu Arg Trp Leu Ser Gln Gln Thr Arg Trp Ser Lys Ser Tyr Phe Arg 
    370                 375                 380                 


Glu Trp Leu Tyr Asn Ala Leu Trp Trp His Arg His His Ala Trp Met 
385                 390                 395                 400 


Thr Tyr Glu Ala Val Val Ser Gly Leu Phe Pro Phe Phe Val Ala Ala 
                405                 410                 415     


Thr Val Leu Arg Leu Phe Tyr Ala Gly Arg Pro Trp Ala Leu Leu Trp 
            420                 425                 430         


Val Leu Leu Cys Val Gln Gly Val Ala Leu Ala Lys Ala Ala Phe Ala 
        435                 440                 445             


Ala Trp Leu Arg Gly Cys Leu Arg Met Val Leu Leu Ser Leu Tyr Ala 
    450                 455                 460                 


Pro Leu Tyr Met Cys Gly Leu Leu Pro Ala Lys Phe Leu Ala Leu Val 
465                 470                 475                 480 


Thr Met Asn Gln Ser Gly Trp Gly Thr Ser Gly Arg Arg Lys Leu Ala 
                485                 490                 495     


Ala Asn Tyr Val Pro Leu Leu Pro Leu Ala Leu Trp Ala Leu Leu Leu 
            500                 505                 510         


Leu Gly Gly Leu Val Arg Ser Val Ala His Glu Ala Arg Ala Asp Trp 
        515                 520                 525             


Ser Gly Pro Ser Arg Ala Ala Glu Ala Tyr His Leu Ala Ala Gly Ala 
    530                 535                 540                 


Gly Ala Tyr Val Gly Tyr Trp Val Ala Met Leu Thr Leu Tyr Trp Val 
545                 550                 555                 560 


Gly Val Arg Arg Leu Cys Arg Arg Arg Thr Gly Gly Tyr Arg Val Gln 
                565                 570                 575     


Val 
    


<210>  36
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Arg Gln Gln Asp Ala Pro Lys Pro Thr Pro Ala Ala Cys Arg Cys 
1               5                   10                  15      


Ser Gly Leu Ala Arg Arg Val Leu Thr Ile Ala Phe Ala Leu Leu Ile 
            20                  25                  30          


Leu Gly Leu Met Thr Trp Ala Tyr Ala Ala Gly Val Pro Leu Ala Ser 
        35                  40                  45              


Asp Arg Tyr Gly Leu Leu Ala Phe Gly Leu Tyr Gly Ala Phe Leu Ser 
    50                  55                  60                  


Ala His Leu Val Ala Gln Ser Leu Phe Ala Tyr Leu Glu His Arg Arg 
65                  70                  75                  80  


Val Ala Ala Ala Ala Arg Gly Pro Leu Asp Ala Ala Thr Ala Arg Ser 
                85                  90                  95      


Val Ala Leu Thr Ile Ser Ala Tyr Gln Glu Asp Pro Ala Tyr Leu Arg 
            100                 105                 110         


Gln Cys Leu Ala Ser Ala Arg Ala Leu Leu Tyr Pro Arg Ala Arg Leu 
        115                 120                 125             


Arg Val Leu Met Val Val Asp Gly Asn Arg Ala Glu Asp Leu Tyr Met 
    130                 135                 140                 


Val Asp Met Phe Arg Glu Val Phe Ala Asp Glu Asp Pro Ala Thr Tyr 
145                 150                 155                 160 


Val Trp Asp Gly Asn Tyr His Gln Pro Trp Glu Pro Ala Ala Ala Gly 
                165                 170                 175     


Ala Val Gly Ala Gly Ala Tyr Arg Glu Val Glu Ala Glu Asp Pro Gly 
            180                 185                 190         


Arg Leu Ala Val Glu Ala Leu Val Arg Thr Arg Arg Cys Val Cys Val 
        195                 200                 205             


Ala Gln Arg Trp Gly Gly Lys Arg Glu Val Met Tyr Thr Ala Phe Lys 
    210                 215                 220                 


Ala Leu Gly Asp Ser Val Asp Tyr Val Gln Val Cys Asp Ser Asp Thr 
225                 230                 235                 240 


Arg Leu Asp Pro Met Ala Leu Leu Glu Leu Val Arg Val Leu Asp Glu 
                245                 250                 255     


Asp Pro Arg Val Gly Ala Val Gly Gly Asp Val Arg Ile Leu Asn Pro 
            260                 265                 270         


Leu Asp Ser Trp Val Ser Phe Leu Ser Ser Leu Arg Tyr Trp Val Ala 
        275                 280                 285             


Phe Asn Val Glu Arg Ala Cys Gln Ser Tyr Phe His Cys Val Ser Cys 
    290                 295                 300                 


Ile Ser Gly Pro Leu Gly Leu Tyr Arg Asn Asn Leu Leu Gln Gln Phe 
305                 310                 315                 320 


Leu Glu Ala Trp Tyr Asn Gln Lys Phe Leu Gly Thr His Cys Thr Phe 
                325                 330                 335     


Gly Asp Asp Arg His Leu Thr Asn Arg Met Leu Ser Met Gly Tyr Ala 
            340                 345                 350         


Thr Lys Tyr Thr Ser Arg Ser Arg Cys Tyr Ser Glu Thr Pro Ser Ser 
        355                 360                 365             


Phe Leu Arg Trp Leu Ser Gln Gln Thr Arg Trp Ser Lys Ser Tyr Phe 
    370                 375                 380                 


Arg Glu Trp Leu Tyr Asn Ala Leu Trp Trp His Arg His His Ala Trp 
385                 390                 395                 400 


Met Thr Tyr Glu Ala Val Val Ser Gly Leu Phe Pro Phe Phe Val Ala 
                405                 410                 415     


Ala Thr Val Leu Arg Leu Phe Tyr Ala Gly Arg Pro Trp Ala Leu Leu 
            420                 425                 430         


Trp Val Leu Leu Cys Val Gln Gly Val Ala Leu Ala Lys Ala Ala Phe 
        435                 440                 445             


Ala Ala Trp Leu Arg Gly Cys Leu Arg Met Val Leu Leu Ser Leu Tyr 
    450                 455                 460                 


Ala Pro Leu Tyr Met Cys Gly Leu Leu Pro Ala Lys Phe Leu Ala Leu 
465                 470                 475                 480 


Val Thr Met Asn Gln Ser Gly Trp Gly Thr Ser Gly Arg Arg Lys Leu 
                485                 490                 495     


Ala Ala Asn Tyr Val Pro Leu Leu Pro Leu Ala Leu Trp Ala Leu Leu 
            500                 505                 510         


Leu Leu Gly Gly Leu Val Arg Ser Val Ala His Glu Ala Arg Ala Asp 
        515                 520                 525             


Trp Ser Gly Pro Ser Arg Ala Ala Glu Ala Tyr His Leu Ala Ala Gly 
    530                 535                 540                 


Ala Gly Ala Tyr Val Gly Tyr Trp Val Ala Met Leu Thr Leu Tyr Trp 
545                 550                 555                 560 


Val Gly Val Arg Arg Leu Cys Arg Arg Arg Thr Gly Gly Tyr Arg Val 
                565                 570                 575     


Gln Val 
        


<210>  37
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  37

Met His Cys Glu Arg Phe Leu Cys Ile Leu Arg Ile Ile Gly Thr Thr 
1               5                   10                  15      


Leu Phe Gly Val Ser Leu Leu Leu Gly Ile Thr Ala Ala Tyr Ile Val 
            20                  25                  30          


Gly Tyr Gln Phe Ile Gln Thr Asp Asn Tyr Tyr Phe Ser Phe Gly Leu 
        35                  40                  45              


Tyr Gly Ala Phe Leu Ala Ser His Leu Ile Ile Gln Ser Leu Phe Ala 
    50                  55                  60                  


Phe Leu Glu His Arg Lys Met Lys Lys Ser Leu Glu Thr Pro Ile Lys 
65                  70                  75                  80  


Leu Asn Lys Thr Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu Asp Pro 
                85                  90                  95      


Asp Tyr Leu Arg Lys Cys Leu Gln Ser Val Lys Arg Leu Thr Tyr Pro 
            100                 105                 110         


Gly Ile Lys Val Val Met Val Ile Asp Gly Asn Ser Glu Asp Asp Leu 
        115                 120                 125             


Tyr Met Met Asp Ile Phe Ser Glu Val Met Gly Arg Asp Lys Ser Ala 
    130                 135                 140                 


Thr Tyr Ile Trp Lys Asn Asn Phe His Glu Lys Gly Pro Gly Glu Thr 
145                 150                 155                 160 


Asp Glu Ser His Lys Glu Ser Ser Gln His Val Thr Gln Leu Val Leu 
                165                 170                 175     


Ser Asn Lys Ser Ile Cys Ile Met Gln Lys Trp Gly Gly Lys Arg Glu 
            180                 185                 190         


Val Met Tyr Thr Ala Phe Arg Ala Leu Gly Arg Ser Val Asp Tyr Val 
        195                 200                 205             


Gln Val Cys Asp Ser Asp Thr Met Leu Asp Pro Ala Ser Ser Val Glu 
    210                 215                 220                 


Met Val Lys Val Leu Glu Glu Asp Pro Met Val Gly Gly Val Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ile Leu Asn Lys Tyr Asp Ser Trp Ile Ser Phe Leu Ser 
                245                 250                 255     


Ser Val Arg Tyr Trp Met Ala Phe Asn Ile Glu Arg Ala Cys Gln Ser 
            260                 265                 270         


Tyr Phe Gly Cys Val Gln Cys Ile Ser Gly Pro Leu Gly Met Tyr Arg 
        275                 280                 285             


Asn Ser Leu Leu His Glu Phe Val Glu Asp Trp Tyr Asn Gln Glu Phe 
    290                 295                 300                 


Met Gly Asn Gln Cys Ser Phe Gly Asp Asp Arg His Leu Thr Asn Arg 
305                 310                 315                 320 


Val Leu Ser Leu Gly Tyr Ala Thr Lys Tyr Thr Ala Arg Ser Lys Cys 
                325                 330                 335     


Leu Thr Glu Thr Pro Ile Glu Tyr Leu Arg Trp Leu Asn Gln Gln Thr 
            340                 345                 350         


Arg Trp Ser Lys Ser Tyr Phe Arg Glu Trp Leu Tyr Asn Ala Met Trp 
        355                 360                 365             


Phe His Lys His His Leu Trp Met Thr Tyr Glu Ala Ile Ile Thr Gly 
    370                 375                 380                 


Phe Phe Pro Phe Phe Leu Ile Ala Thr Val Ile Gln Leu Phe Tyr Arg 
385                 390                 395                 400 


Gly Lys Ile Trp Asn Ile Leu Leu Phe Leu Leu Thr Val Gln Leu Val 
                405                 410                 415     


Gly Leu Ile Lys Ser Ser Phe Ala Ser Cys Leu Arg Gly Asn Ile Val 
            420                 425                 430         


Met Val Phe Met Ser Leu Tyr Ser Val Leu Tyr Met Ser Ser Leu Leu 
        435                 440                 445             


Pro Ala Lys Met Phe Ala Ile Ala Thr Ile Asn Lys Ala Gly Trp Gly 
    450                 455                 460                 


Thr Ser Gly Arg Lys Thr Ile Val Val Asn Phe Ile Gly Leu Ile Pro 
465                 470                 475                 480 


Val Ser Val Trp Phe Thr Ile Leu Leu Gly Gly Val Ile Phe Thr Ile 
                485                 490                 495     


Tyr Lys Glu Ser Lys Arg Pro Phe Ser Glu Ser Lys Gln Thr Val Leu 
            500                 505                 510         


Ile Val Gly Thr Leu Leu Tyr Ala Cys Tyr Trp Val Met Leu Leu Thr 
        515                 520                 525             


Leu Tyr Val Val Leu Ile Asn Lys Cys Gly Arg Arg Lys Lys Gly Gln 
    530                 535                 540                 


Gln Tyr Asp Met Val Leu Asp Val 
545                 550         


<210>  38
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Pro Val Gln Leu Thr Thr Ala Leu Arg Val Val Gly Thr Ser Leu 
1               5                   10                  15      


Phe Ala Leu Ala Val Leu Gly Gly Ile Leu Ala Ala Tyr Val Thr Gly 
            20                  25                  30          


Tyr Gln Phe Ile His Thr Glu Lys His Tyr Leu Ser Phe Gly Leu Tyr 
        35                  40                  45              


Gly Ala Ile Leu Gly Leu His Leu Leu Ile Gln Ser Leu Phe Ala Phe 
    50                  55                  60                  


Leu Glu His Arg Arg Met Arg Arg Ala Gly Gln Ala Leu Lys Leu Pro 
65                  70                  75                  80  


Ser Pro Arg Arg Gly Ser Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu 
                85                  90                  95      


Asp Pro Asp Tyr Leu Arg Lys Cys Leu Arg Ser Ala Gln Arg Ile Ser 
            100                 105                 110         


Phe Pro Asp Leu Lys Val Val Met Val Val Asp Gly Asn Arg Gln Glu 
        115                 120                 125             


Asp Ala Tyr Met Leu Asp Ile Phe His Glu Val Leu Gly Gly Thr Glu 
    130                 135                 140                 


Gln Ala Gly Phe Phe Val Trp Arg Ser Asn Phe His Glu Ala Gly Glu 
145                 150                 155                 160 


Gly Glu Thr Glu Ala Ser Leu Gln Glu Gly Met Asp Arg Val Arg Asp 
                165                 170                 175     


Val Val Arg Ala Ser Thr Phe Ser Cys Ile Met Gln Lys Trp Gly Gly 
            180                 185                 190         


Lys Arg Glu Val Met Tyr Thr Ala Phe Lys Ala Leu Gly Asp Ser Val 
        195                 200                 205             


Asp Tyr Ile Gln Val Cys Asp Ser Asp Thr Val Leu Asp Pro Ala Cys 
    210                 215                 220                 


Thr Ile Glu Met Leu Arg Val Leu Glu Glu Asp Pro Gln Val Gly Gly 
225                 230                 235                 240 


Val Gly Gly Asp Val Gln Ile Leu Asn Lys Tyr Asp Ser Trp Ile Ser 
                245                 250                 255     


Phe Leu Ser Ser Val Arg Tyr Trp Met Ala Phe Asn Val Glu Arg Ala 
            260                 265                 270         


Cys Gln Ser Tyr Phe Gly Cys Val Gln Cys Ile Ser Gly Pro Leu Gly 
        275                 280                 285             


Met Tyr Arg Asn Ser Leu Leu Gln Gln Phe Leu Glu Asp Trp Tyr His 
    290                 295                 300                 


Gln Lys Phe Leu Gly Ser Lys Cys Ser Phe Gly Asp Asp Arg His Leu 
305                 310                 315                 320 


Thr Asn Arg Val Leu Ser Leu Gly Tyr Arg Thr Lys Tyr Thr Ala Arg 
                325                 330                 335     


Ser Lys Cys Leu Thr Glu Thr Pro Thr Lys Tyr Leu Arg Trp Leu Asn 
            340                 345                 350         


Gln Gln Thr Arg Trp Ser Lys Ser Tyr Phe Arg Glu Trp Leu Tyr Asn 
        355                 360                 365             


Ser Leu Trp Phe His Lys His His Leu Trp Met Thr Tyr Glu Ser Val 
    370                 375                 380                 


Val Thr Gly Phe Phe Pro Phe Phe Leu Ile Ala Thr Val Ile Gln Leu 
385                 390                 395                 400 


Phe Tyr Arg Gly Arg Ile Trp Asn Ile Leu Leu Phe Leu Leu Thr Val 
                405                 410                 415     


Gln Leu Val Gly Ile Ile Lys Ala Thr Tyr Ala Cys Phe Leu Arg Gly 
            420                 425                 430         


Asn Ala Glu Met Ile Phe Met Ser Leu Tyr Ser Leu Leu Tyr Met Ser 
        435                 440                 445             


Ser Leu Leu Pro Ala Lys Ile Phe Ala Ile Ala Thr Ile Asn Lys Ser 
    450                 455                 460                 


Gly Trp Gly Thr Ser Gly Arg Lys Thr Ile Val Val Asn Phe Ile Gly 
465                 470                 475                 480 


Leu Ile Pro Val Ser Ile Trp Val Ala Val Leu Leu Gly Gly Leu Ala 
                485                 490                 495     


Tyr Thr Ala Tyr Cys Gln Asp Leu Phe Ser Glu Thr Glu Leu Ala Phe 
            500                 505                 510         


Leu Val Ser Gly Ala Ile Leu Tyr Gly Cys Tyr Trp Val Ala Leu Leu 
        515                 520                 525             


Met Leu Tyr Leu Ala Ile Ile Ala Arg Arg Cys Gly Lys Lys Pro Glu 
    530                 535                 540                 


Gln Tyr Ser Leu Ala Phe Ala Glu Val 
545                 550             


<210>  39
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Pro Val Gln Leu Thr Thr Ala Leu Arg Val Val Gly Thr Ser Leu 
1               5                   10                  15      


Phe Ala Leu Ala Val Leu Gly Gly Ile Leu Ala Ala Tyr Val Thr Gly 
            20                  25                  30          


Tyr Gln Phe Ile His Thr Glu Lys His Tyr Leu Ser Phe Gly Leu Tyr 
        35                  40                  45              


Gly Ala Ile Leu Gly Leu His Leu Leu Ile Gln Ser Leu Phe Ala Phe 
    50                  55                  60                  


Leu Glu His Arg Arg Met Arg Arg Ala Gly Gln Ala Leu Lys Leu Pro 
65                  70                  75                  80  


Ser Pro Arg Arg Gly Ser Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu 
                85                  90                  95      


Asp Pro Asp Tyr Leu Arg Lys Cys Leu Arg Ser Ala Gln Arg Ile Ser 
            100                 105                 110         


Phe Pro Asp Leu Lys Val Val Met Val Val Asp Gly Asn Arg Gln Glu 
        115                 120                 125             


Asp Ala Tyr Met Leu Asp Ile Phe His Glu Val Leu Gly Gly Thr Glu 
    130                 135                 140                 


Gln Ala Gly Phe Phe Val Trp Arg Ser Asn Phe His Glu Ala Gly Glu 
145                 150                 155                 160 


Gly Glu Thr Glu Ala Ser Leu Gln Glu Gly Met Asp Arg Val Arg Asp 
                165                 170                 175     


Val Val Arg Ala Ser Thr Phe Ser Cys Ile Met Gln Lys Trp Gly Gly 
            180                 185                 190         


Lys Arg Glu Val Met Tyr Thr Ala Phe Lys Ala Leu Gly Asp Ser Val 
        195                 200                 205             


Asp Tyr Ile Gln Val Cys Asp Ser Asp Thr Val Leu Asp Pro Ala Cys 
    210                 215                 220                 


Thr Ile Glu Met Leu Arg Val Leu Glu Glu Asp Pro Gln Val Gly Gly 
225                 230                 235                 240 


Val Gly Gly Asp Val Gln Pro Pro Gly Lys Gly Met Ala Val Glu Asp 
                245                 250                 255     


Asp Gln Val Gln Ala Ala Gln Val Arg Ala Thr Glu Ala Trp Ser Val 
            260                 265                 270         


His Gln Arg His Val Ser Arg Glu Gln 
        275                 280     


<210>  40
<211>  2107
<212>  DNA
<213>  Homo sapiens

<400>  40
acagagaggc tgggagagca agccggagag aagagagagc ccggccagac ccactgcgat     60

gagacaggac gcgcccaagc ccactcctgc agcctgccgc tgctccggcc tggcccggag    120

ggtgctgacc atcgccttcg ccctgctcat cctgggcctc atgacctggg cctacgccgc    180

cggggtgccg ctggcctccg atcgctacgg cctcctggcc ttcggcctct acggggcctt    240

cctttcagcg cacctggtgg cgcagagcct cttcgcgtac ctggagcacc ggcgggtggc    300

ggcggcggcg cgggggccgc tggatgcagc caccgcgcgc agtgtggcgc tgaccatctc    360

cgcctaccag gaggaccccg cgtacctgcg ccagtgcctg gcgtccgccc gcgccctgct    420

gtacccgcgc gcgcggctgc gcgtcctcat ggtggtggat ggcaaccgcg ccgaggacct    480

ctacatggtc gacatgttcc gcgaggtctt cgctgacgag gaccccgcca cgtacgtgtg    540

ggacggcaac taccaccagc cctgggaacc cgcggcggcg ggcgcggtgg gcgccggagc    600

ctatcgggag gtggaggcgg aggatcctgg gcggctggca gtggaggcgc tggtgaggac    660

tcgcaggtgc gtgtgcgtgg cgcagcgctg gggcggcaag cgcgaggtca tgtacacagc    720

cttcaaggcg ctcggagatt cggtggacta cgtgcaggtc tgtgactcgg acacaaggtt    780

ggaccccatg gcactgctgg agctcgtgcg ggtactggac gaggaccccc gggtaggggc    840

tgttggtggg gacgtgcgga tccttaaccc tctggactcc tgggtcagct tcctaagcag    900

cctgcgatac tgggtagcct tcaatgtgga gcgggcttgt cagagctact tccactgtgt    960

atcctgcatc agcggtcctc taggcctata taggaataac ctcttgcagc agtttcttga   1020

ggcctggtac aaccagaagt tcctgggtac ccactgtact tttggggatg accggcacct   1080

caccaaccgc atgctcagca tgggttatgc taccaagtac acctccaggt cccgctgcta   1140

ctcagagacg ccctcgtcct tcctgcggtg gctgagccag cagacacgct ggtccaagtc   1200

gtacttccgt gagtggctgt acaacgcgct ctggtggcac cggcaccatg cgtggatgac   1260

ctacgaggcg gtggtctccg gcctgttccc cttcttcgtg gcggccactg tgctgcgtct   1320

gttctacgcg ggccgccctt gggcgctgct gtgggtgctg ctgtgcgtgc agggcgtggc   1380

actggccaag gcggccttcg cggcctggct gcggggctgc ctgcgcatgg tgcttctgtc   1440

gctctacgcg cccctctaca tgtgtggcct cctgcctgcc aagttcctgg cgctagtcac   1500

catgaaccag agtggctggg gcacctcggg ccggcggaag ctggccgcta actacgtccc   1560

tctgctgccc ctggcgctct gggcgctgct gctgcttggg ggcctggtcc gcagcgtagc   1620

acacgaggcc agggccgact ggagcggccc ttcccgcgca gccgaggcct accacttggc   1680

cgcgggggcc ggcgcctacg tgggctactg ggtggccatg ttgacgctgt actgggtggg   1740

cgtgcggagg ctttgccggc ggcggaccgg gggctaccgc gtccaggtgt gagtccagcc   1800

acgcggatgc cgcctcaagg gtcttcaggg gaggccagag gagagctgct gggccccgag   1860

ccacgaactt gctgggtggt tctctgggcc tcagtttccc tcctctgcaa aacgaggggg   1920

tcagcccaag attcttcagt ctggactata ttgggactgg gacttctggg tctccaggga   1980

gggtatttat tggtcagggt gtgggatctg aggagtggag ggaaagggtc ctgctttctc   2040

ctcgttctta tttaatctcc atttctactg tgtgatcagg atgtaataaa gaattttatt   2100

tattttc                                                             2107


<210>  41
<211>  2110
<212>  PRT
<213>  Homo sapiens

<400>  41

Ala Cys Ala Gly Ala Gly Ala Gly Gly Cys Thr Gly Gly Gly Ala Gly 
1               5                   10                  15      


Ala Gly Cys Ala Ala Gly Cys Cys Gly Gly Ala Gly Ala Gly Ala Ala 
            20                  25                  30          


Gly Ala Gly Ala Gly Ala Gly Cys Cys Cys Gly Gly Cys Cys Ala Gly 
        35                  40                  45              


Ala Cys Cys Cys Ala Cys Thr Gly Cys Gly Ala Thr Gly Ala Gly Ala 
    50                  55                  60                  


Cys Ala Gly Cys Ala Gly Gly Ala Cys Gly Cys Gly Cys Cys Cys Ala 
65                  70                  75                  80  


Ala Gly Cys Cys Cys Ala Cys Thr Cys Cys Thr Gly Cys Ala Gly Cys 
                85                  90                  95      


Cys Thr Gly Cys Cys Gly Cys Thr Gly Cys Thr Cys Cys Gly Gly Cys 
            100                 105                 110         


Cys Thr Gly Gly Cys Cys Cys Gly Gly Ala Gly Gly Gly Thr Gly Cys 
        115                 120                 125             


Thr Gly Ala Cys Cys Ala Thr Cys Gly Cys Cys Thr Thr Cys Gly Cys 
    130                 135                 140                 


Cys Cys Thr Gly Cys Thr Cys Ala Thr Cys Cys Thr Gly Gly Gly Cys 
145                 150                 155                 160 


Cys Thr Cys Ala Thr Gly Ala Cys Cys Thr Gly Gly Gly Cys Cys Thr 
                165                 170                 175     


Ala Cys Gly Cys Cys Gly Cys Cys Gly Gly Gly Gly Thr Gly Cys Cys 
            180                 185                 190         


Gly Cys Thr Gly Gly Cys Cys Thr Cys Cys Gly Ala Thr Cys Gly Cys 
        195                 200                 205             


Thr Ala Cys Gly Gly Cys Cys Thr Cys Cys Thr Gly Gly Cys Cys Thr 
    210                 215                 220                 


Thr Cys Gly Gly Cys Cys Thr Cys Thr Ala Cys Gly Gly Gly Gly Cys 
225                 230                 235                 240 


Cys Thr Thr Cys Cys Thr Thr Thr Cys Ala Gly Cys Gly Cys Ala Cys 
                245                 250                 255     


Cys Thr Gly Gly Thr Gly Gly Cys Gly Cys Ala Gly Ala Gly Cys Cys 
            260                 265                 270         


Thr Cys Thr Thr Cys Gly Cys Gly Thr Ala Cys Cys Thr Gly Gly Ala 
        275                 280                 285             


Gly Cys Ala Cys Cys Gly Gly Cys Gly Gly Gly Thr Gly Gly Cys Gly 
    290                 295                 300                 


Gly Cys Gly Gly Cys Gly Gly Cys Gly Cys Gly Gly Gly Gly Gly Cys 
305                 310                 315                 320 


Cys Gly Cys Thr Gly Gly Ala Thr Gly Cys Ala Gly Cys Cys Ala Cys 
                325                 330                 335     


Cys Gly Cys Gly Cys Gly Cys Ala Gly Thr Gly Thr Gly Gly Cys Gly 
            340                 345                 350         


Cys Thr Gly Ala Cys Cys Ala Thr Cys Thr Cys Cys Gly Cys Cys Thr 
        355                 360                 365             


Ala Cys Cys Ala Gly Gly Ala Gly Gly Ala Cys Cys Cys Cys Gly Cys 
    370                 375                 380                 


Gly Thr Ala Cys Cys Thr Gly Cys Gly Cys Cys Ala Gly Thr Gly Cys 
385                 390                 395                 400 


Cys Thr Gly Gly Cys Gly Thr Cys Cys Gly Cys Cys Cys Gly Cys Gly 
                405                 410                 415     


Cys Cys Cys Thr Gly Cys Thr Gly Thr Ala Cys Cys Cys Gly Cys Gly 
            420                 425                 430         


Cys Gly Cys Gly Cys Gly Gly Cys Thr Gly Cys Gly Cys Gly Thr Cys 
        435                 440                 445             


Cys Thr Cys Ala Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Thr Gly 
    450                 455                 460                 


Gly Cys Ala Ala Cys Cys Gly Cys Gly Cys Cys Gly Ala Gly Gly Ala 
465                 470                 475                 480 


Cys Cys Thr Cys Thr Ala Cys Ala Thr Gly Gly Thr Cys Gly Ala Cys 
                485                 490                 495     


Ala Thr Gly Thr Thr Cys Cys Gly Cys Gly Ala Gly Gly Thr Cys Thr 
            500                 505                 510         


Thr Cys Gly Cys Thr Gly Ala Cys Gly Ala Gly Gly Ala Cys Cys Cys 
        515                 520                 525             


Cys Gly Cys Cys Ala Cys Gly Thr Ala Cys Gly Thr Gly Thr Gly Gly 
    530                 535                 540                 


Gly Ala Cys Gly Gly Cys Ala Ala Cys Thr Ala Cys Cys Ala Cys Cys 
545                 550                 555                 560 


Ala Gly Cys Cys Cys Thr Gly Gly Gly Ala Ala Cys Cys Cys Gly Cys 
                565                 570                 575     


Gly Gly Cys Gly Gly Cys Gly Gly Gly Cys Gly Cys Gly Gly Thr Gly 
            580                 585                 590         


Gly Gly Cys Gly Cys Cys Gly Gly Ala Gly Cys Cys Thr Ala Thr Cys 
        595                 600                 605             


Gly Gly Gly Ala Gly Gly Thr Gly Gly Ala Gly Gly Cys Gly Gly Ala 
    610                 615                 620                 


Gly Gly Ala Thr Cys Cys Thr Gly Gly Gly Cys Gly Gly Cys Thr Gly 
625                 630                 635                 640 


Gly Cys Ala Gly Thr Gly Gly Ala Gly Gly Cys Gly Cys Thr Gly Gly 
                645                 650                 655     


Thr Gly Ala Gly Gly Ala Cys Thr Cys Gly Cys Ala Gly Gly Thr Gly 
            660                 665                 670         


Cys Gly Thr Gly Thr Gly Cys Gly Thr Gly Gly Cys Gly Cys Ala Gly 
        675                 680                 685             


Cys Gly Cys Thr Gly Gly Gly Gly Cys Gly Gly Cys Ala Ala Gly Cys 
    690                 695                 700                 


Gly Cys Gly Ala Gly Gly Thr Cys Ala Thr Gly Thr Ala Cys Ala Cys 
705                 710                 715                 720 


Ala Gly Cys Cys Thr Thr Cys Ala Ala Gly Gly Cys Gly Cys Thr Cys 
                725                 730                 735     


Gly Gly Ala Gly Ala Thr Thr Cys Gly Gly Thr Gly Gly Ala Cys Thr 
            740                 745                 750         


Ala Cys Gly Thr Gly Cys Ala Gly Gly Thr Cys Thr Gly Thr Gly Ala 
        755                 760                 765             


Cys Thr Cys Gly Gly Ala Cys Ala Cys Ala Ala Gly Gly Thr Thr Gly 
    770                 775                 780                 


Gly Ala Cys Cys Cys Cys Ala Thr Gly Gly Cys Ala Cys Thr Gly Cys 
785                 790                 795                 800 


Thr Gly Gly Ala Gly Cys Thr Cys Gly Thr Gly Cys Gly Gly Gly Thr 
                805                 810                 815     


Ala Cys Thr Gly Gly Ala Cys Gly Ala Gly Gly Ala Cys Cys Cys Cys 
            820                 825                 830         


Cys Gly Gly Gly Thr Ala Gly Gly Gly Gly Cys Thr Gly Thr Thr Gly 
        835                 840                 845             


Gly Thr Gly Gly Gly Gly Ala Cys Gly Thr Gly Cys Gly Gly Ala Thr 
    850                 855                 860                 


Cys Cys Thr Thr Ala Ala Cys Cys Cys Thr Cys Thr Gly Gly Ala Cys 
865                 870                 875                 880 


Thr Cys Cys Thr Gly Gly Gly Thr Cys Ala Gly Cys Thr Thr Cys Cys 
                885                 890                 895     


Thr Ala Ala Gly Cys Ala Gly Cys Cys Thr Gly Cys Gly Ala Thr Ala 
            900                 905                 910         


Cys Thr Gly Gly Gly Thr Ala Gly Cys Cys Thr Thr Cys Ala Ala Thr 
        915                 920                 925             


Gly Thr Gly Gly Ala Gly Cys Gly Gly Gly Cys Thr Thr Gly Thr Cys 
    930                 935                 940                 


Ala Gly Ala Gly Cys Thr Ala Cys Thr Thr Cys Cys Ala Cys Thr Gly 
945                 950                 955                 960 


Thr Gly Thr Ala Thr Cys Cys Thr Gly Cys Ala Thr Cys Ala Gly Cys 
                965                 970                 975     


Gly Gly Thr Cys Cys Thr Cys Thr Ala Gly Gly Cys Cys Thr Ala Thr 
            980                 985                 990         


Ala Thr Ala Gly Gly Ala Ala Thr  Ala Ala Cys Cys Thr  Cys Thr Thr 
        995                 1000                 1005             


Gly Cys  Ala Gly Cys Ala Gly  Thr Thr Thr Cys Thr  Thr Gly Ala 
    1010                 1015                 1020             


Gly Gly  Cys Cys Thr Gly Gly  Thr Ala Cys Ala Ala  Cys Cys Ala 
    1025                 1030                 1035             


Gly Ala  Ala Gly Thr Thr Cys  Cys Thr Gly Gly Gly  Thr Ala Cys 
    1040                 1045                 1050             


Cys Cys  Ala Cys Thr Gly Thr  Ala Cys Thr Thr Thr  Thr Gly Gly 
    1055                 1060                 1065             


Gly Gly  Ala Thr Gly Ala Cys  Cys Gly Gly Cys Ala  Cys Cys Thr 
    1070                 1075                 1080             


Cys Ala  Cys Cys Ala Ala Cys  Cys Gly Cys Ala Thr  Gly Cys Thr 
    1085                 1090                 1095             


Cys Ala  Gly Cys Ala Thr Gly  Gly Gly Thr Thr Ala  Thr Gly Cys 
    1100                 1105                 1110             


Thr Ala  Cys Cys Ala Ala Gly  Thr Ala Cys Ala Cys  Cys Thr Cys 
    1115                 1120                 1125             


Cys Ala  Gly Gly Thr Cys Cys  Cys Gly Cys Thr Gly  Cys Thr Ala 
    1130                 1135                 1140             


Cys Thr  Cys Ala Gly Ala Gly  Ala Cys Gly Cys Cys  Cys Thr Cys 
    1145                 1150                 1155             


Gly Thr  Cys Cys Thr Thr Cys  Cys Thr Gly Cys Gly  Gly Thr Gly 
    1160                 1165                 1170             


Gly Cys  Thr Gly Ala Gly Cys  Cys Ala Gly Cys Ala  Gly Ala Cys 
    1175                 1180                 1185             


Ala Cys  Gly Cys Thr Gly Gly  Thr Cys Cys Ala Ala  Gly Thr Cys 
    1190                 1195                 1200             


Gly Thr  Ala Cys Thr Thr Cys  Cys Gly Thr Gly Ala  Gly Thr Gly 
    1205                 1210                 1215             


Gly Cys  Thr Gly Thr Ala Cys  Ala Ala Cys Gly Cys  Gly Cys Thr 
    1220                 1225                 1230             


Cys Thr  Gly Gly Thr Gly Gly  Cys Ala Cys Cys Gly  Gly Cys Ala 
    1235                 1240                 1245             


Cys Cys  Ala Thr Gly Cys Gly  Thr Gly Gly Ala Thr  Gly Ala Cys 
    1250                 1255                 1260             


Cys Thr  Ala Cys Gly Ala Gly  Gly Cys Gly Gly Thr  Gly Gly Thr 
    1265                 1270                 1275             


Cys Thr  Cys Cys Gly Gly Cys  Cys Thr Gly Thr Thr  Cys Cys Cys 
    1280                 1285                 1290             


Cys Thr  Thr Cys Thr Thr Cys  Gly Thr Gly Gly Cys  Gly Gly Cys 
    1295                 1300                 1305             


Cys Ala  Cys Thr Gly Thr Gly  Cys Thr Gly Cys Gly  Thr Cys Thr 
    1310                 1315                 1320             


Gly Thr  Thr Cys Thr Ala Cys  Gly Cys Gly Gly Gly  Cys Cys Gly 
    1325                 1330                 1335             


Cys Cys  Cys Thr Thr Gly Gly  Gly Cys Gly Cys Thr  Gly Cys Thr 
    1340                 1345                 1350             


Gly Thr  Gly Gly Gly Thr Gly  Cys Thr Gly Cys Thr  Gly Thr Gly 
    1355                 1360                 1365             


Cys Gly  Thr Gly Cys Ala Gly  Gly Gly Cys Gly Thr  Gly Gly Cys 
    1370                 1375                 1380             


Ala Cys  Thr Gly Gly Cys Cys  Ala Ala Gly Gly Cys  Gly Gly Cys 
    1385                 1390                 1395             


Cys Thr  Thr Cys Gly Cys Gly  Gly Cys Cys Thr Gly  Gly Cys Thr 
    1400                 1405                 1410             


Gly Cys  Gly Gly Gly Gly Cys  Thr Gly Cys Cys Thr  Gly Cys Gly 
    1415                 1420                 1425             


Cys Ala  Thr Gly Gly Thr Gly  Cys Thr Thr Cys Thr  Gly Thr Cys 
    1430                 1435                 1440             


Gly Cys  Thr Cys Thr Ala Cys  Gly Cys Gly Cys Cys  Cys Cys Thr 
    1445                 1450                 1455             


Cys Thr  Ala Cys Ala Thr Gly  Thr Gly Thr Gly Gly  Cys Cys Thr 
    1460                 1465                 1470             


Cys Cys  Thr Gly Cys Cys Thr  Gly Cys Cys Ala Ala  Gly Thr Thr 
    1475                 1480                 1485             


Cys Cys  Thr Gly Gly Cys Gly  Cys Thr Ala Gly Thr  Cys Ala Cys 
    1490                 1495                 1500             


Cys Ala  Thr Gly Ala Ala Cys  Cys Ala Gly Ala Gly  Thr Gly Gly 
    1505                 1510                 1515             


Cys Thr  Gly Gly Gly Gly Cys  Ala Cys Cys Thr Cys  Gly Gly Gly 
    1520                 1525                 1530             


Cys Cys  Gly Gly Cys Gly Gly  Ala Ala Gly Cys Thr  Gly Gly Cys 
    1535                 1540                 1545             


Cys Gly  Cys Thr Ala Ala Cys  Thr Ala Cys Gly Thr  Cys Cys Cys 
    1550                 1555                 1560             


Thr Cys  Thr Gly Cys Thr Gly  Cys Cys Cys Cys Thr  Gly Gly Cys 
    1565                 1570                 1575             


Gly Cys  Thr Cys Thr Gly Gly  Gly Cys Gly Cys Thr  Gly Cys Thr 
    1580                 1585                 1590             


Gly Cys  Thr Gly Cys Thr Thr  Gly Gly Gly Gly Gly  Cys Cys Thr 
    1595                 1600                 1605             


Gly Gly  Thr Cys Cys Gly Cys  Ala Gly Cys Gly Thr  Ala Gly Cys 
    1610                 1615                 1620             


Ala Cys  Ala Cys Gly Ala Gly  Gly Cys Cys Ala Gly  Gly Gly Cys 
    1625                 1630                 1635             


Cys Gly  Ala Cys Thr Gly Gly  Ala Gly Cys Gly Gly  Cys Cys Cys 
    1640                 1645                 1650             


Thr Thr  Cys Cys Cys Gly Cys  Gly Cys Ala Gly Cys  Cys Gly Ala 
    1655                 1660                 1665             


Gly Gly  Cys Cys Thr Ala Cys  Cys Ala Cys Thr Thr  Gly Gly Cys 
    1670                 1675                 1680             


Cys Gly  Cys Gly Gly Gly Gly  Gly Cys Cys Gly Gly  Cys Gly Cys 
    1685                 1690                 1695             


Cys Thr  Ala Cys Gly Thr Gly  Gly Gly Cys Thr Ala  Cys Thr Gly 
    1700                 1705                 1710             


Gly Gly  Thr Gly Gly Cys Cys  Ala Thr Gly Thr Thr  Gly Ala Cys 
    1715                 1720                 1725             


Gly Cys  Thr Gly Thr Ala Cys  Thr Gly Gly Gly Thr  Gly Gly Gly 
    1730                 1735                 1740             


Cys Gly  Thr Gly Cys Gly Gly  Ala Gly Gly Cys Thr  Thr Thr Gly 
    1745                 1750                 1755             


Cys Cys  Gly Gly Cys Gly Gly  Cys Gly Gly Ala Cys  Cys Gly Gly 
    1760                 1765                 1770             


Gly Gly  Gly Cys Thr Ala Cys  Cys Gly Cys Gly Thr  Cys Cys Ala 
    1775                 1780                 1785             


Gly Gly  Thr Gly Thr Gly Ala  Gly Thr Cys Cys Ala  Gly Cys Cys 
    1790                 1795                 1800             


Ala Cys  Gly Cys Gly Gly Ala  Thr Gly Cys Cys Gly  Cys Cys Thr 
    1805                 1810                 1815             


Cys Ala  Ala Gly Gly Gly Thr  Cys Thr Thr Cys Ala  Gly Gly Gly 
    1820                 1825                 1830             


Gly Ala  Gly Gly Cys Cys Ala  Gly Ala Gly Gly Ala  Gly Ala Gly 
    1835                 1840                 1845             


Cys Thr  Gly Cys Thr Gly Gly  Gly Cys Cys Cys Cys  Gly Ala Gly 
    1850                 1855                 1860             


Cys Cys  Ala Cys Gly Ala Ala  Cys Thr Thr Gly Cys  Thr Gly Gly 
    1865                 1870                 1875             


Gly Thr  Gly Gly Thr Thr Cys  Thr Cys Thr Gly Gly  Gly Cys Cys 
    1880                 1885                 1890             


Thr Cys  Ala Gly Thr Thr Thr  Cys Cys Cys Thr Cys  Cys Thr Cys 
    1895                 1900                 1905             


Thr Gly  Cys Ala Ala Ala Ala  Cys Gly Ala Gly Gly  Gly Gly Gly 
    1910                 1915                 1920             


Thr Cys  Ala Gly Cys Cys Cys  Ala Ala Gly Ala Thr  Thr Cys Thr 
    1925                 1930                 1935             


Thr Cys  Ala Gly Thr Cys Thr  Gly Gly Ala Cys Thr  Ala Thr Ala 
    1940                 1945                 1950             


Thr Thr  Gly Gly Gly Ala Cys  Thr Gly Gly Gly Ala  Cys Thr Thr 
    1955                 1960                 1965             


Cys Thr  Gly Gly Gly Thr Cys  Thr Cys Cys Ala Gly  Gly Gly Ala 
    1970                 1975                 1980             


Gly Gly  Gly Thr Ala Thr Thr  Thr Ala Thr Thr Gly  Gly Thr Cys 
    1985                 1990                 1995             


Ala Gly  Gly Gly Thr Gly Thr  Gly Gly Gly Ala Thr  Cys Thr Gly 
    2000                 2005                 2010             


Ala Gly  Gly Ala Gly Thr Gly  Gly Ala Gly Gly Gly  Ala Ala Ala 
    2015                 2020                 2025             


Gly Gly  Gly Thr Cys Cys Thr  Gly Cys Thr Thr Thr  Cys Thr Cys 
    2030                 2035                 2040             


Cys Thr  Cys Gly Thr Thr Cys  Thr Thr Ala Thr Thr  Thr Ala Ala 
    2045                 2050                 2055             


Thr Cys  Thr Cys Cys Ala Thr  Thr Thr Cys Thr Ala  Cys Thr Gly 
    2060                 2065                 2070             


Thr Gly  Thr Gly Ala Thr Cys  Ala Gly Gly Ala Thr  Gly Thr Ala 
    2075                 2080                 2085             


Ala Thr  Ala Ala Ala Gly Ala  Ala Thr Thr Thr Thr  Ala Thr Thr 
    2090                 2095                 2100             


Thr Ala  Thr Thr Thr Thr Cys  
    2105                 2110 


<210>  42
<211>  4240
<212>  DNA
<213>  Homo sapiens

<400>  42
agaccccctt aagttggagg aggcagaagg gcaacaacgg cggggaagga gaagtcaaga     60

cgtctggaaa gaattaccca gtcctggctt cgagcagccc attgaaccag agacttgaaa    120

cagccccagc caaagacttt tctcccaatt ctgcgcttcc tgggttctgc tgagtcttcc    180

acaggctttt tttttttttt tttttttttt taagacgaaa aagagatttt ctgttatcgg    240

gggcagaaag actgaagccc aaaaaaaaaa aaaaaaaaaa aagaaaagaa aagaaaaaag    300

aaaagttaat ttatttttaa agcataattt ttttaagaat tagactgaag tgcaacggaa    360

acataaagag aatattagtg aaattatttt ttaaagtggg gaagaatcaa acatttaaga    420

ctcccctatc ctttttaaat gttgttttta aatttcttat tttttttggc cggtcgtctc    480

aaattcatct gatctcttat tacctcaatt ttggaaactg cccgccaccg accctccggg    540

accacacaga caggctgagg acgactttat gaccaagagc tgaacaagat gcattgtgag    600

aggtttctat gtatcctgag aataattgga accacactct ttggagtctc tctcctcctt    660

ggaatcacag ctgcttatat tgttggctac cagtttatcc aaacggataa ttactatttc    720

tcttttggac tgtatggtgc ctttttggca tcacacctca tcatccaaag cctgtttgcc    780

tttttggagc accgaaaaat gaaaaaatcc ctagaaaccc ccataaagtt gaacaaaaca    840

gttgcccttt gcatcgctgc ctatcaagaa gatccagact acttaaggaa atgtttgcaa    900

tctgtgaaaa ggctaaccta ccctgggatt aaagttgtca tggtcataga tgggaactca    960

gaagatgacc tttacatgat ggacatcttc agtgaagtca tgggcagaga caaatcagcc   1020

acttatatct ggaagaacaa cttccacgaa aagggtcccg gtgagacaga tgagtcacat   1080

aaagaaagct cgcaacacgt aacgcaattg gtcttgtcca acaaaagtat ctgcatcatg   1140

caaaaatggg gtggaaaaag agaagtcatg tacacagcct tcagagcact gggacgaagt   1200

gtggattatg tacaggtttg tgattcagac actatgcttg acccagcctc atctgtggag   1260

atggtaaaag ttttagaaga agatcccatg gttggaggtg ttgggggaga tgtccagatt   1320

ttaaacaagt acgattcctg gatctcattc ctcagcagtg taagatattg gatggctttt   1380

aatatagaaa gggcctgtca gtcttatttt gggtgtgttc agtgcattag tggacctctg   1440

ggaatgtaca gaaactcctt gttgcatgag tttgtggaag attggtacaa tcaagaattt   1500

atgggcaacc aatgtagctt tggtgatgac aggcatctca cgaaccgggt gctgagcctg   1560

ggctatgcaa caaaatacac agctcgatct aagtgcctta ctgaaacacc tatagaatat   1620

ctcagatggc taaaccagca gacccgttgg agcaagtcct acttccgaga atggctgtac   1680

aatgcaatgt ggtttcacaa acatcacttg tggatgacct acgaagcgat tatcactgga   1740

ttctttcctt tctttctcat tgccacagta atccagctct tctaccgggg taaaatttgg   1800

aacattctcc tcttcttgtt aactgtccag ctagtaggtc tcataaaatc atcttttgcc   1860

agctgcctta gaggaaatat cgtcatggtc ttcatgtctc tctactcagt gttatacatg   1920

tcgagtttac ttcccgccaa gatgtttgca attgcaacaa taaacaaagc tgggtggggc   1980

acatcaggaa ggaaaaccat tgttgttaat ttcataggac tcattccagt atcagtttgg   2040

tttacaatcc tcctgggtgg tgtgattttc accatttata aggagtctaa aaggccattt   2100

tcagaatcca aacagacagt tctaattgtt ggaacgttgc tctatgcatg ctattgggtc   2160

atgcttttga cgctgtatgt agttctcatc aataagtgtg gcaggcggaa gaagggacaa   2220

caatatgaca tggtgcttga tgtatgatct tccatgtttt gacgtttgca gtcacacaca   2280

acaccttagt tcctctaggg gctgtacagt attgtggcat cagataatgc caccaaagga   2340

gacatatcac tgctgctggg acttgaacaa agacatttat atgggtttat tttcattctg   2400

ccaaagtaaa acaatacatc aacaagaaga aactcagatt taacctgtta tttctatgaa   2460

aatgggatga attctttgtt tatgcacttt ttccttactg tgcatccgcc tgaaagtgtt   2520

ttgccctata tacctcacta gccatgcttt atgtgggtta tcatggaaga aaaggatttt   2580

ggaaactcaa ggaaaagttc tttcaaccta tacaacctaa cttatggact gttttgatag   2640

atgataattt ttttttttta ggaaggattt tctttttaac tttaccaaat gaaatgccaa   2700

aggaagtttt aaaggccgtt ggctgtgctg tattttgata taattgtact gtgtttttaa   2760

attttgtatg ccaatcttaa agacaaattt tgcatattct ctattttact tttctgccaa   2820

aataaacctg ttcttccttt tttaaaataa aataagttct taaaaaattt atacttaaaa   2880

aatcctgccc aaaatgtgaa gcttggttga ctgatgttca tgatagaaag aataaaatgt   2940

ttctctctct ctacctttta aaattgaata gtttatttct gtgaaagaag tatttaaact   3000

ttcaatattt taactttttg tttttatttc ttttagaaaa ggccaatata cctatcacac   3060

tttggaagta aaaatacaca ctttcgtgtg tacctaaaaa aaaaatcgtt gaaaatcaag   3120

gccaaaggta gtgcaatttt ttcattaaga tttaaaaaaa agggaatgat agtctttgaa   3180

agaaaacagt aggcatccag cactggacaa aacatgggta tcaaagatga ataatctttg   3240

gagattctgg cagtgttttc ccagaacaag tcaagtggaa agtggagaaa ttatctgtat   3300

aattttggac acatacaatg cagtttatca aaggttttgt tctgtggcct gaatttactg   3360

ggtcctacct acacattgaa catgttttgc ctgtcttttt tttttttttc aacttgccag   3420

ttcactttac atgttagtat aatgtttaca cgggtgagtt ggataaatta taaaacatat   3480

aaattcaaaa ttggcagata gaatcaccaa gtatctatcc tcttttactt tcaaatgagg   3540

aattttgttt ttctgaatta cacagatcat cacttcctat ttcctgttct ggacctgtat   3600

aaaaatgtct acacagtaga agtgacatca aggtttaata agtatatcaa tgattggcac   3660

atataaaaat tgttgaacca catactctga acttggctaa tttagttact gcaaggcctc   3720

cattatccag ttttattttt tacacgattg accttgcctt gtagctggtg ctgtgtagac   3780

ctgtgttgaa aacacaatcg gaatatatga ataattgaat aaacagcatt atggtgaggc   3840

agagacacat ggagaagtgt taaaaaaaaa atgggcttcc tgcctttctg cctctttttt   3900

atgcagtcat ctatgttaca tctatcctgc ctaagaaaaa gctgcacatc ctaccttcag   3960

agtacaaaaa ggtacatctg agactcaaga ctctcactga ttggagagct tgtggaaaac   4020

aaaacacacc atgccaataa atgagatgaa aacttgagtt tgccttttta actatttatg   4080

ttctaagtta agctttgata acattcaaat gtcaaattct ctcattctta taaaaagttg   4140

aattaattgc ctgtatttat tttagcaatt attcaatgta tttccagtat aggatgtata   4200

gtataattaa ttttttgtaa ataaaatatt tttgataaga                         4240


<210>  43
<211>  4191
<212>  DNA
<213>  Homo sapiens

<400>  43
aattctcttc agcgcctctt tcctgccagc aggaaggttt tgctgccttg gctttcggga     60

gccccctaga cagcgaactg ccccttcgcg tgcagaagtc ggggaagagt gctctcagct    120

cgccttcctt gcaggatgcc ggtgcagctg acgacagccc tgcgtgtggt gggcaccagc    180

ctgtttgccc tggcagtgct gggtggcatc ctggcagcct atgtgacggg ctaccagttc    240

atccacacgg aaaagcacta cctgtccttc ggcctgtacg gcgccatcct gggcctgcac    300

ctgctcattc agagcctttt tgccttcctg gagcaccggc gcatgcgacg tgccggccag    360

gccctgaagc tgccctcccc gcggcggggc tcggtggcac tgtgcattgc cgcataccag    420

gaggaccctg actacttgcg caagtgcctg cgctcggccc agcgcatctc cttccctgac    480

ctcaaggtgg tcatggtggt ggatggcaac cgccaggagg acgcctacat gctggacatc    540

ttccacgagg tgctgggcgg caccgagcag gccggcttct ttgtgtggcg cagcaacttc    600

catgaggcag gcgagggtga gacggaggcc agcctgcagg agggcatgga ccgtgtgcgg    660

gatgtggtgc gggccagcac cttctcgtgc atcatgcaga agtggggagg caagcgcgag    720

gtcatgtaca cggccttcaa ggccctcggc gattcggtgg actacatcca ggtgtgcgac    780

tctgacactg tgctggatcc agcctgcacc atcgagatgc ttcgagtcct ggaggaggat    840

ccccaagtag ggggagtcgg gggagatgtc cagatcctca acaagtacga ctcatggatt    900

tccttcctga gcagcgtgcg gtactggatg gccttcaacg tggagcgggc ctgccagtcc    960

tactttggct gtgtgcagtg tattagtggg cccttgggca tgtaccgcaa cagcctcctc   1020

cagcagttcc tggaggactg gtaccatcag aagttcctag gcagcaagtg cagcttcggg   1080

gatgaccggc acctcaccaa ccgagtcctg agccttggct accgaactaa gtataccgcg   1140

cgctccaagt gcctcacaga gacccccact aagtacctcc ggtggctcaa ccagcaaacc   1200

cgctggagca agtcttactt ccgggagtgg ctctacaact ctctgtggtt ccataagcac   1260

cacctctgga tgacctacga gtcagtggtc acgggtttct tccccttctt cctcattgcc   1320

acggttatac agcttttcta ccggggccgc atctggaaca ttctcctctt cctgctgacg   1380

gtgcagctgg tgggcattat caaggccacc tacgcctgct tccttcgggg caatgcagag   1440

atgatcttca tgtccctcta ctccctcctc tatatgtcca gccttctgcc ggccaagatc   1500

tttgccattg ctaccatcaa caaatctggc tggggcacct ctggccgaaa aaccattgtg   1560

gtgaacttca ttggcctcat tcctgtgtcc atctgggtgg cagttctcct gggagggctg   1620

gcctacacag cttattgcca ggacctgttc agtgagacag agctagcctt ccttgtctct   1680

ggggctatac tgtatggctg ctactgggtg gccctcctca tgctatatct ggccatcatc   1740

gcccggcgat gtgggaagaa gccggagcag tacagcttgg cttttgctga ggtgtgacat   1800

ggcccccaag cagagcgggt aaagtgcaat gggtaaggga gggaagggga atggaagaga   1860

aaagacaggg tgggagggag gagggagtgc tgtgttttag tctcttaatg gtccaaagga   1920

caaatctaaa atgcaaagaa cggtgatgta gtatggcctg acagctctgt ttagaggagg   1980

caacactgat cccccagatg cagggctgca ggggattctg tgttttcaga ctgcctgtct   2040

gcttgcatct gcacataggc agtagcctcc tcctgggctc cagagggcac tcagaagttg   2100

tgctaaacca agttaagtcc cattcagtgg caacttgtga taggtacctg agtgacggca   2160

acctgcggaa ggaggttctc ccagcccatc tgaacacaac cagaggtggc aggagaattt   2220

ctactgagcg agctgggccg gttagtgtat gtcaccccca ccccacccct aagtagtcat   2280

caatgcaata agattgcgcc tgagatacaa ggcccagaag cctgatcttt gggcatcaga   2340

aaacagggtc caggaatggt gctttatgtg agatacccca ctccacatca acattccagg   2400

gatgagccaa accagcaggg agttagcact gaactgcttt taaaagtgca cattaaaaag   2460

gaaagtttgc caggaggaac aaagagattg tggtggtgct aaaggaggcc ataagctaca   2520

cagaggcctt gggtgttcca cctggaaact gctcagacgt ctagatgggt tcttagcttg   2580

tctgtgatct ctgctgggga gataaaaaga ttaagcccca acatgttcag aaaagaagtg   2640

aagtcttggg tattttaacc tgtatactct tgaattcctc tcaaattcag ctctgatctg   2700

aggctaagac acactcccca cttcactttc ttcaaagcca cattttttga ggtatcactg   2760

cagtcacctc ttctaccctc atcatcatag gtaaggtttt caaggtggca attggggcgg   2820

agccccggct cttatagaag cttcagcagg aggcaagcgt gttctcagca catatgggaa   2880

ctatgaggag cctctgatca aattggctac aatcttggag ctgcttggac ggattccttg   2940

gcagccgggt tagcatgtgt gactttcagg ctactgttct tgacaatcat ctccaatgga   3000

aagcttttca gtgttcccaa agtgaactct caaatccaaa atggttatct ttgagaccat   3060

ccattctcct cagtggcttc tccagggaat tcttacagcc aagttgtgac agtcactgca   3120

tttgcctgct tctttccaga aaccaaacta ggagatgaaa ctggttccta catcctaagg   3180

ttcttgcttt ctctctcatg cctcctgagg ctgtttttgg ctgttttccc tctgctgctt   3240

ttggggaatg aggggaagcc attttccagt gacttgcaat ccaggctgtt ctcagcgttt   3300

tgagtttaaa acctgggatc ctgactaagc ctttgactta agggttgctt gcttgccctc   3360

caaatgtcct ttctcagagg ggccagctaa cccgtgcaga accagcacta aggtggacag   3420

cagacaagag ggcaagcctc tagtgtacca agtgcttcct acaaagacgc aaggtgtgct   3480

ctgagccaca gatgggcaaa ccctggtgct ttccttcatc tcccacgaac tcaagggttt   3540

tccaggtgta gctaacagtt gccacatcac acagacctcg agtttctggt aagactgctg   3600

gttgacatca gacccaaccc atgaaggctg gaaggcagca ggcatttgct aaggcagctg   3660

atccaggcaa tcgttctgct ggccaagaag ttaaactatt ttgagcatta gaatggagga   3720

aatccggtca gccaagtgca gagttcagac ttcgctaagg gcttgttttt cttcagcatt   3780

tacttgaaga ttaatgtagg atgacaggct ctcctggctg tcctaccatc agctctgcct   3840

tgcactgtgg tcgtcaactt tcctcaaatc aaaaacaggc aggtacaggt agtgggctca   3900

caacgtttga cctcgactgg tttttctaag ttattttgta catttttcag cagcaaaacc   3960

aaactgggtc ttcagcttta tccccgtttc ttgcaaggga agagccttta tacaattgga   4020

cgcattttgg tttttcctca ttgagaattc aaatcctctt ttgtattgtt tctacaataa   4080

tttgtaaaca tatttatttt tacctgcttt tttttttttt tttaattttc aggtcaagtt   4140

ttttatactg cacttatttg tcaaaataaa gattctcaca tatgccggtt a            4191


<210>  44
<211>  4212
<212>  DNA
<213>  Homo sapiens

<400>  44
gagtgcgttc gcggctgctt tgacctggtg ggcgccgcct ccggcactgc accgaggcgg     60

ggcgccagcg cccaggttgc tgggctggcc ttggcgcccc cttcccctac ccagagcgca    120

ggcaggcagg ggggtcccgc cgcgcccctt cagcatatgc cggtgcagct gacgacagcc    180

ctgcgtgtgg tgggcaccag cctgtttgcc ctggcagtgc tgggtggcat cctggcagcc    240

tatgtgacgg gctaccagtt catccacacg gaaaagcact acctgtcctt cggcctgtac    300

ggcgccatcc tgggcctgca cctgctcatt cagagccttt ttgccttcct ggagcaccgg    360

cgcatgcgac gtgccggcca ggccctgaag ctgccctccc cgcggcgggg ctcggtggca    420

ctgtgcattg ccgcatacca ggaggaccct gactacttgc gcaagtgcct gcgctcggcc    480

cagcgcatct ccttccctga cctcaaggtg gtcatggtgg tggatggcaa ccgccaggag    540

gacgcctaca tgctggacat cttccacgag gtgctgggcg gcaccgagca ggccggcttc    600

tttgtgtggc gcagcaactt ccatgaggca ggcgagggtg agacggaggc cagcctgcag    660

gagggcatgg accgtgtgcg ggatgtggtg cgggccagca ccttctcgtg catcatgcag    720

aagtggggag gcaagcgcga ggtcatgtac acggccttca aggccctcgg cgattcggtg    780

gactacatcc aggtgtgcga ctctgacact gtgctggatc cagcctgcac catcgagatg    840

cttcgagtcc tggaggagga tccccaagta gggggagtcg ggggagatgt ccagatcctc    900

aacaagtacg actcatggat ttccttcctg agcagcgtgc ggtactggat ggccttcaac    960

gtggagcggg cctgccagtc ctactttggc tgtgtgcagt gtattagtgg gcccttgggc   1020

atgtaccgca acagcctcct ccagcagttc ctggaggact ggtaccatca gaagttccta   1080

ggcagcaagt gcagcttcgg ggatgaccgg cacctcacca accgagtcct gagccttggc   1140

taccgaacta agtataccgc gcgctccaag tgcctcacag agacccccac taagtacctc   1200

cggtggctca accagcaaac ccgctggagc aagtcttact tccgggagtg gctctacaac   1260

tctctgtggt tccataagca ccacctctgg atgacctacg agtcagtggt cacgggtttc   1320

ttccccttct tcctcattgc cacggttata cagcttttct accggggccg catctggaac   1380

attctcctct tcctgctgac ggtgcagctg gtgggcatta tcaaggccac ctacgcctgc   1440

ttccttcggg gcaatgcaga gatgatcttc atgtccctct actccctcct ctatatgtcc   1500

agccttctgc cggccaagat ctttgccatt gctaccatca acaaatctgg ctggggcacc   1560

tctggccgaa aaaccattgt ggtgaacttc attggcctca ttcctgtgtc catctgggtg   1620

gcagttctcc tgggagggct ggcctacaca gcttattgcc aggacctgtt cagtgagaca   1680

gagctagcct tccttgtctc tggggctata ctgtatggct gctactgggt ggccctcctc   1740

atgctatatc tggccatcat cgcccggcga tgtgggaaga agccggagca gtacagcttg   1800

gcttttgctg aggtgtgaca tggcccccaa gcagagcggg taaagtgcaa tgggtaaggg   1860

agggaagggg aatggaagag aaaagacagg gtgggaggga ggagggagtg ctgtgtttta   1920

gtctcttaat ggtccaaagg acaaatctaa aatgcaaaga acggtgatgt agtatggcct   1980

gacagctctg tttagaggag gcaacactga tcccccagat gcagggctgc aggggattct   2040

gtgttttcag actgcctgtc tgcttgcatc tgcacatagg cagtagcctc ctcctgggct   2100

ccagagggca ctcagaagtt gtgctaaacc aagttaagtc ccattcagtg gcaacttgtg   2160

ataggtacct gagtgacggc aacctgcgga aggaggttct cccagcccat ctgaacacaa   2220

ccagaggtgg caggagaatt tctactgagc gagctgggcc ggttagtgta tgtcaccccc   2280

accccacccc taagtagtca tcaatgcaat aagattgcgc ctgagataca aggcccagaa   2340

gcctgatctt tgggcatcag aaaacagggt ccaggaatgg tgctttatgt gagatacccc   2400

actccacatc aacattccag ggatgagcca aaccagcagg gagttagcac tgaactgctt   2460

ttaaaagtgc acattaaaaa ggaaagtttg ccaggaggaa caaagagatt gtggtggtgc   2520

taaaggaggc cataagctac acagaggcct tgggtgttcc acctggaaac tgctcagacg   2580

tctagatggg ttcttagctt gtctgtgatc tctgctgggg agataaaaag attaagcccc   2640

aacatgttca gaaaagaagt gaagtcttgg gtattttaac ctgtatactc ttgaattcct   2700

ctcaaattca gctctgatct gaggctaaga cacactcccc acttcacttt cttcaaagcc   2760

acattttttg aggtatcact gcagtcacct cttctaccct catcatcata ggtaaggttt   2820

tcaaggtggc aattggggcg gagccccggc tcttatagaa gcttcagcag gaggcaagcg   2880

tgttctcagc acatatggga actatgagga gcctctgatc aaattggcta caatcttgga   2940

gctgcttgga cggattcctt ggcagccggg ttagcatgtg tgactttcag gctactgttc   3000

ttgacaatca tctccaatgg aaagcttttc agtgttccca aagtgaactc tcaaatccaa   3060

aatggttatc tttgagacca tccattctcc tcagtggctt ctccagggaa ttcttacagc   3120

caagttgtga cagtcactgc atttgcctgc ttctttccag aaaccaaact aggagatgaa   3180

actggttcct acatcctaag gttcttgctt tctctctcat gcctcctgag gctgtttttg   3240

gctgttttcc ctctgctgct tttggggaat gaggggaagc cattttccag tgacttgcaa   3300

tccaggctgt tctcagcgtt ttgagtttaa aacctgggat cctgactaag cctttgactt   3360

aagggttgct tgcttgccct ccaaatgtcc tttctcagag gggccagcta acccgtgcag   3420

aaccagcact aaggtggaca gcagacaaga gggcaagcct ctagtgtacc aagtgcttcc   3480

tacaaagacg caaggtgtgc tctgagccac agatgggcaa accctggtgc tttccttcat   3540

ctcccacgaa ctcaagggtt ttccaggtgt agctaacagt tgccacatca cacagacctc   3600

gagtttctgg taagactgct ggttgacatc agacccaacc catgaaggct ggaaggcagc   3660

aggcatttgc taaggcagct gatccaggca atcgttctgc tggccaagaa gttaaactat   3720

tttgagcatt agaatggagg aaatccggtc agccaagtgc agagttcaga cttcgctaag   3780

ggcttgtttt tcttcagcat ttacttgaag attaatgtag gatgacaggc tctcctggct   3840

gtcctaccat cagctctgcc ttgcactgtg gtcgtcaact ttcctcaaat caaaaacagg   3900

caggtacagg tagtgggctc acaacgtttg acctcgactg gtttttctaa gttattttgt   3960

acatttttca gcagcaaaac caaactgggt cttcagcttt atccccgttt cttgcaaggg   4020

aagagccttt atacaattgg acgcattttg gtttttcctc attgagaatt caaatcctct   4080

tttgtattgt ttctacaata atttgtaaac atatttattt ttacctgctt tttttttttt   4140

ttttaatttt caggtcaagt tttttatact gcacttattt gtcaaaataa agattctcac   4200

atatgccggt ta                                                       4212


<210>  45
<211>  1198
<212>  DNA
<213>  Homo sapiens

<400>  45
agtcggagcg cgcggcggcg cggagcggag cgggaggagg ggcatggagc cgccgcgggc     60

ctgctgagct ccggagcgcg gcagccggcg gcacgatgcc ggtgcagctg acgacagccc    120

tgcgtgtggt gggcaccagc ctgtttgccc tggcagtgct gggtggcatc ctggcagcct    180

atgtgacggg ctaccagttc atccacacgg aaaagcacta cctgtccttc ggcctgtacg    240

gcgccatcct gggcctgcac ctgctcattc agagcctttt tgccttcctg gagcaccggc    300

gcatgcgacg tgccggccag gccctgaagc tgccctcccc gcggcggggc tcggtggcac    360

tgtgcattgc cgcataccag gaggaccctg actacttgcg caagtgcctg cgctcggccc    420

agcgcatctc cttccctgac ctcaaggtgg tcatggtggt ggatggcaac cgccaggagg    480

acgcctacat gctggacatc ttccacgagg tgctgggcgg caccgagcag gccggcttct    540

ttgtgtggcg cagcaacttc catgaggcag gcgagggtga gacggaggcc agcctgcagg    600

agggcatgga ccgtgtgcgg gatgtggtgc gggccagcac cttctcgtgc atcatgcaga    660

agtggggagg caagcgcgag gtcatgtaca cggccttcaa ggccctcggc gattcggtgg    720

actacatcca ggtgtgcgac tctgacactg tgctggatcc agcctgcacc atcgagatgc    780

ttcgagtcct ggaggaggat ccccaagtag ggggagtcgg gggagatgtc cagcccccag    840

ggaaaggtat ggcagtagag gatgaccagg tccaagctgc ccaggtcaga gctacggaag    900

catggtccgt tcaccaacgc cacgtttcta gagagcagtg agctgattct ccaatggtga    960

gcaggggact acatgtgaac tgggacctgc aggccaatgt atccctgagg aaaagtccac   1020

aagaacaatt caagaaacta gtaagaaaca atgggcagaa agctgtggga cgaaagcaca   1080

gcaggcttct gggaggctgg agatcctttc tctcaagggc aggattattc ccacctgcca   1140

cagttcacat gccacaaata acatctcacc ttcagtcaag aaaaacgcaa aggaaaaa     1198


