                               SEQUENCE LISTING

<110> NEW YORK UNIVERSITY
 
<120> METHODS AND COMPOSITIONS FOR MEASURING AND INHIBITING EXONUCLEASE
      ACTIVITY

<130> 243735.000233

<140>
<141>

<150> 63/236,037
<151> 2021-08-23

<150> 63/130,174
<151> 2020-12-23

<160> 27    

<170> PatentIn version 3.5

<210> 1
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
uugccgaauu aagcgca                                                      17


<210> 2
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
uaagcgcuua auucggc                                                      17


<210> 3
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
uugccgaauu aagcgcca                                                     18


<210> 4
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
uaaggcgcuu aauucggcaa                                                   20


<210> 5
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
uuuuuucggc cca                                                          13


<210> 6
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
aaauagggcc gaaaaaa                                                      17


<210> 7
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
ucuuuucggc cca                                                          13


<210> 8
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
aaauagggcc gaaaaga                                                      17


<210> 9
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
ucuuuucggc cca                                                          13


<210> 10
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
aaauagggcc gaaaaga                                                      17


<210> 11
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
ucuuuucggc cca                                                          13


<210> 12
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
ucuuuucggc cca                                                          13


<210> 13
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
ucuuuucggc cca                                                          13


<210> 14
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
aaauagggcc gaaaaga                                                      17


<210> 15
<211> 1629
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
atggccgaaa atgtcacggg tctgttcaaa gattgttcca aagttatcac gggtctgcat       60

ccgacgcaag caccgacgca cctgtctgtc gataccaaat ttaaaacgga aggcctgtgc      120

gtggatattc cgggtatccc gaaagacatg acgtatcgtc gcctgattag catgatgggc      180

ttcaaaatga actatcaagt gaatggttac ccgaacatgt ttattacccg tgaagaagcc      240

atccgtcatg tgcgcgcatg gatcggcttc gatgttgaag gttgtcacgc aacgcgcgaa      300

gctgttggca ccaatctgcc gctgcagctg ggctttagca cgggtgtgaa cctggttgcg      360

gtgccgaccg gttatgttga taccccgaac aatacggact tcagtcgcgt gtccgcaaaa      420

ccgccgccgg gtgatcagtt taaacatctg attccgctga tgtacaaagg tctgccgtgg      480

aatgtggttc gtattaaaat cgttcaaatg ctgtcagata ccctgaaaaa cctgtcggac      540

cgcgtcgtgt tcgttctgtg ggcacacggc tttgaactga cgtctatgaa atatttcgtc      600

aaaatcggtc cggaacgcac ctgctgtctg tgcgatcgtc gcgcgacctg tttttcaacg      660

gcgtcggaca cctacgcctg ctggcatcac agtattggct tcgattatgt ctacaatccg      720

tttatgatcg acgtgcagca atggggcttc accggtaatc tgcagtcgaa ccatgatctg      780

tattgccaag tccatggtaa cgcgcacgtg gccagctgtg acgccattat gacgcgttgc      840

ctggcagtgc acgaatgttt tgttaaacgc gtcgattgga ccattgaata tccgattatc      900

ggcgacgaac tgaaaatcaa tgcggcctgt cgtaaagtgc agcacatggt tgtcaaagca      960

gctctgctgg ccgataaatt tccggttctg cacgacattg gtaacccgaa agctatcaaa     1020

tgcgtgccgc aggcggatgt tgaatggaaa ttctatgatg cccaaccgtg ttctgacaaa     1080

gcatacaaaa tcgaagaact gttttatagt tacgctacgc attccgataa attcaccgac     1140

ggcgtttgcc tgttttggaa ctgtaatgtc gatcgctatc cggccaatag tatcgtttgc     1200

cgttttgaca cccgcgtcct gtccaacctg aatctgccgg gttgtgatgg cggttcactg     1260

tacgtcaata aacatgcatt tcacaccccg gctttcgaca aatccgcgtt tgttaacctg     1320

aaacagctgc cgtttttcta ttacagcgat tctccgtgcg aaagccatgg caaacaagtg     1380

gtttctgata ttgactatgt gccgctgaaa agtgcgacct gcatcacgcg ttgtaacctg     1440

ggcggtgctg tttgtcgtca tcacgcgaat gaatatcgcc tgtacctgga tgcttacaac     1500

atgatgatta gcgcgggttt ctctctgtgg gtgtataaac agtttgatac ctacaacctg     1560

tggaatacgt ttacccgtct gcaaggcggc ggttctggcg gcggctccca ccaccaccat     1620

caccattaa                                                             1629


<210> 16
<211> 542
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Ala Glu Asn Val Thr Gly Leu Phe Lys Asp Cys Ser Lys Val Ile 
1               5                   10                  15      


Thr Gly Leu His Pro Thr Gln Ala Pro Thr His Leu Ser Val Asp Thr 
            20                  25                  30          


Lys Phe Lys Thr Glu Gly Leu Cys Val Asp Ile Pro Gly Ile Pro Lys 
        35                  40                  45              


Asp Met Thr Tyr Arg Arg Leu Ile Ser Met Met Gly Phe Lys Met Asn 
    50                  55                  60                  


Tyr Gln Val Asn Gly Tyr Pro Asn Met Phe Ile Thr Arg Glu Glu Ala 
65                  70                  75                  80  


Ile Arg His Val Arg Ala Trp Ile Gly Phe Asp Val Glu Gly Cys His 
                85                  90                  95      


Ala Thr Arg Glu Ala Val Gly Thr Asn Leu Pro Leu Gln Leu Gly Phe 
            100                 105                 110         


Ser Thr Gly Val Asn Leu Val Ala Val Pro Thr Gly Tyr Val Asp Thr 
        115                 120                 125             


Pro Asn Asn Thr Asp Phe Ser Arg Val Ser Ala Lys Pro Pro Pro Gly 
    130                 135                 140                 


Asp Gln Phe Lys His Leu Ile Pro Leu Met Tyr Lys Gly Leu Pro Trp 
145                 150                 155                 160 


Asn Val Val Arg Ile Lys Ile Val Gln Met Leu Ser Asp Thr Leu Lys 
                165                 170                 175     


Asn Leu Ser Asp Arg Val Val Phe Val Leu Trp Ala His Gly Phe Glu 
            180                 185                 190         


Leu Thr Ser Met Lys Tyr Phe Val Lys Ile Gly Pro Glu Arg Thr Cys 
        195                 200                 205             


Cys Leu Cys Asp Arg Arg Ala Thr Cys Phe Ser Thr Ala Ser Asp Thr 
    210                 215                 220                 


Tyr Ala Cys Trp His His Ser Ile Gly Phe Asp Tyr Val Tyr Asn Pro 
225                 230                 235                 240 


Phe Met Ile Asp Val Gln Gln Trp Gly Phe Thr Gly Asn Leu Gln Ser 
                245                 250                 255     


Asn His Asp Leu Tyr Cys Gln Val His Gly Asn Ala His Val Ala Ser 
            260                 265                 270         


Cys Asp Ala Ile Met Thr Arg Cys Leu Ala Val His Glu Cys Phe Val 
        275                 280                 285             


Lys Arg Val Asp Trp Thr Ile Glu Tyr Pro Ile Ile Gly Asp Glu Leu 
    290                 295                 300                 


Lys Ile Asn Ala Ala Cys Arg Lys Val Gln His Met Val Val Lys Ala 
305                 310                 315                 320 


Ala Leu Leu Ala Asp Lys Phe Pro Val Leu His Asp Ile Gly Asn Pro 
                325                 330                 335     


Lys Ala Ile Lys Cys Val Pro Gln Ala Asp Val Glu Trp Lys Phe Tyr 
            340                 345                 350         


Asp Ala Gln Pro Cys Ser Asp Lys Ala Tyr Lys Ile Glu Glu Leu Phe 
        355                 360                 365             


Tyr Ser Tyr Ala Thr His Ser Asp Lys Phe Thr Asp Gly Val Cys Leu 
    370                 375                 380                 


Phe Trp Asn Cys Asn Val Asp Arg Tyr Pro Ala Asn Ser Ile Val Cys 
385                 390                 395                 400 


Arg Phe Asp Thr Arg Val Leu Ser Asn Leu Asn Leu Pro Gly Cys Asp 
                405                 410                 415     


Gly Gly Ser Leu Tyr Val Asn Lys His Ala Phe His Thr Pro Ala Phe 
            420                 425                 430         


Asp Lys Ser Ala Phe Val Asn Leu Lys Gln Leu Pro Phe Phe Tyr Tyr 
        435                 440                 445             


Ser Asp Ser Pro Cys Glu Ser His Gly Lys Gln Val Val Ser Asp Ile 
    450                 455                 460                 


Asp Tyr Val Pro Leu Lys Ser Ala Thr Cys Ile Thr Arg Cys Asn Leu 
465                 470                 475                 480 


Gly Gly Ala Val Cys Arg His His Ala Asn Glu Tyr Arg Leu Tyr Leu 
                485                 490                 495     


Asp Ala Tyr Asn Met Met Ile Ser Ala Gly Phe Ser Leu Trp Val Tyr 
            500                 505                 510         


Lys Gln Phe Asp Thr Tyr Asn Leu Trp Asn Thr Phe Thr Arg Leu Gln 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Ser His His His His His His 
    530                 535                 540         


<210> 17
<211> 465
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
atggctggta atgctacgga agtcccggca aatagtacgg tgctgtcgtt ctgtgcgttc       60

gctgttgatg cggcaaaagc ctacaaagat tatctggcca gtggcggtca gccgattacg      120

aactgcgtta aaatgctgtg tacccatacc ggtaccggtc aggccatcac cgtcaccccg      180

gaagccaata tggaccaaga atcttttggc ggtgcatctt gctgtctgta ttgccgttgt      240

catattgatc acccgaaccc gaaaggcttc tgcgacctga agggtaaata cgtccagatc      300

ccgaccacgt gtgctaacga tccggtgggc tttaccctga aaaatacggt gtgcaccgtt      360

tgtggcatgt ggaaaggcta cggttgcagc tgtgaccaac tgcgcgaacc gatgctgcaa      420

ggcggcggct caggcggcgg ctcacaccac caccaccatc attaa                      465


<210> 18
<211> 154
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Ala Gly Asn Ala Thr Glu Val Pro Ala Asn Ser Thr Val Leu Ser 
1               5                   10                  15      


Phe Cys Ala Phe Ala Val Asp Ala Ala Lys Ala Tyr Lys Asp Tyr Leu 
            20                  25                  30          


Ala Ser Gly Gly Gln Pro Ile Thr Asn Cys Val Lys Met Leu Cys Thr 
        35                  40                  45              


His Thr Gly Thr Gly Gln Ala Ile Thr Val Thr Pro Glu Ala Asn Met 
    50                  55                  60                  


Asp Gln Glu Ser Phe Gly Gly Ala Ser Cys Cys Leu Tyr Cys Arg Cys 
65                  70                  75                  80  


His Ile Asp His Pro Asn Pro Lys Gly Phe Cys Asp Leu Lys Gly Lys 
                85                  90                  95      


Tyr Val Gln Ile Pro Thr Thr Cys Ala Asn Asp Pro Val Gly Phe Thr 
            100                 105                 110         


Leu Lys Asn Thr Val Cys Thr Val Cys Gly Met Trp Lys Gly Tyr Gly 
        115                 120                 125             


Cys Ser Cys Asp Gln Leu Arg Glu Pro Met Leu Gln Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Ser His His His His His His 
145                 150                 


<210> 19
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
uaaggcgcuu aauucggcaa                                                   20


<210> 20
<211> 1629
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
atggctgaaa atgtaacagg actatttaaa gactgttcca aaatcatcac cggcctgcat       60

ccgacccagg caccgactca cctgtccgtg gatatcaaat ttaaaaccga gggtctgtgc      120

gtggatattc cgggtattcc gaaagatatg acctaccgtc gtctgatttc tatgatgggt      180

ttcaagatga attatcaggt taatggttac ccgaatatgt tcatcacgcg tgaagaggca      240

attcgtcatg ttcgtgcttg gattggattc gacgttgaag gctgccatgc taccagagat      300

gctgtgggta caaaccttcc actgcaactg ggtttctcga ccggggtgaa cttggttgct      360

gtcccaacgg gctacgtgga cactgagaac aacaccgagt tcacccgagt taatgcgaaa      420

ccgcctccgg gcgaccagtt taaacacctg atcccgttga tgtataaagg tctgccgtgg      480

aatgttgtgc gtattaagat cgtacaaatg ctgtccgaca ccctgaaggg tcttagcgac      540

cgcgttgtct ttgtgctgtg ggcacatggc ttcgaattga ccagcatgaa atacttcgtg      600

aaaatcggtc cggagcgtac ctgctgtctg tgtgataagc gcgcgacgtg ctttagcacc      660

tctagcgaca cttacgcctg ttggaaccac agcgtaggct tcgactacgt gtataaccca      720

tttatgatcg atgtgcagca gtggggtttc accggtaacc tgcaaagcaa ccacgatcag      780

cattgtcagg ttcacggcaa cgcgcatgtt gccagctgtg atgcgatcat gactcgttgc      840

ctggcggtcc acgagtgctt tgttaaacgt gttgactggt ccgtcgagta cccgattatc      900

ggcgacgaac tgcgtgtgaa cagcgcgtgc cgtaaagtcc agcacatggt tgtgaagtcc      960

gcgctcctgg ccgataagtt cccggttctg cacgacatcg gcaacccgaa agcaatcaag     1020

tgcgtaccgc aggcggaagt tgagtggaaa ttttacgatg cgcagccgtg cagcgacaag     1080

gcgtacaaga ttgaagagtt gttctacagt tatgctacgc atcacgataa gtttaccgat     1140

ggtgtgtgct tgttttggaa ctgcaacgtc gaccgttatc cggcgaatgc cattgtttgt     1200

cgctttgata cccgcgtgtt gtctaatttg aatttacccg ggtgcgacgg cggttcgctg     1260

tatgtgaaca aacatgcgtt ccataccccg gcattcgata agtcagcctt caccaatctc     1320

aagcaactgc cgttttttta ttatagcgac agcccgtgcg aaagccatgg taaacaagtc     1380

gttagcgaca tcgactacgt gccgttgaag agcgcgacat gcatcacccg ttgtaacttg     1440

ggcggtgccg tgtgccgcca tcacgcgaat gaataccgcc agtatctgga tgcgtataac     1500

atgatgatta gcgcgggttt ctctctgtgg atttataagc aattcgacac gtacaactta     1560

tggaacacct ttacccgcct gcaaggtggc ggctctggtg gcggctccca ccaccaccac     1620

caccactaa                                                             1629


<210> 21
<211> 542
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Ala Glu Asn Val Thr Gly Leu Phe Lys Asp Cys Ser Lys Ile Ile 
1               5                   10                  15      


Thr Gly Leu His Pro Thr Gln Ala Pro Thr His Leu Ser Val Asp Ile 
            20                  25                  30          


Lys Phe Lys Thr Glu Gly Leu Cys Val Asp Ile Pro Gly Ile Pro Lys 
        35                  40                  45              


Asp Met Thr Tyr Arg Arg Leu Ile Ser Met Met Gly Phe Lys Met Asn 
    50                  55                  60                  


Tyr Gln Val Asn Gly Tyr Pro Asn Met Phe Ile Thr Arg Glu Glu Ala 
65                  70                  75                  80  


Ile Arg His Val Arg Ala Trp Ile Gly Phe Asp Val Glu Gly Cys His 
                85                  90                  95      


Ala Thr Arg Asp Ala Val Gly Thr Asn Leu Pro Leu Gln Leu Gly Phe 
            100                 105                 110         


Ser Thr Gly Val Asn Leu Val Ala Val Pro Thr Gly Tyr Val Asp Thr 
        115                 120                 125             


Glu Asn Asn Thr Glu Phe Thr Arg Val Asn Ala Lys Pro Pro Pro Gly 
    130                 135                 140                 


Asp Gln Phe Lys His Leu Ile Pro Leu Met Tyr Lys Gly Leu Pro Trp 
145                 150                 155                 160 


Asn Val Val Arg Ile Lys Ile Val Gln Met Leu Ser Asp Thr Leu Lys 
                165                 170                 175     


Gly Leu Ser Asp Arg Val Val Phe Val Leu Trp Ala His Gly Phe Glu 
            180                 185                 190         


Leu Thr Ser Met Lys Tyr Phe Val Lys Ile Gly Pro Glu Arg Thr Cys 
        195                 200                 205             


Cys Leu Cys Asp Lys Arg Ala Thr Cys Phe Ser Thr Ser Ser Asp Thr 
    210                 215                 220                 


Tyr Ala Cys Trp Asn His Ser Val Gly Phe Asp Tyr Val Tyr Asn Pro 
225                 230                 235                 240 


Phe Met Ile Asp Val Gln Gln Trp Gly Phe Thr Gly Asn Leu Gln Ser 
                245                 250                 255     


Asn His Asp Gln His Cys Gln Val His Gly Asn Ala His Val Ala Ser 
            260                 265                 270         


Cys Asp Ala Ile Met Thr Arg Cys Leu Ala Val His Glu Cys Phe Val 
        275                 280                 285             


Lys Arg Val Asp Trp Ser Val Glu Tyr Pro Ile Ile Gly Asp Glu Leu 
    290                 295                 300                 


Arg Val Asn Ser Ala Cys Arg Lys Val Gln His Met Val Val Lys Ser 
305                 310                 315                 320 


Ala Leu Leu Ala Asp Lys Phe Pro Val Leu His Asp Ile Gly Asn Pro 
                325                 330                 335     


Lys Ala Ile Lys Cys Val Pro Gln Ala Glu Val Glu Trp Lys Phe Tyr 
            340                 345                 350         


Asp Ala Gln Pro Cys Ser Asp Lys Ala Tyr Lys Ile Glu Glu Leu Phe 
        355                 360                 365             


Tyr Ser Tyr Ala Thr His His Asp Lys Phe Thr Asp Gly Val Cys Leu 
    370                 375                 380                 


Phe Trp Asn Cys Asn Val Asp Arg Tyr Pro Ala Asn Ala Ile Val Cys 
385                 390                 395                 400 


Arg Phe Asp Thr Arg Val Leu Ser Asn Leu Asn Leu Pro Gly Cys Asp 
                405                 410                 415     


Gly Gly Ser Leu Tyr Val Asn Lys His Ala Phe His Thr Pro Ala Phe 
            420                 425                 430         


Asp Lys Ser Ala Phe Thr Asn Leu Lys Gln Leu Pro Phe Phe Tyr Tyr 
        435                 440                 445             


Ser Asp Ser Pro Cys Glu Ser His Gly Lys Gln Val Val Ser Asp Ile 
    450                 455                 460                 


Asp Tyr Val Pro Leu Lys Ser Ala Thr Cys Ile Thr Arg Cys Asn Leu 
465                 470                 475                 480 


Gly Gly Ala Val Cys Arg His His Ala Asn Glu Tyr Arg Gln Tyr Leu 
                485                 490                 495     


Asp Ala Tyr Asn Met Met Ile Ser Ala Gly Phe Ser Leu Trp Ile Tyr 
            500                 505                 510         


Lys Gln Phe Asp Thr Tyr Asn Leu Trp Asn Thr Phe Thr Arg Leu Gln 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Ser His His His His His His 
    530                 535                 540         


<210> 22
<211> 465
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
atggcaggaa atgcgacaga agtacccgct aacagcaccg tcctgagctt ctgcgcgttt       60

gcagttgatc cagcgaaggc gtataaagat tacttggctt ccggcggcca accgattacc      120

aattgcgtga agatgctgtg tacccatact ggtacaggcc aagcgatcac ggttaccccg      180

gaagccaaca tggatcaaga gtcgttcggc ggcgcatctt gttgcctgta ctgccgttgt      240

catatcgacc atccgaatcc gaaaggcttt tgcgacttaa agggtaaata cgtgcagatt      300

ccgaccacgt gcgctaacga cccggttggt ttcaccttgc gcaacaccgt atgcaccgtg      360

tgcggtatgt ggaaaggtta tggttgtagc tgcgaccagc tgcgtgagcc gctgatgcag      420

ggtggcggtt ccggtggtgg cagccatcac caccaccacc actaa                      465


<210> 23
<211> 154
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Ala Gly Asn Ala Thr Glu Val Pro Ala Asn Ser Thr Val Leu Ser 
1               5                   10                  15      


Phe Cys Ala Phe Ala Val Asp Pro Ala Lys Ala Tyr Lys Asp Tyr Leu 
            20                  25                  30          


Ala Ser Gly Gly Gln Pro Ile Thr Asn Cys Val Lys Met Leu Cys Thr 
        35                  40                  45              


His Thr Gly Thr Gly Gln Ala Ile Thr Val Thr Pro Glu Ala Asn Met 
    50                  55                  60                  


Asp Gln Glu Ser Phe Gly Gly Ala Ser Cys Cys Leu Tyr Cys Arg Cys 
65                  70                  75                  80  


His Ile Asp His Pro Asn Pro Lys Gly Phe Cys Asp Leu Lys Gly Lys 
                85                  90                  95      


Tyr Val Gln Ile Pro Thr Thr Cys Ala Asn Asp Pro Val Gly Phe Thr 
            100                 105                 110         


Leu Arg Asn Thr Val Cys Thr Val Cys Gly Met Trp Lys Gly Tyr Gly 
        115                 120                 125             


Cys Ser Cys Asp Gln Leu Arg Glu Pro Leu Met Gln Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Ser His His His His His His 
145                 150                 


<210> 24
<211> 1620
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
atgtcacaaa tagtaacagg actatttaaa gattgtagcc gtgagaccag cggcttgtcc       60

ccggcgtacg caccgaccta tgtgagcgtt gatgataaat acaagacctc tgatgaactt      120

tgcgtgaact tgaatttacc ggctaatgtc ccgtacagtc gtgttattag ccgcatgggc      180

ttcaaattag acgctacggt tccgggctac ccgaaactat tcatcacccg ggaggaagcg      240

gttcgtcagg ttcgtagctg gatcggtttc gatgtggaag gtgcccacgc ctcgcgcaac      300

gcctgcggta caaatgttcc gctgcagctg ggtttcagca ccggtgttaa ttttgttgtc      360

caaccagtgg gcgtggtcga caccgagtgg ggtaacatgc tgacgggtat cgccgctcgc      420

ccacccccgg gtgaacagtt taagcacctg gttccgctga tgcataaagg tgcggcgtgg      480

cctattgtgc gccgtcgtat tgtacaaatg ttgtcggaca cgctggataa gttgtccgac      540

tactgtacct tcgtgtgctg ggcacacggc ttcgagctga cctctgcgtc ctacttctgc      600

aaaatcggca aagagcagaa atgttgcatg tgtaaccgtc gcgctgctgc gtacagcagc      660

ccgctgcaaa gctatgcgtg ctggacccac tcttgcggtt acgattatgt ctataacccg      720

ttttttgtcg acgttcaaca gtggggttac gtaggcaacc tggcgactaa ccacgatcgt      780

tattgcagcg tgcaccaggg tgcgcacgtg gcctcaaatg atgcgatcat gacccgttgc      840

ctggcgattc atagctgctt tatcgagcgc gtggactggg atatcgaata cccgtatatc      900

agccatgaaa aaaaactgaa cagctgctgc cgtattgtcg aacgcaatgt ggtacgtgca      960

gcgctgctgg cgggtagctt tgacaaggtc tacgatatcg gtaacccgaa gggcatcccg     1020

attgttgacg atccggttgt ggactggcat tattttgacg cccagccgtt gacccgcaaa     1080

gtgcaacaac tgttctacac tgaggatatg gcaagccgtt ttgcggatgg tctctgcctg     1140

ttctggaatt gtaacgttcc gaagtaccca aataacgcaa ttgtttgccg ttttgacact     1200

cgcgttcaca gcgaattcaa cctgccgggg tgcgacggcg gttcgctgta tgtgaataag     1260

catgcgtttc ataccccggc gtacgacgtg tctgcgtttc gtgatctgaa gccgctcccg     1320

tttttctatt actccacgac cccgtgtgaa gttcatggta acggttctat gattgaggac     1380

atcgactacg tgccgcttaa gagcgcggtt tgcattaccg catgcaactt aggaggcgcg     1440

gtgtgtcgta agcacgcaac cgagtatcgt gagtatatgg aagcgtacaa cttggtttcc     1500

gcttccggct tccgcctgtg gtgttacaag acgttcgaca tctataacct gtggtccacc     1560

ttcaccaaag ttcagggcgg cggctcgggt ggcggcagcc atcaccacca tcaccactaa     1620


<210> 25
<211> 539
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Ser Gln Ile Val Thr Gly Leu Phe Lys Asp Cys Ser Arg Glu Thr 
1               5                   10                  15      


Ser Gly Leu Ser Pro Ala Tyr Ala Pro Thr Tyr Val Ser Val Asp Asp 
            20                  25                  30          


Lys Tyr Lys Thr Ser Asp Glu Leu Cys Val Asn Leu Asn Leu Pro Ala 
        35                  40                  45              


Asn Val Pro Tyr Ser Arg Val Ile Ser Arg Met Gly Phe Lys Leu Asp 
    50                  55                  60                  


Ala Thr Val Pro Gly Tyr Pro Lys Leu Phe Ile Thr Arg Glu Glu Ala 
65                  70                  75                  80  


Val Arg Gln Val Arg Ser Trp Ile Gly Phe Asp Val Glu Gly Ala His 
                85                  90                  95      


Ala Ser Arg Asn Ala Cys Gly Thr Asn Val Pro Leu Gln Leu Gly Phe 
            100                 105                 110         


Ser Thr Gly Val Asn Phe Val Val Gln Pro Val Gly Val Val Asp Thr 
        115                 120                 125             


Glu Trp Gly Asn Met Leu Thr Gly Ile Ala Ala Arg Pro Pro Pro Gly 
    130                 135                 140                 


Glu Gln Phe Lys His Leu Val Pro Leu Met His Lys Gly Ala Ala Trp 
145                 150                 155                 160 


Pro Ile Val Arg Arg Arg Ile Val Gln Met Leu Ser Asp Thr Leu Asp 
                165                 170                 175     


Lys Leu Ser Asp Tyr Cys Thr Phe Val Cys Trp Ala His Gly Phe Glu 
            180                 185                 190         


Leu Thr Ser Ala Ser Tyr Phe Cys Lys Ile Gly Lys Glu Gln Lys Cys 
        195                 200                 205             


Cys Met Cys Asn Arg Arg Ala Ala Ala Tyr Ser Ser Pro Leu Gln Ser 
    210                 215                 220                 


Tyr Ala Cys Trp Thr His Ser Cys Gly Tyr Asp Tyr Val Tyr Asn Pro 
225                 230                 235                 240 


Phe Phe Val Asp Val Gln Gln Trp Gly Tyr Val Gly Asn Leu Ala Thr 
                245                 250                 255     


Asn His Asp Arg Tyr Cys Ser Val His Gln Gly Ala His Val Ala Ser 
            260                 265                 270         


Asn Asp Ala Ile Met Thr Arg Cys Leu Ala Ile His Ser Cys Phe Ile 
        275                 280                 285             


Glu Arg Val Asp Trp Asp Ile Glu Tyr Pro Tyr Ile Ser His Glu Lys 
    290                 295                 300                 


Lys Leu Asn Ser Cys Cys Arg Ile Val Glu Arg Asn Val Val Arg Ala 
305                 310                 315                 320 


Ala Leu Leu Ala Gly Ser Phe Asp Lys Val Tyr Asp Ile Gly Asn Pro 
                325                 330                 335     


Lys Gly Ile Pro Ile Val Asp Asp Pro Val Val Asp Trp His Tyr Phe 
            340                 345                 350         


Asp Ala Gln Pro Leu Thr Arg Lys Val Gln Gln Leu Phe Tyr Thr Glu 
        355                 360                 365             


Asp Met Ala Ser Arg Phe Ala Asp Gly Leu Cys Leu Phe Trp Asn Cys 
    370                 375                 380                 


Asn Val Pro Lys Tyr Pro Asn Asn Ala Ile Val Cys Arg Phe Asp Thr 
385                 390                 395                 400 


Arg Val His Ser Glu Phe Asn Leu Pro Gly Cys Asp Gly Gly Ser Leu 
                405                 410                 415     


Tyr Val Asn Lys His Ala Phe His Thr Pro Ala Tyr Asp Val Ser Ala 
            420                 425                 430         


Phe Arg Asp Leu Lys Pro Leu Pro Phe Phe Tyr Tyr Ser Thr Thr Pro 
        435                 440                 445             


Cys Glu Val His Gly Asn Gly Ser Met Ile Glu Asp Ile Asp Tyr Val 
    450                 455                 460                 


Pro Leu Lys Ser Ala Val Cys Ile Thr Ala Cys Asn Leu Gly Gly Ala 
465                 470                 475                 480 


Val Cys Arg Lys His Ala Thr Glu Tyr Arg Glu Tyr Met Glu Ala Tyr 
                485                 490                 495     


Asn Leu Val Ser Ala Ser Gly Phe Arg Leu Trp Cys Tyr Lys Thr Phe 
            500                 505                 510         


Asp Ile Tyr Asn Leu Trp Ser Thr Phe Thr Lys Val Gln Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser His His His His His His 
    530                 535                 


<210> 26
<211> 468
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
atggctggat caaatacaga atttgcaagt aacagctcgg tgctttcttt ggttaacttc       60

accgtagatc cgcaaaaagc gtatctggac ttcgtgaacg ccggtggtgc tccgctgacc      120

aattgcgtga agatgctgac gccaaagacc ggcaccggta ttgcgatcag cgtgaagccg      180

gaaagcaccg ctgaccaaga gacgtacggc ggcgcgagcg tctgcctgta ctgccgtgca      240

catatcgagc atccggatgt tagcggggtg tgcaaataca aaggtaaatt tgtccagatc      300

ccggcgcagt gtgttcgtga tcctgttggt ttttgcctga gcaatactcc gtgtaatgtt      360

tgccagtatt ggattggtta tggttgtaac tgcgactctt tgcgccaggc ggcactgccg      420

caaggtggcg gctccggcgg tggctcccat caccaccacc accactaa                   468


<210> 27
<211> 155
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Ala Gly Ser Asn Thr Glu Phe Ala Ser Asn Ser Ser Val Leu Ser 
1               5                   10                  15      


Leu Val Asn Phe Thr Val Asp Pro Gln Lys Ala Tyr Leu Asp Phe Val 
            20                  25                  30          


Asn Ala Gly Gly Ala Pro Leu Thr Asn Cys Val Lys Met Leu Thr Pro 
        35                  40                  45              


Lys Thr Gly Thr Gly Ile Ala Ile Ser Val Lys Pro Glu Ser Thr Ala 
    50                  55                  60                  


Asp Gln Glu Thr Tyr Gly Gly Ala Ser Val Cys Leu Tyr Cys Arg Ala 
65                  70                  75                  80  


His Ile Glu His Pro Asp Val Ser Gly Val Cys Lys Tyr Lys Gly Lys 
                85                  90                  95      


Phe Val Gln Ile Pro Ala Gln Cys Val Arg Asp Pro Val Gly Phe Cys 
            100                 105                 110         


Leu Ser Asn Thr Pro Cys Asn Val Cys Gln Tyr Trp Ile Gly Tyr Gly 
        115                 120                 125             


Cys Asn Cys Asp Ser Leu Arg Gln Ala Ala Leu Pro Gln Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser His His His His His His 
145                 150                 155 


