                               SEQUENCE LISTING

<110> MAMMOTH BIOSCIENCES, INC.
 
<120> COMPOSITIONS AND METHODS OF USING PROGRAMMABLE NUCLEASES FOR 
      INDUCING CELL DEATH

<130> 53694-767.601

<140>
<141>

<150> 63/239,338
<151> 2021-08-31

<150> 63/129,898
<151> 2020-12-23

<160> 285   

<170> PatentIn version 3.5

<210> 1
<211> 1228
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Lachnospiraceae bacterium ND2006 sequence

<400> 1
Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210> 2
<211> 1307
<212> PRT
<213> Acidaminococcus sp.

<400> 2
Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210> 3
<211> 1300
<212> PRT
<213> Francisella sp.

<400> 3
Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210> 4
<211> 1246
<212> PRT
<213> Porphyromonas macacae

<400> 4
Met Lys Thr Gln His Phe Phe Glu Asp Phe Thr Ser Leu Tyr Ser Leu 
1               5                   10                  15      


Ser Lys Thr Ile Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Leu Glu 
            20                  25                  30          


Asn Ile Lys Lys Asn Gly Leu Ile Arg Arg Asp Glu Gln Arg Leu Asp 
        35                  40                  45              


Asp Tyr Glu Lys Leu Lys Lys Val Ile Asp Glu Tyr His Glu Asp Phe 
    50                  55                  60                  


Ile Ala Asn Ile Leu Ser Ser Phe Ser Phe Ser Glu Glu Ile Leu Gln 
65                  70                  75                  80  


Ser Tyr Ile Gln Asn Leu Ser Glu Ser Glu Ala Arg Ala Lys Ile Glu 
                85                  90                  95      


Lys Thr Met Arg Asp Thr Leu Ala Lys Ala Phe Ser Glu Asp Glu Arg 
            100                 105                 110         


Tyr Lys Ser Ile Phe Lys Lys Glu Leu Val Lys Lys Asp Ile Pro Val 
        115                 120                 125             


Trp Cys Pro Ala Tyr Lys Ser Leu Cys Lys Lys Phe Asp Asn Phe Thr 
    130                 135                 140                 


Thr Ser Leu Val Pro Phe His Glu Asn Arg Lys Asn Leu Tyr Thr Ser 
145                 150                 155                 160 


Asn Glu Ile Thr Ala Ser Ile Pro Tyr Arg Ile Val His Val Asn Leu 
                165                 170                 175     


Pro Lys Phe Ile Gln Asn Ile Glu Ala Leu Cys Glu Leu Gln Lys Lys 
            180                 185                 190         


Met Gly Ala Asp Leu Tyr Leu Glu Met Met Glu Asn Leu Arg Asn Val 
        195                 200                 205             


Trp Pro Ser Phe Val Lys Thr Pro Asp Asp Leu Cys Asn Leu Lys Thr 
    210                 215                 220                 


Tyr Asn His Leu Met Val Gln Ser Ser Ile Ser Glu Tyr Asn Arg Phe 
225                 230                 235                 240 


Val Gly Gly Tyr Ser Thr Glu Asp Gly Thr Lys His Gln Gly Ile Asn 
                245                 250                 255     


Glu Trp Ile Asn Ile Tyr Arg Gln Arg Asn Lys Glu Met Arg Leu Pro 
            260                 265                 270         


Gly Leu Val Phe Leu His Lys Gln Ile Leu Ala Lys Val Asp Ser Ser 
        275                 280                 285             


Ser Phe Ile Ser Asp Thr Leu Glu Asn Asp Asp Gln Val Phe Cys Val 
    290                 295                 300                 


Leu Arg Gln Phe Arg Lys Leu Phe Trp Asn Thr Val Ser Ser Lys Glu 
305                 310                 315                 320 


Asp Asp Ala Ala Ser Leu Lys Asp Leu Phe Cys Gly Leu Ser Gly Tyr 
                325                 330                 335     


Asp Pro Glu Ala Ile Tyr Val Ser Asp Ala His Leu Ala Thr Ile Ser 
            340                 345                 350         


Lys Asn Ile Phe Asp Arg Trp Asn Tyr Ile Ser Asp Ala Ile Arg Arg 
        355                 360                 365             


Lys Thr Glu Val Leu Met Pro Arg Lys Lys Glu Ser Val Glu Arg Tyr 
    370                 375                 380                 


Ala Glu Lys Ile Ser Lys Gln Ile Lys Lys Arg Gln Ser Tyr Ser Leu 
385                 390                 395                 400 


Ala Glu Leu Asp Asp Leu Leu Ala His Tyr Ser Glu Glu Ser Leu Pro 
                405                 410                 415     


Ala Gly Phe Ser Leu Leu Ser Tyr Phe Thr Ser Leu Gly Gly Gln Lys 
            420                 425                 430         


Tyr Leu Val Ser Asp Gly Glu Val Ile Leu Tyr Glu Glu Gly Ser Asn 
        435                 440                 445             


Ile Trp Asp Glu Val Leu Ile Ala Phe Arg Asp Leu Gln Val Ile Leu 
    450                 455                 460                 


Asp Lys Asp Phe Thr Glu Lys Lys Leu Gly Lys Asp Glu Glu Ala Val 
465                 470                 475                 480 


Ser Val Ile Lys Lys Ala Leu Asp Ser Ala Leu Arg Leu Arg Lys Phe 
                485                 490                 495     


Phe Asp Leu Leu Ser Gly Thr Gly Ala Glu Ile Arg Arg Asp Ser Ser 
            500                 505                 510         


Phe Tyr Ala Leu Tyr Thr Asp Arg Met Asp Lys Leu Lys Gly Leu Leu 
        515                 520                 525             


Lys Met Tyr Asp Lys Val Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser 
    530                 535                 540                 


Ile Glu Lys Phe Lys Leu His Phe Asp Asn Pro Ser Leu Leu Ser Gly 
545                 550                 555                 560 


Trp Asp Lys Asn Lys Glu Leu Asn Asn Leu Ser Val Ile Phe Arg Gln 
                565                 570                 575     


Asn Gly Tyr Tyr Tyr Leu Gly Ile Met Thr Pro Lys Gly Lys Asn Leu 
            580                 585                 590         


Phe Lys Thr Leu Pro Lys Leu Gly Ala Glu Glu Met Phe Tyr Glu Lys 
        595                 600                 605             


Met Glu Tyr Lys Gln Ile Ala Glu Pro Met Leu Met Leu Pro Lys Val 
    610                 615                 620                 


Phe Phe Pro Lys Lys Thr Lys Pro Ala Phe Ala Pro Asp Gln Ser Val 
625                 630                 635                 640 


Val Asp Ile Tyr Asn Lys Lys Thr Phe Lys Thr Gly Gln Lys Gly Phe 
                645                 650                 655     


Asn Lys Lys Asp Leu Tyr Arg Leu Ile Asp Phe Tyr Lys Glu Ala Leu 
            660                 665                 670         


Thr Val His Glu Trp Lys Leu Phe Asn Phe Ser Phe Ser Pro Thr Glu 
        675                 680                 685             


Gln Tyr Arg Asn Ile Gly Glu Phe Phe Asp Glu Val Arg Glu Gln Ala 
    690                 695                 700                 


Tyr Lys Val Ser Met Val Asn Val Pro Ala Ser Tyr Ile Asp Glu Ala 
705                 710                 715                 720 


Val Glu Asn Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe 
                725                 730                 735     


Ser Pro Tyr Ser Lys Gly Ile Pro Asn Leu His Thr Leu Tyr Trp Lys 
            740                 745                 750         


Ala Leu Phe Ser Glu Gln Asn Gln Ser Arg Val Tyr Lys Leu Cys Gly 
        755                 760                 765             


Gly Gly Glu Leu Phe Tyr Arg Lys Ala Ser Leu His Met Gln Asp Thr 
    770                 775                 780                 


Thr Val His Pro Lys Gly Ile Ser Ile His Lys Lys Asn Leu Asn Lys 
785                 790                 795                 800 


Lys Gly Glu Thr Ser Leu Phe Asn Tyr Asp Leu Val Lys Asp Lys Arg 
                805                 810                 815     


Phe Thr Glu Asp Lys Phe Phe Phe His Val Pro Ile Ser Ile Asn Tyr 
            820                 825                 830         


Lys Asn Lys Lys Ile Thr Asn Val Asn Gln Met Val Arg Asp Tyr Ile 
        835                 840                 845             


Ala Gln Asn Asp Asp Leu Gln Ile Ile Gly Ile Asp Arg Gly Glu Arg 
    850                 855                 860                 


Asn Leu Leu Tyr Ile Ser Arg Ile Asp Thr Arg Gly Asn Leu Leu Glu 
865                 870                 875                 880 


Gln Phe Ser Leu Asn Val Ile Glu Ser Asp Lys Gly Asp Leu Arg Thr 
                885                 890                 895     


Asp Tyr Gln Lys Ile Leu Gly Asp Arg Glu Gln Glu Arg Leu Arg Arg 
            900                 905                 910         


Arg Gln Glu Trp Lys Ser Ile Glu Ser Ile Lys Asp Leu Lys Asp Gly 
        915                 920                 925             


Tyr Met Ser Gln Val Val His Lys Ile Cys Asn Met Val Val Glu His 
    930                 935                 940                 


Lys Ala Ile Val Val Leu Glu Asn Leu Asn Leu Ser Phe Met Lys Gly 
945                 950                 955                 960 


Arg Lys Lys Val Glu Lys Ser Val Tyr Glu Lys Phe Glu Arg Met Leu 
                965                 970                 975     


Val Asp Lys Leu Asn Tyr Leu Val Val Asp Lys Lys Asn Leu Ser Asn 
            980                 985                 990         


Glu Pro Gly Gly Leu Tyr Ala Ala  Tyr Gln Leu Thr Asn  Pro Leu Phe 
        995                 1000                 1005             


Ser Phe  Glu Glu Leu His Arg  Tyr Pro Gln Ser Gly  Ile Leu Phe 
    1010                 1015                 1020             


Phe Val  Asp Pro Trp Asn Thr  Ser Leu Thr Asp Pro  Ser Thr Gly 
    1025                 1030                 1035             


Phe Val  Asn Leu Leu Gly Arg  Ile Asn Tyr Thr Asn  Val Gly Asp 
    1040                 1045                 1050             


Ala Arg  Lys Phe Phe Asp Arg  Phe Asn Ala Ile Arg  Tyr Asp Gly 
    1055                 1060                 1065             


Lys Gly  Asn Ile Leu Phe Asp  Leu Asp Leu Ser Arg  Phe Asp Val 
    1070                 1075                 1080             


Arg Val  Glu Thr Gln Arg Lys  Leu Trp Thr Leu Thr  Thr Phe Gly 
    1085                 1090                 1095             


Ser Arg  Ile Ala Lys Ser Lys  Lys Ser Gly Lys Trp  Met Val Glu 
    1100                 1105                 1110             


Arg Ile  Glu Asn Leu Ser Leu  Cys Phe Leu Glu Leu  Phe Glu Gln 
    1115                 1120                 1125             


Phe Asn  Ile Gly Tyr Arg Val  Glu Lys Asp Leu Lys  Lys Ala Ile 
    1130                 1135                 1140             


Leu Ser  Gln Asp Arg Lys Glu  Phe Tyr Val Arg Leu  Ile Tyr Leu 
    1145                 1150                 1155             


Phe Asn  Leu Met Met Gln Ile  Arg Asn Ser Asp Gly  Glu Glu Asp 
    1160                 1165                 1170             


Tyr Ile  Leu Ser Pro Ala Leu  Asn Glu Lys Asn Leu  Gln Phe Asp 
    1175                 1180                 1185             


Ser Arg  Leu Ile Glu Ala Lys  Asp Leu Pro Val Asp  Ala Asp Ala 
    1190                 1195                 1200             


Asn Gly  Ala Tyr Asn Val Ala  Arg Lys Gly Leu Met  Val Val Gln 
    1205                 1210                 1215             


Arg Ile  Lys Arg Gly Asp His  Glu Ser Ile His Arg  Ile Gly Arg 
    1220                 1225                 1230             


Ala Gln  Trp Leu Arg Tyr Val  Gln Glu Gly Ile Val  Glu 
    1235                 1240                 1245     


<210> 5
<211> 1373
<212> PRT
<213> Moraxella bovoculi

<400> 5
Met Leu Phe Gln Asp Phe Thr His Leu Tyr Pro Leu Ser Lys Thr Val 
1               5                   10                  15      


Arg Phe Glu Leu Lys Pro Ile Asp Arg Thr Leu Glu His Ile His Ala 
            20                  25                  30          


Lys Asn Phe Leu Ser Gln Asp Glu Thr Met Ala Asp Met His Gln Lys 
        35                  40                  45              


Val Lys Val Ile Leu Asp Asp Tyr His Arg Asp Phe Ile Ala Asp Met 
    50                  55                  60                  


Met Gly Glu Val Lys Leu Thr Lys Leu Ala Glu Phe Tyr Asp Val Tyr 
65                  70                  75                  80  


Leu Lys Phe Arg Lys Asn Pro Lys Asp Asp Glu Leu Gln Lys Gln Leu 
                85                  90                  95      


Lys Asp Leu Gln Ala Val Leu Arg Lys Glu Ile Val Lys Pro Ile Gly 
            100                 105                 110         


Asn Gly Gly Lys Tyr Lys Ala Gly Tyr Asp Arg Leu Phe Gly Ala Lys 
        115                 120                 125             


Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp Leu Ala Lys Phe Val Ile 
    130                 135                 140                 


Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu Ala His Leu Ala His Phe 
145                 150                 155                 160 


Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe His Asp Asn Arg Lys Asn 
                165                 170                 175     


Met Tyr Ser Asp Glu Asp Lys His Thr Ala Ile Ala Tyr Arg Leu Ile 
            180                 185                 190         


His Glu Asn Leu Pro Arg Phe Ile Asp Asn Leu Gln Ile Leu Thr Thr 
        195                 200                 205             


Ile Lys Gln Lys His Ser Ala Leu Tyr Asp Gln Ile Ile Asn Glu Leu 
    210                 215                 220                 


Thr Ala Ser Gly Leu Asp Val Ser Leu Ala Ser His Leu Asp Gly Tyr 
225                 230                 235                 240 


His Lys Leu Leu Thr Gln Glu Gly Ile Thr Ala Tyr Asn Thr Leu Leu 
                245                 250                 255     


Gly Gly Ile Ser Gly Glu Ala Gly Ser Pro Lys Ile Gln Gly Ile Asn 
            260                 265                 270         


Glu Leu Ile Asn Ser His His Asn Gln His Cys His Lys Ser Glu Arg 
        275                 280                 285             


Ile Ala Lys Leu Arg Pro Leu His Lys Gln Ile Leu Ser Asp Gly Met 
    290                 295                 300                 


Ser Val Ser Phe Leu Pro Ser Lys Phe Ala Asp Asp Ser Glu Met Cys 
305                 310                 315                 320 


Gln Ala Val Asn Glu Phe Tyr Arg His Tyr Ala Asp Val Phe Ala Lys 
                325                 330                 335     


Val Gln Ser Leu Phe Asp Gly Phe Asp Asp His Gln Lys Asp Gly Ile 
            340                 345                 350         


Tyr Val Glu His Lys Asn Leu Asn Glu Leu Ser Lys Gln Ala Phe Gly 
        355                 360                 365             


Asp Phe Ala Leu Leu Gly Arg Val Leu Asp Gly Tyr Tyr Val Asp Val 
    370                 375                 380                 


Val Asn Pro Glu Phe Asn Glu Arg Phe Ala Lys Ala Lys Thr Asp Asn 
385                 390                 395                 400 


Ala Lys Ala Lys Leu Thr Lys Glu Lys Asp Lys Phe Ile Lys Gly Val 
                405                 410                 415     


His Ser Leu Ala Ser Leu Glu Gln Ala Ile Glu His Tyr Thr Ala Arg 
            420                 425                 430         


His Asp Asp Glu Ser Val Gln Ala Gly Lys Leu Gly Gln Tyr Phe Lys 
        435                 440                 445             


His Gly Leu Ala Gly Val Asp Asn Pro Ile Gln Lys Ile His Asn Asn 
    450                 455                 460                 


His Ser Thr Ile Lys Gly Phe Leu Glu Arg Glu Arg Pro Ala Gly Glu 
465                 470                 475                 480 


Arg Ala Leu Pro Lys Ile Lys Ser Gly Lys Asn Pro Glu Met Thr Gln 
                485                 490                 495     


Leu Arg Gln Leu Lys Glu Leu Leu Asp Asn Ala Leu Asn Val Ala His 
            500                 505                 510         


Phe Ala Lys Leu Leu Thr Thr Lys Thr Thr Leu Asp Asn Gln Asp Gly 
        515                 520                 525             


Asn Phe Tyr Gly Glu Phe Gly Val Leu Tyr Asp Glu Leu Ala Lys Ile 
    530                 535                 540                 


Pro Thr Leu Tyr Asn Lys Val Arg Asp Tyr Leu Ser Gln Lys Pro Phe 
545                 550                 555                 560 


Ser Thr Glu Lys Tyr Lys Leu Asn Phe Gly Asn Pro Thr Leu Leu Asn 
                565                 570                 575     


Gly Trp Asp Leu Asn Lys Glu Lys Asp Asn Phe Gly Val Ile Leu Gln 
            580                 585                 590         


Lys Asp Gly Cys Tyr Tyr Leu Ala Leu Leu Asp Lys Ala His Lys Lys 
        595                 600                 605             


Val Phe Asp Asn Ala Pro Asn Thr Gly Lys Ser Ile Tyr Gln Lys Met 
    610                 615                 620                 


Ile Tyr Lys Tyr Leu Glu Val Arg Lys Gln Phe Pro Lys Val Phe Phe 
625                 630                 635                 640 


Ser Lys Glu Ala Ile Ala Ile Asn Tyr His Pro Ser Lys Glu Leu Val 
                645                 650                 655     


Glu Ile Lys Asp Lys Gly Arg Gln Arg Ser Asp Asp Glu Arg Leu Lys 
            660                 665                 670         


Leu Tyr Arg Phe Ile Leu Glu Cys Leu Lys Ile His Pro Lys Tyr Asp 
        675                 680                 685             


Lys Lys Phe Glu Gly Ala Ile Gly Asp Ile Gln Leu Phe Lys Lys Asp 
    690                 695                 700                 


Lys Lys Gly Arg Glu Val Pro Ile Ser Glu Lys Asp Leu Phe Asp Lys 
705                 710                 715                 720 


Ile Asn Gly Ile Phe Ser Ser Lys Pro Lys Leu Glu Met Glu Asp Phe 
                725                 730                 735     


Phe Ile Gly Glu Phe Lys Arg Tyr Asn Pro Ser Gln Asp Leu Val Asp 
            740                 745                 750         


Gln Tyr Asn Ile Tyr Lys Lys Ile Asp Ser Asn Asp Asn Arg Lys Lys 
        755                 760                 765             


Glu Asn Phe Tyr Asn Asn His Pro Lys Phe Lys Lys Asp Leu Val Arg 
    770                 775                 780                 


Tyr Tyr Tyr Glu Ser Met Cys Lys His Glu Glu Trp Glu Glu Ser Phe 
785                 790                 795                 800 


Glu Phe Ser Lys Lys Leu Gln Asp Ile Gly Cys Tyr Val Asp Val Asn 
                805                 810                 815     


Glu Leu Phe Thr Glu Ile Glu Thr Arg Arg Leu Asn Tyr Lys Ile Ser 
            820                 825                 830         


Phe Cys Asn Ile Asn Ala Asp Tyr Ile Asp Glu Leu Val Glu Gln Gly 
        835                 840                 845             


Gln Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Lys Ala 
    850                 855                 860                 


His Gly Lys Pro Asn Leu His Thr Leu Tyr Phe Lys Ala Leu Phe Ser 
865                 870                 875                 880 


Glu Asp Asn Leu Ala Asp Pro Ile Tyr Lys Leu Asn Gly Glu Ala Gln 
                885                 890                 895     


Ile Phe Tyr Arg Lys Ala Ser Leu Asp Met Asn Glu Thr Thr Ile His 
            900                 905                 910         


Arg Ala Gly Glu Val Leu Glu Asn Lys Asn Pro Asp Asn Pro Lys Lys 
        915                 920                 925             


Arg Gln Phe Val Tyr Asp Ile Ile Lys Asp Lys Arg Tyr Thr Gln Asp 
    930                 935                 940                 


Lys Phe Met Leu His Val Pro Ile Thr Met Asn Phe Gly Val Gln Gly 
945                 950                 955                 960 


Met Thr Ile Lys Glu Phe Asn Lys Lys Val Asn Gln Ser Ile Gln Gln 
                965                 970                 975     


Tyr Asp Glu Val Asn Val Ile Gly Ile Asp Arg Gly Glu Arg His Leu 
            980                 985                 990         


Leu Tyr Leu Thr Val Ile Asn Ser  Lys Gly Glu Ile Leu  Glu Gln Cys 
        995                 1000                 1005             


Ser Leu  Asn Asp Ile Thr Thr  Ala Ser Ala Asn Gly  Thr Gln Met 
    1010                 1015                 1020             


Thr Thr  Pro Tyr His Lys Ile  Leu Asp Lys Arg Glu  Ile Glu Arg 
    1025                 1030                 1035             


Leu Asn  Ala Arg Val Gly Trp  Gly Glu Ile Glu Thr  Ile Lys Glu 
    1040                 1045                 1050             


Leu Lys  Ser Gly Tyr Leu Ser  His Val Val His Gln  Ile Ser Gln 
    1055                 1060                 1065             


Leu Met  Leu Lys Tyr Asn Ala  Ile Val Val Leu Glu  Asp Leu Asn 
    1070                 1075                 1080             


Phe Gly  Phe Lys Arg Gly Arg  Phe Lys Val Glu Lys  Gln Ile Tyr 
    1085                 1090                 1095             


Gln Asn  Phe Glu Asn Ala Leu  Ile Lys Lys Leu Asn  His Leu Val 
    1100                 1105                 1110             


Leu Lys  Asp Lys Ala Asp Asp  Glu Ile Gly Ser Tyr  Lys Asn Ala 
    1115                 1120                 1125             


Leu Gln  Leu Thr Asn Asn Phe  Thr Asp Leu Lys Ser  Ile Gly Lys 
    1130                 1135                 1140             


Gln Thr  Gly Phe Leu Phe Tyr  Val Pro Ala Trp Asn  Thr Ser Lys 
    1145                 1150                 1155             


Ile Asp  Pro Glu Thr Gly Phe  Val Asp Leu Leu Lys  Pro Arg Tyr 
    1160                 1165                 1170             


Glu Asn  Ile Ala Gln Ser Gln  Ala Phe Phe Gly Lys  Phe Asp Lys 
    1175                 1180                 1185             


Ile Cys  Tyr Asn Ala Asp Lys  Asp Tyr Phe Glu Phe  His Ile Asp 
    1190                 1195                 1200             


Tyr Ala  Lys Phe Thr Asp Lys  Ala Lys Asn Ser Arg  Gln Ile Trp 
    1205                 1210                 1215             


Thr Ile  Cys Ser His Gly Asp  Lys Arg Tyr Val Tyr  Asp Lys Thr 
    1220                 1225                 1230             


Ala Asn  Gln Asn Lys Gly Ala  Ala Lys Gly Ile Asn  Val Asn Asp 
    1235                 1240                 1245             


Glu Leu  Lys Ser Leu Phe Ala  Arg His His Ile Asn  Glu Lys Gln 
    1250                 1255                 1260             


Pro Asn  Leu Val Met Asp Ile  Cys Gln Asn Asn Asp  Lys Glu Phe 
    1265                 1270                 1275             


His Lys  Ser Leu Met Tyr Leu  Leu Lys Thr Leu Leu  Ala Leu Arg 
    1280                 1285                 1290             


Tyr Ser  Asn Ala Ser Ser Asp  Glu Asp Phe Ile Leu  Ser Pro Val 
    1295                 1300                 1305             


Ala Asn  Asp Glu Gly Val Phe  Phe Asn Ser Ala Leu  Ala Asp Asp 
    1310                 1315                 1320             


Thr Gln  Pro Gln Asn Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala 
    1325                 1330                 1335             


Leu Lys  Gly Leu Trp Leu Leu  Asn Glu Leu Lys Asn  Ser Asp Asp 
    1340                 1345                 1350             


Leu Asn  Lys Val Lys Leu Ala  Ile Asp Asn Gln Thr  Trp Leu Asn 
    1355                 1360                 1365             


Phe Ala  Gln Asn Arg 
    1370             


<210> 6
<211> 1259
<212> PRT
<213> Moraxella bovoculi

<400> 6
Met Gly Ile His Gly Val Pro Ala Ala Leu Phe Gln Asp Phe Thr His 
1               5                   10                  15      


Leu Tyr Pro Leu Ser Lys Thr Val Arg Phe Glu Leu Lys Pro Ile Gly 
            20                  25                  30          


Arg Thr Leu Glu His Ile His Ala Lys Asn Phe Leu Ser Gln Asp Glu 
        35                  40                  45              


Thr Met Ala Asp Met Tyr Gln Lys Val Lys Val Ile Leu Asp Asp Tyr 
    50                  55                  60                  


His Arg Asp Phe Ile Ala Asp Met Met Gly Glu Val Lys Leu Thr Lys 
65                  70                  75                  80  


Leu Ala Glu Phe Tyr Asp Val Tyr Leu Lys Phe Arg Lys Asn Pro Lys 
                85                  90                  95      


Asp Asp Gly Leu Gln Lys Gln Leu Lys Asp Leu Gln Ala Val Leu Arg 
            100                 105                 110         


Lys Glu Ser Val Lys Pro Ile Gly Ser Gly Gly Lys Tyr Lys Thr Gly 
        115                 120                 125             


Tyr Asp Arg Leu Phe Gly Ala Lys Leu Phe Lys Asp Gly Lys Glu Leu 
    130                 135                 140                 


Gly Asp Leu Ala Lys Phe Val Ile Ala Gln Glu Gly Glu Ser Ser Pro 
145                 150                 155                 160 


Lys Leu Ala His Leu Ala His Phe Glu Lys Phe Ser Thr Tyr Phe Thr 
                165                 170                 175     


Gly Phe His Asp Asn Arg Lys Asn Met Tyr Ser Asp Glu Asp Lys His 
            180                 185                 190         


Thr Ala Ile Ala Tyr Arg Leu Ile His Glu Asn Leu Pro Arg Phe Ile 
        195                 200                 205             


Asp Asn Leu Gln Ile Leu Thr Thr Ile Lys Gln Lys His Ser Ala Leu 
    210                 215                 220                 


Tyr Asp Gln Ile Ile Asn Glu Leu Thr Ala Ser Gly Leu Asp Val Ser 
225                 230                 235                 240 


Leu Ala Ser His Leu Asp Gly Tyr His Lys Leu Leu Thr Gln Glu Gly 
                245                 250                 255     


Ile Thr Ala Tyr Asn Arg Ile Ile Gly Glu Val Asn Gly Tyr Thr Asn 
            260                 265                 270         


Lys His Asn Gln Ile Cys His Lys Ser Glu Arg Ile Ala Lys Leu Arg 
        275                 280                 285             


Pro Leu His Lys Gln Ile Leu Ser Asp Gly Met Gly Val Ser Phe Leu 
    290                 295                 300                 


Pro Ser Lys Phe Ala Asp Asp Ser Glu Met Cys Gln Ala Val Asn Glu 
305                 310                 315                 320 


Phe Tyr Arg His Tyr Thr Asp Val Phe Ala Lys Val Gln Ser Leu Phe 
                325                 330                 335     


Asp Gly Phe Asp Asp His Gln Lys Asp Gly Ile Tyr Val Glu His Lys 
            340                 345                 350         


Asn Leu Asn Glu Leu Ser Lys Gln Ala Phe Gly Asp Phe Ala Leu Leu 
        355                 360                 365             


Gly Arg Val Leu Asp Gly Tyr Tyr Val Asp Val Val Asn Pro Glu Phe 
    370                 375                 380                 


Asn Glu Arg Phe Ala Lys Ala Lys Thr Asp Asn Ala Lys Ala Lys Leu 
385                 390                 395                 400 


Thr Lys Glu Lys Asp Lys Phe Ile Lys Gly Val His Ser Leu Ala Ser 
                405                 410                 415     


Leu Glu Gln Ala Ile Glu His His Thr Ala Arg His Asp Asp Glu Ser 
            420                 425                 430         


Val Gln Ala Gly Lys Leu Gly Gln Tyr Phe Lys His Gly Leu Ala Gly 
        435                 440                 445             


Val Asp Asn Pro Ile Gln Lys Ile His Asn Asn His Ser Thr Ile Lys 
    450                 455                 460                 


Gly Phe Leu Glu Arg Glu Arg Pro Ala Gly Glu Arg Ala Leu Pro Lys 
465                 470                 475                 480 


Ile Lys Ser Gly Lys Asn Pro Glu Met Thr Gln Leu Arg Gln Leu Lys 
                485                 490                 495     


Glu Leu Leu Asp Asn Ala Leu Asn Val Ala His Phe Ala Lys Leu Leu 
            500                 505                 510         


Thr Thr Lys Thr Thr Leu Asp Asn Gln Asp Gly Asn Phe Tyr Gly Glu 
        515                 520                 525             


Phe Gly Val Leu Tyr Asp Glu Leu Ala Lys Ile Pro Thr Leu Tyr Asn 
    530                 535                 540                 


Lys Val Arg Asp Tyr Leu Ser Gln Lys Pro Phe Ser Thr Glu Lys Tyr 
545                 550                 555                 560 


Lys Leu Asn Phe Gly Asn Pro Thr Leu Leu Asn Gly Trp Asp Leu Asn 
                565                 570                 575     


Lys Glu Lys Asp Asn Phe Gly Val Ile Leu Gln Lys Asp Gly Cys Tyr 
            580                 585                 590         


Tyr Leu Ala Leu Leu Asp Lys Ala His Lys Lys Val Phe Asp Asn Ala 
        595                 600                 605             


Pro Asn Thr Gly Lys Asn Val Tyr Gln Lys Met Val Tyr Lys Leu Leu 
    610                 615                 620                 


Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ala Lys Ser Asn 
625                 630                 635                 640 


Leu Asp Tyr Tyr Asn Pro Ser Ala Glu Leu Leu Asp Lys Tyr Ala Lys 
                645                 650                 655     


Gly Thr His Lys Lys Gly Asp Asn Phe Asn Leu Lys Asp Cys His Ala 
            660                 665                 670         


Leu Ile Asp Phe Phe Lys Ala Gly Ile Asn Lys His Pro Glu Trp Gln 
        675                 680                 685             


His Phe Gly Phe Lys Phe Ser Pro Thr Ser Ser Tyr Arg Asp Leu Ser 
    690                 695                 700                 


Asp Phe Tyr Arg Glu Val Glu Pro Gln Gly Tyr Gln Val Lys Phe Val 
705                 710                 715                 720 


Asp Ile Asn Ala Asp Tyr Ile Asp Glu Leu Val Glu Gln Gly Lys Leu 
                725                 730                 735     


Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Lys Ala His Gly 
            740                 745                 750         


Lys Pro Asn Leu His Thr Leu Tyr Phe Lys Ala Leu Phe Ser Glu Asp 
        755                 760                 765             


Asn Leu Ala Asp Pro Ile Tyr Lys Leu Asn Gly Glu Ala Gln Ile Phe 
    770                 775                 780                 


Tyr Arg Lys Ala Ser Leu Asp Met Asn Glu Thr Thr Ile His Arg Ala 
785                 790                 795                 800 


Gly Glu Val Leu Glu Asn Lys Asn Pro Asp Asn Pro Lys Lys Arg Gln 
                805                 810                 815     


Phe Val Tyr Asp Ile Ile Lys Asp Lys Arg Tyr Thr Gln Asp Lys Phe 
            820                 825                 830         


Met Leu His Val Pro Ile Thr Met Asn Phe Gly Val Gln Gly Met Thr 
        835                 840                 845             


Ile Lys Glu Phe Asn Lys Lys Val Asn Gln Ser Ile Gln Gln Tyr Asp 
    850                 855                 860                 


Glu Val Asn Val Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr 
865                 870                 875                 880 


Leu Thr Val Ile Asn Ser Lys Gly Glu Ile Leu Glu Gln Arg Ser Leu 
                885                 890                 895     


Asn Asp Ile Thr Thr Ala Ser Ala Asn Gly Thr Gln Val Thr Thr Pro 
            900                 905                 910         


Tyr His Lys Ile Leu Asp Lys Arg Glu Ile Glu Arg Leu Asn Ala Arg 
        915                 920                 925             


Val Gly Trp Gly Glu Ile Glu Thr Ile Lys Glu Leu Lys Ser Gly Tyr 
    930                 935                 940                 


Leu Ser His Val Val His Gln Ile Asn Gln Leu Met Leu Lys Tyr Asn 
945                 950                 955                 960 


Ala Ile Val Val Leu Glu Asp Leu Asn Phe Gly Phe Lys Arg Gly Arg 
                965                 970                 975     


Phe Lys Val Glu Lys Gln Ile Tyr Gln Asn Phe Glu Asn Ala Leu Ile 
            980                 985                 990         


Lys Lys Leu Asn His Leu Val Leu  Lys Asp Lys Ala Asp  Asp Glu Ile 
        995                 1000                 1005             


Gly Ser  Tyr Lys Asn Ala Leu  Gln Leu Thr Asn Asn  Phe Thr Asp 
    1010                 1015                 1020             


Leu Lys  Ser Ile Gly Lys Gln  Thr Gly Phe Leu Phe  Tyr Val Pro 
    1025                 1030                 1035             


Ala Trp  Asn Thr Ser Lys Ile  Asp Pro Glu Thr Gly  Phe Val Asp 
    1040                 1045                 1050             


Leu Leu  Lys Pro Arg Tyr Glu  Asn Ile Ala Gln Ser  Gln Ala Phe 
    1055                 1060                 1065             


Phe Gly  Lys Phe Asp Lys Ile  Cys Tyr Asn Thr Asp  Lys Gly Tyr 
    1070                 1075                 1080             


Phe Glu  Phe His Ile Asp Tyr  Ala Lys Phe Thr Asp  Lys Ala Lys 
    1085                 1090                 1095             


Asn Ser  Arg Gln Lys Trp Ala  Ile Cys Ser His Gly  Asp Lys Arg 
    1100                 1105                 1110             


Tyr Val  Tyr Asp Lys Thr Ala  Asn Gln Asn Lys Gly  Ala Ala Lys 
    1115                 1120                 1125             


Gly Ile  Asn Val Asn Asp Glu  Leu Lys Ser Leu Phe  Ala Arg Tyr 
    1130                 1135                 1140             


His Ile  Asn Asp Lys Gln Pro  Asn Leu Val Met Asp  Ile Cys Gln 
    1145                 1150                 1155             


Asn Asn  Asp Lys Glu Phe His  Lys Ser Leu Met Cys  Leu Leu Lys 
    1160                 1165                 1170             


Thr Leu  Leu Ala Leu Arg Tyr  Ser Asn Ala Ser Ser  Asp Glu Asp 
    1175                 1180                 1185             


Phe Ile  Leu Ser Pro Val Ala  Asn Asp Glu Gly Val  Phe Phe Asn 
    1190                 1195                 1200             


Ser Ala  Leu Ala Asp Asp Thr  Gln Pro Gln Asn Ala  Asp Ala Asn 
    1205                 1210                 1215             


Gly Ala  Tyr His Ile Ala Leu  Lys Gly Leu Trp Leu  Leu Asn Glu 
    1220                 1225                 1230             


Leu Lys  Asn Ser Asp Asp Leu  Asn Lys Val Lys Leu  Ala Ile Asp 
    1235                 1240                 1245             


Asn Gln  Thr Trp Leu Asn Phe  Ala Gln Asn Arg 
    1250                 1255                 


<210> 7
<211> 1269
<212> PRT
<213> Moraxella bovoculi

<400> 7
Met Gly Ile His Gly Val Pro Ala Ala Leu Phe Gln Asp Phe Thr His 
1               5                   10                  15      


Leu Tyr Pro Leu Ser Lys Thr Val Arg Phe Glu Leu Lys Pro Ile Gly 
            20                  25                  30          


Lys Thr Leu Glu His Ile His Ala Lys Asn Phe Leu Asn Gln Asp Glu 
        35                  40                  45              


Thr Met Ala Asp Met Tyr Gln Lys Val Lys Ala Ile Leu Asp Asp Tyr 
    50                  55                  60                  


His Arg Asp Phe Ile Ala Asp Met Met Gly Glu Val Lys Leu Thr Lys 
65                  70                  75                  80  


Leu Ala Glu Phe Tyr Asp Val Tyr Leu Lys Phe Arg Lys Asn Pro Lys 
                85                  90                  95      


Asp Asp Gly Leu Gln Lys Gln Leu Lys Asp Leu Gln Ala Val Leu Arg 
            100                 105                 110         


Lys Glu Ile Val Lys Pro Ile Gly Asn Gly Gly Lys Tyr Lys Ala Gly 
        115                 120                 125             


Tyr Asp Arg Leu Phe Gly Ala Lys Leu Phe Lys Asp Gly Lys Glu Leu 
    130                 135                 140                 


Gly Asp Leu Ala Lys Phe Val Ile Ala Gln Glu Gly Glu Ser Ser Pro 
145                 150                 155                 160 


Lys Leu Ala His Leu Ala His Phe Glu Lys Phe Ser Thr Tyr Phe Thr 
                165                 170                 175     


Gly Phe His Asp Asn Arg Lys Asn Met Tyr Ser Asp Glu Asp Lys His 
            180                 185                 190         


Thr Ala Ile Ala Tyr Arg Leu Ile His Glu Asn Leu Pro Arg Phe Ile 
        195                 200                 205             


Asp Asn Leu Gln Ile Leu Ala Thr Ile Lys Gln Lys His Ser Ala Leu 
    210                 215                 220                 


Tyr Asp Gln Ile Ile Asn Glu Leu Thr Ala Ser Gly Leu Asp Val Ser 
225                 230                 235                 240 


Leu Ala Ser His Leu Asp Gly Tyr His Lys Leu Leu Thr Gln Glu Gly 
                245                 250                 255     


Ile Thr Ala Tyr Asn Thr Leu Leu Gly Gly Ile Ser Gly Glu Ala Gly 
            260                 265                 270         


Ser Arg Lys Ile Gln Gly Ile Asn Glu Leu Ile Asn Ser His His Asn 
        275                 280                 285             


Gln His Cys His Lys Ser Glu Arg Ile Ala Lys Leu Arg Pro Leu His 
    290                 295                 300                 


Lys Gln Ile Leu Ser Asp Gly Met Gly Val Ser Phe Leu Pro Ser Lys 
305                 310                 315                 320 


Phe Ala Asp Asp Ser Glu Val Cys Gln Ala Val Asn Glu Phe Tyr Arg 
                325                 330                 335     


His Tyr Ala Asp Val Phe Ala Lys Val Gln Ser Leu Phe Asp Gly Phe 
            340                 345                 350         


Asp Asp Tyr Gln Lys Asp Gly Ile Tyr Val Glu Tyr Lys Asn Leu Asn 
        355                 360                 365             


Glu Leu Ser Lys Gln Ala Phe Gly Asp Phe Ala Leu Leu Gly Arg Val 
    370                 375                 380                 


Leu Asp Gly Tyr Tyr Val Asp Val Val Asn Pro Glu Phe Asn Glu Arg 
385                 390                 395                 400 


Phe Ala Lys Ala Lys Thr Asp Asn Ala Lys Ala Lys Leu Thr Lys Glu 
                405                 410                 415     


Lys Asp Lys Phe Ile Lys Gly Val His Ser Leu Ala Ser Leu Glu Gln 
            420                 425                 430         


Ala Ile Glu His Tyr Thr Ala Arg His Asp Asp Glu Ser Val Gln Ala 
        435                 440                 445             


Gly Lys Leu Gly Gln Tyr Phe Lys His Gly Leu Ala Gly Val Asp Asn 
    450                 455                 460                 


Pro Ile Gln Lys Ile His Asn Asn His Ser Thr Ile Lys Gly Phe Leu 
465                 470                 475                 480 


Glu Arg Glu Arg Pro Ala Gly Glu Arg Ala Leu Pro Lys Ile Lys Ser 
                485                 490                 495     


Asp Lys Ser Pro Glu Ile Arg Gln Leu Lys Glu Leu Leu Asp Asn Ala 
            500                 505                 510         


Leu Asn Val Ala His Phe Ala Lys Leu Leu Thr Thr Lys Thr Thr Leu 
        515                 520                 525             


His Asn Gln Asp Gly Asn Phe Tyr Gly Glu Phe Gly Ala Leu Tyr Asp 
    530                 535                 540                 


Glu Leu Ala Lys Ile Ala Thr Leu Tyr Asn Lys Val Arg Asp Tyr Leu 
545                 550                 555                 560 


Ser Gln Lys Pro Phe Ser Thr Glu Lys Tyr Lys Leu Asn Phe Gly Asn 
                565                 570                 575     


Pro Thr Leu Leu Asn Gly Trp Asp Leu Asn Lys Glu Lys Asp Asn Phe 
            580                 585                 590         


Gly Val Ile Leu Gln Lys Asp Gly Cys Tyr Tyr Leu Ala Leu Leu Asp 
        595                 600                 605             


Lys Ala His Lys Lys Val Phe Asp Asn Ala Pro Asn Thr Gly Lys Ser 
    610                 615                 620                 


Val Tyr Gln Lys Met Ile Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
625                 630                 635                 640 


Leu Pro Lys Val Phe Phe Ala Lys Ser Asn Leu Asp Tyr Tyr Asn Pro 
                645                 650                 655     


Ser Ala Glu Leu Leu Asp Lys Tyr Ala Gln Gly Thr His Lys Lys Gly 
            660                 665                 670         


Asp Asn Phe Asn Leu Lys Asp Cys His Ala Leu Ile Asp Phe Phe Lys 
        675                 680                 685             


Ala Gly Ile Asn Lys His Pro Glu Trp Gln His Phe Gly Phe Lys Phe 
    690                 695                 700                 


Ser Pro Thr Ser Ser Tyr Gln Asp Leu Ser Asp Phe Tyr Arg Glu Val 
705                 710                 715                 720 


Glu Pro Gln Gly Tyr Gln Val Lys Phe Val Asp Ile Asn Ala Asp Tyr 
                725                 730                 735     


Ile Asn Glu Leu Val Glu Gln Gly Gln Leu Tyr Leu Phe Gln Ile Tyr 
            740                 745                 750         


Asn Lys Asp Phe Ser Pro Lys Ala His Gly Lys Pro Asn Leu His Thr 
        755                 760                 765             


Leu Tyr Phe Lys Ala Leu Phe Ser Glu Asp Asn Leu Val Asn Pro Ile 
    770                 775                 780                 


Tyr Lys Leu Asn Gly Glu Ala Glu Ile Phe Tyr Arg Lys Ala Ser Leu 
785                 790                 795                 800 


Asp Met Asn Glu Thr Thr Ile His Arg Ala Gly Glu Val Leu Glu Asn 
                805                 810                 815     


Lys Asn Pro Asp Asn Pro Lys Lys Arg Gln Phe Val Tyr Asp Ile Ile 
            820                 825                 830         


Lys Asp Lys Arg Tyr Thr Gln Asp Lys Phe Met Leu His Val Pro Ile 
        835                 840                 845             


Thr Met Asn Phe Gly Val Gln Gly Met Thr Ile Lys Glu Phe Asn Lys 
    850                 855                 860                 


Lys Val Asn Gln Ser Ile Gln Gln Tyr Asp Glu Val Asn Val Ile Gly 
865                 870                 875                 880 


Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Thr Val Ile Asn Ser 
                885                 890                 895     


Lys Gly Glu Ile Leu Glu Gln Arg Ser Leu Asn Asp Ile Thr Thr Ala 
            900                 905                 910         


Ser Ala Asn Gly Thr Gln Met Thr Thr Pro Tyr His Lys Ile Leu Asp 
        915                 920                 925             


Lys Arg Glu Ile Glu Arg Leu Asn Ala Arg Val Gly Trp Gly Glu Ile 
    930                 935                 940                 


Glu Thr Ile Lys Glu Leu Lys Ser Gly Tyr Leu Ser His Val Val His 
945                 950                 955                 960 


Gln Ile Ser Gln Leu Met Leu Lys Tyr Asn Ala Ile Val Val Leu Glu 
                965                 970                 975     


Asp Leu Asn Phe Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln 
            980                 985                 990         


Ile Tyr Gln Asn Phe Glu Asn Ala  Leu Ile Lys Lys Leu  Asn His Leu 
        995                 1000                 1005             


Val Leu  Lys Asp Lys Ala Asp  Asp Glu Ile Gly Ser  Tyr Lys Asn 
    1010                 1015                 1020             


Ala Leu  Gln Leu Thr Asn Asn  Phe Thr Asp Leu Lys  Ser Ile Gly 
    1025                 1030                 1035             


Lys Gln  Thr Gly Phe Leu Phe  Tyr Val Pro Ala Trp  Asn Thr Ser 
    1040                 1045                 1050             


Lys Ile  Asp Pro Glu Thr Gly  Phe Val Asp Leu Leu  Lys Pro Arg 
    1055                 1060                 1065             


Tyr Glu  Asn Ile Ala Gln Ser  Gln Ala Phe Phe Gly  Lys Phe Asp 
    1070                 1075                 1080             


Lys Ile  Cys Tyr Asn Ala Asp  Arg Gly Tyr Phe Glu  Phe His Ile 
    1085                 1090                 1095             


Asp Tyr  Ala Lys Phe Asn Asp  Lys Ala Lys Asn Ser  Arg Gln Ile 
    1100                 1105                 1110             


Trp Lys  Ile Cys Ser His Gly  Asp Lys Arg Tyr Val  Tyr Asp Lys 
    1115                 1120                 1125             


Thr Ala  Asn Gln Asn Lys Gly  Ala Thr Ile Gly Val  Asn Val Asn 
    1130                 1135                 1140             


Asp Glu  Leu Lys Ser Leu Phe  Thr Arg Tyr His Ile  Asn Asp Lys 
    1145                 1150                 1155             


Gln Pro  Asn Leu Val Met Asp  Ile Cys Gln Asn Asn  Asp Lys Glu 
    1160                 1165                 1170             


Phe His  Lys Ser Leu Met Tyr  Leu Leu Lys Thr Leu  Leu Ala Leu 
    1175                 1180                 1185             


Arg Tyr  Ser Asn Ala Ser Ser  Asp Glu Asp Phe Ile  Leu Ser Pro 
    1190                 1195                 1200             


Val Ala  Asn Asp Glu Gly Val  Phe Phe Asn Ser Ala  Leu Ala Asp 
    1205                 1210                 1215             


Asp Thr  Gln Pro Gln Asn Ala  Asp Ala Asn Gly Ala  Tyr His Ile 
    1220                 1225                 1230             


Ala Leu  Lys Gly Leu Trp Leu  Leu Asn Glu Leu Lys  Asn Ser Asp 
    1235                 1240                 1245             


Asp Leu  Asn Lys Val Lys Leu  Ala Ile Asp Asn Gln  Thr Trp Leu 
    1250                 1255                 1260             


Asn Phe  Ala Gln Asn Arg 
    1265                 


<210> 8
<211> 1306
<212> PRT
<213> Thiomicrospira sp.

<400> 8
Met Gly Ile His Gly Val Pro Ala Ala Thr Lys Thr Phe Asp Ser Glu 
1               5                   10                  15      


Phe Phe Asn Leu Tyr Ser Leu Gln Lys Thr Val Arg Phe Glu Leu Lys 
            20                  25                  30          


Pro Val Gly Glu Thr Ala Ser Phe Val Glu Asp Phe Lys Asn Glu Gly 
        35                  40                  45              


Leu Lys Arg Val Val Ser Glu Asp Glu Arg Arg Ala Val Asp Tyr Gln 
    50                  55                  60                  


Lys Val Lys Glu Ile Ile Asp Asp Tyr His Arg Asp Phe Ile Glu Glu 
65                  70                  75                  80  


Ser Leu Asn Tyr Phe Pro Glu Gln Val Ser Lys Asp Ala Leu Glu Gln 
                85                  90                  95      


Ala Phe His Leu Tyr Gln Lys Leu Lys Ala Ala Lys Val Glu Glu Arg 
            100                 105                 110         


Glu Lys Ala Leu Lys Glu Trp Glu Ala Leu Gln Lys Lys Leu Arg Glu 
        115                 120                 125             


Lys Val Val Lys Cys Phe Ser Asp Ser Asn Lys Ala Arg Phe Ser Arg 
    130                 135                 140                 


Ile Asp Lys Lys Glu Leu Ile Lys Glu Asp Leu Ile Asn Trp Leu Val 
145                 150                 155                 160 


Ala Gln Asn Arg Glu Asp Asp Ile Pro Thr Val Glu Thr Phe Asn Asn 
                165                 170                 175     


Phe Thr Thr Tyr Phe Thr Gly Phe His Glu Asn Arg Lys Asn Ile Tyr 
            180                 185                 190         


Ser Lys Asp Asp His Ala Thr Ala Ile Ser Phe Arg Leu Ile His Glu 
        195                 200                 205             


Asn Leu Pro Lys Phe Phe Asp Asn Val Ile Ser Phe Asn Lys Leu Lys 
    210                 215                 220                 


Glu Gly Phe Pro Glu Leu Lys Phe Asp Lys Val Lys Glu Asp Leu Glu 
225                 230                 235                 240 


Val Asp Tyr Asp Leu Lys His Ala Phe Glu Ile Glu Tyr Phe Val Asn 
                245                 250                 255     


Phe Val Thr Gln Ala Gly Ile Asp Gln Tyr Asn Tyr Leu Leu Gly Gly 
            260                 265                 270         


Lys Thr Leu Glu Asp Gly Thr Lys Lys Gln Gly Met Asn Glu Gln Ile 
        275                 280                 285             


Asn Leu Phe Lys Gln Gln Gln Thr Arg Asp Lys Ala Arg Gln Ile Pro 
    290                 295                 300                 


Lys Leu Ile Pro Leu Phe Lys Gln Ile Leu Ser Glu Arg Thr Glu Ser 
305                 310                 315                 320 


Gln Ser Phe Ile Pro Lys Gln Phe Glu Ser Asp Gln Glu Leu Phe Asp 
                325                 330                 335     


Ser Leu Gln Lys Leu His Asn Asn Cys Gln Asp Lys Phe Thr Val Leu 
            340                 345                 350         


Gln Gln Ala Ile Leu Gly Leu Ala Glu Ala Asp Leu Lys Lys Val Phe 
        355                 360                 365             


Ile Lys Thr Ser Asp Leu Asn Ala Leu Ser Asn Thr Ile Phe Gly Asn 
    370                 375                 380                 


Tyr Ser Val Phe Ser Asp Ala Leu Asn Leu Tyr Lys Glu Ser Leu Lys 
385                 390                 395                 400 


Thr Lys Lys Ala Gln Glu Ala Phe Glu Lys Leu Pro Ala His Ser Ile 
                405                 410                 415     


His Asp Leu Ile Gln Tyr Leu Glu Gln Phe Asn Ser Ser Leu Asp Ala 
            420                 425                 430         


Glu Lys Gln Gln Ser Thr Asp Thr Val Leu Asn Tyr Phe Ile Lys Thr 
        435                 440                 445             


Asp Glu Leu Tyr Ser Arg Phe Ile Lys Ser Thr Ser Glu Ala Phe Thr 
    450                 455                 460                 


Gln Val Gln Pro Leu Phe Glu Leu Glu Ala Leu Ser Ser Lys Arg Arg 
465                 470                 475                 480 


Pro Pro Glu Ser Glu Asp Glu Gly Ala Lys Gly Gln Glu Gly Phe Glu 
                485                 490                 495     


Gln Ile Lys Arg Ile Lys Ala Tyr Leu Asp Thr Leu Met Glu Ala Val 
            500                 505                 510         


His Phe Ala Lys Pro Leu Tyr Leu Val Lys Gly Arg Lys Met Ile Glu 
        515                 520                 525             


Gly Leu Asp Lys Asp Gln Ser Phe Tyr Glu Ala Phe Glu Met Ala Tyr 
    530                 535                 540                 


Gln Glu Leu Glu Ser Leu Ile Ile Pro Ile Tyr Asn Lys Ala Arg Ser 
545                 550                 555                 560 


Tyr Leu Ser Arg Lys Pro Phe Lys Ala Asp Lys Phe Lys Ile Asn Phe 
                565                 570                 575     


Asp Asn Asn Thr Leu Leu Ser Gly Trp Asp Ala Asn Lys Glu Thr Ala 
            580                 585                 590         


Asn Ala Ser Ile Leu Phe Lys Lys Asp Gly Leu Tyr Tyr Leu Gly Ile 
        595                 600                 605             


Met Pro Lys Gly Lys Thr Phe Leu Phe Asp Tyr Phe Val Ser Ser Glu 
    610                 615                 620                 


Asp Ser Glu Lys Leu Lys Gln Arg Arg Gln Lys Thr Ala Glu Glu Ala 
625                 630                 635                 640 


Leu Ala Gln Asp Gly Glu Ser Tyr Phe Glu Lys Ile Arg Tyr Lys Leu 
                645                 650                 655     


Leu Pro Gly Ala Ser Lys Met Leu Pro Lys Val Phe Phe Ser Asn Lys 
            660                 665                 670         


Asn Ile Gly Phe Tyr Asn Pro Ser Asp Asp Ile Leu Arg Ile Arg Asn 
        675                 680                 685             


Thr Ala Ser His Thr Lys Asn Gly Thr Pro Gln Lys Gly His Ser Lys 
    690                 695                 700                 


Val Glu Phe Asn Leu Asn Asp Cys His Lys Met Ile Asp Phe Phe Lys 
705                 710                 715                 720 


Ser Ser Ile Gln Lys His Pro Glu Trp Gly Ser Phe Gly Phe Thr Phe 
                725                 730                 735     


Ser Asp Thr Ser Asp Phe Glu Asp Met Ser Ala Phe Tyr Arg Glu Val 
            740                 745                 750         


Glu Asn Gln Gly Tyr Val Ile Ser Phe Asp Lys Ile Lys Glu Thr Tyr 
        755                 760                 765             


Ile Gln Ser Gln Val Glu Gln Gly Asn Leu Tyr Leu Phe Gln Ile Tyr 
    770                 775                 780                 


Asn Lys Asp Phe Ser Pro Tyr Ser Lys Gly Lys Pro Asn Leu His Thr 
785                 790                 795                 800 


Leu Tyr Trp Lys Ala Leu Phe Glu Glu Ala Asn Leu Asn Asn Val Val 
                805                 810                 815     


Ala Lys Leu Asn Gly Glu Ala Glu Ile Phe Phe Arg Arg His Ser Ile 
            820                 825                 830         


Lys Ala Ser Asp Lys Val Val His Pro Ala Asn Gln Ala Ile Asp Asn 
        835                 840                 845             


Lys Asn Pro His Thr Glu Lys Thr Gln Ser Thr Phe Glu Tyr Asp Leu 
    850                 855                 860                 


Val Lys Asp Lys Arg Tyr Thr Gln Asp Lys Phe Phe Phe His Val Pro 
865                 870                 875                 880 


Ile Ser Leu Asn Phe Lys Ala Gln Gly Val Ser Lys Phe Asn Asp Lys 
                885                 890                 895     


Val Asn Gly Phe Leu Lys Gly Asn Pro Asp Val Asn Ile Ile Gly Ile 
            900                 905                 910         


Asp Arg Gly Glu Arg His Leu Leu Tyr Phe Thr Val Val Asn Gln Lys 
        915                 920                 925             


Gly Glu Ile Leu Val Gln Glu Ser Leu Asn Thr Leu Met Ser Asp Lys 
    930                 935                 940                 


Gly His Val Asn Asp Tyr Gln Gln Lys Leu Asp Lys Lys Glu Gln Glu 
945                 950                 955                 960 


Arg Asp Ala Ala Arg Lys Ser Trp Thr Thr Val Glu Asn Ile Lys Glu 
                965                 970                 975     


Leu Lys Glu Gly Tyr Leu Ser His Val Val His Lys Leu Ala His Leu 
            980                 985                 990         


Ile Ile Lys Tyr Asn Ala Ile Val  Cys Leu Glu Asp Leu  Asn Phe Gly 
        995                 1000                 1005             


Phe Lys  Arg Gly Arg Phe Lys  Val Glu Lys Gln Val  Tyr Gln Lys 
    1010                 1015                 1020             


Phe Glu  Lys Ala Leu Ile Asp  Lys Leu Asn Tyr Leu  Val Phe Lys 
    1025                 1030                 1035             


Glu Lys  Glu Leu Gly Glu Val  Gly His Tyr Leu Thr  Ala Tyr Gln 
    1040                 1045                 1050             


Leu Thr  Ala Pro Phe Glu Ser  Phe Lys Lys Leu Gly  Lys Gln Ser 
    1055                 1060                 1065             


Gly Ile  Leu Phe Tyr Val Pro  Ala Asp Tyr Thr Ser  Lys Ile Asp 
    1070                 1075                 1080             


Pro Thr  Thr Gly Phe Val Asn  Phe Leu Asp Leu Arg  Tyr Gln Ser 
    1085                 1090                 1095             


Val Glu  Lys Ala Lys Gln Leu  Leu Ser Asp Phe Asn  Ala Ile Arg 
    1100                 1105                 1110             


Phe Asn  Ser Val Gln Asn Tyr  Phe Glu Phe Glu Ile  Asp Tyr Lys 
    1115                 1120                 1125             


Lys Leu  Thr Pro Lys Arg Lys  Val Gly Thr Gln Ser  Lys Trp Val 
    1130                 1135                 1140             


Ile Cys  Thr Tyr Gly Asp Val  Arg Tyr Gln Asn Arg  Arg Asn Gln 
    1145                 1150                 1155             


Lys Gly  His Trp Glu Thr Glu  Glu Val Asn Val Thr  Glu Lys Leu 
    1160                 1165                 1170             


Lys Ala  Leu Phe Ala Ser Asp  Ser Lys Thr Thr Thr  Val Ile Asp 
    1175                 1180                 1185             


Tyr Ala  Asn Asp Asp Asn Leu  Ile Asp Val Ile Leu  Glu Gln Asp 
    1190                 1195                 1200             


Lys Ala  Ser Phe Phe Lys Glu  Leu Leu Trp Leu Leu  Lys Leu Thr 
    1205                 1210                 1215             


Met Thr  Leu Arg His Ser Lys  Ile Lys Ser Glu Asp  Asp Phe Ile 
    1220                 1225                 1230             


Leu Ser  Pro Val Lys Asn Glu  Gln Gly Glu Phe Tyr  Asp Ser Arg 
    1235                 1240                 1245             


Lys Ala  Gly Glu Val Trp Pro  Lys Asp Ala Asp Ala  Asn Gly Ala 
    1250                 1255                 1260             


Tyr His  Ile Ala Leu Lys Gly  Leu Trp Asn Leu Gln  Gln Ile Asn 
    1265                 1270                 1275             


Gln Trp  Glu Lys Gly Lys Thr  Leu Asn Leu Ala Ile  Lys Asn Gln 
    1280                 1285                 1290             


Asp Trp  Phe Ser Phe Ile Gln  Glu Lys Pro Tyr Gln  Glu 
    1295                 1300                 1305     


<210> 9
<211> 1214
<212> PRT
<213> Butyrivibrio sp.

<400> 9
Met Gly Ile His Gly Val Pro Ala Ala Tyr Tyr Gln Asn Leu Thr Lys 
1               5                   10                  15      


Lys Tyr Pro Val Ser Lys Thr Ile Arg Asn Glu Leu Ile Pro Ile Gly 
            20                  25                  30          


Lys Thr Leu Glu Asn Ile Arg Lys Asn Asn Ile Leu Glu Ser Asp Val 
        35                  40                  45              


Lys Arg Lys Gln Asp Tyr Glu His Val Lys Gly Ile Met Asp Glu Tyr 
    50                  55                  60                  


His Lys Gln Leu Ile Asn Glu Ala Leu Asp Asn Tyr Met Leu Pro Ser 
65                  70                  75                  80  


Leu Asn Gln Ala Ala Glu Ile Tyr Leu Lys Lys His Val Asp Val Glu 
                85                  90                  95      


Asp Arg Glu Glu Phe Lys Lys Thr Gln Asp Leu Leu Arg Arg Glu Val 
            100                 105                 110         


Thr Gly Arg Leu Lys Glu His Glu Asn Tyr Thr Lys Ile Gly Lys Lys 
        115                 120                 125             


Asp Ile Leu Asp Leu Leu Glu Lys Leu Pro Ser Ile Ser Glu Glu Asp 
    130                 135                 140                 


Tyr Asn Ala Leu Glu Ser Phe Arg Asn Phe Tyr Thr Tyr Phe Thr Ser 
145                 150                 155                 160 


Tyr Asn Lys Val Arg Glu Asn Leu Tyr Ser Asp Glu Glu Lys Ser Ser 
                165                 170                 175     


Thr Val Ala Tyr Arg Leu Ile Asn Glu Asn Leu Pro Lys Phe Leu Asp 
            180                 185                 190         


Asn Ile Lys Ser Tyr Ala Phe Val Lys Ala Ala Gly Val Leu Ala Asp 
        195                 200                 205             


Cys Ile Glu Glu Glu Glu Gln Asp Ala Leu Phe Met Val Glu Thr Phe 
    210                 215                 220                 


Asn Met Thr Leu Thr Gln Glu Gly Ile Asp Met Tyr Asn Tyr Gln Ile 
225                 230                 235                 240 


Gly Lys Val Asn Ser Ala Ile Asn Leu Tyr Asn Gln Lys Asn His Lys 
                245                 250                 255     


Val Glu Glu Phe Lys Lys Ile Pro Lys Met Lys Val Leu Tyr Lys Gln 
            260                 265                 270         


Ile Leu Ser Asp Arg Glu Glu Val Phe Ile Gly Glu Phe Lys Asp Asp 
        275                 280                 285             


Glu Thr Leu Leu Ser Ser Ile Gly Ala Tyr Gly Asn Val Leu Met Thr 
    290                 295                 300                 


Tyr Leu Lys Ser Glu Lys Ile Asn Ile Phe Phe Asp Ala Leu Arg Glu 
305                 310                 315                 320 


Ser Glu Gly Lys Asn Val Tyr Val Lys Asn Asp Leu Ser Lys Thr Thr 
                325                 330                 335     


Met Ser Asn Ile Val Phe Gly Ser Trp Ser Ala Phe Asp Glu Leu Leu 
            340                 345                 350         


Asn Gln Glu Tyr Asp Leu Ala Asn Glu Asn Lys Lys Lys Asp Asp Lys 
        355                 360                 365             


Tyr Phe Glu Lys Arg Gln Lys Glu Leu Lys Lys Asn Lys Ser Tyr Thr 
    370                 375                 380                 


Leu Glu Gln Met Ser Asn Leu Ser Lys Glu Asp Ile Ser Pro Ile Glu 
385                 390                 395                 400 


Asn Tyr Ile Glu Arg Ile Ser Glu Asp Ile Glu Lys Ile Cys Ile Tyr 
                405                 410                 415     


Asn Gly Glu Phe Glu Lys Ile Val Val Asn Glu His Asp Ser Ser Arg 
            420                 425                 430         


Lys Leu Ser Lys Asn Ile Lys Ala Val Lys Val Ile Lys Asp Tyr Leu 
        435                 440                 445             


Asp Ser Ile Lys Glu Leu Glu His Asp Ile Lys Leu Ile Asn Gly Ser 
    450                 455                 460                 


Gly Gln Glu Leu Glu Lys Asn Leu Val Val Tyr Val Gly Gln Glu Glu 
465                 470                 475                 480 


Ala Leu Glu Gln Leu Arg Pro Val Asp Ser Leu Tyr Asn Leu Thr Arg 
                485                 490                 495     


Asn Tyr Leu Thr Lys Lys Pro Phe Ser Thr Glu Lys Val Lys Leu Asn 
            500                 505                 510         


Phe Asn Lys Ser Thr Leu Leu Asn Gly Trp Asp Lys Asn Lys Glu Thr 
        515                 520                 525             


Asp Asn Leu Gly Ile Leu Phe Phe Lys Asp Gly Lys Tyr Tyr Leu Gly 
    530                 535                 540                 


Ile Met Asn Thr Thr Ala Asn Lys Ala Phe Val Asn Pro Pro Ala Ala 
545                 550                 555                 560 


Lys Thr Glu Asn Val Phe Lys Lys Val Asp Tyr Lys Leu Leu Pro Gly 
                565                 570                 575     


Ser Asn Lys Met Leu Pro Lys Val Phe Phe Ala Lys Ser Asn Ile Gly 
            580                 585                 590         


Tyr Tyr Asn Pro Ser Thr Glu Leu Tyr Ser Asn Tyr Lys Lys Gly Thr 
        595                 600                 605             


His Lys Lys Gly Pro Ser Phe Ser Ile Asp Asp Cys His Asn Leu Ile 
    610                 615                 620                 


Asp Phe Phe Lys Glu Ser Ile Lys Lys His Glu Asp Trp Ser Lys Phe 
625                 630                 635                 640 


Gly Phe Glu Phe Ser Asp Thr Ala Asp Tyr Arg Asp Ile Ser Glu Phe 
                645                 650                 655     


Tyr Arg Glu Val Glu Lys Gln Gly Tyr Lys Leu Thr Phe Thr Asp Ile 
            660                 665                 670         


Asp Glu Ser Tyr Ile Asn Asp Leu Ile Glu Lys Asn Glu Leu Tyr Leu 
        675                 680                 685             


Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Tyr Ser Lys Gly Lys Leu 
    690                 695                 700                 


Asn Leu His Thr Leu Tyr Phe Met Met Leu Phe Asp Gln Arg Asn Leu 
705                 710                 715                 720 


Asp Asn Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Val Phe Tyr Arg 
                725                 730                 735     


Pro Ala Ser Ile Ala Glu Asn Glu Leu Val Ile His Lys Ala Gly Glu 
            740                 745                 750         


Gly Ile Lys Asn Lys Asn Pro Asn Arg Ala Lys Val Lys Glu Thr Ser 
        755                 760                 765             


Thr Phe Ser Tyr Asp Ile Val Lys Asp Lys Arg Tyr Ser Lys Tyr Lys 
    770                 775                 780                 


Phe Thr Leu His Ile Pro Ile Thr Met Asn Phe Gly Val Asp Glu Val 
785                 790                 795                 800 


Arg Arg Phe Asn Asp Val Ile Asn Asn Ala Leu Arg Thr Asp Asp Asn 
                805                 810                 815     


Val Asn Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Val 
            820                 825                 830         


Val Val Ile Asn Ser Glu Gly Lys Ile Leu Glu Gln Ile Ser Leu Asn 
        835                 840                 845             


Ser Ile Ile Asn Lys Glu Tyr Asp Ile Glu Thr Asn Tyr His Ala Leu 
    850                 855                 860                 


Leu Asp Glu Arg Glu Asp Asp Arg Asn Lys Ala Arg Lys Asp Trp Asn 
865                 870                 875                 880 


Thr Ile Glu Asn Ile Lys Glu Leu Lys Thr Gly Tyr Leu Ser Gln Val 
                885                 890                 895     


Val Asn Val Val Ala Lys Leu Val Leu Lys Tyr Asn Ala Ile Ile Cys 
            900                 905                 910         


Leu Glu Asp Leu Asn Phe Gly Phe Lys Arg Gly Arg Gln Lys Val Glu 
        915                 920                 925             


Lys Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Glu Lys Leu Asn 
    930                 935                 940                 


Tyr Leu Val Ile Asp Lys Ser Arg Glu Gln Val Ser Pro Glu Lys Met 
945                 950                 955                 960 


Gly Gly Ala Leu Asn Ala Leu Gln Leu Thr Ser Lys Phe Lys Ser Phe 
                965                 970                 975     


Ala Glu Leu Gly Lys Gln Ser Gly Ile Ile Tyr Tyr Val Pro Ala Tyr 
            980                 985                 990         


Leu Thr Ser Lys Ile Asp Pro Thr  Thr Gly Phe Val Asn  Leu Phe Tyr 
        995                 1000                 1005             


Ile Lys  Tyr Glu Asn Ile Glu  Lys Ala Lys Gln Phe  Phe Asp Gly 
    1010                 1015                 1020             


Phe Asp  Phe Ile Arg Phe Asn  Lys Lys Asp Asp Met  Phe Glu Phe 
    1025                 1030                 1035             


Ser Phe  Asp Tyr Lys Ser Phe  Thr Gln Lys Ala Cys  Gly Ile Arg 
    1040                 1045                 1050             


Ser Lys  Trp Ile Val Tyr Thr  Asn Gly Glu Arg Ile  Ile Lys Tyr 
    1055                 1060                 1065             


Pro Asn  Pro Glu Lys Asn Asn  Leu Phe Asp Glu Lys  Val Ile Asn 
    1070                 1075                 1080             


Val Thr  Asp Glu Ile Lys Gly  Leu Phe Lys Gln Tyr  Arg Ile Pro 
    1085                 1090                 1095             


Tyr Glu  Asn Gly Glu Asp Ile  Lys Glu Ile Ile Ile  Ser Lys Ala 
    1100                 1105                 1110             


Glu Ala  Asp Phe Tyr Lys Arg  Leu Phe Arg Leu Leu  His Gln Thr 
    1115                 1120                 1125             


Leu Gln  Met Arg Asn Ser Thr  Ser Asp Gly Thr Arg  Asp Tyr Ile 
    1130                 1135                 1140             


Ile Ser  Pro Val Lys Asn Asp  Arg Gly Glu Phe Phe  Cys Ser Glu 
    1145                 1150                 1155             


Phe Ser  Glu Gly Thr Met Pro  Lys Asp Ala Asp Ala  Asn Gly Ala 
    1160                 1165                 1170             


Tyr Asn  Ile Ala Arg Lys Gly  Leu Trp Val Leu Glu  Gln Ile Arg 
    1175                 1180                 1185             


Gln Lys  Asp Glu Gly Glu Lys  Val Asn Leu Ser Met  Thr Asn Ala 
    1190                 1195                 1200             


Glu Trp  Leu Lys Tyr Ala Gln  Leu His Leu Leu 
    1205                 1210                 


<210> 10
<211> 1129
<212> PRT
<213> Alicyclobacillus acidoterrestris

<400> 10
Met Ala Val Lys Ser Ile Lys Val Lys Leu Arg Leu Asp Asp Met Pro 
1               5                   10                  15      


Glu Ile Arg Ala Gly Leu Trp Lys Leu His Lys Glu Val Asn Ala Gly 
            20                  25                  30          


Val Arg Tyr Tyr Thr Glu Trp Leu Ser Leu Leu Arg Gln Glu Asn Leu 
        35                  40                  45              


Tyr Arg Arg Ser Pro Asn Gly Asp Gly Glu Gln Glu Cys Asp Lys Thr 
    50                  55                  60                  


Ala Glu Glu Cys Lys Ala Glu Leu Leu Glu Arg Leu Arg Ala Arg Gln 
65                  70                  75                  80  


Val Glu Asn Gly His Arg Gly Pro Ala Gly Ser Asp Asp Glu Leu Leu 
                85                  90                  95      


Gln Leu Ala Arg Gln Leu Tyr Glu Leu Leu Val Pro Gln Ala Ile Gly 
            100                 105                 110         


Ala Lys Gly Asp Ala Gln Gln Ile Ala Arg Lys Phe Leu Ser Pro Leu 
        115                 120                 125             


Ala Asp Lys Asp Ala Val Gly Gly Leu Gly Ile Ala Lys Ala Gly Asn 
    130                 135                 140                 


Lys Pro Arg Trp Val Arg Met Arg Glu Ala Gly Glu Pro Gly Trp Glu 
145                 150                 155                 160 


Glu Glu Lys Glu Lys Ala Glu Thr Arg Lys Ser Ala Asp Arg Thr Ala 
                165                 170                 175     


Asp Val Leu Arg Ala Leu Ala Asp Phe Gly Leu Lys Pro Leu Met Arg 
            180                 185                 190         


Val Tyr Thr Asp Ser Glu Met Ser Ser Val Glu Trp Lys Pro Leu Arg 
        195                 200                 205             


Lys Gly Gln Ala Val Arg Thr Trp Asp Arg Asp Met Phe Gln Gln Ala 
    210                 215                 220                 


Ile Glu Arg Met Met Ser Trp Glu Ser Trp Asn Gln Arg Val Gly Gln 
225                 230                 235                 240 


Glu Tyr Ala Lys Leu Val Glu Gln Lys Asn Arg Phe Glu Gln Lys Asn 
                245                 250                 255     


Phe Val Gly Gln Glu His Leu Val His Leu Val Asn Gln Leu Gln Gln 
            260                 265                 270         


Asp Met Lys Glu Ala Ser Pro Gly Leu Glu Ser Lys Glu Gln Thr Ala 
        275                 280                 285             


His Tyr Val Thr Gly Arg Ala Leu Arg Gly Ser Asp Lys Val Phe Glu 
    290                 295                 300                 


Lys Trp Gly Lys Leu Ala Pro Asp Ala Pro Phe Asp Leu Tyr Asp Ala 
305                 310                 315                 320 


Glu Ile Lys Asn Val Gln Arg Arg Asn Thr Arg Arg Phe Gly Ser His 
                325                 330                 335     


Asp Leu Phe Ala Lys Leu Ala Glu Pro Glu Tyr Gln Ala Leu Trp Arg 
            340                 345                 350         


Glu Asp Ala Ser Phe Leu Thr Arg Tyr Ala Val Tyr Asn Ser Ile Leu 
        355                 360                 365             


Arg Lys Leu Asn His Ala Lys Met Phe Ala Thr Phe Thr Leu Pro Asp 
    370                 375                 380                 


Ala Thr Ala His Pro Ile Trp Thr Arg Phe Asp Lys Leu Gly Gly Asn 
385                 390                 395                 400 


Leu His Gln Tyr Thr Phe Leu Phe Asn Glu Phe Gly Glu Arg Arg His 
                405                 410                 415     


Ala Ile Arg Phe His Lys Leu Leu Lys Val Glu Asn Gly Val Ala Arg 
            420                 425                 430         


Glu Val Asp Asp Val Thr Val Pro Ile Ser Met Ser Glu Gln Leu Asp 
        435                 440                 445             


Asn Leu Leu Pro Arg Asp Pro Asn Glu Pro Ile Ala Leu Tyr Phe Arg 
    450                 455                 460                 


Asp Tyr Gly Ala Glu Gln His Phe Thr Gly Glu Phe Gly Gly Ala Lys 
465                 470                 475                 480 


Ile Gln Cys Arg Arg Asp Gln Leu Ala His Met His Arg Arg Arg Gly 
                485                 490                 495     


Ala Arg Asp Val Tyr Leu Asn Val Ser Val Arg Val Gln Ser Gln Ser 
            500                 505                 510         


Glu Ala Arg Gly Glu Arg Arg Pro Pro Tyr Ala Ala Val Phe Arg Leu 
        515                 520                 525             


Val Gly Asp Asn His Arg Ala Phe Val His Phe Asp Lys Leu Ser Asp 
    530                 535                 540                 


Tyr Leu Ala Glu His Pro Asp Asp Gly Lys Leu Gly Ser Glu Gly Leu 
545                 550                 555                 560 


Leu Ser Gly Leu Arg Val Met Ser Val Asp Leu Gly Leu Arg Thr Ser 
                565                 570                 575     


Ala Ser Ile Ser Val Phe Arg Val Ala Arg Lys Asp Glu Leu Lys Pro 
            580                 585                 590         


Asn Ser Lys Gly Arg Val Pro Phe Phe Phe Pro Ile Lys Gly Asn Asp 
        595                 600                 605             


Asn Leu Val Ala Val His Glu Arg Ser Gln Leu Leu Lys Leu Pro Gly 
    610                 615                 620                 


Glu Thr Glu Ser Lys Asp Leu Arg Ala Ile Arg Glu Glu Arg Gln Arg 
625                 630                 635                 640 


Thr Leu Arg Gln Leu Arg Thr Gln Leu Ala Tyr Leu Arg Leu Leu Val 
                645                 650                 655     


Arg Cys Gly Ser Glu Asp Val Gly Arg Arg Glu Arg Ser Trp Ala Lys 
            660                 665                 670         


Leu Ile Glu Gln Pro Val Asp Ala Ala Asn His Met Thr Pro Asp Trp 
        675                 680                 685             


Arg Glu Ala Phe Glu Asn Glu Leu Gln Lys Leu Lys Ser Leu His Gly 
    690                 695                 700                 


Ile Cys Ser Asp Lys Glu Trp Met Asp Ala Val Tyr Glu Ser Val Arg 
705                 710                 715                 720 


Arg Val Trp Arg His Met Gly Lys Gln Val Arg Asp Trp Arg Lys Asp 
                725                 730                 735     


Val Arg Ser Gly Glu Arg Pro Lys Ile Arg Gly Tyr Ala Lys Asp Val 
            740                 745                 750         


Val Gly Gly Asn Ser Ile Glu Gln Ile Glu Tyr Leu Glu Arg Gln Tyr 
        755                 760                 765             


Lys Phe Leu Lys Ser Trp Ser Phe Phe Gly Lys Val Ser Gly Gln Val 
    770                 775                 780                 


Ile Arg Ala Glu Lys Gly Ser Arg Phe Ala Ile Thr Leu Arg Glu His 
785                 790                 795                 800 


Ile Asp His Ala Lys Glu Asp Arg Leu Lys Lys Leu Ala Asp Arg Ile 
                805                 810                 815     


Ile Met Glu Ala Leu Gly Tyr Val Tyr Ala Leu Asp Glu Arg Gly Lys 
            820                 825                 830         


Gly Lys Trp Val Ala Lys Tyr Pro Pro Cys Gln Leu Ile Leu Leu Glu 
        835                 840                 845             


Glu Leu Ser Glu Tyr Gln Phe Asn Asn Asp Arg Pro Pro Ser Glu Asn 
    850                 855                 860                 


Asn Gln Leu Met Gln Trp Ser His Arg Gly Val Phe Gln Glu Leu Ile 
865                 870                 875                 880 


Asn Gln Ala Gln Val His Asp Leu Leu Val Gly Thr Met Tyr Ala Ala 
                885                 890                 895     


Phe Ser Ser Arg Phe Asp Ala Arg Thr Gly Ala Pro Gly Ile Arg Cys 
            900                 905                 910         


Arg Arg Val Pro Ala Arg Cys Thr Gln Glu His Asn Pro Glu Pro Phe 
        915                 920                 925             


Pro Trp Trp Leu Asn Lys Phe Val Val Glu His Thr Leu Asp Ala Cys 
    930                 935                 940                 


Pro Leu Arg Ala Asp Asp Leu Ile Pro Thr Gly Glu Gly Glu Ile Phe 
945                 950                 955                 960 


Val Ser Pro Phe Ser Ala Glu Glu Gly Asp Phe His Gln Ile His Ala 
                965                 970                 975     


Asp Leu Asn Ala Ala Gln Asn Leu Gln Gln Arg Leu Trp Ser Asp Phe 
            980                 985                 990         


Asp Ile Ser Gln Ile Arg Leu Arg  Cys Asp Trp Gly Glu  Val Asp Gly 
        995                 1000                 1005             


Glu Leu  Val Leu Ile Pro Arg  Leu Thr Gly Lys Arg  Thr Ala Asp 
    1010                 1015                 1020             


Ser Tyr  Ser Asn Lys Val Phe  Tyr Thr Asn Thr Gly  Val Thr Tyr 
    1025                 1030                 1035             


Tyr Glu  Arg Glu Arg Gly Lys  Lys Arg Arg Lys Val  Phe Ala Gln 
    1040                 1045                 1050             


Glu Lys  Leu Ser Glu Glu Glu  Ala Glu Leu Leu Val  Glu Ala Asp 
    1055                 1060                 1065             


Glu Ala  Arg Glu Lys Ser Val  Val Leu Met Arg Asp  Pro Ser Gly 
    1070                 1075                 1080             


Ile Ile  Asn Arg Gly Asn Trp  Thr Arg Gln Lys Glu  Phe Trp Ser 
    1085                 1090                 1095             


Met Val  Asn Gln Arg Ile Glu  Gly Tyr Leu Val Lys  Gln Ile Arg 
    1100                 1105                 1110             


Ser Arg  Val Pro Leu Gln Asp  Ser Ala Cys Glu Asn  Thr Gly Asp 
    1115                 1120                 1125             


Ile 
    


<210> 11
<211> 1224
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Lys Lys Ile Asp Asn Phe Val Gly Cys Tyr Pro Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Ile Gly Lys Thr Gln Glu Asn Ile Glu 
            20                  25                  30          


Lys Lys Arg Leu Val Glu Glu Asp Glu Val Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Ala Val Lys Lys Leu Ile Asp Arg Tyr His Arg Glu Phe Ile Glu Gly 
    50                  55                  60                  


Val Leu Asp Asn Val Lys Leu Asp Gly Leu Glu Glu Tyr Tyr Met Leu 
65                  70                  75                  80  


Phe Asn Lys Ser Asp Arg Glu Glu Ser Asp Asn Lys Lys Ile Glu Ile 
                85                  90                  95      


Met Glu Glu Arg Phe Arg Arg Val Ile Ser Lys Ser Phe Lys Asn Asn 
            100                 105                 110         


Glu Glu Tyr Lys Lys Ile Phe Ser Lys Lys Ile Ile Glu Glu Ile Leu 
        115                 120                 125             


Pro Asn Tyr Ile Lys Asp Glu Glu Glu Lys Glu Leu Val Lys Gly Phe 
    130                 135                 140                 


Lys Gly Phe Tyr Thr Ala Phe Val Gly Tyr Ala Gln Asn Arg Glu Asn 
145                 150                 155                 160 


Met Tyr Ser Asp Glu Lys Lys Ser Thr Ala Ile Ser Tyr Arg Ile Val 
                165                 170                 175     


Asn Glu Asn Met Pro Arg Phe Ile Thr Asn Ile Lys Val Phe Glu Lys 
            180                 185                 190         


Ala Lys Ser Ile Leu Asp Val Asp Lys Ile Asn Glu Ile Asn Glu Tyr 
        195                 200                 205             


Ile Leu Asn Asn Asp Tyr Tyr Val Asp Asp Phe Phe Asn Ile Asp Phe 
    210                 215                 220                 


Phe Asn Tyr Val Leu Asn Gln Lys Gly Ile Asp Ile Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Ile Val Thr Gly Asp Gly Arg Lys Ile Gln Gly Leu Asn 
                245                 250                 255     


Glu Cys Ile Asn Leu Tyr Asn Gln Glu Asn Lys Lys Ile Arg Leu Pro 
            260                 265                 270         


Gln Phe Lys Pro Leu Tyr Lys Gln Ile Leu Ser Glu Ser Glu Ser Met 
        275                 280                 285             


Ser Phe Tyr Ile Asp Glu Ile Glu Ser Asp Asp Met Leu Ile Asp Met 
    290                 295                 300                 


Leu Lys Glu Ser Leu Gln Ile Asp Ser Thr Ile Asn Asn Ala Ile Asp 
305                 310                 315                 320 


Asp Leu Lys Val Leu Phe Asn Asn Ile Phe Asp Tyr Asp Leu Ser Gly 
                325                 330                 335     


Ile Phe Ile Asn Asn Gly Leu Pro Ile Thr Thr Ile Ser Asn Asp Val 
            340                 345                 350         


Tyr Gly Gln Trp Ser Thr Ile Ser Asp Gly Trp Asn Glu Arg Tyr Asp 
        355                 360                 365             


Val Leu Ser Asn Ala Lys Asp Lys Glu Ser Glu Lys Tyr Phe Glu Lys 
    370                 375                 380                 


Arg Arg Lys Glu Tyr Lys Lys Val Lys Ser Phe Ser Ile Ser Asp Leu 
385                 390                 395                 400 


Gln Glu Leu Gly Gly Lys Asp Leu Ser Ile Cys Lys Lys Ile Asn Glu 
                405                 410                 415     


Ile Ile Ser Glu Met Ile Asp Asp Tyr Lys Ser Lys Ile Glu Glu Ile 
            420                 425                 430         


Gln Tyr Leu Phe Asp Ile Lys Glu Leu Glu Lys Pro Leu Val Thr Asp 
        435                 440                 445             


Leu Asn Lys Ile Glu Leu Ile Lys Asn Ser Leu Asp Gly Leu Lys Arg 
    450                 455                 460                 


Ile Glu Arg Tyr Val Ile Pro Phe Leu Gly Thr Gly Lys Glu Gln Asn 
465                 470                 475                 480 


Arg Asp Glu Val Phe Tyr Gly Tyr Phe Ile Lys Cys Ile Asp Ala Ile 
                485                 490                 495     


Lys Glu Ile Asp Gly Val Tyr Asn Lys Thr Arg Asn Tyr Leu Thr Lys 
            500                 505                 510         


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Glu Asn Pro Gln 
        515                 520                 525             


Leu Met Gly Gly Trp Asp Arg Asn Lys Glu Ser Asp Tyr Arg Ser Thr 
    530                 535                 540                 


Leu Leu Arg Lys Asn Gly Lys Tyr Tyr Val Ala Ile Ile Asp Lys Ser 
545                 550                 555                 560 


Ser Ser Asn Cys Met Met Asn Ile Glu Glu Asp Glu Asn Asp Asn Tyr 
                565                 570                 575     


Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro 
            580                 585                 590         


Lys Val Phe Phe Ser Lys Lys Asn Arg Glu Tyr Phe Ala Pro Ser Lys 
        595                 600                 605             


Glu Ile Glu Arg Ile Tyr Ser Thr Gly Thr Phe Lys Lys Asp Thr Asn 
    610                 615                 620                 


Phe Val Lys Lys Asp Cys Glu Asn Leu Ile Thr Phe Tyr Lys Asp Ser 
625                 630                 635                 640 


Leu Asp Arg His Glu Asp Trp Ser Lys Ser Phe Asp Phe Ser Phe Lys 
                645                 650                 655     


Glu Ser Ser Ala Tyr Arg Asp Ile Ser Glu Phe Tyr Arg Asp Val Glu 
            660                 665                 670         


Lys Gln Gly Tyr Arg Val Ser Phe Asp Leu Leu Ser Ser Asn Ala Val 
        675                 680                 685             


Asn Thr Leu Val Glu Glu Gly Lys Leu Tyr Leu Phe Gln Leu Tyr Asn 
    690                 695                 700                 


Lys Asp Phe Ser Glu Lys Ser His Gly Ile Pro Asn Leu His Thr Met 
705                 710                 715                 720 


Tyr Phe Arg Ser Leu Phe Asp Asp Asn Asn Lys Gly Asn Ile Arg Leu 
                725                 730                 735     


Asn Gly Gly Ala Glu Met Phe Met Arg Arg Ala Ser Leu Asn Lys Gln 
            740                 745                 750         


Asp Val Thr Val His Lys Ala Asn Gln Pro Ile Lys Asn Lys Asn Leu 
        755                 760                 765             


Leu Asn Pro Lys Lys Thr Thr Thr Leu Pro Tyr Asp Val Tyr Lys Asp 
    770                 775                 780                 


Lys Arg Phe Thr Glu Asp Gln Tyr Glu Val His Ile Pro Ile Thr Met 
785                 790                 795                 800 


Asn Lys Val Pro Asn Asn Pro Tyr Lys Ile Asn His Met Val Arg Glu 
                805                 810                 815     


Gln Leu Val Lys Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp Arg Gly 
            820                 825                 830         


Glu Arg Asn Leu Ile Tyr Val Val Val Val Asp Gly Gln Gly His Ile 
        835                 840                 845             


Val Glu Gln Leu Ser Leu Asn Glu Ile Ile Asn Glu Asn Asn Gly Ile 
    850                 855                 860                 


Ser Ile Arg Thr Asp Tyr His Thr Leu Leu Asp Ala Lys Glu Arg Glu 
865                 870                 875                 880 


Arg Asp Glu Ser Arg Lys Gln Trp Lys Gln Ile Glu Asn Ile Lys Glu 
                885                 890                 895     


Leu Lys Glu Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys Glu Leu 
            900                 905                 910         


Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn Ser Gly 
        915                 920                 925             


Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln Lys Phe 
    930                 935                 940                 


Glu Lys Met Leu Ile Thr Lys Leu Asn Tyr Met Val Asp Lys Lys Lys 
945                 950                 955                 960 


Asp Tyr Asn Lys Pro Gly Gly Val Leu Asn Gly Tyr Gln Leu Thr Thr 
                965                 970                 975     


Gln Phe Glu Ser Phe Ser Lys Met Gly Thr Gln Asn Gly Ile Met Phe 
            980                 985                 990         


Tyr Ile Pro Ala Trp Leu Thr Ser  Lys Met Asp Pro Thr  Thr Gly Phe 
        995                 1000                 1005             


Val Asp  Leu Leu Lys Pro Lys  Tyr Lys Asn Lys Ala  Asp Ala Gln 
    1010                 1015                 1020             


Lys Phe  Phe Ser Gln Phe Asp  Ser Ile Arg Tyr Asp  Asn Gln Glu 
    1025                 1030                 1035             


Asp Ala  Phe Val Phe Lys Val  Asn Tyr Thr Lys Phe  Pro Arg Thr 
    1040                 1045                 1050             


Asp Ala  Asp Tyr Asn Lys Glu  Trp Glu Ile Tyr Thr  Asn Gly Glu 
    1055                 1060                 1065             


Arg Ile  Arg Val Phe Arg Asn  Pro Lys Lys Asn Asn  Glu Tyr Asp 
    1070                 1075                 1080             


Tyr Glu  Thr Val Asn Val Ser  Glu Arg Met Lys Glu  Leu Phe Asp 
    1085                 1090                 1095             


Ser Tyr  Asp Leu Leu Tyr Asp  Lys Gly Glu Leu Lys  Glu Thr Ile 
    1100                 1105                 1110             


Cys Glu  Met Glu Glu Ser Lys  Phe Phe Glu Glu Leu  Ile Lys Leu 
    1115                 1120                 1125             


Phe Arg  Leu Thr Leu Gln Met  Arg Asn Ser Ile Ser  Gly Arg Thr 
    1130                 1135                 1140             


Asp Val  Asp Tyr Leu Ile Ser  Pro Val Lys Asn Ser  Asn Gly Tyr 
    1145                 1150                 1155             


Phe Tyr  Asn Ser Asn Asp Tyr  Lys Lys Glu Gly Ala  Lys Tyr Pro 
    1160                 1165                 1170             


Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val 
    1175                 1180                 1185             


Leu Trp  Ala Ile Glu Gln Phe  Lys Met Ala Asp Glu  Asp Lys Leu 
    1190                 1195                 1200             


Asp Lys  Thr Lys Ile Ser Ile  Lys Asn Gln Glu Trp  Leu Glu Tyr 
    1205                 1210                 1215             


Ala Gln  Thr His Cys Glu 
    1220                 


<210> 12
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Glu Val Gln Lys Thr Val Met Lys Thr Leu Ser Leu Arg Ile Leu 
1               5                   10                  15      


Arg Pro Leu Tyr Ser Gln Glu Ile Glu Lys Glu Ile Lys Glu Glu Lys 
            20                  25                  30          


Glu Arg Arg Lys Gln Ala Gly Gly Thr Gly Glu Leu Asp Gly Gly Phe 
        35                  40                  45              


Tyr Lys Lys Leu Glu Lys Lys His Ser Glu Met Phe Ser Phe Asp Arg 
    50                  55                  60                  


Leu Asn Leu Leu Leu Asn Gln Leu Gln Arg Glu Ile Ala Lys Val Tyr 
65                  70                  75                  80  


Asn His Ala Ile Ser Glu Leu Tyr Ile Ala Thr Ile Ala Gln Gly Asn 
                85                  90                  95      


Lys Ser Asn Lys His Tyr Ile Ser Ser Ile Val Tyr Asn Arg Ala Tyr 
            100                 105                 110         


Gly Tyr Phe Tyr Asn Ala Tyr Ile Ala Leu Gly Ile Cys Ser Lys Val 
        115                 120                 125             


Glu Ala Asn Phe Arg Ser Asn Glu Leu Leu Thr Gln Gln Ser Ala Leu 
    130                 135                 140                 


Pro Thr Ala Lys Ser Asp Asn Phe Pro Ile Val Leu His Lys Gln Lys 
145                 150                 155                 160 


Gly Ala Glu Gly Glu Asp Gly Gly Phe Arg Ile Ser Thr Glu Gly Ser 
                165                 170                 175     


Asp Leu Ile Phe Glu Ile Pro Ile Pro Phe Tyr Glu Tyr Asn Gly Glu 
            180                 185                 190         


Asn Arg Lys Glu Pro Tyr Lys Trp Val Lys Lys Gly Gly Gln Lys Pro 
        195                 200                 205             


Val Leu Lys Leu Ile Leu Ser Thr Phe Arg Arg Gln Arg Asn Lys Gly 
    210                 215                 220                 


Trp Ala Lys Asp Glu Gly Thr Asp Ala Glu Ile Arg Lys Val Thr Glu 
225                 230                 235                 240 


Gly Lys Tyr Gln Val Ser Gln Ile Glu Ile Asn Arg Gly Lys Lys Leu 
                245                 250                 255     


Gly Glu His Gln Lys Trp Phe Ala Asn Phe Ser Ile Glu Gln Pro Ile 
            260                 265                 270         


Tyr Glu Arg Lys Pro Asn Arg Ser Ile Val Gly Gly Leu Asp Val Gly 
        275                 280                 285             


Ile Arg Ser Pro Leu Val Cys Ala Ile Asn Asn Ser Phe Ser Arg Tyr 
    290                 295                 300                 


Ser Val Asp Ser Asn Asp Val Phe Lys Phe Ser Lys Gln Val Phe Ala 
305                 310                 315                 320 


Phe Arg Arg Arg Leu Leu Ser Lys Asn Ser Leu Lys Arg Lys Gly His 
                325                 330                 335     


Gly Ala Ala His Lys Leu Glu Pro Ile Thr Glu Met Thr Glu Lys Asn 
            340                 345                 350         


Asp Lys Phe Arg Lys Lys Ile Ile Glu Arg Trp Ala Lys Glu Val Thr 
        355                 360                 365             


Asn Phe Phe Val Lys Asn Gln Val Gly Ile Val Gln Ile Glu Asp Leu 
    370                 375                 380                 


Ser Thr Met Lys Asp Arg Glu Asp His Phe Phe Asn Gln Tyr Leu Arg 
385                 390                 395                 400 


Gly Phe Trp Pro Tyr Tyr Gln Met Gln Thr Leu Ile Glu Asn Lys Leu 
                405                 410                 415     


Lys Glu Tyr Gly Ile Glu Val Lys Arg Val Gln Ala Lys Tyr Thr Ser 
            420                 425                 430         


Gln Leu Cys Ser Asn Pro Asn Cys Arg Tyr Trp Asn Asn Tyr Phe Asn 
        435                 440                 445             


Phe Glu Tyr Arg Lys Val Asn Lys Phe Pro Lys Phe Lys Cys Glu Lys 
    450                 455                 460                 


Cys Asn Leu Glu Ile Ser Ala Asp Tyr Asn Ala Ala Arg Asn Leu Ser 
465                 470                 475                 480 


Thr Pro Asp Ile Glu Lys Phe Val Ala Lys Ala Thr Lys Gly Ile Asn 
                485                 490                 495     


Leu Pro Glu Lys 
            500 


<210> 13
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Glu Glu Ala Lys Thr Val Ser Lys Thr Leu Ser Leu Arg Ile Leu 
1               5                   10                  15      


Arg Pro Leu Tyr Ser Ala Glu Ile Glu Lys Glu Ile Lys Glu Glu Lys 
            20                  25                  30          


Glu Arg Arg Lys Gln Gly Gly Lys Ser Gly Glu Leu Asp Ser Gly Phe 
        35                  40                  45              


Tyr Lys Lys Leu Glu Lys Lys His Thr Gln Met Phe Gly Trp Asp Lys 
    50                  55                  60                  


Leu Asn Leu Met Leu Ser Gln Leu Gln Arg Gln Ile Ala Arg Val Phe 
65                  70                  75                  80  


Asn Gln Ser Ile Ser Glu Leu Tyr Ile Glu Thr Val Ile Gln Gly Lys 
                85                  90                  95      


Lys Ser Asn Lys His Tyr Thr Ser Lys Ile Val Tyr Asn Arg Ala Tyr 
            100                 105                 110         


Ser Val Phe Tyr Asn Ala Tyr Leu Ala Leu Gly Ile Thr Ser Lys Val 
        115                 120                 125             


Glu Ala Asn Phe Arg Ser Thr Glu Leu Leu Met Gln Lys Ser Ser Leu 
    130                 135                 140                 


Pro Thr Ala Lys Ser Asp Asn Phe Pro Ile Leu Leu His Lys Gln Lys 
145                 150                 155                 160 


Gly Val Glu Gly Glu Glu Gly Gly Phe Lys Ile Ser Ala Asp Gly Asn 
                165                 170                 175     


Asp Leu Ile Phe Glu Ile Pro Ile Pro Phe Tyr Glu Tyr Asp Ser Ala 
            180                 185                 190         


Asn Lys Lys Glu Pro Phe Lys Trp Ile Lys Lys Gly Gly Gln Lys Pro 
        195                 200                 205             


Thr Ile Lys Leu Ile Leu Ser Thr Phe Arg Arg Gln Arg Asn Lys Gly 
    210                 215                 220                 


Trp Ala Lys Asp Glu Gly Thr Asp Ala Glu Ile Arg Lys Val Ile Glu 
225                 230                 235                 240 


Gly Lys Tyr Gln Val Ser His Ile Glu Ile Asn Arg Gly Lys Lys Leu 
                245                 250                 255     


Gly Asp His Gln Lys Trp Phe Val Asn Phe Thr Ile Glu Gln Pro Ile 
            260                 265                 270         


Tyr Glu Arg Lys Leu Asp Lys Asn Ile Ile Gly Gly Ile Asp Val Gly 
        275                 280                 285             


Ile Lys Ser Pro Leu Val Cys Ala Val Asn Asn Ser Phe Ala Arg Tyr 
    290                 295                 300                 


Ser Val Asp Ser Asn Asp Val Leu Lys Phe Ser Lys Gln Ala Phe Ala 
305                 310                 315                 320 


Phe Arg Arg Arg Leu Leu Ser Lys Asn Ser Leu Lys Arg Ser Gly His 
                325                 330                 335     


Gly Ser Lys Asn Lys Leu Asp Pro Ile Thr Arg Met Thr Glu Lys Asn 
            340                 345                 350         


Asp Arg Phe Arg Lys Lys Ile Ile Glu Arg Trp Ala Lys Glu Val Thr 
        355                 360                 365             


Asn Phe Phe Ile Lys Asn Gln Val Gly Thr Val Gln Ile Glu Asp Leu 
    370                 375                 380                 


Ser Thr Met Lys Asp Arg Gln Asp Asn Phe Phe Asn Gln Tyr Leu Arg 
385                 390                 395                 400 


Gly Phe Trp Pro Tyr Tyr Gln Met Gln Asn Leu Ile Glu Asn Lys Leu 
                405                 410                 415     


Lys Glu Tyr Gly Ile Glu Thr Lys Arg Ile Lys Ala Arg Tyr Thr Ser 
            420                 425                 430         


Gln Leu Cys Ser Asn Pro Ser Cys Arg His Trp Asn Ser Tyr Phe Ser 
        435                 440                 445             


Phe Asp His Arg Lys Thr Asn Asn Phe Pro Lys Phe Lys Cys Glu Lys 
    450                 455                 460                 


Cys Ala Leu Glu Ile Ser Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ser 
465                 470                 475                 480 


Thr Pro Asp Ile Glu Lys Phe Val Ala Lys Ala Thr Lys Gly Ile Asn 
                485                 490                 495     


Leu Pro Asp Lys Asn Glu Asn Val Ile Leu Glu 
            500                 505         


<210> 14
<211> 529
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Ala Lys Asn Thr Ile Thr Lys Thr Leu Lys Leu Arg Ile Val Arg 
1               5                   10                  15      


Pro Tyr Asn Ser Ala Glu Val Glu Lys Ile Val Ala Asp Glu Lys Asn 
            20                  25                  30          


Asn Arg Glu Lys Ile Ala Leu Glu Lys Asn Lys Asp Lys Val Lys Glu 
        35                  40                  45              


Ala Cys Ser Lys His Leu Lys Val Ala Ala Tyr Cys Thr Thr Gln Val 
    50                  55                  60                  


Glu Arg Asn Ala Cys Leu Phe Cys Lys Ala Arg Lys Leu Asp Asp Lys 
65                  70                  75                  80  


Phe Tyr Gln Lys Leu Arg Gly Gln Phe Pro Asp Ala Val Phe Trp Gln 
                85                  90                  95      


Glu Ile Ser Glu Ile Phe Arg Gln Leu Gln Lys Gln Ala Ala Glu Ile 
            100                 105                 110         


Tyr Asn Gln Ser Leu Ile Glu Leu Tyr Tyr Glu Ile Phe Ile Lys Gly 
        115                 120                 125             


Lys Gly Ile Ala Asn Ala Ser Ser Val Glu His Tyr Leu Ser Asp Val 
    130                 135                 140                 


Cys Tyr Thr Arg Ala Ala Glu Leu Phe Lys Asn Ala Ala Ile Ala Ser 
145                 150                 155                 160 


Gly Leu Arg Ser Lys Ile Lys Ser Asn Phe Arg Leu Lys Glu Leu Lys 
                165                 170                 175     


Asn Met Lys Ser Gly Leu Pro Thr Thr Lys Ser Asp Asn Phe Pro Ile 
            180                 185                 190         


Pro Leu Val Lys Gln Lys Gly Gly Gln Tyr Thr Gly Phe Glu Ile Ser 
        195                 200                 205             


Asn His Asn Ser Asp Phe Ile Ile Lys Ile Pro Phe Gly Arg Trp Gln 
    210                 215                 220                 


Val Lys Lys Glu Ile Asp Lys Tyr Arg Pro Trp Glu Lys Phe Asp Phe 
225                 230                 235                 240 


Glu Gln Val Gln Lys Ser Pro Lys Pro Ile Ser Leu Leu Leu Ser Thr 
                245                 250                 255     


Gln Arg Arg Lys Arg Asn Lys Gly Trp Ser Lys Asp Glu Gly Thr Glu 
            260                 265                 270         


Ala Glu Ile Lys Lys Val Met Asn Gly Asp Tyr Gln Thr Ser Tyr Ile 
        275                 280                 285             


Glu Val Lys Arg Gly Ser Lys Ile Gly Glu Lys Ser Ala Trp Met Leu 
    290                 295                 300                 


Asn Leu Ser Ile Asp Val Pro Lys Ile Asp Lys Gly Val Asp Pro Ser 
305                 310                 315                 320 


Ile Ile Gly Gly Ile Asp Val Gly Val Lys Ser Pro Leu Val Cys Ala 
                325                 330                 335     


Ile Asn Asn Ala Phe Ser Arg Tyr Ser Ile Ser Asp Asn Asp Leu Phe 
            340                 345                 350         


His Phe Asn Lys Lys Met Phe Ala Arg Arg Arg Ile Leu Leu Lys Lys 
        355                 360                 365             


Asn Arg His Lys Arg Ala Gly His Gly Ala Lys Asn Lys Leu Lys Pro 
    370                 375                 380                 


Ile Thr Ile Leu Thr Glu Lys Ser Glu Arg Phe Arg Lys Lys Leu Ile 
385                 390                 395                 400 


Glu Arg Trp Ala Cys Glu Ile Ala Asp Phe Phe Ile Lys Asn Lys Val 
                405                 410                 415     


Gly Thr Val Gln Met Glu Asn Leu Glu Ser Met Lys Arg Lys Glu Asp 
            420                 425                 430         


Ser Tyr Phe Asn Ile Arg Leu Arg Gly Phe Trp Pro Tyr Ala Glu Met 
        435                 440                 445             


Gln Asn Lys Ile Glu Phe Lys Leu Lys Gln Tyr Gly Ile Glu Ile Arg 
    450                 455                 460                 


Lys Val Ala Pro Asn Asn Thr Ser Lys Thr Cys Ser Lys Cys Gly His 
465                 470                 475                 480 


Leu Asn Asn Tyr Phe Asn Phe Glu Tyr Arg Lys Lys Asn Lys Phe Pro 
                485                 490                 495     


His Phe Lys Cys Glu Lys Cys Asn Phe Lys Glu Asn Ala Asp Tyr Asn 
            500                 505                 510         


Ala Ala Leu Asn Ile Ser Asn Pro Lys Leu Lys Ser Thr Lys Glu Glu 
        515                 520                 525             


Pro 
    


<210> 15

<400> 15
000


<210> 16
<211> 726
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Glu Arg Gln Lys Val Pro Gln Ile Arg Lys Ile Val Arg Val Val 
1               5                   10                  15      


Pro Leu Arg Ile Leu Arg Pro Lys Tyr Ser Asp Val Ile Glu Asn Ala 
            20                  25                  30          


Leu Lys Lys Phe Lys Glu Lys Gly Asp Asp Thr Asn Thr Asn Asp Phe 
        35                  40                  45              


Trp Arg Ala Ile Arg Asp Arg Asp Thr Glu Phe Phe Arg Lys Glu Leu 
    50                  55                  60                  


Asn Phe Ser Glu Asp Glu Ile Asn Gln Leu Glu Arg Asp Thr Leu Phe 
65                  70                  75                  80  


Arg Val Gly Leu Asp Asn Arg Val Leu Phe Ser Tyr Phe Asp Phe Leu 
                85                  90                  95      


Gln Glu Lys Leu Met Lys Asp Tyr Asn Lys Ile Ile Ser Lys Leu Phe 
            100                 105                 110         


Ile Asn Arg Gln Ser Lys Ser Ser Phe Glu Asn Asp Leu Thr Asp Glu 
        115                 120                 125             


Glu Val Glu Glu Leu Ile Glu Lys Asp Val Thr Pro Phe Tyr Gly Ala 
    130                 135                 140                 


Tyr Ile Gly Lys Gly Ile Lys Ser Val Ile Lys Ser Asn Leu Gly Gly 
145                 150                 155                 160 


Lys Phe Ile Lys Ser Val Lys Ile Asp Arg Glu Thr Lys Lys Val Thr 
                165                 170                 175     


Lys Leu Thr Ala Ile Asn Ile Gly Leu Met Gly Leu Pro Val Ala Lys 
            180                 185                 190         


Ser Asp Thr Phe Pro Ile Lys Ile Ile Lys Thr Asn Pro Asp Tyr Ile 
        195                 200                 205             


Thr Phe Gln Lys Ser Thr Lys Glu Asn Leu Gln Lys Ile Glu Asp Tyr 
    210                 215                 220                 


Glu Thr Gly Ile Glu Tyr Gly Asp Leu Leu Val Gln Ile Thr Ile Pro 
225                 230                 235                 240 


Trp Phe Lys Asn Glu Asn Lys Asp Phe Ser Leu Ile Lys Thr Lys Glu 
                245                 250                 255     


Ala Ile Glu Tyr Tyr Lys Leu Asn Gly Val Gly Lys Lys Asp Leu Leu 
            260                 265                 270         


Asn Ile Asn Leu Val Leu Thr Thr Tyr His Ile Arg Lys Lys Lys Ser 
        275                 280                 285             


Trp Gln Ile Asp Gly Ser Ser Gln Ser Leu Val Arg Glu Met Ala Asn 
    290                 295                 300                 


Gly Glu Leu Glu Glu Lys Trp Lys Ser Phe Phe Asp Thr Phe Ile Lys 
305                 310                 315                 320 


Lys Tyr Gly Asp Glu Gly Lys Ser Ala Leu Val Lys Arg Arg Val Asn 
                325                 330                 335     


Lys Lys Ser Arg Ala Lys Gly Glu Lys Gly Arg Glu Leu Asn Leu Asp 
            340                 345                 350         


Glu Arg Ile Lys Arg Leu Tyr Asp Ser Ile Lys Ala Lys Ser Phe Pro 
        355                 360                 365             


Ser Glu Ile Asn Leu Ile Pro Glu Asn Tyr Lys Trp Lys Leu His Phe 
    370                 375                 380                 


Ser Ile Glu Ile Pro Pro Met Val Asn Asp Ile Asp Ser Asn Leu Tyr 
385                 390                 395                 400 


Gly Gly Ile Asp Phe Gly Glu Gln Asn Ile Ala Thr Leu Cys Val Lys 
                405                 410                 415     


Asn Ile Glu Lys Asp Asp Tyr Asp Phe Leu Thr Ile Tyr Gly Asn Asp 
            420                 425                 430         


Leu Leu Lys His Ala Gln Ala Ser Tyr Ala Arg Arg Arg Ile Met Arg 
        435                 440                 445             


Val Gln Asp Glu Tyr Lys Ala Arg Gly His Gly Lys Ser Arg Lys Thr 
    450                 455                 460                 


Lys Ala Gln Glu Asp Tyr Ser Glu Arg Met Gln Lys Leu Arg Gln Lys 
465                 470                 475                 480 


Ile Thr Glu Arg Leu Val Lys Gln Ile Ser Asp Phe Phe Leu Trp Arg 
                485                 490                 495     


Asn Lys Phe His Met Ala Val Cys Ser Leu Arg Tyr Glu Asp Leu Asn 
            500                 505                 510         


Thr Leu Tyr Lys Gly Glu Ser Val Lys Ala Lys Arg Met Arg Gln Phe 
        515                 520                 525             


Ile Asn Lys Gln Gln Leu Phe Asn Gly Ile Glu Arg Lys Leu Lys Asp 
    530                 535                 540                 


Tyr Asn Ser Glu Ile Tyr Val Asn Ser Arg Tyr Pro His Tyr Thr Ser 
545                 550                 555                 560 


Arg Leu Cys Ser Lys Cys Gly Lys Leu Asn Leu Tyr Phe Asp Phe Leu 
                565                 570                 575     


Lys Phe Arg Thr Lys Asn Ile Ile Ile Arg Lys Asn Pro Asp Gly Ser 
            580                 585                 590         


Glu Ile Lys Tyr Met Pro Phe Phe Ile Cys Glu Phe Cys Gly Trp Lys 
        595                 600                 605             


Gln Ala Gly Asp Lys Asn Ala Ser Ala Asn Ile Ala Asp Lys Asp Tyr 
    610                 615                 620                 


Gln Asp Lys Leu Asn Lys Glu Lys Glu Phe Cys Asn Ile Arg Lys Pro 
625                 630                 635                 640 


Lys Ser Lys Lys Glu Asp Ile Gly Glu Glu Asn Glu Glu Glu Arg Asp 
                645                 650                 655     


Tyr Ser Arg Arg Phe Asn Arg Asn Ser Phe Ile Tyr Asn Ser Leu Lys 
            660                 665                 670         


Lys Asp Asn Lys Leu Asn Gln Glu Lys Leu Phe Asp Glu Trp Lys Asn 
        675                 680                 685             


Gln Leu Lys Arg Lys Ile Asp Gly Arg Asn Lys Phe Glu Pro Lys Glu 
    690                 695                 700                 


Tyr Lys Asp Arg Phe Ser Tyr Leu Phe Ala Tyr Tyr Gln Glu Ile Ile 
705                 710                 715                 720 


Lys Asn Glu Ser Glu Ser 
                725     


<210> 17
<211> 517
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Val Pro Thr Glu Leu Ile Thr Lys Thr Leu Gln Leu Arg Val Ile 
1               5                   10                  15      


Arg Pro Leu Tyr Phe Glu Glu Ile Glu Lys Glu Leu Ala Glu Leu Lys 
            20                  25                  30          


Glu Gln Lys Glu Lys Glu Phe Glu Glu Thr Asn Ser Leu Leu Leu Glu 
        35                  40                  45              


Ser Lys Lys Ile Asp Ala Lys Ser Leu Lys Lys Leu Lys Arg Lys Ala 
    50                  55                  60                  


Arg Ser Ser Ala Ala Val Glu Phe Trp Lys Ile Ala Lys Glu Lys Tyr 
65                  70                  75                  80  


Pro Asp Ile Leu Thr Lys Pro Glu Met Glu Phe Ile Phe Ser Glu Met 
                85                  90                  95      


Gln Lys Met Met Ala Arg Phe Tyr Asn Lys Ser Met Thr Asn Ile Phe 
            100                 105                 110         


Ile Glu Met Asn Asn Asp Glu Lys Val Asn Pro Leu Ser Leu Ile Ser 
        115                 120                 125             


Lys Ala Ser Thr Glu Ala Asn Gln Val Ile Lys Cys Ser Ser Ile Ser 
    130                 135                 140                 


Ser Gly Leu Asn Arg Lys Ile Ala Gly Ser Ile Asn Lys Thr Lys Phe 
145                 150                 155                 160 


Lys Gln Val Arg Asp Gly Leu Ile Ser Leu Pro Thr Ala Arg Thr Glu 
                165                 170                 175     


Thr Phe Pro Ile Ser Phe Tyr Lys Ser Thr Ala Asn Lys Asp Glu Ile 
            180                 185                 190         


Pro Ile Ser Lys Ile Asn Leu Pro Ser Glu Glu Glu Ala Asp Leu Thr 
        195                 200                 205             


Ile Thr Leu Pro Phe Pro Phe Phe Glu Ile Lys Lys Glu Lys Lys Gly 
    210                 215                 220                 


Gln Lys Ala Tyr Ser Tyr Phe Asn Ile Ile Glu Lys Ser Gly Arg Ser 
225                 230                 235                 240 


Asn Asn Lys Ile Asp Leu Leu Leu Ser Thr His Arg Arg Gln Arg Arg 
                245                 250                 255     


Lys Gly Trp Lys Glu Glu Gly Gly Thr Ser Ala Glu Ile Arg Arg Leu 
            260                 265                 270         


Met Glu Gly Glu Phe Asp Lys Glu Trp Glu Ile Tyr Leu Gly Glu Ala 
        275                 280                 285             


Glu Lys Ser Glu Lys Ala Lys Asn Asp Leu Ile Lys Asn Met Thr Arg 
    290                 295                 300                 


Gly Lys Leu Ser Lys Asp Ile Lys Glu Gln Leu Glu Asp Ile Gln Val 
305                 310                 315                 320 


Lys Tyr Phe Ser Asp Asn Asn Val Glu Ser Trp Asn Asp Leu Ser Lys 
                325                 330                 335     


Glu Gln Lys Gln Glu Leu Ser Lys Leu Arg Lys Lys Lys Val Glu Glu 
            340                 345                 350         


Leu Lys Asp Trp Lys His Val Lys Glu Ile Leu Lys Thr Arg Ala Lys 
        355                 360                 365             


Ile Gly Trp Val Glu Leu Lys Arg Gly Lys Arg Gln Arg Asp Arg Asn 
    370                 375                 380                 


Lys Trp Phe Val Asn Ile Thr Ile Thr Arg Pro Pro Phe Ile Asn Lys 
385                 390                 395                 400 


Glu Leu Asp Asp Thr Lys Phe Gly Gly Ile Asp Leu Gly Val Lys Val 
                405                 410                 415     


Pro Phe Val Cys Ala Val His Gly Ser Pro Ala Arg Leu Ile Ile Lys 
            420                 425                 430         


Glu Asn Glu Ile Leu Gln Phe Asn Lys Met Val Ser Ala Arg Asn Arg 
        435                 440                 445             


Gln Ile Thr Lys Asp Ser Glu Gln Arg Lys Gly Arg Gly Lys Lys Asn 
    450                 455                 460                 


Lys Phe Ile Lys Lys Glu Ile Phe Asn Glu Arg Asn Glu Leu Phe Arg 
465                 470                 475                 480 


Lys Lys Ile Ile Glu Arg Trp Ala Asn Gln Ile Val Lys Phe Phe Glu 
                485                 490                 495     


Asp Gln Lys Cys Ala Thr Val Gln Ile Glu Asn Leu Glu Ser Phe Asp 
            500                 505                 510         


Arg Thr Ser Tyr Lys 
        515         


<210> 18
<211> 481
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Lys Ser Asp Thr Lys Asp Lys Lys Ile Ile Ile His Gln Thr Lys 
1               5                   10                  15      


Thr Leu Ser Leu Arg Ile Val Lys Pro Gln Ser Ile Pro Met Glu Glu 
            20                  25                  30          


Phe Thr Asp Leu Val Arg Tyr His Gln Met Ile Ile Phe Pro Val Tyr 
        35                  40                  45              


Asn Asn Gly Ala Ile Asp Leu Tyr Lys Lys Leu Phe Lys Ala Lys Ile 
    50                  55                  60                  


Gln Lys Gly Asn Glu Ala Arg Ala Ile Lys Tyr Phe Met Asn Lys Ile 
65                  70                  75                  80  


Val Tyr Ala Pro Ile Ala Asn Thr Val Lys Asn Ser Tyr Ile Ala Leu 
                85                  90                  95      


Gly Tyr Ser Thr Lys Met Gln Ser Ser Phe Ser Gly Lys Arg Leu Trp 
            100                 105                 110         


Asp Leu Arg Phe Gly Glu Ala Thr Pro Pro Thr Ile Lys Ala Asp Phe 
        115                 120                 125             


Pro Leu Pro Phe Tyr Asn Gln Ser Gly Phe Lys Val Ser Ser Glu Asn 
    130                 135                 140                 


Gly Glu Phe Ile Ile Gly Ile Pro Phe Gly Gln Tyr Thr Lys Lys Thr 
145                 150                 155                 160 


Val Ser Asp Ile Glu Lys Lys Thr Ser Phe Ala Trp Asp Lys Phe Thr 
                165                 170                 175     


Leu Glu Asp Thr Thr Lys Lys Thr Leu Ile Glu Leu Leu Leu Ser Thr 
            180                 185                 190         


Lys Thr Arg Lys Met Asn Glu Gly Trp Lys Asn Asn Glu Gly Thr Glu 
        195                 200                 205             


Ala Glu Ile Lys Arg Val Met Asp Gly Thr Tyr Gln Val Thr Ser Leu 
    210                 215                 220                 


Glu Ile Leu Gln Arg Asp Asp Ser Trp Phe Val Asn Phe Asn Ile Ala 
225                 230                 235                 240 


Tyr Asp Ser Leu Lys Lys Gln Pro Asp Arg Asp Lys Ile Ala Gly Ile 
                245                 250                 255     


His Met Gly Ile Thr Arg Pro Leu Thr Ala Val Ile Tyr Asn Asn Lys 
            260                 265                 270         


Tyr Arg Ala Leu Ser Ile Tyr Pro Asn Thr Val Met His Leu Thr Gln 
        275                 280                 285             


Lys Gln Leu Ala Arg Ile Lys Glu Gln Arg Thr Asn Ser Lys Tyr Ala 
    290                 295                 300                 


Thr Gly Gly His Gly Arg Asn Ala Lys Val Thr Gly Thr Asp Thr Leu 
305                 310                 315                 320 


Ser Glu Ala Tyr Arg Gln Arg Arg Lys Lys Ile Ile Glu Asp Trp Ile 
                325                 330                 335     


Ala Ser Ile Val Lys Phe Ala Ile Asn Asn Glu Ile Gly Thr Ile Tyr 
            340                 345                 350         


Leu Glu Asp Ile Ser Asn Thr Asn Ser Phe Phe Ala Ala Arg Glu Gln 
        355                 360                 365             


Lys Leu Ile Tyr Leu Glu Asp Ile Ser Asn Thr Asn Ser Phe Leu Ser 
    370                 375                 380                 


Thr Tyr Lys Tyr Pro Ile Ser Ala Ile Ser Asp Thr Leu Gln His Lys 
385                 390                 395                 400 


Leu Glu Glu Lys Ala Ile Gln Val Ile Arg Lys Lys Ala Tyr Tyr Val 
                405                 410                 415     


Asn Gln Ile Cys Ser Leu Cys Gly His Tyr Asn Lys Gly Phe Thr Tyr 
            420                 425                 430         


Gln Phe Arg Arg Lys Asn Lys Phe Pro Lys Met Lys Cys Gln Gly Cys 
        435                 440                 445             


Leu Glu Ala Thr Ser Thr Glu Phe Asn Ala Ala Ala Asn Val Ala Asn 
    450                 455                 460                 


Pro Asp Tyr Glu Lys Leu Leu Ile Lys His Gly Leu Leu Gln Leu Lys 
465                 470                 475                 480 


Lys 
    


<210> 19
<211> 358
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Ser Thr Ile Thr Arg Gln Val Arg Leu Ser Pro Thr Pro Glu Gln 
1               5                   10                  15      


Ser Arg Leu Leu Met Ala His Cys Gln Gln Tyr Ile Ser Thr Val Asn 
            20                  25                  30          


Val Leu Val Ala Ala Phe Asp Ser Glu Val Leu Thr Gly Lys Val Ser 
        35                  40                  45              


Thr Lys Asp Phe Arg Ala Ala Leu Pro Ser Ala Val Lys Asn Gln Ala 
    50                  55                  60                  


Leu Arg Asp Ala Gln Ser Val Phe Lys Arg Ser Val Glu Leu Gly Cys 
65                  70                  75                  80  


Leu Pro Val Leu Lys Lys Pro His Cys Gln Trp Asn Asn Gln Asn Trp 
                85                  90                  95      


Arg Val Glu Gly Asp Gln Leu Ile Leu Pro Ile Cys Lys Asp Gly Lys 
            100                 105                 110         


Thr Gln Gln Glu Arg Phe Arg Cys Ala Ala Val Ala Leu Glu Gly Lys 
        115                 120                 125             


Ala Gly Ile Leu Arg Ile Lys Lys Lys Arg Gly Lys Trp Ile Ala Asp 
    130                 135                 140                 


Leu Thr Val Thr Gln Glu Asp Ala Pro Glu Ser Ser Gly Ser Ala Ile 
145                 150                 155                 160 


Met Gly Val Asp Leu Gly Ile Lys Val Pro Ala Val Ala His Ile Gly 
                165                 170                 175     


Gly Lys Gly Thr Arg Phe Phe Gly Asn Gly Arg Ser Gln Arg Ser Met 
            180                 185                 190         


Arg Arg Arg Phe Tyr Ala Arg Arg Lys Thr Leu Gln Lys Ala Lys Lys 
        195                 200                 205             


Leu Arg Ala Val Arg Lys Ser Lys Gly Lys Glu Ala Arg Trp Met Lys 
    210                 215                 220                 


Thr Ile Asn His Gln Leu Ser Arg Gln Ile Val Asn His Ala His Ala 
225                 230                 235                 240 


Leu Gly Val Gly Thr Ile Lys Ile Glu Ala Leu Gln Gly Ile Arg Lys 
                245                 250                 255     


Gly Thr Thr Arg Lys Ser Arg Gly Ala Ala Ala Arg Lys Asn Asn Arg 
            260                 265                 270         


Met Thr Asn Thr Trp Ser Phe Ser Gln Leu Thr Leu Phe Ile Thr Tyr 
        275                 280                 285             


Lys Ala Gln Arg Gln Gly Ile Thr Val Glu Gln Val Asp Pro Ala Tyr 
    290                 295                 300                 


Thr Ser Gln Asp Cys Pro Ala Cys Arg Ala Arg Asn Gly Ala Gln Asp 
305                 310                 315                 320 


Arg Thr Tyr Val Cys Ser Glu Cys Gly Trp Arg Gly His Arg Asp Thr 
                325                 330                 335     


Val Gly Ala Ile Asn Ile Ser Arg Arg Ala Gly Leu Ser Gly His Arg 
            340                 345                 350         


Arg Gly Ala Thr Gly Ala 
        355             


<210> 20
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Ile Ala Gln Lys Thr Ile Lys Ile Lys Leu Asn Pro Thr Lys Glu 
1               5                   10                  15      


Gln Ile Ile Lys Leu Asn Ser Ile Ile Glu Glu Tyr Ile Lys Val Ser 
            20                  25                  30          


Asn Phe Thr Ala Lys Lys Ile Ala Glu Ile Gln Glu Ser Phe Thr Asp 
        35                  40                  45              


Ser Gly Leu Thr Gln Gly Thr Cys Ser Glu Cys Gly Lys Glu Lys Thr 
    50                  55                  60                  


Tyr Arg Lys Tyr His Leu Leu Lys Lys Asp Asn Lys Leu Phe Cys Ile 
65                  70                  75                  80  


Thr Cys Tyr Lys Arg Lys Tyr Ser Gln Phe Thr Leu Gln Lys Val Glu 
                85                  90                  95      


Phe Gln Asn Lys Thr Gly Leu Arg Asn Val Ala Lys Leu Pro Lys Thr 
            100                 105                 110         


Tyr Tyr Thr Asn Ala Ile Arg Phe Ala Ser Asp Thr Phe Ser Gly Phe 
        115                 120                 125             


Asp Glu Ile Ile Lys Lys Lys Gln Asn Arg Leu Asn Ser Ile Gln Asn 
    130                 135                 140                 


Arg Leu Asn Phe Trp Lys Glu Leu Leu Tyr Asn Pro Ser Asn Arg Asn 
145                 150                 155                 160 


Glu Ile Lys Ile Lys Val Val Lys Tyr Ala Pro Lys Thr Asp Thr Arg 
                165                 170                 175     


Glu His Pro His Tyr Tyr Ser Glu Ala Glu Ile Lys Gly Arg Ile Lys 
            180                 185                 190         


Arg Leu Glu Lys Gln Leu Lys Lys Phe Lys Met Pro Lys Tyr Pro Glu 
        195                 200                 205             


Phe Thr Ser Glu Thr Ile Ser Leu Gln Arg Glu Leu Tyr Ser Trp Lys 
    210                 215                 220                 


Asn Pro Asp Glu Leu Lys Ile Ser Ser Ile Thr Asp Lys Asn Glu Ser 
225                 230                 235                 240 


Met Asn Tyr Tyr Gly Lys Glu Tyr Leu Lys Arg Tyr Ile Asp Leu Ile 
                245                 250                 255     


Asn Ser Gln Thr Pro Gln Ile Leu Leu Glu Lys Glu Asn Asn Ser Phe 
            260                 265                 270         


Tyr Leu Cys Phe Pro Ile Thr Lys Asn Ile Glu Met Pro Lys Ile Asp 
        275                 280                 285             


Asp Thr Phe Glu Pro Val Gly Ile Asp Trp Gly Ile Thr Arg Asn Ile 
    290                 295                 300                 


Ala Val Val Ser Ile Leu Asp Ser Lys Thr Lys Lys Pro Lys Phe Val 
305                 310                 315                 320 


Lys Phe Tyr Ser Ala Gly Tyr Ile Leu Gly Lys Arg Lys His Tyr Lys 
                325                 330                 335     


Ser Leu Arg Lys His Phe Gly Gln Lys Lys Arg Gln Asp Lys Ile Asn 
            340                 345                 350         


Lys Leu Gly Thr Lys Glu Asp Arg Phe Ile Asp Ser Asn Ile His Lys 
        355                 360                 365             


Leu Ala Phe Leu Ile Val Lys Glu Ile Arg Asn His Ser Asn Lys Pro 
    370                 375                 380                 


Ile Ile Leu Met Glu Asn Ile Thr Asp Asn Arg Glu Glu Ala Glu Lys 
385                 390                 395                 400 


Ser Met Arg Gln Asn Ile Leu Leu His Ser Val Lys Ser Arg Leu Gln 
                405                 410                 415     


Asn Tyr Ile Ala Tyr Lys Ala Leu Trp Asn Asn Ile Pro Thr Asn Leu 
            420                 425                 430         


Val Lys Pro Glu His Thr Ser Gln Ile Cys Asn Arg Cys Gly His Gln 
        435                 440                 445             


Asp Arg Glu Asn Arg Pro Lys Gly Ser Lys Leu Phe Lys Cys Val Lys 
    450                 455                 460                 


Cys Asn Tyr Met Ser Asn Ala Asp Phe Asn Ala Ser Ile Asn Ile Ala 
465                 470                 475                 480 


Arg Lys Phe Tyr Ile Gly Glu Tyr Glu Pro Phe Tyr Lys Asp Asn Glu 
                485                 490                 495     


Lys Met Lys Ser Gly Val Asn Ser Ile Ser Met 
            500                 505         


<210> 21
<211> 534
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Leu Lys Leu Ser Glu Gln Glu Asn Ile Thr Thr Gly Val Lys Phe Lys 
1               5                   10                  15      


Leu Lys Leu Asp Lys Glu Thr Ser Glu Gly Leu Asn Asp Tyr Phe Asp 
            20                  25                  30          


Glu Tyr Gly Lys Ala Ile Asn Phe Ala Ile Lys Val Ile Gln Lys Glu 
        35                  40                  45              


Leu Ala Glu Asp Arg Phe Ala Gly Lys Val Arg Leu Asp Glu Asn Lys 
    50                  55                  60                  


Lys Pro Leu Leu Asn Glu Asp Gly Lys Lys Ile Trp Asp Phe Pro Asn 
65                  70                  75                  80  


Glu Phe Cys Ser Cys Gly Lys Gln Val Asn Arg Tyr Val Asn Gly Lys 
                85                  90                  95      


Ser Leu Cys Gln Glu Cys Tyr Lys Asn Lys Phe Thr Glu Tyr Gly Ile 
            100                 105                 110         


Arg Lys Arg Met Tyr Ser Ala Lys Gly Arg Lys Ala Glu Gln Asp Ile 
        115                 120                 125             


Asn Ile Lys Asn Ser Thr Asn Lys Ile Ser Lys Thr His Phe Asn Tyr 
    130                 135                 140                 


Ala Ile Arg Glu Ala Phe Ile Leu Asp Lys Ser Ile Lys Lys Gln Arg 
145                 150                 155                 160 


Lys Glu Arg Phe Arg Arg Leu Arg Glu Met Lys Lys Lys Leu Gln Glu 
                165                 170                 175     


Phe Ile Glu Ile Arg Asp Gly Asn Lys Ile Leu Cys Pro Lys Ile Glu 
            180                 185                 190         


Lys Gln Arg Val Glu Arg Tyr Ile His Pro Ser Trp Ile Asn Lys Glu 
        195                 200                 205             


Lys Lys Leu Glu Asp Phe Arg Gly Tyr Ser Met Ser Asn Val Leu Gly 
    210                 215                 220                 


Lys Ile Lys Ile Leu Asp Arg Asn Ile Lys Arg Glu Glu Lys Ser Leu 
225                 230                 235                 240 


Lys Glu Lys Gly Gln Ile Asn Phe Lys Ala Arg Arg Leu Met Leu Asp 
                245                 250                 255     


Lys Ser Val Lys Phe Leu Asn Asp Asn Lys Ile Ser Phe Thr Ile Ser 
            260                 265                 270         


Lys Asn Leu Pro Lys Glu Tyr Glu Leu Asp Leu Pro Glu Lys Glu Lys 
        275                 280                 285             


Arg Leu Asn Trp Leu Lys Glu Lys Ile Lys Ile Ile Lys Asn Gln Lys 
    290                 295                 300                 


Pro Lys Tyr Ala Tyr Leu Leu Arg Lys Asp Asp Asn Phe Tyr Leu Gln 
305                 310                 315                 320 


Tyr Thr Leu Glu Thr Glu Phe Asn Leu Lys Glu Asp Tyr Ser Gly Ile 
                325                 330                 335     


Val Gly Ile Asp Arg Gly Val Ser His Ile Ala Val Tyr Thr Phe Val 
            340                 345                 350         


His Asn Asn Gly Lys Asn Glu Arg Pro Leu Phe Leu Asn Ser Ser Glu 
        355                 360                 365             


Ile Leu Arg Leu Lys Asn Leu Gln Lys Glu Arg Asp Arg Phe Leu Arg 
    370                 375                 380                 


Arg Lys His Asn Lys Lys Arg Lys Lys Ser Asn Met Arg Asn Ile Glu 
385                 390                 395                 400 


Lys Lys Ile Gln Leu Ile Leu His Asn Tyr Ser Lys Gln Ile Val Asp 
                405                 410                 415     


Phe Ala Lys Asn Lys Asn Ala Phe Ile Val Phe Glu Lys Leu Glu Lys 
            420                 425                 430         


Pro Lys Lys Asn Arg Ser Lys Met Ser Lys Lys Ser Gln Tyr Lys Leu 
        435                 440                 445             


Ser Gln Phe Thr Phe Lys Lys Leu Ser Asp Leu Val Asp Tyr Lys Ala 
    450                 455                 460                 


Lys Arg Glu Gly Ile Lys Val Leu Tyr Ile Ser Pro Glu Tyr Thr Ser 
465                 470                 475                 480 


Lys Glu Cys Ser His Cys Gly Glu Lys Val Asn Thr Gln Arg Pro Phe 
                485                 490                 495     


Asn Gly Asn Ser Ser Leu Phe Lys Cys Asn Lys Cys Gly Val Glu Leu 
            500                 505                 510         


Asn Ala Asp Tyr Asn Ala Ser Ile Asn Ile Ala Lys Lys Gly Leu Asn 
        515                 520                 525             


Ile Leu Asn Ser Thr Asn 
    530                 


<210> 22
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Glu Glu Ser Ile Ile Thr Gly Val Lys Phe Lys Leu Arg Ile Asp 
1               5                   10                  15      


Lys Glu Thr Thr Lys Lys Leu Asn Glu Tyr Phe Asp Glu Tyr Gly Lys 
            20                  25                  30          


Ala Ile Asn Phe Ala Val Lys Ile Ile Gln Lys Glu Leu Ala Asp Asp 
        35                  40                  45              


Arg Phe Ala Gly Lys Ala Lys Leu Asp Gln Asn Lys Asn Pro Ile Leu 
    50                  55                  60                  


Asp Glu Asn Gly Lys Lys Ile Tyr Glu Phe Pro Asp Glu Phe Cys Ser 
65                  70                  75                  80  


Cys Gly Lys Gln Val Asn Lys Tyr Val Asn Asn Lys Pro Phe Cys Gln 
                85                  90                  95      


Glu Cys Tyr Lys Ile Arg Phe Thr Glu Asn Gly Ile Arg Lys Arg Met 
            100                 105                 110         


Tyr Ser Ala Lys Gly Arg Lys Ala Glu His Lys Ile Asn Ile Leu Asn 
        115                 120                 125             


Ser Thr Asn Lys Ile Ser Lys Thr His Phe Asn Tyr Ala Ile Arg Glu 
    130                 135                 140                 


Ala Phe Ile Leu Asp Lys Ser Ile Lys Lys Gln Arg Lys Lys Arg Asn 
145                 150                 155                 160 


Glu Arg Leu Arg Glu Ser Lys Lys Arg Leu Gln Gln Phe Ile Asp Met 
                165                 170                 175     


Arg Asp Gly Lys Arg Glu Ile Cys Pro Thr Ile Lys Gly Gln Lys Val 
            180                 185                 190         


Asp Arg Phe Ile His Pro Ser Trp Ile Thr Lys Asp Lys Lys Leu Glu 
        195                 200                 205             


Asp Phe Arg Gly Tyr Thr Leu Ser Ile Ile Asn Ser Lys Ile Lys Ile 
    210                 215                 220                 


Leu Asp Arg Asn Ile Lys Arg Glu Glu Lys Ser Leu Lys Glu Lys Gly 
225                 230                 235                 240 


Gln Ile Ile Phe Lys Ala Lys Arg Leu Met Leu Asp Lys Ser Ile Arg 
                245                 250                 255     


Phe Val Gly Asp Arg Lys Val Leu Phe Thr Ile Ser Lys Thr Leu Pro 
            260                 265                 270         


Lys Glu Tyr Glu Leu Asp Leu Pro Ser Lys Glu Lys Arg Leu Asn Trp 
        275                 280                 285             


Leu Lys Glu Lys Ile Glu Ile Ile Lys Asn Gln Lys Pro Lys Tyr Ala 
    290                 295                 300                 


Tyr Leu Leu Arg Lys Asn Ile Glu Ser Glu Lys Lys Pro Asn Tyr Glu 
305                 310                 315                 320 


Tyr Tyr Leu Gln Tyr Thr Leu Glu Ile Lys Pro Glu Leu Lys Asp Phe 
                325                 330                 335     


Tyr Asp Gly Ala Ile Gly Ile Asp Arg Gly Ile Asn His Ile Ala Val 
            340                 345                 350         


Cys Thr Phe Ile Ser Asn Asp Gly Lys Val Thr Pro Pro Lys Phe Phe 
        355                 360                 365             


Ser Ser Gly Glu Ile Leu Arg Leu Lys Asn Leu Gln Lys Glu Arg Asp 
    370                 375                 380                 


Arg Phe Leu Leu Arg Lys His Asn Lys Asn Arg Lys Lys Gly Asn Met 
385                 390                 395                 400 


Arg Val Ile Glu Asn Lys Ile Asn Leu Ile Leu His Arg Tyr Ser Lys 
                405                 410                 415     


Gln Ile Val Asp Met Ala Lys Lys Leu Asn Ala Ser Ile Val Phe Glu 
            420                 425                 430         


Glu Leu Gly Arg Ile Gly Lys Ser Arg Thr Lys Met Lys Lys Ser Gln 
        435                 440                 445             


Arg Tyr Lys Leu Ser Leu Phe Ile Phe Lys Lys Leu Ser Asp Leu Val 
    450                 455                 460                 


Asp Tyr Lys Ser Arg Arg Glu Gly Ile Arg Val Thr Tyr Val Pro Pro 
465                 470                 475                 480 


Glu Tyr Thr Ser Lys Glu Cys Ser His Cys Gly Glu Lys Val Asn Thr 
                485                 490                 495     


Gln Arg Pro Phe Asn Gly Asn Tyr Ser Leu Phe Lys Cys Asn Lys Cys 
            500                 505                 510         


Gly Ile Gln Leu Asn Ser Asp Tyr Asn Ala Ser Ile Asn Ile Ala Lys 
        515                 520                 525             


Lys Gly Leu Lys Ile Pro Asn Ser Thr 
    530                 535         


<210> 23
<211> 540
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Leu Trp Thr Ile Val Ile Gly Asp Phe Ile Glu Met Pro Lys Gln Asp 
1               5                   10                  15      


Leu Val Thr Thr Gly Ile Lys Phe Lys Leu Asp Val Asp Lys Glu Thr 
            20                  25                  30          


Arg Lys Lys Leu Asp Asp Tyr Phe Asp Glu Tyr Gly Lys Ala Ile Asn 
        35                  40                  45              


Phe Ala Val Lys Ile Ile Gln Lys Asn Leu Lys Glu Asp Arg Phe Ala 
    50                  55                  60                  


Gly Lys Ile Ala Leu Gly Glu Asp Lys Lys Pro Leu Leu Asp Lys Asp 
65                  70                  75                  80  


Gly Lys Lys Ile Tyr Asn Tyr Pro Asn Glu Ser Cys Ser Cys Gly Asn 
                85                  90                  95      


Gln Val Arg Arg Tyr Val Asn Ala Lys Pro Phe Cys Val Asp Cys Tyr 
            100                 105                 110         


Lys Leu Lys Phe Thr Glu Asn Gly Ile Arg Lys Arg Met Tyr Ser Ala 
        115                 120                 125             


Arg Gly Arg Lys Ala Asp Ser Asp Ile Asn Ile Lys Asn Ser Thr Asn 
    130                 135                 140                 


Lys Ile Ser Lys Thr His Phe Asn Tyr Ala Ile Arg Glu Gly Phe Ile 
145                 150                 155                 160 


Leu Asp Lys Ser Leu Lys Lys Gln Arg Ser Lys Arg Ile Lys Lys Leu 
                165                 170                 175     


Leu Glu Leu Lys Arg Lys Leu Gln Glu Phe Ile Asp Ile Arg Gln Gly 
            180                 185                 190         


Gln Met Val Leu Cys Pro Lys Ile Lys Asn Gln Arg Val Asp Lys Phe 
        195                 200                 205             


Ile His Pro Ser Trp Leu Lys Arg Asp Lys Lys Leu Glu Glu Phe Arg 
    210                 215                 220                 


Gly Tyr Ser Leu Ser Val Val Glu Gly Lys Ile Lys Ile Phe Asn Arg 
225                 230                 235                 240 


Asn Ile Leu Arg Glu Glu Asp Ser Leu Arg Gln Arg Gly His Val Asn 
                245                 250                 255     


Phe Lys Ala Asn Arg Ile Met Leu Asp Lys Ser Val Arg Phe Leu Asp 
            260                 265                 270         


Gly Gly Lys Val Asn Phe Asn Leu Asn Lys Gly Leu Pro Lys Glu Tyr 
        275                 280                 285             


Leu Leu Asp Leu Pro Lys Lys Glu Asn Lys Leu Ser Trp Leu Asn Glu 
    290                 295                 300                 


Lys Ile Ser Leu Ile Lys Leu Gln Lys Pro Lys Tyr Ala Tyr Leu Leu 
305                 310                 315                 320 


Arg Arg Glu Gly Ser Phe Phe Ile Gln Tyr Thr Ile Glu Asn Val Pro 
                325                 330                 335     


Lys Thr Phe Ser Asp Tyr Leu Gly Ala Ile Gly Ile Asp Arg Gly Ile 
            340                 345                 350         


Ser His Ile Ala Val Cys Thr Phe Val Ser Lys Asn Gly Val Asn Lys 
        355                 360                 365             


Ala Pro Val Phe Phe Ser Ser Gly Glu Ile Leu Lys Leu Lys Ser Leu 
    370                 375                 380                 


Gln Lys Gln Arg Asp Leu Phe Leu Arg Gly Lys His Asn Lys Ile Arg 
385                 390                 395                 400 


Lys Lys Ser Asn Met Arg Asn Ile Asp Asn Lys Ile Asn Leu Ile Leu 
                405                 410                 415     


His Lys Tyr Ser Arg Asn Ile Val Asn Leu Ala Lys Ser Glu Lys Ala 
            420                 425                 430         


Phe Ile Val Phe Glu Lys Leu Glu Lys Ile Lys Lys Ser Arg Phe Lys 
        435                 440                 445             


Met Ser Lys Ser Leu Gln Tyr Lys Leu Ser Gln Phe Thr Phe Lys Lys 
    450                 455                 460                 


Leu Ser Asp Leu Val Glu Tyr Lys Ala Lys Ile Glu Gly Ile Lys Val 
465                 470                 475                 480 


Asp Tyr Val Pro Pro Glu Tyr Thr Ser Lys Glu Cys Ser His Cys Gly 
                485                 490                 495     


Glu Lys Val Asp Thr Gln Arg Pro Phe Asn Gly Asn Ser Ser Leu Phe 
            500                 505                 510         


Lys Cys Asn Lys Cys Arg Val Gln Leu Asn Ala Asp Tyr Asn Ala Ser 
        515                 520                 525             


Ile Asn Ile Ala Lys Lys Ser Leu Asn Ile Ser Asn 
    530                 535                 540 


<210> 24
<211> 542
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Ser Lys Thr Thr Ile Ser Val Lys Leu Lys Ile Ile Asp Leu Ser 
1               5                   10                  15      


Ser Glu Lys Lys Glu Phe Leu Asp Asn Tyr Phe Asn Glu Tyr Ala Lys 
            20                  25                  30          


Ala Thr Thr Phe Cys Gln Leu Arg Ile Arg Arg Leu Leu Arg Asn Thr 
        35                  40                  45              


His Trp Leu Gly Lys Lys Glu Lys Ser Ser Lys Lys Trp Ile Phe Glu 
    50                  55                  60                  


Ser Gly Ile Cys Asp Leu Cys Gly Glu Asn Lys Glu Leu Val Asn Glu 
65                  70                  75                  80  


Asp Arg Asn Ser Gly Glu Pro Ala Lys Ile Cys Lys Arg Cys Tyr Asn 
                85                  90                  95      


Gly Arg Tyr Gly Asn Gln Met Ile Arg Lys Leu Phe Val Ser Thr Lys 
            100                 105                 110         


Lys Arg Glu Val Gln Glu Asn Met Asp Ile Arg Arg Val Ala Lys Leu 
        115                 120                 125             


Asn Asn Thr His Tyr His Arg Ile Pro Glu Glu Ala Phe Asp Met Ile 
    130                 135                 140                 


Lys Ala Ala Asp Thr Ala Glu Lys Arg Arg Lys Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Asp Lys Lys Arg Gln Met Glu Phe Ile Glu Met Phe Asn Asp Glu Lys 
                165                 170                 175     


Lys Arg Ala Ala Arg Pro Lys Lys Pro Asn Glu Arg Glu Thr Arg Tyr 
            180                 185                 190         


Val His Ile Ser Lys Leu Glu Ser Pro Ser Lys Gly Tyr Thr Leu Asn 
        195                 200                 205             


Gly Ile Lys Arg Lys Ile Asp Gly Met Gly Lys Lys Ile Glu Arg Ala 
    210                 215                 220                 


Glu Lys Gly Leu Ser Arg Lys Lys Ile Phe Gly Tyr Gln Gly Asn Arg 
225                 230                 235                 240 


Ile Lys Leu Asp Ser Asn Trp Val Arg Phe Asp Leu Ala Glu Ser Glu 
                245                 250                 255     


Ile Thr Ile Pro Ser Leu Phe Lys Glu Met Lys Leu Arg Ile Thr Gly 
            260                 265                 270         


Pro Thr Asn Val His Ser Lys Ser Gly Gln Ile Tyr Phe Ala Glu Trp 
        275                 280                 285             


Phe Glu Arg Ile Asn Lys Gln Pro Asn Asn Tyr Cys Tyr Leu Ile Arg 
    290                 295                 300                 


Lys Thr Ser Ser Asn Gly Lys Tyr Glu Tyr Tyr Leu Gln Tyr Thr Tyr 
305                 310                 315                 320 


Glu Ala Glu Val Glu Ala Asn Lys Glu Tyr Ala Gly Cys Leu Gly Val 
                325                 330                 335     


Asp Ile Gly Cys Ser Lys Leu Ala Ala Ala Val Tyr Tyr Asp Ser Lys 
            340                 345                 350         


Asn Lys Lys Ala Gln Lys Pro Ile Glu Ile Phe Thr Asn Pro Ile Lys 
        355                 360                 365             


Lys Ile Lys Met Arg Arg Glu Lys Leu Ile Lys Leu Leu Ser Arg Val 
    370                 375                 380                 


Lys Val Arg His Arg Arg Arg Lys Leu Met Gln Leu Ser Lys Thr Glu 
385                 390                 395                 400 


Pro Ile Ile Asp Tyr Thr Cys His Lys Thr Ala Arg Lys Ile Val Glu 
                405                 410                 415     


Met Ala Asn Thr Ala Lys Ala Phe Ile Ser Met Glu Asn Leu Glu Thr 
            420                 425                 430         


Gly Ile Lys Gln Lys Gln Gln Ala Arg Glu Thr Lys Lys Gln Lys Phe 
        435                 440                 445             


Tyr Arg Asn Met Phe Leu Phe Arg Lys Leu Ser Lys Leu Ile Glu Tyr 
    450                 455                 460                 


Lys Ala Leu Leu Lys Gly Ile Lys Ile Val Tyr Val Lys Pro Asp Tyr 
465                 470                 475                 480 


Thr Ser Gln Thr Cys Ser Ser Cys Gly Ala Asp Lys Glu Lys Thr Glu 
                485                 490                 495     


Arg Pro Ser Gln Ala Ile Phe Arg Cys Leu Asn Pro Thr Cys Arg Tyr 
            500                 505                 510         


Tyr Gln Arg Asp Ile Asn Ala Asp Phe Asn Ala Ala Val Asn Ile Ala 
        515                 520                 525             


Lys Lys Ala Leu Asn Asn Thr Glu Val Val Thr Thr Leu Leu 
    530                 535                 540         


<210> 25
<211> 564
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Ala Arg Ala Lys Asn Gln Pro Tyr Gln Lys Leu Thr Thr Thr Thr 
1               5                   10                  15      


Gly Ile Lys Phe Lys Leu Asp Leu Ser Glu Glu Glu Gly Lys Arg Phe 
            20                  25                  30          


Asp Glu Tyr Phe Ser Glu Tyr Ala Lys Ala Val Asn Phe Cys Ala Lys 
        35                  40                  45              


Val Ile Tyr Gln Leu Arg Lys Asn Leu Lys Phe Ala Gly Lys Lys Glu 
    50                  55                  60                  


Leu Ala Ala Lys Glu Trp Lys Phe Glu Ile Ser Asn Cys Asp Phe Cys 
65                  70                  75                  80  


Asn Lys Gln Lys Glu Ile Tyr Tyr Lys Asn Ile Ala Asn Gly Gln Lys 
                85                  90                  95      


Val Cys Lys Gly Cys His Arg Thr Asn Phe Ser Asp Asn Ala Ile Arg 
            100                 105                 110         


Lys Lys Met Ile Pro Val Lys Gly Arg Lys Val Glu Ser Lys Phe Asn 
        115                 120                 125             


Ile His Asn Thr Thr Lys Lys Ile Ser Gly Thr His Arg His Trp Ala 
    130                 135                 140                 


Phe Glu Asp Ala Ala Asp Ile Ile Glu Ser Met Asp Lys Gln Arg Lys 
145                 150                 155                 160 


Glu Lys Gln Lys Arg Leu Arg Arg Glu Lys Arg Lys Leu Ser Tyr Phe 
                165                 170                 175     


Phe Glu Leu Phe Gly Asp Pro Ala Lys Arg Tyr Glu Leu Pro Lys Val 
            180                 185                 190         


Gly Lys Gln Arg Val Pro Arg Tyr Leu His Lys Ile Ile Asp Lys Asp 
        195                 200                 205             


Ser Leu Thr Lys Lys Arg Gly Tyr Ser Leu Ser Tyr Ile Lys Asn Lys 
    210                 215                 220                 


Ile Lys Ile Ser Glu Arg Asn Ile Glu Arg Asp Glu Lys Ser Leu Arg 
225                 230                 235                 240 


Lys Ala Ser Pro Ile Ala Phe Gly Ala Arg Lys Ile Lys Met Ser Lys 
                245                 250                 255     


Leu Asp Pro Lys Arg Ala Phe Asp Leu Glu Asn Asn Val Phe Lys Ile 
            260                 265                 270         


Pro Gly Lys Val Ile Lys Gly Gln Tyr Lys Phe Phe Gly Thr Asn Val 
        275                 280                 285             


Ala Asn Glu His Gly Lys Lys Phe Tyr Lys Asp Arg Ile Ser Lys Ile 
    290                 295                 300                 


Leu Ala Gly Lys Pro Lys Tyr Phe Tyr Leu Leu Arg Lys Lys Val Ala 
305                 310                 315                 320 


Glu Ser Asp Gly Asn Pro Ile Phe Glu Tyr Tyr Val Gln Trp Ser Ile 
                325                 330                 335     


Asp Thr Glu Thr Pro Ala Ile Thr Ser Tyr Asp Asn Ile Leu Gly Ile 
            340                 345                 350         


Asp Ala Gly Ile Thr Asn Leu Ala Thr Thr Val Leu Ile Pro Lys Asn 
        355                 360                 365             


Leu Ser Ala Glu His Cys Ser His Cys Gly Asn Asn His Val Lys Pro 
    370                 375                 380                 


Ile Phe Thr Lys Phe Phe Ser Gly Lys Glu Leu Lys Ala Ile Lys Ile 
385                 390                 395                 400 


Lys Ser Arg Lys Gln Lys Tyr Phe Leu Arg Gly Lys His Asn Lys Leu 
                405                 410                 415     


Val Lys Ile Lys Arg Ile Arg Pro Ile Glu Gln Lys Val Asp Gly Tyr 
            420                 425                 430         


Cys His Val Val Ser Lys Gln Ile Val Glu Met Ala Lys Glu Arg Asn 
        435                 440                 445             


Ser Cys Ile Ala Leu Glu Lys Leu Glu Lys Pro Lys Lys Ser Lys Phe 
    450                 455                 460                 


Arg Gln Arg Arg Arg Glu Lys Tyr Ala Val Ser Met Phe Val Phe Lys 
465                 470                 475                 480 


Lys Leu Ala Thr Phe Ile Lys Tyr Lys Ala Ala Arg Glu Gly Ile Glu 
                485                 490                 495     


Ile Ile Pro Val Glu Pro Glu Gly Thr Ser Tyr Thr Cys Ser His Cys 
            500                 505                 510         


Lys Asn Ala Gln Asn Asn Gln Arg Pro Tyr Phe Lys Pro Asn Ser Lys 
        515                 520                 525             


Lys Ser Trp Thr Ser Met Phe Lys Cys Gly Lys Cys Gly Ile Glu Leu 
    530                 535                 540                 


Asn Ser Asp Tyr Asn Ala Ala Phe Asn Ile Ala Gln Lys Ala Leu Asn 
545                 550                 555                 560 


Met Thr Ser Ala 
                


<210> 26
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Asp Glu Lys His Phe Phe Cys Ser Tyr Cys Asn Lys Glu Leu Lys 
1               5                   10                  15      


Ile Ser Lys Asn Leu Ile Asn Lys Ile Ser Lys Gly Ser Ile Arg Glu 
            20                  25                  30          


Asp Glu Ala Val Ser Lys Ala Ile Ser Ile His Asn Lys Lys Glu His 
        35                  40                  45              


Ser Leu Ile Leu Gly Ile Lys Phe Lys Leu Phe Ile Glu Asn Lys Leu 
    50                  55                  60                  


Asp Lys Lys Lys Leu Asn Glu Tyr Phe Asp Asn Tyr Ser Lys Ala Val 
65                  70                  75                  80  


Thr Phe Ala Ala Arg Ile Phe Asp Lys Ile Arg Ser Pro Tyr Lys Phe 
                85                  90                  95      


Ile Gly Leu Lys Asp Lys Asn Thr Lys Lys Trp Thr Phe Pro Lys Ala 
            100                 105                 110         


Lys Cys Val Phe Cys Leu Glu Glu Lys Glu Val Ala Tyr Ala Asn Glu 
        115                 120                 125             


Lys Asp Asn Ser Lys Ile Cys Thr Glu Cys Tyr Leu Lys Glu Phe Gly 
    130                 135                 140                 


Glu Asn Gly Ile Arg Lys Lys Ile Tyr Ser Thr Arg Gly Arg Lys Val 
145                 150                 155                 160 


Glu Pro Lys Tyr Asn Ile Phe Asn Ser Thr Lys Glu Leu Ser Ser Thr 
                165                 170                 175     


His Tyr Asn Tyr Ala Ile Arg Asp Ala Phe Gln Leu Leu Asp Ala Leu 
            180                 185                 190         


Lys Lys Gln Arg Gln Lys Lys Leu Lys Ser Ile Phe Asn Gln Lys Leu 
        195                 200                 205             


Arg Leu Lys Glu Phe Glu Asp Ile Phe Ser Asp Pro Gln Lys Arg Ile 
    210                 215                 220                 


Glu Leu Ser Leu Lys Pro His Gln Arg Glu Lys Arg Tyr Ile His Leu 
225                 230                 235                 240 


Ser Lys Ser Gly Gln Glu Ser Ile Asn Arg Gly Tyr Thr Leu Arg Phe 
                245                 250                 255     


Val Arg Gly Lys Ile Lys Ser Leu Thr Arg Asn Ile Glu Arg Glu Glu 
            260                 265                 270         


Lys Ser Leu Arg Lys Lys Thr Pro Ile His Phe Lys Gly Asn Arg Leu 
        275                 280                 285             


Met Ile Phe Pro Ala Gly Ile Lys Phe Asp Phe Ala Ser Asn Lys Val 
    290                 295                 300                 


Lys Ile Ser Ile Ser Lys Asn Leu Pro Asn Glu Phe Asn Phe Ser Gly 
305                 310                 315                 320 


Thr Asn Val Lys Asn Glu His Gly Lys Ser Phe Phe Lys Ser Arg Ile 
                325                 330                 335     


Glu Leu Ile Lys Thr Gln Lys Pro Lys Tyr Ala Tyr Val Leu Arg Lys 
            340                 345                 350         


Ile Lys Arg Glu Tyr Ser Lys Leu Arg Asn Tyr Glu Ile Glu Lys Ile 
        355                 360                 365             


Arg Leu Glu Asn Pro Asn Ala Asp Leu Cys Asp Phe Tyr Leu Gln Tyr 
    370                 375                 380                 


Thr Ile Glu Thr Glu Ser Arg Asn Asn Glu Glu Ile Asn Gly Ile Ile 
385                 390                 395                 400 


Gly Ile Asp Arg Gly Ile Thr Asn Leu Ala Cys Leu Val Leu Leu Lys 
                405                 410                 415     


Lys Gly Asp Lys Lys Pro Ser Gly Val Lys Phe Tyr Lys Gly Asn Lys 
            420                 425                 430         


Ile Leu Gly Met Lys Ile Ala Tyr Arg Lys His Leu Tyr Leu Leu Lys 
        435                 440                 445             


Gly Lys Arg Asn Lys Leu Arg Lys Gln Arg Gln Ile Arg Ala Ile Glu 
    450                 455                 460                 


Pro Lys Ile Asn Leu Ile Leu His Gln Ile Ser Lys Asp Ile Val Lys 
465                 470                 475                 480 


Ile Ala Lys Glu Lys Asn Phe Ala Ile Ala Leu Glu Gln Leu Glu Lys 
                485                 490                 495     


Pro Lys Lys Ala Arg Phe Ala Gln Arg Lys Lys Glu Lys Tyr Lys Leu 
            500                 505                 510         


Ala Leu Phe Thr Phe Lys Asn Leu Ser Thr Leu Ile Glu Tyr Lys Ser 
        515                 520                 525             


Lys Arg Glu Gly Ile Pro Val Ile Tyr Val Pro Pro Glu Lys Thr Ser 
    530                 535                 540                 


Gln Met Cys Ser His Cys Ala Ile Asn Gly Asp Glu His Val Asp Thr 
545                 550                 555                 560 


Gln Arg Pro Tyr Lys Lys Pro Asn Ala Gln Lys Pro Ser Tyr Ser Leu 
                565                 570                 575     


Phe Lys Cys Asn Lys Cys Gly Ile Glu Leu Asn Ala Asp Tyr Asn Ala 
            580                 585                 590         


Ala Phe Asn Ile Ala Gln Lys Gly Leu Lys Thr Leu Met Leu Asn His 
        595                 600                 605             


Ser His 
    610 


<210> 27
<211> 369
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Leu Gln Thr Leu Leu Val Lys Leu Asp Pro Ser Lys Glu Gln Tyr 
1               5                   10                  15      


Lys Met Leu Tyr Glu Thr Met Glu Arg Phe Asn Glu Ala Cys Asn Gln 
            20                  25                  30          


Ile Ala Glu Thr Val Phe Ala Ile His Ser Ala Asn Lys Ile Glu Val 
        35                  40                  45              


Gln Lys Thr Val Tyr Tyr Pro Ile Arg Glu Lys Phe Gly Leu Ser Ala 
    50                  55                  60                  


Gln Leu Thr Ile Leu Ala Ile Arg Lys Val Cys Glu Ala Tyr Lys Arg 
65                  70                  75                  80  


Asp Lys Ser Ile Lys Pro Glu Phe Arg Leu Asp Gly Ala Leu Val Tyr 
                85                  90                  95      


Asp Gln Arg Val Leu Ser Trp Lys Gly Leu Asp Lys Val Ser Leu Val 
            100                 105                 110         


Thr Leu Gln Gly Arg Gln Ile Ile Pro Ile Lys Phe Gly Asp Tyr Gln 
        115                 120                 125             


Lys Ala Arg Met Asp Arg Ile Arg Gly Gln Ala Asp Leu Ile Leu Val 
    130                 135                 140                 


Lys Gly Val Phe Tyr Leu Cys Val Val Val Glu Val Ser Glu Glu Ser 
145                 150                 155                 160 


Pro Tyr Asp Pro Lys Gly Val Leu Gly Val Asp Leu Gly Ile Lys Asn 
                165                 170                 175     


Leu Ala Val Asp Ser Asp Gly Glu Val His Ser Gly Glu Gln Thr Thr 
            180                 185                 190         


Asn Thr Arg Glu Arg Leu Asp Ser Leu Lys Ala Arg Leu Gln Ser Lys 
        195                 200                 205             


Gly Thr Lys Ser Ala Lys Arg His Leu Lys Lys Leu Ser Gly Arg Met 
    210                 215                 220                 


Ala Lys Phe Ser Lys Asp Val Asn His Cys Ile Ser Lys Lys Leu Val 
225                 230                 235                 240 


Ala Lys Ala Lys Gly Thr Leu Met Ser Ile Ala Leu Glu Asp Leu Gln 
                245                 250                 255     


Gly Ile Arg Asp Arg Val Thr Val Arg Lys Ala Gln Arg Arg Asn Leu 
            260                 265                 270         


His Thr Trp Asn Phe Gly Leu Leu Arg Met Phe Val Asp Tyr Lys Ala 
        275                 280                 285             


Lys Ile Ala Gly Val Pro Leu Val Phe Val Asp Pro Arg Asn Thr Ser 
    290                 295                 300                 


Arg Thr Cys Pro Ser Cys Gly His Val Ala Lys Ala Asn Arg Pro Thr 
305                 310                 315                 320 


Arg Asp Glu Phe Arg Cys Val Ser Cys Gly Phe Ala Gly Ala Ala Asp 
                325                 330                 335     


His Ile Ala Ala Met Asn Ile Ala Phe Arg Ala Glu Val Ser Gln Pro 
            340                 345                 350         


Ile Val Thr Arg Phe Phe Val Gln Ser Gln Ala Pro Ser Phe Arg Val 
        355                 360                 365             


Gly 
    


<210> 28
<211> 552
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Asp Glu Glu Pro Asp Ser Ala Glu Pro Asn Leu Ala Pro Ile Ser 
1               5                   10                  15      


Val Lys Leu Lys Leu Val Lys Leu Asp Gly Glu Lys Leu Ala Ala Leu 
            20                  25                  30          


Asn Asp Tyr Phe Asn Glu Tyr Ala Lys Ala Val Asn Phe Cys Glu Leu 
        35                  40                  45              


Lys Met Gln Lys Ile Arg Lys Asn Leu Val Asn Ile Arg Gly Thr Tyr 
    50                  55                  60                  


Leu Lys Glu Lys Lys Ala Trp Ile Asn Gln Thr Gly Glu Cys Cys Ile 
65                  70                  75                  80  


Cys Lys Lys Ile Asp Glu Leu Arg Cys Glu Asp Lys Asn Pro Asp Ile 
                85                  90                  95      


Asn Gly Lys Ile Cys Lys Lys Cys Tyr Asn Gly Arg Tyr Gly Asn Gln 
            100                 105                 110         


Met Ile Arg Lys Leu Phe Val Ser Thr Asn Lys Arg Ala Val Pro Lys 
        115                 120                 125             


Ser Leu Asp Ile Arg Lys Val Ala Arg Leu His Asn Thr His Tyr His 
    130                 135                 140                 


Arg Ile Pro Pro Glu Ala Ala Asp Ile Ile Lys Ala Ile Glu Thr Ala 
145                 150                 155                 160 


Glu Arg Lys Arg Arg Asn Arg Ile Leu Phe Asp Glu Arg Arg Tyr Asn 
                165                 170                 175     


Glu Leu Lys Asp Ala Leu Glu Asn Glu Glu Lys Arg Val Ala Arg Pro 
            180                 185                 190         


Lys Lys Pro Lys Glu Arg Glu Val Arg Tyr Val Pro Ile Ser Lys Lys 
        195                 200                 205             


Asp Thr Pro Ser Lys Gly Tyr Thr Met Asn Ala Leu Val Arg Lys Val 
    210                 215                 220                 


Ser Gly Met Ala Lys Lys Ile Glu Arg Ala Lys Arg Asn Leu Asn Lys 
225                 230                 235                 240 


Arg Lys Lys Ile Glu Tyr Leu Gly Arg Arg Ile Leu Leu Asp Lys Asn 
                245                 250                 255     


Trp Val Arg Phe Asp Phe Asp Lys Ser Glu Ile Ser Ile Pro Thr Met 
            260                 265                 270         


Lys Glu Phe Phe Gly Glu Met Arg Phe Glu Ile Thr Gly Pro Ser Asn 
        275                 280                 285             


Val Met Ser Pro Asn Gly Arg Glu Tyr Phe Thr Lys Trp Phe Asp Arg 
    290                 295                 300                 


Ile Lys Ala Gln Pro Asp Asn Tyr Cys Tyr Leu Leu Arg Lys Glu Ser 
305                 310                 315                 320 


Glu Asp Glu Thr Asp Phe Tyr Leu Gln Tyr Thr Trp Arg Pro Asp Ala 
                325                 330                 335     


His Pro Lys Lys Asp Tyr Thr Gly Cys Leu Gly Ile Asp Ile Gly Gly 
            340                 345                 350         


Ser Lys Leu Ala Ser Ala Val Tyr Phe Asp Ala Asp Lys Asn Arg Ala 
        355                 360                 365             


Lys Gln Pro Ile Gln Ile Phe Ser Asn Pro Ile Gly Lys Trp Lys Thr 
    370                 375                 380                 


Lys Arg Gln Lys Val Ile Lys Val Leu Ser Lys Ala Ala Val Arg His 
385                 390                 395                 400 


Lys Thr Lys Lys Leu Glu Ser Leu Arg Asn Ile Glu Pro Arg Ile Asp 
                405                 410                 415     


Val His Cys His Arg Ile Ala Arg Lys Ile Val Gly Met Ala Leu Ala 
            420                 425                 430         


Ala Asn Ala Phe Ile Ser Met Glu Asn Leu Glu Gly Gly Ile Arg Glu 
        435                 440                 445             


Lys Gln Lys Ala Lys Glu Thr Lys Lys Gln Lys Phe Ser Arg Asn Met 
    450                 455                 460                 


Phe Val Phe Arg Lys Leu Ser Lys Leu Ile Glu Tyr Lys Ala Leu Met 
465                 470                 475                 480 


Glu Gly Val Lys Val Val Tyr Ile Val Pro Asp Tyr Thr Ser Gln Leu 
                485                 490                 495     


Cys Ser Ser Cys Gly Thr Asn Asn Thr Lys Arg Pro Lys Gln Ala Ile 
            500                 505                 510         


Phe Met Cys Gln Asn Thr Glu Cys Arg Tyr Phe Gly Lys Asn Ile Asn 
        515                 520                 525             


Ala Asp Phe Asn Ala Ala Ile Asn Ile Ala Lys Lys Ala Leu Asn Arg 
    530                 535                 540                 


Lys Asp Ile Val Arg Glu Leu Ser 
545                 550         


<210> 29
<211> 534
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Glu Lys Asn Asn Ser Glu Gln Thr Ser Ile Thr Thr Gly Ile Lys 
1               5                   10                  15      


Phe Lys Leu Lys Leu Asp Lys Glu Thr Lys Glu Lys Leu Asn Asn Tyr 
            20                  25                  30          


Phe Asp Glu Tyr Gly Lys Ala Ile Asn Phe Ala Val Arg Ile Ile Gln 
        35                  40                  45              


Met Gln Leu Asn Asp Asp Arg Leu Ala Gly Lys Tyr Lys Arg Asp Glu 
    50                  55                  60                  


Lys Gly Lys Pro Ile Leu Gly Glu Asp Gly Lys Lys Ile Leu Glu Ile 
65                  70                  75                  80  


Pro Asn Asp Phe Cys Ser Cys Gly Asn Gln Val Asn His Tyr Val Asn 
                85                  90                  95      


Gly Val Ser Phe Cys Gln Glu Cys Tyr Lys Lys Arg Phe Ser Glu Asn 
            100                 105                 110         


Gly Ile Arg Lys Arg Met Tyr Ser Ala Lys Gly Arg Lys Ala Glu Gln 
        115                 120                 125             


Asp Ile Asn Ile Lys Asn Ser Thr Asn Lys Ile Ser Lys Thr His Phe 
    130                 135                 140                 


Asn Tyr Ala Ile Arg Glu Ala Phe Asn Leu Asp Lys Ser Ile Lys Lys 
145                 150                 155                 160 


Gln Arg Glu Lys Arg Phe Lys Lys Leu Lys Asp Met Lys Arg Lys Leu 
                165                 170                 175     


Gln Glu Phe Leu Glu Ile Arg Asp Gly Lys Arg Val Ile Cys Pro Lys 
            180                 185                 190         


Ile Glu Lys Gln Lys Val Glu Arg Tyr Ile His Pro Ser Trp Ile Asn 
        195                 200                 205             


Lys Glu Lys Lys Leu Glu Glu Phe Arg Gly Tyr Ser Leu Ser Ile Val 
    210                 215                 220                 


Asn Ser Lys Ile Lys Ser Phe Asp Arg Asn Ile Gln Arg Glu Glu Lys 
225                 230                 235                 240 


Ser Leu Lys Glu Lys Gly Gln Ile Asn Phe Lys Ala Gln Arg Leu Met 
                245                 250                 255     


Leu Asp Lys Ser Val Lys Phe Leu Lys Asp Asn Lys Val Ser Phe Thr 
            260                 265                 270         


Ile Ser Lys Glu Leu Pro Lys Thr Phe Glu Leu Asp Leu Pro Lys Lys 
        275                 280                 285             


Glu Lys Lys Leu Asn Trp Leu Asn Glu Lys Leu Glu Ile Ile Lys Asn 
    290                 295                 300                 


Gln Lys Pro Lys Tyr Ala Tyr Leu Leu Arg Lys Glu Asn Asn Ile Phe 
305                 310                 315                 320 


Leu Gln Tyr Thr Leu Asp Ser Ile Pro Glu Ile His Ser Glu Tyr Ser 
                325                 330                 335     


Gly Ala Val Gly Ile Asp Arg Gly Val Ser His Ile Ala Val Tyr Thr 
            340                 345                 350         


Phe Leu Asp Lys Asp Gly Lys Asn Glu Arg Pro Phe Phe Leu Ser Ser 
        355                 360                 365             


Ser Gly Ile Leu Arg Leu Lys Asn Leu Gln Lys Glu Arg Asp Lys Phe 
    370                 375                 380                 


Leu Arg Lys Lys His Asn Lys Ile Arg Lys Lys Gly Asn Met Arg Asn 
385                 390                 395                 400 


Ile Glu Gln Lys Ile Asn Leu Ile Leu His Glu Tyr Ser Lys Gln Ile 
                405                 410                 415     


Val Asn Phe Ala Lys Asp Lys Asn Ala Phe Ile Val Phe Glu Leu Leu 
            420                 425                 430         


Glu Lys Pro Lys Lys Ser Arg Glu Arg Met Ser Lys Lys Ile Gln Tyr 
        435                 440                 445             


Lys Leu Ser Gln Phe Thr Phe Lys Lys Leu Ser Asp Leu Val Asp Tyr 
    450                 455                 460                 


Lys Ala Lys Arg Glu Gly Ile Lys Val Ile Tyr Val Glu Pro Ala Tyr 
465                 470                 475                 480 


Thr Ser Lys Asp Cys Ser His Cys Gly Glu Arg Val Asn Thr Gln Arg 
                485                 490                 495     


Pro Phe Asn Gly Asn Phe Ser Leu Phe Lys Cys Asn Lys Cys Gly Ile 
            500                 505                 510         


Val Leu Asn Ser Asp Tyr Asn Ala Ser Leu Asn Ile Ala Arg Lys Gly 
        515                 520                 525             


Leu Asn Ile Ser Ala Asn 
    530                 


<210> 30
<211> 577
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Ala Glu Glu Lys Phe Phe Phe Cys Glu Lys Cys Asn Lys Asp Ile 
1               5                   10                  15      


Lys Ile Pro Lys Asn Tyr Ile Asn Lys Gln Gly Ala Glu Glu Lys Ala 
            20                  25                  30          


Arg Ala Lys His Glu His Arg Val His Ala Leu Ile Leu Gly Ile Lys 
        35                  40                  45              


Phe Lys Ile Tyr Pro Lys Lys Glu Asp Ile Ser Lys Leu Asn Asp Tyr 
    50                  55                  60                  


Phe Asp Glu Tyr Ala Lys Ala Val Thr Phe Thr Ala Lys Ile Val Asp 
65                  70                  75                  80  


Lys Leu Lys Ala Pro Phe Leu Phe Ala Gly Lys Arg Asp Lys Asp Thr 
                85                  90                  95      


Ser Lys Lys Lys Trp Val Phe Pro Val Asp Lys Cys Ser Phe Cys Lys 
            100                 105                 110         


Glu Lys Thr Glu Ile Asn Tyr Arg Thr Lys Gln Gly Lys Asn Ile Cys 
        115                 120                 125             


Asn Ser Cys Tyr Leu Thr Glu Phe Gly Glu Gln Gly Leu Leu Glu Lys 
    130                 135                 140                 


Ile Tyr Ala Thr Lys Gly Arg Lys Val Ser Ser Ser Phe Asn Leu Phe 
145                 150                 155                 160 


Asn Ser Thr Lys Lys Leu Thr Gly Thr His Asn Asn Tyr Val Val Lys 
                165                 170                 175     


Glu Ser Leu Gln Leu Leu Asp Ala Leu Lys Lys Gln Arg Ser Lys Arg 
            180                 185                 190         


Leu Lys Lys Leu Ser Asn Thr Arg Arg Lys Leu Lys Gln Phe Glu Glu 
        195                 200                 205             


Met Phe Glu Lys Glu Asp Lys Arg Phe Gln Leu Pro Leu Lys Glu Lys 
    210                 215                 220                 


Gln Arg Glu Leu Arg Phe Ile His Val Ser Gln Lys Asp Arg Ala Thr 
225                 230                 235                 240 


Glu Phe Lys Gly Tyr Thr Met Asn Lys Ile Lys Ser Lys Ile Lys Val 
                245                 250                 255     


Leu Arg Arg Asn Ile Glu Arg Glu Gln Arg Ser Leu Asn Arg Lys Ser 
            260                 265                 270         


Pro Val Phe Phe Arg Gly Thr Arg Ile Arg Leu Ser Pro Ser Val Gln 
        275                 280                 285             


Phe Asp Asp Lys Asp Asn Lys Ile Lys Leu Thr Leu Ser Lys Glu Leu 
    290                 295                 300                 


Pro Lys Glu Tyr Ser Phe Ser Gly Leu Asn Val Ala Asn Glu His Gly 
305                 310                 315                 320 


Arg Lys Phe Phe Ala Glu Lys Leu Lys Leu Ile Lys Glu Asn Lys Ser 
                325                 330                 335     


Lys Tyr Ala Tyr Leu Leu Arg Arg Gln Val Asn Lys Asn Asn Lys Lys 
            340                 345                 350         


Pro Ile Tyr Asp Tyr Tyr Leu Gln Tyr Thr Val Glu Phe Leu Pro Asn 
        355                 360                 365             


Ile Ile Thr Asn Tyr Asn Gly Ile Leu Gly Ile Asp Arg Gly Ile Asn 
    370                 375                 380                 


Thr Leu Ala Cys Ile Val Leu Leu Glu Asn Lys Lys Glu Lys Pro Ser 
385                 390                 395                 400 


Phe Val Lys Phe Phe Ser Gly Lys Gly Ile Leu Asn Leu Lys Asn Lys 
                405                 410                 415     


Arg Arg Lys Gln Leu Tyr Phe Leu Lys Gly Val His Asn Lys Tyr Arg 
            420                 425                 430         


Lys Gln Gln Lys Ile Arg Pro Ile Glu Pro Arg Ile Asp Gln Ile Leu 
        435                 440                 445             


His Asp Ile Ser Lys Gln Ile Ile Asp Leu Ala Lys Glu Lys Arg Val 
    450                 455                 460                 


Ala Ile Ser Leu Glu Gln Leu Glu Lys Pro Gln Lys Pro Lys Phe Arg 
465                 470                 475                 480 


Gln Ser Arg Lys Ala Lys Tyr Lys Leu Ser Gln Phe Asn Phe Lys Thr 
                485                 490                 495     


Leu Ser Asn Tyr Ile Asp Tyr Lys Ala Lys Lys Glu Gly Ile Arg Val 
            500                 505                 510         


Ile Tyr Ile Ala Pro Glu Met Thr Ser Gln Asn Cys Ser Arg Cys Ala 
        515                 520                 525             


Met Lys Asn Asp Leu His Val Asn Thr Gln Arg Pro Tyr Lys Asn Thr 
    530                 535                 540                 


Ser Ser Leu Phe Lys Cys Asn Lys Cys Gly Val Glu Leu Asn Ala Asp 
545                 550                 555                 560 


Tyr Asn Ala Ala Phe Asn Ile Ala Gln Lys Gly Leu Lys Ile Leu Asn 
                565                 570                 575     


Ser 
    


<210> 31
<211> 613
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Ile Ser Leu Lys Leu Lys Leu Leu Pro Asp Glu Glu Gln Lys Lys 
1               5                   10                  15      


Leu Leu Asp Glu Met Phe Trp Lys Trp Ala Ser Ile Cys Thr Arg Val 
            20                  25                  30          


Gly Phe Gly Arg Ala Asp Lys Glu Asp Leu Lys Pro Pro Lys Asp Ala 
        35                  40                  45              


Glu Gly Val Trp Phe Ser Leu Thr Gln Leu Asn Gln Ala Asn Thr Asp 
    50                  55                  60                  


Ile Asn Asp Leu Arg Glu Ala Met Lys His Gln Lys His Arg Leu Glu 
65                  70                  75                  80  


Tyr Glu Lys Asn Arg Leu Glu Ala Gln Arg Asp Asp Thr Gln Asp Ala 
                85                  90                  95      


Leu Lys Asn Pro Asp Arg Arg Glu Ile Ser Thr Lys Arg Lys Asp Leu 
            100                 105                 110         


Phe Arg Pro Lys Ala Ser Val Glu Lys Gly Phe Leu Lys Leu Lys Tyr 
        115                 120                 125             


His Gln Glu Arg Tyr Trp Val Arg Arg Leu Lys Glu Ile Asn Lys Leu 
    130                 135                 140                 


Ile Glu Arg Lys Thr Lys Thr Leu Ile Lys Ile Glu Lys Gly Arg Ile 
145                 150                 155                 160 


Lys Phe Lys Ala Thr Arg Ile Thr Leu His Gln Gly Ser Phe Lys Ile 
                165                 170                 175     


Arg Phe Gly Asp Lys Pro Ala Phe Leu Ile Lys Ala Leu Ser Gly Lys 
            180                 185                 190         


Asn Gln Ile Asp Ala Pro Phe Val Val Val Pro Glu Gln Pro Ile Cys 
        195                 200                 205             


Gly Ser Val Val Asn Ser Lys Lys Tyr Leu Asp Glu Ile Thr Thr Asn 
    210                 215                 220                 


Phe Leu Ala Tyr Ser Val Asn Ala Met Leu Phe Gly Leu Ser Arg Ser 
225                 230                 235                 240 


Glu Glu Met Leu Leu Lys Ala Lys Arg Pro Glu Lys Ile Lys Lys Lys 
                245                 250                 255     


Glu Glu Lys Leu Ala Lys Lys Gln Ser Ala Phe Glu Asn Lys Lys Lys 
            260                 265                 270         


Glu Leu Gln Lys Leu Leu Gly Arg Glu Leu Thr Gln Gln Glu Glu Ala 
        275                 280                 285             


Ile Ile Glu Glu Thr Arg Asn Gln Phe Phe Gln Asp Phe Glu Val Lys 
    290                 295                 300                 


Ile Thr Lys Gln Tyr Ser Glu Leu Leu Ser Lys Ile Ala Asn Glu Leu 
305                 310                 315                 320 


Lys Gln Lys Asn Asp Phe Leu Lys Val Asn Lys Tyr Pro Ile Leu Leu 
                325                 330                 335     


Arg Lys Pro Leu Lys Lys Ala Lys Ser Lys Lys Ile Asn Asn Leu Ser 
            340                 345                 350         


Pro Ser Glu Trp Lys Tyr Tyr Leu Gln Phe Gly Val Lys Pro Leu Leu 
        355                 360                 365             


Lys Gln Lys Ser Arg Arg Lys Ser Arg Asn Val Leu Gly Ile Asp Arg 
    370                 375                 380                 


Gly Leu Lys His Leu Leu Ala Val Thr Val Leu Glu Pro Asp Lys Lys 
385                 390                 395                 400 


Thr Phe Val Trp Asn Lys Leu Tyr Pro Asn Pro Ile Thr Gly Trp Lys 
                405                 410                 415     


Trp Arg Arg Arg Lys Leu Leu Arg Ser Leu Lys Arg Leu Lys Arg Arg 
            420                 425                 430         


Ile Lys Ser Gln Lys His Glu Thr Ile His Glu Asn Gln Thr Arg Lys 
        435                 440                 445             


Lys Leu Lys Ser Leu Gln Gly Arg Ile Asp Asp Leu Leu His Asn Ile 
    450                 455                 460                 


Ser Arg Lys Ile Val Glu Thr Ala Lys Glu Tyr Asp Ala Val Ile Val 
465                 470                 475                 480 


Val Glu Asp Leu Gln Ser Met Arg Gln His Gly Arg Ser Lys Gly Asn 
                485                 490                 495     


Arg Leu Lys Thr Leu Asn Tyr Ala Leu Ser Leu Phe Asp Tyr Ala Asn 
            500                 505                 510         


Val Met Gln Leu Ile Lys Tyr Lys Ala Gly Ile Glu Gly Ile Gln Ile 
        515                 520                 525             


Tyr Asp Val Lys Pro Ala Gly Thr Ser Gln Asn Cys Ala Tyr Cys Leu 
    530                 535                 540                 


Leu Ala Gln Arg Asp Ser His Glu Tyr Lys Arg Ser Gln Glu Asn Ser 
545                 550                 555                 560 


Lys Ile Gly Val Cys Leu Asn Pro Asn Cys Gln Asn His Lys Lys Gln 
                565                 570                 575     


Ile Asp Ala Asp Leu Asn Ala Ala Arg Val Ile Ala Ser Cys Tyr Ala 
            580                 585                 590         


Leu Lys Ile Asn Asp Ser Gln Pro Phe Gly Thr Arg Lys Arg Phe Lys 
        595                 600                 605             


Lys Arg Thr Thr Asn 
    610             


<210> 32
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Glu Thr Leu Ser Leu Lys Leu Lys Leu Asn Pro Ser Lys Glu Gln 
1               5                   10                  15      


Leu Leu Val Leu Asp Lys Met Phe Trp Lys Trp Ala Ser Ile Cys Thr 
            20                  25                  30          


Arg Leu Gly Leu Lys Lys Ala Glu Met Ser Asp Leu Glu Pro Pro Lys 
        35                  40                  45              


Asp Ala Glu Gly Val Trp Phe Ser Lys Thr Gln Leu Asn Gln Ala Asn 
    50                  55                  60                  


Thr Asp Val Asn Asp Leu Arg Lys Ala Met Gln His Gln Gly Lys Arg 
65                  70                  75                  80  


Ile Glu Tyr Glu Leu Asp Lys Val Glu Asn Arg Arg Asn Glu Ile Gln 
                85                  90                  95      


Glu Met Leu Glu Lys Pro Asp Arg Arg Asp Ile Ser Pro Asn Arg Lys 
            100                 105                 110         


Asp Leu Phe Arg Pro Lys Ala Ala Val Glu Lys Gly Tyr Leu Lys Leu 
        115                 120                 125             


Lys Tyr His Lys Leu Gly Tyr Trp Ser Lys Glu Leu Lys Thr Ala Asn 
    130                 135                 140                 


Lys Leu Ile Glu Arg Lys Arg Lys Thr Leu Ala Lys Ile Asp Ala Gly 
145                 150                 155                 160 


Lys Met Lys Phe Lys Pro Thr Arg Ile Ser Leu His Thr Asn Ser Phe 
                165                 170                 175     


Arg Ile Lys Phe Gly Glu Glu Pro Lys Ile Ala Leu Ser Thr Thr Ser 
            180                 185                 190         


Lys His Glu Lys Ile Glu Leu Pro Leu Ile Thr Ser Leu Gln Arg Pro 
        195                 200                 205             


Leu Lys Thr Ser Cys Ala Lys Lys Ser Lys Thr Tyr Leu Asp Ala Ala 
    210                 215                 220                 


Ile Leu Asn Phe Leu Ala Tyr Ser Thr Asn Ala Ala Leu Phe Gly Leu 
225                 230                 235                 240 


Ser Arg Ser Glu Glu Met Leu Leu Lys Ala Lys Lys Pro Glu Lys Ile 
                245                 250                 255     


Glu Lys Arg Asp Arg Lys Leu Ala Thr Lys Arg Glu Ser Phe Asp Lys 
            260                 265                 270         


Lys Leu Lys Thr Leu Glu Lys Leu Leu Glu Arg Lys Leu Ser Glu Lys 
        275                 280                 285             


Glu Lys Ser Val Phe Lys Arg Lys Gln Thr Glu Phe Phe Asp Lys Phe 
    290                 295                 300                 


Cys Ile Thr Leu Asp Glu Thr Tyr Val Glu Ala Leu His Arg Ile Ala 
305                 310                 315                 320 


Glu Glu Leu Val Ser Lys Asn Lys Tyr Leu Glu Ile Lys Lys Tyr Pro 
                325                 330                 335     


Val Leu Leu Arg Lys Pro Glu Ser Arg Leu Arg Ser Lys Lys Leu Lys 
            340                 345                 350         


Asn Leu Lys Pro Glu Asp Trp Thr Tyr Tyr Ile Gln Phe Gly Phe Gln 
        355                 360                 365             


Pro Leu Leu Asp Thr Pro Lys Pro Ile Lys Thr Lys Thr Val Leu Gly 
    370                 375                 380                 


Ile Asp Arg Gly Val Arg His Leu Leu Ala Val Ser Ile Phe Asp Pro 
385                 390                 395                 400 


Arg Thr Lys Thr Phe Thr Phe Asn Arg Leu Tyr Ser Asn Pro Ile Val 
                405                 410                 415     


Asp Trp Lys Trp Arg Arg Arg Lys Leu Leu Arg Ser Ile Lys Arg Leu 
            420                 425                 430         


Lys Arg Arg Leu Lys Ser Glu Lys His Val His Leu His Glu Asn Gln 
        435                 440                 445             


Phe Lys Ala Lys Leu Arg Ser Leu Glu Gly Arg Ile Glu Asp His Phe 
    450                 455                 460                 


His Asn Leu Ser Lys Glu Ile Val Asp Leu Ala Lys Glu Asn Asn Ser 
465                 470                 475                 480 


Val Ile Val Val Glu Asn Leu Gly Gly Met Arg Gln His Gly Arg Gly 
                485                 490                 495     


Arg Gly Lys Trp Leu Lys Ala Leu Asn Tyr Ala Leu Ser His Phe Asp 
            500                 505                 510         


Tyr Ala Lys Val Met Gln Leu Ile Lys Tyr Lys Ala Glu Leu Ala Gly 
        515                 520                 525             


Val Phe Val Tyr Asp Val Ala Pro Ala Gly Thr Ser Ile Asn Cys Ala 
    530                 535                 540                 


Tyr Cys Leu Leu Asn Asp Lys Asp Ala Ser Asn Tyr Thr Arg Gly Lys 
545                 550                 555                 560 


Val Ile Asn Gly Lys Lys Asn Thr Lys Ile Gly Glu Cys Lys Thr Cys 
                565                 570                 575     


Lys Lys Glu Phe Asp Ala Asp Leu Asn Ala Ala Arg Val Ile Ala Leu 
            580                 585                 590         


Cys Tyr Glu Lys Arg Leu Asn Asp Pro Gln Pro Phe Gly Thr Arg Lys 
        595                 600                 605             


Gln Phe Lys Pro Lys Lys Pro 
    610                 615 


<210> 33
<211> 775
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Lys Ala Leu Lys Leu Gln Leu Ile Pro Thr Arg Lys Gln Tyr Lys 
1               5                   10                  15      


Ile Leu Asp Glu Met Phe Trp Lys Trp Ala Ser Leu Ala Asn Arg Val 
            20                  25                  30          


Ser Gln Lys Gly Glu Ser Lys Glu Thr Leu Ala Pro Lys Lys Asp Ile 
        35                  40                  45              


Gln Lys Ile Gln Phe Asn Ala Thr Gln Leu Asn Gln Ile Glu Lys Asp 
    50                  55                  60                  


Ile Lys Asp Leu Arg Gly Ala Met Lys Glu Gln Gln Lys Gln Lys Glu 
65                  70                  75                  80  


Arg Leu Leu Leu Gln Ile Gln Glu Arg Arg Ser Thr Ile Ser Glu Met 
                85                  90                  95      


Leu Asn Asp Asp Asn Asn Lys Glu Arg Asp Pro His Arg Pro Leu Asn 
            100                 105                 110         


Phe Arg Pro Lys Gly Trp Arg Lys Phe His Thr Ser Lys His Trp Val 
        115                 120                 125             


Gly Glu Leu Ser Lys Ile Leu Arg Gln Glu Asp Arg Val Lys Lys Thr 
    130                 135                 140                 


Ile Glu Arg Ile Val Ala Gly Lys Ile Ser Phe Lys Pro Lys Arg Ile 
145                 150                 155                 160 


Gly Ile Trp Ser Ser Asn Tyr Lys Ile Asn Phe Phe Lys Arg Lys Ile 
                165                 170                 175     


Ser Ile Asn Pro Leu Asn Ser Lys Gly Phe Glu Leu Thr Leu Met Thr 
            180                 185                 190         


Glu Pro Thr Gln Asp Leu Ile Gly Lys Asn Gly Gly Lys Ser Val Leu 
        195                 200                 205             


Asn Asn Lys Arg Tyr Leu Asp Asp Ser Ile Lys Ser Leu Leu Met Phe 
    210                 215                 220                 


Ala Leu His Ser Arg Phe Phe Gly Leu Asn Asn Thr Asp Thr Tyr Leu 
225                 230                 235                 240 


Leu Gly Gly Lys Ile Asn Pro Ser Leu Val Lys Tyr Tyr Lys Lys Asn 
                245                 250                 255     


Gln Asp Met Gly Glu Phe Gly Arg Glu Ile Val Glu Lys Phe Glu Arg 
            260                 265                 270         


Lys Leu Lys Gln Glu Ile Asn Glu Gln Gln Lys Lys Ile Ile Met Ser 
        275                 280                 285             


Gln Ile Lys Glu Gln Tyr Ser Asn Arg Asp Ser Ala Phe Asn Lys Asp 
    290                 295                 300                 


Tyr Leu Gly Leu Ile Asn Glu Phe Ser Glu Val Phe Asn Gln Arg Lys 
305                 310                 315                 320 


Ser Glu Arg Ala Glu Tyr Leu Leu Asp Ser Phe Glu Asp Lys Ile Lys 
                325                 330                 335     


Gln Ile Lys Gln Glu Ile Gly Glu Ser Leu Asn Ile Ser Asp Trp Asp 
            340                 345                 350         


Phe Leu Ile Asp Glu Ala Lys Lys Ala Tyr Gly Tyr Glu Glu Gly Phe 
        355                 360                 365             


Thr Glu Tyr Val Tyr Ser Lys Arg Tyr Leu Glu Ile Leu Asn Lys Ile 
    370                 375                 380                 


Val Lys Ala Val Leu Ile Thr Asp Ile Tyr Phe Asp Leu Arg Lys Tyr 
385                 390                 395                 400 


Pro Ile Leu Leu Arg Lys Pro Leu Asp Lys Ile Lys Lys Ile Ser Asn 
                405                 410                 415     


Leu Lys Pro Asp Glu Trp Ser Tyr Tyr Ile Gln Phe Gly Tyr Asp Ser 
            420                 425                 430         


Ile Asn Pro Val Gln Leu Met Ser Thr Asp Lys Phe Leu Gly Ile Asp 
        435                 440                 445             


Arg Gly Leu Thr His Leu Leu Ala Tyr Ser Val Phe Asp Lys Glu Lys 
    450                 455                 460                 


Lys Glu Phe Ile Ile Asn Gln Leu Glu Pro Asn Pro Ile Met Gly Trp 
465                 470                 475                 480 


Lys Trp Lys Leu Arg Lys Val Lys Arg Ser Leu Gln His Leu Glu Arg 
                485                 490                 495     


Arg Ile Arg Ala Gln Lys Met Val Lys Leu Pro Glu Asn Gln Met Lys 
            500                 505                 510         


Lys Lys Leu Lys Ser Ile Glu Pro Lys Ile Glu Val His Tyr His Asn 
        515                 520                 525             


Ile Ser Arg Lys Ile Val Asn Leu Ala Lys Asp Tyr Asn Ala Ser Ile 
    530                 535                 540                 


Val Val Glu Ser Leu Glu Gly Gly Gly Leu Lys Gln His Gly Arg Lys 
545                 550                 555                 560 


Lys Asn Ala Arg Asn Arg Ser Leu Asn Tyr Ala Leu Ser Leu Phe Asp 
                565                 570                 575     


Tyr Gly Lys Ile Ala Ser Leu Ile Lys Tyr Lys Ala Asp Leu Glu Gly 
            580                 585                 590         


Val Pro Met Tyr Glu Val Leu Pro Ala Tyr Thr Ser Gln Gln Cys Ala 
        595                 600                 605             


Lys Cys Val Leu Glu Lys Gly Ser Phe Val Asp Pro Glu Ile Ile Gly 
    610                 615                 620                 


Tyr Val Glu Asp Ile Gly Ile Lys Gly Ser Leu Leu Asp Ser Leu Phe 
625                 630                 635                 640 


Glu Gly Thr Glu Leu Ser Ser Ile Gln Val Leu Lys Lys Ile Lys Asn 
                645                 650                 655     


Lys Ile Glu Leu Ser Ala Arg Asp Asn His Asn Lys Glu Ile Asn Leu 
            660                 665                 670         


Ile Leu Lys Tyr Asn Phe Lys Gly Leu Val Ile Val Arg Gly Gln Asp 
        675                 680                 685             


Lys Glu Glu Ile Ala Glu His Pro Ile Lys Glu Ile Asn Gly Lys Phe 
    690                 695                 700                 


Ala Ile Leu Asp Phe Val Tyr Lys Arg Gly Lys Glu Lys Val Gly Lys 
705                 710                 715                 720 


Lys Gly Asn Gln Lys Val Arg Tyr Thr Gly Asn Lys Lys Val Gly Tyr 
                725                 730                 735     


Cys Ser Lys His Gly Gln Val Asp Ala Asp Leu Asn Ala Ser Arg Val 
            740                 745                 750         


Ile Ala Leu Cys Lys Tyr Leu Asp Ile Asn Asp Pro Ile Leu Phe Gly 
        755                 760                 765             


Glu Gln Arg Lys Ser Phe Lys 
    770                 775 


<210> 34
<211> 777
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Val Thr Arg Ala Ile Lys Leu Lys Leu Asp Pro Thr Lys Asn Gln 
1               5                   10                  15      


Tyr Lys Leu Leu Asn Glu Met Phe Trp Lys Trp Ala Ser Leu Ala Asn 
            20                  25                  30          


Arg Phe Ser Gln Lys Gly Ala Ser Lys Glu Thr Leu Ala Pro Lys Asp 
        35                  40                  45              


Gly Thr Gln Lys Ile Gln Phe Asn Ala Thr Gln Leu Asn Gln Ile Lys 
    50                  55                  60                  


Lys Asp Val Asp Asp Leu Arg Gly Ala Met Glu Lys Gln Gly Lys Gln 
65                  70                  75                  80  


Lys Glu Arg Leu Leu Ile Gln Ile Gln Glu Arg Leu Leu Thr Ile Ser 
                85                  90                  95      


Glu Ile Leu Arg Asp Asp Ser Lys Lys Glu Lys Asp Pro His Arg Pro 
            100                 105                 110         


Gln Asn Phe Arg Pro Phe Gly Trp Arg Arg Phe His Thr Ser Ala Tyr 
        115                 120                 125             


Trp Ser Ser Glu Ala Ser Lys Leu Thr Arg Gln Val Asp Arg Val Arg 
    130                 135                 140                 


Arg Thr Ile Glu Arg Ile Lys Ala Gly Lys Ile Asn Phe Lys Pro Lys 
145                 150                 155                 160 


Arg Ile Gly Leu Trp Ser Ser Thr Tyr Lys Ile Asn Phe Leu Lys Lys 
                165                 170                 175     


Lys Ile Asn Ile Ser Pro Leu Lys Ser Lys Ser Phe Glu Leu Asp Leu 
            180                 185                 190         


Ile Thr Glu Pro Gln Gln Lys Ile Ile Gly Lys Glu Gly Gly Lys Ser 
        195                 200                 205             


Val Ala Asn Ser Lys Lys Tyr Leu Asp Asp Ser Ile Lys Ser Leu Leu 
    210                 215                 220                 


Ile Phe Ala Ile Lys Ser Arg Leu Phe Gly Leu Asn Asn Lys Asp Lys 
225                 230                 235                 240 


Pro Leu Phe Glu Asn Ile Ile Thr Pro Asn Leu Val Arg Tyr His Lys 
                245                 250                 255     


Lys Gly Gln Glu Gln Glu Asn Phe Lys Lys Glu Val Ile Lys Lys Phe 
            260                 265                 270         


Glu Asn Lys Leu Lys Lys Glu Ile Ser Gln Lys Gln Lys Glu Ile Ile 
        275                 280                 285             


Phe Ser Gln Ile Glu Arg Gln Tyr Glu Asn Arg Asp Ala Thr Phe Ser 
    290                 295                 300                 


Glu Asp Tyr Leu Arg Ala Ile Ser Glu Phe Ser Glu Ile Phe Asn Gln 
305                 310                 315                 320 


Arg Lys Lys Glu Arg Ala Lys Glu Leu Leu Asn Ser Phe Asn Glu Lys 
                325                 330                 335     


Ile Arg Gln Leu Lys Lys Glu Val Asn Gly Asn Ile Ser Glu Glu Asp 
            340                 345                 350         


Leu Lys Ile Leu Glu Val Glu Ala Glu Lys Ala Tyr Asn Tyr Glu Asn 
        355                 360                 365             


Gly Phe Ile Glu Trp Glu Tyr Ser Glu Gln Phe Leu Gly Val Leu Glu 
    370                 375                 380                 


Lys Ile Ala Arg Ala Val Leu Ile Ser Asp Asn Tyr Phe Asp Leu Lys 
385                 390                 395                 400 


Lys Tyr Pro Ile Leu Ile Arg Lys Pro Thr Asn Lys Ser Lys Lys Ile 
                405                 410                 415     


Thr Asn Leu Lys Pro Glu Glu Trp Asp Tyr Tyr Ile Gln Phe Gly Tyr 
            420                 425                 430         


Gly Leu Ile Asn Ser Pro Met Lys Ile Glu Thr Lys Asn Phe Met Gly 
        435                 440                 445             


Ile Asp Arg Gly Leu Thr His Leu Leu Ala Tyr Ser Ile Phe Asp Arg 
    450                 455                 460                 


Asp Ser Glu Lys Phe Thr Ile Asn Gln Leu Glu Leu Asn Pro Ile Lys 
465                 470                 475                 480 


Gly Trp Lys Trp Lys Leu Arg Lys Val Lys Arg Ser Leu Gln His Leu 
                485                 490                 495     


Glu Arg Arg Met Arg Ala Gln Lys Gly Val Lys Leu Pro Glu Asn Gln 
            500                 505                 510         


Met Lys Lys Arg Leu Lys Ser Ile Glu Pro Lys Ile Glu Ser Tyr Tyr 
        515                 520                 525             


His Asn Leu Ser Arg Lys Ile Val Asn Leu Ala Lys Ala Asn Asn Ala 
    530                 535                 540                 


Ser Ile Val Val Glu Ser Leu Glu Gly Gly Gly Leu Lys Gln His Gly 
545                 550                 555                 560 


Arg Lys Lys Asn Ser Arg His Arg Ala Leu Asn Tyr Ala Leu Ser Leu 
                565                 570                 575     


Phe Asp Tyr Gly Lys Ile Ala Ser Leu Ile Lys Tyr Lys Ser Asp Leu 
            580                 585                 590         


Glu Gly Val Pro Met Tyr Glu Val Leu Pro Ala Tyr Thr Ser Gln Gln 
        595                 600                 605             


Cys Ala Lys Cys Val Leu Lys Lys Gly Ser Phe Val Glu Pro Glu Ile 
    610                 615                 620                 


Ile Gly Tyr Ile Glu Glu Ile Gly Phe Lys Glu Asn Leu Leu Thr Leu 
625                 630                 635                 640 


Leu Phe Glu Asp Thr Gly Leu Ser Ser Val Gln Val Leu Lys Lys Ser 
                645                 650                 655     


Lys Asn Lys Met Thr Leu Ser Ala Arg Asp Lys Glu Gly Lys Met Val 
            660                 665                 670         


Asp Leu Val Leu Lys Tyr Asn Phe Lys Gly Leu Val Ile Ser Gln Glu 
        675                 680                 685             


Lys Lys Lys Glu Glu Ile Val Glu Phe Pro Ile Lys Glu Ile Asp Gly 
    690                 695                 700                 


Lys Phe Ala Val Leu Asp Ser Ala Tyr Lys Arg Gly Lys Glu Arg Ile 
705                 710                 715                 720 


Ser Lys Lys Gly Asn Gln Lys Leu Val Tyr Thr Gly Asn Lys Lys Val 
                725                 730                 735     


Gly Tyr Cys Ser Val His Gly Gln Val Asp Ala Asp Leu Asn Ala Ser 
            740                 745                 750         


Arg Val Ile Ala Leu Cys Lys Tyr Leu Gly Ile Asn Glu Pro Ile Val 
        755                 760                 765             


Phe Gly Glu Gln Arg Lys Ser Phe Lys 
    770                 775         


<210> 35
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Leu Asp Leu Ile Thr Glu Pro Ile Gln Pro His Lys Ser Ser Ser Leu 
1               5                   10                  15      


Arg Ser Lys Glu Phe Leu Glu Tyr Gln Ile Ser Asp Phe Leu Asn Phe 
            20                  25                  30          


Ser Leu His Ser Leu Phe Phe Gly Leu Ala Ser Asn Glu Gly Pro Leu 
        35                  40                  45              


Val Asp Phe Lys Ile Tyr Asp Lys Ile Val Ile Pro Lys Pro Glu Glu 
    50                  55                  60                  


Arg Phe Pro Lys Lys Glu Ser Glu Glu Gly Lys Lys Leu Asp Ser Phe 
65                  70                  75                  80  


Asp Lys Arg Val Glu Glu Tyr Tyr Ser Asp Lys Leu Glu Lys Lys Ile 
                85                  90                  95      


Glu Arg Lys Leu Asn Thr Glu Glu Lys Asn Val Ile Asp Arg Glu Lys 
            100                 105                 110         


Thr Arg Ile Trp Gly Glu Val Asn Lys Leu Glu Glu Ile Arg Ser Ile 
        115                 120                 125             


Ile Asp Glu Ile Asn Glu Ile Lys Lys Gln Lys His Ile Ser Glu Lys 
    130                 135                 140                 


Ser Lys Leu Leu Gly Glu Lys Trp Lys Lys Val Asn Asn Ile Gln Glu 
145                 150                 155                 160 


Thr Leu Leu Ser Gln Glu Tyr Val Ser Leu Ile Ser Asn Leu Ser Asp 
                165                 170                 175     


Glu Leu Thr Asn Lys Lys Lys Glu Leu Leu Ala Lys Lys Tyr Ser Lys 
            180                 185                 190         


Phe Asp Asp Lys Ile Lys Lys Ile Lys Glu Asp Tyr Gly Leu Glu Phe 
        195                 200                 205             


Asp Glu Asn Thr Ile Lys Lys Glu Gly Glu Lys Ala Phe Leu Asn Pro 
    210                 215                 220                 


Asp Lys Phe Ser Lys Tyr Gln Phe Ser Ser Ser Tyr Leu Lys Leu Ile 
225                 230                 235                 240 


Gly Glu Ile Ala Arg Ser Leu Ile Thr Tyr Lys Gly Phe Leu Asp Leu 
                245                 250                 255     


Asn Lys Tyr Pro Ile Ile Phe Arg Lys Pro Ile Asn Lys Val Lys Lys 
            260                 265                 270         


Ile His Asn Leu Glu Pro Asp Glu Trp Lys Tyr Tyr Ile Gln Phe Gly 
        275                 280                 285             


Tyr Glu Gln Ile Asn Asn Pro Lys Leu Glu Thr Glu Asn Ile Leu Gly 
    290                 295                 300                 


Ile Asp Arg Gly Leu Thr His Ile Leu Ala Tyr Ser Val Phe Glu Pro 
305                 310                 315                 320 


Arg Ser Ser Lys Phe Ile Leu Asn Lys Leu Glu Pro Asn Pro Ile Glu 
                325                 330                 335     


Gly Trp Lys Trp Lys Leu Arg Lys Leu Arg Arg Ser Ile Gln Asn Leu 
            340                 345                 350         


Glu Arg Arg Trp Arg Ala Gln Asp Asn Val Lys Leu Pro Glu Asn Gln 
        355                 360                 365             


Met Lys Lys Asn Leu Arg Ser Ile Glu Asp Lys Val Glu Asn Leu Tyr 
    370                 375                 380                 


His Asn Leu Ser Arg Lys Ile Val Asp Leu Ala Lys Glu Lys Asn Ala 
385                 390                 395                 400 


Cys Ile Val Phe Glu Lys Leu Glu Gly Gln Gly Met Lys Gln His Gly 
                405                 410                 415     


Arg Lys Lys Ser Asp Arg Leu Arg Gly Leu Asn Tyr Lys Leu Ser Leu 
            420                 425                 430         


Phe Asp Tyr Gly Lys Ile Ala Lys Leu Ile Lys Tyr Lys Ala Glu Ile 
        435                 440                 445             


Glu Gly Ile Pro Ile Tyr Arg Ile Asp Ser Ala Tyr Thr Ser Gln Asn 
    450                 455                 460                 


Cys Ala Lys Cys Val Leu Glu Ser Arg Arg Phe Ala Gln Pro Glu Glu 
465                 470                 475                 480 


Ile Ser Cys Leu Asp Asp Phe Lys Glu Gly Asp Asn Leu Asp Lys Arg 
                485                 490                 495     


Ile Leu Glu Gly Thr Gly Leu Val Glu Ala Lys Ile Tyr Lys Lys Leu 
            500                 505                 510         


Leu Lys Glu Lys Lys Glu Asp Phe Glu Ile Glu Glu Asp Ile Ala Met 
        515                 520                 525             


Phe Asp Thr Lys Lys Val Ile Lys Glu Asn Lys Glu Lys Thr Val Ile 
    530                 535                 540                 


Leu Asp Tyr Val Tyr Thr Arg Arg Lys Glu Ile Ile Gly Thr Asn His 
545                 550                 555                 560 


Lys Lys Asn Ile Lys Gly Ile Ala Lys Tyr Thr Gly Asn Thr Lys Ile 
                565                 570                 575     


Gly Tyr Cys Met Lys His Gly Gln Val Asp Ala Asp Leu Asn Ala Ser 
            580                 585                 590         


Arg Thr Ile Ala Leu Cys Lys Asn Phe Asp Ile Asn Asn Pro Glu Ile 
        595                 600                 605             


Trp Lys 
    610 


<210> 36
<211> 632
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Ser Asp Glu Ser Leu Val Ser Ser Glu Asp Lys Leu Ala Ile Lys 
1               5                   10                  15      


Ile Lys Ile Val Pro Asn Ala Glu Gln Ala Lys Met Leu Asp Glu Met 
            20                  25                  30          


Phe Lys Lys Trp Ser Ser Ile Cys Asn Arg Ile Ser Arg Gly Lys Glu 
        35                  40                  45              


Asp Ile Glu Thr Leu Arg Pro Asp Glu Gly Lys Glu Leu Gln Phe Asn 
    50                  55                  60                  


Ser Thr Gln Leu Asn Ser Ala Thr Met Asp Val Ser Asp Leu Lys Lys 
65                  70                  75                  80  


Ala Met Ala Arg Gln Gly Glu Arg Leu Glu Ala Glu Val Ser Lys Leu 
                85                  90                  95      


Arg Gly Arg Tyr Glu Thr Ile Asp Ala Ser Leu Arg Asp Pro Ser Arg 
            100                 105                 110         


Arg His Thr Asn Pro Gln Lys Pro Ser Ser Phe Tyr Pro Ser Asp Trp 
        115                 120                 125             


Asp Ile Ser Gly Arg Leu Thr Pro Arg Phe His Thr Ala Arg His Tyr 
    130                 135                 140                 


Ser Thr Glu Leu Arg Lys Leu Lys Ala Lys Glu Asp Lys Met Leu Lys 
145                 150                 155                 160 


Thr Ile Asn Lys Ile Lys Asn Gly Lys Ile Val Phe Lys Pro Lys Arg 
                165                 170                 175     


Ile Thr Leu Trp Pro Ser Ser Val Asn Met Ala Phe Lys Gly Ser Arg 
            180                 185                 190         


Leu Leu Leu Lys Pro Phe Ala Asn Gly Phe Glu Met Glu Leu Pro Ile 
        195                 200                 205             


Val Ile Ser Pro Gln Lys Thr Ala Asp Gly Lys Ser Gln Lys Ala Ser 
    210                 215                 220                 


Ala Glu Tyr Met Arg Asn Ala Leu Leu Gly Leu Ala Gly Tyr Ser Ile 
225                 230                 235                 240 


Asn Gln Leu Leu Phe Gly Met Asn Arg Ser Gln Lys Met Leu Ala Asn 
                245                 250                 255     


Ala Lys Lys Pro Glu Lys Val Glu Lys Phe Leu Glu Gln Met Lys Asn 
            260                 265                 270         


Lys Asp Ala Asn Phe Asp Lys Lys Ile Lys Ala Leu Glu Gly Lys Trp 
        275                 280                 285             


Leu Leu Asp Arg Lys Leu Lys Glu Ser Glu Lys Ser Ser Ile Ala Val 
    290                 295                 300                 


Val Arg Thr Lys Phe Phe Lys Ser Gly Lys Val Glu Leu Asn Glu Asp 
305                 310                 315                 320 


Tyr Leu Lys Leu Leu Lys His Met Ala Asn Glu Ile Leu Glu Arg Asp 
                325                 330                 335     


Gly Phe Val Asn Leu Asn Lys Tyr Pro Ile Leu Ser Arg Lys Pro Met 
            340                 345                 350         


Lys Arg Tyr Lys Gln Lys Asn Ile Asp Asn Leu Lys Pro Asn Met Trp 
        355                 360                 365             


Lys Tyr Tyr Ile Gln Phe Gly Tyr Glu Pro Ile Phe Glu Arg Lys Ala 
    370                 375                 380                 


Ser Gly Lys Pro Lys Asn Ile Met Gly Ile Asp Arg Gly Leu Thr His 
385                 390                 395                 400 


Leu Leu Ala Val Ala Val Phe Ser Pro Asp Gln Gln Lys Phe Leu Phe 
                405                 410                 415     


Asn His Leu Glu Ser Asn Pro Ile Met His Trp Lys Trp Lys Leu Arg 
            420                 425                 430         


Lys Ile Arg Arg Ser Ile Gln His Met Glu Arg Arg Ile Arg Ala Glu 
        435                 440                 445             


Lys Asn Lys His Ile His Glu Ala Gln Leu Lys Lys Arg Leu Gly Ser 
    450                 455                 460                 


Ile Glu Glu Lys Thr Glu Gln His Tyr His Ile Val Ser Ser Lys Ile 
465                 470                 475                 480 


Ile Asn Trp Ala Ile Glu Tyr Glu Ala Ala Ile Val Leu Glu Ser Leu 
                485                 490                 495     


Ser His Met Lys Gln Arg Gly Gly Lys Lys Ser Val Arg Thr Arg Ala 
            500                 505                 510         


Leu Asn Tyr Ala Leu Ser Leu Phe Asp Tyr Glu Lys Val Ala Arg Leu 
        515                 520                 525             


Ile Thr Tyr Lys Ala Arg Ile Arg Gly Ile Pro Val Tyr Asp Val Leu 
    530                 535                 540                 


Pro Gly Met Thr Ser Lys Thr Cys Ala Thr Cys Leu Leu Asn Gly Ser 
545                 550                 555                 560 


Gln Gly Ala Tyr Val Arg Gly Leu Glu Thr Thr Lys Ala Ala Gly Lys 
                565                 570                 575     


Ala Thr Lys Arg Lys Asn Met Lys Ile Gly Lys Cys Met Val Cys Asn 
            580                 585                 590         


Ser Ser Glu Asn Ser Met Ile Asp Ala Asp Leu Asn Ala Ala Arg Val 
        595                 600                 605             


Ile Ala Ile Cys Lys Tyr Lys Asn Leu Asn Asp Pro Gln Pro Ala Gly 
    610                 615                 620                 


Ser Arg Lys Val Phe Lys Arg Phe 
625                 630         


<210> 37
<211> 625
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Leu Ala Leu Lys Leu Lys Ile Met Pro Thr Glu Lys Gln Ala Glu 
1               5                   10                  15      


Ile Leu Asp Ala Met Phe Trp Lys Trp Ala Ser Ile Cys Ser Arg Ile 
            20                  25                  30          


Ala Lys Met Lys Lys Lys Val Ser Val Lys Glu Asn Lys Lys Glu Leu 
        35                  40                  45              


Ser Lys Lys Ile Pro Ser Asn Ser Asp Ile Trp Phe Ser Lys Thr Gln 
    50                  55                  60                  


Leu Cys Gln Ala Glu Val Asp Val Gly Asp His Lys Lys Ala Leu Lys 
65                  70                  75                  80  


Asn Phe Glu Lys Arg Gln Glu Ser Leu Leu Asp Glu Leu Lys Tyr Lys 
                85                  90                  95      


Val Lys Ala Ile Asn Glu Val Ile Asn Asp Glu Ser Lys Arg Glu Ile 
            100                 105                 110         


Asp Pro Asn Asn Pro Ser Lys Phe Arg Ile Lys Asp Ser Thr Lys Lys 
        115                 120                 125             


Gly Asn Leu Asn Ser Pro Lys Phe Phe Thr Leu Lys Lys Trp Gln Lys 
    130                 135                 140                 


Ile Leu Gln Glu Asn Glu Lys Arg Ile Lys Lys Lys Glu Ser Thr Ile 
145                 150                 155                 160 


Glu Lys Leu Lys Arg Gly Asn Ile Phe Phe Asn Pro Thr Lys Ile Ser 
                165                 170                 175     


Leu His Glu Glu Glu Tyr Ser Ile Asn Phe Gly Ser Ser Lys Leu Leu 
            180                 185                 190         


Leu Asn Cys Phe Tyr Lys Tyr Asn Lys Lys Ser Gly Ile Asn Ser Asp 
        195                 200                 205             


Gln Leu Glu Asn Lys Phe Asn Glu Phe Gln Asn Gly Leu Asn Ile Ile 
    210                 215                 220                 


Cys Ser Pro Leu Gln Pro Ile Arg Gly Ser Ser Lys Arg Ser Phe Glu 
225                 230                 235                 240 


Phe Ile Arg Asn Ser Ile Ile Asn Phe Leu Met Tyr Ser Leu Tyr Ala 
                245                 250                 255     


Lys Leu Phe Gly Ile Pro Arg Ser Val Lys Ala Leu Met Lys Ser Asn 
            260                 265                 270         


Lys Asp Glu Asn Lys Leu Lys Leu Glu Glu Lys Leu Lys Lys Lys Lys 
        275                 280                 285             


Ser Ser Phe Asn Lys Thr Val Lys Glu Phe Glu Lys Met Ile Gly Arg 
    290                 295                 300                 


Lys Leu Ser Asp Asn Glu Ser Lys Ile Leu Asn Asp Glu Ser Lys Lys 
305                 310                 315                 320 


Phe Phe Glu Ile Ile Lys Ser Asn Asn Lys Tyr Ile Pro Ser Glu Glu 
                325                 330                 335     


Tyr Leu Lys Leu Leu Lys Asp Ile Ser Glu Glu Ile Tyr Asn Ser Asn 
            340                 345                 350         


Ile Asp Phe Lys Pro Tyr Lys Tyr Ser Ile Leu Ile Arg Lys Pro Leu 
        355                 360                 365             


Ser Lys Phe Lys Ser Lys Lys Leu Tyr Asn Leu Lys Pro Thr Asp Tyr 
    370                 375                 380                 


Lys Tyr Tyr Leu Gln Leu Ser Tyr Glu Pro Phe Ser Lys Gln Leu Ile 
385                 390                 395                 400 


Ala Thr Lys Thr Ile Leu Gly Ile Asp Arg Gly Leu Lys His Leu Leu 
                405                 410                 415     


Ala Val Ser Val Phe Asp Pro Ser Gln Asn Lys Phe Val Tyr Asn Lys 
            420                 425                 430         


Leu Ile Lys Asn Pro Val Phe Lys Trp Lys Lys Arg Tyr His Asp Leu 
        435                 440                 445             


Lys Arg Ser Ile Arg Asn Arg Glu Arg Arg Ile Arg Ala Leu Thr Gly 
    450                 455                 460                 


Val His Ile His Glu Asn Gln Leu Ile Lys Lys Leu Lys Ser Met Lys 
465                 470                 475                 480 


Asn Lys Ile Asn Val Leu Tyr His Asn Val Ser Lys Asn Ile Val Asp 
                485                 490                 495     


Leu Ala Lys Lys Tyr Glu Ser Thr Ile Val Leu Glu Arg Leu Glu Asn 
            500                 505                 510         


Leu Lys Gln His Gly Arg Ser Lys Gly Lys Arg Tyr Lys Lys Leu Asn 
        515                 520                 525             


Tyr Val Leu Ser Asn Phe Asp Tyr Lys Lys Ile Glu Ser Leu Ile Ser 
    530                 535                 540                 


Tyr Lys Ala Lys Lys Glu Gly Val Pro Val Ser Asn Ile Asn Pro Lys 
545                 550                 555                 560 


Tyr Thr Ser Lys Thr Cys Ala Lys Cys Leu Leu Glu Val Asn Gln Leu 
                565                 570                 575     


Ser Glu Leu Lys Asn Glu Tyr Asn Arg Asp Ser Lys Asn Ser Lys Ile 
            580                 585                 590         


Gly Ile Cys Asn Ile His Gly Gln Ile Asp Ala Asp Leu Asn Ala Ala 
        595                 600                 605             


Arg Val Ile Ala Leu Cys Tyr Ser Lys Asn Leu Asn Glu Pro His Phe 
    610                 615                 620                 


Lys 
625 


<210> 38
<211> 517
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Val Ile Asn Leu Phe Gly Tyr Lys Phe Ala Leu Tyr Pro Asn Lys Thr 
1               5                   10                  15      


Gln Glu Glu Leu Leu Asn Lys His Leu Gly Glu Cys Gly Trp Leu Tyr 
            20                  25                  30          


Asn Lys Ala Ile Glu Gln Asn Glu Tyr Tyr Lys Ala Asp Ser Asn Ile 
        35                  40                  45              


Glu Glu Ala Gln Lys Lys Phe Glu Leu Leu Pro Asp Lys Asn Ser Asp 
    50                  55                  60                  


Glu Ala Lys Val Leu Arg Gly Asn Ile Ser Lys Asp Asn Tyr Val Tyr 
65                  70                  75                  80  


Arg Thr Leu Val Lys Lys Lys Lys Ser Glu Ile Asn Val Gln Ile Arg 
                85                  90                  95      


Lys Ala Val Val Leu Arg Pro Ala Glu Thr Ile Arg Asn Leu Ala Lys 
            100                 105                 110         


Val Lys Lys Lys Gly Leu Ser Val Gly Arg Leu Lys Phe Ile Pro Ile 
        115                 120                 125             


Arg Glu Trp Asp Val Leu Pro Phe Lys Gln Ser Asp Gln Ile Arg Leu 
    130                 135                 140                 


Glu Glu Asn Tyr Leu Ile Leu Glu Pro Tyr Gly Arg Leu Lys Phe Lys 
145                 150                 155                 160 


Met His Arg Pro Leu Leu Gly Lys Pro Lys Thr Phe Cys Ile Lys Arg 
                165                 170                 175     


Thr Ala Thr Asp Arg Trp Thr Ile Ser Phe Ser Thr Glu Tyr Asp Asp 
            180                 185                 190         


Ser Asn Met Arg Lys Asn Asp Gly Gly Gln Val Gly Ile Asp Val Gly 
        195                 200                 205             


Leu Lys Thr His Leu Arg Leu Ser Asn Glu Asn Pro Asp Glu Asp Pro 
    210                 215                 220                 


Arg Tyr Pro Asn Pro Lys Ile Trp Lys Arg Tyr Asp Arg Arg Leu Thr 
225                 230                 235                 240 


Ile Leu Gln Arg Arg Ile Ser Lys Ser Lys Lys Leu Gly Lys Asn Arg 
                245                 250                 255     


Thr Arg Leu Arg Leu Arg Leu Ser Arg Leu Trp Glu Lys Ile Arg Asn 
            260                 265                 270         


Ser Arg Ala Asp Leu Ile Gln Asn Glu Thr Tyr Glu Ile Leu Ser Glu 
        275                 280                 285             


Asn Lys Leu Ile Ala Ile Glu Asp Leu Asn Val Lys Gly Met Gln Glu 
    290                 295                 300                 


Lys Lys Asp Lys Lys Gly Arg Lys Gly Arg Thr Arg Ala Gln Glu Lys 
305                 310                 315                 320 


Gly Leu His Arg Ser Ile Ser Asp Ala Ala Phe Ser Glu Phe Arg Arg 
                325                 330                 335     


Val Leu Glu Tyr Lys Ala Lys Arg Phe Gly Ser Glu Val Lys Pro Val 
            340                 345                 350         


Ser Ala Ile Asp Ser Ser Lys Glu Cys His Asn Cys Gly Asn Lys Lys 
        355                 360                 365             


Gly Met Pro Leu Glu Ser Arg Ile Tyr Glu Cys Pro Lys Cys Gly Leu 
    370                 375                 380                 


Lys Ile Asp Arg Asp Leu Asn Ser Ala Lys Val Ile Leu Ala Arg Ala 
385                 390                 395                 400 


Thr Gly Val Arg Pro Gly Ser Asn Ala Arg Ala Asp Thr Lys Ile Ser 
                405                 410                 415     


Ala Thr Ala Gly Ala Ser Val Gln Thr Glu Gly Thr Val Ser Glu Asp 
            420                 425                 430         


Phe Arg Gln Gln Met Glu Thr Ser Asp Gln Lys Pro Met Gln Gly Glu 
        435                 440                 445             


Gly Ser Lys Glu Pro Pro Met Asn Pro Glu His Lys Ser Ser Gly Arg 
    450                 455                 460                 


Gly Ser Lys His Val Asn Ile Gly Cys Lys Asn Lys Val Gly Leu Tyr 
465                 470                 475                 480 


Asn Glu Asp Glu Asn Ser Arg Ser Thr Glu Lys Gln Ile Met Asp Glu 
                485                 490                 495     


Asn Arg Ser Thr Thr Glu Asp Met Val Glu Ile Gly Ala Leu His Ser 
            500                 505                 510         


Pro Val Leu Thr Thr 
        515         


<210> 39
<211> 410
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Ile Ala Ser Ile Asp Tyr Glu Ala Val Ser Gln Ala Leu Ile Val 
1               5                   10                  15      


Phe Glu Phe Lys Ala Lys Gly Lys Asp Ser Gln Tyr Gln Ala Ile Asp 
            20                  25                  30          


Glu Ala Ile Arg Ser Tyr Arg Phe Ile Arg Asn Ser Cys Leu Arg Tyr 
        35                  40                  45              


Trp Met Asp Asn Lys Lys Val Gly Lys Tyr Asp Leu Asn Lys Tyr Cys 
    50                  55                  60                  


Lys Val Leu Ala Lys Gln Tyr Pro Phe Ala Asn Lys Leu Asn Ser Gln 
65                  70                  75                  80  


Ala Arg Gln Ser Ala Ala Glu Cys Ser Trp Ser Ala Ile Ser Arg Phe 
                85                  90                  95      


Tyr Asp Asn Cys Lys Arg Lys Val Ser Gly Lys Lys Gly Phe Pro Lys 
            100                 105                 110         


Phe Lys Lys His Ala Arg Ser Val Glu Tyr Lys Thr Ser Gly Trp Lys 
        115                 120                 125             


Leu Ser Glu Asn Arg Lys Ala Ile Thr Phe Thr Asp Lys Asn Gly Ile 
    130                 135                 140                 


Gly Lys Leu Lys Leu Lys Gly Thr Tyr Asp Leu His Phe Ser Gln Leu 
145                 150                 155                 160 


Glu Asp Met Lys Arg Val Arg Leu Val Arg Arg Ala Asp Gly Tyr Tyr 
                165                 170                 175     


Val Gln Phe Cys Ile Ser Val Asp Val Lys Val Glu Thr Glu Pro Thr 
            180                 185                 190         


Gly Lys Ala Ile Gly Leu Asp Val Gly Ile Lys Tyr Phe Leu Ala Asp 
        195                 200                 205             


Ser Ser Gly Asn Thr Ile Glu Asn Pro Gln Phe Tyr Arg Lys Ala Glu 
    210                 215                 220                 


Lys Lys Leu Asn Arg Ala Asn Arg Arg Lys Ser Lys Lys Tyr Ile Arg 
225                 230                 235                 240 


Gly Val Lys Pro Gln Ser Lys Asn Tyr His Lys Ala Arg Cys Arg Tyr 
                245                 250                 255     


Ala Arg Lys His Leu Arg Val Ser Arg Gln Arg Lys Glu Tyr Cys Lys 
            260                 265                 270         


Arg Val Ala Tyr Cys Val Ile His Ser Asn Asp Val Val Ala Tyr Glu 
        275                 280                 285             


Asp Leu Asn Val Lys Gly Met Val Lys Asn Arg His Leu Ala Lys Ser 
    290                 295                 300                 


Ile Ser Asp Val Ala Trp Ser Thr Phe Arg His Trp Leu Glu Tyr Phe 
305                 310                 315                 320 


Ala Ile Lys Tyr Gly Lys Leu Thr Ile Pro Val Ala Pro His Asn Thr 
                325                 330                 335     


Ser Gln Asn Cys Ser Asn Cys Asp Lys Lys Val Pro Lys Ser Leu Ser 
            340                 345                 350         


Thr Arg Thr His Ile Cys His His Cys Gly Tyr Ser Glu Asp Arg Asp 
        355                 360                 365             


Val Asn Ala Ala Lys Asn Ile Leu Lys Lys Ala Leu Ser Thr Val Gly 
    370                 375                 380                 


Gln Thr Gly Ser Leu Lys Leu Gly Glu Ile Glu Pro Leu Leu Val Leu 
385                 390                 395                 400 


Glu Gln Ser Cys Thr Arg Lys Phe Asp Leu 
                405                 410 


<210> 40
<211> 486
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Leu Ala Glu Glu Asn Thr Leu His Leu Thr Leu Ala Met Ser Leu Pro 
1               5                   10                  15      


Leu Asn Asp Leu Pro Glu Asn Arg Thr Arg Ser Glu Leu Trp Arg Arg 
            20                  25                  30          


Gln Trp Leu Pro Gln Lys Lys Leu Ser Leu Leu Leu Gly Val Asn Gln 
        35                  40                  45              


Ser Val Arg Lys Ala Ala Ala Asp Cys Leu Arg Trp Phe Glu Pro Tyr 
    50                  55                  60                  


Gln Glu Leu Leu Trp Trp Glu Pro Thr Asp Pro Asp Gly Lys Lys Leu 
65                  70                  75                  80  


Leu Asp Lys Glu Gly Arg Pro Ile Lys Arg Thr Ala Gly His Met Arg 
                85                  90                  95      


Val Leu Arg Lys Leu Glu Glu Ile Ala Pro Phe Arg Gly Tyr Gln Leu 
            100                 105                 110         


Gly Ser Ala Val Lys Asn Gly Leu Arg His Lys Val Ala Asp Leu Leu 
        115                 120                 125             


Leu Ser Tyr Ala Lys Arg Lys Leu Asp Pro Gln Phe Thr Asp Lys Thr 
    130                 135                 140                 


Ser Tyr Pro Ser Ile Gly Asp Gln Phe Pro Ile Val Trp Thr Gly Ala 
145                 150                 155                 160 


Phe Val Cys Tyr Glu Gln Ser Ile Thr Gly Gln Leu Tyr Leu Tyr Leu 
                165                 170                 175     


Pro Leu Phe Pro Arg Gly Ser His Gln Glu Asp Ile Thr Asn Asn Tyr 
            180                 185                 190         


Asp Pro Asp Arg Gly Pro Ala Leu Gln Val Phe Gly Glu Lys Glu Ile 
        195                 200                 205             


Ala Arg Leu Ser Arg Ser Thr Ser Gly Leu Leu Leu Pro Leu Gln Phe 
    210                 215                 220                 


Asp Lys Trp Gly Glu Ala Thr Phe Ile Arg Gly Glu Asn Asn Pro Pro 
225                 230                 235                 240 


Thr Trp Lys Ala Thr His Arg Arg Ser Asp Lys Lys Trp Leu Ser Glu 
                245                 250                 255     


Val Leu Leu Arg Glu Lys Asp Phe Gln Pro Lys Arg Val Glu Leu Leu 
            260                 265                 270         


Val Arg Asn Gly Arg Ile Phe Val Asn Val Ala Cys Glu Ile Pro Thr 
        275                 280                 285             


Lys Pro Leu Leu Glu Val Glu Asn Phe Met Gly Val Ser Phe Gly Leu 
    290                 295                 300                 


Glu His Leu Val Thr Val Val Val Ile Asn Arg Asp Gly Asn Val Val 
305                 310                 315                 320 


His Gln Arg Gln Glu Pro Ala Arg Arg Tyr Glu Lys Thr Tyr Phe Ala 
                325                 330                 335     


Arg Leu Glu Arg Leu Arg Arg Arg Gly Gly Pro Phe Ser Gln Glu Leu 
            340                 345                 350         


Glu Thr Phe His Tyr Arg Gln Val Ala Gln Ile Val Glu Glu Ala Leu 
        355                 360                 365             


Arg Phe Lys Ser Val Pro Ala Val Glu Gln Val Gly Asn Ile Pro Lys 
    370                 375                 380                 


Gly Arg Tyr Asn Pro Arg Leu Asn Leu Arg Leu Ser Tyr Trp Pro Phe 
385                 390                 395                 400 


Gly Lys Leu Ala Asp Leu Thr Ser Tyr Lys Ala Val Lys Glu Gly Leu 
                405                 410                 415     


Pro Lys Pro Tyr Ser Val Tyr Ser Ala Thr Ala Lys Met Leu Cys Ser 
            420                 425                 430         


Thr Cys Gly Ala Ala Asn Lys Glu Gly Asp Gln Pro Ile Ser Leu Lys 
        435                 440                 445             


Gly Pro Thr Val Tyr Cys Gly Asn Cys Gly Thr Arg His Asn Thr Gly 
    450                 455                 460                 


Phe Asn Thr Ala Leu Asn Leu Ala Arg Arg Ala Gln Glu Leu Phe Val 
465                 470                 475                 480 


Lys Gly Val Val Ala Arg 
                485     


<210> 41
<211> 602
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met Ser Gln Ser Leu Leu Lys Trp His Asp Met Ala Gly Arg Asp Lys 
1               5                   10                  15      


Asp Ala Ser Arg Ser Leu Gln Lys Ser Ala Val Glu Gly Val Leu Leu 
            20                  25                  30          


His Leu Thr Ala Ser His Arg Val Ala Leu Glu Met Leu Glu Lys Ser 
        35                  40                  45              


Val Ser Gln Thr Val Ala Val Thr Met Glu Ala Ala Gln Gln Arg Leu 
    50                  55                  60                  


Val Ile Val Leu Glu Asp Asp Pro Thr Lys Ala Thr Ser Arg Lys Arg 
65                  70                  75                  80  


Val Ile Ser Ala Asp Leu Gln Phe Thr Arg Glu Glu Phe Gly Ser Leu 
                85                  90                  95      


Pro Asn Trp Ala Gln Lys Leu Ala Ser Thr Cys Pro Glu Ile Ala Thr 
            100                 105                 110         


Lys Tyr Ala Asp Lys His Ile Asn Ser Ile Arg Ile Ala Trp Gly Val 
        115                 120                 125             


Ala Lys Glu Ser Thr Asn Gly Asp Ala Val Glu Gln Lys Leu Gln Trp 
    130                 135                 140                 


Gln Ile Arg Leu Leu Asp Val Thr Met Phe Leu Gln Gln Leu Val Leu 
145                 150                 155                 160 


Gln Leu Ala Asp Lys Ala Leu Leu Glu Gln Ile Pro Ser Ser Ile Arg 
                165                 170                 175     


Gly Gly Ile Gly Gln Glu Val Ala Gln Gln Val Thr Ser His Ile Gln 
            180                 185                 190         


Leu Leu Asp Ser Gly Thr Val Leu Lys Ala Glu Leu Pro Thr Ile Ser 
        195                 200                 205             


Asp Arg Asn Ser Glu Leu Ala Arg Lys Gln Trp Glu Asp Ala Ile Gln 
    210                 215                 220                 


Thr Val Cys Thr Tyr Ala Leu Pro Phe Ser Arg Glu Arg Ala Arg Ile 
225                 230                 235                 240 


Leu Asp Pro Gly Lys Tyr Ala Ala Glu Asp Pro Arg Gly Asp Arg Leu 
                245                 250                 255     


Ile Asn Ile Asp Pro Met Trp Ala Arg Val Leu Lys Gly Pro Thr Val 
            260                 265                 270         


Lys Ser Leu Pro Leu Leu Phe Val Ser Gly Ser Ser Ile Arg Ile Val 
        275                 280                 285             


Lys Leu Thr Leu Pro Arg Lys His Ala Ala Gly His Lys His Thr Phe 
    290                 295                 300                 


Thr Ala Thr Tyr Leu Val Leu Pro Val Ser Arg Glu Trp Ile Asn Ser 
305                 310                 315                 320 


Leu Pro Gly Thr Val Gln Glu Lys Val Gln Trp Trp Lys Lys Pro Asp 
                325                 330                 335     


Val Leu Ala Thr Gln Glu Leu Leu Val Gly Lys Gly Ala Leu Lys Lys 
            340                 345                 350         


Ser Ala Asn Thr Leu Val Ile Pro Ile Ser Ala Gly Lys Lys Arg Phe 
        355                 360                 365             


Phe Asn His Ile Leu Pro Ala Leu Gln Arg Gly Phe Pro Leu Gln Trp 
    370                 375                 380                 


Gln Arg Ile Val Gly Arg Ser Tyr Arg Arg Pro Ala Thr His Arg Lys 
385                 390                 395                 400 


Trp Phe Ala Gln Leu Thr Ile Gly Tyr Thr Asn Pro Ser Ser Leu Pro 
                405                 410                 415     


Glu Met Ala Leu Gly Ile His Phe Gly Met Lys Asp Ile Leu Trp Trp 
            420                 425                 430         


Ala Leu Ala Asp Lys Gln Gly Asn Ile Leu Lys Asp Gly Ser Ile Pro 
        435                 440                 445             


Gly Asn Ser Ile Leu Asp Phe Ser Leu Gln Glu Lys Gly Lys Ile Glu 
    450                 455                 460                 


Arg Gln Gln Lys Ala Gly Lys Asn Val Ala Gly Lys Lys Tyr Gly Lys 
465                 470                 475                 480 


Ser Leu Leu Asn Ala Thr Tyr Arg Val Val Asn Gly Val Leu Glu Phe 
                485                 490                 495     


Ser Lys Gly Ile Ser Ala Glu His Ala Ser Gln Pro Ile Gly Leu Gly 
            500                 505                 510         


Leu Glu Thr Ile Arg Phe Val Asp Lys Ala Ser Gly Ser Ser Pro Val 
        515                 520                 525             


Asn Ala Arg His Ser Asn Trp Asn Tyr Gly Gln Leu Ser Gly Ile Phe 
    530                 535                 540                 


Ala Asn Lys Ala Gly Pro Ala Gly Phe Ser Val Thr Glu Ile Thr Leu 
545                 550                 555                 560 


Lys Lys Ala Gln Arg Asp Leu Ser Asp Ala Glu Gln Ala Arg Val Leu 
                565                 570                 575     


Ala Ile Glu Ala Thr Lys Arg Phe Ala Ser Arg Ile Lys Arg Leu Ala 
            580                 585                 590         


Thr Lys Arg Lys Asp Asp Thr Leu Phe Val 
        595                 600         


<210> 42
<211> 494
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Val Glu Pro Val Glu Lys Glu Arg Phe Tyr Tyr Arg Thr Tyr Thr Phe 
1               5                   10                  15      


Arg Leu Asp Gly Gln Pro Arg Thr Gln Asn Leu Thr Thr Gln Ser Gly 
            20                  25                  30          


Trp Gly Leu Leu Thr Lys Ala Val Leu Asp Asn Thr Lys His Tyr Trp 
        35                  40                  45              


Glu Ile Val His His Ala Arg Ile Ala Asn Gln Pro Ile Val Phe Glu 
    50                  55                  60                  


Asn Pro Val Ile Asp Glu Gln Gly Asn Pro Lys Leu Asn Lys Leu Gly 
65                  70                  75                  80  


Gln Pro Arg Phe Trp Lys Arg Pro Ile Ser Asp Ile Val Asn Gln Leu 
                85                  90                  95      


Arg Ala Leu Phe Glu Asn Gln Asn Pro Tyr Gln Leu Gly Ser Ser Leu 
            100                 105                 110         


Ile Gln Gly Thr Tyr Trp Asp Val Ala Glu Asn Leu Ala Ser Trp Tyr 
        115                 120                 125             


Ala Leu Asn Lys Glu Tyr Leu Ala Gly Thr Ala Thr Trp Gly Glu Pro 
    130                 135                 140                 


Ser Phe Pro Glu Pro His Pro Leu Thr Glu Ile Asn Gln Trp Met Pro 
145                 150                 155                 160 


Leu Thr Phe Ser Ser Gly Lys Val Val Arg Leu Leu Lys Asn Ala Ser 
                165                 170                 175     


Gly Arg Tyr Phe Ile Gly Leu Pro Ile Leu Gly Glu Asn Asn Pro Cys 
            180                 185                 190         


Tyr Arg Met Arg Thr Ile Glu Lys Leu Ile Pro Cys Asp Gly Lys Gly 
        195                 200                 205             


Arg Val Thr Ser Gly Ser Leu Ile Leu Phe Pro Leu Val Gly Ile Tyr 
    210                 215                 220                 


Ala Gln Gln His Arg Arg Met Thr Asp Ile Cys Glu Ser Ile Arg Thr 
225                 230                 235                 240 


Glu Lys Gly Lys Leu Ala Trp Ala Gln Val Ser Ile Asp Tyr Val Arg 
                245                 250                 255     


Glu Val Asp Lys Arg Arg Arg Met Arg Arg Thr Arg Lys Ser Gln Gly 
            260                 265                 270         


Trp Ile Gln Gly Pro Trp Gln Glu Val Phe Ile Leu Arg Leu Val Leu 
        275                 280                 285             


Ala His Lys Ala Pro Lys Leu Tyr Lys Pro Arg Cys Phe Ala Gly Ile 
    290                 295                 300                 


Ser Leu Gly Pro Lys Thr Leu Ala Ser Cys Val Ile Leu Asp Gln Asp 
305                 310                 315                 320 


Glu Arg Val Val Glu Lys Gln Gln Trp Ser Gly Ser Glu Leu Leu Ser 
                325                 330                 335     


Leu Ile His Gln Gly Glu Glu Arg Leu Arg Ser Leu Arg Glu Gln Ser 
            340                 345                 350         


Lys Pro Thr Trp Asn Ala Ala Tyr Arg Lys Gln Leu Lys Ser Leu Ile 
        355                 360                 365             


Asn Thr Gln Val Phe Thr Ile Val Thr Phe Leu Arg Glu Arg Gly Ala 
    370                 375                 380                 


Ala Val Arg Leu Glu Ser Ile Ala Arg Val Arg Lys Ser Thr Pro Ala 
385                 390                 395                 400 


Pro Pro Val Asn Phe Leu Leu Ser His Trp Ala Tyr Arg Gln Ile Thr 
                405                 410                 415     


Glu Arg Leu Lys Asp Leu Ala Ile Arg Asn Gly Met Pro Leu Thr His 
            420                 425                 430         


Ser Asn Gly Ser Tyr Gly Val Arg Phe Thr Cys Ser Gln Cys Gly Ala 
        435                 440                 445             


Thr Asn Gln Gly Ile Lys Asp Pro Thr Lys Tyr Lys Val Asp Ile Glu 
    450                 455                 460                 


Ser Glu Thr Phe Leu Cys Ser Ile Cys Ser His Arg Glu Ile Ala Ala 
465                 470                 475                 480 


Val Asn Thr Ala Thr Asn Leu Ala Lys Gln Leu Leu Asp Glu 
                485                 490                 


<210> 43
<211> 526
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met Asn Asp Thr Glu Thr Ser Glu Thr Leu Thr Ser His Arg Thr Val 
1               5                   10                  15      


Cys Ala His Leu His Val Val Gly Glu Thr Gly Ser Leu Pro Arg Leu 
            20                  25                  30          


Val Glu Ala Ala Leu Ala Glu Leu Ile Thr Leu Asn Gly Arg Ala Thr 
        35                  40                  45              


Gln Ala Leu Leu Ser Leu Ala Lys Asn Gly Leu Val Leu Arg Arg Asp 
    50                  55                  60                  


Lys Glu Glu Asn Leu Ile Ala Ala Glu Leu Thr Leu Pro Cys Arg Lys 
65                  70                  75                  80  


Asn Lys Tyr Ala Asp Val Ala Ala Lys Ala Gly Glu Pro Ile Leu Ala 
                85                  90                  95      


Thr Arg Ile Asn Asn Lys Gly Lys Leu Val Thr Lys Lys Trp Tyr Gly 
            100                 105                 110         


Glu Gly Asn Ser Tyr His Ile Val Arg Phe Thr Pro Glu Thr Gly Met 
        115                 120                 125             


Phe Thr Val Arg Val Phe Asp Arg Tyr Ala Phe Asp Glu Glu Leu Leu 
    130                 135                 140                 


His Leu His Ser Glu Val Val Phe Gly Ser Asp Leu Pro Lys Gly Ile 
145                 150                 155                 160 


Lys Ala Lys Thr Asp Ser Leu Pro Ala Asn Phe Leu Gln Ala Val Phe 
                165                 170                 175     


Thr Ser Phe Leu Glu Leu Pro Phe Gln Gly Phe Pro Asp Ile Val Val 
            180                 185                 190         


Lys Pro Ala Met Lys Gln Ala Ala Glu Gln Leu Leu Ser Tyr Val Gln 
        195                 200                 205             


Leu Glu Ala Gly Glu Asn Gln Gln Ala Glu Tyr Pro Asp Thr Asn Glu 
    210                 215                 220                 


Arg Asp Pro Glu Leu Arg Leu Val Glu Trp Gln Lys Ser Leu His Glu 
225                 230                 235                 240 


Leu Ser Val Arg Thr Glu Pro Phe Glu Phe Val Arg Ala Arg Asp Ile 
                245                 250                 255     


Asp Tyr Tyr Ala Glu Thr Asp Arg Arg Gly Asn Arg Phe Val Asn Ile 
            260                 265                 270         


Thr Pro Glu Trp Thr Lys Phe Ala Glu Ser Pro Phe Ala Arg Arg Leu 
        275                 280                 285             


Pro Leu Lys Ile Pro Pro Glu Phe Cys Ile Leu Leu Arg Arg Lys Thr 
    290                 295                 300                 


Glu Gly His Ala Lys Ile Pro Asn Arg Ile Tyr Leu Gly Leu Gln Ile 
305                 310                 315                 320 


Phe Asp Gly Val Thr Pro Asp Ser Thr Leu Gly Val Leu Ala Thr Ala 
                325                 330                 335     


Glu Asp Gly Lys Leu Phe Trp Trp His Asp His Leu Asp Glu Phe Ser 
            340                 345                 350         


Asn Leu Glu Gly Lys Pro Glu Pro Lys Leu Lys Asn Lys Pro Gln Leu 
        355                 360                 365             


Leu Met Val Ser Leu Glu Tyr Asp Arg Glu Gln Arg Phe Glu Glu Ser 
    370                 375                 380                 


Val Gly Gly Asp Arg Lys Ile Cys Leu Val Thr Leu Lys Glu Thr Arg 
385                 390                 395                 400 


Asn Phe Arg Arg Gly Trp Asn Gly Arg Ile Leu Gly Ile His Phe Gln 
                405                 410                 415     


His Asn Pro Val Ile Thr Trp Ala Leu Met Asp His Asp Ala Glu Val 
            420                 425                 430         


Leu Glu Lys Gly Phe Ile Glu Gly Asn Ala Phe Leu Gly Lys Ala Leu 
        435                 440                 445             


Asp Lys Gln Ala Leu Asn Glu Tyr Leu Gln Lys Gly Gly Lys Trp Val 
    450                 455                 460                 


Gly Asp Arg Ser Phe Gly Asn Lys Leu Lys Gly Ile Thr His Thr Leu 
465                 470                 475                 480 


Ala Ser Leu Ile Val Arg Leu Ala Arg Glu Lys Asp Ala Trp Ile Ala 
                485                 490                 495     


Leu Glu Glu Ile Ser Trp Val Gln Lys Gln Ser Ala Asp Ser Val Ala 
            500                 505                 510         


Asn His Glu Ile Val Glu Gln Pro His His Ser Leu Thr Arg 
        515                 520                 525     


<210> 44
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Asn Asp Thr Glu Thr Ser Glu Thr Leu Thr Ser His Arg Thr Val 
1               5                   10                  15      


Cys Ala His Leu His Val Val Gly Glu Thr Gly Ser Leu Pro Arg Leu 
            20                  25                  30          


Val Glu Ala Ala Leu Ala Glu Leu Ile Thr Leu Asn Gly Arg Ala Thr 
        35                  40                  45              


Gln Ala Leu Leu Ser Leu Ala Lys Asn Gly Leu Val Leu Arg Arg Asp 
    50                  55                  60                  


Lys Glu Glu Asn Leu Ile Ala Ala Glu Leu Thr Leu Pro Cys Arg Lys 
65                  70                  75                  80  


Asn Lys Tyr Ala Asp Val Ala Ala Lys Ala Gly Glu Pro Ile Leu Ala 
                85                  90                  95      


Thr Arg Ile Asn Asn Lys Gly Lys Leu Val Thr Lys Lys Trp Tyr Gly 
            100                 105                 110         


Glu Gly Asn Ser Tyr His Ile Val Arg Phe Thr Pro Glu Thr Gly Met 
        115                 120                 125             


Phe Thr Val Arg Val Phe Asp Arg Tyr Ala Phe Asp Glu Glu Leu Leu 
    130                 135                 140                 


His Leu His Ser Glu Val Val Phe Gly Ser Asp Leu Pro Lys Gly Ile 
145                 150                 155                 160 


Lys Ala Lys Thr Asp Ser Leu Pro Ala Asn Phe Leu Gln Ala Val Phe 
                165                 170                 175     


Thr Ser Phe Leu Glu Leu Pro Phe Gln Gly Phe Pro Asp Ile Val Val 
            180                 185                 190         


Lys Pro Ala Met Lys Gln Ala Ala Glu Gln Leu Leu Ser Tyr Val Gln 
        195                 200                 205             


Leu Glu Ala Gly Glu Asn Gln Gln Ala Glu Tyr Pro Asp Thr Asn Glu 
    210                 215                 220                 


Arg Asp Pro Glu Leu Arg Leu Val Glu Trp Gln Lys Ser Leu His Glu 
225                 230                 235                 240 


Leu Ser Val Arg Thr Glu Pro Phe Glu Phe Val Arg Ala Arg Asp Ile 
                245                 250                 255     


Asp Tyr Tyr Ala Glu Thr Asp Arg Arg Gly Asn Arg Phe Val Asn Ile 
            260                 265                 270         


Thr Pro Glu Trp Thr Lys Phe Ala Glu Ser Pro Phe Ala Arg Arg Leu 
        275                 280                 285             


Pro Leu Lys Ile Pro Pro Glu Phe Cys Ile Leu Leu Arg Arg Lys Thr 
    290                 295                 300                 


Glu Gly His Ala Lys Ile Pro Asn Arg Ile Tyr Leu Gly Leu Gln Ile 
305                 310                 315                 320 


Phe Asp Gly Val Thr Pro Asp Ser Thr Leu Gly Val Leu Ala Thr Ala 
                325                 330                 335     


Glu Asp Gly Lys Leu Phe Trp Trp His Asp His Leu Asp Glu Phe Ser 
            340                 345                 350         


Asn Leu Glu Gly Lys Pro Glu Pro Lys Leu Lys Asn Lys Pro Gln Leu 
        355                 360                 365             


Leu Met Val Ser Leu Glu Tyr Asp Arg Glu Gln Arg Phe Glu Glu Ser 
    370                 375                 380                 


Val Gly Gly Asp Arg Lys Ile Cys Leu Val Thr Leu Lys Glu Thr Arg 
385                 390                 395                 400 


Asn Phe Arg Arg Gly Arg His Gly His Thr Arg Thr Asp Arg Leu Pro 
                405                 410                 415     


Ala Gly Asn Thr Leu Trp Arg Ala Asp Phe Ala Thr Ser Ala Glu Val 
            420                 425                 430         


Ala Ala Pro Lys Trp Asn Gly Arg Ile Leu Gly Ile His Phe Gln His 
        435                 440                 445             


Asn Pro Val Ile Thr Trp Ala Leu Met Asp His Asp Ala Glu Val Leu 
    450                 455                 460                 


Glu Lys Gly Phe Ile Glu Gly Asn Ala Phe Leu Gly Lys Ala Leu Asp 
465                 470                 475                 480 


Lys Gln Ala Leu Asn Glu Tyr Leu Gln Lys Gly Gly Lys Trp Val Gly 
                485                 490                 495     


Asp Arg Ser Phe Gly Asn Lys Leu Lys Gly Ile Thr His Thr Leu Ala 
            500                 505                 510         


Ser Leu Ile Val Arg Leu Ala Arg Glu Lys Asp Ala Trp Ile Ala Leu 
        515                 520                 525             


Glu Glu Ile Ser Trp Val Gln Lys Gln Ser Ala Asp Ser Val Ala Asn 
    530                 535                 540                 


Arg Arg Phe Ser Met Trp Asn Tyr Ser Arg Leu Ala Thr Leu Ile Glu 
545                 550                 555                 560 


Trp Leu Gly Thr Asp Ile Ala Thr Arg Asp Cys Gly Thr Ala Ala Pro 
                565                 570                 575     


Leu Ala His Lys Val Ser Asp Tyr Leu Thr His Phe Thr Cys Pro Glu 
            580                 585                 590         


Cys Gly Ala Cys Arg Lys Ala Gly Gln Lys Lys Glu Ile Ala Asp Thr 
        595                 600                 605             


Val Arg Ala Gly Asp Ile Leu Thr Cys Arg Lys Cys Gly Phe Ser Gly 
    610                 615                 620                 


Pro Ile Pro Asp Asn Phe Ile Ala Glu Phe Val Ala Lys Lys Ala Leu 
625                 630                 635                 640 


Glu Arg Met Leu Lys Lys Lys Pro Val 
                645                 


<210> 45
<211> 414
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Ala Lys Arg Asn Phe Gly Glu Lys Ser Glu Ala Leu Tyr Arg Ala 
1               5                   10                  15      


Val Arg Phe Glu Val Arg Pro Ser Lys Glu Glu Leu Ser Ile Leu Leu 
            20                  25                  30          


Ala Val Ser Glu Val Leu Arg Met Leu Phe Asn Ser Ala Leu Ala Glu 
        35                  40                  45              


Arg Gln Gln Val Phe Thr Glu Phe Ile Ala Ser Leu Tyr Ala Glu Leu 
    50                  55                  60                  


Lys Ser Ala Ser Val Pro Glu Glu Ile Ser Glu Ile Arg Lys Lys Leu 
65                  70                  75                  80  


Arg Glu Ala Tyr Lys Glu His Ser Ile Ser Leu Phe Asp Gln Ile Asn 
                85                  90                  95      


Ala Leu Thr Ala Arg Arg Val Glu Asp Glu Ala Phe Ala Ser Val Thr 
            100                 105                 110         


Arg Asn Trp Gln Glu Glu Thr Leu Asp Ala Leu Asp Gly Ala Tyr Lys 
        115                 120                 125             


Ser Phe Leu Ser Leu Arg Arg Lys Gly Asp Tyr Asp Ala His Ser Pro 
    130                 135                 140                 


Arg Ser Arg Asp Ser Gly Phe Phe Gln Lys Ile Pro Gly Arg Ser Gly 
145                 150                 155                 160 


Phe Lys Ile Gly Glu Gly Arg Ile Ala Leu Ser Cys Gly Ala Gly Arg 
                165                 170                 175     


Lys Leu Ser Phe Pro Ile Pro Asp Tyr Gln Gln Gly Arg Leu Ala Glu 
            180                 185                 190         


Thr Thr Lys Leu Lys Lys Phe Glu Leu Tyr Arg Asp Gln Pro Asn Leu 
        195                 200                 205             


Ala Lys Ser Gly Arg Phe Trp Ile Ser Val Val Tyr Glu Leu Pro Lys 
    210                 215                 220                 


Pro Glu Ala Thr Thr Cys Gln Ser Glu Gln Val Ala Phe Val Ala Leu 
225                 230                 235                 240 


Gly Ala Ser Ser Ile Gly Val Val Ser Gln Arg Gly Glu Glu Val Ile 
                245                 250                 255     


Ala Leu Trp Arg Ser Asp Lys His Trp Val Pro Lys Ile Glu Ala Val 
            260                 265                 270         


Glu Glu Arg Met Lys Arg Arg Val Lys Gly Ser Arg Gly Trp Leu Arg 
        275                 280                 285             


Leu Leu Asn Ser Gly Lys Arg Arg Met His Met Ile Ser Ser Arg Gln 
    290                 295                 300                 


His Val Gln Asp Glu Arg Glu Ile Val Asp Tyr Leu Val Arg Asn His 
305                 310                 315                 320 


Gly Ser His Phe Val Val Thr Glu Leu Val Val Arg Ser Lys Glu Gly 
                325                 330                 335     


Lys Leu Ala Asp Ser Ser Lys Pro Glu Arg Gly Gly Ser Leu Gly Leu 
            340                 345                 350         


Asn Trp Ala Ala Gln Asn Thr Gly Ser Leu Ser Arg Leu Val Arg Gln 
        355                 360                 365             


Leu Glu Glu Lys Val Lys Glu His Gly Gly Ser Val Arg Lys His Lys 
    370                 375                 380                 


Leu Thr Leu Thr Glu Ala Pro Pro Ala Arg Gly Ala Glu Asn Lys Leu 
385                 390                 395                 400 


Trp Met Ala Arg Lys Leu Arg Glu Ser Phe Leu Lys Glu Val 
                405                 410                 


<210> 46
<211> 413
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Leu Ala Lys Asn Asp Glu Lys Glu Leu Leu Tyr Gln Ser Val Lys Phe 
1               5                   10                  15      


Glu Ile Tyr Pro Asp Glu Ser Lys Ile Arg Val Leu Thr Arg Val Ser 
            20                  25                  30          


Asn Ile Leu Val Leu Val Trp Asn Ser Ala Leu Gly Glu Arg Arg Ala 
        35                  40                  45              


Arg Phe Glu Leu Tyr Ile Ala Pro Leu Tyr Glu Glu Leu Lys Lys Phe 
    50                  55                  60                  


Pro Arg Lys Ser Ala Glu Ser Asn Ala Leu Arg Gln Lys Ile Arg Glu 
65                  70                  75                  80  


Gly Tyr Lys Glu His Ile Pro Thr Phe Phe Asp Gln Leu Lys Lys Leu 
                85                  90                  95      


Leu Thr Pro Met Arg Lys Glu Asp Pro Ala Leu Leu Gly Ser Val Pro 
            100                 105                 110         


Arg Ala Tyr Gln Glu Glu Thr Leu Asn Thr Leu Asn Gly Ser Phe Val 
        115                 120                 125             


Ser Phe Met Thr Leu Arg Arg Asn Asn Asp Met Asp Ala Lys Pro Pro 
    130                 135                 140                 


Lys Gly Arg Ala Glu Asp Arg Phe His Glu Ile Ser Gly Arg Ser Gly 
145                 150                 155                 160 


Phe Lys Ile Asp Gly Ser Glu Phe Val Leu Ser Thr Lys Glu Gln Lys 
                165                 170                 175     


Leu Arg Phe Pro Ile Pro Asn Tyr Gln Leu Glu Lys Leu Lys Glu Ala 
            180                 185                 190         


Lys Gln Ile Lys Lys Phe Thr Leu Tyr Gln Ser Arg Asp Arg Arg Phe 
        195                 200                 205             


Trp Ile Ser Ile Ala Tyr Glu Ile Glu Leu Pro Asp Gln Arg Pro Phe 
    210                 215                 220                 


Asn Pro Glu Glu Val Ile Tyr Ile Ala Phe Gly Ala Ser Ser Ile Gly 
225                 230                 235                 240 


Val Ile Ser Pro Glu Gly Glu Lys Val Ile Asp Phe Trp Arg Pro Asp 
                245                 250                 255     


Lys His Trp Lys Pro Lys Ile Lys Glu Val Glu Asn Arg Met Arg Ser 
            260                 265                 270         


Cys Lys Lys Gly Ser Arg Ala Trp Lys Lys Arg Ala Ala Ala Arg Arg 
        275                 280                 285             


Lys Met Tyr Ala Met Thr Gln Arg Gln Gln Lys Leu Asn His Arg Glu 
    290                 295                 300                 


Ile Val Ala Ser Leu Leu Arg Leu Gly Phe His Phe Val Val Thr Glu 
305                 310                 315                 320 


Tyr Thr Val Arg Ser Lys Pro Gly Lys Leu Ala Asp Gly Ser Asn Pro 
                325                 330                 335     


Lys Arg Gly Gly Ala Pro Gln Gly Phe Asn Trp Ser Ala Gln Asn Thr 
            340                 345                 350         


Gly Ser Phe Gly Glu Phe Ile Leu Trp Leu Lys Gln Lys Val Lys Glu 
        355                 360                 365             


Gln Gly Gly Thr Val Gln Thr Phe Arg Leu Val Leu Gly Gln Ser Glu 
    370                 375                 380                 


Arg Pro Glu Lys Arg Gly Arg Asp Asn Lys Ile Glu Met Val Arg Leu 
385                 390                 395                 400 


Leu Arg Glu Lys Tyr Leu Glu Ser Gln Thr Ile Val Val 
                405                 410             


<210> 47
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Ala Lys Gly Lys Lys Lys Glu Gly Lys Pro Leu Tyr Arg Ala Val 
1               5                   10                  15      


Arg Phe Glu Ile Phe Pro Thr Ser Asp Gln Ile Thr Leu Phe Leu Arg 
            20                  25                  30          


Val Ser Lys Asn Leu Gln Gln Val Trp Asn Glu Ala Trp Gln Glu Arg 
        35                  40                  45              


Gln Ser Cys Tyr Glu Gln Phe Phe Gly Ser Ile Tyr Glu Arg Ile Gly 
    50                  55                  60                  


Gln Ala Lys Lys Arg Ala Gln Glu Ala Gly Phe Ser Glu Val Trp Glu 
65                  70                  75                  80  


Asn Glu Ala Lys Lys Gly Leu Asn Lys Lys Leu Arg Gln Gln Glu Ile 
                85                  90                  95      


Ser Met Gln Leu Val Ser Glu Lys Glu Ser Leu Leu Gln Glu Leu Ser 
            100                 105                 110         


Ile Ala Phe Gln Glu His Gly Val Thr Leu Tyr Asp Gln Ile Asn Gly 
        115                 120                 125             


Leu Thr Ala Arg Arg Ile Ile Gly Glu Phe Ala Leu Ile Pro Arg Asn 
    130                 135                 140                 


Trp Gln Glu Glu Thr Leu Asp Ser Leu Asp Gly Ser Phe Lys Ser Phe 
145                 150                 155                 160 


Leu Ala Leu Arg Lys Asn Gly Asp Pro Asp Ala Lys Pro Pro Arg Gln 
                165                 170                 175     


Arg Val Ser Glu Asn Ser Phe Tyr Lys Ile Pro Gly Arg Ser Gly Phe 
            180                 185                 190         


Lys Val Ser Asn Gly Gln Ile Tyr Leu Ser Phe Gly Lys Ile Gly Gln 
        195                 200                 205             


Thr Leu Thr Ser Val Ile Pro Glu Phe Gln Leu Lys Arg Leu Glu Thr 
    210                 215                 220                 


Ala Ile Lys Leu Lys Lys Phe Glu Leu Cys Arg Asp Glu Arg Asp Met 
225                 230                 235                 240 


Ala Lys Pro Gly Arg Phe Trp Ile Ser Val Ala Tyr Glu Ile Pro Lys 
                245                 250                 255     


Pro Glu Lys Val Pro Val Val Ser Lys Gln Ile Thr Tyr Leu Ala Ile 
            260                 265                 270         


Gly Ala Ser Arg Leu Gly Val Val Ser Pro Lys Gly Glu Phe Cys Leu 
        275                 280                 285             


Asn Leu Pro Arg Ser Asp Tyr His Trp Lys Pro Gln Ile Asn Ala Leu 
    290                 295                 300                 


Gln Glu Arg Leu Glu Gly Val Val Lys Gly Ser Arg Lys Trp Lys Lys 
305                 310                 315                 320 


Arg Met Ala Ala Cys Thr Arg Met Phe Ala Lys Leu Gly His Gln Gln 
                325                 330                 335     


Lys Gln His Gly Gln Tyr Glu Val Val Lys Lys Leu Leu Arg His Gly 
            340                 345                 350         


Val His Phe Val Val Thr Glu Leu Lys Val Arg Ser Lys Pro Gly Ala 
        355                 360                 365             


Leu Ala Asp Ala Ser Lys Ser Asp Arg Lys Gly Ser Pro Thr Gly Pro 
    370                 375                 380                 


Asn Trp Ser Ala Gln Asn Thr Gly Asn Ile Ala Arg Leu Ile Gln Lys 
385                 390                 395                 400 


Leu Thr Asp Lys Ala Ser Glu His Gly Gly Thr Val Ile Lys Arg Asn 
                405                 410                 415     


Pro Pro Leu Leu Ser Leu Glu Glu Arg Gln Leu Pro Asp Ala Gln Arg 
            420                 425                 430         


Lys Ile Phe Ile Ala Lys Lys Leu Arg Glu Glu Phe Leu Ala Asp Gln 
        435                 440                 445             


Lys 
    


<210> 48
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Ala Lys Arg Glu Lys Lys Asp Asp Val Val Leu Arg Gly Thr Lys 
1               5                   10                  15      


Met Arg Ile Tyr Pro Thr Asp Arg Gln Val Thr Leu Met Asp Met Trp 
            20                  25                  30          


Arg Arg Arg Cys Ile Ser Leu Trp Asn Leu Leu Leu Asn Leu Glu Thr 
        35                  40                  45              


Ala Ala Tyr Gly Ala Lys Asn Thr Arg Ser Lys Leu Gly Trp Arg Ser 
    50                  55                  60                  


Ile Trp Ala Arg Val Val Glu Glu Asn His Ala Lys Ala Leu Ile Val 
65                  70                  75                  80  


Tyr Gln His Gly Lys Cys Lys Lys Asp Gly Ser Phe Val Leu Lys Arg 
                85                  90                  95      


Asp Gly Thr Val Lys His Pro Pro Arg Glu Arg Phe Pro Gly Asp Arg 
            100                 105                 110         


Lys Ile Leu Leu Gly Leu Phe Asp Ala Leu Arg His Thr Leu Asp Lys 
        115                 120                 125             


Gly Ala Lys Cys Lys Cys Asn Val Asn Gln Pro Tyr Ala Leu Thr Arg 
    130                 135                 140                 


Ala Trp Leu Asp Glu Thr Gly His Gly Ala Arg Thr Ala Asp Ile Ile 
145                 150                 155                 160 


Ala Trp Leu Lys Asp Phe Lys Gly Glu Cys Asp Cys Thr Ala Ile Ser 
                165                 170                 175     


Thr Ala Ala Lys Tyr Cys Pro Ala Pro Pro Thr Ala Glu Leu Leu Thr 
            180                 185                 190         


Lys Ile Lys Arg Ala Ala Pro Ala Asp Asp Leu Pro Val Asp Gln Ala 
        195                 200                 205             


Ile Leu Leu Asp Leu Phe Gly Ala Leu Arg Gly Gly Leu Lys Gln Lys 
    210                 215                 220                 


Glu Cys Asp His Thr His Ala Arg Thr Val Ala Tyr Phe Glu Lys His 
225                 230                 235                 240 


Glu Leu Ala Gly Arg Ala Glu Asp Ile Leu Ala Trp Leu Ile Ala His 
                245                 250                 255     


Gly Gly Thr Cys Asp Cys Lys Ile Val Glu Glu Ala Ala Asn His Cys 
            260                 265                 270         


Pro Gly Pro Arg Leu Phe Ile Trp Glu His Glu Leu Ala Met Ile Met 
        275                 280                 285             


Ala Arg Leu Lys Ala Glu Pro Arg Thr Glu Trp Ile Gly Asp Leu Pro 
    290                 295                 300                 


Ser His Ala Ala Gln Thr Val Val Lys Asp Leu Val Lys Ala Leu Gln 
305                 310                 315                 320 


Thr Met Leu Lys Glu Arg Ala Lys Ala Ala Ala Gly Asp Glu Ser Ala 
                325                 330                 335     


Arg Lys Thr Gly Phe Pro Lys Phe Lys Lys Gln Ala Tyr Ala Ala Gly 
            340                 345                 350         


Ser Val Tyr Phe Pro Asn Thr Thr Met Phe Phe Asp Val Ala Ala Gly 
        355                 360                 365             


Arg Val Gln Leu Pro Asn Gly Cys Gly Ser Met Arg Cys Glu Ile Pro 
    370                 375                 380                 


Arg Gln Leu Val Ala Glu Leu Leu Glu Arg Asn Leu Lys Pro Gly Leu 
385                 390                 395                 400 


Val Ile Gly Ala Gln Leu Gly Leu Leu Gly Gly Arg Ile Trp Arg Gln 
                405                 410                 415     


Gly Asp Arg Trp Tyr Leu Ser Cys Gln Trp Glu Arg Pro Gln Pro Thr 
            420                 425                 430         


Leu Leu Pro Lys Thr Gly Arg Thr Ala Gly Val Lys Ile Ala Ala Ser 
        435                 440                 445             


Ile Val Phe Thr Thr Tyr Asp Asn Arg Gly Gln Thr Lys Glu Tyr Pro 
    450                 455                 460                 


Met Pro Pro Ala Asp Lys Lys Leu Thr Ala Val His Leu Val Ala Gly 
465                 470                 475                 480 


Lys Gln Asn Ser Arg Ala Leu Glu Ala Gln Lys Glu Lys Glu Lys Lys 
                485                 490                 495     


Leu Lys Ala Arg Lys Glu Arg Leu Arg Leu Gly Lys Leu Glu Lys Gly 
            500                 505                 510         


His Asp Pro Asn Ala Leu Lys Pro Leu Lys Arg Pro Arg Val Arg Arg 
        515                 520                 525             


Ser Lys Leu Phe Tyr Lys Ser Ala Ala Arg Leu Ala Ala Cys Glu Ala 
    530                 535                 540                 


Ile Glu Arg Asp Arg Arg Asp Gly Phe Leu His Arg Val Thr Asn Glu 
545                 550                 555                 560 


Ile Val His Lys Phe Asp Ala Val Ser Val Gln Lys Met Ser Val Ala 
                565                 570                 575     


Pro Met Met Arg Arg Gln Lys Gln Lys Glu Lys Gln Ile Glu Ser Lys 
            580                 585                 590         


Lys Asn Glu Ala Lys Lys Glu Asp Asn Gly Ala Ala Lys Lys Pro Arg 
        595                 600                 605             


Asn Leu Lys Pro Val Arg Lys Leu Leu Arg His Val Ala Met Ala Arg 
    610                 615                 620                 


Gly Arg Gln Phe Leu Glu Tyr Lys Tyr Asn Asp Leu Arg Gly Pro Gly 
625                 630                 635                 640 


Ser Val Leu Ile Ala Asp Arg Leu Glu Pro Glu Val Gln Glu Cys Ser 
                645                 650                 655     


Arg Cys Gly Thr Lys Asn Pro Gln Met Lys Asp Gly Arg Arg Leu Leu 
            660                 665                 670         


Arg Cys Ile Gly Val Leu Pro Asp Gly Thr Asp Cys Asp Ala Val Leu 
        675                 680                 685             


Pro Arg Asn Arg Asn Ala Ala Arg Asn Ala Glu Lys Arg Leu Arg Lys 
    690                 695                 700                 


His Arg Glu Ala His Asn Ala 
705                 710     


<210> 49
<211> 574
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Asn Glu Val Leu Pro Ile Pro Ala Val Gly Glu Asp Ala Ala Asp 
1               5                   10                  15      


Thr Ile Met Arg Gly Ser Lys Met Arg Ile Tyr Pro Ser Val Arg Gln 
            20                  25                  30          


Ala Ala Thr Met Asp Leu Trp Arg Arg Arg Cys Ile Gln Leu Trp Asn 
        35                  40                  45              


Leu Leu Leu Glu Leu Glu Gln Ala Ala Tyr Ser Gly Glu Asn Arg Arg 
    50                  55                  60                  


Thr Gln Ile Gly Trp Arg Ser Ile Trp Ala Thr Val Val Glu Asp Ser 
65                  70                  75                  80  


His Ala Glu Ala Val Arg Val Ala Arg Glu Gly Lys Lys Arg Lys Asp 
                85                  90                  95      


Gly Thr Phe Arg Lys Ala Pro Ser Gly Lys Glu Ile Pro Pro Leu Asp 
            100                 105                 110         


Pro Ala Met Leu Ala Lys Ile Gln Arg Gln Met Asn Gly Ala Val Asp 
        115                 120                 125             


Val Asp Pro Lys Thr Gly Glu Val Thr Pro Ala Gln Pro Arg Leu Phe 
    130                 135                 140                 


Met Trp Glu His Glu Leu Gln Lys Ile Met Ala Arg Leu Lys Gln Ala 
145                 150                 155                 160 


Pro Arg Thr His Trp Ile Asp Asp Leu Pro Ser His Ala Ala Gln Ser 
                165                 170                 175     


Val Val Lys Asp Leu Ile Lys Ala Leu Gln Ala Met Leu Arg Glu Arg 
            180                 185                 190         


Lys Lys Arg Ala Ser Gly Ile Gly Gly Arg Asp Thr Gly Phe Pro Lys 
        195                 200                 205             


Phe Lys Lys Asn Arg Tyr Ala Ala Gly Ser Val Tyr Phe Ala Asn Thr 
    210                 215                 220                 


Gln Leu Arg Phe Glu Ala Lys Arg Gly Lys Ala Gly Asp Pro Asp Ala 
225                 230                 235                 240 


Val Arg Gly Glu Phe Ala Arg Val Lys Leu Pro Asn Gly Val Gly Trp 
                245                 250                 255     


Met Glu Cys Arg Met Pro Arg His Ile Asn Ala Ala His Ala Tyr Ala 
            260                 265                 270         


Gln Ala Thr Leu Met Gly Gly Arg Ile Trp Arg Gln Gly Glu Asn Trp 
        275                 280                 285             


Tyr Leu Ser Cys Gln Trp Lys Met Pro Lys Pro Ala Pro Leu Pro Arg 
    290                 295                 300                 


Ala Gly Arg Thr Ala Ala Ile Lys Ile Ala Ala Ala Ile Pro Ile Thr 
305                 310                 315                 320 


Thr Val Asp Asn Arg Gly Gln Thr Arg Glu Tyr Ala Met Pro Pro Ile 
                325                 330                 335     


Asp Arg Glu Arg Ile Ala Ala His Ala Ala Ala Gly Arg Ala Gln Ser 
            340                 345                 350         


Arg Ala Leu Glu Ala Arg Lys Arg Arg Ala Lys Lys Arg Glu Ala Tyr 
        355                 360                 365             


Ala Lys Lys Arg His Ala Lys Lys Leu Glu Arg Gly Ile Ala Ala Lys 
    370                 375                 380                 


Pro Pro Gly Arg Ala Arg Ile Lys Leu Ser Pro Gly Phe Tyr Ala Ala 
385                 390                 395                 400 


Ala Ala Lys Leu Ala Lys Leu Glu Ala Glu Asp Ala Asn Ala Arg Glu 
                405                 410                 415     


Ala Trp Leu His Glu Ile Thr Thr Gln Ile Val Arg Asn Phe Asp Val 
            420                 425                 430         


Ile Ala Val Pro Arg Met Glu Val Ala Lys Leu Met Lys Lys Pro Glu 
        435                 440                 445             


Pro Pro Glu Glu Lys Glu Glu Gln Val Lys Ala Pro Trp Gln Gly Lys 
    450                 455                 460                 


Arg Arg Ser Leu Lys Ala Ala Arg Val Met Met Arg Arg Thr Ala Met 
465                 470                 475                 480 


Ala Leu Ile Gln Thr Thr Leu Lys Tyr Lys Ala Val Asp Leu Arg Gly 
                485                 490                 495     


Pro Gln Ala Tyr Glu Glu Ile Ala Pro Leu Asp Val Thr Ala Ala Ala 
            500                 505                 510         


Cys Ser Gly Cys Gly Val Leu Lys Pro Glu Trp Lys Met Ala Arg Ala 
        515                 520                 525             


Lys Gly Arg Glu Ile Met Arg Cys Gln Glu Pro Leu Pro Gly Gly Lys 
    530                 535                 540                 


Thr Cys Asn Thr Val Leu Thr Tyr Thr Arg Asn Ser Ala Arg Val Ile 
545                 550                 555                 560 


Gly Arg Glu Leu Ala Val Arg Leu Ala Glu Arg Gln Lys Ala 
                565                 570                 


<210> 50
<211> 400
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Thr Thr Gln Lys Thr Tyr Asn Phe Cys Phe Tyr Asp Gln Arg Phe 
1               5                   10                  15      


Phe Glu Leu Ser Lys Glu Ala Gly Glu Val Tyr Ser Arg Ser Leu Glu 
            20                  25                  30          


Glu Phe Trp Lys Ile Tyr Asp Glu Thr Gly Val Trp Leu Ser Lys Phe 
        35                  40                  45              


Asp Leu Gln Lys His Met Arg Asn Lys Leu Glu Arg Lys Leu Leu His 
    50                  55                  60                  


Ser Asp Ser Phe Leu Gly Ala Met Gln Gln Val His Ala Asn Leu Ala 
65                  70                  75                  80  


Ser Trp Lys Gln Ala Lys Lys Val Val Pro Asp Ala Cys Pro Pro Arg 
                85                  90                  95      


Lys Pro Lys Phe Leu Gln Ala Ile Leu Phe Lys Lys Ser Gln Ile Lys 
            100                 105                 110         


Tyr Lys Asn Gly Phe Leu Arg Leu Thr Leu Gly Thr Glu Lys Glu Phe 
        115                 120                 125             


Leu Tyr Leu Lys Trp Asp Ile Asn Ile Pro Leu Pro Ile Tyr Gly Ser 
    130                 135                 140                 


Val Thr Tyr Ser Lys Thr Arg Gly Trp Lys Ile Asn Leu Cys Leu Glu 
145                 150                 155                 160 


Thr Glu Val Glu Gln Lys Asn Leu Ser Glu Asn Lys Tyr Leu Ser Ile 
                165                 170                 175     


Asp Leu Gly Val Lys Arg Val Ala Thr Ile Phe Asp Gly Glu Asn Thr 
            180                 185                 190         


Ile Thr Leu Ser Gly Lys Lys Phe Met Gly Leu Met His Tyr Arg Asn 
        195                 200                 205             


Lys Leu Asn Gly Lys Thr Gln Ser Arg Leu Ser His Lys Lys Lys Gly 
    210                 215                 220                 


Ser Asn Asn Tyr Lys Lys Ile Gln Arg Ala Lys Arg Lys Thr Thr Asp 
225                 230                 235                 240 


Arg Leu Leu Asn Ile Gln Lys Glu Met Leu His Lys Tyr Ser Ser Phe 
                245                 250                 255     


Ile Val Asn Tyr Ala Ile Arg Asn Asp Ile Gly Asn Ile Ile Ile Gly 
            260                 265                 270         


Asp Asn Ser Ser Thr His Asp Ser Pro Asn Met Arg Gly Lys Thr Asn 
        275                 280                 285             


Gln Lys Ile Ser Gln Asn Pro Glu Gln Lys Leu Lys Asn Tyr Ile Lys 
    290                 295                 300                 


Tyr Lys Phe Glu Ser Ile Ser Gly Arg Val Asp Ile Val Pro Glu Pro 
305                 310                 315                 320 


Tyr Thr Ser Arg Lys Cys Pro His Cys Lys Asn Ile Lys Lys Ser Ser 
                325                 330                 335     


Pro Lys Gly Arg Thr Tyr Lys Cys Lys Lys Cys Gly Phe Ile Phe Asp 
            340                 345                 350         


Arg Asp Gly Val Gly Ala Ile Asn Ile Tyr Asn Glu Asn Val Ser Phe 
        355                 360                 365             


Gly Gln Ile Ile Ser Pro Gly Arg Ile Arg Ser Leu Thr Glu Pro Ile 
    370                 375                 380                 


Gly Met Lys Phe His Asn Glu Ile Tyr Phe Lys Ser Tyr Val Ala Ala 
385                 390                 395                 400 


<210> 51
<211> 743
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Met Ser Val Arg Ser Phe Gln Ala Arg Val Glu Cys Asp Lys Gln Thr 
1               5                   10                  15      


Met Glu His Leu Trp Arg Thr His Lys Val Phe Asn Glu Arg Leu Pro 
            20                  25                  30          


Glu Ile Ile Lys Ile Leu Phe Lys Met Lys Arg Gly Glu Cys Gly Gln 
        35                  40                  45              


Asn Asp Lys Gln Lys Ser Leu Tyr Lys Ser Ile Ser Gln Ser Ile Leu 
    50                  55                  60                  


Glu Ala Asn Ala Gln Asn Ala Asp Tyr Leu Leu Asn Ser Val Ser Ile 
65                  70                  75                  80  


Lys Gly Trp Lys Pro Gly Thr Ala Lys Lys Tyr Arg Asn Ala Ser Phe 
                85                  90                  95      


Thr Trp Ala Asp Asp Ala Ala Lys Leu Ser Ser Gln Gly Ile His Val 
            100                 105                 110         


Tyr Asp Lys Lys Gln Val Leu Gly Asp Leu Pro Gly Met Met Ser Gln 
        115                 120                 125             


Met Val Cys Arg Gln Ser Val Glu Ala Ile Ser Gly His Ile Glu Leu 
    130                 135                 140                 


Thr Lys Lys Trp Glu Lys Glu His Asn Glu Trp Leu Lys Glu Lys Glu 
145                 150                 155                 160 


Lys Trp Glu Ser Glu Asp Glu His Lys Lys Tyr Leu Asp Leu Arg Glu 
                165                 170                 175     


Lys Phe Glu Gln Phe Glu Gln Ser Ile Gly Gly Lys Ile Thr Lys Arg 
            180                 185                 190         


Arg Gly Arg Trp His Leu Tyr Leu Lys Trp Leu Ser Asp Asn Pro Asp 
        195                 200                 205             


Phe Ala Ala Trp Arg Gly Asn Lys Ala Val Ile Asn Pro Leu Ser Glu 
    210                 215                 220                 


Lys Ala Gln Ile Arg Ile Asn Lys Ala Lys Pro Asn Lys Lys Asn Ser 
225                 230                 235                 240 


Val Glu Arg Asp Glu Phe Phe Lys Ala Asn Pro Glu Met Lys Ala Leu 
                245                 250                 255     


Asp Asn Leu His Gly Tyr Tyr Glu Arg Asn Phe Val Arg Arg Arg Lys 
            260                 265                 270         


Thr Lys Lys Asn Pro Asp Gly Phe Asp His Lys Pro Thr Phe Thr Leu 
        275                 280                 285             


Pro His Pro Thr Ile His Pro Arg Trp Phe Val Phe Asn Lys Pro Lys 
    290                 295                 300                 


Thr Asn Pro Glu Gly Tyr Arg Lys Leu Ile Leu Pro Lys Lys Ala Gly 
305                 310                 315                 320 


Asp Leu Gly Ser Leu Glu Met Arg Leu Leu Thr Gly Glu Lys Asn Lys 
                325                 330                 335     


Gly Asn Tyr Pro Asp Asp Trp Ile Ser Val Lys Phe Lys Ala Asp Pro 
            340                 345                 350         


Arg Leu Ser Leu Ile Arg Pro Val Lys Gly Arg Arg Val Val Arg Lys 
        355                 360                 365             


Gly Lys Glu Gln Gly Gln Thr Lys Glu Thr Asp Ser Tyr Glu Phe Phe 
    370                 375                 380                 


Asp Lys His Leu Lys Lys Trp Arg Pro Ala Lys Leu Ser Gly Val Lys 
385                 390                 395                 400 


Leu Ile Phe Pro Asp Lys Thr Pro Lys Ala Ala Tyr Leu Tyr Phe Thr 
                405                 410                 415     


Cys Asp Ile Pro Asp Glu Pro Leu Thr Glu Thr Ala Lys Lys Ile Gln 
            420                 425                 430         


Trp Leu Glu Thr Gly Asp Val Thr Lys Lys Gly Lys Lys Arg Lys Lys 
        435                 440                 445             


Lys Val Leu Pro His Gly Leu Val Ser Cys Ala Val Asp Leu Ser Met 
    450                 455                 460                 


Arg Arg Gly Thr Thr Gly Phe Ala Thr Leu Cys Arg Tyr Glu Asn Gly 
465                 470                 475                 480 


Lys Ile His Ile Leu Arg Ser Arg Asn Leu Trp Val Gly Tyr Lys Glu 
                485                 490                 495     


Gly Lys Gly Cys His Pro Tyr Arg Trp Thr Glu Gly Pro Asp Leu Gly 
            500                 505                 510         


His Ile Ala Lys His Lys Arg Glu Ile Arg Ile Leu Arg Ser Lys Arg 
        515                 520                 525             


Gly Lys Pro Val Lys Gly Glu Glu Ser His Ile Asp Leu Gln Lys His 
    530                 535                 540                 


Ile Asp Tyr Met Gly Glu Asp Arg Phe Lys Lys Ala Ala Arg Thr Ile 
545                 550                 555                 560 


Val Asn Phe Ala Leu Asn Thr Glu Asn Ala Ala Ser Lys Asn Gly Phe 
                565                 570                 575     


Tyr Pro Arg Ala Asp Val Leu Leu Leu Glu Asn Leu Glu Gly Leu Ile 
            580                 585                 590         


Pro Asp Ala Glu Lys Glu Arg Gly Ile Asn Arg Ala Leu Ala Gly Trp 
        595                 600                 605             


Asn Arg Arg His Leu Val Glu Arg Val Ile Glu Met Ala Lys Asp Ala 
    610                 615                 620                 


Gly Phe Lys Arg Arg Val Phe Glu Ile Pro Pro Tyr Gly Thr Ser Gln 
625                 630                 635                 640 


Val Cys Ser Lys Cys Gly Ala Leu Gly Arg Arg Tyr Ser Ile Ile Arg 
                645                 650                 655     


Glu Asn Asn Arg Arg Glu Ile Arg Phe Gly Tyr Val Glu Lys Leu Phe 
            660                 665                 670         


Ala Cys Pro Asn Cys Gly Tyr Cys Ala Asn Ala Asp His Asn Ala Ser 
        675                 680                 685             


Val Asn Leu Asn Arg Arg Phe Leu Ile Glu Asp Ser Phe Lys Ser Tyr 
    690                 695                 700                 


Tyr Asp Trp Lys Arg Leu Ser Glu Lys Lys Gln Lys Glu Glu Ile Glu 
705                 710                 715                 720 


Thr Ile Glu Ser Lys Leu Met Asp Lys Leu Cys Ala Met His Lys Ile 
                725                 730                 735     


Ser Arg Gly Ser Ile Ser Lys 
            740             


<210> 52
<211> 769
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met His Leu Trp Arg Thr His Cys Val Phe Asn Gln Arg Leu Pro Ala 
1               5                   10                  15      


Leu Leu Lys Arg Leu Phe Ala Met Arg Arg Gly Glu Val Gly Gly Asn 
            20                  25                  30          


Glu Ala Gln Arg Gln Val Tyr Gln Arg Val Ala Gln Phe Val Leu Ala 
        35                  40                  45              


Arg Asp Ala Lys Asp Ser Val Asp Leu Leu Asn Ala Val Ser Leu Arg 
    50                  55                  60                  


Lys Arg Ser Ala Asn Ser Ala Phe Lys Lys Lys Ala Thr Ile Ser Cys 
65                  70                  75                  80  


Asn Gly Gln Ala Arg Glu Val Thr Gly Glu Glu Val Phe Ala Glu Ala 
                85                  90                  95      


Val Ala Leu Ala Ser Lys Gly Val Phe Ala Tyr Asp Lys Asp Asp Met 
            100                 105                 110         


Arg Ala Gly Leu Pro Asp Ser Leu Phe Gln Pro Leu Thr Arg Asp Ala 
        115                 120                 125             


Val Ala Cys Met Arg Ser His Glu Glu Leu Val Ala Thr Trp Lys Lys 
    130                 135                 140                 


Glu Tyr Arg Glu Trp Arg Asp Arg Lys Ser Glu Trp Glu Ala Glu Pro 
145                 150                 155                 160 


Glu His Ala Leu Tyr Leu Asn Leu Arg Pro Lys Phe Glu Glu Gly Glu 
                165                 170                 175     


Ala Ala Arg Gly Gly Arg Phe Arg Lys Arg Ala Glu Arg Asp His Ala 
            180                 185                 190         


Tyr Leu Asp Trp Leu Glu Ala Asn Pro Gln Leu Ala Ala Trp Arg Arg 
        195                 200                 205             


Lys Ala Pro Pro Ala Val Val Pro Ile Asp Glu Ala Gly Lys Arg Arg 
    210                 215                 220                 


Ile Ala Arg Ala Lys Ala Trp Lys Gln Ala Ser Val Arg Ala Glu Glu 
225                 230                 235                 240 


Phe Trp Lys Arg Asn Pro Glu Leu His Ala Leu His Lys Ile His Val 
                245                 250                 255     


Gln Tyr Leu Arg Glu Phe Val Arg Pro Arg Arg Thr Arg Arg Asn Lys 
            260                 265                 270         


Arg Arg Glu Gly Phe Lys Gln Arg Pro Thr Phe Thr Met Pro Asp Pro 
        275                 280                 285             


Val Arg His Pro Arg Trp Cys Leu Phe Asn Ala Pro Gln Thr Ser Pro 
    290                 295                 300                 


Gln Gly Tyr Arg Leu Leu Arg Leu Pro Gln Ser Arg Arg Thr Val Gly 
305                 310                 315                 320 


Ser Val Glu Leu Arg Leu Leu Thr Gly Pro Ser Asp Gly Ala Gly Phe 
                325                 330                 335     


Pro Asp Ala Trp Val Asn Val Arg Phe Lys Ala Asp Pro Arg Leu Ala 
            340                 345                 350         


Gln Leu Arg Pro Val Lys Val Pro Arg Thr Val Thr Arg Gly Lys Asn 
        355                 360                 365             


Lys Gly Ala Lys Val Glu Ala Asp Gly Phe Arg Tyr Tyr Asp Asp Gln 
    370                 375                 380                 


Leu Leu Ile Glu Arg Asp Ala Gln Val Ser Gly Val Lys Leu Leu Phe 
385                 390                 395                 400 


Arg Asp Ile Arg Met Ala Pro Phe Ala Asp Lys Pro Ile Glu Asp Arg 
                405                 410                 415     


Leu Leu Ser Ala Thr Pro Tyr Leu Val Phe Ala Val Glu Ile Lys Asp 
            420                 425                 430         


Glu Ala Arg Thr Glu Arg Ala Lys Ala Ile Arg Phe Asp Glu Thr Ser 
        435                 440                 445             


Glu Leu Thr Lys Ser Gly Lys Lys Arg Lys Thr Leu Pro Ala Gly Leu 
    450                 455                 460                 


Val Ser Val Ala Val Asp Leu Asp Thr Arg Gly Val Gly Phe Leu Thr 
465                 470                 475                 480 


Arg Ala Val Ile Gly Val Pro Glu Ile Gln Gln Thr His His Gly Val 
                485                 490                 495     


Arg Leu Leu Gln Ser Arg Tyr Val Ala Val Gly Gln Val Glu Ala Arg 
            500                 505                 510         


Ala Ser Gly Glu Ala Glu Trp Ser Pro Gly Pro Asp Leu Ala His Ile 
        515                 520                 525             


Ala Arg His Lys Arg Glu Ile Arg Arg Leu Arg Gln Leu Arg Gly Lys 
    530                 535                 540                 


Pro Val Lys Gly Glu Arg Ser His Val Arg Leu Gln Ala His Ile Asp 
545                 550                 555                 560 


Arg Met Gly Glu Asp Arg Phe Lys Lys Ala Ala Arg Lys Ile Val Asn 
                565                 570                 575     


Glu Ala Leu Arg Gly Ser Asn Pro Ala Ala Gly Asp Pro Tyr Thr Arg 
            580                 585                 590         


Ala Asp Val Leu Leu Tyr Glu Ser Leu Glu Thr Leu Leu Pro Asp Ala 
        595                 600                 605             


Glu Arg Glu Arg Gly Ile Asn Arg Ala Leu Leu Arg Trp Asn Arg Ala 
    610                 615                 620                 


Lys Leu Ile Glu His Leu Lys Arg Met Cys Asp Asp Ala Gly Ile Arg 
625                 630                 635                 640 


His Phe Pro Val Ser Pro Phe Gly Thr Ser Gln Val Cys Ser Lys Cys 
                645                 650                 655     


Gly Ala Leu Gly Arg Arg Tyr Ser Leu Ala Arg Glu Asn Gly Arg Ala 
            660                 665                 670         


Val Ile Arg Phe Gly Trp Val Glu Arg Leu Phe Ala Cys Pro Asn Pro 
        675                 680                 685             


Glu Cys Pro Gly Arg Arg Pro Asp Arg Pro Asp Arg Pro Phe Thr Cys 
    690                 695                 700                 


Asn Ser Asp His Asn Ala Ser Val Asn Leu His Arg Val Phe Ala Leu 
705                 710                 715                 720 


Gly Asp Gln Ala Val Ala Ala Phe Arg Ala Leu Ala Pro Arg Asp Ser 
                725                 730                 735     


Pro Ala Arg Thr Leu Ala Val Lys Arg Val Glu Asp Thr Leu Arg Pro 
            740                 745                 750         


Gln Leu Met Arg Val His Lys Leu Ala Asp Ala Gly Val Asp Ser Pro 
        755                 760                 765             


Phe 
    


<210> 53
<211> 666
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Ala Thr Leu Val Tyr Arg Tyr Gly Val Arg Ala His Gly Ser Ala 
1               5                   10                  15      


Arg Gln Gln Asp Ala Val Val Ser Asp Pro Ala Met Leu Glu Gln Leu 
            20                  25                  30          


Arg Leu Gly His Glu Leu Arg Asn Ala Leu Val Gly Val Gln His Arg 
        35                  40                  45              


Tyr Glu Asp Gly Lys Arg Ala Val Trp Ser Gly Phe Ala Ser Val Ala 
    50                  55                  60                  


Ala Ala Asp His Arg Val Thr Thr Gly Glu Thr Ala Val Ala Glu Leu 
65                  70                  75                  80  


Glu Lys Gln Ala Arg Ala Glu His Ser Ala Asp Arg Thr Ala Ala Thr 
                85                  90                  95      


Arg Gln Gly Thr Ala Glu Ser Leu Lys Ala Ala Arg Ala Ala Val Lys 
            100                 105                 110         


Gln Ala Arg Ala Asp Arg Lys Ala Ala Met Ala Ala Val Ala Glu Gln 
        115                 120                 125             


Ala Lys Pro Lys Ile Gln Ala Leu Gly Asp Asp Arg Asp Ala Glu Ile 
    130                 135                 140                 


Lys Asp Leu Tyr Arg Arg Phe Cys Gln Asp Gly Val Leu Leu Pro Arg 
145                 150                 155                 160 


Cys Gly Arg Cys Ala Gly Asp Leu Arg Ser Asp Gly Asp Cys Thr Asp 
                165                 170                 175     


Cys Gly Ala Ala His Glu Pro Arg Lys Leu Tyr Trp Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ile Arg Glu Asp His Gln Thr Ala Val Lys Leu Val Glu Ala Lys 
        195                 200                 205             


Arg Lys Ala Gly Gln Pro Ala Arg Leu Arg Phe Arg Arg Trp Thr Gly 
    210                 215                 220                 


Asp Gly Thr Leu Thr Val Gln Leu Gln Arg Met His Gly Pro Ala Cys 
225                 230                 235                 240 


Arg Cys Val Thr Cys Ala Glu Lys Leu Thr Arg Arg Ala Arg Lys Thr 
                245                 250                 255     


Asp Pro Gln Ala Pro Ala Val Ala Ala Asp Pro Ala Tyr Pro Pro Thr 
            260                 265                 270         


Asp Pro Pro Arg Asp Pro Ala Leu Leu Ala Ser Gly Gln Gly Lys Trp 
        275                 280                 285             


Arg Asn Val Leu Gln Leu Gly Thr Trp Ile Pro Pro Gly Glu Trp Ser 
    290                 295                 300                 


Ala Met Ser Arg Ala Glu Arg Arg Arg Val Gly Arg Ser His Ile Gly 
305                 310                 315                 320 


Trp Gln Leu Gly Gly Gly Arg Gln Leu Thr Leu Pro Val Gln Leu His 
                325                 330                 335     


Arg Gln Met Pro Ala Asp Ala Asp Val Ala Met Ala Gln Leu Thr Arg 
            340                 345                 350         


Val Arg Val Gly Gly Arg His Arg Met Ser Val Ala Leu Thr Ala Lys 
        355                 360                 365             


Leu Pro Asp Pro Pro Gln Val Gln Gly Leu Pro Pro Val Ala Leu His 
    370                 375                 380                 


Leu Gly Trp Arg Gln Arg Pro Asp Gly Ser Leu Arg Val Ala Thr Trp 
385                 390                 395                 400 


Ala Cys Pro Gln Pro Leu Asp Leu Pro Pro Ala Val Ala Asp Val Val 
                405                 410                 415     


Val Ser His Gly Gly Arg Trp Gly Glu Val Ile Met Pro Ala Arg Trp 
            420                 425                 430         


Leu Ala Asp Ala Glu Val Pro Pro Arg Leu Leu Gly Arg Arg Asp Lys 
        435                 440                 445             


Ala Met Glu Pro Val Leu Glu Ala Leu Ala Asp Trp Leu Glu Ala His 
    450                 455                 460                 


Thr Glu Ala Cys Thr Ala Arg Met Thr Pro Ala Leu Val Arg Arg Trp 
465                 470                 475                 480 


Arg Ser Gln Gly Arg Leu Ala Gly Leu Thr Asn Arg Trp Arg Gly Gln 
                485                 490                 495     


Pro Pro Thr Gly Ser Ala Glu Ile Leu Thr Tyr Leu Glu Ala Trp Arg 
            500                 505                 510         


Ile Gln Asp Lys Leu Leu Trp Glu Arg Glu Ser His Leu Arg Arg Arg 
        515                 520                 525             


Leu Ala Ala Arg Arg Asp Asp Ala Trp Arg Arg Val Ala Ser Trp Leu 
    530                 535                 540                 


Ala Arg His Ala Gly Val Leu Val Val Asp Asp Ala Asp Ile Ala Glu 
545                 550                 555                 560 


Leu Arg Arg Arg Asp Asp Pro Ala Asp Thr Asp Pro Thr Met Pro Ala 
                565                 570                 575     


Ser Ala Ala Gln Ala Ala Arg Ala Arg Ala Ala Leu Ala Ala Pro Gly 
            580                 585                 590         


Arg Leu Arg His Leu Ala Thr Ile Thr Ala Thr Arg Asp Gly Leu Gly 
        595                 600                 605             


Val His Thr Val Ala Ser Ala Gly Leu Thr Arg Leu His Arg Lys Cys 
    610                 615                 620                 


Gly His Gln Ala Gln Pro Asp Pro Arg Tyr Ala Ala Ser Ala Val Val 
625                 630                 635                 640 


Thr Cys Pro Gly Cys Gly Asn Gly Tyr Asp Gln Asp Tyr Asn Ala Ala 
                645                 650                 655     


Met Leu Met Leu Asp Arg Gln Gln Gln Pro 
            660                 665     


<210> 54
<211> 564
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Met Ser Arg Val Glu Leu His Arg Ala Tyr Lys Phe Arg Leu Tyr Pro 
1               5                   10                  15      


Thr Pro Ala Gln Val Ala Glu Leu Ala Glu Trp Glu Arg Gln Leu Arg 
            20                  25                  30          


Arg Leu Tyr Asn Leu Ala His Ser Gln Arg Leu Ala Ala Met Gln Arg 
        35                  40                  45              


His Val Arg Pro Lys Ser Pro Gly Val Leu Lys Ser Glu Cys Leu Ser 
    50                  55                  60                  


Cys Gly Ala Val Ala Val Ala Glu Ile Gly Thr Asp Gly Lys Ala Lys 
65                  70                  75                  80  


Lys Thr Val Lys His Ala Val Gly Cys Ser Val Leu Glu Cys Arg Ser 
                85                  90                  95      


Cys Gly Gly Ser Pro Asp Ala Glu Gly Arg Thr Ala His Thr Ala Ala 
            100                 105                 110         


Cys Ser Phe Val Asp Tyr Tyr Arg Gln Gly Arg Glu Met Thr Gln Leu 
        115                 120                 125             


Leu Glu Glu Asp Asp Gln Leu Ala Arg Val Val Cys Ser Ala Arg Gln 
    130                 135                 140                 


Glu Thr Leu Arg Asp Leu Glu Lys Ala Trp Gln Arg Trp His Lys Met 
145                 150                 155                 160 


Pro Gly Phe Gly Lys Pro His Phe Lys Lys Arg Ile Asp Ser Cys Arg 
                165                 170                 175     


Ile Tyr Phe Ser Thr Pro Lys Ser Trp Ala Val Asp Leu Gly Tyr Leu 
            180                 185                 190         


Ser Phe Thr Gly Val Ala Ser Ser Val Gly Arg Ile Lys Ile Arg Gln 
        195                 200                 205             


Asp Arg Val Trp Pro Gly Asp Ala Lys Phe Ser Ser Cys His Val Val 
    210                 215                 220                 


Arg Asp Val Asp Glu Trp Tyr Ala Val Phe Pro Leu Thr Phe Thr Lys 
225                 230                 235                 240 


Glu Ile Glu Lys Pro Lys Gly Gly Ala Val Gly Ile Asn Arg Gly Ala 
                245                 250                 255     


Val His Ala Ile Ala Asp Ser Thr Gly Arg Val Val Asp Ser Pro Lys 
            260                 265                 270         


Phe Tyr Ala Arg Ser Leu Gly Val Ile Arg His Arg Ala Arg Leu Leu 
        275                 280                 285             


Asp Arg Lys Val Pro Phe Gly Arg Ala Val Lys Pro Ser Pro Thr Lys 
    290                 295                 300                 


Tyr His Gly Leu Pro Lys Ala Asp Ile Asp Ala Ala Ala Ala Arg Val 
305                 310                 315                 320 


Asn Ala Ser Pro Gly Arg Leu Val Tyr Glu Ala Arg Ala Arg Gly Ser 
                325                 330                 335     


Ile Ala Ala Ala Glu Ala His Leu Ala Ala Leu Val Leu Pro Ala Pro 
            340                 345                 350         


Arg Gln Thr Ser Gln Leu Pro Ser Glu Gly Arg Asn Arg Glu Arg Ala 
        355                 360                 365             


Arg Arg Phe Leu Ala Leu Ala His Gln Arg Val Arg Arg Gln Arg Glu 
    370                 375                 380                 


Trp Phe Leu His Asn Glu Ser Ala His Tyr Ala Gln Ser Tyr Thr Lys 
385                 390                 395                 400 


Ile Ala Ile Glu Asp Trp Ser Thr Lys Glu Met Thr Ser Ser Glu Pro 
                405                 410                 415     


Arg Asp Ala Glu Glu Met Lys Arg Val Thr Arg Ala Arg Asn Arg Ser 
            420                 425                 430         


Ile Leu Asp Val Gly Trp Tyr Glu Leu Gly Arg Gln Ile Ala Tyr Lys 
        435                 440                 445             


Ser Glu Ala Thr Gly Ala Glu Phe Ala Lys Val Asp Pro Gly Leu Arg 
    450                 455                 460                 


Glu Thr Glu Thr His Val Pro Glu Ala Ile Val Arg Glu Arg Asp Val 
465                 470                 475                 480 


Asp Val Ser Gly Met Leu Arg Gly Glu Ala Gly Ile Ser Gly Thr Cys 
                485                 490                 495     


Ser Arg Cys Gly Gly Leu Leu Arg Ala Ser Ala Ser Gly His Ala Asp 
            500                 505                 510         


Ala Glu Cys Glu Val Cys Leu His Val Glu Val Gly Asp Val Asn Ala 
        515                 520                 525             


Ala Val Asn Val Leu Lys Arg Ala Met Phe Pro Gly Ala Ala Pro Pro 
    530                 535                 540                 


Ser Lys Glu Lys Ala Lys Val Thr Ile Gly Ile Lys Gly Arg Lys Lys 
545                 550                 555                 560 


Lys Arg Ala Ala 
                


<210> 55
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Met Ser Arg Val Glu Leu His Arg Ala Tyr Lys Phe Arg Leu Tyr Pro 
1               5                   10                  15      


Thr Pro Val Gln Val Ala Glu Leu Ser Glu Trp Glu Arg Gln Leu Arg 
            20                  25                  30          


Arg Leu Tyr Asn Leu Gly His Glu Gln Arg Leu Leu Thr Leu Thr Arg 
        35                  40                  45              


His Leu Arg Pro Lys Ser Pro Gly Val Leu Lys Gly Glu Cys Leu Ser 
    50                  55                  60                  


Cys Asp Ser Thr Gln Val Gln Glu Val Gly Ala Asp Gly Arg Pro Lys 
65                  70                  75                  80  


Thr Thr Val Arg His Ala Glu Gln Cys Pro Thr Leu Ala Cys Arg Ser 
                85                  90                  95      


Cys Gly Ala Leu Arg Asp Ala Glu Gly Arg Thr Ala His Thr Val Ala 
            100                 105                 110         


Cys Ala Phe Val Asp Tyr Tyr Arg Gln Gly Arg Glu Met Thr Glu Leu 
        115                 120                 125             


Leu Ala Ala Asp Asp Gln Leu Ala Arg Val Val Cys Ser Ala Arg Gln 
    130                 135                 140                 


Glu Val Leu Arg Asp Leu Asp Lys Ala Trp Gln Arg Trp Arg Lys Met 
145                 150                 155                 160 


Pro Gly Phe Gly Lys Pro Arg Phe Lys Arg Arg Thr Asp Ser Cys Arg 
                165                 170                 175     


Ile Tyr Phe Ser Thr Pro Lys Ala Trp Lys Leu Glu Gly Gly His Leu 
            180                 185                 190         


Ser Phe Thr Gly Ala Ala Thr Thr Val Gly Ala Ile Lys Met Arg Gln 
        195                 200                 205             


Asp Arg Asn Trp Pro Ala Ser Val Gln Phe Ser Ser Cys His Val Val 
    210                 215                 220                 


Arg Asp Val Asp Glu Trp Tyr Ala Val Phe Pro Leu Thr Phe Val Ala 
225                 230                 235                 240 


Glu Val Ala Arg Pro Lys Gly Gly Ala Val Gly Ile Asn Arg Gly Ala 
                245                 250                 255     


Val His Ala Ile Ala Asp Ser Thr Gly Arg Val Val Asp Ser Pro Arg 
            260                 265                 270         


Tyr Tyr Ala Arg Ala Leu Gly Val Ile Arg His Arg Ala Arg Leu Phe 
        275                 280                 285             


Asp Arg Lys Val Pro Ser Gly His Ala Val Lys Pro Ser Pro Thr Lys 
    290                 295                 300                 


Tyr Arg Gly Leu Ser Ala Ile Glu Val Asp Arg Val Ala Arg Ala Thr 
305                 310                 315                 320 


Gly Phe Thr Pro Gly Arg Val Val Thr Glu Ala Leu Asn Arg Gly Gly 
                325                 330                 335     


Val Ala Tyr Ala Glu Cys Ala Leu Ala Ala Ile Ala Val Leu Gly His 
            340                 345                 350         


Gly Pro Glu Arg Pro Leu Thr Ser Asp Gly Arg Asn Arg Glu Lys Ala 
        355                 360                 365             


Arg Lys Phe Leu Ala Leu Ala His Gln Arg Val Arg Arg Gln Arg Glu 
    370                 375                 380                 


Trp Phe Leu His Asn Glu Ser Ala His Tyr Ala Arg Thr Tyr Ser Lys 
385                 390                 395                 400 


Ile Ala Ile Glu Asp Trp Ser Thr Lys Glu Met Thr Ala Ser Glu Pro 
                405                 410                 415     


Gln Gly Glu Glu Thr Arg Arg Val Thr Arg Ser Arg Asn Arg Ser Ile 
            420                 425                 430         


Leu Asp Val Gly Trp Tyr Glu Leu Gly Arg Gln Leu Ala Tyr Lys Thr 
        435                 440                 445             


Glu Ala Thr Gly Ala Glu Phe Ala Gln Val Asp Pro Gly Leu Lys Glu 
    450                 455                 460                 


Thr Glu Thr Asn Val Pro Lys Ala Ile Ala Asp Ala Arg Asp Val Asp 
465                 470                 475                 480 


Val Ser Gly Met Leu Arg Gly Glu Ala Gly Ile Ser Gly Thr Cys Ser 
                485                 490                 495     


Lys Cys Gly Gly Leu Leu Arg Ala Pro Ala Ser Gly His Ala Asp Ala 
            500                 505                 510         


Glu Cys Glu Ile Cys Leu Asn Val Glu Val Gly Asp Val Asn Ala Ala 
        515                 520                 525             


Val Asn Val Leu Lys Arg Ala Met Phe Pro Gly Asp Ala Pro Pro Ala 
    530                 535                 540                 


Ser Gly Glu Lys Pro Lys Val Ser Ile Gly Ile Lys Gly Arg Gln Lys 
545                 550                 555                 560 


Lys Lys Lys Ala Ala 
                565 


<210> 56
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met Glu Ala Ile Ala Thr Gly Met Ser Pro Glu Arg Arg Val Glu Leu 
1               5                   10                  15      


Gly Ile Leu Pro Gly Ser Val Glu Leu Lys Arg Ala Tyr Lys Phe Arg 
            20                  25                  30          


Leu Tyr Pro Met Lys Val Gln Gln Ala Glu Leu Ser Glu Trp Glu Arg 
        35                  40                  45              


Gln Leu Arg Arg Leu Tyr Asn Leu Ala His Glu Gln Arg Leu Ala Ala 
    50                  55                  60                  


Leu Leu Arg Tyr Arg Asp Trp Asp Phe Gln Lys Gly Ala Cys Pro Ser 
65                  70                  75                  80  


Cys Arg Val Ala Val Pro Gly Val His Thr Ala Ala Cys Asp His Val 
                85                  90                  95      


Asp Tyr Phe Arg Gln Ala Arg Glu Met Thr Gln Leu Leu Glu Val Asp 
            100                 105                 110         


Ala Gln Leu Ser Arg Val Ile Cys Cys Ala Arg Gln Glu Val Leu Arg 
        115                 120                 125             


Asp Leu Asp Lys Ala Trp Gln Arg Trp Arg Lys Lys Leu Gly Gly Arg 
    130                 135                 140                 


Pro Arg Phe Lys Arg Arg Thr Asp Ser Cys Arg Ile Tyr Leu Ser Thr 
145                 150                 155                 160 


Pro Lys His Trp Glu Ile Ala Gly Arg Tyr Leu Arg Leu Ser Gly Leu 
                165                 170                 175     


Ala Ser Ser Val Gly Glu Ile Arg Ile Glu Gln Asp Arg Ala Phe Pro 
            180                 185                 190         


Glu Gly Ala Leu Leu Ser Ser Cys Ser Ile Val Arg Asp Val Asp Glu 
        195                 200                 205             


Trp Tyr Ala Cys Leu Pro Leu Thr Phe Thr Gln Pro Ile Glu Arg Ala 
    210                 215                 220                 


Pro His Arg Ser Val Gly Leu Asn Arg Gly Val Val His Ala Leu Ala 
225                 230                 235                 240 


Asp Ser Asp Gly Arg Val Val Asp Ser Pro Lys Phe Phe Glu Arg Ala 
                245                 250                 255     


Leu Ala Thr Val Gln Lys Arg Ser Arg Asp Leu Ala Arg Lys Val Ser 
            260                 265                 270         


Gly Ser Arg Asn Ala His Lys Ala Arg Ile Lys Leu Ala Lys Ala His 
        275                 280                 285             


Gln Arg Val Arg Arg Gln Arg Ala Ala Phe Leu His Gln Glu Ser Ala 
    290                 295                 300                 


Tyr Tyr Ser Lys Gly Phe Asp Leu Val Ala Leu Glu Asp Met Ser Val 
305                 310                 315                 320 


Arg Lys Met Thr Ala Thr Ala Gly Glu Ala Pro Glu Met Gly Arg Gly 
                325                 330                 335     


Ala Gln Arg Asp Leu Asn Arg Gly Ile Leu Asp Val Gly Trp Tyr Glu 
            340                 345                 350         


Leu Ala Arg Gln Ile Asp Tyr Lys Arg Leu Ala His Gly Gly Glu Leu 
        355                 360                 365             


Leu Arg Val Asp Pro Gly Gln Thr Thr Pro Leu Ala Cys Val Thr Glu 
    370                 375                 380                 


Glu Gln Pro Ala Arg Gly Ile Ser Ser Ala Cys Ala Val Cys Gly Ile 
385                 390                 395                 400 


Pro Leu Ala Arg Pro Ala Ser Gly Asn Ala Arg Met Arg Cys Thr Ala 
                405                 410                 415     


Cys Gly Ser Ser Gln Val Gly Asp Val Asn Ala Ala Glu Asn Val Leu 
            420                 425                 430         


Thr Arg Ala Leu Ser Ser Ala Pro Ser Gly Pro Lys Ser Pro Lys Ala 
        435                 440                 445             


Ser Ile Lys Ile Lys Gly Arg Gln Lys Arg Leu Gly Thr Pro Ala Asn 
    450                 455                 460                 


Arg Ala Gly Glu Ala Ser Gly Gly Asp Pro Pro Val Arg Gly Pro Val 
465                 470                 475                 480 


Glu Gly Gly Thr Leu Ala Tyr Val Val Glu Pro Val Ser Glu Ser Gln 
                485                 490                 495     


Ser Asp Thr 
            


<210> 57
<211> 560
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Met Thr Val Arg Thr Tyr Lys Tyr Arg Ala Tyr Pro Thr Pro Glu Gln 
1               5                   10                  15      


Ala Glu Ala Leu Thr Ser Trp Leu Arg Phe Ala Ser Gln Leu Tyr Asn 
            20                  25                  30          


Ala Ala Leu Glu His Arg Lys Asn Ala Trp Gly Arg His Asp Ala His 
        35                  40                  45              


Gly Arg Gly Phe Arg Phe Trp Asp Gly Asp Ala Ala Pro Arg Lys Lys 
    50                  55                  60                  


Ser Asp Pro Pro Gly Arg Trp Val Tyr Arg Gly Gly Gly Gly Ala His 
65                  70                  75                  80  


Ile Ser Lys Asn Asp Gln Gly Lys Leu Leu Thr Glu Phe Arg Arg Glu 
                85                  90                  95      


His Ala Glu Leu Leu Pro Pro Gly Met Pro Ala Leu Val Gln His Glu 
            100                 105                 110         


Val Leu Ala Arg Leu Glu Arg Ser Met Ala Ala Phe Phe Gln Arg Ala 
        115                 120                 125             


Thr Lys Gly Gln Lys Ala Gly Tyr Pro Arg Trp Arg Ser Glu His Arg 
    130                 135                 140                 


Tyr Asp Ser Leu Thr Phe Gly Leu Thr Ser Pro Ser Lys Glu Arg Phe 
145                 150                 155                 160 


Asp Pro Glu Thr Gly Glu Ser Leu Gly Arg Gly Lys Thr Val Gly Ala 
                165                 170                 175     


Gly Thr Tyr His Asn Gly Asp Leu Arg Leu Thr Gly Leu Gly Glu Leu 
            180                 185                 190         


Arg Ile Leu Glu His Arg Arg Ile Pro Met Gly Ala Ile Pro Lys Ser 
        195                 200                 205             


Val Ile Val Arg Arg Ser Gly Lys Arg Trp Phe Val Ser Ile Ala Met 
    210                 215                 220                 


Glu Met Pro Ser Val Glu Pro Ala Ala Ser Gly Arg Pro Ala Val Gly 
225                 230                 235                 240 


Leu Asp Met Gly Val Val Thr Trp Gly Thr Ala Phe Thr Ala Asp Thr 
                245                 250                 255     


Ser Ala Ala Ala Ala Leu Val Ala Asp Leu Arg Arg Met Ala Thr Asp 
            260                 265                 270         


Pro Ser Asp Cys Arg Arg Leu Glu Glu Leu Glu Arg Glu Ala Ala Gln 
        275                 280                 285             


Leu Ser Glu Val Leu Ala His Cys Arg Ala Arg Gly Leu Asp Pro Ala 
    290                 295                 300                 


Arg Pro Arg Arg Cys Pro Lys Glu Leu Thr Lys Leu Tyr Arg Arg Ser 
305                 310                 315                 320 


Leu His Arg Leu Gly Glu Leu Asp Arg Ala Cys Ala Arg Ile Arg Arg 
                325                 330                 335     


Arg Leu Gln Ala Ala His Asp Ile Ala Glu Pro Val Pro Asp Glu Ala 
            340                 345                 350         


Gly Ser Ala Val Leu Ile Glu Gly Ser Asn Ala Gly Met Arg His Ala 
        355                 360                 365             


Arg Arg Val Ala Arg Thr Gln Arg Arg Val Ala Arg Arg Thr Arg Ala 
    370                 375                 380                 


Gly His Ala His Ser Asn Arg Arg Lys Lys Ala Val Gln Ala Tyr Ala 
385                 390                 395                 400 


Arg Ala Lys Glu Arg Glu Arg Ser Ala Arg Gly Asp His Arg His Lys 
                405                 410                 415     


Val Ser Arg Ala Leu Val Arg Gln Phe Glu Glu Ile Ser Val Glu Ala 
            420                 425                 430         


Leu Asp Ile Lys Gln Leu Thr Val Ala Pro Glu His Asn Pro Asp Pro 
        435                 440                 445             


Gln Pro Asp Leu Pro Ala His Val Gln Arg Arg Arg Asn Arg Gly Glu 
    450                 455                 460                 


Leu Asp Ala Ala Trp Gly Ala Phe Phe Ala Ala Leu Asp Tyr Lys Ala 
465                 470                 475                 480 


Ala Asp Ala Gly Gly Arg Val Ala Arg Lys Pro Ala Pro His Thr Thr 
                485                 490                 495     


Gln Glu Cys Ala Arg Cys Gly Thr Leu Val Pro Lys Pro Ile Ser Leu 
            500                 505                 510         


Arg Val His Arg Cys Pro Ala Cys Gly Tyr Thr Ala Pro Arg Thr Val 
        515                 520                 525             


Asn Ser Ala Arg Asn Val Leu Gln Arg Pro Leu Glu Glu Pro Gly Arg 
    530                 535                 540                 


Ala Gly Pro Ser Gly Ala Asn Gly Arg Gly Val Pro His Ala Val Ala 
545                 550                 555                 560 


<210> 58
<211> 404
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Met Asn Cys Arg Tyr Arg Tyr Arg Ile Tyr Pro Thr Pro Gly Gln Arg 
1               5                   10                  15      


Gln Ser Leu Ala Arg Leu Phe Gly Cys Val Arg Val Val Trp Asn Asp 
            20                  25                  30          


Ala Leu Phe Leu Cys Arg Gln Ser Glu Lys Leu Pro Lys Asn Ser Glu 
        35                  40                  45              


Leu Gln Lys Leu Cys Ile Thr Gln Ala Lys Lys Thr Glu Ala Arg Gly 
    50                  55                  60                  


Trp Leu Gly Gln Val Ser Ala Ile Pro Leu Gln Gln Ser Val Ala Asp 
65                  70                  75                  80  


Leu Gly Val Ala Phe Lys Asn Phe Phe Gln Ser Arg Ser Gly Lys Arg 
                85                  90                  95      


Lys Gly Lys Lys Val Asn Pro Pro Arg Val Lys Arg Arg Asn Asn Arg 
            100                 105                 110         


Gln Gly Ala Arg Phe Thr Arg Gly Gly Phe Lys Val Lys Thr Ser Lys 
        115                 120                 125             


Val Tyr Leu Ala Arg Ile Gly Asp Ile Lys Ile Lys Trp Ser Arg Pro 
    130                 135                 140                 


Leu Pro Ser Glu Pro Ser Ser Val Thr Val Ile Lys Asp Cys Ala Gly 
145                 150                 155                 160 


Gln Tyr Phe Leu Ser Phe Val Val Glu Val Lys Pro Glu Ile Lys Pro 
                165                 170                 175     


Pro Lys Asn Pro Ser Ile Gly Ile Asp Leu Gly Leu Lys Thr Phe Ala 
            180                 185                 190         


Ser Cys Ser Asn Gly Glu Lys Ile Asp Ser Pro Asp Tyr Ser Arg Leu 
        195                 200                 205             


Tyr Arg Lys Leu Lys Arg Cys Gln Arg Arg Leu Ala Lys Arg Gln Arg 
    210                 215                 220                 


Gly Ser Lys Arg Arg Glu Arg Met Arg Val Lys Val Ala Lys Leu Asn 
225                 230                 235                 240 


Ala Gln Ile Arg Asp Lys Arg Lys Asp Phe Leu His Lys Leu Ser Thr 
                245                 250                 255     


Lys Val Val Asn Glu Asn Gln Val Ile Ala Leu Glu Asp Leu Asn Val 
            260                 265                 270         


Gly Gly Met Leu Lys Asn Arg Lys Leu Ser Arg Ala Ile Ser Gln Ala 
        275                 280                 285             


Gly Trp Tyr Glu Phe Arg Ser Leu Cys Glu Gly Lys Ala Glu Lys His 
    290                 295                 300                 


Asn Arg Asp Phe Arg Val Ile Ser Arg Trp Glu Pro Thr Ser Gln Val 
305                 310                 315                 320 


Cys Ser Glu Cys Gly Tyr Arg Trp Gly Lys Ile Asp Leu Ser Val Arg 
                325                 330                 335     


Ser Ile Val Cys Ile Asn Cys Gly Val Glu His Asp Arg Asp Asp Asn 
            340                 345                 350         


Ala Ser Val Asn Ile Glu Gln Ala Gly Leu Lys Val Gly Val Gly His 
        355                 360                 365             


Thr His Asp Ser Lys Arg Thr Gly Ser Ala Cys Lys Thr Ser Asn Gly 
    370                 375                 380                 


Ala Val Cys Val Glu Pro Ser Thr His Arg Glu Tyr Val Gln Leu Thr 
385                 390                 395                 400 


Leu Phe Asp Trp 
                


<210> 59
<211> 392
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Met Lys Ser Arg Trp Thr Phe Arg Cys Tyr Pro Thr Pro Glu Gln Glu 
1               5                   10                  15      


Gln His Leu Ala Arg Thr Phe Gly Cys Val Arg Phe Val Trp Asn Trp 
            20                  25                  30          


Ala Leu Arg Ala Arg Thr Asp Ala Phe Arg Ala Gly Glu Arg Ile Gly 
        35                  40                  45              


Tyr Pro Ala Thr Asp Lys Ala Leu Thr Leu Leu Lys Gln Gln Pro Glu 
    50                  55                  60                  


Thr Val Trp Leu Asn Glu Val Ser Ser Val Cys Leu Gln Gln Ala Leu 
65                  70                  75                  80  


Arg Asp Leu Gln Val Ala Phe Ser Asn Phe Phe Asp Lys Arg Ala Ala 
                85                  90                  95      


His Pro Ser Phe Lys Arg Lys Glu Ala Arg Gln Ser Ala Asn Tyr Thr 
            100                 105                 110         


Glu Arg Gly Phe Ser Phe Asp His Glu Arg Arg Ile Leu Lys Leu Ala 
        115                 120                 125             


Lys Ile Gly Ala Ile Lys Val Lys Trp Ser Arg Lys Ala Ile Pro His 
    130                 135                 140                 


Pro Ser Ser Ile Arg Leu Ile Arg Thr Ala Ser Gly Lys Tyr Phe Val 
145                 150                 155                 160 


Ser Leu Val Val Glu Thr Gln Pro Ala Pro Met Pro Glu Thr Gly Glu 
                165                 170                 175     


Ser Val Gly Val Asp Phe Gly Val Ala Arg Leu Ala Thr Leu Ser Asn 
            180                 185                 190         


Gly Glu Arg Ile Ser Asn Pro Lys His Gly Ala Lys Trp Gln Arg Arg 
        195                 200                 205             


Leu Ala Phe Tyr Gln Lys Arg Leu Ala Arg Ala Thr Lys Gly Ser Lys 
    210                 215                 220                 


Arg Arg Met Arg Ile Lys Arg His Val Ala Arg Ile His Glu Lys Ile 
225                 230                 235                 240 


Gly Asn Ser Arg Ser Asp Thr Leu His Lys Leu Ser Thr Asp Leu Val 
                245                 250                 255     


Thr Arg Phe Asp Leu Ile Cys Val Glu Asp Leu Asn Leu Arg Gly Met 
            260                 265                 270         


Val Lys Asn His Ser Leu Ala Arg Ser Leu His Asp Ala Ser Ile Gly 
        275                 280                 285             


Ser Ala Ile Arg Met Ile Glu Glu Lys Ala Glu Arg Tyr Gly Lys Asn 
    290                 295                 300                 


Val Val Lys Ile Asp Arg Trp Phe Pro Ser Ser Lys Thr Cys Ser Asp 
305                 310                 315                 320 


Cys Gly His Ile Val Glu Gln Leu Pro Leu Asn Val Arg Glu Trp Thr 
                325                 330                 335     


Cys Pro Glu Cys Gly Thr Thr His Asp Arg Asp Ala Asn Ala Ala Ala 
            340                 345                 350         


Asn Ile Leu Ala Val Gly Gln Thr Val Ser Ala His Gly Gly Thr Val 
        355                 360                 365             


Arg Arg Ser Arg Ala Lys Ala Ser Glu Arg Lys Ser Gln Arg Ser Ala 
    370                 375                 380                 


Asn Arg Gln Gly Val Asn Arg Ala 
385                 390         


<210> 60
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Lys Glu Pro Leu Asn Ile Gly Lys Thr Ala Lys Ala Val Phe Lys Glu 
1               5                   10                  15      


Ile Asp Pro Thr Ser Leu Asn Arg Ala Ala Asn Tyr Asp Ala Ser Ile 
            20                  25                  30          


Glu Leu Asn Cys Lys Glu Cys Lys Phe Lys Pro Phe Lys Asn Val Lys 
        35                  40                  45              


Arg Tyr Glu Phe Asn Phe Tyr Asn Asn Trp Tyr Arg Cys Asn Pro Asn 
    50                  55                  60                  


Ser Cys Leu Gln Ser Thr Tyr Lys Ala Gln Val Arg Lys Val Glu Ile 
65                  70                  75                  80  


Gly Tyr Glu Lys Leu Lys Asn Glu Ile Leu Thr Gln Met Gln Tyr Tyr 
                85                  90                  95      


Pro Trp Phe Gly Arg Leu Tyr Gln Asn Phe Phe His Asp Glu Arg Asp 
            100                 105                 110         


Lys Met Thr Ser Leu Asp Glu Ile Gln Val Ile Gly Val Gln Asn Lys 
        115                 120                 125             


Val Phe Phe Asn Thr Val Glu Lys Ala Trp Arg Glu Ile Ile Lys Lys 
    130                 135                 140                 


Arg Phe Lys Asp Asn Lys Glu Thr Met Glu Thr Ile Pro Glu Leu Lys 
145                 150                 155                 160 


His Ala Ala Gly His Gly Lys Arg Lys Leu Ser Asn Lys Ser Leu Leu 
                165                 170                 175     


Arg Arg Arg Phe Ala Phe Val Gln Lys Ser Phe Lys Phe Val Asp Asn 
            180                 185                 190         


Ser Asp Val Ser Tyr Arg Ser Phe Ser Asn Asn Ile Ala Cys Val Leu 
        195                 200                 205             


Pro Ser Arg Ile Gly Val Asp Leu Gly Gly Val Ile Ser Arg Asn Pro 
    210                 215                 220                 


Lys Arg Glu Tyr Ile Pro Gln Glu Ile Ser Phe Asn Ala Phe Trp Lys 
225                 230                 235                 240 


Gln His Glu Gly Leu Lys Lys Gly Arg Asn Ile Glu Ile Gln Ser Val 
                245                 250                 255     


Gln Tyr Lys Gly Glu Thr Val Lys Arg Ile Glu Ala Asp Thr Gly Glu 
            260                 265                 270         


Asp Lys Ala Trp Gly Lys Asn Arg Gln Arg Arg Phe Thr Ser Leu Ile 
        275                 280                 285             


Leu Lys Leu Val Pro Lys Gln Gly Gly Lys Lys Val Trp Lys Tyr Pro 
    290                 295                 300                 


Glu Lys Arg Asn Glu Gly Asn Tyr Glu Tyr Phe Pro Ile Pro Ile Glu 
305                 310                 315                 320 


Phe Ile Leu Asp Ser Gly Glu Thr Ser Ile Arg Phe Gly Gly Asp Glu 
                325                 330                 335     


Gly Glu Ala Gly Lys Gln Lys His Leu Val Ile Pro Phe Asn Asp Ser 
            340                 345                 350         


Lys Ala Thr Pro Leu Ala Ser Gln Gln Thr Leu Leu Glu Asn Ser Arg 
        355                 360                 365             


Phe Asn Ala Glu Val Lys Ser Cys Ile Gly Leu Ala Ile Tyr Ala Asn 
    370                 375                 380                 


Tyr Phe Tyr Gly Tyr Ala Arg Asn Tyr Val Ile Ser Ser Ile Tyr His 
385                 390                 395                 400 


Lys Asn Ser Lys Asn Gly Gln Ala Ile Thr Ala Ile Tyr Leu Glu Ser 
                405                 410                 415     


Ile Ala His Asn Tyr Val Lys Ala Ile Glu Arg Gln Leu Gln Asn Leu 
            420                 425                 430         


Leu Leu Asn Leu Arg Asp Phe Ser Phe Met Glu Ser His Lys Lys Glu 
        435                 440                 445             


Leu Lys Lys Tyr Phe Gly Gly Asp Leu Glu Gly Thr Gly Gly Ala Gln 
    450                 455                 460                 


Lys Arg Arg Glu Lys Glu Glu Lys Ile Glu Lys Glu Ile Glu Gln Ser 
465                 470                 475                 480 


Tyr Leu Pro Arg Leu Ile Arg Leu Ser Leu Thr Lys Met Val Thr Lys 
                485                 490                 495     


Gln Val Glu Met 
            500 


<210> 61

<400> 61
000


<210> 62
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Glu Leu Ile Val Asn Glu Asn Lys Asp Pro Leu Asn Ile Gly Lys Thr 
1               5                   10                  15      


Ala Lys Ala Val Phe Lys Glu Ile Asp Pro Thr Ser Ile Asn Arg Ala 
            20                  25                  30          


Ala Asn Tyr Asp Ala Ser Ile Glu Leu Ala Cys Lys Glu Cys Lys Phe 
        35                  40                  45              


Lys Pro Phe Asn Asn Thr Lys Arg His Asp Phe Ser Phe Tyr Ser Asn 
    50                  55                  60                  


Trp His Arg Cys Ser Pro Asn Ser Cys Leu Gln Ser Thr Tyr Arg Ala 
65                  70                  75                  80  


Lys Ile Arg Lys Thr Glu Ile Gly Tyr Glu Lys Leu Lys Asn Glu Ile 
                85                  90                  95      


Leu Asn Gln Met Gln Tyr Tyr Pro Trp Phe Gly Arg Leu Tyr Gln Asn 
            100                 105                 110         


Phe Phe Asn Asp Gln Arg Asp Lys Met Thr Ser Leu Asp Glu Ile Gln 
        115                 120                 125             


Val Thr Gly Val Gln Asn Lys Ile Phe Phe Asn Thr Val Glu Lys Ala 
    130                 135                 140                 


Trp Arg Glu Ile Ile Lys Lys Arg Phe Arg Asp Asn Lys Glu Thr Met 
145                 150                 155                 160 


Arg Thr Ile Pro Asp Leu Lys Asn Lys Ser Gly His Gly Ser Arg Lys 
                165                 170                 175     


Leu Ser Asn Lys Ser Leu Leu Arg Arg Arg Phe Ala Phe Ala Gln Lys 
            180                 185                 190         


Ser Phe Lys Leu Val Asp Asn Ser Asp Val Ser Tyr Arg Ala Phe Ser 
        195                 200                 205             


Asn Asn Val Ala Cys Val Leu Pro Ser Lys Ile Gly Val Asp Ile Gly 
    210                 215                 220                 


Gly Ile Ile Asn Lys Asp Leu Lys Arg Glu Tyr Ile Pro Gln Glu Ile 
225                 230                 235                 240 


Thr Phe Asn Val Phe Trp Lys Gln His Asp Gly Leu Lys Lys Gly Arg 
                245                 250                 255     


Asn Ile Glu Ile His Ser Val Gln Tyr Lys Gly Glu Ile Val Lys Arg 
            260                 265                 270         


Ile Glu Ala Asp Thr Gly Glu Asp Lys Ala Trp Gly Lys Asn Arg Gln 
        275                 280                 285             


Arg Arg Phe Thr Ser Leu Ile Leu Lys Ile Thr Pro Lys Gln Gly Gly 
    290                 295                 300                 


Lys Lys Ile Trp Lys Phe Pro Glu Lys Lys Asn Ala Ser Asp Tyr Glu 
305                 310                 315                 320 


Tyr Phe Pro Ile Pro Ile Glu Phe Ile Leu Asp Asn Gly Asp Ala Ser 
                325                 330                 335     


Ile Lys Phe Gly Gly Glu Glu Gly Glu Val Gly Lys Gln Lys His Leu 
            340                 345                 350         


Leu Ile Pro Phe Asn Asp Ser Lys Ala Thr Pro Leu Ser Ser Lys Gln 
        355                 360                 365             


Met Leu Leu Glu Thr Ser Arg Phe Asn Ala Glu Val Lys Ser Thr Ile 
    370                 375                 380                 


Gly Leu Ala Leu Tyr Ala Asn Tyr Phe Val Ser Tyr Ala Arg Asn Tyr 
385                 390                 395                 400 


Val Ile Lys Ser Thr Tyr His Lys Asn Ser Lys Lys Gly Gln Ile Val 
                405                 410                 415     


Thr Glu Ile Tyr Leu Glu Ser Ile Ser Gln Asn Phe Val Arg Ala Ile 
            420                 425                 430         


Gln Arg Gln Leu Gln Ser Leu Met Leu Asn Leu Lys Asp Trp Gly Phe 
        435                 440                 445             


Met Gln Thr His Lys Lys Glu Leu Lys Lys Tyr Phe Gly Ser Asp Leu 
    450                 455                 460                 


Glu Gly Ser Lys Gly Gly Gln Lys Arg Arg Glu Lys Glu Glu Lys Ile 
465                 470                 475                 480 


Glu Lys Glu Ile Glu Ala Ser Tyr Leu Pro Arg Leu Ile Arg Leu Ser 
                485                 490                 495     


Leu Thr Lys Ser Val Thr Lys Ala Glu Glu Met 
            500                 505         


<210> 63
<211> 529
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Pro Glu Glu Lys Thr Ser Lys Leu Lys Pro Asn Ser Ile Asn Leu Ala 
1               5                   10                  15      


Ala Asn Tyr Asp Ala Asn Glu Lys Phe Asn Cys Lys Glu Cys Lys Phe 
            20                  25                  30          


His Pro Phe Lys Asn Lys Lys Arg Tyr Glu Phe Asn Phe Tyr Asn Asn 
        35                  40                  45              


Leu His Gly Cys Lys Ser Cys Thr Lys Ser Thr Asn Asn Pro Ala Val 
    50                  55                  60                  


Lys Arg Ile Glu Ile Gly Tyr Gln Lys Leu Lys Phe Glu Ile Lys Asn 
65                  70                  75                  80  


Gln Met Glu Ala Tyr Pro Trp Phe Gly Arg Leu Arg Ile Asn Phe Tyr 
                85                  90                  95      


Ser Asp Glu Lys Arg Lys Met Ser Glu Leu Asn Glu Met Gln Val Thr 
            100                 105                 110         


Gly Val Lys Asn Lys Ile Phe Phe Asp Ala Ile Glu Cys Ala Trp Arg 
        115                 120                 125             


Glu Ile Leu Lys Lys Arg Phe Arg Glu Ser Lys Glu Thr Leu Ile Thr 
    130                 135                 140                 


Ile Pro Lys Leu Lys Asn Lys Ala Gly His Gly Ala Arg Lys His Arg 
145                 150                 155                 160 


Asn Lys Lys Leu Leu Ile Arg Arg Arg Ala Phe Met Lys Lys Asn Phe 
                165                 170                 175     


His Phe Leu Asp Asn Asp Ser Ile Ser Tyr Arg Ser Phe Ala Asn Asn 
            180                 185                 190         


Ile Ala Cys Val Leu Pro Ser Lys Val Gly Val Asp Ile Gly Gly Ile 
        195                 200                 205             


Ile Ser Pro Asp Val Gly Lys Asp Ile Lys Pro Val Asp Ile Ser Leu 
    210                 215                 220                 


Asn Leu Met Trp Ala Ser Lys Glu Gly Ile Lys Ser Gly Arg Lys Val 
225                 230                 235                 240 


Glu Ile Tyr Ser Thr Gln Tyr Asp Gly Asn Met Val Lys Lys Ile Glu 
                245                 250                 255     


Ala Glu Thr Gly Glu Asp Lys Ser Trp Gly Lys Asn Arg Lys Arg Arg 
            260                 265                 270         


Gln Thr Ser Leu Leu Leu Ser Ile Pro Lys Pro Ser Lys Gln Val Gln 
        275                 280                 285             


Glu Phe Asp Phe Lys Glu Trp Pro Arg Tyr Lys Asp Ile Glu Lys Lys 
    290                 295                 300                 


Val Gln Trp Arg Gly Phe Pro Ile Lys Ile Ile Phe Asp Ser Asn His 
305                 310                 315                 320 


Asn Ser Ile Glu Phe Gly Thr Tyr Gln Gly Gly Lys Gln Lys Val Leu 
                325                 330                 335     


Pro Ile Pro Phe Asn Asp Ser Lys Thr Thr Pro Leu Gly Ser Lys Met 
            340                 345                 350         


Asn Lys Leu Glu Lys Leu Arg Phe Asn Ser Lys Ile Lys Ser Arg Leu 
        355                 360                 365             


Gly Ser Ala Ile Ala Ala Asn Lys Phe Leu Glu Ala Ala Arg Thr Tyr 
    370                 375                 380                 


Cys Val Asp Ser Leu Tyr His Glu Val Ser Ser Ala Asn Ala Ile Gly 
385                 390                 395                 400 


Lys Gly Lys Ile Phe Ile Glu Tyr Tyr Leu Glu Ile Leu Ser Gln Asn 
                405                 410                 415     


Tyr Ile Glu Ala Ala Gln Lys Gln Leu Gln Arg Phe Ile Glu Ser Ile 
            420                 425                 430         


Glu Gln Trp Phe Val Ala Asp Pro Phe Gln Gly Arg Leu Lys Gln Tyr 
        435                 440                 445             


Phe Lys Asp Asp Leu Lys Arg Ala Lys Cys Phe Leu Cys Ala Asn Arg 
    450                 455                 460                 


Glu Val Gln Thr Thr Cys Tyr Ala Ala Val Lys Leu His Lys Ser Cys 
465                 470                 475                 480 


Ala Glu Lys Val Lys Asp Lys Asn Lys Glu Leu Ala Ile Lys Glu Arg 
                485                 490                 495     


Asn Asn Lys Glu Asp Ala Val Ile Lys Glu Val Glu Ala Ser Asn Tyr 
            500                 505                 510         


Pro Arg Val Ile Arg Leu Lys Leu Thr Lys Thr Ile Thr Asn Lys Ala 
        515                 520                 525             


Met 
    


<210> 64
<211> 726
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Ser Glu Ser Glu Asn Lys Ile Ile Glu Gln Tyr Tyr Ala Phe Leu Tyr 
1               5                   10                  15      


Ser Phe Arg Asp Lys Tyr Glu Lys Pro Glu Phe Lys Asn Arg Gly Asp 
            20                  25                  30          


Ile Lys Arg Lys Leu Gln Asn Lys Trp Glu Asp Phe Leu Lys Glu Gln 
        35                  40                  45              


Asn Leu Lys Asn Asp Lys Lys Leu Ser Asn Tyr Ile Phe Ser Asn Arg 
    50                  55                  60                  


Asn Phe Arg Arg Ser Tyr Asp Arg Glu Glu Glu Asn Glu Glu Gly Ile 
65                  70                  75                  80  


Asp Glu Lys Lys Ser Lys Pro Lys Arg Ile Asn Cys Phe Glu Lys Glu 
                85                  90                  95      


Lys Asn Leu Lys Asp Gln Tyr Asp Lys Asp Ala Ile Asn Ala Ser Ala 
            100                 105                 110         


Asn Lys Asp Gly Ala Gln Lys Trp Gly Cys Phe Glu Cys Ile Phe Phe 
        115                 120                 125             


Pro Met Tyr Lys Ile Glu Ser Gly Asp Pro Asn Lys Arg Ile Ile Ile 
    130                 135                 140                 


Asn Lys Thr Arg Phe Lys Leu Phe Asp Phe Tyr Leu Asn Leu Lys Gly 
145                 150                 155                 160 


Cys Lys Ser Cys Leu Arg Ser Thr Tyr His Pro Tyr Arg Ser Asn Val 
                165                 170                 175     


Tyr Ile Glu Ser Asn Tyr Asp Lys Leu Lys Arg Glu Ile Gly Asn Phe 
            180                 185                 190         


Leu Gln Gln Lys Asn Ile Phe Gln Arg Met Arg Lys Ala Lys Val Ser 
        195                 200                 205             


Glu Gly Lys Tyr Leu Thr Asn Leu Asp Glu Tyr Arg Leu Ser Cys Val 
    210                 215                 220                 


Ala Met His Phe Lys Asn Arg Trp Leu Phe Phe Asp Ser Ile Gln Lys 
225                 230                 235                 240 


Val Leu Arg Glu Thr Ile Lys Gln Arg Leu Lys Gln Met Arg Glu Ser 
                245                 250                 255     


Tyr Asp Glu Gln Ala Lys Thr Lys Arg Ser Lys Gly His Gly Arg Ala 
            260                 265                 270         


Lys Tyr Glu Asp Gln Val Arg Met Ile Arg Arg Arg Ala Tyr Ser Ala 
        275                 280                 285             


Gln Ala His Lys Leu Leu Asp Asn Gly Tyr Ile Thr Leu Phe Asp Tyr 
    290                 295                 300                 


Asp Asp Lys Glu Ile Asn Lys Val Cys Leu Thr Ala Ile Asn Gln Glu 
305                 310                 315                 320 


Gly Phe Asp Ile Gly Gly Tyr Leu Asn Ser Asp Ile Asp Asn Val Met 
                325                 330                 335     


Pro Pro Ile Glu Ile Ser Phe His Leu Lys Trp Lys Tyr Asn Glu Pro 
            340                 345                 350         


Ile Leu Asn Ile Glu Ser Pro Phe Ser Lys Ala Lys Ile Ser Asp Tyr 
        355                 360                 365             


Leu Arg Lys Ile Arg Glu Asp Leu Asn Leu Glu Arg Gly Lys Glu Gly 
    370                 375                 380                 


Lys Ala Arg Ser Lys Lys Asn Val Arg Arg Lys Val Leu Ala Ser Lys 
385                 390                 395                 400 


Gly Glu Asp Gly Tyr Lys Lys Ile Phe Thr Asp Phe Phe Ser Lys Trp 
                405                 410                 415     


Lys Glu Glu Leu Glu Gly Asn Ala Met Glu Arg Val Leu Ser Gln Ser 
            420                 425                 430         


Ser Gly Asp Ile Gln Trp Ser Lys Lys Lys Arg Ile His Tyr Thr Thr 
        435                 440                 445             


Leu Val Leu Asn Ile Asn Leu Leu Asp Lys Lys Gly Val Gly Asn Leu 
    450                 455                 460                 


Lys Tyr Tyr Glu Ile Ala Glu Lys Thr Lys Ile Leu Ser Phe Asp Lys 
465                 470                 475                 480 


Asn Glu Asn Lys Phe Trp Pro Ile Thr Ile Gln Val Leu Leu Asp Gly 
                485                 490                 495     


Tyr Glu Ile Gly Thr Glu Tyr Asp Glu Ile Lys Gln Leu Asn Glu Lys 
            500                 505                 510         


Thr Ser Lys Gln Phe Thr Ile Tyr Asp Pro Asn Thr Lys Ile Ile Lys 
        515                 520                 525             


Ile Pro Phe Thr Asp Ser Lys Ala Val Pro Leu Gly Met Leu Gly Ile 
    530                 535                 540                 


Asn Ile Ala Thr Leu Lys Thr Val Lys Lys Thr Glu Arg Asp Ile Lys 
545                 550                 555                 560 


Val Ser Lys Ile Phe Lys Gly Gly Leu Asn Ser Lys Ile Val Ser Lys 
                565                 570                 575     


Ile Gly Lys Gly Ile Tyr Ala Gly Tyr Phe Pro Thr Val Asp Lys Glu 
            580                 585                 590         


Ile Leu Glu Glu Val Glu Glu Asp Thr Leu Asp Asn Glu Phe Ser Ser 
        595                 600                 605             


Lys Ser Gln Arg Asn Ile Phe Leu Lys Ser Ile Ile Lys Asn Tyr Asp 
    610                 615                 620                 


Lys Met Leu Lys Glu Gln Leu Phe Asp Phe Tyr Ser Phe Leu Val Arg 
625                 630                 635                 640 


Asn Asp Leu Gly Val Arg Phe Leu Thr Asp Arg Glu Leu Gln Asn Ile 
                645                 650                 655     


Glu Asp Glu Ser Phe Asn Leu Glu Lys Arg Phe Phe Glu Thr Asp Arg 
            660                 665                 670         


Asp Arg Ile Ala Arg Trp Phe Asp Asn Thr Asn Thr Asp Asp Gly Lys 
        675                 680                 685             


Glu Lys Phe Lys Lys Leu Ala Asn Glu Ile Val Asp Ser Tyr Lys Pro 
    690                 695                 700                 


Arg Leu Ile Arg Leu Pro Val Val Arg Val Ile Lys Arg Ile Gln Pro 
705                 710                 715                 720 


Val Lys Gln Arg Glu Met 
                725     


<210> 65
<211> 517
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Lys Tyr Ser Thr Arg Asp Phe Ser Glu Leu Asn Glu Ile Gln Val Thr 
1               5                   10                  15      


Ala Cys Lys Gln Asp Glu Phe Phe Lys Val Ile Gln Asn Ala Trp Arg 
            20                  25                  30          


Glu Ile Ile Lys Lys Arg Phe Leu Glu Asn Arg Glu Asn Phe Ile Glu 
        35                  40                  45              


Lys Lys Ile Phe Lys Asn Lys Lys Gly Arg Gly Lys Arg Gln Glu Ser 
    50                  55                  60                  


Asp Lys Thr Ile Gln Arg Asn Arg Ala Ser Val Met Lys Asn Phe Gln 
65                  70                  75                  80  


Leu Ile Glu Asn Glu Lys Ile Ile Leu Arg Ala Pro Ser Gly His Val 
                85                  90                  95      


Ala Cys Val Phe Pro Val Lys Val Gly Leu Asp Ile Gly Gly Phe Lys 
            100                 105                 110         


Thr Asp Asp Leu Glu Lys Asn Ile Phe Pro Pro Arg Thr Ile Thr Ile 
        115                 120                 125             


Asn Val Phe Trp Lys Asn Arg Asp Arg Gln Arg Lys Gly Arg Lys Leu 
    130                 135                 140                 


Glu Val Trp Gly Ile Lys Ala Arg Thr Lys Leu Ile Glu Lys Val His 
145                 150                 155                 160 


Lys Trp Asp Lys Leu Glu Glu Val Lys Lys Lys Arg Leu Lys Ser Leu 
                165                 170                 175     


Glu Gln Lys Gln Glu Lys Ser Leu Asp Asn Trp Ser Glu Val Asn Asn 
            180                 185                 190         


Asp Ser Phe Tyr Lys Val Gln Ile Asp Glu Leu Gln Glu Lys Ile Asp 
        195                 200                 205             


Lys Ser Leu Lys Gly Arg Thr Met Asn Lys Ile Leu Asp Asn Lys Ala 
    210                 215                 220                 


Lys Glu Ser Lys Glu Ala Glu Gly Leu Tyr Ile Glu Trp Glu Lys Asp 
225                 230                 235                 240 


Phe Glu Gly Glu Met Leu Arg Arg Ile Glu Ala Ser Thr Gly Gly Glu 
                245                 250                 255     


Glu Lys Trp Gly Lys Arg Arg Gln Arg Arg His Thr Ser Leu Leu Leu 
            260                 265                 270         


Asp Ile Lys Asn Asn Ser Arg Gly Ser Lys Glu Ile Ile Asn Phe Tyr 
        275                 280                 285             


Ser Tyr Ala Lys Gln Gly Lys Lys Glu Lys Lys Ile Glu Phe Phe Pro 
    290                 295                 300                 


Phe Pro Leu Thr Ile Thr Leu Asp Ala Glu Glu Glu Ser Pro Leu Asn 
305                 310                 315                 320 


Ile Lys Ser Ile Pro Ile Glu Asp Lys Asn Ala Thr Ser Lys Tyr Phe 
                325                 330                 335     


Ser Ile Pro Phe Thr Glu Thr Arg Ala Thr Pro Leu Ser Ile Leu Gly 
            340                 345                 350         


Asp Arg Val Gln Lys Phe Lys Thr Lys Asn Ile Ser Gly Ala Ile Lys 
        355                 360                 365             


Arg Asn Leu Gly Ser Ser Ile Ser Ser Cys Lys Ile Val Gln Asn Ala 
    370                 375                 380                 


Glu Thr Ser Ala Lys Ser Ile Leu Ser Leu Pro Asn Val Lys Glu Asp 
385                 390                 395                 400 


Asn Asn Met Glu Ile Phe Ile Asn Thr Met Ser Lys Asn Tyr Phe Arg 
                405                 410                 415     


Ala Met Met Lys Gln Met Glu Ser Phe Ile Phe Glu Met Glu Pro Lys 
            420                 425                 430         


Thr Leu Ile Asp Pro Tyr Lys Glu Lys Ala Ile Lys Trp Phe Glu Val 
        435                 440                 445             


Ala Ala Ser Ser Arg Ala Lys Arg Lys Leu Lys Lys Leu Ser Lys Ala 
    450                 455                 460                 


Asp Ile Lys Lys Ser Glu Leu Leu Leu Ser Asn Thr Glu Glu Phe Glu 
465                 470                 475                 480 


Lys Glu Lys Gln Glu Lys Leu Glu Ala Leu Glu Lys Glu Ile Glu Glu 
                485                 490                 495     


Phe Tyr Leu Pro Arg Ile Val Arg Leu Gln Leu Thr Lys Thr Ile Leu 
            500                 505                 510         


Glu Thr Pro Val Met 
        515         


<210> 66
<211> 481
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Lys Lys Leu Gln Leu Leu Gly His Lys Ile Leu Leu Lys Glu Tyr Asp 
1               5                   10                  15      


Pro Asn Ala Val Asn Ala Ala Ala Asn Phe Glu Thr Ser Thr Ala Glu 
            20                  25                  30          


Leu Cys Gly Gln Cys Lys Met Lys Pro Phe Lys Asn Lys Arg Arg Phe 
        35                  40                  45              


Gln Tyr Thr Phe Gly Lys Asn Tyr His Gly Cys Leu Ser Cys Ile Gln 
    50                  55                  60                  


Asn Val Tyr Tyr Ala Lys Lys Arg Ile Val Gln Ile Ala Lys Glu Glu 
65                  70                  75                  80  


Leu Lys His Gln Leu Thr Asp Ser Ile Ala Ser Ile Pro Tyr Lys Tyr 
                85                  90                  95      


Thr Ser Leu Phe Ser Asn Thr Asn Ser Ile Asp Glu Leu Tyr Ile Leu 
            100                 105                 110         


Lys Gln Glu Arg Ala Ala Phe Phe Ser Asn Thr Asn Ser Ile Asp Glu 
        115                 120                 125             


Leu Tyr Ile Thr Gly Ile Glu Asn Asn Ile Ala Phe Lys Val Ile Ser 
    130                 135                 140                 


Ala Ile Trp Asp Glu Ile Ile Lys Lys Arg Arg Gln Arg Tyr Ala Glu 
145                 150                 155                 160 


Ser Leu Thr Asp Thr Gly Thr Val Lys Ala Asn Arg Gly His Gly Gly 
                165                 170                 175     


Thr Ala Tyr Lys Ser Asn Thr Arg Gln Glu Lys Ile Arg Ala Leu Gln 
            180                 185                 190         


Lys Gln Thr Leu His Met Val Thr Asn Pro Tyr Ile Ser Leu Ala Arg 
        195                 200                 205             


Tyr Lys Asn Asn Tyr Ile Val Ala Thr Leu Pro Arg Thr Ile Gly Met 
    210                 215                 220                 


His Ile Gly Ala Ile Lys Asp Arg Asp Pro Gln Lys Lys Leu Ser Asp 
225                 230                 235                 240 


Tyr Ala Ile Asn Phe Asn Val Phe Trp Ser Asp Asp Arg Gln Leu Ile 
                245                 250                 255     


Glu Leu Ser Thr Val Gln Tyr Thr Gly Asp Met Val Arg Lys Ile Glu 
            260                 265                 270         


Ala Glu Thr Gly Glu Asn Asn Lys Trp Gly Glu Asn Met Lys Arg Thr 
        275                 280                 285             


Lys Thr Ser Leu Leu Leu Glu Ile Leu Thr Lys Lys Thr Thr Asp Glu 
    290                 295                 300                 


Leu Thr Phe Lys Asp Trp Ala Phe Ser Thr Lys Lys Glu Ile Asp Ser 
305                 310                 315                 320 


Val Thr Lys Lys Thr Tyr Gln Gly Phe Pro Ile Gly Ile Ile Phe Glu 
                325                 330                 335     


Gly Asn Glu Ser Ser Val Lys Phe Gly Ser Gln Asn Tyr Phe Pro Leu 
            340                 345                 350         


Pro Phe Asp Ala Lys Ile Thr Pro Pro Thr Ala Glu Gly Phe Arg Leu 
        355                 360                 365             


Asp Trp Leu Arg Lys Gly Ser Phe Ser Ser Gln Met Lys Thr Ser Tyr 
    370                 375                 380                 


Gly Leu Ala Ile Tyr Ser Asn Lys Val Thr Asn Ala Ile Pro Ala Tyr 
385                 390                 395                 400 


Val Ile Lys Asn Met Phe Tyr Lys Ile Ala Arg Ala Glu Asn Gly Lys 
                405                 410                 415     


Gln Ile Lys Ala Lys Phe Leu Lys Lys Tyr Leu Asp Ile Ala Gly Asn 
            420                 425                 430         


Asn Tyr Val Pro Phe Ile Ile Met Gln His Tyr Arg Val Leu Asp Thr 
        435                 440                 445             


Phe Glu Glu Met Pro Ile Ser Gln Pro Lys Val Ile Arg Leu Ser Leu 
    450                 455                 460                 


Thr Lys Thr Gln His Ile Ile Ile Lys Lys Asp Lys Thr Asp Ser Lys 
465                 470                 475                 480 


Met 
    


<210> 67
<211> 534
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Asn Thr Ser Asn Leu Ile Asn Leu Gly Lys Lys Ala Ile Asn Ile Ser 
1               5                   10                  15      


Ala Asn Tyr Asp Ala Asn Leu Glu Val Gly Cys Lys Asn Cys Lys Phe 
            20                  25                  30          


Leu Ser Ser Asn Gly Asn Phe Pro Arg Gln Thr Asn Val Lys Glu Gly 
        35                  40                  45              


Cys His Ser Cys Glu Lys Ser Thr Tyr Glu Pro Ser Ile Tyr Leu Val 
    50                  55                  60                  


Lys Ile Gly Glu Arg Lys Ala Lys Tyr Asp Val Leu Asp Ser Leu Lys 
65                  70                  75                  80  


Lys Phe Thr Phe Gln Ser Leu Lys Tyr Gln Ser Lys Lys Ser Met Lys 
                85                  90                  95      


Ser Arg Asn Lys Lys Pro Lys Glu Leu Lys Glu Phe Val Ile Phe Ala 
            100                 105                 110         


Asn Lys Asn Lys Ala Phe Asp Val Ile Gln Lys Ser Tyr Asn His Leu 
        115                 120                 125             


Ile Leu Gln Ile Lys Lys Glu Ile Asn Arg Met Asn Ser Lys Lys Arg 
    130                 135                 140                 


Lys Lys Asn His Lys Arg Arg Leu Phe Arg Asp Arg Glu Lys Gln Leu 
145                 150                 155                 160 


Asn Lys Leu Arg Leu Ile Glu Ser Ser Asn Leu Phe Leu Pro Arg Glu 
                165                 170                 175     


Asn Lys Gly Asn Asn His Val Phe Thr Tyr Val Ala Ile His Ser Val 
            180                 185                 190         


Gly Arg Asp Ile Gly Val Ile Gly Ser Tyr Asp Glu Lys Leu Asn Phe 
        195                 200                 205             


Glu Thr Glu Leu Thr Tyr Gln Leu Tyr Phe Asn Asp Asp Lys Arg Leu 
    210                 215                 220                 


Leu Tyr Ala Tyr Lys Pro Lys Gln Asn Lys Ile Ile Lys Ile Lys Glu 
225                 230                 235                 240 


Lys Leu Trp Asn Leu Arg Lys Glu Lys Glu Pro Leu Asp Leu Glu Tyr 
                245                 250                 255     


Glu Lys Pro Leu Asn Lys Ser Ile Thr Phe Ser Ile Lys Asn Asp Asn 
            260                 265                 270         


Leu Phe Lys Val Ser Lys Asp Leu Met Leu Arg Arg Ala Lys Phe Asn 
        275                 280                 285             


Ile Gln Gly Lys Glu Lys Leu Ser Lys Glu Glu Arg Lys Ile Asn Arg 
    290                 295                 300                 


Asp Leu Ile Lys Ile Lys Gly Leu Val Asn Ser Met Ser Tyr Gly Arg 
305                 310                 315                 320 


Phe Asp Glu Leu Lys Lys Glu Lys Asn Ile Trp Ser Pro His Ile Tyr 
                325                 330                 335     


Arg Glu Val Arg Gln Lys Glu Ile Lys Pro Cys Leu Ile Lys Asn Gly 
            340                 345                 350         


Asp Arg Ile Glu Ile Phe Glu Gln Leu Lys Lys Lys Met Glu Arg Leu 
        355                 360                 365             


Arg Arg Phe Arg Glu Lys Arg Gln Lys Lys Ile Ser Lys Asp Leu Ile 
    370                 375                 380                 


Phe Ala Glu Arg Ile Ala Tyr Asn Phe His Thr Lys Ser Ile Lys Asn 
385                 390                 395                 400 


Thr Ser Asn Lys Ile Asn Ile Asp Gln Glu Ala Lys Arg Gly Lys Ala 
                405                 410                 415     


Ser Tyr Met Arg Lys Arg Ile Gly Tyr Glu Thr Phe Lys Asn Lys Tyr 
            420                 425                 430         


Cys Glu Gln Cys Leu Ser Lys Gly Asn Val Tyr Arg Asn Val Gln Lys 
        435                 440                 445             


Gly Cys Ser Cys Phe Glu Asn Pro Phe Asp Trp Ile Lys Lys Gly Asp 
    450                 455                 460                 


Glu Asn Leu Leu Pro Lys Lys Asn Glu Asp Leu Arg Val Lys Gly Ala 
465                 470                 475                 480 


Phe Arg Asp Glu Ala Leu Glu Lys Gln Ile Val Lys Ile Ala Phe Asn 
                485                 490                 495     


Ile Ala Lys Gly Tyr Glu Asp Phe Tyr Asp Asn Leu Gly Glu Ser Thr 
            500                 505                 510         


Glu Lys Asp Leu Lys Leu Lys Phe Lys Val Gly Thr Thr Ile Asn Glu 
        515                 520                 525             


Gln Glu Ser Leu Lys Leu 
    530                 


<210> 68
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Thr Ser Asn Pro Ile Lys Leu Gly Lys Lys Ala Ile Asn Ile Ser Ala 
1               5                   10                  15      


Asn Tyr Asp Ser Asn Leu Gln Ile Gly Cys Lys Asn Cys Lys Phe Leu 
            20                  25                  30          


Ser Tyr Asn Gly Asn Phe Pro Arg Gln Thr Asn Val Lys Glu Gly Cys 
        35                  40                  45              


His Ser Cys Glu Lys Ser Thr Tyr Glu Pro Pro Val Tyr Thr Val Arg 
    50                  55                  60                  


Ile Gly Glu Arg Arg Ser Lys Tyr Asp Val Leu Asp Ser Leu Lys Lys 
65                  70                  75                  80  


Phe Ile Phe Leu Ser Leu Lys Tyr Arg Gln Ser Lys Lys Met Lys Thr 
                85                  90                  95      


Arg Ser Lys Gly Ile Arg Gly Leu Glu Glu Phe Val Ile Ser Ala Asn 
            100                 105                 110         


Leu Lys Lys Ala Met Asp Val Ile Gln Lys Ser Tyr Arg His Leu Ile 
        115                 120                 125             


Leu Asn Ile Lys Asn Glu Ile Val Arg Met Asn Gly Lys Lys Arg Asn 
    130                 135                 140                 


Lys Asn His Lys Arg Leu Leu Phe Arg Asp Arg Glu Lys Gln Leu Asn 
145                 150                 155                 160 


Lys Leu Arg Leu Ile Glu Gly Ser Ser Phe Phe Lys Pro Pro Thr Val 
                165                 170                 175     


Lys Gly Asp Asn Ser Ile Phe Thr Cys Val Ala Ile His Asn Ile Gly 
            180                 185                 190         


Arg Asp Ile Gly Ile Ala Gly Asp Tyr Phe Asp Lys Leu Glu Pro Lys 
        195                 200                 205             


Ile Glu Leu Thr Tyr Gln Leu Tyr Tyr Glu Tyr Asn Pro Lys Lys Glu 
    210                 215                 220                 


Ser Glu Ile Asn Lys Arg Leu Leu Tyr Ala Tyr Lys Pro Lys Gln Asn 
225                 230                 235                 240 


Lys Ile Ile Glu Ile Lys Glu Lys Leu Trp Asn Leu Arg Lys Glu Lys 
                245                 250                 255     


Ser Pro Leu Asp Leu Glu Tyr Glu Lys Pro Leu Thr Lys Ser Ile Thr 
            260                 265                 270         


Phe Leu Val Lys Arg Asp Gly Val Phe Arg Ile Ser Lys Asp Leu Met 
        275                 280                 285             


Leu Arg Lys Ala Lys Phe Ile Ile Gln Gly Lys Glu Lys Leu Ser Lys 
    290                 295                 300                 


Glu Glu Arg Lys Ile Asn Arg Asp Leu Ile Lys Ile Lys Ser Asn Ile 
305                 310                 315                 320 


Ile Ser Leu Thr Tyr Gly Arg Phe Asp Glu Leu Lys Lys Asp Lys Thr 
                325                 330                 335     


Ile Trp Ser Pro His Ile Phe Arg Asp Val Lys Gln Gly Lys Ile Thr 
            340                 345                 350         


Pro Cys Ile Glu Arg Lys Gly Asp Arg Met Asp Ile Phe Gln Gln Leu 
        355                 360                 365             


Arg Lys Lys Ser Glu Arg Leu Arg Glu Asn Arg Lys Lys Arg Gln Lys 
    370                 375                 380                 


Lys Ile Ser Lys Asp Leu Ile Phe Ala Glu Arg Ile Ala Tyr Asn Phe 
385                 390                 395                 400 


His Thr Lys Ser Ile Lys Asn Thr Ser Asn Leu Ile Asn Ile Lys His 
                405                 410                 415     


Glu Ala Lys Arg Gly Lys Ala Ser Tyr Met Arg Lys Arg Ile Gly Asn 
            420                 425                 430         


Glu Thr Phe Arg Ile Lys Tyr Cys Glu Gln Cys Phe Pro Lys Asn Asn 
        435                 440                 445             


Val Tyr Lys Asn Val Gln Lys Gly Cys Ser Cys Phe Glu Asp Pro Phe 
    450                 455                 460                 


Glu Tyr Ile Lys Lys Gly Asn Glu Asp Leu Ile Pro Asn Lys Asn Gln 
465                 470                 475                 480 


Asp Leu Lys Ala Lys Gly Ala Phe Arg Asp Asp Ala Leu Glu Lys Gln 
                485                 490                 495     


Ile Ile Lys Val Ala Phe Asn Ile Ala Lys Gly Tyr Glu Asp Phe Tyr 
            500                 505                 510         


Glu Asn Leu Lys Lys Thr Thr Glu Lys Asp Ile Arg Leu Lys Phe Lys 
        515                 520                 525             


Val Gly Thr Ile Ile Ser Glu Glu Met 
    530                 535         


<210> 69
<211> 541
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Asn Asn Ser Ile Asn Leu Ser Lys Lys Ala Ile Asn Ile Ser Ala Asn 
1               5                   10                  15      


Tyr Asp Ala Asn Leu Gln Val Arg Cys Lys Asn Cys Lys Phe Leu Ser 
            20                  25                  30          


Ser Asn Gly Asn Phe Pro Arg Gln Thr Asp Val Lys Glu Gly Cys His 
        35                  40                  45              


Ser Cys Glu Lys Ser Thr Tyr Glu Pro Pro Val Tyr Asp Val Lys Ile 
    50                  55                  60                  


Gly Glu Ile Lys Ala Lys Tyr Glu Val Leu Asp Ser Leu Lys Lys Phe 
65                  70                  75                  80  


Thr Phe Gln Ser Leu Lys Tyr Gln Leu Ser Lys Ser Met Lys Phe Arg 
                85                  90                  95      


Ser Lys Lys Ile Lys Glu Leu Lys Glu Phe Val Ile Phe Ala Lys Glu 
            100                 105                 110         


Ser Lys Ala Leu Asn Val Ile Asn Arg Ser Tyr Lys His Leu Ile Leu 
        115                 120                 125             


Asn Ile Lys Asn Asp Ile Asn Arg Met Asn Ser Lys Lys Arg Ile Lys 
    130                 135                 140                 


Asn His Lys Gly Arg Leu Phe Leu Asp Arg Gln Lys Gln Leu Ser Lys 
145                 150                 155                 160 


Leu Lys Leu Ile Glu Gly Ser Ser Phe Phe Val Pro Ala Lys Asn Val 
                165                 170                 175     


Gly Asn Lys Ser Val Phe Thr Cys Val Ala Ile His Ser Ile Gly Arg 
            180                 185                 190         


Asp Ile Gly Ile Ala Gly Leu Tyr Asp Ser Phe Thr Lys Pro Val Asn 
        195                 200                 205             


Glu Ile Thr Tyr Gln Ile Phe Phe Ser Gly Glu Arg Arg Leu Leu Tyr 
    210                 215                 220                 


Ala Tyr Lys Pro Lys Gln Leu Lys Ile Leu Ser Ile Lys Glu Asn Leu 
225                 230                 235                 240 


Trp Ser Leu Lys Asn Glu Lys Lys Pro Leu Asp Leu Leu Tyr Glu Lys 
                245                 250                 255     


Pro Leu Gly Lys Asn Leu Asn Phe Asn Val Lys Gly Gly Asp Leu Phe 
            260                 265                 270         


Arg Val Ser Lys Asp Leu Met Ile Arg Asn Ala Lys Phe Asn Val His 
        275                 280                 285             


Gly Arg Gln Arg Leu Ser Asp Glu Glu Arg Leu Ile Asn Arg Asn Phe 
    290                 295                 300                 


Ile Lys Ile Lys Gly Glu Val Val Ser Leu Ser Tyr Gly Arg Phe Glu 
305                 310                 315                 320 


Glu Leu Lys Lys Asp Arg Lys Leu Trp Ser Pro His Ile Phe Lys Asp 
                325                 330                 335     


Val Arg Gln Asn Lys Ile Lys Pro Cys Leu Val Met Gln Gly Gln Arg 
            340                 345                 350         


Ile Asp Ile Phe Glu Gln Leu Lys Arg Lys Leu Glu Leu Leu Lys Lys 
        355                 360                 365             


Ile Arg Lys Ser Arg Gln Lys Lys Leu Ser Lys Asp Leu Ile Phe Gly 
    370                 375                 380                 


Glu Arg Ile Ala Tyr Asn Phe His Thr Lys Ser Ile Lys Asn Thr Ser 
385                 390                 395                 400 


Asn Lys Ile Asn Ile Asp Ser Asp Ala Lys Arg Gly Arg Ala Ser Tyr 
                405                 410                 415     


Met Arg Lys Arg Ile Gly Asn Glu Thr Phe Lys Leu Lys Tyr Cys Asp 
            420                 425                 430         


Val Cys Phe Pro Lys Ala Asn Val Tyr Arg Arg Val Gln Asn Gly Cys 
        435                 440                 445             


Ser Cys Ser Glu Asn Pro Tyr Asn Tyr Ile Lys Lys Gly Asp Lys Asp 
    450                 455                 460                 


Leu Leu Pro Lys Lys Asp Glu Gly Leu Ala Ile Lys Gly Ala Phe Arg 
465                 470                 475                 480 


Asp Glu Lys Leu Asn Lys Gln Ile Ile Lys Val Ala Phe Asn Ile Ala 
                485                 490                 495     


Lys Gly Tyr Glu Asp Phe Tyr Asp Asp Leu Lys Lys Arg Thr Glu Lys 
            500                 505                 510         


Asp Val Asp Leu Lys Phe Lys Ile Gly Thr Thr Val Leu Asp Gln Lys 
        515                 520                 525             


Pro Met Glu Ile Phe Asp Gly Ile Val Ile Thr Trp Leu 
    530                 535                 540     


<210> 70
<211> 542
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Leu Leu Thr Thr Val Val Glu Thr Asn Asn Leu Ala Lys Lys Ala Ile 
1               5                   10                  15      


Asn Val Ala Ala Asn Phe Asp Ala Asn Ile Asp Arg Gln Tyr Tyr Arg 
            20                  25                  30          


Cys Thr Pro Asn Leu Cys Arg Phe Ile Ala Gln Ser Pro Arg Glu Thr 
        35                  40                  45              


Lys Glu Lys Asp Ala Gly Cys Ser Ser Cys Thr Gln Ser Thr Tyr Asp 
    50                  55                  60                  


Pro Lys Val Tyr Val Ile Lys Ile Gly Lys Leu Leu Ala Lys Tyr Glu 
65                  70                  75                  80  


Ile Leu Lys Ser Leu Lys Arg Phe Leu Phe Met Asn Arg Tyr Phe Lys 
                85                  90                  95      


Gln Lys Lys Thr Glu Arg Ala Gln Gln Lys Gln Lys Ile Gly Thr Glu 
            100                 105                 110         


Leu Asn Glu Met Ser Ile Phe Ala Lys Ala Thr Asn Ala Met Glu Val 
        115                 120                 125             


Ile Lys Arg Ala Thr Lys His Cys Thr Tyr Asp Ile Ile Pro Glu Thr 
    130                 135                 140                 


Lys Ser Leu Gln Met Leu Lys Arg Arg Arg His Arg Val Lys Val Arg 
145                 150                 155                 160 


Ser Leu Leu Lys Ile Leu Lys Glu Arg Arg Met Lys Ile Lys Lys Ile 
                165                 170                 175     


Pro Asn Thr Phe Ile Glu Ile Pro Lys Gln Ala Lys Lys Asn Lys Ser 
            180                 185                 190         


Asp Tyr Tyr Val Ala Ala Ala Leu Lys Ser Cys Gly Ile Asp Val Gly 
        195                 200                 205             


Leu Cys Gly Ala Tyr Glu Lys Asn Ala Glu Val Glu Ala Glu Tyr Thr 
    210                 215                 220                 


Tyr Gln Leu Tyr Tyr Glu Tyr Lys Gly Asn Ser Ser Thr Lys Arg Ile 
225                 230                 235                 240 


Leu Tyr Cys Tyr Asn Asn Pro Gln Lys Asn Ile Arg Glu Phe Trp Glu 
                245                 250                 255     


Ala Phe Tyr Ile Gln Gly Ser Lys Ser His Val Asn Thr Pro Gly Thr 
            260                 265                 270         


Ile Arg Leu Lys Met Glu Lys Phe Leu Ser Pro Ile Thr Ile Glu Ser 
        275                 280                 285             


Glu Ala Leu Asp Phe Arg Val Trp Asn Ser Asp Leu Lys Ile Arg Asn 
    290                 295                 300                 


Gly Gln Tyr Gly Phe Ile Lys Lys Arg Ser Leu Gly Lys Glu Ala Arg 
305                 310                 315                 320 


Glu Ile Lys Lys Gly Met Gly Asp Ile Lys Arg Lys Ile Gly Asn Leu 
                325                 330                 335     


Thr Tyr Gly Lys Ser Pro Ser Glu Leu Lys Ser Ile His Val Tyr Arg 
            340                 345                 350         


Thr Glu Arg Glu Asn Pro Lys Lys Pro Arg Ala Ala Arg Lys Lys Glu 
        355                 360                 365             


Asp Asn Phe Met Glu Ile Phe Glu Met Gln Arg Lys Lys Asp Tyr Glu 
    370                 375                 380                 


Val Asn Lys Lys Arg Arg Lys Glu Ala Thr Asp Ala Ala Lys Ile Met 
385                 390                 395                 400 


Asp Phe Ala Glu Glu Pro Ile Arg His Tyr His Thr Asn Asn Leu Lys 
                405                 410                 415     


Ala Val Arg Arg Ile Asp Met Asn Glu Gln Val Glu Arg Lys Lys Thr 
            420                 425                 430         


Ser Val Phe Leu Lys Arg Ile Met Gln Asn Gly Tyr Arg Gly Asn Tyr 
        435                 440                 445             


Cys Arg Lys Cys Ile Lys Ala Pro Glu Gly Ser Asn Arg Asp Glu Asn 
    450                 455                 460                 


Val Leu Glu Lys Asn Glu Gly Cys Leu Asp Cys Ile Gly Ser Glu Phe 
465                 470                 475                 480 


Ile Trp Lys Lys Ser Ser Lys Glu Lys Lys Gly Leu Trp His Thr Asn 
                485                 490                 495     


Arg Leu Leu Arg Arg Ile Arg Leu Gln Cys Phe Thr Thr Ala Lys Ala 
            500                 505                 510         


Tyr Glu Asn Phe Tyr Asn Asp Leu Phe Glu Lys Lys Glu Ser Ser Leu 
        515                 520                 525             


Asp Ile Ile Lys Leu Lys Val Ser Ile Thr Thr Lys Ser Met 
    530                 535                 540         


<210> 71
<211> 564
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Ala Ser Thr Met Asn Leu Ala Lys Gln Ala Ile Asn Phe Ala Ala Asn 
1               5                   10                  15      


Tyr Asp Ser Asn Leu Glu Ile Gly Cys Lys Gly Cys Lys Phe Met Ser 
            20                  25                  30          


Thr Trp Ser Lys Lys Ser Asn Pro Lys Phe Tyr Pro Arg Gln Asn Asn 
        35                  40                  45              


Gln Ala Asn Lys Cys His Ser Cys Thr Tyr Ser Thr Gly Glu Pro Glu 
    50                  55                  60                  


Val Pro Ile Ile Glu Ile Gly Glu Arg Ala Ala Lys Tyr Lys Ile Phe 
65                  70                  75                  80  


Thr Ala Leu Lys Lys Phe Val Phe Met Ser Val Ala Tyr Lys Glu Arg 
                85                  90                  95      


Arg Arg Gln Arg Phe Lys Ser Lys Lys Pro Lys Glu Leu Lys Glu Leu 
            100                 105                 110         


Ala Ile Cys Ser Asn Arg Glu Lys Ala Met Glu Val Ile Gln Lys Ser 
        115                 120                 125             


Val Val His Cys Tyr Gly Asp Val Lys Gln Glu Ile Pro Arg Ile Arg 
    130                 135                 140                 


Lys Ile Lys Val Leu Lys Asn His Lys Gly Arg Leu Phe Tyr Lys Gln 
145                 150                 155                 160 


Lys Arg Ser Lys Ile Lys Ile Ala Lys Leu Glu Lys Gly Ser Phe Phe 
                165                 170                 175     


Lys Thr Phe Ile Pro Lys Val His Asn Asn Gly Cys His Ser Cys His 
            180                 185                 190         


Glu Ala Ser Leu Asn Lys Pro Ile Leu Val Thr Thr Ala Leu Asn Thr 
        195                 200                 205             


Ile Gly Ala Asp Ile Gly Leu Ile Asn Asp Tyr Ser Thr Ile Ala Pro 
    210                 215                 220                 


Thr Glu Thr Asp Ile Ser Trp Gln Val Tyr Tyr Glu Phe Ile Pro Asn 
225                 230                 235                 240 


Gly Asp Ser Glu Ala Val Lys Lys Arg Leu Leu Tyr Phe Tyr Lys Pro 
                245                 250                 255     


Lys Gly Ala Leu Ile Lys Ser Ile Arg Asp Lys Tyr Phe Lys Lys Gly 
            260                 265                 270         


His Glu Asn Ala Val Asn Thr Gly Phe Phe Lys Tyr Gln Gly Lys Ile 
        275                 280                 285             


Val Lys Gly Pro Ile Lys Phe Val Asn Asn Glu Leu Asp Phe Ala Arg 
    290                 295                 300                 


Lys Pro Asp Leu Lys Ser Met Lys Ile Lys Arg Ala Gly Phe Ala Ile 
305                 310                 315                 320 


Pro Ser Ala Lys Arg Leu Ser Lys Glu Asp Arg Glu Ile Asn Arg Glu 
                325                 330                 335     


Ser Ile Lys Ile Lys Asn Lys Ile Tyr Ser Leu Ser Tyr Gly Arg Lys 
            340                 345                 350         


Lys Thr Leu Ser Asp Lys Asp Ile Ile Lys His Leu Tyr Arg Pro Val 
        355                 360                 365             


Arg Gln Lys Gly Val Lys Pro Leu Glu Tyr Arg Lys Ala Pro Asp Gly 
    370                 375                 380                 


Phe Leu Glu Phe Phe Tyr Ser Leu Lys Arg Lys Glu Arg Arg Leu Arg 
385                 390                 395                 400 


Lys Gln Lys Glu Lys Arg Gln Lys Asp Met Ser Glu Ile Ile Asp Ala 
                405                 410                 415     


Ala Asp Glu Phe Ala Trp His Arg His Thr Gly Ser Ile Lys Lys Thr 
            420                 425                 430         


Thr Asn His Ile Asn Phe Lys Ser Glu Val Lys Arg Gly Lys Val Pro 
        435                 440                 445             


Ile Met Lys Lys Arg Ile Ala Asn Asp Ser Phe Asn Thr Arg His Cys 
    450                 455                 460                 


Gly Lys Cys Val Lys Gln Gly Asn Ala Ile Asn Lys Tyr Tyr Ile Glu 
465                 470                 475                 480 


Lys Gln Lys Asn Cys Phe Asp Cys Asn Ser Ile Glu Phe Lys Trp Glu 
                485                 490                 495     


Lys Ala Ala Leu Glu Lys Lys Gly Ala Phe Lys Leu Asn Lys Arg Leu 
            500                 505                 510         


Gln Tyr Ile Val Lys Ala Cys Phe Asn Val Ala Lys Ala Tyr Glu Ser 
        515                 520                 525             


Phe Tyr Glu Asp Phe Arg Lys Gly Glu Glu Glu Ser Leu Asp Leu Lys 
    530                 535                 540                 


Phe Lys Ile Gly Thr Thr Thr Thr Leu Lys Gln Tyr Pro Gln Asn Lys 
545                 550                 555                 560 


Ala Arg Ala Met 
                


<210> 72
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
His Ser His Asn Leu Met Leu Thr Lys Leu Gly Lys Gln Ala Ile Asn 
1               5                   10                  15      


Phe Ala Ala Asn Tyr Asp Ala Asn Leu Glu Ile Gly Cys Lys Asn Cys 
            20                  25                  30          


Lys Phe Leu Ser Tyr Ser Pro Lys Gln Ala Asn Pro Lys Lys Tyr Pro 
        35                  40                  45              


Arg Gln Thr Asp Val His Glu Asp Gly Asn Ile Ala Cys His Ser Cys 
    50                  55                  60                  


Met Gln Ser Thr Lys Glu Pro Pro Val Tyr Ile Val Pro Ile Gly Glu 
65                  70                  75                  80  


Arg Lys Ser Lys Tyr Glu Ile Leu Thr Ser Leu Asn Lys Phe Thr Phe 
                85                  90                  95      


Leu Ala Leu Lys Tyr Lys Glu Lys Lys Arg Gln Ala Phe Arg Ala Lys 
            100                 105                 110         


Lys Pro Lys Glu Leu Gln Glu Leu Ala Ile Ala Phe Asn Lys Glu Lys 
        115                 120                 125             


Ala Ile Lys Val Ile Asp Lys Ser Ile Gln His Leu Ile Leu Asn Ile 
    130                 135                 140                 


Lys Pro Glu Ile Ala Arg Ile Gln Arg Gln Lys Arg Leu Lys Asn Arg 
145                 150                 155                 160 


Lys Gly Lys Leu Leu Tyr Leu His Lys Arg Tyr Ala Ile Lys Met Gly 
                165                 170                 175     


Leu Ile Lys Asn Gly Lys Tyr Phe Lys Val Gly Ser Pro Lys Lys Asp 
            180                 185                 190         


Gly Lys Lys Leu Leu Val Leu Cys Ala Leu Asn Thr Ile Gly Arg Asp 
        195                 200                 205             


Ile Gly Ile Ile Gly Asn Ile Glu Glu Asn Asn Arg Ser Glu Thr Glu 
    210                 215                 220                 


Ile Thr Tyr Gln Leu Tyr Phe Asp Cys Leu Asp Ala Asn Pro Asn Glu 
225                 230                 235                 240 


Leu Arg Ile Lys Glu Ile Glu Tyr Asn Arg Leu Lys Ser Tyr Glu Arg 
                245                 250                 255     


Lys Ile Lys Arg Leu Val Tyr Ala Tyr Lys Pro Lys Gln Thr Lys Ile 
            260                 265                 270         


Leu Glu Ile Arg Ser Lys Phe Phe Ser Lys Gly His Glu Asn Lys Val 
        275                 280                 285             


Asn Thr Gly Ser Phe Asn Phe Glu Asn Pro Leu Asn Lys Ser Ile Ser 
    290                 295                 300                 


Ile Lys Val Lys Asn Ser Ala Phe Asp Phe Lys Ile Gly Ala Pro Phe 
305                 310                 315                 320 


Ile Met Leu Arg Asn Gly Lys Phe His Ile Pro Thr Lys Lys Arg Leu 
                325                 330                 335     


Ser Lys Glu Glu Arg Glu Ile Asn Arg Thr Leu Ser Lys Ile Lys Gly 
            340                 345                 350         


Arg Val Phe Arg Leu Thr Tyr Gly Arg Asn Ile Ser Glu Gln Gly Ser 
        355                 360                 365             


Lys Ser Leu His Ile Tyr Arg Lys Glu Arg Gln His Pro Lys Leu Ser 
    370                 375                 380                 


Leu Glu Ile Arg Lys Gln Pro Asp Ser Phe Ile Asp Glu Phe Glu Lys 
385                 390                 395                 400 


Leu Arg Leu Lys Gln Asn Phe Ile Ser Lys Leu Lys Lys Gln Arg Gln 
                405                 410                 415     


Lys Lys Leu Ala Asp Leu Leu Gln Phe Ala Asp Arg Ile Ala Tyr Asn 
            420                 425                 430         


Tyr His Thr Ser Ser Leu Glu Lys Thr Ser Asn Phe Ile Asn Tyr Lys 
        435                 440                 445             


Pro Glu Val Lys Arg Gly Arg Thr Ser Tyr Ile Lys Lys Arg Ile Gly 
    450                 455                 460                 


Asn Glu Gly Phe Glu Lys Leu Tyr Cys Glu Thr Cys Ile Lys Ser Asn 
465                 470                 475                 480 


Asp Lys Glu Asn Ala Tyr Ala Val Glu Lys Glu Glu Leu Cys Phe Val 
                485                 490                 495     


Cys Lys Ala Lys Pro Phe Thr Trp Lys Lys Thr Asn Lys Asp Lys Leu 
            500                 505                 510         


Gly Ile Phe Lys Tyr Pro Ser Arg Ile Lys Asp Phe Ile Arg Ala Ala 
        515                 520                 525             


Phe Thr Val Ala Lys Ser Tyr Asn Asp Phe Tyr Glu Asn Leu Lys Lys 
    530                 535                 540                 


Lys Asp Leu Lys Asn Glu Ile Phe Leu Lys Phe Lys Ile Gly Leu Ile 
545                 550                 555                 560 


Leu Ser His Glu Lys Lys Asn His Ile Ser Ile Ala Lys Ser Val Ala 
                565                 570                 575     


Glu Asp Glu Arg Ile Ser Gly Lys Ser Ile Lys Asn Ile Leu Asn Lys 
            580                 585                 590         


Ser Ile Lys Leu Glu Lys Asn Cys Tyr Ser Cys Phe Phe His Lys Glu 
        595                 600                 605             


Asp Met 
    610 


<210> 73
<211> 552
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Ser Leu Glu Arg Val Ile Asp Lys Arg Asn Leu Ala Lys Lys Ala Ile 
1               5                   10                  15      


Asn Ile Ala Ala Asn Phe Asp Ala Asn Ile Asn Lys Gly Phe Tyr Arg 
            20                  25                  30          


Cys Glu Thr Asn Gln Cys Met Phe Ile Ala Gln Lys Pro Arg Lys Thr 
        35                  40                  45              


Asn Asn Thr Gly Cys Ser Ser Cys Leu Gln Ser Thr Tyr Asp Pro Val 
    50                  55                  60                  


Ile Tyr Val Val Lys Val Gly Glu Met Leu Ala Lys Tyr Glu Ile Leu 
65                  70                  75                  80  


Lys Ser Leu Lys Arg Phe Val Phe Met Asn Arg Ser Phe Lys Gln Lys 
                85                  90                  95      


Lys Thr Glu Lys Ala Lys Gln Lys Glu Arg Ile Gly Gly Glu Leu Asn 
            100                 105                 110         


Glu Met Ser Ile Phe Ala Asn Ala Ala Leu Ala Met Gly Val Ile Lys 
        115                 120                 125             


Arg Ala Ile Arg His Cys His Val Asp Ile Arg Pro Glu Ile Asn Arg 
    130                 135                 140                 


Leu Ser Glu Leu Lys Lys Thr Lys His Arg Val Ala Ala Lys Ser Leu 
145                 150                 155                 160 


Val Lys Ile Val Lys Gln Arg Lys Thr Lys Trp Lys Gly Ile Pro Asn 
                165                 170                 175     


Ser Phe Ile Gln Ile Pro Gln Lys Ala Arg Asn Lys Asp Ala Asp Phe 
            180                 185                 190         


Tyr Val Ala Ser Ala Leu Lys Ser Gly Gly Ile Asp Ile Gly Leu Cys 
        195                 200                 205             


Gly Thr Tyr Asp Lys Lys Pro His Ala Asp Pro Arg Trp Thr Tyr Gln 
    210                 215                 220                 


Leu Tyr Phe Asp Thr Glu Asp Glu Ser Glu Lys Arg Leu Leu Tyr Cys 
225                 230                 235                 240 


Tyr Asn Asp Pro Gln Ala Lys Ile Arg Asp Phe Trp Lys Thr Phe Tyr 
                245                 250                 255     


Glu Arg Gly Asn Pro Ser Met Val Asn Ser Pro Gly Thr Ile Glu Phe 
            260                 265                 270         


Arg Met Glu Gly Phe Phe Glu Lys Met Thr Pro Ile Ser Ile Glu Ser 
        275                 280                 285             


Lys Asp Phe Asp Phe Arg Val Trp Asn Lys Asp Leu Leu Ile Arg Arg 
    290                 295                 300                 


Gly Leu Tyr Glu Ile Lys Lys Arg Lys Asn Leu Asn Arg Lys Ala Arg 
305                 310                 315                 320 


Glu Ile Lys Lys Ala Met Gly Ser Val Lys Arg Val Leu Ala Asn Met 
                325                 330                 335     


Thr Tyr Gly Lys Ser Pro Thr Asp Lys Lys Ser Ile Pro Val Tyr Arg 
            340                 345                 350         


Val Glu Arg Glu Lys Pro Lys Lys Pro Arg Ala Val Arg Lys Glu Glu 
        355                 360                 365             


Asn Glu Leu Ala Asp Lys Leu Glu Asn Tyr Arg Arg Glu Asp Phe Leu 
    370                 375                 380                 


Ile Arg Asn Arg Arg Lys Arg Glu Ala Thr Glu Ile Ala Lys Ile Ile 
385                 390                 395                 400 


Asp Ala Ala Glu Pro Pro Ile Arg His Tyr His Thr Asn His Leu Arg 
                405                 410                 415     


Ala Val Lys Arg Ile Asp Leu Ser Lys Pro Val Ala Arg Lys Asn Thr 
            420                 425                 430         


Ser Val Phe Leu Lys Arg Ile Met Gln Asn Gly Tyr Arg Gly Asn Tyr 
        435                 440                 445             


Cys Lys Lys Cys Ile Lys Gly Asn Ile Asp Pro Asn Lys Asp Glu Cys 
    450                 455                 460                 


Arg Leu Glu Asp Ile Lys Lys Cys Ile Cys Cys Glu Gly Thr Gln Asn 
465                 470                 475                 480 


Ile Trp Ala Lys Lys Glu Lys Leu Tyr Thr Gly Arg Ile Asn Val Leu 
                485                 490                 495     


Asn Lys Arg Ile Lys Gln Met Lys Leu Glu Cys Phe Asn Val Ala Lys 
            500                 505                 510         


Ala Tyr Glu Asn Phe Tyr Asp Asn Leu Ala Ala Leu Lys Glu Gly Asp 
        515                 520                 525             


Leu Lys Val Leu Lys Leu Lys Val Ser Ile Pro Ala Leu Asn Pro Glu 
    530                 535                 540                 


Ala Ser Asp Pro Glu Glu Asp Met 
545                 550         


<210> 74
<211> 534
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Asn Ala Ser Ile Asn Leu Gly Lys Arg Ala Ile Asn Leu Ser Ala Asn 
1               5                   10                  15      


Tyr Asp Ser Asn Leu Val Ile Gly Cys Lys Asn Cys Lys Phe Leu Ser 
            20                  25                  30          


Phe Asn Gly Asn Phe Pro Arg Gln Thr Asn Val Arg Glu Gly Cys His 
        35                  40                  45              


Ser Cys Asp Lys Ser Thr Tyr Ala Pro Glu Val Tyr Ile Val Lys Ile 
    50                  55                  60                  


Gly Glu Arg Lys Ala Lys Tyr Asp Val Leu Asp Ser Leu Lys Lys Phe 
65                  70                  75                  80  


Thr Phe Gln Ser Leu Lys Tyr Gln Ile Lys Lys Ser Met Arg Glu Arg 
                85                  90                  95      


Ser Lys Lys Pro Lys Glu Leu Leu Glu Phe Val Ile Phe Ala Asn Lys 
            100                 105                 110         


Asp Lys Ala Phe Asn Val Ile Gln Lys Ser Tyr Glu His Leu Ile Leu 
        115                 120                 125             


Asn Ile Lys Gln Glu Ile Asn Arg Met Asn Gly Lys Lys Arg Ile Lys 
    130                 135                 140                 


Asn His Lys Lys Arg Leu Phe Lys Asp Arg Glu Lys Gln Leu Asn Lys 
145                 150                 155                 160 


Leu Arg Leu Ile Gly Ser Ser Ser Leu Phe Phe Pro Arg Glu Asn Lys 
                165                 170                 175     


Gly Asp Lys Asp Leu Phe Thr Tyr Val Ala Ile His Ser Val Gly Arg 
            180                 185                 190         


Asp Ile Gly Val Ala Gly Ser Tyr Glu Ser His Ile Glu Pro Ile Ser 
        195                 200                 205             


Asp Leu Thr Tyr Gln Leu Phe Ile Asn Asn Glu Lys Arg Leu Leu Tyr 
    210                 215                 220                 


Ala Tyr Lys Pro Lys Gln Asn Lys Ile Ile Glu Leu Lys Glu Asn Leu 
225                 230                 235                 240 


Trp Asn Leu Lys Lys Glu Lys Lys Pro Leu Asp Leu Glu Phe Thr Lys 
                245                 250                 255     


Pro Leu Glu Lys Ser Ile Thr Phe Ser Val Lys Asn Asp Lys Leu Phe 
            260                 265                 270         


Lys Val Ser Lys Asp Leu Met Leu Arg Gln Ala Lys Phe Asn Ile Gln 
        275                 280                 285             


Gly Lys Glu Lys Leu Ser Lys Glu Glu Arg Gln Ile Asn Arg Asp Phe 
    290                 295                 300                 


Ser Lys Ile Lys Ser Asn Val Ile Ser Leu Ser Tyr Gly Arg Phe Glu 
305                 310                 315                 320 


Glu Leu Lys Lys Glu Lys Asn Ile Trp Ser Pro His Ile Tyr Arg Glu 
                325                 330                 335     


Val Lys Gln Lys Glu Ile Lys Pro Cys Ile Val Arg Lys Gly Asp Arg 
            340                 345                 350         


Ile Glu Leu Phe Glu Gln Leu Lys Arg Lys Met Asp Lys Leu Lys Lys 
        355                 360                 365             


Phe Arg Lys Glu Arg Gln Lys Lys Ile Ser Lys Asp Leu Asn Phe Ala 
    370                 375                 380                 


Glu Arg Ile Ala Tyr Asn Phe His Thr Lys Ser Ile Lys Asn Thr Ser 
385                 390                 395                 400 


Asn Lys Ile Asn Ile Asp Gln Glu Ala Lys Arg Gly Lys Ala Ser Tyr 
                405                 410                 415     


Met Arg Lys Arg Ile Gly Asn Glu Ser Phe Arg Lys Lys Tyr Cys Glu 
            420                 425                 430         


Gln Cys Phe Ser Val Gly Asn Val Tyr His Asn Val Gln Asn Gly Cys 
        435                 440                 445             


Ser Cys Phe Asp Asn Pro Ile Glu Leu Ile Lys Lys Gly Asp Glu Gly 
    450                 455                 460                 


Leu Ile Pro Lys Gly Lys Glu Asp Arg Lys Tyr Lys Gly Ala Leu Arg 
465                 470                 475                 480 


Asp Asp Asn Leu Gln Met Gln Ile Ile Arg Val Ala Phe Asn Ile Ala 
                485                 490                 495     


Lys Gly Tyr Glu Asp Phe Tyr Asn Asn Leu Lys Glu Lys Thr Glu Lys 
            500                 505                 510         


Asp Leu Lys Leu Lys Phe Lys Ile Gly Thr Thr Ile Ser Thr Gln Glu 
        515                 520                 525             


Ser Asn Asn Lys Glu Met 
    530                 


<210> 75
<211> 577
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Ser Asn Leu Ile Lys Leu Gly Lys Gln Ala Ile Asn Phe Ala Ala Asn 
1               5                   10                  15      


Tyr Asp Ala Asn Leu Glu Val Gly Cys Lys Asn Cys Lys Phe Leu Ser 
            20                  25                  30          


Ser Thr Asn Lys Tyr Pro Arg Gln Thr Asn Val His Leu Asp Asn Lys 
        35                  40                  45              


Met Ala Cys Arg Ser Cys Asn Gln Ser Thr Met Glu Pro Ala Ile Tyr 
    50                  55                  60                  


Ile Val Arg Ile Gly Glu Lys Lys Ala Lys Tyr Asp Ile Tyr Asn Ser 
65                  70                  75                  80  


Leu Thr Lys Phe Asn Phe Gln Ser Leu Lys Tyr Lys Ala Lys Arg Ser 
                85                  90                  95      


Gln Arg Phe Lys Pro Lys Gln Pro Lys Glu Leu Gln Glu Leu Ser Ile 
            100                 105                 110         


Ala Val Arg Lys Glu Lys Ala Leu Asp Ile Ile Gln Lys Ser Ile Asp 
        115                 120                 125             


His Leu Ile Gln Asp Ile Arg Pro Glu Ile Pro Arg Ile Lys Gln Gln 
    130                 135                 140                 


Lys Arg Tyr Lys Asn His Val Gly Lys Leu Phe Tyr Leu Gln Lys Arg 
145                 150                 155                 160 


Arg Lys Asn Lys Leu Asn Leu Ile Gly Lys Gly Ser Phe Phe Lys Val 
                165                 170                 175     


Phe Ser Pro Lys Glu Lys Lys Asn Glu Leu Leu Val Ile Cys Ala Leu 
            180                 185                 190         


Thr Asn Ile Gly Arg Asp Ile Gly Leu Ile Gly Asn Tyr Asn Thr Ile 
        195                 200                 205             


Ile Asn Pro Leu Phe Glu Val Thr Tyr Gln Leu Tyr Tyr Asp Tyr Ile 
    210                 215                 220                 


Pro Lys Lys Asn Asn Lys Asn Val Gln Arg Arg Leu Leu Tyr Ala Tyr 
225                 230                 235                 240 


Lys Ser Lys Asn Glu Lys Ile Leu Lys Leu Lys Glu Ala Phe Phe Lys 
                245                 250                 255     


Arg Gly His Glu Asn Ala Val Asn Leu Gly Ser Phe Ser Tyr Glu Lys 
            260                 265                 270         


Pro Leu Glu Lys Ser Leu Thr Leu Lys Ile Lys Asn Asp Lys Asp Asp 
        275                 280                 285             


Phe Gln Val Ser Pro Ser Leu Arg Ile Arg Thr Gly Arg Phe Phe Val 
    290                 295                 300                 


Pro Ser Lys Arg Asn Leu Ser Arg Gln Glu Arg Glu Ile Asn Arg Arg 
305                 310                 315                 320 


Leu Val Lys Ile Lys Ser Lys Ile Lys Asn Met Thr Tyr Gly Lys Phe 
                325                 330                 335     


Glu Thr Ala Arg Asp Lys Gln Ser Val His Ile Phe Arg Leu Glu Arg 
            340                 345                 350         


Gln Lys Glu Lys Leu Pro Leu Gln Phe Arg Lys Asp Glu Lys Glu Phe 
        355                 360                 365             


Met Glu Glu Phe Gln Lys Leu Lys Arg Arg Thr Asn Ser Leu Lys Lys 
    370                 375                 380                 


Leu Arg Lys Ser Arg Gln Lys Lys Leu Ala Asp Leu Leu Gln Leu Ser 
385                 390                 395                 400 


Glu Lys Val Val Tyr Asn Asn His Thr Gly Thr Leu Lys Lys Thr Ser 
                405                 410                 415     


Asn Phe Leu Asn Phe Ser Ser Ser Val Lys Arg Gly Lys Thr Ala Tyr 
            420                 425                 430         


Ile Lys Glu Leu Leu Gly Gln Glu Gly Phe Glu Thr Leu Tyr Cys Ser 
        435                 440                 445             


Asn Cys Ile Asn Lys Gly Gln Lys Thr Arg Tyr Asn Ile Glu Thr Lys 
    450                 455                 460                 


Glu Lys Cys Phe Ser Cys Lys Asp Val Pro Phe Val Trp Lys Lys Lys 
465                 470                 475                 480 


Ser Thr Asp Lys Asp Arg Lys Gly Ala Phe Leu Phe Pro Ala Lys Leu 
                485                 490                 495     


Lys Asp Val Ile Lys Ala Thr Phe Thr Val Ala Lys Ala Tyr Glu Asp 
            500                 505                 510         


Phe Tyr Asp Asn Leu Lys Ser Ile Asp Glu Lys Lys Pro Tyr Ile Lys 
        515                 520                 525             


Phe Lys Ile Gly Leu Ile Leu Ala His Val Arg His Glu His Lys Ala 
    530                 535                 540                 


Arg Ala Lys Glu Glu Ala Gly Gln Lys Asn Ile Tyr Asn Lys Pro Ile 
545                 550                 555                 560 


Lys Ile Asp Lys Asn Cys Lys Glu Cys Phe Phe Phe Lys Glu Glu Ala 
                565                 570                 575     


Met 
    


<210> 76
<211> 613
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Asn Thr Thr Arg Lys Lys Phe Arg Lys Arg Thr Gly Phe Pro Gln Ser 
1               5                   10                  15      


Asp Asn Ile Lys Leu Ala Tyr Cys Ser Ala Ile Val Arg Ala Ala Asn 
            20                  25                  30          


Leu Asp Ala Asp Ile Gln Lys Lys His Asn Gln Cys Asn Pro Asn Leu 
        35                  40                  45              


Cys Val Gly Ile Lys Ser Asn Glu Gln Ser Arg Lys Tyr Glu His Ser 
    50                  55                  60                  


Asp Arg Gln Ala Leu Leu Cys Tyr Ala Cys Asn Gln Ser Thr Gly Ala 
65                  70                  75                  80  


Pro Lys Val Asp Tyr Ile Gln Ile Gly Glu Ile Gly Ala Lys Tyr Lys 
                85                  90                  95      


Ile Leu Gln Met Val Asn Ala Tyr Asp Phe Leu Ser Leu Ala Tyr Asn 
            100                 105                 110         


Leu Thr Lys Leu Arg Asn Gly Lys Ser Arg Gly His Gln Arg Met Ser 
        115                 120                 125             


Gln Leu Asp Glu Val Val Ile Val Ala Asp Tyr Glu Lys Ala Thr Glu 
    130                 135                 140                 


Val Ile Lys Arg Ser Ile Asn His Leu Leu Asp Asp Ile Arg Gly Gln 
145                 150                 155                 160 


Leu Ser Lys Leu Lys Lys Arg Thr Gln Asn Glu His Ile Thr Glu His 
                165                 170                 175     


Lys Gln Ser Lys Ile Arg Arg Lys Leu Arg Lys Leu Ser Arg Leu Leu 
            180                 185                 190         


Lys Arg Arg Arg Trp Lys Trp Gly Thr Ile Pro Asn Pro Tyr Leu Lys 
        195                 200                 205             


Asn Trp Val Phe Thr Lys Lys Asp Pro Glu Leu Val Thr Val Ala Leu 
    210                 215                 220                 


Leu His Lys Leu Gly Arg Asp Ile Gly Leu Val Asn Arg Ser Lys Arg 
225                 230                 235                 240 


Arg Ser Lys Gln Lys Leu Leu Pro Lys Val Gly Phe Gln Leu Tyr Tyr 
                245                 250                 255     


Lys Trp Glu Ser Pro Ser Leu Asn Asn Ile Lys Lys Ser Lys Ala Lys 
            260                 265                 270         


Lys Leu Pro Lys Arg Leu Leu Ile Pro Tyr Lys Asn Val Lys Leu Phe 
        275                 280                 285             


Asp Asn Lys Gln Lys Leu Glu Asn Ala Ile Lys Ser Leu Leu Glu Ser 
    290                 295                 300                 


Tyr Gln Lys Thr Ile Lys Val Glu Phe Asp Gln Phe Phe Gln Asn Arg 
305                 310                 315                 320 


Thr Glu Glu Ile Ile Ala Glu Glu Gln Gln Thr Leu Glu Arg Gly Leu 
                325                 330                 335     


Leu Lys Gln Leu Glu Lys Lys Lys Asn Glu Phe Ala Ser Gln Lys Lys 
            340                 345                 350         


Ala Leu Lys Glu Glu Lys Lys Lys Ile Lys Glu Pro Arg Lys Ala Lys 
        355                 360                 365             


Leu Leu Met Glu Glu Ser Arg Ser Leu Gly Phe Leu Met Ala Asn Val 
    370                 375                 380                 


Ser Tyr Ala Leu Phe Asn Thr Thr Ile Glu Asp Leu Tyr Lys Lys Ser 
385                 390                 395                 400 


Asn Val Val Ser Gly Cys Ile Pro Gln Glu Pro Val Val Val Phe Pro 
                405                 410                 415     


Ala Asp Ile Gln Asn Lys Gly Ser Leu Ala Lys Ile Leu Phe Ala Pro 
            420                 425                 430         


Lys Asp Gly Phe Arg Ile Lys Phe Ser Gly Gln His Leu Thr Ile Arg 
        435                 440                 445             


Thr Ala Lys Phe Lys Ile Arg Gly Lys Glu Ile Lys Ile Leu Thr Lys 
    450                 455                 460                 


Thr Lys Arg Glu Ile Leu Lys Asn Ile Glu Lys Leu Arg Arg Val Trp 
465                 470                 475                 480 


Tyr Arg Glu Gln His Tyr Lys Leu Lys Leu Phe Gly Lys Glu Val Ser 
                485                 490                 495     


Ala Lys Pro Arg Phe Leu Asp Lys Arg Lys Thr Ser Ile Glu Arg Arg 
            500                 505                 510         


Asp Pro Asn Lys Leu Ala Asp Gln Thr Asp Asp Arg Gln Ala Glu Leu 
        515                 520                 525             


Arg Asn Lys Glu Tyr Glu Leu Arg His Lys Gln His Lys Met Ala Glu 
    530                 535                 540                 


Arg Leu Asp Asn Ile Asp Thr Asn Ala Gln Asn Leu Gln Thr Leu Ser 
545                 550                 555                 560 


Phe Trp Val Gly Glu Ala Asp Lys Pro Pro Lys Leu Asp Glu Lys Asp 
                565                 570                 575     


Ala Arg Gly Phe Gly Val Arg Thr Cys Ile Ser Ala Trp Lys Trp Phe 
            580                 585                 590         


Met Glu Asp Leu Leu Lys Lys Gln Glu Glu Asp Pro Leu Leu Lys Leu 
        595                 600                 605             


Lys Leu Ser Ile Met 
    610             


<210> 77
<211> 615
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Pro Lys Lys Pro Lys Phe Gln Lys Arg Thr Gly Phe Pro Gln Pro Asp 
1               5                   10                  15      


Asn Leu Arg Lys Glu Tyr Cys Leu Ala Ile Val Arg Ala Ala Asn Leu 
            20                  25                  30          


Asp Ala Asp Phe Glu Lys Lys Cys Thr Lys Cys Glu Gly Ile Lys Thr 
        35                  40                  45              


Asn Lys Lys Gly Asn Ile Val Lys Gly Arg Thr Tyr Asn Ser Ala Asp 
    50                  55                  60                  


Lys Asp Asn Leu Leu Cys Tyr Ala Cys Asn Ile Ser Thr Gly Ala Pro 
65                  70                  75                  80  


Ala Val Asp Tyr Val Phe Val Gly Ala Leu Glu Ala Lys Tyr Lys Ile 
                85                  90                  95      


Leu Gln Met Val Lys Ala Tyr Asp Phe His Ser Leu Ala Tyr Asn Leu 
            100                 105                 110         


Ala Lys Leu Trp Lys Gly Arg Gly Arg Gly His Gln Arg Met Gly Gly 
        115                 120                 125             


Leu Asn Glu Val Val Ile Val Ser Asn Asn Glu Lys Ala Leu Asp Val 
    130                 135                 140                 


Ile Glu Lys Ser Leu Asn His Phe His Asp Glu Ile Arg Gly Glu Leu 
145                 150                 155                 160 


Ser Arg Leu Lys Ala Lys Phe Gln Asn Glu His Leu His Val His Lys 
                165                 170                 175     


Glu Ser Lys Leu Arg Arg Lys Leu Arg Lys Ile Ser Arg Leu Leu Lys 
            180                 185                 190         


Arg Arg Arg Trp Lys Trp Asp Val Ile Pro Asn Ser Tyr Leu Arg Asn 
        195                 200                 205             


Phe Thr Phe Thr Lys Thr Arg Pro Asp Phe Ile Ser Val Ala Leu Leu 
    210                 215                 220                 


His Arg Val Gly Arg Asp Ile Gly Leu Val Thr Lys Thr Lys Ile Pro 
225                 230                 235                 240 


Lys Pro Thr Asp Leu Leu Pro Gln Phe Gly Phe Gln Ile Tyr Tyr Thr 
                245                 250                 255     


Trp Asp Glu Pro Lys Leu Asn Lys Leu Lys Lys Ser Arg Leu Arg Ser 
            260                 265                 270         


Glu Pro Lys Arg Leu Leu Val Pro Tyr Lys Lys Ile Glu Leu Tyr Lys 
        275                 280                 285             


Asn Lys Ser Val Leu Glu Glu Ala Ile Arg His Leu Ala Glu Val Tyr 
    290                 295                 300                 


Thr Glu Asp Leu Thr Ile Cys Phe Lys Asp Phe Phe Glu Thr Gln Lys 
305                 310                 315                 320 


Arg Lys Phe Val Ser Lys Glu Lys Glu Ser Leu Lys Arg Glu Leu Leu 
                325                 330                 335     


Lys Glu Leu Thr Lys Leu Lys Lys Asp Phe Ser Glu Arg Lys Thr Ala 
            340                 345                 350         


Leu Lys Arg Asp Arg Lys Glu Ile Lys Glu Pro Lys Lys Ala Lys Leu 
        355                 360                 365             


Leu Met Glu Glu Ser Arg Ser Leu Gly Phe Leu Ala Ala Asn Thr Ser 
    370                 375                 380                 


Tyr Ala Leu Phe Asn Leu Ile Ala Ala Asp Leu Tyr Thr Lys Ser Lys 
385                 390                 395                 400 


Lys Ala Cys Ser Thr Lys Leu Pro Arg Gln Leu Ser Thr Ile Leu Pro 
                405                 410                 415     


Leu Glu Ile Lys Glu His Lys Ser Thr Thr Ser Leu Ala Ile Lys Pro 
            420                 425                 430         


Glu Glu Gly Phe Lys Ile Arg Phe Ser Asn Thr His Leu Ser Ile Arg 
        435                 440                 445             


Thr Pro Lys Phe Lys Met Lys Gly Ala Asp Ile Lys Ala Leu Thr Lys 
    450                 455                 460                 


Arg Lys Arg Glu Ile Leu Lys Asn Ala Thr Lys Leu Glu Lys Ser Trp 
465                 470                 475                 480 


Tyr Gly Leu Lys His Tyr Lys Leu Lys Leu Tyr Gly Lys Glu Val Ala 
                485                 490                 495     


Ala Lys Pro Arg Phe Leu Asp Lys Arg Asn Pro Ser Ile Asp Arg Arg 
            500                 505                 510         


Asp Pro Lys Glu Leu Met Glu Gln Ile Glu Asn Arg Arg Asn Glu Val 
        515                 520                 525             


Lys Asp Leu Glu Tyr Glu Ile Arg Lys Gly Gln His Gln Met Ala Lys 
    530                 535                 540                 


Arg Leu Asp Asn Val Asp Thr Asn Ala Gln Asn Leu Gln Thr Lys Ser 
545                 550                 555                 560 


Phe Trp Val Gly Glu Ala Asp Lys Pro Pro Glu Leu Asp Ser Met Glu 
                565                 570                 575     


Ala Lys Lys Leu Gly Leu Arg Thr Cys Ile Ser Ala Trp Lys Trp Phe 
            580                 585                 590         


Met Lys Asp Leu Val Leu Leu Gln Glu Lys Ser Pro Asn Leu Lys Leu 
        595                 600                 605             


Lys Leu Ser Leu Thr Glu Met 
    610                 615 


<210> 78
<211> 775
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Lys Phe Ser Lys Arg Gln Glu Gly Phe Leu Ile Pro Asp Asn Ile Asp 
1               5                   10                  15      


Leu Tyr Lys Cys Leu Ala Ile Val Arg Ser Ala Asn Leu Asp Ala Asp 
            20                  25                  30          


Val Gln Gly His Lys Ser Cys Tyr Gly Val Lys Lys Asn Gly Thr Tyr 
        35                  40                  45              


Arg Val Lys Gln Asn Gly Lys Lys Gly Val Lys Glu Lys Gly Arg Lys 
    50                  55                  60                  


Tyr Val Phe Asp Leu Ile Ala Phe Lys Gly Asn Ile Glu Lys Ile Pro 
65                  70                  75                  80  


His Glu Ala Ile Glu Glu Lys Asp Gln Gly Arg Val Ile Val Leu Gly 
                85                  90                  95      


Lys Phe Asn Tyr Lys Leu Ile Leu Asn Ile Glu Lys Asn His Asn Asp 
            100                 105                 110         


Arg Ala Ser Leu Glu Ile Lys Asn Lys Ile Lys Lys Leu Val Gln Ile 
        115                 120                 125             


Ser Ser Leu Glu Thr Gly Glu Phe Leu Ser Asp Leu Leu Ser Gly Lys 
    130                 135                 140                 


Ile Gly Ile Asp Glu Val Tyr Gly Ile Ile Glu Pro Asp Val Phe Ser 
145                 150                 155                 160 


Gly Lys Glu Leu Val Cys Lys Ala Cys Gln Gln Ser Thr Tyr Ala Pro 
                165                 170                 175     


Leu Val Glu Tyr Met Pro Val Gly Glu Leu Asp Ala Lys Tyr Lys Ile 
            180                 185                 190         


Leu Ser Ala Ile Lys Gly Tyr Asp Phe Leu Ser Leu Ala Tyr Asn Leu 
        195                 200                 205             


Ser Arg Asn Arg Ala Asn Lys Lys Arg Gly His Gln Lys Leu Gly Gly 
    210                 215                 220                 


Gly Glu Leu Ser Glu Val Val Ile Ser Ala Asn Tyr Asp Lys Ala Leu 
225                 230                 235                 240 


Asn Val Ile Lys Arg Ser Ile Asn His Tyr His Val Glu Ile Lys Pro 
                245                 250                 255     


Glu Ile Ser Lys Leu Lys Lys Lys Met Gln Asn Glu Pro Leu Lys Val 
            260                 265                 270         


Met Lys Gln Ala Arg Ile Arg Arg Glu Leu His Gln Leu Ser Arg Lys 
        275                 280                 285             


Val Lys Arg Leu Lys Trp Lys Trp Gly Met Ile Pro Asn Pro Glu Leu 
    290                 295                 300                 


Gln Asn Ile Ile Phe Glu Lys Lys Glu Lys Asp Phe Val Ser Tyr Ala 
305                 310                 315                 320 


Leu Leu His Thr Leu Gly Arg Asp Ile Gly Leu Phe Lys Asp Thr Ser 
                325                 330                 335     


Met Leu Gln Val Pro Asn Ile Ser Asp Tyr Gly Phe Gln Ile Tyr Tyr 
            340                 345                 350         


Ser Trp Glu Asp Pro Lys Leu Asn Ser Ile Lys Lys Ile Lys Asp Leu 
        355                 360                 365             


Pro Lys Arg Leu Leu Ile Pro Tyr Lys Arg Leu Asp Phe Tyr Ile Asp 
    370                 375                 380                 


Thr Ile Leu Val Ala Lys Val Ile Lys Asn Leu Ile Glu Leu Tyr Arg 
385                 390                 395                 400 


Lys Ser Tyr Val Tyr Glu Thr Phe Gly Glu Glu Tyr Gly Tyr Ala Lys 
                405                 410                 415     


Lys Ala Glu Asp Ile Leu Phe Asp Trp Asp Ser Ile Asn Leu Ser Glu 
            420                 425                 430         


Gly Ile Glu Gln Lys Ile Gln Lys Ile Lys Asp Glu Phe Ser Asp Leu 
        435                 440                 445             


Leu Tyr Glu Ala Arg Glu Ser Lys Arg Gln Asn Phe Val Glu Ser Phe 
    450                 455                 460                 


Glu Asn Ile Leu Gly Leu Tyr Asp Lys Asn Phe Ala Ser Asp Arg Asn 
465                 470                 475                 480 


Ser Tyr Gln Glu Lys Ile Gln Ser Met Ile Ile Lys Lys Gln Gln Glu 
                485                 490                 495     


Asn Ile Glu Gln Lys Leu Lys Arg Glu Phe Lys Glu Val Ile Glu Arg 
            500                 505                 510         


Gly Phe Glu Gly Met Asp Gln Asn Lys Lys Tyr Tyr Lys Val Leu Ser 
        515                 520                 525             


Pro Asn Ile Lys Gly Gly Leu Leu Tyr Thr Asp Thr Asn Asn Leu Gly 
    530                 535                 540                 


Phe Phe Arg Ser His Leu Ala Phe Met Leu Leu Ser Lys Ile Ser Asp 
545                 550                 555                 560 


Asp Leu Tyr Arg Lys Asn Asn Leu Val Ser Lys Gly Gly Asn Lys Gly 
                565                 570                 575     


Ile Leu Asp Gln Thr Pro Glu Thr Met Leu Thr Leu Glu Phe Gly Lys 
            580                 585                 590         


Ser Asn Leu Pro Asn Ile Ser Ile Lys Arg Lys Phe Phe Asn Ile Lys 
        595                 600                 605             


Tyr Asn Ser Ser Trp Ile Gly Ile Arg Lys Pro Lys Phe Ser Ile Lys 
    610                 615                 620                 


Gly Ala Val Ile Arg Glu Ile Thr Lys Lys Val Arg Asp Glu Gln Arg 
625                 630                 635                 640 


Leu Ile Lys Ser Leu Glu Gly Val Trp His Lys Ser Thr His Phe Lys 
                645                 650                 655     


Arg Trp Gly Lys Pro Arg Phe Asn Leu Pro Arg His Pro Asp Arg Glu 
            660                 665                 670         


Lys Asn Asn Asp Asp Asn Leu Met Glu Ser Ile Thr Ser Arg Arg Glu 
        675                 680                 685             


Gln Ile Gln Leu Leu Leu Arg Glu Lys Gln Lys Gln Gln Glu Lys Met 
    690                 695                 700                 


Ala Gly Arg Leu Asp Lys Ile Asp Lys Glu Ile Gln Asn Leu Gln Thr 
705                 710                 715                 720 


Ala Asn Phe Gln Ile Lys Gln Ile Asp Lys Lys Pro Ala Leu Thr Glu 
                725                 730                 735     


Lys Ser Glu Gly Lys Gln Ser Val Arg Asn Ala Leu Ser Ala Trp Lys 
            740                 745                 750         


Trp Phe Met Glu Asp Leu Ile Lys Tyr Gln Lys Arg Thr Pro Ile Leu 
        755                 760                 765             


Gln Leu Lys Leu Ala Lys Met 
    770                 775 


<210> 79
<211> 777
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 79
Lys Phe Ser Lys Arg Gln Glu Gly Phe Val Ile Pro Glu Asn Ile Gly 
1               5                   10                  15      


Leu Tyr Lys Cys Leu Ala Ile Val Arg Ser Ala Asn Leu Asp Ala Asp 
            20                  25                  30          


Val Gln Gly His Val Ser Cys Tyr Gly Val Lys Lys Asn Gly Thr Tyr 
        35                  40                  45              


Val Leu Lys Gln Asn Gly Lys Lys Ser Ile Arg Glu Lys Gly Arg Lys 
    50                  55                  60                  


Tyr Ala Ser Asp Leu Val Ala Phe Lys Gly Asp Ile Glu Lys Ile Pro 
65                  70                  75                  80  


Phe Glu Val Ile Glu Glu Lys Lys Lys Glu Gln Ser Ile Val Leu Gly 
                85                  90                  95      


Lys Phe Asn Tyr Lys Leu Val Leu Asp Val Met Lys Gly Glu Lys Asp 
            100                 105                 110         


Arg Ala Ser Leu Thr Met Lys Asn Lys Ser Lys Lys Leu Val Gln Val 
        115                 120                 125             


Ser Ser Leu Gly Thr Asp Glu Phe Leu Leu Thr Leu Leu Asn Glu Lys 
    130                 135                 140                 


Phe Gly Ile Glu Glu Ile Tyr Gly Ile Ile Glu Pro Glu Val Phe Ser 
145                 150                 155                 160 


Gly Lys Lys Leu Val Cys Lys Ala Cys Gln Gln Ser Thr Tyr Ala Pro 
                165                 170                 175     


Leu Val Glu Tyr Met Pro Val Gly Glu Leu Asp Ser Lys Tyr Lys Ile 
            180                 185                 190         


Leu Ser Ala Ile Lys Gly Tyr Asp Phe Leu Ser Leu Ala Tyr Asn Leu 
        195                 200                 205             


Ala Arg His Arg Ser Asn Lys Lys Arg Gly His Gln Lys Leu Gly Gly 
    210                 215                 220                 


Gly Glu Leu Ser Glu Val Val Ile Ser Ala Asn Asn Ala Lys Ala Leu 
225                 230                 235                 240 


Asn Val Ile Lys Arg Ser Leu Asn His Tyr Tyr Ser Glu Ile Lys Pro 
                245                 250                 255     


Glu Ile Ser Lys Leu Arg Lys Lys Met Gln Asn Glu Pro Leu Lys Val 
            260                 265                 270         


Gly Lys Gln Ala Arg Met Arg Arg Glu Leu His Gln Leu Ser Arg Lys 
        275                 280                 285             


Val Lys Arg Leu Lys Trp Lys Trp Gly Lys Ile Pro Asn Leu Glu Leu 
    290                 295                 300                 


Gln Asn Ile Thr Phe Lys Glu Ser Asp Arg Asp Phe Ile Ser Tyr Ala 
305                 310                 315                 320 


Leu Leu His Thr Leu Gly Arg Asp Ile Gly Met Phe Asn Lys Thr Glu 
                325                 330                 335     


Ile Lys Met Pro Ser Asn Ile Leu Gly Tyr Gly Phe Gln Ile Tyr Tyr 
            340                 345                 350         


Asp Trp Glu Glu Pro Lys Leu Asn Thr Ile Lys Lys Ser Lys Asn Thr 
        355                 360                 365             


Pro Lys Arg Ile Leu Ile Pro Tyr Lys Lys Leu Asp Phe Tyr Asn Asp 
    370                 375                 380                 


Ser Ile Leu Val Ala Arg Ala Ile Lys Glu Leu Val Gly Leu Phe Gln 
385                 390                 395                 400 


Glu Ser Tyr Glu Trp Glu Ile Phe Gly Asn Glu Tyr Asn Tyr Ala Lys 
                405                 410                 415     


Glu Ala Glu Val Glu Leu Ile Lys Leu Asp Glu Glu Ser Ile Asn Gly 
            420                 425                 430         


Asn Val Glu Lys Lys Leu Gln Arg Ile Lys Glu Asn Phe Ser Asn Leu 
        435                 440                 445             


Leu Glu Lys Ala Arg Glu Lys Lys Arg Gln Asn Phe Ile Glu Ser Phe 
    450                 455                 460                 


Glu Ser Ile Ala Arg Leu Tyr Asp Glu Ser Phe Thr Ala Asp Arg Asn 
465                 470                 475                 480 


Glu Tyr Gln Arg Glu Ile Gln Ser Phe Ile Ile Glu Lys Gln Lys Gln 
                485                 490                 495     


Ser Ile Glu Lys Lys Leu Lys Asn Glu Phe Lys Lys Ile Val Glu Lys 
            500                 505                 510         


Lys Phe Asn Glu Gln Glu Gln Gly Lys Lys His Tyr Arg Val Leu Asn 
        515                 520                 525             


Pro Thr Ile Ile Asn Glu Phe Leu Pro Lys Asp Lys Asn Asn Leu Gly 
    530                 535                 540                 


Phe Leu Arg Ser Lys Ile Ala Phe Ile Leu Leu Ser Lys Ile Ser Asp 
545                 550                 555                 560 


Asp Leu Tyr Lys Lys Ser Asn Ala Val Ser Lys Gly Gly Glu Lys Gly 
                565                 570                 575     


Ile Ile Lys Gln Gln Pro Glu Thr Ile Leu Asp Leu Glu Phe Ser Lys 
            580                 585                 590         


Ser Lys Leu Pro Ser Ile Asn Ile Lys Lys Lys Leu Phe Asn Ile Lys 
        595                 600                 605             


Tyr Thr Ser Ser Trp Leu Gly Ile Arg Lys Pro Lys Phe Asn Ile Lys 
    610                 615                 620                 


Gly Ala Lys Ile Arg Glu Ile Thr Arg Arg Val Arg Asp Val Gln Arg 
625                 630                 635                 640 


Thr Leu Lys Ser Ala Glu Ser Ser Trp Tyr Ala Ser Thr His Phe Arg 
                645                 650                 655     


Arg Trp Gly Phe Pro Arg Phe Asn Gln Pro Arg His Pro Asp Lys Glu 
            660                 665                 670         


Lys Lys Ser Asp Asp Arg Leu Ile Glu Ser Ile Thr Leu Leu Arg Glu 
        675                 680                 685             


Gln Ile Gln Ile Leu Leu Arg Glu Lys Gln Lys Gly Gln Lys Glu Met 
    690                 695                 700                 


Ala Gly Arg Leu Asp Asp Val Asp Lys Lys Ile Gln Asn Leu Gln Thr 
705                 710                 715                 720 


Ala Asn Phe Gln Ile Lys Gln Thr Gly Asp Lys Pro Ala Leu Thr Glu 
                725                 730                 735     


Lys Ser Ala Gly Lys Gln Ser Phe Arg Asn Ala Leu Ser Ala Trp Lys 
            740                 745                 750         


Trp Phe Met Glu Asn Leu Leu Lys Tyr Gln Asn Lys Thr Pro Asp Leu 
        755                 760                 765             


Lys Leu Lys Ile Ala Arg Thr Val Met 
    770                 775         


<210> 80
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Lys Trp Ile Glu Pro Asn Asn Ile Asp Phe Asn Lys Cys Leu Ala Ile 
1               5                   10                  15      


Thr Arg Ser Ala Asn Leu Asp Ala Asp Val Gln Gly His Lys Met Cys 
            20                  25                  30          


Tyr Gly Ile Lys Thr Asn Gly Thr Tyr Lys Ala Ile Gly Lys Ile Asn 
        35                  40                  45              


Lys Lys His Asn Thr Gly Ile Ile Glu Lys Arg Arg Thr Tyr Val Tyr 
    50                  55                  60                  


Asp Leu Ile Val Thr Lys Glu Lys Asn Glu Lys Ile Val Lys Lys Thr 
65                  70                  75                  80  


Asp Phe Met Ala Ile Asp Glu Glu Ile Glu Phe Asp Glu Lys Lys Glu 
                85                  90                  95      


Lys Leu Leu Lys Lys Tyr Ile Lys Ala Glu Val Leu Gly Thr Gly Glu 
            100                 105                 110         


Leu Ile Arg Lys Asp Leu Asn Asp Gly Glu Lys Phe Asp Asp Leu Cys 
        115                 120                 125             


Ser Ile Glu Glu Pro Gln Ala Phe Arg Arg Ser Glu Leu Val Cys Lys 
    130                 135                 140                 


Ala Cys Asn Gln Ser Thr Tyr Ala Ser Asp Ile Arg Tyr Ile Pro Ile 
145                 150                 155                 160 


Gly Glu Ile Glu Ala Lys Tyr Lys Ile Leu Lys Ala Ile Lys Gly Tyr 
                165                 170                 175     


Asp Phe Leu Ser Leu Lys Tyr Asn Leu Gly Arg Leu Arg Asp Ser Lys 
            180                 185                 190         


Lys Arg Gly His Gln Lys Met Gly Gln Gly Glu Leu Lys Glu Phe Val 
        195                 200                 205             


Ile Cys Ala Asn Lys Glu Lys Ala Leu Asp Val Ile Lys Arg Ser Leu 
    210                 215                 220                 


Asn His Tyr Leu Asn Glu Val Lys Asp Glu Ile Ser Arg Leu Asn Lys 
225                 230                 235                 240 


Lys Met Gln Asn Glu Pro Leu Lys Val Asn Asp Gln Ala Arg Trp Arg 
                245                 250                 255     


Arg Glu Leu Asn Gln Ile Ser Arg Arg Leu Lys Arg Leu Lys Trp Lys 
            260                 265                 270         


Trp Gly Glu Ile Pro Asn Pro Glu Leu Lys Asn Leu Ile Phe Lys Ser 
        275                 280                 285             


Ser Arg Pro Glu Phe Val Ser Tyr Ala Leu Ile His Thr Leu Gly Arg 
    290                 295                 300                 


Asp Ile Gly Leu Ile Asn Glu Thr Glu Leu Lys Pro Asn Asn Ile Gln 
305                 310                 315                 320 


Glu Tyr Gly Phe Gln Ile Tyr Tyr Lys Trp Glu Asp Pro Glu Leu Asn 
                325                 330                 335     


His Ile Lys Lys Val Lys Asn Ile Pro Lys Arg Phe Ile Ile Pro Tyr 
            340                 345                 350         


Lys Asn Leu Asp Leu Phe Gly Lys Tyr Thr Ile Leu Ser Arg Ala Ile 
        355                 360                 365             


Glu Gly Ile Leu Lys Leu Tyr Ser Ser Ser Phe Gln Tyr Lys Ser Phe 
    370                 375                 380                 


Lys Asp Pro Asn Leu Phe Ala Lys Glu Gly Glu Lys Lys Ile Thr Asn 
385                 390                 395                 400 


Glu Asp Phe Glu Leu Gly Tyr Asp Glu Lys Ile Lys Lys Ile Lys Asp 
                405                 410                 415     


Asp Phe Lys Ser Tyr Lys Lys Ala Leu Leu Glu Lys Lys Lys Asn Thr 
            420                 425                 430         


Leu Glu Asp Ser Leu Asn Ser Ile Leu Ser Val Tyr Glu Gln Ser Leu 
        435                 440                 445             


Leu Thr Glu Gln Ile Asn Asn Val Lys Lys Trp Lys Glu Gly Leu Leu 
    450                 455                 460                 


Lys Ser Lys Glu Ser Ile His Lys Gln Lys Lys Ile Glu Asn Ile Glu 
465                 470                 475                 480 


Asp Ile Ile Ser Arg Ile Glu Glu Leu Lys Asn Val Glu Gly Trp Ile 
                485                 490                 495     


Arg Thr Lys Glu Arg Asp Ile Val Asn Lys Glu Glu Thr Asn Leu Lys 
            500                 505                 510         


Arg Glu Ile Lys Lys Glu Leu Lys Asp Ser Tyr Tyr Glu Glu Val Arg 
        515                 520                 525             


Lys Asp Phe Ser Asp Leu Lys Lys Gly Glu Glu Ser Glu Lys Lys Pro 
    530                 535                 540                 


Phe Arg Glu Glu Pro Lys Pro Ile Val Ile Lys Asp Tyr Ile Lys Phe 
545                 550                 555                 560 


Asp Val Leu Pro Gly Glu Asn Ser Ala Leu Gly Phe Phe Leu Ser His 
                565                 570                 575     


Leu Ser Phe Asn Leu Phe Asp Ser Ile Gln Tyr Glu Leu Phe Glu Lys 
            580                 585                 590         


Ser Arg Leu Ser Ser Ser Lys His Pro Gln Ile Pro Glu Thr Ile Leu 
        595                 600                 605             


Asp Leu 
    610 


<210> 81
<211> 632
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 81
Phe Arg Lys Phe Val Lys Arg Ser Gly Ala Pro Gln Pro Asp Asn Leu 
1               5                   10                  15      


Asn Lys Tyr Lys Cys Ile Ala Ile Val Arg Ala Ala Asn Leu Asp Ala 
            20                  25                  30          


Asp Ile Met Ser Asn Glu Ser Ser Asn Cys Val Met Cys Lys Gly Ile 
        35                  40                  45              


Lys Met Asn Lys Arg Lys Thr Ala Lys Gly Ala Ala Lys Thr Thr Glu 
    50                  55                  60                  


Leu Gly Arg Val Tyr Ala Gly Gln Ser Gly Asn Leu Leu Cys Thr Ala 
65                  70                  75                  80  


Cys Thr Lys Ser Thr Met Gly Pro Leu Val Asp Tyr Val Pro Ile Gly 
                85                  90                  95      


Arg Ile Arg Ala Lys Tyr Thr Ile Leu Arg Ala Val Lys Glu Tyr Asp 
            100                 105                 110         


Phe Leu Ser Leu Ala Tyr Asn Leu Ala Arg Thr Arg Val Ser Lys Lys 
        115                 120                 125             


Gly Gly Arg Gln Lys Met His Ser Leu Ser Glu Leu Val Ile Ala Ala 
    130                 135                 140                 


Glu Tyr Glu Ile Ala Trp Asn Ile Ile Lys Ser Ser Val Ile His Tyr 
145                 150                 155                 160 


His Gln Glu Thr Lys Glu Glu Ile Ser Gly Leu Arg Lys Lys Leu Gln 
                165                 170                 175     


Ala Glu His Ile His Lys Asn Lys Glu Ala Arg Ile Arg Arg Glu Met 
            180                 185                 190         


His Gln Ile Ser Arg Arg Ile Lys Arg Leu Lys Trp Lys Trp His Met 
        195                 200                 205             


Ile Pro Asn Ser Glu Leu His Asn Phe Leu Phe Lys Gln Gln Asp Pro 
    210                 215                 220                 


Ser Phe Val Ala Val Ala Leu Leu His Thr Leu Gly Arg Asp Ile Gly 
225                 230                 235                 240 


Met Ile Asn Lys Pro Lys Gly Ser Ala Lys Arg Glu Phe Ile Pro Glu 
                245                 250                 255     


Tyr Gly Phe Gln Ile Tyr Tyr Lys Trp Met Asn Pro Lys Leu Asn Asp 
            260                 265                 270         


Ile Asn Lys Gln Lys Tyr Arg Lys Met Pro Lys Arg Ser Leu Ile Pro 
        275                 280                 285             


Tyr Lys Asn Leu Asn Val Phe Gly Asp Arg Glu Leu Ile Glu Asn Ala 
    290                 295                 300                 


Met His Lys Leu Leu Lys Leu Tyr Asp Glu Asn Leu Glu Val Lys Gly 
305                 310                 315                 320 


Ser Lys Phe Phe Lys Thr Arg Val Val Ala Ile Ser Ser Lys Glu Ser 
                325                 330                 335     


Glu Lys Leu Lys Arg Asp Leu Leu Trp Lys Gly Glu Leu Ala Lys Ile 
            340                 345                 350         


Lys Lys Asp Phe Asn Ala Asp Lys Asn Lys Met Gln Glu Leu Phe Lys 
        355                 360                 365             


Glu Val Lys Glu Pro Lys Lys Ala Asn Ala Leu Met Lys Gln Ser Arg 
    370                 375                 380                 


Asn Met Gly Phe Leu Leu Gln Asn Ile Ser Tyr Gly Ala Leu Gly Leu 
385                 390                 395                 400 


Leu Ala Asn Arg Met Tyr Glu Ala Ser Ala Lys Gln Ser Lys Gly Asp 
                405                 410                 415     


Ala Thr Lys Gln Pro Ser Ile Val Ile Pro Leu Glu Met Glu Phe Gly 
            420                 425                 430         


Asn Ala Phe Pro Lys Leu Leu Leu Arg Ser Gly Lys Phe Ala Met Asn 
        435                 440                 445             


Val Ser Ser Pro Trp Leu Thr Ile Arg Lys Pro Lys Phe Val Ile Lys 
    450                 455                 460                 


Gly Asn Lys Ile Lys Asn Ile Thr Lys Leu Met Lys Asp Glu Lys Ala 
465                 470                 475                 480 


Lys Leu Lys Arg Leu Glu Thr Ser Tyr His Arg Ala Thr His Phe Arg 
                485                 490                 495     


Pro Thr Leu Arg Gly Ser Ile Asp Trp Asp Ser Pro Tyr Phe Ser Ser 
            500                 505                 510         


Pro Lys Gln Pro Asn Thr His Arg Arg Ser Pro Asp Arg Leu Ser Ala 
        515                 520                 525             


Asp Ile Thr Glu Tyr Arg Gly Arg Leu Lys Ser Val Glu Ala Glu Leu 
    530                 535                 540                 


Arg Glu Gly Gln Arg Ala Met Ala Lys Lys Leu Asp Ser Val Asp Met 
545                 550                 555                 560 


Thr Ala Ser Asn Leu Gln Thr Ser Asn Phe Gln Leu Glu Lys Gly Glu 
                565                 570                 575     


Asp Pro Arg Leu Thr Glu Ile Asp Glu Lys Gly Arg Ser Ile Arg Asn 
            580                 585                 590         


Cys Ile Ser Ser Trp Lys Lys Phe Met Glu Asp Leu Met Lys Ala Gln 
        595                 600                 605             


Glu Ala Asn Pro Val Ile Lys Ile Lys Ile Ala Leu Lys Asp Glu Ser 
    610                 615                 620                 


Ser Val Leu Ser Glu Asp Ser Met 
625                 630         


<210> 82
<211> 625
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Lys Phe His Pro Glu Asn Leu Asn Lys Ser Tyr Cys Leu Ala Ile Val 
1               5                   10                  15      


Arg Ala Ala Asn Leu Asp Ala Asp Ile Gln Gly His Ile Asn Cys Ile 
            20                  25                  30          


Gly Ile Lys Ser Asn Lys Ser Asp Arg Asn Tyr Glu Asn Lys Leu Glu 
        35                  40                  45              


Ser Leu Gln Asn Val Glu Leu Leu Cys Lys Ala Cys Thr Lys Ser Thr 
    50                  55                  60                  


Tyr Lys Pro Asn Ile Asn Ser Val Pro Val Gly Glu Lys Lys Ala Lys 
65                  70                  75                  80  


Tyr Ser Ile Leu Ser Glu Ile Lys Lys Tyr Asp Phe Asn Ser Leu Val 
                85                  90                  95      


Tyr Asn Leu Lys Lys Tyr Arg Lys Gly Lys Ser Arg Gly His Gln Lys 
            100                 105                 110         


Leu Asn Glu Leu Arg Glu Leu Val Ile Thr Ser Glu Tyr Lys Lys Ala 
        115                 120                 125             


Leu Asp Val Ile Asn Lys Ser Val Asn His Tyr Leu Val Asn Ile Lys 
    130                 135                 140                 


Asn Lys Met Ser Lys Leu Lys Lys Ile Leu Gln Asn Glu His Ile His 
145                 150                 155                 160 


Val Gly Thr Leu Ala Arg Ile Arg Arg Glu Arg Asn Arg Ile Ser Arg 
                165                 170                 175     


Lys Leu Asp His Tyr Arg Lys Lys Trp Lys Phe Val Pro Asn Lys Ile 
            180                 185                 190         


Leu Lys Asn Tyr Val Phe Lys Asn Gln Ser Pro Asp Phe Val Ser Val 
        195                 200                 205             


Ala Leu Leu His Lys Leu Gly Arg Asp Ile Gly Leu Ile Thr Lys Thr 
    210                 215                 220                 


Ala Ile Leu Gln Lys Ser Phe Pro Glu Tyr Ser Leu Gln Leu Tyr Tyr 
225                 230                 235                 240 


Lys Tyr Asp Thr Pro Lys Leu Asn Tyr Leu Lys Lys Ser Lys Phe Lys 
                245                 250                 255     


Ser Leu Pro Lys Arg Ile Leu Ile Ser Tyr Lys Tyr Pro Lys Phe Asp 
            260                 265                 270         


Ile Asn Ser Asn Tyr Ile Glu Glu Ser Ile Asp Lys Leu Leu Lys Leu 
        275                 280                 285             


Tyr Glu Glu Ser Pro Ile Tyr Lys Asn Asn Ser Lys Ile Ile Glu Phe 
    290                 295                 300                 


Phe Lys Lys Ser Glu Asp Asn Leu Ile Lys Ser Glu Asn Asp Ser Leu 
305                 310                 315                 320 


Lys Arg Gly Ile Met Lys Glu Phe Glu Lys Val Thr Lys Asn Phe Ser 
                325                 330                 335     


Ser Lys Lys Lys Lys Leu Lys Glu Glu Leu Lys Leu Lys Asn Glu Asp 
            340                 345                 350         


Lys Asn Ser Lys Met Leu Ala Lys Val Ser Arg Pro Ile Gly Phe Leu 
        355                 360                 365             


Lys Ala Tyr Leu Ser Tyr Met Leu Phe Asn Ile Ile Ser Asn Arg Ile 
    370                 375                 380                 


Phe Glu Phe Ser Arg Lys Ser Ser Gly Arg Ile Pro Gln Leu Pro Ser 
385                 390                 395                 400 


Cys Ile Ile Asn Leu Gly Asn Gln Phe Glu Asn Phe Lys Asn Glu Leu 
                405                 410                 415     


Gln Asp Ser Asn Ile Gly Ser Lys Lys Asn Tyr Lys Tyr Phe Cys Asn 
            420                 425                 430         


Leu Leu Leu Lys Ser Ser Gly Phe Asn Ile Ser Tyr Glu Glu Glu His 
        435                 440                 445             


Leu Ser Ile Lys Thr Pro Asn Phe Phe Ile Asn Gly Arg Lys Leu Lys 
    450                 455                 460                 


Glu Ile Thr Ser Glu Lys Lys Lys Ile Arg Lys Glu Asn Glu Gln Leu 
465                 470                 475                 480 


Ile Lys Gln Trp Lys Lys Leu Thr Phe Phe Lys Pro Ser Asn Leu Asn 
                485                 490                 495     


Gly Lys Lys Thr Ser Asp Lys Ile Arg Phe Lys Ser Pro Asn Asn Pro 
            500                 505                 510         


Asp Ile Glu Arg Lys Ser Glu Asp Asn Ile Val Glu Asn Ile Ala Lys 
        515                 520                 525             


Val Lys Tyr Lys Leu Glu Asp Leu Leu Ser Glu Gln Arg Lys Glu Phe 
    530                 535                 540                 


Asn Lys Leu Ala Lys Lys His Asp Gly Val Asp Val Glu Ala Gln Cys 
545                 550                 555                 560 


Leu Gln Thr Lys Ser Phe Trp Ile Asp Ser Asn Ser Pro Ile Lys Lys 
                565                 570                 575     


Ser Leu Glu Lys Lys Asn Glu Lys Val Ser Val Lys Lys Lys Met Lys 
            580                 585                 590         


Ala Ile Arg Ser Cys Ile Ser Ala Trp Lys Trp Phe Met Ala Asp Leu 
        595                 600                 605             


Ile Glu Ala Gln Lys Glu Thr Pro Met Ile Lys Leu Lys Leu Ala Leu 
    610                 615                 620                 


Met 
625 


<210> 83
<211> 517
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Thr Thr Leu Val Pro Ser His Leu Ala Gly Ile Glu Val Met Asp Glu 
1               5                   10                  15      


Thr Thr Ser Arg Asn Glu Asp Met Ile Gln Lys Glu Thr Ser Arg Ser 
            20                  25                  30          


Asn Glu Asp Glu Asn Tyr Leu Gly Val Lys Asn Lys Cys Gly Ile Asn 
        35                  40                  45              


Val His Lys Ser Gly Arg Gly Ser Ser Lys His Glu Pro Asn Met Pro 
    50                  55                  60                  


Pro Glu Lys Ser Gly Glu Gly Gln Met Pro Lys Gln Asp Ser Thr Glu 
65                  70                  75                  80  


Met Gln Gln Arg Phe Asp Glu Ser Val Thr Gly Glu Thr Gln Val Ser 
                85                  90                  95      


Ala Gly Ala Thr Ala Ser Ile Lys Thr Asp Ala Arg Ala Asn Ser Gly 
            100                 105                 110         


Pro Arg Val Gly Thr Ala Arg Ala Leu Ile Val Lys Ala Ser Asn Leu 
        115                 120                 125             


Asp Arg Asp Ile Lys Leu Gly Cys Lys Pro Cys Glu Tyr Ile Arg Ser 
    130                 135                 140                 


Glu Leu Pro Met Gly Lys Lys Asn Gly Cys Asn His Cys Glu Lys Ser 
145                 150                 155                 160 


Ser Asp Ile Ala Ser Val Pro Lys Val Glu Ser Gly Phe Arg Lys Ala 
                165                 170                 175     


Lys Tyr Glu Leu Val Arg Arg Phe Glu Ser Phe Ala Ala Asp Ser Ile 
            180                 185                 190         


Ser Arg His Leu Gly Lys Glu Gln Ala Arg Thr Arg Gly Lys Arg Gly 
        195                 200                 205             


Lys Lys Asp Lys Lys Glu Gln Met Gly Lys Val Asn Leu Asp Glu Ile 
    210                 215                 220                 


Ala Ile Leu Lys Asn Glu Ser Leu Ile Glu Tyr Thr Glu Asn Gln Ile 
225                 230                 235                 240 


Leu Asp Ala Arg Ser Asn Arg Ile Lys Glu Trp Leu Arg Ser Leu Arg 
                245                 250                 255     


Leu Arg Leu Arg Thr Arg Asn Lys Gly Leu Lys Lys Ser Lys Ser Ile 
            260                 265                 270         


Arg Arg Gln Leu Ile Thr Leu Arg Arg Asp Tyr Arg Lys Trp Ile Lys 
        275                 280                 285             


Pro Asn Pro Tyr Arg Pro Asp Glu Asp Pro Asn Glu Asn Ser Leu Arg 
    290                 295                 300                 


Leu His Thr Lys Leu Gly Val Asp Ile Gly Val Gln Gly Gly Asp Asn 
305                 310                 315                 320 


Lys Arg Met Asn Ser Asp Asp Tyr Glu Thr Ser Phe Ser Ile Thr Trp 
                325                 330                 335     


Arg Asp Thr Ala Thr Arg Lys Ile Cys Phe Thr Lys Pro Lys Gly Leu 
            340                 345                 350         


Leu Pro Arg His Met Lys Phe Lys Leu Arg Gly Tyr Pro Glu Leu Ile 
        355                 360                 365             


Leu Tyr Asn Glu Glu Leu Arg Ile Gln Asp Ser Gln Lys Phe Pro Leu 
    370                 375                 380                 


Val Asp Trp Glu Arg Ile Pro Ile Phe Lys Leu Arg Gly Val Ser Leu 
385                 390                 395                 400 


Gly Lys Lys Lys Val Lys Ala Leu Asn Arg Ile Thr Glu Ala Pro Arg 
                405                 410                 415     


Leu Val Val Ala Lys Arg Ile Gln Val Asn Ile Glu Ser Lys Lys Lys 
            420                 425                 430         


Lys Val Leu Thr Arg Tyr Val Tyr Asn Asp Lys Ser Ile Asn Gly Arg 
        435                 440                 445             


Leu Val Lys Ala Glu Asp Ser Asn Lys Asp Pro Leu Leu Glu Phe Lys 
    450                 455                 460                 


Lys Gln Ala Glu Glu Ile Asn Ser Asp Ala Lys Tyr Tyr Glu Asn Gln 
465                 470                 475                 480 


Glu Ile Ala Lys Asn Tyr Leu Trp Gly Cys Glu Gly Leu His Lys Asn 
                485                 490                 495     


Leu Leu Glu Glu Gln Thr Lys Asn Pro Tyr Leu Ala Phe Lys Tyr Gly 
            500                 505                 510         


Phe Leu Asn Ile Val 
        515         


<210> 84
<211> 410
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Leu Asp Phe Lys Arg Thr Cys Ser Gln Glu Leu Val Leu Leu Pro Glu 
1               5                   10                  15      


Ile Glu Gly Leu Lys Leu Ser Gly Thr Gln Gly Val Thr Ser Leu Ala 
            20                  25                  30          


Lys Lys Leu Ile Asn Lys Ala Ala Asn Val Asp Arg Asp Glu Ser Tyr 
        35                  40                  45              


Gly Cys His His Cys Ile His Thr Arg Thr Ser Leu Ser Lys Pro Val 
    50                  55                  60                  


Lys Lys Asp Cys Asn Ser Cys Asn Gln Ser Thr Asn His Pro Ala Val 
65                  70                  75                  80  


Pro Ile Thr Leu Lys Gly Tyr Lys Ile Ala Phe Tyr Glu Leu Trp His 
                85                  90                  95      


Arg Phe Thr Ser Trp Ala Val Asp Ser Ile Ser Lys Ala Leu His Arg 
            100                 105                 110         


Asn Lys Val Met Gly Lys Val Asn Leu Asp Glu Tyr Ala Val Val Asp 
        115                 120                 125             


Asn Ser His Ile Val Cys Tyr Ala Val Arg Lys Cys Tyr Glu Lys Arg 
    130                 135                 140                 


Gln Arg Ser Val Arg Leu His Lys Arg Ala Tyr Arg Cys Arg Ala Lys 
145                 150                 155                 160 


His Tyr Asn Lys Ser Gln Pro Lys Val Gly Arg Ile Tyr Lys Lys Ser 
                165                 170                 175     


Lys Arg Arg Asn Ala Arg Asn Leu Lys Lys Glu Ala Lys Arg Tyr Phe 
            180                 185                 190         


Gln Pro Asn Glu Ile Thr Asn Gly Ser Ser Asp Ala Leu Phe Tyr Lys 
        195                 200                 205             


Ile Gly Val Asp Leu Gly Ile Ala Lys Gly Thr Pro Glu Thr Glu Val 
    210                 215                 220                 


Lys Val Asp Val Ser Ile Cys Phe Gln Val Tyr Tyr Gly Asp Ala Arg 
225                 230                 235                 240 


Arg Val Leu Arg Val Arg Lys Met Asp Glu Leu Gln Ser Phe His Leu 
                245                 250                 255     


Asp Tyr Thr Gly Lys Leu Lys Leu Lys Gly Ile Gly Asn Lys Asp Thr 
            260                 265                 270         


Phe Thr Ile Ala Lys Arg Asn Glu Ser Leu Lys Trp Gly Ser Thr Lys 
        275                 280                 285             


Tyr Glu Val Ser Arg Ala His Lys Lys Phe Lys Pro Phe Gly Lys Lys 
    290                 295                 300                 


Gly Ser Val Lys Arg Lys Cys Asn Asp Tyr Phe Arg Ser Ile Ala Ser 
305                 310                 315                 320 


Trp Ser Cys Glu Ala Ala Ser Gln Arg Ala Gln Ser Asn Leu Lys Asn 
                325                 330                 335     


Ala Phe Pro Tyr Gln Lys Ala Leu Val Lys Cys Tyr Lys Asn Leu Asp 
            340                 345                 350         


Tyr Lys Gly Val Lys Lys Asn Asp Met Trp Tyr Arg Leu Cys Ser Asn 
        355                 360                 365             


Arg Ile Phe Arg Tyr Ser Arg Ile Ala Glu Asp Ile Ala Gln Tyr Gln 
    370                 375                 380                 


Ser Asp Lys Gly Lys Ala Lys Phe Glu Phe Val Ile Leu Ala Gln Ser 
385                 390                 395                 400 


Val Ala Glu Tyr Asp Ile Ser Ala Ile Met 
                405                 410 


<210> 85
<211> 602
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Val Phe Leu Thr Asp Asp Lys Arg Lys Thr Ala Leu Arg Lys Ile Arg 
1               5                   10                  15      


Ser Ala Phe Arg Lys Thr Ala Glu Ile Ala Leu Val Arg Ala Gln Glu 
            20                  25                  30          


Ala Asp Ser Leu Asp Arg Gln Ala Lys Lys Leu Thr Ile Glu Thr Val 
        35                  40                  45              


Ser Phe Gly Ala Pro Gly Ala Lys Asn Ala Phe Ile Gly Ser Leu Gln 
    50                  55                  60                  


Gly Tyr Asn Trp Asn Ser His Arg Ala Asn Val Pro Ser Ser Gly Ser 
65                  70                  75                  80  


Ala Lys Asp Val Phe Arg Ile Thr Glu Leu Gly Leu Gly Ile Pro Gln 
                85                  90                  95      


Ser Ala His Glu Ala Ser Ile Gly Lys Ser Phe Glu Leu Val Gly Asn 
            100                 105                 110         


Val Val Arg Tyr Thr Ala Asn Leu Leu Ser Lys Gly Tyr Lys Lys Gly 
        115                 120                 125             


Ala Val Asn Lys Gly Ala Lys Gln Gln Arg Glu Ile Lys Gly Lys Glu 
    130                 135                 140                 


Gln Leu Ser Phe Asp Leu Ile Ser Asn Gly Pro Ile Ser Gly Asp Lys 
145                 150                 155                 160 


Leu Ile Asn Gly Gln Lys Asp Ala Leu Ala Trp Trp Leu Ile Asp Lys 
                165                 170                 175     


Met Gly Phe His Ile Gly Leu Ala Met Glu Pro Leu Ser Ser Pro Asn 
            180                 185                 190         


Thr Tyr Gly Ile Thr Leu Gln Ala Phe Trp Lys Arg His Thr Ala Pro 
        195                 200                 205             


Arg Arg Tyr Ser Arg Gly Val Ile Arg Gln Trp Gln Leu Pro Phe Gly 
    210                 215                 220                 


Arg Gln Leu Ala Pro Leu Ile His Asn Phe Phe Arg Lys Lys Gly Ala 
225                 230                 235                 240 


Ser Ile Pro Ile Val Leu Thr Asn Ala Ser Lys Lys Leu Ala Gly Lys 
                245                 250                 255     


Gly Val Leu Leu Glu Gln Thr Ala Leu Val Asp Pro Lys Lys Trp Trp 
            260                 265                 270         


Gln Val Lys Glu Gln Val Thr Gly Pro Leu Ser Asn Ile Trp Glu Arg 
        275                 280                 285             


Ser Val Pro Leu Val Leu Tyr Thr Ala Thr Phe Thr His Lys His Gly 
    290                 295                 300                 


Ala Ala His Lys Arg Pro Leu Thr Leu Lys Val Ile Arg Ile Ser Ser 
305                 310                 315                 320 


Gly Ser Val Phe Leu Leu Pro Leu Ser Lys Val Thr Pro Gly Lys Leu 
                325                 330                 335     


Val Arg Ala Trp Met Pro Asp Ile Asn Ile Leu Arg Asp Gly Arg Pro 
            340                 345                 350         


Asp Glu Ala Ala Tyr Lys Gly Pro Asp Leu Ile Arg Ala Arg Glu Arg 
        355                 360                 365             


Ser Phe Pro Leu Ala Tyr Thr Cys Val Thr Gln Ile Ala Asp Glu Trp 
    370                 375                 380                 


Gln Lys Arg Ala Leu Glu Ser Asn Arg Asp Ser Ile Thr Pro Leu Glu 
385                 390                 395                 400 


Ala Lys Leu Val Thr Gly Ser Asp Leu Leu Gln Ile His Ser Thr Val 
                405                 410                 415     


Gln Gln Ala Val Glu Gln Gly Ile Gly Gly Arg Ile Ser Ser Pro Ile 
            420                 425                 430         


Gln Glu Leu Leu Ala Lys Asp Ala Leu Gln Leu Val Leu Gln Gln Leu 
        435                 440                 445             


Phe Met Thr Val Asp Leu Leu Arg Ile Gln Trp Gln Leu Lys Gln Glu 
    450                 455                 460                 


Val Ala Asp Gly Asn Thr Ser Glu Lys Ala Val Gly Trp Ala Ile Arg 
465                 470                 475                 480 


Ile Ser Asn Ile His Lys Asp Ala Tyr Lys Thr Ala Ile Glu Pro Cys 
                485                 490                 495     


Thr Ser Ala Leu Lys Gln Ala Trp Asn Pro Leu Ser Gly Phe Glu Glu 
            500                 505                 510         


Arg Thr Phe Gln Leu Asp Ala Ser Ile Val Arg Lys Arg Ser Thr Ala 
        515                 520                 525             


Lys Thr Pro Asp Asp Glu Leu Val Ile Val Leu Arg Gln Gln Ala Ala 
    530                 535                 540                 


Glu Met Thr Val Ala Val Thr Gln Ser Val Ser Lys Glu Leu Met Glu 
545                 550                 555                 560 


Leu Ala Val Arg His Ser Ala Thr Leu His Leu Leu Val Gly Glu Val 
                565                 570                 575     


Ala Ser Lys Gln Leu Ser Arg Ser Ala Asp Lys Asp Arg Gly Ala Met 
            580                 585                 590         


Asp His Trp Lys Leu Leu Ser Gln Ser Met 
        595                 600         


<210> 86
<211> 494
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 86
Glu Asp Leu Leu Gln Lys Ala Leu Asn Thr Ala Thr Asn Val Ala Ala 
1               5                   10                  15      


Ile Glu Arg His Ser Cys Ile Ser Cys Leu Phe Thr Glu Ser Glu Ile 
            20                  25                  30          


Asp Val Lys Tyr Lys Thr Pro Asp Lys Ile Gly Gln Asn Thr Ala Gly 
        35                  40                  45              


Cys Gln Ser Cys Thr Phe Arg Val Gly Tyr Ser Gly Asn Ser His Thr 
    50                  55                  60                  


Leu Pro Met Gly Asn Arg Ile Ala Leu Asp Lys Leu Arg Glu Thr Ile 
65                  70                  75                  80  


Gln Arg Tyr Ala Trp His Ser Leu Leu Phe Asn Val Pro Pro Ala Pro 
                85                  90                  95      


Thr Ser Lys Arg Val Arg Ala Ile Ser Glu Leu Arg Val Ala Ala Gly 
            100                 105                 110         


Arg Glu Arg Leu Phe Thr Val Ile Thr Phe Val Gln Thr Asn Ile Leu 
        115                 120                 125             


Ser Lys Leu Gln Lys Arg Tyr Ala Ala Asn Trp Thr Pro Lys Ser Gln 
    130                 135                 140                 


Glu Arg Leu Ser Arg Leu Arg Glu Glu Gly Gln His Ile Leu Ser Leu 
145                 150                 155                 160 


Leu Glu Ser Gly Ser Trp Gln Gln Lys Glu Val Val Arg Glu Asp Gln 
                165                 170                 175     


Asp Leu Ile Val Cys Ser Ala Leu Thr Lys Pro Gly Leu Ser Ile Gly 
            180                 185                 190         


Ala Phe Cys Arg Pro Lys Tyr Leu Lys Pro Ala Lys His Ala Leu Val 
        195                 200                 205             


Leu Arg Leu Ile Phe Val Glu Gln Trp Pro Gly Gln Ile Trp Gly Gln 
    210                 215                 220                 


Ser Lys Arg Thr Arg Arg Met Arg Arg Arg Lys Asp Val Glu Arg Val 
225                 230                 235                 240 


Tyr Asp Ile Ser Val Gln Ala Trp Ala Leu Lys Gly Lys Glu Thr Arg 
                245                 250                 255     


Ile Ser Glu Cys Ile Asp Thr Met Arg Arg His Gln Gln Ala Tyr Ile 
            260                 265                 270         


Gly Val Leu Pro Phe Leu Ile Leu Ser Gly Ser Thr Val Arg Gly Lys 
        275                 280                 285             


Gly Asp Cys Pro Ile Leu Lys Glu Ile Thr Arg Met Arg Tyr Cys Pro 
    290                 295                 300                 


Asn Asn Glu Gly Leu Ile Pro Leu Gly Ile Phe Tyr Arg Gly Ser Ala 
305                 310                 315                 320 


Asn Lys Leu Leu Arg Val Val Lys Gly Ser Ser Phe Thr Leu Pro Met 
                325                 330                 335     


Trp Gln Asn Ile Glu Thr Leu Pro His Pro Glu Pro Phe Ser Pro Glu 
            340                 345                 350         


Gly Trp Thr Ala Thr Gly Ala Leu Tyr Glu Lys Asn Leu Ala Tyr Trp 
        355                 360                 365             


Ser Ala Leu Asn Glu Ala Val Asp Trp Tyr Thr Gly Gln Ile Leu Ser 
    370                 375                 380                 


Ser Gly Leu Gln Tyr Pro Asn Gln Asn Glu Phe Leu Ala Arg Leu Gln 
385                 390                 395                 400 


Asn Val Ile Asp Ser Ile Pro Arg Lys Trp Phe Arg Pro Gln Gly Leu 
                405                 410                 415     


Lys Asn Leu Lys Pro Asn Gly Gln Glu Asp Ile Val Pro Asn Glu Phe 
            420                 425                 430         


Val Ile Pro Gln Asn Ala Ile Arg Ala His His Val Ile Glu Trp Tyr 
        435                 440                 445             


His Lys Thr Asn Asp Leu Val Ala Lys Thr Leu Leu Gly Trp Gly Ser 
    450                 455                 460                 


Gln Thr Thr Leu Asn Gln Thr Arg Pro Gln Gly Asp Leu Arg Phe Thr 
465                 470                 475                 480 


Tyr Thr Arg Tyr Tyr Phe Arg Glu Lys Glu Val Pro Glu Val 
                485                 490                 


<210> 87
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 87
Val Pro Lys Lys Lys Leu Met Arg Glu Leu Ala Lys Lys Ala Val Phe 
1               5                   10                  15      


Glu Ala Ile Phe Asn Asp Pro Ile Pro Gly Ser Phe Gly Cys Lys Arg 
            20                  25                  30          


Cys Thr Leu Ile Asp Gly Ala Arg Val Thr Asp Ala Ile Glu Lys Lys 
        35                  40                  45              


Gln Gly Ala Lys Arg Cys Ala Gly Cys Glu Pro Cys Thr Phe His Thr 
    50                  55                  60                  


Leu Tyr Asp Ser Val Lys His Ala Leu Pro Ala Ala Thr Gly Cys Asp 
65                  70                  75                  80  


Arg Thr Ala Ile Asp Thr Gly Leu Trp Glu Ile Leu Thr Ala Leu Arg 
                85                  90                  95      


Ser Tyr Asn Trp Met Ser Phe Arg Arg Asn Ala Val Ser Asp Ala Ser 
            100                 105                 110         


Gln Lys Gln Val Trp Ser Ile Glu Glu Leu Ala Ile Trp Ala Asp Lys 
        115                 120                 125             


Glu Arg Ala Leu Arg Val Ile Leu Ser Ala Leu Thr His Thr Ile Gly 
    130                 135                 140                 


Lys Leu Lys Asn Gly Phe Ser Arg Asp Gly Val Trp Lys Gly Gly Lys 
145                 150                 155                 160 


Gln Leu Tyr Glu Asn Leu Ala Gln Lys Asp Leu Ala Lys Gly Leu Phe 
                165                 170                 175     


Ala Asn Gly Glu Ile Phe Gly Lys Glu Leu Val Glu Ala Asp His Asp 
            180                 185                 190         


Met Leu Ala Trp Thr Ile Val Pro Asn His Gln Phe His Ile Gly Leu 
        195                 200                 205             


Ile Arg Gly Asn Trp Lys Pro Ala Ala Val Glu Ala Ser Thr Ala Phe 
    210                 215                 220                 


Asp Ala Arg Trp Leu Thr Asn Gly Ala Pro Leu Arg Asp Thr Arg Thr 
225                 230                 235                 240 


His Gly His Arg Gly Arg Arg Phe Asn Arg Thr Glu Lys Leu Thr Val 
                245                 250                 255     


Leu Cys Ile Lys Arg Asp Gly Gly Val Ser Glu Glu Phe Arg Gln Glu 
            260                 265                 270         


Arg Asp Tyr Glu Leu Ser Val Met Leu Leu Gln Pro Lys Asn Lys Leu 
        275                 280                 285             


Lys Pro Glu Pro Lys Gly Glu Leu Asn Ser Phe Glu Asp Leu His Asp 
    290                 295                 300                 


His Trp Trp Phe Leu Lys Gly Asp Glu Ala Thr Ala Leu Val Gly Leu 
305                 310                 315                 320 


Thr Ser Asp Pro Thr Val Gly Asp Phe Ile Gln Leu Gly Leu Tyr Ile 
                325                 330                 335     


Arg Asn Pro Ile Lys Ala His Gly Glu Thr Lys Arg Arg Leu Leu Ile 
            340                 345                 350         


Cys Phe Glu Pro Pro Ile Lys Leu Pro Leu Arg Arg Ala Phe Pro Ser 
        355                 360                 365             


Glu Ala Phe Lys Thr Trp Glu Pro Thr Ile Asn Val Phe Arg Asn Gly 
    370                 375                 380                 


Arg Arg Asp Thr Glu Ala Tyr Tyr Asp Ile Asp Arg Ala Arg Val Phe 
385                 390                 395                 400 


Glu Phe Pro Glu Thr Arg Val Ser Leu Glu His Leu Ser Lys Gln Trp 
                405                 410                 415     


Glu Val Leu Arg Leu Glu Pro Asp Arg Glu Asn Thr Asp Pro Tyr Glu 
            420                 425                 430         


Ala Gln Gln Asn Glu Gly Ala Glu Leu Gln Val Tyr Ser Leu Leu Gln 
        435                 440                 445             


Glu Ala Ala Gln Lys Met Ala Pro Lys Val Val Ile Asp Pro Phe Gly 
    450                 455                 460                 


Gln Phe Pro Leu Glu Leu Phe Ser Thr Phe Val Ala Gln Leu Phe Asn 
465                 470                 475                 480 


Ala Pro Leu Ser Asp Thr Lys Ala Lys Ile Gly Lys Pro Leu Asp Ser 
                485                 490                 495     


Gly Phe Val Val Glu Ser His Leu His Leu Leu Glu Glu Asp Phe Ala 
            500                 505                 510         


Tyr Arg Asp Phe Val Arg Val Thr Phe Met Gly Thr Glu Pro Thr Phe 
        515                 520                 525             


Arg Val Ile His Tyr Ser Asn Gly Glu Gly Tyr Trp Lys Lys Thr Val 
    530                 535                 540                 


Leu Lys Gly Lys Asn Asn Ile Arg Thr Ala Leu Ile Pro Glu Gly Ala 
545                 550                 555                 560 


Lys Ala Ala Val Asp Ala Tyr Lys Asn Lys Arg Cys Pro Leu Thr Leu 
                565                 570                 575     


Glu Ala Ala Ile Leu Asn Glu Glu Lys Asp Arg Arg Leu Val Leu Gly 
            580                 585                 590         


Asn Lys Ala Leu Ser Leu Leu Ala Gln Thr Ala Arg Gly Asn Leu Thr 
        595                 600                 605             


Ile Leu Glu Ala Leu Ala Ala Glu Val Leu Arg Pro Leu Ser Gly Thr 
    610                 615                 620                 


Glu Gly Val Val His Leu His Ala Cys Val Thr Arg His Ser Thr Leu 
625                 630                 635                 640 


Thr Glu Ser Thr Glu Thr Asp Asn Met 
                645                 


<210> 88
<211> 414
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
Val Glu Lys Leu Phe Ser Glu Arg Leu Lys Arg Ala Met Trp Leu Lys 
1               5                   10                  15      


Asn Glu Ala Gly Arg Ala Pro Pro Ala Glu Thr Leu Thr Leu Lys His 
            20                  25                  30          


Lys Arg Val Ser Gly Gly His Glu Lys Val Lys Glu Glu Leu Gln Arg 
        35                  40                  45              


Val Leu Arg Ser Leu Ser Gly Thr Asn Gln Ala Ala Trp Asn Leu Gly 
    50                  55                  60                  


Leu Ser Gly Gly Arg Glu Pro Lys Ser Ser Asp Ala Leu Lys Gly Glu 
65                  70                  75                  80  


Lys Ser Arg Val Val Leu Glu Thr Val Val Phe His Ser Gly His Asn 
                85                  90                  95      


Arg Val Leu Tyr Asp Val Ile Glu Arg Glu Asp Gln Val His Gln Arg 
            100                 105                 110         


Ser Ser Ile Met His Met Arg Arg Lys Gly Ser Asn Leu Leu Arg Leu 
        115                 120                 125             


Trp Gly Arg Ser Gly Lys Val Arg Arg Lys Met Arg Glu Glu Val Ala 
    130                 135                 140                 


Glu Ile Lys Pro Val Trp His Lys Asp Ser Arg Trp Leu Ala Ile Val 
145                 150                 155                 160 


Glu Glu Gly Arg Gln Ser Val Val Gly Ile Ser Ser Ala Gly Leu Ala 
                165                 170                 175     


Val Phe Ala Val Gln Glu Ser Gln Cys Thr Thr Ala Glu Pro Lys Pro 
            180                 185                 190         


Leu Glu Tyr Val Val Ser Ile Trp Phe Arg Gly Ser Lys Ala Leu Asn 
        195                 200                 205             


Pro Gln Asp Arg Tyr Leu Glu Phe Lys Lys Leu Lys Thr Thr Glu Ala 
    210                 215                 220                 


Leu Arg Gly Gln Gln Tyr Asp Pro Ile Pro Phe Ser Leu Lys Arg Gly 
225                 230                 235                 240 


Ala Gly Cys Ser Leu Ala Ile Arg Gly Glu Gly Ile Lys Phe Gly Ser 
                245                 250                 255     


Arg Gly Pro Ile Lys Gln Phe Phe Gly Ser Asp Arg Ser Arg Pro Ser 
            260                 265                 270         


His Ala Asp Tyr Asp Gly Lys Arg Arg Leu Ser Leu Phe Ser Lys Tyr 
        275                 280                 285             


Ala Gly Asp Leu Ala Asp Leu Thr Glu Glu Gln Trp Asn Arg Thr Val 
    290                 295                 300                 


Ser Ala Phe Ala Glu Asp Glu Val Arg Arg Ala Thr Leu Ala Asn Ile 
305                 310                 315                 320 


Gln Asp Phe Leu Ser Ile Ser His Glu Lys Tyr Ala Glu Arg Leu Lys 
                325                 330                 335     


Lys Arg Ile Glu Ser Ile Glu Glu Pro Val Ser Ala Ser Lys Leu Glu 
            340                 345                 350         


Ala Tyr Leu Ser Ala Ile Phe Glu Thr Phe Val Gln Gln Arg Glu Ala 
        355                 360                 365             


Leu Ala Ser Asn Phe Leu Met Arg Leu Val Glu Ser Val Ala Leu Leu 
    370                 375                 380                 


Ile Ser Leu Glu Glu Lys Ser Pro Arg Val Glu Phe Arg Val Ala Arg 
385                 390                 395                 400 


Tyr Leu Ala Glu Ser Lys Glu Gly Phe Asn Arg Lys Ala Met 
                405                 410                 


<210> 89
<211> 413
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
Val Val Ile Thr Gln Ser Glu Leu Tyr Lys Glu Arg Leu Leu Arg Val 
1               5                   10                  15      


Met Glu Ile Lys Asn Asp Arg Gly Arg Lys Glu Pro Arg Glu Ser Gln 
            20                  25                  30          


Gly Leu Val Leu Arg Phe Thr Gln Val Thr Gly Gly Gln Glu Lys Val 
        35                  40                  45              


Lys Gln Lys Leu Trp Leu Ile Phe Glu Gly Phe Ser Gly Thr Asn Gln 
    50                  55                  60                  


Ala Ser Trp Asn Phe Gly Gln Pro Ala Gly Gly Arg Lys Pro Asn Ser 
65                  70                  75                  80  


Gly Asp Ala Leu Lys Gly Pro Lys Ser Arg Val Thr Tyr Glu Thr Val 
                85                  90                  95      


Val Phe His Phe Gly Leu Arg Leu Leu Ser Ala Val Ile Glu Arg His 
            100                 105                 110         


Asn Leu Lys Gln Gln Arg Gln Thr Met Ala Tyr Met Lys Arg Arg Ala 
        115                 120                 125             


Ala Ala Arg Lys Lys Trp Ala Arg Ser Gly Lys Lys Cys Ser Arg Met 
    130                 135                 140                 


Arg Asn Glu Val Glu Lys Ile Lys Pro Lys Trp His Lys Asp Pro Arg 
145                 150                 155                 160 


Trp Phe Asp Ile Val Lys Glu Gly Glu Pro Ser Ile Val Gly Ile Ser 
                165                 170                 175     


Ser Ala Gly Phe Ala Ile Tyr Ile Val Glu Glu Pro Asn Phe Pro Arg 
            180                 185                 190         


Gln Asp Pro Leu Glu Ile Glu Tyr Ala Ile Ser Ile Trp Phe Arg Arg 
        195                 200                 205             


Asp Arg Ser Gln Tyr Leu Thr Phe Lys Lys Ile Gln Lys Ala Glu Lys 
    210                 215                 220                 


Leu Lys Glu Leu Gln Tyr Asn Pro Ile Pro Phe Arg Leu Lys Gln Glu 
225                 230                 235                 240 


Lys Thr Ser Leu Val Phe Glu Ser Gly Asp Ile Lys Phe Gly Ser Arg 
                245                 250                 255     


Gly Ser Ile Glu His Phe Arg Asp Glu Ala Arg Gly Lys Pro Pro Lys 
            260                 265                 270         


Ala Asp Met Asp Asn Asn Arg Arg Leu Thr Met Phe Ser Val Phe Ser 
        275                 280                 285             


Gly Asn Leu Thr Asn Leu Thr Glu Glu Gln Tyr Ala Arg Pro Val Ser 
    290                 295                 300                 


Gly Leu Leu Ala Pro Asp Glu Lys Arg Met Pro Thr Leu Leu Lys Lys 
305                 310                 315                 320 


Leu Gln Asp Phe Phe Thr Pro Ile His Glu Lys Tyr Gly Glu Arg Ile 
                325                 330                 335     


Lys Gln Arg Leu Ala Asn Ser Glu Ala Ser Lys Arg Pro Phe Lys Lys 
            340                 345                 350         


Leu Glu Glu Tyr Leu Pro Ala Ile Tyr Leu Glu Phe Arg Ala Arg Arg 
        355                 360                 365             


Glu Gly Leu Ala Ser Asn Trp Val Leu Val Leu Ile Asn Ser Val Arg 
    370                 375                 380                 


Thr Leu Val Arg Ile Lys Ser Glu Asp Pro Tyr Ile Glu Phe Lys Val 
385                 390                 395                 400 


Ser Gln Tyr Leu Leu Glu Lys Glu Asp Asn Lys Ala Leu 
                405                 410             


<210> 90
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
Lys Gln Asp Ala Leu Phe Glu Glu Arg Leu Lys Lys Ala Ile Phe Ile 
1               5                   10                  15      


Lys Arg Gln Ala Asp Pro Leu Gln Arg Glu Glu Leu Ser Leu Leu Pro 
            20                  25                  30          


Pro Asn Arg Lys Ile Val Thr Gly Gly His Glu Ser Ala Lys Asp Thr 
        35                  40                  45              


Leu Lys Gln Ile Leu Arg Ala Ile Asn Gly Thr Asn Gln Ala Ser Trp 
    50                  55                  60                  


Asn Pro Gly Thr Pro Ser Gly Lys Arg Asp Ser Lys Ser Ala Asp Ala 
65                  70                  75                  80  


Leu Ala Gly Pro Lys Ser Arg Val Lys Leu Glu Thr Val Val Phe His 
                85                  90                  95      


Val Gly His Arg Leu Leu Lys Lys Val Val Glu Tyr Gln Gly His Gln 
            100                 105                 110         


Lys Gln Gln His Gly Leu Lys Ala Phe Met Arg Thr Cys Ala Ala Met 
        115                 120                 125             


Arg Lys Lys Trp Lys Arg Ser Gly Lys Val Val Gly Glu Leu Arg Glu 
    130                 135                 140                 


Gln Leu Ala Asn Ile Gln Pro Lys Trp His Tyr Asp Ser Arg Pro Leu 
145                 150                 155                 160 


Asn Leu Cys Phe Glu Gly Lys Pro Ser Val Val Gly Leu Arg Ser Ala 
                165                 170                 175     


Gly Ile Ala Leu Tyr Thr Ile Gln Lys Ser Val Val Pro Val Lys Glu 
            180                 185                 190         


Pro Lys Pro Ile Glu Tyr Ala Val Ser Ile Trp Phe Arg Gly Pro Lys 
        195                 200                 205             


Ala Met Asp Arg Glu Asp Arg Cys Leu Glu Phe Lys Lys Leu Lys Ile 
    210                 215                 220                 


Ala Thr Glu Leu Arg Lys Leu Gln Phe Glu Pro Ile Val Ser Thr Leu 
225                 230                 235                 240 


Thr Gln Gly Ile Lys Gly Phe Ser Leu Tyr Ile Gln Gly Asn Ser Val 
                245                 250                 255     


Lys Phe Gly Ser Arg Gly Pro Ile Lys Tyr Phe Ser Asn Glu Ser Val 
            260                 265                 270         


Arg Gln Arg Pro Pro Lys Ala Asp Pro Asp Gly Asn Lys Arg Leu Ala 
        275                 280                 285             


Leu Phe Ser Lys Phe Ser Gly Asp Leu Ser Asp Leu Thr Glu Glu Gln 
    290                 295                 300                 


Trp Asn Arg Pro Ile Leu Ala Phe Glu Gly Ile Ile Arg Arg Ala Thr 
305                 310                 315                 320 


Leu Gly Asn Ile Gln Asp Tyr Leu Thr Val Gly His Glu Gln Phe Ala 
                325                 330                 335     


Ile Ser Leu Glu Gln Leu Leu Ser Glu Lys Glu Ser Val Leu Gln Met 
            340                 345                 350         


Ser Ile Glu Gln Gln Arg Leu Lys Lys Asn Leu Gly Lys Lys Ala Glu 
        355                 360                 365             


Asn Glu Trp Val Glu Ser Phe Gly Ala Glu Gln Ala Arg Lys Lys Ala 
    370                 375                 380                 


Gln Gly Ile Arg Glu Tyr Ile Ser Gly Phe Phe Gln Glu Tyr Cys Ser 
385                 390                 395                 400 


Gln Arg Glu Gln Trp Ala Glu Asn Trp Val Gln Gln Leu Asn Lys Ser 
                405                 410                 415     


Val Arg Leu Phe Leu Thr Ile Gln Asp Ser Thr Pro Phe Ile Glu Phe 
            420                 425                 430         


Arg Val Ala Arg Tyr Leu Pro Lys Gly Glu Lys Lys Lys Gly Lys Ala 
        435                 440                 445             


Met 
    


<210> 91
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
Ala Asn His Ala Glu Arg His Lys Arg Leu Arg Lys Glu Ala Asn Arg 
1               5                   10                  15      


Ala Ala Asn Arg Asn Arg Pro Leu Val Ala Asp Cys Asp Thr Gly Asp 
            20                  25                  30          


Pro Leu Val Gly Ile Cys Arg Leu Leu Arg Arg Gly Asp Lys Met Gln 
        35                  40                  45              


Pro Asn Lys Thr Gly Cys Arg Ser Cys Glu Gln Val Glu Pro Glu Leu 
    50                  55                  60                  


Arg Asp Ala Ile Leu Val Ser Gly Pro Gly Arg Leu Asp Asn Tyr Lys 
65                  70                  75                  80  


Tyr Glu Leu Phe Gln Arg Gly Arg Ala Met Ala Val His Arg Leu Leu 
                85                  90                  95      


Lys Arg Val Pro Lys Leu Asn Arg Pro Lys Lys Ala Ala Gly Asn Asp 
            100                 105                 110         


Glu Lys Lys Ala Glu Asn Lys Lys Ser Glu Ile Gln Lys Glu Lys Gln 
        115                 120                 125             


Lys Gln Arg Arg Met Met Pro Ala Val Ser Met Lys Gln Val Ser Val 
    130                 135                 140                 


Ala Asp Phe Lys His Val Ile Glu Asn Thr Val Arg His Leu Phe Gly 
145                 150                 155                 160 


Asp Arg Arg Asp Arg Glu Ile Ala Glu Cys Ala Ala Leu Arg Ala Ala 
                165                 170                 175     


Ser Lys Tyr Phe Leu Lys Ser Arg Arg Val Arg Pro Arg Lys Leu Pro 
            180                 185                 190         


Lys Leu Ala Asn Pro Asp His Gly Lys Glu Leu Lys Gly Leu Arg Leu 
        195                 200                 205             


Arg Glu Lys Arg Ala Lys Leu Lys Lys Glu Lys Glu Lys Gln Ala Glu 
    210                 215                 220                 


Leu Ala Arg Ser Asn Gln Lys Gly Ala Val Leu His Val Ala Thr Leu 
225                 230                 235                 240 


Lys Lys Asp Ala Pro Pro Met Pro Tyr Glu Lys Thr Gln Gly Arg Asn 
                245                 250                 255     


Asp Tyr Thr Thr Phe Val Ile Ser Ala Ala Ile Lys Val Gly Ala Thr 
            260                 265                 270         


Arg Gly Thr Lys Pro Leu Leu Thr Pro Gln Pro Arg Glu Trp Gln Cys 
        275                 280                 285             


Ser Leu Tyr Trp Arg Asp Gly Gln Arg Trp Ile Arg Gly Gly Leu Leu 
    290                 295                 300                 


Gly Leu Gln Ala Gly Ile Val Leu Gly Pro Lys Leu Asn Arg Glu Leu 
305                 310                 315                 320 


Leu Glu Ala Val Leu Gln Arg Pro Ile Glu Cys Arg Met Ser Gly Cys 
                325                 330                 335     


Gly Asn Pro Leu Gln Val Arg Gly Ala Ala Val Asp Phe Phe Met Thr 
            340                 345                 350         


Thr Asn Pro Phe Tyr Val Ser Gly Ala Ala Tyr Ala Gln Lys Lys Phe 
        355                 360                 365             


Lys Pro Phe Gly Thr Lys Arg Ala Ser Glu Asp Gly Ala Ala Ala Lys 
    370                 375                 380                 


Ala Arg Glu Lys Leu Met Thr Gln Leu Ala Lys Val Leu Asp Lys Val 
385                 390                 395                 400 


Val Thr Gln Ala Ala His Ser Pro Leu Asp Gly Ile Trp Glu Thr Arg 
                405                 410                 415     


Pro Glu Ala Lys Leu Arg Ala Met Ile Met Ala Leu Glu His Glu Trp 
            420                 425                 430         


Ile Phe Leu Arg Pro Gly Pro Cys His Asn Ala Ala Glu Glu Val Ile 
        435                 440                 445             


Lys Cys Asp Cys Thr Gly Gly His Ala Ile Leu Trp Ala Leu Ile Asp 
    450                 455                 460                 


Glu Ala Arg Gly Ala Leu Glu His Lys Glu Phe Tyr Ala Val Thr Arg 
465                 470                 475                 480 


Ala His Thr His Asp Cys Glu Lys Gln Lys Leu Gly Gly Arg Leu Ala 
                485                 490                 495     


Gly Phe Leu Asp Leu Leu Ile Ala Gln Asp Val Pro Leu Asp Asp Ala 
            500                 505                 510         


Pro Ala Ala Arg Lys Ile Lys Thr Leu Leu Glu Ala Thr Pro Pro Ala 
        515                 520                 525             


Pro Cys Tyr Lys Ala Ala Thr Ser Ile Ala Thr Cys Asp Cys Glu Gly 
    530                 535                 540                 


Lys Phe Asp Lys Leu Trp Ala Ile Ile Asp Ala Thr Arg Ala Gly His 
545                 550                 555                 560 


Gly Thr Glu Asp Leu Trp Ala Arg Thr Leu Ala Tyr Pro Gln Asn Val 
                565                 570                 575     


Asn Cys Lys Cys Lys Ala Gly Lys Asp Leu Thr His Arg Leu Ala Asp 
            580                 585                 590         


Phe Leu Gly Leu Leu Ile Lys Arg Asp Gly Pro Phe Arg Glu Arg Pro 
        595                 600                 605             


Pro His Lys Val Thr Gly Asp Arg Lys Leu Val Phe Ser Gly Asp Lys 
    610                 615                 620                 


Lys Cys Lys Gly His Gln Tyr Val Ile Leu Ala Lys Ala His Asn Glu 
625                 630                 635                 640 


Glu Val Val Arg Ala Trp Ile Ser Arg Trp Gly Leu Lys Ser Arg Thr 
                645                 650                 655     


Asn Lys Ala Gly Tyr Ala Ala Thr Glu Leu Asn Leu Leu Leu Asn Trp 
            660                 665                 670         


Leu Ser Ile Cys Arg Arg Arg Trp Met Asp Met Leu Thr Val Gln Arg 
        675                 680                 685             


Asp Thr Pro Tyr Ile Arg Met Lys Thr Gly Arg Leu Val Val Asp Asp 
    690                 695                 700                 


Lys Lys Glu Arg Lys Ala Met 
705                 710     


<210> 92
<211> 574
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
Ala Lys Gln Arg Glu Ala Leu Arg Val Ala Leu Glu Arg Gly Ile Val 
1               5                   10                  15      


Arg Ala Ser Asn Arg Thr Tyr Thr Leu Val Thr Asn Cys Thr Lys Gly 
            20                  25                  30          


Gly Pro Leu Pro Glu Gln Cys Arg Met Ile Glu Arg Gly Lys Ala Arg 
        35                  40                  45              


Ala Met Lys Trp Glu Pro Lys Leu Val Gly Cys Gly Ser Cys Ala Ala 
    50                  55                  60                  


Ala Thr Val Asp Leu Pro Ala Ile Glu Glu Tyr Ala Gln Pro Gly Arg 
65                  70                  75                  80  


Leu Asp Val Ala Lys Tyr Lys Leu Thr Thr Gln Ile Leu Ala Met Ala 
                85                  90                  95      


Thr Arg Arg Met Met Val Arg Ala Ala Lys Leu Ser Arg Arg Lys Gly 
            100                 105                 110         


Gln Trp Pro Ala Lys Val Gln Glu Glu Lys Glu Glu Pro Pro Glu Pro 
        115                 120                 125             


Lys Lys Met Leu Lys Ala Val Glu Met Arg Pro Val Ala Ile Val Asp 
    130                 135                 140                 


Phe Asn Arg Val Ile Gln Thr Thr Ile Glu His Leu Trp Ala Glu Arg 
145                 150                 155                 160 


Ala Asn Ala Asp Glu Ala Glu Leu Lys Ala Leu Lys Ala Ala Ala Ala 
                165                 170                 175     


Tyr Phe Gly Pro Ser Leu Lys Ile Arg Ala Arg Gly Pro Pro Lys Ala 
            180                 185                 190         


Ala Ile Gly Arg Glu Leu Lys Lys Ala His Arg Lys Lys Ala Tyr Ala 
        195                 200                 205             


Glu Arg Lys Lys Ala Arg Arg Lys Arg Ala Glu Leu Ala Arg Ser Gln 
    210                 215                 220                 


Ala Arg Gly Ala Ala Ala His Ala Ala Ile Arg Glu Arg Asp Ile Pro 
225                 230                 235                 240 


Pro Met Ala Tyr Glu Arg Thr Gln Gly Arg Asn Asp Val Thr Thr Ile 
                245                 250                 255     


Pro Ile Ala Ala Ala Ile Lys Ile Ala Ala Thr Arg Gly Ala Arg Pro 
            260                 265                 270         


Leu Pro Ala Pro Lys Pro Met Lys Trp Gln Cys Ser Leu Tyr Trp Asn 
        275                 280                 285             


Glu Gly Gln Arg Trp Ile Arg Gly Gly Met Leu Thr Ala Gln Ala Tyr 
    290                 295                 300                 


Ala His Ala Ala Asn Ile His Arg Pro Met Arg Cys Glu Met Trp Gly 
305                 310                 315                 320 


Val Gly Asn Pro Leu Lys Val Arg Ala Phe Glu Gly Arg Val Ala Asp 
                325                 330                 335     


Pro Asp Gly Ala Lys Gly Arg Lys Ala Glu Phe Arg Leu Gln Thr Asn 
            340                 345                 350         


Ala Phe Tyr Val Ser Gly Ala Ala Tyr Arg Asn Lys Lys Phe Lys Pro 
        355                 360                 365             


Phe Gly Thr Asp Arg Gly Gly Ile Gly Ser Ala Arg Lys Lys Arg Glu 
    370                 375                 380                 


Arg Leu Met Ala Gln Leu Ala Lys Ile Leu Asp Lys Val Val Ser Gln 
385                 390                 395                 400 


Ala Ala His Ser Pro Leu Asp Asp Ile Trp His Thr Arg Pro Ala Gln 
                405                 410                 415     


Lys Leu Arg Ala Met Ile Lys Gln Leu Glu His Glu Trp Met Phe Leu 
            420                 425                 430         


Arg Pro Gln Ala Pro Thr Val Glu Gly Thr Lys Pro Asp Val Asp Val 
        435                 440                 445             


Ala Gly Asn Met Gln Arg Gln Ile Lys Ala Leu Met Ala Pro Asp Leu 
    450                 455                 460                 


Pro Pro Ile Glu Lys Gly Ser Pro Ala Lys Arg Phe Thr Gly Asp Lys 
465                 470                 475                 480 


Arg Lys Lys Gly Glu Arg Ala Val Arg Val Ala Glu Ala His Ser Asp 
                485                 490                 495     


Glu Val Val Thr Ala Trp Ile Ser Arg Trp Gly Ile Gln Thr Arg Arg 
            500                 505                 510         


Asn Glu Gly Ser Tyr Ala Ala Gln Glu Leu Glu Leu Leu Leu Asn Trp 
        515                 520                 525             


Leu Gln Ile Cys Arg Arg Arg Trp Leu Asp Met Thr Ala Ala Gln Arg 
    530                 535                 540                 


Val Ser Pro Tyr Ile Arg Met Lys Ser Gly Arg Met Ile Thr Asp Ala 
545                 550                 555                 560 


Ala Asp Glu Gly Val Ala Pro Ile Pro Leu Val Glu Asn Met 
                565                 570                 


<210> 93
<211> 743
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 93
Lys Ser Ile Ser Gly Arg Ser Ile Lys His Met Ala Cys Leu Lys Asp 
1               5                   10                  15      


Met Leu Lys Ser Glu Ile Thr Glu Ile Glu Glu Lys Gln Lys Lys Glu 
            20                  25                  30          


Ser Leu Arg Lys Trp Asp Tyr Tyr Ser Lys Phe Ser Asp Glu Ile Leu 
        35                  40                  45              


Phe Arg Arg Asn Leu Asn Val Ser Ala Asn His Asp Ala Asn Ala Cys 
    50                  55                  60                  


Tyr Gly Cys Asn Pro Cys Ala Phe Leu Lys Glu Val Tyr Gly Phe Arg 
65                  70                  75                  80  


Ile Glu Arg Arg Asn Asn Glu Arg Ile Ile Ser Tyr Arg Arg Gly Leu 
                85                  90                  95      


Ala Gly Cys Lys Ser Cys Val Gln Ser Thr Gly Tyr Pro Pro Ile Glu 
            100                 105                 110         


Phe Val Arg Arg Lys Phe Gly Ala Asp Lys Ala Met Glu Ile Val Arg 
        115                 120                 125             


Glu Val Leu His Arg Arg Asn Trp Gly Ala Leu Ala Arg Asn Ile Gly 
    130                 135                 140                 


Arg Glu Lys Glu Ala Asp Pro Ile Leu Gly Glu Leu Asn Glu Leu Leu 
145                 150                 155                 160 


Leu Val Asp Ala Arg Pro Tyr Phe Gly Asn Lys Ser Ala Ala Asn Glu 
                165                 170                 175     


Thr Asn Leu Ala Phe Asn Val Ile Thr Arg Ala Ala Lys Lys Phe Arg 
            180                 185                 190         


Asp Glu Gly Met Tyr Asp Ile His Lys Gln Leu Asp Ile His Ser Glu 
        195                 200                 205             


Glu Gly Lys Val Pro Lys Gly Arg Lys Ser Arg Leu Ile Arg Ile Glu 
    210                 215                 220                 


Arg Lys His Lys Ala Ile His Gly Leu Asp Pro Gly Glu Thr Trp Arg 
225                 230                 235                 240 


Tyr Pro His Cys Gly Lys Gly Glu Lys Tyr Gly Val Trp Leu Asn Arg 
                245                 250                 255     


Ser Arg Leu Ile His Ile Lys Gly Asn Glu Tyr Arg Cys Leu Thr Ala 
            260                 265                 270         


Phe Gly Thr Thr Gly Arg Arg Met Ser Leu Asp Val Ala Cys Ser Val 
        275                 280                 285             


Leu Gly His Pro Leu Val Lys Lys Lys Arg Lys Lys Gly Lys Lys Thr 
    290                 295                 300                 


Val Asp Gly Thr Glu Leu Trp Gln Ile Lys Lys Ala Thr Glu Thr Leu 
305                 310                 315                 320 


Pro Glu Asp Pro Ile Asp Cys Thr Phe Tyr Leu Tyr Ala Ala Lys Pro 
                325                 330                 335     


Thr Lys Asp Pro Phe Ile Leu Lys Val Gly Ser Leu Lys Ala Pro Arg 
            340                 345                 350         


Trp Lys Lys Leu His Lys Asp Phe Phe Glu Tyr Ser Asp Thr Glu Lys 
        355                 360                 365             


Thr Gln Gly Gln Glu Lys Gly Lys Arg Val Val Arg Arg Gly Lys Val 
    370                 375                 380                 


Pro Arg Ile Leu Ser Leu Arg Pro Asp Ala Lys Phe Lys Val Ser Ile 
385                 390                 395                 400 


Trp Asp Asp Pro Tyr Asn Gly Lys Asn Lys Glu Gly Thr Leu Leu Arg 
                405                 410                 415     


Met Glu Leu Ser Gly Leu Asp Gly Ala Lys Lys Pro Leu Ile Leu Lys 
            420                 425                 430         


Arg Tyr Gly Glu Pro Asn Thr Lys Pro Lys Asn Phe Val Phe Trp Arg 
        435                 440                 445             


Pro His Ile Thr Pro His Pro Leu Thr Phe Thr Pro Lys His Asp Phe 
    450                 455                 460                 


Gly Asp Pro Asn Lys Lys Thr Lys Arg Arg Arg Val Phe Asn Arg Glu 
465                 470                 475                 480 


Tyr Tyr Gly His Leu Asn Asp Leu Ala Lys Met Glu Pro Asn Ala Lys 
                485                 490                 495     


Phe Phe Glu Asp Arg Glu Val Ser Asn Lys Lys Asn Pro Lys Ala Lys 
            500                 505                 510         


Asn Ile Arg Ile Gln Ala Lys Glu Ser Leu Pro Asn Ile Val Ala Lys 
        515                 520                 525             


Asn Gly Arg Trp Ala Ala Phe Asp Pro Asn Asp Ser Leu Trp Lys Leu 
    530                 535                 540                 


Tyr Leu His Trp Arg Gly Arg Arg Lys Thr Ile Lys Gly Gly Ile Ser 
545                 550                 555                 560 


Gln Glu Phe Gln Glu Phe Lys Glu Arg Leu Asp Leu Tyr Lys Lys His 
                565                 570                 575     


Glu Asp Glu Ser Glu Trp Lys Glu Lys Glu Lys Leu Trp Glu Asn His 
            580                 585                 590         


Glu Lys Glu Trp Lys Lys Thr Leu Glu Ile His Gly Ser Ile Ala Glu 
        595                 600                 605             


Val Ser Gln Arg Cys Val Met Gln Ser Met Met Gly Pro Leu Asp Gly 
    610                 615                 620                 


Leu Val Gln Lys Lys Asp Tyr Val His Ile Gly Gln Ser Ser Leu Lys 
625                 630                 635                 640 


Ala Ala Asp Asp Ala Trp Thr Phe Ser Ala Asn Arg Tyr Lys Lys Ala 
                645                 650                 655     


Thr Gly Pro Lys Trp Gly Lys Ile Ser Val Ser Asn Leu Leu Tyr Asp 
            660                 665                 670         


Ala Asn Gln Ala Asn Ala Glu Leu Ile Ser Gln Ser Ile Ser Lys Tyr 
        675                 680                 685             


Leu Ser Lys Gln Lys Asp Asn Gln Gly Cys Glu Gly Arg Lys Met Lys 
    690                 695                 700                 


Phe Leu Ile Lys Ile Ile Glu Pro Leu Arg Glu Asn Phe Val Lys His 
705                 710                 715                 720 


Thr Arg Trp Leu His Glu Met Thr Gln Lys Asp Cys Glu Val Arg Ala 
                725                 730                 735     


Gln Phe Ser Arg Val Ser Met 
            740             


<210> 94
<211> 769
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
Phe Pro Ser Asp Val Gly Ala Asp Ala Leu Lys His Val Arg Met Leu 
1               5                   10                  15      


Gln Pro Arg Leu Thr Asp Glu Val Arg Lys Val Ala Leu Thr Arg Ala 
            20                  25                  30          


Pro Ser Asp Arg Pro Ala Leu Ala Arg Phe Ala Ala Val Ala Gln Asp 
        35                  40                  45              


Gly Leu Ala Phe Val Arg His Leu Asn Val Ser Ala Asn His Asp Ser 
    50                  55                  60                  


Asn Cys Thr Phe Pro Arg Asp Pro Arg Asp Pro Arg Arg Gly Pro Cys 
65                  70                  75                  80  


Glu Pro Asn Pro Cys Ala Phe Leu Arg Glu Val Trp Gly Phe Arg Ile 
                85                  90                  95      


Val Ala Arg Gly Asn Glu Arg Ala Leu Ser Tyr Arg Arg Gly Leu Ala 
            100                 105                 110         


Gly Cys Lys Ser Cys Val Gln Ser Thr Gly Phe Pro Ser Val Pro Phe 
        115                 120                 125             


His Arg Ile Gly Ala Asp Asp Cys Met Arg Lys Leu His Glu Ile Leu 
    130                 135                 140                 


Lys Ala Arg Asn Trp Arg Leu Leu Ala Arg Asn Ile Gly Arg Glu Arg 
145                 150                 155                 160 


Glu Ala Asp Pro Leu Leu Thr Glu Leu Ser Glu Tyr Leu Leu Val Asp 
                165                 170                 175     


Ala Arg Thr Tyr Pro Asp Gly Ala Ala Pro Asn Ser Gly Arg Leu Ala 
            180                 185                 190         


Glu Asn Val Ile Lys Arg Ala Ala Lys Lys Phe Arg Asp Glu Gly Met 
        195                 200                 205             


Arg Asp Ile His Ala Gln Leu Arg Val His Ser Arg Glu Gly Lys Val 
    210                 215                 220                 


Pro Lys Gly Arg Leu Gln Arg Leu Arg Arg Ile Glu Arg Lys His Arg 
225                 230                 235                 240 


Ala Ile His Ala Leu Asp Pro Gly Pro Ser Trp Glu Ala Glu Gly Ser 
                245                 250                 255     


Ala Arg Ala Glu Val Gln Gly Val Ala Val Tyr Arg Ser Gln Leu Leu 
            260                 265                 270         


Arg Val Gly His His Thr Gln Gln Ile Glu Pro Val Gly Ile Val Ala 
        275                 280                 285             


Arg Thr Leu Phe Gly Val Gly Arg Thr Asp Leu Asp Val Ala Val Ser 
    290                 295                 300                 


Val Leu Gly Ala Pro Leu Thr Lys Arg Lys Lys Gly Ser Lys Thr Leu 
305                 310                 315                 320 


Glu Ser Thr Glu Asp Phe Arg Ile Ala Lys Ala Arg Glu Thr Arg Ala 
                325                 330                 335     


Glu Asp Lys Ile Glu Val Ala Phe Val Leu Tyr Pro Thr Ala Ser Leu 
            340                 345                 350         


Leu Arg Asp Glu Ile Pro Lys Asp Ala Phe Pro Ala Met Arg Ile Asp 
        355                 360                 365             


Arg Phe Leu Leu Lys Val Gly Ser Val Gln Ala Asp Arg Glu Ile Leu 
    370                 375                 380                 


Leu Gln Asp Asp Tyr Tyr Arg Phe Gly Asp Ala Glu Val Lys Ala Gly 
385                 390                 395                 400 


Lys Asn Lys Gly Arg Thr Val Thr Arg Pro Val Lys Val Pro Arg Leu 
                405                 410                 415     


Gln Ala Leu Arg Pro Asp Ala Lys Phe Arg Val Asn Val Trp Ala Asp 
            420                 425                 430         


Pro Phe Gly Ala Gly Asp Ser Pro Gly Thr Leu Leu Arg Leu Glu Val 
        435                 440                 445             


Ser Gly Val Thr Arg Arg Ser Gln Pro Leu Arg Leu Leu Arg Tyr Gly 
    450                 455                 460                 


Gln Pro Ser Thr Gln Pro Ala Asn Phe Leu Cys Trp Arg Pro His Arg 
465                 470                 475                 480 


Val Pro Asp Pro Met Thr Phe Thr Pro Arg Gln Lys Phe Gly Glu Arg 
                485                 490                 495     


Arg Lys Asn Arg Arg Thr Arg Arg Pro Arg Val Phe Glu Arg Leu Tyr 
            500                 505                 510         


Gln Val His Ile Lys His Leu Ala His Leu Glu Pro Asn Arg Lys Trp 
        515                 520                 525             


Phe Glu Glu Ala Arg Val Ser Ala Gln Lys Trp Ala Lys Ala Arg Ala 
    530                 535                 540                 


Ile Arg Arg Lys Gly Ala Glu Asp Ile Pro Val Val Ala Pro Pro Ala 
545                 550                 555                 560 


Lys Arg Arg Trp Ala Ala Leu Gln Pro Asn Ala Glu Leu Trp Asp Leu 
                565                 570                 575     


Tyr Ala His Asp Arg Glu Ala Arg Lys Arg Phe Arg Gly Gly Arg Ala 
            580                 585                 590         


Ala Glu Gly Glu Glu Phe Lys Pro Arg Leu Asn Leu Tyr Leu Ala His 
        595                 600                 605             


Glu Pro Glu Ala Glu Trp Glu Ser Lys Arg Asp Arg Trp Glu Arg Tyr 
    610                 615                 620                 


Glu Lys Lys Trp Thr Ala Val Leu Glu Glu His Ser Arg Met Cys Ala 
625                 630                 635                 640 


Val Ala Asp Arg Thr Leu Pro Gln Phe Leu Ser Asp Pro Leu Gly Ala 
                645                 650                 655     


Arg Met Asp Asp Lys Asp Tyr Ala Phe Val Gly Lys Ser Ala Leu Ala 
            660                 665                 670         


Val Ala Glu Ala Phe Val Glu Glu Gly Thr Val Glu Arg Ala Gln Gly 
        675                 680                 685             


Asn Cys Ser Ile Thr Ala Lys Lys Lys Phe Ala Ser Asn Ala Ser Arg 
    690                 695                 700                 


Lys Arg Leu Ser Val Ala Asn Leu Leu Asp Val Ser Asp Lys Ala Asp 
705                 710                 715                 720 


Arg Ala Leu Val Phe Gln Ala Val Arg Gln Tyr Val Gln Arg Gln Ala 
                725                 730                 735     


Glu Asn Gly Gly Val Glu Gly Arg Arg Met Ala Phe Leu Arg Lys Leu 
            740                 745                 750         


Leu Ala Pro Leu Arg Gln Asn Phe Val Cys His Thr Arg Trp Leu His 
        755                 760                 765             


Met 
    


<210> 95
<211> 564
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 95
Ala Ala Arg Lys Lys Lys Arg Gly Lys Ile Gly Ile Thr Val Lys Ala 
1               5                   10                  15      


Lys Glu Lys Ser Pro Pro Ala Ala Gly Pro Phe Met Ala Arg Lys Leu 
            20                  25                  30          


Val Asn Val Ala Ala Asn Val Asp Gly Val Glu Val His Leu Cys Val 
        35                  40                  45              


Glu Cys Glu Ala Asp Ala His Gly Ser Ala Ser Ala Arg Leu Leu Gly 
    50                  55                  60                  


Gly Cys Arg Ser Cys Thr Gly Ser Ile Gly Ala Glu Gly Arg Leu Met 
65                  70                  75                  80  


Gly Ser Val Asp Val Asp Arg Glu Arg Val Ile Ala Glu Pro Val His 
                85                  90                  95      


Thr Glu Thr Glu Arg Leu Gly Pro Asp Val Lys Ala Phe Glu Ala Gly 
            100                 105                 110         


Thr Ala Glu Ser Lys Tyr Ala Ile Gln Arg Gly Leu Glu Tyr Trp Gly 
        115                 120                 125             


Val Asp Leu Ile Ser Arg Asn Arg Ala Arg Thr Val Arg Lys Met Glu 
    130                 135                 140                 


Glu Ala Asp Arg Pro Glu Ser Ser Thr Met Glu Lys Thr Ser Trp Asp 
145                 150                 155                 160 


Glu Ile Ala Ile Lys Thr Tyr Ser Gln Ala Tyr His Ala Ser Glu Asn 
                165                 170                 175     


His Leu Phe Trp Glu Arg Gln Arg Arg Val Arg Gln His Ala Leu Ala 
            180                 185                 190         


Leu Phe Arg Arg Ala Arg Glu Arg Asn Arg Gly Glu Ser Pro Leu Gln 
        195                 200                 205             


Ser Thr Gln Arg Pro Ala Pro Leu Val Leu Ala Ala Leu His Ala Glu 
    210                 215                 220                 


Ala Ala Ala Ile Ser Gly Arg Ala Arg Ala Glu Tyr Val Leu Arg Gly 
225                 230                 235                 240 


Pro Ser Ala Asn Val Arg Ala Ala Ala Ala Asp Ile Asp Ala Lys Pro 
                245                 250                 255     


Leu Gly His Tyr Lys Thr Pro Ser Pro Lys Val Ala Arg Gly Phe Pro 
            260                 265                 270         


Val Lys Arg Asp Leu Leu Arg Ala Arg His Arg Ile Val Gly Leu Ser 
        275                 280                 285             


Arg Ala Tyr Phe Lys Pro Ser Asp Val Val Arg Gly Thr Ser Asp Ala 
    290                 295                 300                 


Ile Ala His Val Ala Gly Arg Asn Ile Gly Val Ala Gly Gly Lys Pro 
305                 310                 315                 320 


Lys Glu Ile Glu Lys Thr Phe Thr Leu Pro Phe Val Ala Tyr Trp Glu 
                325                 330                 335     


Asp Val Asp Arg Val Val His Cys Ser Ser Phe Lys Ala Asp Gly Pro 
            340                 345                 350         


Trp Val Arg Asp Gln Arg Ile Lys Ile Arg Gly Val Ser Ser Ala Val 
        355                 360                 365             


Gly Thr Phe Ser Leu Tyr Gly Leu Asp Val Ala Trp Ser Lys Pro Thr 
    370                 375                 380                 


Ser Phe Tyr Ile Arg Cys Ser Asp Ile Arg Lys Lys Phe His Pro Lys 
385                 390                 395                 400 


Gly Phe Gly Pro Met Lys His Trp Arg Gln Trp Ala Lys Glu Leu Asp 
                405                 410                 415     


Arg Leu Thr Glu Gln Arg Ala Ser Cys Val Val Arg Ala Leu Gln Asp 
            420                 425                 430         


Asp Glu Glu Leu Leu Gln Thr Met Glu Arg Gly Gln Arg Tyr Tyr Asp 
        435                 440                 445             


Val Phe Ser Cys Ala Ala Thr His Ala Thr Arg Gly Glu Ala Asp Pro 
    450                 455                 460                 


Ser Gly Gly Cys Ser Arg Cys Glu Leu Val Ser Cys Gly Val Ala His 
465                 470                 475                 480 


Lys Val Thr Lys Lys Ala Lys Gly Asp Thr Gly Ile Glu Ala Val Ala 
                485                 490                 495     


Val Ala Gly Cys Ser Leu Cys Glu Ser Lys Leu Val Gly Pro Ser Lys 
            500                 505                 510         


Pro Arg Val His Arg Gln Met Ala Ala Leu Arg Gln Ser His Ala Leu 
        515                 520                 525             


Asn Tyr Leu Arg Arg Leu Gln Arg Glu Trp Glu Ala Leu Glu Ala Val 
    530                 535                 540                 


Gln Ala Pro Thr Pro Tyr Leu Arg Phe Lys Tyr Ala Arg His Leu Glu 
545                 550                 555                 560 


Val Arg Ser Met 
                


<210> 96
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 96
Ala Ala Lys Lys Lys Lys Gln Arg Gly Lys Ile Gly Ile Ser Val Lys 
1               5                   10                  15      


Pro Lys Glu Gly Ser Ala Pro Pro Ala Asp Gly Pro Phe Met Ala Arg 
            20                  25                  30          


Lys Leu Val Asn Val Ala Ala Asn Val Asp Gly Val Glu Val Asn Leu 
        35                  40                  45              


Cys Ile Glu Cys Glu Ala Asp Ala His Gly Ser Ala Pro Ala Arg Leu 
    50                  55                  60                  


Leu Gly Gly Cys Lys Ser Cys Thr Gly Ser Ile Gly Ala Glu Gly Arg 
65                  70                  75                  80  


Leu Met Gly Ser Val Asp Val Asp Arg Ala Asp Ala Ile Ala Lys Pro 
                85                  90                  95      


Val Asn Thr Glu Thr Glu Lys Leu Gly Pro Asp Val Gln Ala Phe Glu 
            100                 105                 110         


Ala Gly Thr Ala Glu Thr Lys Tyr Ala Leu Gln Arg Gly Leu Glu Tyr 
        115                 120                 125             


Trp Gly Val Asp Leu Ile Ser Arg Asn Arg Ser Arg Thr Val Arg Arg 
    130                 135                 140                 


Thr Glu Glu Gly Gln Pro Glu Ser Ala Thr Met Glu Lys Thr Ser Trp 
145                 150                 155                 160 


Asp Glu Ile Ala Ile Lys Ser Tyr Thr Arg Ala Tyr His Ala Ser Glu 
                165                 170                 175     


Asn His Leu Phe Trp Glu Arg Gln Arg Arg Val Arg Gln His Ala Leu 
            180                 185                 190         


Ala Leu Phe Lys Arg Ala Lys Glu Arg Asn Arg Gly Asp Ser Thr Leu 
        195                 200                 205             


Pro Arg Glu Pro Gly His Gly Leu Val Ala Ile Ala Ala Leu Ala Cys 
    210                 215                 220                 


Glu Ala Tyr Ala Val Gly Gly Arg Asn Leu Ala Glu Thr Val Val Arg 
225                 230                 235                 240 


Gly Pro Thr Phe Gly Thr Ala Arg Ala Val Arg Asp Val Glu Ile Ala 
                245                 250                 255     


Ser Leu Gly Arg Tyr Lys Thr Pro Ser Pro Lys Val Ala His Gly Ser 
            260                 265                 270         


Pro Val Lys Arg Asp Phe Leu Arg Ala Arg His Arg Ile Val Gly Leu 
        275                 280                 285             


Ala Arg Ala Tyr Tyr Arg Pro Ser Asp Val Val Arg Gly Thr Ser Asp 
    290                 295                 300                 


Ala Ile Ala His Val Ala Gly Arg Asn Ile Gly Val Ala Gly Gly Lys 
305                 310                 315                 320 


Pro Arg Ala Val Glu Ala Val Phe Thr Leu Pro Phe Val Ala Tyr Trp 
                325                 330                 335     


Glu Asp Val Asp Arg Val Val His Cys Ser Ser Phe Gln Val Ser Ala 
            340                 345                 350         


Pro Trp Asn Arg Asp Gln Arg Met Lys Ile Ala Gly Val Thr Thr Ala 
        355                 360                 365             


Ala Gly Thr Phe Ser Leu His Gly Gly Glu Leu Lys Trp Ala Lys Pro 
    370                 375                 380                 


Thr Ser Phe Tyr Ile Arg Cys Ser Asp Thr Arg Arg Lys Phe Arg Pro 
385                 390                 395                 400 


Lys Gly Phe Gly Pro Met Lys Arg Trp Arg Gln Trp Ala Lys Asp Leu 
                405                 410                 415     


Asp Arg Leu Val Glu Gln Arg Ala Ser Cys Val Val Arg Ala Leu Gln 
            420                 425                 430         


Asp Asp Ala Ala Leu Leu Glu Thr Met Glu Arg Gly Gln Arg Tyr Tyr 
        435                 440                 445             


Asp Val Phe Ala Cys Ala Val Thr His Ala Thr Arg Gly Glu Ala Asp 
    450                 455                 460                 


Arg Leu Ala Gly Cys Ser Arg Cys Ala Leu Thr Pro Cys Gln Glu Ala 
465                 470                 475                 480 


His Arg Val Thr Thr Lys Pro Arg Gly Asp Ala Gly Val Glu Gln Val 
                485                 490                 495     


Gln Thr Ser Asp Cys Ser Leu Cys Glu Gly Lys Leu Val Gly Pro Ser 
            500                 505                 510         


Lys Pro Arg Leu His Arg Thr Leu Thr Leu Leu Arg Gln Glu His Gly 
        515                 520                 525             


Leu Asn Tyr Leu Arg Arg Leu Gln Arg Glu Trp Glu Ser Leu Glu Ala 
    530                 535                 540                 


Val Gln Val Pro Thr Pro Tyr Leu Arg Phe Lys Tyr Ala Arg His Leu 
545                 550                 555                 560 


Glu Val Arg Ser Met 
                565 


<210> 97
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 97
Thr Asp Ser Gln Ser Glu Ser Val Pro Glu Val Val Tyr Ala Leu Thr 
1               5                   10                  15      


Gly Gly Glu Val Pro Gly Arg Val Pro Pro Asp Gly Gly Ser Ala Glu 
            20                  25                  30          


Gly Ala Arg Asn Ala Pro Thr Gly Leu Arg Lys Gln Arg Gly Lys Ile 
        35                  40                  45              


Lys Ile Ser Ala Lys Pro Ser Lys Pro Gly Ser Pro Ala Ser Ser Leu 
    50                  55                  60                  


Ala Arg Thr Leu Val Asn Glu Ala Ala Asn Val Asp Gly Val Gln Ser 
65                  70                  75                  80  


Ser Gly Cys Ala Thr Cys Arg Met Arg Ala Asn Gly Ser Ala Pro Arg 
                85                  90                  95      


Ala Leu Pro Ile Gly Cys Val Ala Cys Ala Ser Ser Ile Gly Arg Ala 
            100                 105                 110         


Pro Gln Glu Glu Thr Val Cys Ala Leu Pro Thr Thr Gln Gly Pro Asp 
        115                 120                 125             


Val Arg Leu Leu Glu Gly Gly His Ala Leu Arg Lys Tyr Asp Ile Gln 
    130                 135                 140                 


Arg Ala Leu Glu Tyr Trp Gly Val Asp Leu Ile Gly Arg Asn Leu Asp 
145                 150                 155                 160 


Arg Gln Ala Gly Arg Gly Met Glu Pro Ala Glu Gly Ala Thr Ala Thr 
                165                 170                 175     


Met Lys Arg Val Ser Met Asp Glu Leu Ala Val Leu Asp Phe Gly Lys 
            180                 185                 190         


Ser Tyr Tyr Ala Ser Glu Gln His Leu Phe Ala Ala Arg Gln Arg Arg 
        195                 200                 205             


Val Arg Gln His Ala Lys Ala Leu Lys Ile Arg Ala Lys His Ala Asn 
    210                 215                 220                 


Arg Ser Gly Ser Val Lys Arg Ala Leu Asp Arg Ser Arg Lys Gln Val 
225                 230                 235                 240 


Thr Ala Leu Ala Arg Glu Phe Phe Lys Pro Ser Asp Val Val Arg Gly 
                245                 250                 255     


Asp Ser Asp Ala Leu Ala His Val Val Gly Arg Asn Leu Gly Val Ser 
            260                 265                 270         


Arg His Pro Ala Arg Glu Ile Pro Gln Thr Phe Thr Leu Pro Leu Cys 
        275                 280                 285             


Ala Tyr Trp Glu Asp Val Asp Arg Val Ile Ser Cys Ser Ser Leu Leu 
    290                 295                 300                 


Ala Gly Glu Pro Phe Ala Arg Asp Gln Glu Ile Arg Ile Glu Gly Val 
305                 310                 315                 320 


Ser Ser Ala Leu Gly Ser Leu Arg Leu Tyr Arg Gly Ala Ile Glu Trp 
                325                 330                 335     


His Lys Pro Thr Ser Leu Tyr Ile Arg Cys Ser Asp Thr Arg Arg Lys 
            340                 345                 350         


Phe Arg Pro Arg Gly Gly Leu Lys Lys Arg Trp Arg Gln Trp Ala Lys 
        355                 360                 365             


Asp Leu Asp Arg Leu Val Glu Gln Arg Ala Cys Cys Ile Val Arg Ser 
    370                 375                 380                 


Leu Gln Ala Asp Val Glu Leu Leu Gln Thr Met Glu Arg Ala Gln Arg 
385                 390                 395                 400 


Phe Tyr Asp Val His Asp Cys Ala Ala Thr His Val Gly Pro Val Ala 
                405                 410                 415     


Val Arg Cys Ser Pro Cys Ala Gly Lys Gln Phe Asp Trp Asp Arg Tyr 
            420                 425                 430         


Arg Leu Leu Ala Ala Leu Arg Gln Glu His Ala Leu Asn Tyr Leu Arg 
        435                 440                 445             


Arg Leu Gln Arg Glu Trp Glu Ser Leu Glu Ala Gln Gln Val Lys Met 
    450                 455                 460                 


Pro Tyr Leu Arg Phe Lys Tyr Ala Arg Lys Leu Glu Val Ser Gly Pro 
465                 470                 475                 480 


Leu Ile Gly Leu Glu Val Arg Arg Glu Pro Ser Met Gly Thr Ala Ile 
                485                 490                 495     


Ala Glu Met 
            


<210> 98
<211> 358
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
Ala Gly Thr Ala Gly Arg Arg His Gly Ser Leu Gly Ala Arg Arg Ser 
1               5                   10                  15      


Ile Asn Ile Ala Gly Val Thr Asp Arg His Gly Arg Trp Gly Cys Glu 
            20                  25                  30          


Ser Cys Val Tyr Thr Arg Asp Gln Ala Gly Asn Arg Ala Arg Cys Ala 
        35                  40                  45              


Pro Cys Asp Gln Ser Thr Tyr Ala Pro Asp Val Gln Glu Val Thr Ile 
    50                  55                  60                  


Gly Gln Arg Gln Ala Lys Tyr Thr Ile Phe Leu Thr Leu Gln Ser Phe 
65                  70                  75                  80  


Ser Trp Thr Asn Thr Met Arg Asn Asn Lys Arg Ala Ala Ala Gly Arg 
                85                  90                  95      


Ser Lys Arg Thr Thr Gly Lys Arg Ile Gly Gln Leu Ala Glu Ile Lys 
            100                 105                 110         


Ile Thr Gly Val Gly Leu Ala His Ala His Asn Val Ile Gln Arg Ser 
        115                 120                 125             


Leu Gln His Asn Ile Thr Lys Met Trp Arg Ala Glu Lys Gly Lys Ser 
    130                 135                 140                 


Lys Arg Val Ala Arg Leu Lys Lys Ala Lys Gln Leu Thr Lys Arg Arg 
145                 150                 155                 160 


Ala Tyr Phe Arg Arg Arg Met Ser Arg Gln Ser Arg Gly Asn Gly Phe 
                165                 170                 175     


Phe Arg Thr Gly Lys Gly Gly Ile His Ala Val Ala Pro Val Lys Ile 
            180                 185                 190         


Gly Leu Asp Val Gly Met Ile Ala Ser Gly Ser Ser Glu Pro Ala Asp 
        195                 200                 205             


Glu Gln Thr Val Thr Leu Asp Ala Ile Trp Lys Gly Arg Lys Lys Lys 
    210                 215                 220                 


Ile Arg Leu Ile Gly Ala Lys Gly Glu Leu Ala Val Ala Ala Cys Arg 
225                 230                 235                 240 


Phe Arg Glu Gln Gln Thr Lys Gly Asp Lys Cys Ile Pro Leu Ile Leu 
                245                 250                 255     


Gln Asp Gly Glu Val Arg Trp Asn Gln Asn Asn Trp Gln Cys His Pro 
            260                 265                 270         


Lys Lys Leu Val Pro Leu Cys Gly Leu Glu Val Ser Arg Lys Phe Val 
        275                 280                 285             


Ser Gln Ala Asp Arg Leu Ala Gln Asn Lys Val Ala Ser Pro Leu Ala 
    290                 295                 300                 


Ala Arg Phe Asp Lys Thr Ser Val Lys Gly Thr Leu Val Glu Ser Asp 
305                 310                 315                 320 


Phe Ala Ala Val Leu Val Asn Val Thr Ser Ile Tyr Gln Gln Cys His 
                325                 330                 335     


Ala Met Leu Leu Arg Ser Gln Glu Pro Thr Pro Ser Leu Arg Val Gln 
            340                 345                 350         


Arg Thr Ile Thr Ser Met 
        355             


<210> 99
<211> 369
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 99
Gly Val Arg Phe Ser Pro Ala Gln Ser Gln Val Phe Phe Arg Thr Val 
1               5                   10                  15      


Ile Pro Gln Ser Val Glu Ala Arg Phe Ala Ile Asn Met Ala Ala Ile 
            20                  25                  30          


His Asp Ala Ala Gly Ala Phe Gly Cys Ser Val Cys Arg Phe Glu Asp 
        35                  40                  45              


Arg Thr Pro Arg Asn Ala Lys Ala Val His Gly Cys Ser Pro Cys Thr 
    50                  55                  60                  


Arg Ser Thr Asn Arg Pro Asp Val Phe Val Leu Pro Val Gly Ala Ile 
65                  70                  75                  80  


Lys Ala Lys Tyr Asp Val Phe Met Arg Leu Leu Gly Phe Asn Trp Thr 
                85                  90                  95      


His Leu Asn Arg Arg Gln Ala Lys Arg Val Thr Val Arg Asp Arg Ile 
            100                 105                 110         


Gly Gln Leu Asp Glu Leu Ala Ile Ser Met Leu Thr Gly Lys Ala Lys 
        115                 120                 125             


Ala Val Leu Lys Lys Ser Ile Cys His Asn Val Asp Lys Ser Phe Lys 
    130                 135                 140                 


Ala Met Arg Gly Ser Leu Lys Lys Leu His Arg Lys Ala Ser Lys Thr 
145                 150                 155                 160 


Gly Lys Ser Gln Leu Arg Ala Lys Leu Ser Asp Leu Arg Glu Arg Thr 
                165                 170                 175     


Asn Thr Thr Gln Glu Gly Ser His Val Glu Gly Asp Ser Asp Val Ala 
            180                 185                 190         


Leu Asn Lys Ile Gly Leu Asp Val Gly Leu Val Gly Lys Pro Asp Tyr 
        195                 200                 205             


Pro Ser Glu Glu Ser Val Glu Val Val Val Cys Leu Tyr Phe Val Gly 
    210                 215                 220                 


Lys Val Leu Ile Leu Asp Ala Gln Gly Arg Ile Arg Asp Met Arg Ala 
225                 230                 235                 240 


Lys Gln Tyr Asp Gly Phe Lys Ile Pro Ile Ile Gln Arg Gly Gln Leu 
                245                 250                 255     


Thr Val Leu Ser Val Lys Asp Leu Gly Lys Trp Ser Leu Val Arg Gln 
            260                 265                 270         


Asp Tyr Val Leu Ala Gly Asp Leu Arg Phe Glu Pro Lys Ile Ser Lys 
        275                 280                 285             


Asp Arg Lys Tyr Ala Glu Cys Val Lys Arg Ile Ala Leu Ile Thr Leu 
    290                 295                 300                 


Gln Ala Ser Leu Gly Phe Lys Glu Arg Ile Pro Tyr Tyr Val Thr Lys 
305                 310                 315                 320 


Gln Val Glu Ile Lys Asn Ala Ser His Ile Ala Phe Val Thr Glu Ala 
                325                 330                 335     


Ile Gln Asn Cys Ala Glu Asn Phe Arg Glu Met Thr Glu Tyr Leu Met 
            340                 345                 350         


Lys Tyr Gln Glu Lys Ser Pro Asp Leu Lys Val Leu Leu Thr Gln Leu 
        355                 360                 365             


Met 
    


<210> 100
<211> 486
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 100
Arg Ala Val Val Gly Lys Val Phe Leu Glu Gln Ala Arg Arg Ala Leu 
1               5                   10                  15      


Asn Leu Ala Thr Asn Phe Gly Thr Asn His Arg Thr Gly Cys Asn Gly 
            20                  25                  30          


Cys Tyr Val Thr Pro Gly Lys Leu Ser Ile Pro Gln Asp Gly Glu Lys 
        35                  40                  45              


Asn Ala Ala Gly Cys Thr Ser Cys Leu Met Lys Ala Thr Ala Ser Tyr 
    50                  55                  60                  


Val Ser Tyr Pro Lys Pro Leu Gly Glu Lys Val Ala Lys Tyr Ser Thr 
65                  70                  75                  80  


Leu Asp Ala Leu Lys Gly Phe Pro Trp Tyr Ser Leu Arg Leu Asn Leu 
                85                  90                  95      


Arg Pro Asn Tyr Arg Gly Lys Pro Ile Asn Gly Val Gln Glu Val Ala 
            100                 105                 110         


Pro Val Ser Lys Phe Arg Leu Ala Glu Glu Val Ile Gln Ala Val Gln 
        115                 120                 125             


Arg Tyr His Phe Thr Glu Leu Glu Gln Ser Phe Pro Gly Gly Arg Arg 
    130                 135                 140                 


Arg Leu Arg Glu Leu Arg Ala Phe Tyr Thr Lys Glu Tyr Arg Arg Ala 
145                 150                 155                 160 


Pro Glu Gln Arg Gln His Val Val Asn Gly Asp Arg Asn Ile Val Val 
                165                 170                 175     


Val Thr Val Leu His Glu Leu Gly Phe Ser Val Gly Met Phe Asn Glu 
            180                 185                 190         


Val Glu Leu Leu Pro Lys Thr Pro Ile Glu Cys Ala Val Asn Val Phe 
        195                 200                 205             


Ile Arg Gly Asn Arg Val Leu Leu Glu Val Arg Lys Pro Gln Phe Asp 
    210                 215                 220                 


Lys Glu Arg Leu Leu Val Glu Ser Leu Trp Lys Lys Asp Ser Arg Arg 
225                 230                 235                 240 


His Thr Ala Lys Trp Thr Pro Pro Asn Asn Glu Gly Arg Ile Phe Thr 
                245                 250                 255     


Ala Glu Gly Trp Lys Asp Phe Gln Leu Pro Leu Leu Leu Gly Ser Thr 
            260                 265                 270         


Ser Arg Ser Leu Arg Ala Ile Glu Lys Glu Gly Phe Val Gln Leu Ala 
        275                 280                 285             


Pro Gly Arg Asp Pro Asp Tyr Asn Asn Thr Ile Asp Glu Gln His Ser 
    290                 295                 300                 


Gly Arg Pro Phe Leu Pro Leu Tyr Leu Tyr Leu Gln Gly Thr Ile Ser 
305                 310                 315                 320 


Gln Glu Tyr Cys Val Phe Ala Gly Thr Trp Val Ile Pro Phe Gln Asp 
                325                 330                 335     


Gly Ile Ser Pro Tyr Ser Thr Lys Asp Thr Phe Gln Pro Asp Leu Lys 
            340                 345                 350         


Arg Lys Ala Tyr Ser Leu Leu Leu Asp Ala Val Lys His Arg Leu Gly 
        355                 360                 365             


Asn Lys Val Ala Ser Gly Leu Gln Tyr Gly Arg Phe Pro Ala Ile Glu 
    370                 375                 380                 


Glu Leu Lys Arg Leu Val Arg Met His Gly Ala Thr Arg Lys Ile Pro 
385                 390                 395                 400 


Arg Gly Glu Lys Asp Leu Leu Lys Lys Gly Asp Pro Asp Thr Pro Glu 
                405                 410                 415     


Trp Trp Leu Leu Glu Gln Tyr Pro Glu Phe Trp Arg Leu Cys Asp Ala 
            420                 425                 430         


Ala Ala Lys Arg Val Ser Gln Asn Val Gly Leu Leu Leu Ser Leu Lys 
        435                 440                 445             


Lys Gln Pro Leu Trp Gln Arg Arg Trp Leu Glu Ser Arg Thr Arg Asn 
    450                 455                 460                 


Glu Pro Leu Asp Asn Leu Pro Leu Ser Met Ala Leu Thr Leu His Leu 
465                 470                 475                 480 


Thr Asn Glu Glu Ala Leu 
                485     


<210> 101
<211> 400
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 101
Ala Ala Val Tyr Ser Lys Phe Tyr Ile Glu Asn His Phe Lys Met Gly 
1               5                   10                  15      


Ile Pro Glu Thr Leu Ser Arg Ile Arg Gly Pro Ser Ile Ile Gln Gly 
            20                  25                  30          


Phe Ser Val Asn Glu Asn Tyr Ile Asn Ile Ala Gly Val Gly Asp Arg 
        35                  40                  45              


Asp Phe Ile Phe Gly Cys Lys Lys Cys Lys Tyr Thr Arg Gly Lys Pro 
    50                  55                  60                  


Ser Ser Lys Lys Ile Asn Lys Cys His Pro Cys Lys Arg Ser Thr Tyr 
65                  70                  75                  80  


Pro Glu Pro Val Ile Asp Val Arg Gly Ser Ile Ser Glu Phe Lys Tyr 
                85                  90                  95      


Lys Ile Tyr Asn Lys Leu Lys Gln Glu Pro Asn Gln Ser Ile Lys Gln 
            100                 105                 110         


Asn Thr Lys Gly Arg Met Asn Pro Ser Asp His Thr Ser Ser Asn Asp 
        115                 120                 125             


Gly Ile Ile Ile Asn Gly Ile Asp Asn Arg Ile Ala Tyr Asn Val Ile 
    130                 135                 140                 


Phe Ser Ser Tyr Lys His Leu Met Glu Lys Gln Ile Asn Leu Leu Arg 
145                 150                 155                 160 


Asp Thr Thr Lys Arg Lys Ala Arg Gln Ile Lys Lys Tyr Asn Asn Ser 
                165                 170                 175     


Gly Lys Lys Lys His Ser Leu Arg Ser Gln Thr Lys Gly Asn Leu Lys 
            180                 185                 190         


Asn Arg Tyr His Met Leu Gly Met Phe Lys Lys Gly Ser Leu Thr Ile 
        195                 200                 205             


Thr Asn Glu Gly Asp Phe Ile Thr Ala Val Arg Lys Val Gly Leu Asp 
    210                 215                 220                 


Ile Ser Leu Tyr Lys Asn Glu Ser Leu Asn Lys Gln Glu Val Glu Thr 
225                 230                 235                 240 


Glu Leu Cys Leu Asn Ile Lys Trp Gly Arg Thr Lys Ser Tyr Thr Val 
                245                 250                 255     


Ser Gly Tyr Ile Pro Leu Pro Ile Asn Ile Asp Trp Lys Leu Tyr Leu 
            260                 265                 270         


Phe Glu Lys Glu Thr Gly Leu Thr Leu Arg Leu Phe Gly Asn Lys Tyr 
        275                 280                 285             


Lys Ile Gln Ser Lys Lys Phe Leu Ile Ala Gln Leu Phe Lys Pro Lys 
    290                 295                 300                 


Arg Pro Pro Cys Ala Asp Pro Val Val Lys Lys Ala Gln Lys Trp Ser 
305                 310                 315                 320 


Ala Leu Asn Ala His Val Gln Gln Met Ala Gly Leu Phe Ser Asp Ser 
                325                 330                 335     


His Leu Leu Lys Arg Glu Leu Lys Asn Arg Met His Lys Gln Leu Asp 
            340                 345                 350         


Phe Lys Ser Leu Trp Val Gly Thr Glu Asp Tyr Ile Lys Trp Phe Glu 
        355                 360                 365             


Glu Leu Ser Arg Ser Tyr Val Glu Gly Ala Glu Lys Ser Leu Glu Phe 
    370                 375                 380                 


Phe Arg Gln Asp Tyr Phe Cys Phe Asn Tyr Thr Lys Gln Thr Thr Met 
385                 390                 395                 400 


<210> 102
<211> 666
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 102
Pro Gln Gln Gln Arg Asp Leu Met Leu Met Ala Ala Asn Tyr Asp Gln 
1               5                   10                  15      


Asp Tyr Gly Asn Gly Cys Gly Pro Cys Thr Val Val Ala Ser Ala Ala 
            20                  25                  30          


Tyr Arg Pro Asp Pro Gln Ala Gln His Gly Cys Lys Arg His Leu Arg 
        35                  40                  45              


Thr Leu Gly Ala Ser Ala Val Thr His Val Gly Leu Gly Asp Arg Thr 
    50                  55                  60                  


Ala Thr Ile Thr Ala Leu His Arg Leu Arg Gly Pro Ala Ala Leu Ala 
65                  70                  75                  80  


Ala Arg Ala Arg Ala Ala Gln Ala Ala Ser Ala Pro Met Thr Pro Asp 
                85                  90                  95      


Thr Asp Ala Pro Asp Asp Arg Arg Arg Leu Glu Ala Ile Asp Ala Asp 
            100                 105                 110         


Asp Val Val Leu Val Gly Ala His Arg Ala Leu Trp Ser Ala Val Arg 
        115                 120                 125             


Arg Trp Ala Asp Asp Arg Arg Ala Ala Leu Arg Arg Arg Leu His Ser 
    130                 135                 140                 


Glu Arg Glu Trp Leu Leu Lys Asp Gln Ile Arg Trp Ala Glu Leu Tyr 
145                 150                 155                 160 


Thr Leu Ile Glu Ala Ser Gly Thr Pro Pro Gln Gly Arg Trp Arg Asn 
                165                 170                 175     


Thr Leu Gly Ala Leu Arg Gly Gln Ser Arg Trp Arg Arg Val Leu Ala 
            180                 185                 190         


Pro Thr Met Arg Ala Thr Cys Ala Glu Thr His Ala Glu Leu Trp Asp 
        195                 200                 205             


Ala Leu Ala Glu Leu Val Pro Glu Met Ala Lys Asp Arg Arg Gly Leu 
    210                 215                 220                 


Leu Arg Pro Pro Val Glu Ala Asp Ala Leu Trp Arg Ala Pro Met Ile 
225                 230                 235                 240 


Val Glu Gly Trp Arg Gly Gly His Ser Val Val Val Asp Ala Val Ala 
                245                 250                 255     


Pro Pro Leu Asp Leu Pro Gln Pro Cys Ala Trp Thr Ala Val Arg Leu 
            260                 265                 270         


Ser Gly Asp Pro Arg Gln Arg Trp Gly Leu His Leu Ala Val Pro Pro 
        275                 280                 285             


Leu Gly Gln Val Gln Pro Pro Asp Pro Leu Lys Ala Thr Leu Ala Val 
    290                 295                 300                 


Ser Met Arg His Arg Gly Gly Val Arg Val Arg Thr Leu Gln Ala Met 
305                 310                 315                 320 


Ala Val Asp Ala Asp Ala Pro Met Gln Arg His Leu Gln Val Pro Leu 
                325                 330                 335     


Thr Leu Gln Arg Gly Gly Gly Leu Gln Trp Gly Ile His Ser Arg Gly 
            340                 345                 350         


Val Arg Arg Arg Glu Ala Arg Ser Met Ala Ser Trp Glu Gly Pro Pro 
        355                 360                 365             


Ile Trp Thr Gly Leu Gln Leu Val Asn Arg Trp Lys Gly Gln Gly Ser 
    370                 375                 380                 


Ala Leu Leu Ala Pro Asp Arg Pro Pro Asp Thr Pro Pro Tyr Ala Pro 
385                 390                 395                 400 


Asp Ala Ala Val Ala Pro Ala Gln Pro Asp Thr Lys Arg Ala Arg Arg 
                405                 410                 415     


Thr Leu Lys Glu Ala Cys Thr Val Cys Arg Cys Ala Pro Gly His Met 
            420                 425                 430         


Arg Gln Leu Gln Val Thr Leu Thr Gly Asp Gly Thr Trp Arg Arg Phe 
        435                 440                 445             


Arg Leu Arg Ala Pro Gln Gly Ala Lys Arg Lys Ala Glu Val Leu Lys 
    450                 455                 460                 


Val Ala Thr Gln His Asp Glu Arg Ile Ala Asn Tyr Thr Ala Trp Tyr 
465                 470                 475                 480 


Leu Lys Arg Pro Glu His Ala Ala Gly Cys Asp Thr Cys Asp Gly Asp 
                485                 490                 495     


Ser Arg Leu Asp Gly Ala Cys Arg Gly Cys Arg Pro Leu Leu Val Gly 
            500                 505                 510         


Asp Gln Cys Phe Arg Arg Tyr Leu Asp Lys Ile Glu Ala Asp Arg Asp 
        515                 520                 525             


Asp Gly Leu Ala Gln Ile Lys Pro Lys Ala Gln Glu Ala Val Ala Ala 
    530                 535                 540                 


Met Ala Ala Lys Arg Asp Ala Arg Ala Gln Lys Val Ala Ala Arg Ala 
545                 550                 555                 560 


Ala Lys Leu Ser Glu Ala Thr Gly Gln Arg Thr Ala Ala Thr Arg Asp 
                565                 570                 575     


Ala Ser His Glu Ala Arg Ala Gln Lys Glu Leu Glu Ala Val Ala Thr 
            580                 585                 590         


Glu Gly Thr Thr Val Arg His Asp Ala Ala Ala Val Ser Ala Phe Gly 
        595                 600                 605             


Ser Trp Val Ala Arg Lys Gly Asp Glu Tyr Arg His Gln Val Gly Val 
    610                 615                 620                 


Leu Ala Asn Arg Leu Glu His Gly Leu Arg Leu Gln Glu Leu Met Ala 
625                 630                 635                 640 


Pro Asp Ser Val Val Ala Asp Gln Gln Arg Ala Ser Gly His Ala Arg 
                645                 650                 655     


Val Gly Tyr Arg Tyr Val Leu Thr Ala Met 
            660                 665     


<210> 103
<211> 560
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 103
Ala Val Ala His Pro Val Gly Arg Gly Asn Ala Gly Ser Pro Gly Ala 
1               5                   10                  15      


Arg Gly Pro Glu Glu Leu Pro Arg Gln Leu Val Asn Arg Ala Ser Asn 
            20                  25                  30          


Val Thr Arg Pro Ala Thr Tyr Gly Cys Ala Pro Cys Arg His Val Arg 
        35                  40                  45              


Leu Ser Ile Pro Lys Pro Val Leu Thr Gly Cys Arg Ala Cys Glu Gln 
    50                  55                  60                  


Thr Thr His Pro Ala Pro Lys Arg Ala Val Arg Gly Gly Ala Asp Ala 
65                  70                  75                  80  


Ala Lys Tyr Asp Leu Ala Ala Phe Phe Ala Gly Trp Ala Ala Asp Leu 
                85                  90                  95      


Glu Gly Arg Asn Arg Arg Arg Gln Val His Ala Pro Leu Asp Pro Gln 
            100                 105                 110         


Pro Asp Pro Asn His Glu Pro Ala Val Thr Leu Gln Lys Ile Asp Leu 
        115                 120                 125             


Ala Glu Val Ser Ile Glu Glu Phe Gln Arg Val Leu Ala Arg Ser Val 
    130                 135                 140                 


Lys His Arg His Asp Gly Arg Ala Ser Arg Glu Arg Glu Lys Ala Arg 
145                 150                 155                 160 


Ala Tyr Ala Gln Val Ala Lys Lys Arg Arg Asn Ser His Ala His Gly 
                165                 170                 175     


Ala Arg Thr Arg Arg Ala Val Arg Arg Gln Thr Arg Ala Val Arg Arg 
            180                 185                 190         


Ala His Arg Met Gly Ala Asn Ser Gly Glu Ile Leu Val Ala Ser Gly 
        195                 200                 205             


Ala Glu Asp Pro Val Pro Glu Ala Ile Asp His Ala Ala Gln Leu Arg 
    210                 215                 220                 


Arg Arg Ile Arg Ala Cys Ala Arg Asp Leu Glu Gly Leu Arg His Leu 
225                 230                 235                 240 


Ser Arg Arg Tyr Leu Lys Thr Leu Glu Lys Pro Cys Arg Arg Pro Arg 
                245                 250                 255     


Ala Pro Asp Leu Gly Arg Ala Arg Cys His Ala Leu Val Glu Ser Leu 
            260                 265                 270         


Gln Ala Ala Glu Arg Glu Leu Glu Glu Leu Arg Arg Cys Asp Ser Pro 
        275                 280                 285             


Asp Thr Ala Met Arg Arg Leu Asp Ala Val Leu Ala Ala Ala Ala Ser 
    290                 295                 300                 


Thr Asp Ala Thr Phe Ala Thr Gly Trp Thr Val Val Gly Met Asp Leu 
305                 310                 315                 320 


Gly Val Ala Pro Arg Gly Ser Ala Ala Pro Glu Val Ser Pro Met Glu 
                325                 330                 335     


Met Ala Ile Ser Val Phe Trp Arg Lys Gly Ser Arg Arg Val Ile Val 
            340                 345                 350         


Ser Lys Pro Ile Ala Gly Met Pro Ile Arg Arg His Glu Leu Ile Arg 
        355                 360                 365             


Leu Glu Gly Leu Gly Thr Leu Arg Leu Asp Gly Asn His Tyr Thr Gly 
    370                 375                 380                 


Ala Gly Val Thr Lys Gly Arg Gly Leu Ser Glu Gly Thr Glu Pro Asp 
385                 390                 395                 400 


Phe Arg Glu Lys Ser Pro Ser Thr Leu Gly Phe Thr Leu Ser Asp Tyr 
                405                 410                 415     


Arg His Glu Ser Arg Trp Arg Pro Tyr Gly Ala Lys Gln Gly Lys Thr 
            420                 425                 430         


Ala Arg Gln Phe Phe Ala Ala Met Ser Arg Glu Leu Arg Ala Leu Val 
        435                 440                 445             


Glu His Gln Val Leu Ala Pro Met Gly Pro Pro Leu Leu Glu Ala His 
    450                 455                 460                 


Glu Arg Arg Phe Glu Thr Leu Leu Lys Gly Gln Asp Asn Lys Ser Ile 
465                 470                 475                 480 


His Ala Gly Gly Gly Gly Arg Tyr Val Trp Arg Gly Pro Pro Asp Ser 
                485                 490                 495     


Lys Lys Arg Pro Ala Ala Asp Gly Asp Trp Phe Arg Phe Gly Arg Gly 
            500                 505                 510         


His Ala Asp His Arg Gly Trp Ala Asn Lys Arg His Glu Leu Ala Ala 
        515                 520                 525             


Asn Tyr Leu Gln Ser Ala Phe Arg Leu Trp Ser Thr Leu Ala Glu Ala 
    530                 535                 540                 


Gln Glu Pro Thr Pro Tyr Ala Arg Tyr Lys Tyr Thr Arg Val Thr Met 
545                 550                 555                 560 


<210> 104
<211> 404
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 104
Trp Asp Phe Leu Thr Leu Gln Val Tyr Glu Arg His Thr Ser Pro Glu 
1               5                   10                  15      


Val Cys Val Ala Gly Asn Ser Thr Lys Cys Ala Ser Gly Thr Arg Lys 
            20                  25                  30          


Ser Asp His Thr His Gly Val Gly Val Lys Leu Gly Ala Gln Glu Ile 
        35                  40                  45              


Asn Val Ser Ala Asn Asp Asp Arg Asp His Glu Val Gly Cys Asn Ile 
    50                  55                  60                  


Cys Val Ile Ser Arg Val Ser Leu Asp Ile Lys Gly Trp Arg Tyr Gly 
65                  70                  75                  80  


Cys Glu Ser Cys Val Gln Ser Thr Pro Glu Trp Arg Ser Ile Val Arg 
                85                  90                  95      


Phe Asp Arg Asn His Lys Glu Ala Lys Gly Glu Cys Leu Ser Arg Phe 
            100                 105                 110         


Glu Tyr Trp Gly Ala Gln Ser Ile Ala Arg Ser Leu Lys Arg Asn Lys 
        115                 120                 125             


Leu Met Gly Gly Val Asn Leu Asp Glu Leu Ala Ile Val Gln Asn Glu 
    130                 135                 140                 


Asn Val Val Lys Thr Ser Leu Lys His Leu Phe Asp Lys Arg Lys Asp 
145                 150                 155                 160 


Arg Ile Gln Ala Asn Leu Lys Ala Val Lys Val Arg Met Arg Glu Arg 
                165                 170                 175     


Arg Lys Ser Gly Arg Gln Arg Lys Ala Leu Arg Arg Gln Cys Arg Lys 
            180                 185                 190         


Leu Lys Arg Tyr Leu Arg Ser Tyr Asp Pro Ser Asp Ile Lys Glu Gly 
        195                 200                 205             


Asn Ser Cys Ser Ala Phe Thr Lys Leu Gly Leu Asp Ile Gly Ile Ser 
    210                 215                 220                 


Pro Asn Lys Pro Pro Lys Ile Glu Pro Lys Val Glu Val Val Phe Ser 
225                 230                 235                 240 


Leu Phe Tyr Gln Gly Ala Cys Asp Lys Ile Val Thr Val Ser Ser Pro 
                245                 250                 255     


Glu Ser Pro Leu Pro Arg Ser Trp Lys Ile Lys Ile Asp Gly Ile Arg 
            260                 265                 270         


Ala Leu Tyr Val Lys Ser Thr Lys Val Lys Phe Gly Gly Arg Thr Phe 
        275                 280                 285             


Arg Ala Gly Gln Arg Asn Asn Arg Arg Lys Val Arg Pro Pro Asn Val 
    290                 295                 300                 


Lys Lys Gly Lys Arg Lys Gly Ser Arg Ser Gln Phe Phe Asn Lys Phe 
305                 310                 315                 320 


Ala Val Gly Leu Asp Ala Val Ser Gln Gln Leu Pro Ile Ala Ser Val 
                325                 330                 335     


Gln Gly Leu Trp Gly Arg Ala Glu Thr Lys Lys Ala Gln Thr Ile Cys 
            340                 345                 350         


Leu Lys Gln Leu Glu Ser Asn Lys Pro Leu Lys Glu Ser Gln Arg Cys 
        355                 360                 365             


Leu Phe Leu Ala Asp Asn Trp Val Val Arg Val Cys Gly Phe Leu Arg 
    370                 375                 380                 


Ala Leu Ser Gln Arg Gln Gly Pro Thr Pro Tyr Ile Arg Tyr Arg Tyr 
385                 390                 395                 400 


Arg Cys Asn Met 
                


<210> 105
<211> 392
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 105
Ala Arg Asn Val Gly Gln Arg Asn Ala Ser Arg Gln Ser Lys Arg Glu 
1               5                   10                  15      


Ser Ala Lys Ala Arg Ser Arg Arg Val Thr Gly Gly His Ala Ser Val 
            20                  25                  30          


Thr Gln Gly Val Ala Leu Ile Asn Ala Ala Ala Asn Ala Asp Arg Asp 
        35                  40                  45              


His Thr Thr Gly Cys Glu Pro Cys Thr Trp Glu Arg Val Asn Leu Pro 
    50                  55                  60                  


Leu Gln Glu Val Ile His Gly Cys Asp Ser Cys Thr Lys Ser Ser Pro 
65                  70                  75                  80  


Phe Trp Arg Asp Ile Lys Val Val Asn Lys Gly Tyr Arg Glu Ala Lys 
                85                  90                  95      


Glu Glu Ile Met Arg Ile Ala Ser Gly Ile Ser Ala Asp His Leu Ser 
            100                 105                 110         


Arg Ala Leu Ser His Asn Lys Val Met Gly Arg Leu Asn Leu Asp Glu 
        115                 120                 125             


Val Cys Ile Leu Asp Phe Arg Thr Val Leu Asp Thr Ser Leu Lys His 
    130                 135                 140                 


Leu Thr Asp Ser Arg Ser Asn Gly Ile Lys Glu His Ile Arg Ala Val 
145                 150                 155                 160 


His Arg Lys Ile Arg Met Arg Arg Lys Ser Gly Lys Thr Ala Arg Ala 
                165                 170                 175     


Leu Arg Lys Gln Tyr Phe Ala Leu Arg Arg Gln Trp Lys Ala Gly His 
            180                 185                 190         


Lys Pro Asn Ser Ile Arg Glu Gly Asn Ser Leu Thr Ala Leu Arg Ala 
        195                 200                 205             


Val Gly Phe Asp Val Gly Val Ser Glu Gly Thr Glu Pro Met Pro Ala 
    210                 215                 220                 


Pro Gln Thr Glu Val Val Leu Ser Val Phe Tyr Lys Gly Ser Ala Thr 
225                 230                 235                 240 


Arg Ile Leu Arg Ile Ser Ser Pro His Pro Ile Ala Lys Arg Ser Trp 
                245                 250                 255     


Lys Val Lys Ile Ala Gly Ile Lys Ala Leu Lys Leu Ile Arg Arg Glu 
            260                 265                 270         


His Asp Phe Ser Phe Gly Arg Glu Thr Tyr Asn Ala Ser Gln Arg Ala 
        275                 280                 285             


Glu Lys Arg Lys Phe Ser Pro His Ala Ala Arg Lys Asp Phe Phe Asn 
    290                 295                 300                 


Ser Phe Ala Val Gln Leu Asp Arg Leu Ala Gln Gln Leu Cys Val Ser 
305                 310                 315                 320 


Ser Val Glu Asn Leu Trp Val Thr Glu Pro Gln Gln Lys Leu Leu Thr 
                325                 330                 335     


Leu Ala Lys Asp Thr Ala Pro Tyr Gly Ile Arg Glu Gly Ala Arg Phe 
            340                 345                 350         


Ala Asp Thr Arg Ala Arg Leu Ala Trp Asn Trp Val Phe Arg Val Cys 
        355                 360                 365             


Gly Phe Thr Arg Ala Leu His Gln Glu Gln Glu Pro Thr Pro Tyr Cys 
    370                 375                 380                 


Arg Phe Thr Trp Arg Ser Lys Met 
385                 390         


<210> 106
<211> 492
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 106
Met Ala Gly Lys Lys Lys Asp Lys Asp Val Ile Asn Lys Thr Leu Ser 
1               5                   10                  15      


Val Arg Ile Ile Arg Pro Arg Tyr Ser Asp Asp Ile Glu Lys Glu Ile 
            20                  25                  30          


Ser Asp Glu Lys Ala Lys Arg Lys Gln Asp Gly Lys Thr Gly Glu Leu 
        35                  40                  45              


Asp Arg Ala Phe Phe Ser Glu Leu Lys Ser Arg Asn Pro Asp Ile Ile 
    50                  55                  60                  


Thr Asn Asp Glu Leu Phe Pro Leu Phe Thr Glu Ile Gln Lys Asn Leu 
65                  70                  75                  80  


Thr Glu Ile Tyr Asn Lys Ser Ile Ser Leu Leu Tyr Met Lys Leu Ile 
                85                  90                  95      


Val Glu Glu Glu Gly Gly Ser Thr Ala Ser Ala Leu Ser Ala Gly Pro 
            100                 105                 110         


Tyr Lys Glu Cys Lys Ala Arg Phe Asn Ser Tyr Ile Ser Leu Gly Leu 
        115                 120                 125             


Arg Gln Lys Ile Gln Ser Asn Phe Arg Arg Lys Glu Leu Lys Gly Phe 
    130                 135                 140                 


Gln Val Ser Leu Pro Thr Ala Lys Ser Asp Arg Phe Pro Ile Pro Phe 
145                 150                 155                 160 


Cys His Gln Val Glu Asn Gly Lys Gly Gly Phe Lys Val Tyr Glu Thr 
                165                 170                 175     


Gly Asp Asp Phe Ile Phe Glu Val Pro Leu Ile Lys Tyr Thr Ala Thr 
            180                 185                 190         


Asn Lys Lys Ser Thr Ser Gly Lys Asn Tyr Thr Lys Val Gln Leu Asn 
        195                 200                 205             


Asn Pro Pro Val Pro Met Asn Val Pro Leu Leu Leu Ser Thr Met Arg 
    210                 215                 220                 


Arg Arg Gln Thr Lys Lys Gly Met Gln Trp Asn Lys Asp Glu Gly Thr 
225                 230                 235                 240 


Asn Ala Glu Leu Arg Arg Val Met Ser Gly Glu Tyr Lys Val Ser Tyr 
                245                 250                 255     


Ala Glu Ile Ile Arg Arg Thr Arg Phe Gly Lys His Asp Asp Trp Phe 
            260                 265                 270         


Val Asn Phe Ser Ile Lys Phe Lys Asn Lys Thr Asp Glu Leu Asn Gln 
        275                 280                 285             


Asn Val Arg Gly Gly Ile Asp Ile Gly Val Ser Asn Pro Leu Val Cys 
    290                 295                 300                 


Ala Val Thr Asn Gly Leu Asp Arg Tyr Ile Val Ala Asn Asn Asp Ile 
305                 310                 315                 320 


Met Ala Phe Asn Glu Arg Ala Met Ala Arg Arg Arg Thr Leu Leu Arg 
                325                 330                 335     


Lys Asn Arg Phe Lys Arg Ser Gly His Gly Ala Lys Asn Lys Leu Glu 
            340                 345                 350         


Pro Ile Thr Val Leu Thr Glu Lys Asn Glu Arg Phe Arg Lys Ser Ile 
        355                 360                 365             


Leu Gln Arg Trp Ala Arg Glu Val Ala Glu Phe Phe Lys Arg Thr Ser 
    370                 375                 380                 


Ala Ser Val Val Asn Met Glu Asp Leu Ser Gly Ile Thr Glu Arg Glu 
385                 390                 395                 400 


Asp Phe Phe Ser Thr Lys Leu Arg Thr Thr Trp Asn Tyr Arg Leu Met 
                405                 410                 415     


Gln Thr Thr Ile Glu Asn Lys Leu Lys Glu Tyr Gly Ile Ala Val Asn 
            420                 425                 430         


Tyr Ile Ser Pro Lys Tyr Thr Ser Gln Thr Cys His Ser Cys Gly Lys 
        435                 440                 445             


Arg Asn Asp Tyr Phe Thr Phe Ser Tyr Arg Ser Glu Asn Asn Tyr Pro 
    450                 455                 460                 


Pro Phe Glu Cys Lys Glu Cys Asn Lys Val Lys Cys Asn Ala Asp Phe 
465                 470                 475                 480 


Asn Ala Ala Lys Asn Ile Ala Leu Lys Val Val Leu 
                485                 490         


<210> 107
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 107
Met Arg Ile Ser Lys Thr Leu Ser Leu Arg Ile Val Arg Pro Phe Tyr 
1               5                   10                  15      


Thr Pro Glu Val Glu Ala Gly Ile Lys Ala Glu Lys Asp Lys Arg Glu 
            20                  25                  30          


Ala Gln Gly Gln Thr Arg Ser Leu Asp Ala Lys Phe Phe Asn Glu Leu 
        35                  40                  45              


Lys Lys Lys His Ser Glu Ile Ile Leu Ser Ser Glu Phe Tyr Ser Leu 
    50                  55                  60                  


Leu Ser Glu Val Gln Arg Gln Leu Thr Ser Ile Tyr Asn His Ala Met 
65                  70                  75                  80  


Ser Asn Leu Tyr His Lys Ile Ile Val Glu Gly Glu Lys Thr Ser Thr 
                85                  90                  95      


Ser Lys Ala Leu Ser Asn Ile Gly Tyr Asp Glu Cys Lys Ala Ile Phe 
            100                 105                 110         


Pro Ser Tyr Met Ala Leu Gly Leu Arg Gln Lys Ile Gln Ser Asn Phe 
        115                 120                 125             


Arg Arg Arg Asp Leu Lys Asn Phe Arg Met Ala Val Pro Thr Ala Lys 
    130                 135                 140                 


Ser Asp Lys Phe Pro Ile Pro Ile Tyr Arg Gln Val Asp Gly Ser Lys 
145                 150                 155                 160 


Gly Gly Phe Lys Ile Ser Glu Asn Asp Gly Lys Asp Phe Ile Val Glu 
                165                 170                 175     


Leu Pro Leu Val Asp Tyr Val Ala Glu Glu Val Lys Thr Ala Lys Gly 
            180                 185                 190         


Arg Phe Thr Lys Ile Asn Ile Ser Lys Pro Pro Lys Ile Lys Asn Ile 
        195                 200                 205             


Pro Val Ile Leu Ser Thr Leu Arg Arg Arg Gln Ser Gly Gln Trp Phe 
    210                 215                 220                 


Ser Asp Asp Gly Thr Asn Ala Glu Ile Arg Arg Val Ile Ser Gly Glu 
225                 230                 235                 240 


Tyr Lys Val Ser Trp Ile Glu Ile Val Arg Arg Thr Arg Phe Gly Lys 
                245                 250                 255     


His Asp Asp Trp Phe Val Asn Met Val Ile Lys Tyr Asp Lys Pro Glu 
            260                 265                 270         


Glu Gly Leu Asp Ser Lys Val Val Gly Gly Ile Asp Val Gly Val Ser 
        275                 280                 285             


Ser Pro Leu Val Cys Ala Leu Asn Asn Ser Leu Asp Arg Tyr Phe Val 
    290                 295                 300                 


Lys Ser Ser Asp Ile Ile Ala Phe Asn Lys Arg Ala Met Ala Arg Arg 
305                 310                 315                 320 


Arg Thr Leu Leu Arg Gln Asn Lys Tyr Lys Arg Ser Gly His Gly Ser 
                325                 330                 335     


Lys Asn Lys Leu Glu Pro Ile Thr Val Leu Thr Glu Lys Asn Glu Arg 
            340                 345                 350         


Phe Lys Lys Ser Ile Met Gln Arg Trp Ala Lys Glu Val Ala Glu Phe 
        355                 360                 365             


Phe Arg Gly Lys Gly Ala Ser Val Val Arg Met Glu Glu Leu Ser Gly 
    370                 375                 380                 


Leu Lys Glu Lys Asp Asn Phe Phe Ser Ser Tyr Leu Arg Met Tyr Trp 
385                 390                 395                 400 


Asn Tyr Gly Gln Leu Gln Gln Ile Ile Glu Asn Lys Leu Lys Glu Tyr 
                405                 410                 415     


Gly Ile Lys Val Asn Tyr Val Ser Pro Lys Asp Thr Ser Lys Lys Cys 
            420                 425                 430         


His Ser Cys Thr His Ile Asn Glu Phe Phe Thr Phe Glu Tyr Arg Gln 
        435                 440                 445             


Lys Asn Asn Phe Pro Leu Phe Lys Cys Glu Lys Cys Gly Val Glu Cys 
    450                 455                 460                 


Ser Ala Asp Tyr Asn Ala Ala Lys Asn Met Ala Ile Ala 
465                 470                 475         


<210> 108
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 108
Val Lys Ile Ser Lys Thr Leu Ser Leu Arg Ile Ile Arg Pro Tyr Tyr 
1               5                   10                  15      


Thr Pro Glu Val Glu Ser Ala Ile Lys Ala Glu Lys Asp Lys Arg Glu 
            20                  25                  30          


Ala Gln Gly Gln Thr Arg Asn Leu Asp Ala Lys Phe Phe Asn Glu Leu 
        35                  40                  45              


Lys Lys Lys His Pro Gln Ile Ile Leu Ser Gly Glu Phe Tyr Ser Leu 
    50                  55                  60                  


Leu Phe Glu Met Gln Arg Gln Leu Thr Ser Ile Tyr Asn Arg Ala Met 
65                  70                  75                  80  


Ser Ser Leu Tyr His Lys Ile Ile Val Glu Gly Glu Lys Thr Ser Thr 
                85                  90                  95      


Ser Lys Ala Leu Ser Asp Ile Gly Tyr Asp Glu Cys Lys Ser Val Phe 
            100                 105                 110         


Pro Ser Tyr Ile Ala Leu Gly Leu Arg Gln Lys Ile Gln Ser Asn Phe 
        115                 120                 125             


Arg Arg Lys Glu Leu Lys Gly Phe Arg Met Ala Val Pro Thr Ala Lys 
    130                 135                 140                 


Ser Asp Lys Phe Pro Ile Pro Ile Tyr Lys Gln Val Asp Asp Gly Lys 
145                 150                 155                 160 


Gly Gly Phe Lys Ile Ser Glu Asn Lys Glu Gly Asp Phe Ile Val Glu 
                165                 170                 175     


Leu Pro Leu Val Glu Tyr Thr Ala Glu Asp Val Lys Thr Ala Lys Gly 
            180                 185                 190         


Lys Phe Thr Lys Ile Asn Ile Ser Lys Pro Pro Lys Ile Lys Asn Ile 
        195                 200                 205             


Pro Val Ile Leu Ser Thr Leu Arg Arg Lys Gln Ser Gly Gln Trp Phe 
    210                 215                 220                 


Ser Asp Glu Gly Thr Asn Ala Glu Ile Arg Arg Val Ile Ser Gly Glu 
225                 230                 235                 240 


Tyr Lys Val Ser Trp Ile Glu Val Val Arg Arg Thr Arg Phe Gly Lys 
                245                 250                 255     


His Asp Asp Trp Phe Leu Asn Ile Val Ile Lys Tyr Asp Lys Thr Glu 
            260                 265                 270         


Asp Gly Leu Asp Pro Glu Val Val Gly Gly Ile Asp Val Gly Val Ser 
        275                 280                 285             


Thr Pro Leu Val Cys Ala Val Asn Asn Ser Leu Asp Arg Tyr Phe Val 
    290                 295                 300                 


Lys Ser Ser Asp Ile Ile Ala Phe Lys Lys Arg Ala Met Ala Arg Arg 
305                 310                 315                 320 


Arg Thr Leu Leu Arg Gln Asn Arg Phe Lys Arg Ser Gly His Gly Ser 
                325                 330                 335     


Lys Ser Lys Leu Glu Pro Ile Thr Ile Leu Thr Glu Lys Asn Glu Arg 
            340                 345                 350         


Phe Lys Lys Ser Ile Met Gln Arg Trp Ala Lys Glu Val Ala Glu Phe 
        355                 360                 365             


Phe Lys Gly Glu Arg Ala Ser Val Val Gln Met Glu Glu Leu Ser Gly 
    370                 375                 380                 


Leu Lys Glu Lys Asp Asn Phe Phe Gly Ser Tyr Leu Arg Met Tyr Trp 
385                 390                 395                 400 


Asn Tyr Gly Gln Leu Gln Gln Ile Ile Glu Asn Lys Leu Lys Glu Tyr 
                405                 410                 415     


Gly Ile Lys Val Asn Tyr Val Ser Pro Lys Asp Thr Ser Lys Lys Cys 
            420                 425                 430         


His Ser Cys Gly Tyr Ile Asn Glu Phe Phe Thr Phe Glu Phe Arg Gln 
        435                 440                 445             


Lys Asn Asn Phe Pro Leu Phe Lys Cys Lys Lys Cys Gly Val Glu Cys 
    450                 455                 460                 


Asn Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ala Ile Ala 
465                 470                 475         


<210> 109
<211> 472
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 109
Val Pro Ile Thr Lys Thr Ile Ser Leu Arg Ile Leu Arg Pro Tyr Tyr 
1               5                   10                  15      


Pro Pro Glu Ile Glu Ala Lys Ile Lys Ala Glu Lys Glu Lys Arg Lys 
            20                  25                  30          


Glu Asn Gly Asp Thr Gly Ser Leu Asn Ser Ser Tyr Tyr Arg Glu Leu 
        35                  40                  45              


Lys Lys Glu Tyr Pro Ser Ile Ile Ile Asn Asp Glu Phe Phe Pro Leu 
    50                  55                  60                  


Leu Ser Glu Met Gln Arg Asn Ile Thr Ser Ile Tyr Asn Arg Thr Ile 
65                  70                  75                  80  


Ser His Leu Tyr His Arg Leu Ile Ile Lys Lys Glu Ser Ile Ser Thr 
                85                  90                  95      


Ala Lys Ala Leu Ser Glu Gly Pro Tyr Arg Asp Phe Lys Ser Thr Phe 
            100                 105                 110         


Asn Ser Tyr Ile Ala Leu Gly Leu Arg Gln Lys Val Gln Ser Asn Phe 
        115                 120                 125             


Arg Lys Lys Asp Leu Met Ala Phe Lys Ile Ala Leu Pro Thr Ala Lys 
    130                 135                 140                 


Ser Asp Lys Phe Pro Ile Pro Ile Tyr Met Gln Thr Asn Phe Lys Ile 
145                 150                 155                 160 


Lys Glu Ser Pro Asp Ser Asp Phe Ile Ile Glu Leu Pro Leu Val Glu 
                165                 170                 175     


Tyr Ile Ala Lys Glu Thr Lys Gly Lys Asn Lys Met Phe Thr Lys Val 
            180                 185                 190         


Glu Ile Leu Ser Pro Pro Lys Val Lys Asn Ile Pro Val Ile Leu Ser 
        195                 200                 205             


Thr Arg Arg Arg Lys Glu Ser Gly Gln Trp Phe Ser Asp Glu Gly Thr 
    210                 215                 220                 


Asn Ala Glu Ile Arg Arg Ile Ile Ser Gly Glu Tyr Lys Val Ser Trp 
225                 230                 235                 240 


Ile Glu Ile Val Lys Arg Thr Arg Phe Gly Lys His Asp Trp Phe Val 
                245                 250                 255     


Asn Met Val Ile Ser Phe Glu Glu Ser Gln Glu Gly Leu Asp Pro Asp 
            260                 265                 270         


Val Ile Gly Gly Ile Asp Ile Gly Val Ser Lys Pro Leu Ile Cys Ala 
        275                 280                 285             


Ile Asn Asn Ser Leu Asp Arg Tyr Ile Val Lys Gly Asp Asp Ile Ile 
    290                 295                 300                 


Ala Phe Asn Arg Arg Ala Leu Ser Arg Arg Arg Ser Leu Leu Arg Arg 
305                 310                 315                 320 


Asn Arg Leu Lys Arg Ser Gly His Gly Ser Arg Asn Lys Leu Glu Pro 
                325                 330                 335     


Ile Thr Val Leu Thr Glu Lys Asn Glu Arg Phe Lys Lys Ser Ile Met 
            340                 345                 350         


Gln Arg Trp Ala Lys Glu Val Ala Glu Phe Phe Lys Ser Lys Arg Ala 
        355                 360                 365             


Ser Ile Val Gln Met Glu Glu Leu Thr Gly Ile Lys Glu Arg Glu Asp 
    370                 375                 380                 


Phe Phe Ser Lys Thr Leu Arg Met Tyr Trp Asn Tyr Gly Gln Leu Gln 
385                 390                 395                 400 


Lys Thr Val Glu Asn Lys Leu Arg Glu Tyr Gly Ile Glu Val Arg Tyr 
                405                 410                 415     


Ala Ser Pro Lys Asp Thr Ser Arg Arg Cys His Ser Cys Gly His Ile 
            420                 425                 430         


Asn Asp Tyr Phe Thr Phe Glu Phe Arg Gln Gln Asn Asn Phe Pro Leu 
        435                 440                 445             


Phe Lys Cys Met Asn Cys Gly Ile Glu Cys Ser Ala Asp Tyr Asn Ala 
    450                 455                 460                 


Ala Arg Asn Ile Ala Ile Ala Arg 
465                 470         


<210> 110
<211> 455
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 110
Met Ala Lys Lys Gly Thr Asn Arg Lys Lys Met Ile Val Lys Val Met 
1               5                   10                  15      


Lys Tyr Glu Leu Lys Tyr Glu Ser Gly Cys Ala Asp Phe Asn Glu Met 
            20                  25                  30          


Gln Asn Glu Leu Trp Lys Leu Gln Arg Gln Thr Arg Glu Val Met Asn 
        35                  40                  45              


Arg Thr Ile Gln Leu Cys Tyr His Trp Ser Tyr Val Gln Ala Asp Tyr 
    50                  55                  60                  


Cys Lys Gln His Gly Cys Ala Arg Arg Asp Val Lys Pro Cys Asp Val 
65                  70                  75                  80  


Tyr Glu Thr Asn Ala Thr Ser Leu Asp Gly Tyr Ile Tyr Gln Leu Phe 
                85                  90                  95      


Lys Asp Glu Tyr Pro Asn Phe Leu Met Ala Asn Leu Ile Ala Thr Leu 
            100                 105                 110         


Arg Lys Ala His Gln Lys Tyr Asp Ala Leu Leu Phe Asp Ile Gln Glu 
        115                 120                 125             


Gly Asn Ser Ser Ile Pro Ser Phe Lys Lys Asp Gln Pro Leu Ile Phe 
    130                 135                 140                 


Ser Lys Glu Ala Ile Arg Leu Pro Glu Cys Leu Ser Asp Lys Arg Gln 
145                 150                 155                 160 


Ile Thr Leu Phe Cys Phe Ser Lys Pro Tyr Lys Ser Ala His Pro Thr 
                165                 170                 175     


Leu Asp Lys Ile Thr Phe Ala Val Arg Ala Arg Ser Ala Ser Glu Lys 
            180                 185                 190         


Ser Ile Phe Asp His Ile Ile Ser Gly Lys Tyr Ala Leu Gly Glu Ser 
        195                 200                 205             


Gln Leu Val Tyr Glu Lys Lys Lys Trp Phe Phe Leu Leu Ser Tyr Lys 
    210                 215                 220                 


Phe Thr Pro Glu Ser Val Asp Val Asn Pro Glu Lys Val Leu Gly Val 
225                 230                 235                 240 


Asp Leu Gly Val Val Asn Ala Leu Cys Ala Gly Ser Val Glu Asn Pro 
                245                 250                 255     


His Asp Ser Leu Phe Ile Lys Gly Thr Glu Ala Ile Glu Gln Ile Arg 
            260                 265                 270         


Arg Leu Glu Ala Arg Lys Arg Asp Leu Gln Lys Gln Ala Arg Tyr Pro 
        275                 280                 285             


Gly Asp Gly Arg Ile Gly His Gly Thr Lys Thr Arg Val Ser Pro Val 
    290                 295                 300                 


Tyr Gln Thr Arg Asp Ala Ile Ala Arg Met Gln Asp Thr Leu Asn His 
305                 310                 315                 320 


Arg Trp Ser Arg Ala Leu Ile Asp Phe Ala Cys Lys Lys Gly Tyr Gly 
                325                 330                 335     


Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Ala Leu Glu Ser Glu 
            340                 345                 350         


Lys Pro Tyr Leu Lys His Trp Thr Tyr Phe Asp Leu Gln Ser Lys Ile 
        355                 360                 365             


Ile Tyr Lys Ala Glu Glu Lys Gly Ile Arg Val Val Lys Val Asn Pro 
    370                 375                 380                 


Lys Cys Thr Ser Arg Arg Cys Ser Ala Cys Gly Tyr Ile Ser Lys Glu 
385                 390                 395                 400 


Asn Arg Lys Asn Gln Val Glu Phe Leu Cys Val Asn Cys Gly Tyr His 
                405                 410                 415     


His Asn Ala Asp Tyr Asn Ala Ala Gln Asn Leu Ser Ile Pro Gln Ile 
            420                 425                 430         


Asp Arg Leu Ile Glu Lys Gln Leu Lys Glu Gln Glu Ser Glu Glu Asn 
        435                 440                 445             


Glu Ala Gly Ala Asn Pro Lys 
    450                 455 


<210> 111
<211> 410
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 111
Met Ala Lys Gly Thr Leu Ser Lys Val Met Lys Tyr Glu Leu Arg Tyr 
1               5                   10                  15      


Leu Asp Gly Cys Gly Asp Phe Gln Asn Met Gln Lys Glu Leu Trp Thr 
            20                  25                  30          


Leu Gln Arg Gln Ser Arg Glu Ile Leu Asn Arg Thr Ile Gln Ile Ala 
        35                  40                  45              


Tyr His Trp Asp Tyr Thr Asp Arg Glu Gln Phe Lys Lys Thr Gly Gln 
    50                  55                  60                  


His Leu Asp Ile Lys Ala Glu Thr Gly Tyr Lys Arg Leu Asp Gly Tyr 
65                  70                  75                  80  


Ile Tyr Asp Ser Leu Lys Glu Asp Val Gln Asn Phe Ala Ser Val Asn 
                85                  90                  95      


Val Asn Ala Thr Ile Gln Lys Ala Trp Ala Lys Tyr Lys Ser Ser Lys 
            100                 105                 110         


Ile Asp Val Leu Arg Gly Asp Met Ser Leu Pro Ser Tyr Lys Ser Asp 
        115                 120                 125             


Gln Pro Leu Val Leu His Ala Gln Ser Met Lys Ile Phe Ser Ser Asp 
    130                 135                 140                 


Asp Asp Asp Val Leu Gln Val Thr Leu Phe Ser Asn Ala Tyr Lys Lys 
145                 150                 155                 160 


Ala Cys Asn Tyr Ser Asn Ile Arg Phe Ile Ile Gly Leu His Asp Ala 
                165                 170                 175     


Thr Gln Arg Thr Ile Ile Lys Lys Val Leu Ser Gly Asp Trp Gly Ile 
            180                 185                 190         


Gly Gln Ser Gln Ile Val Tyr Lys Arg Pro Lys Trp Phe Leu Tyr Leu 
        195                 200                 205             


Thr Tyr Asn Phe Ser Pro Glu Gln His Glu Val Asn Pro Asp Lys Ile 
    210                 215                 220                 


Leu Gly Val Asp Leu Gly Glu Ser Ile Ala Ile Tyr Ala Ser Ser Ile 
225                 230                 235                 240 


Gly Glu Tyr Gly Ser Leu Arg Ile Glu Gly Gly Glu Ile Ser Ala Phe 
                245                 250                 255     


Ala Lys Gln Leu Glu Ala Arg Lys Arg Ser Leu Gln Lys Gln Ala Ala 
            260                 265                 270         


Tyr Cys Gly Lys Gly Arg Ile Gly His Gly Thr Lys Ser Arg Val Ser 
        275                 280                 285             


Asp Val Tyr Lys Met Glu Asp Lys Ile Ala Asn Phe Arg Asn Thr Val 
    290                 295                 300                 


Asn His Arg Tyr Ser Lys Met Leu Ile Asp Tyr Ala Leu Lys His Met 
305                 310                 315                 320 


Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Lys Glu Thr 
                325                 330                 335     


Gly Phe Pro Lys Phe Leu Gln His Trp Thr Tyr Tyr Asp Leu Gln Gln 
            340                 345                 350         


Lys Ile Glu Ala Lys Ala Lys Glu His Gly Ile Asn Phe Ile Lys Val 
        355                 360                 365             


Asp Pro Ala Phe Thr Ser Gln Arg Cys Ser Lys Cys Gly Asn Ile Asp 
    370                 375                 380                 


Ser Glu Asn Arg Pro Ser Gln Ala Val Phe Cys Cys Lys Lys Cys Gly 
385                 390                 395                 400 


Tyr Lys Thr Asn Ala Asp Phe Asn Ala Ser 
                405                 410 


<210> 112
<211> 426
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 112
Met Asn Val Thr Lys Val Met Arg Tyr Gln Leu Ile Tyr Gln Gly Gly 
1               5                   10                  15      


Gly Gly Asp Phe Glu Ser Leu Gln Asn Gln Leu Trp Glu Phe Gln Arg 
            20                  25                  30          


Gln Thr Arg Ala Ile Leu Asn Lys Thr Ile Gln Thr Met Tyr Leu Ala 
        35                  40                  45              


Thr Ala Asn Gln Glu Lys Phe Ser Glu Lys Ala Leu Tyr His Asp Leu 
    50                  55                  60                  


Cys Ala Glu Tyr Pro Asp Met Ile Ser Ser Thr Val Asn Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Ala Thr Lys Lys Tyr Arg Ser Ser Val Arg Glu Ile Leu Ala 
                85                  90                  95      


Gly Arg Met Ser Leu Pro Ser Tyr Lys Arg Asp His Pro Ile Leu Leu 
            100                 105                 110         


His Asn Gln Ser Val Ala Leu Lys Gln Gly Asn Gln Gly Ser Tyr Phe 
        115                 120                 125             


Ala Thr Ile Ser Val Phe Ser Arg Lys Tyr Gln Gln Gly Thr Pro Gly 
    130                 135                 140                 


Val Lys Gln Pro Ser Phe Gln Leu Ile Ala Lys Asp Asn Thr Gln Arg 
145                 150                 155                 160 


Thr Ile Leu Gln Arg Leu Leu Ser Gly Glu Tyr Lys Leu Gly Gln Cys 
                165                 170                 175     


Gln Leu Ile Tyr Ile Arg Pro Lys Trp Phe Leu Asn Val Ala Tyr Ser 
            180                 185                 190         


Phe Thr Pro Ser Glu Lys Ala Leu Asp Gln Glu Lys Val Leu Gly Val 
        195                 200                 205             


Asp Leu Gly Cys Val Tyr Ala Ile Tyr Ala Ser Ser Tyr Gly Asn His 
    210                 215                 220                 


Gly Ile Phe Lys Ile Ser Gly Asp Glu Ile Thr Ser Phe Glu Arg Lys 
225                 230                 235                 240 


Gln Ala Ala Ile Gln Asn Arg Ala Phe Lys Asn Asp Leu Thr Arg Ile 
                245                 250                 255     


Arg Glu Ile Glu Glu Arg Arg Lys Gln Lys Leu Glu Gln Ala Arg Tyr 
            260                 265                 270         


Cys Gly Glu Gly Arg Ile Gly His Gly Val Lys Thr Arg Val Ala Pro 
        275                 280                 285             


Ala Tyr Gln Asp Glu Gly Lys Ile Ser Arg Phe Arg Glu Thr Ile Asn 
    290                 295                 300                 


His Arg Tyr Ser Lys Ala Leu Val Asp Tyr Ala Glu Lys Asn Gly Tyr 
305                 310                 315                 320 


Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Ser Ser Thr Gly 
                325                 330                 335     


Phe Pro Lys Arg Leu Gln His Trp Thr Tyr Phe Asp Leu Gln Gln Lys 
            340                 345                 350         


Ile Lys Tyr Lys Ala Glu Glu Gln Gly Ile Lys Val Val Lys Ile Lys 
        355                 360                 365             


Pro Ala Tyr Thr Ser Gln Arg Cys Ser Arg Cys Gly His Ile Asp Pro 
    370                 375                 380                 


Ala Asn Arg Lys Ser Gln Ser Glu Phe Lys Cys Ile Ala Cys Gly Phe 
385                 390                 395                 400 


Ser Ser Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ser Met Arg Asn 
                405                 410                 415     


Ile Glu Lys Ile Ile Gln Gly Lys Ala Asn 
            420                 425     


<210> 113
<211> 432
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 113
Met Ala Lys Gly Thr Ile Thr Lys Val Met Lys Tyr Glu Leu Arg Tyr 
1               5                   10                  15      


Leu Gly Gly Phe Ser Asp Phe His Glu Met Gln Lys Glu Val Trp Gln 
            20                  25                  30          


Leu Gln Arg Gln Tyr Arg Glu Ile Leu Asn Lys Thr Ile Gln Ile Ala 
        35                  40                  45              


Leu His Trp Asp Tyr Val Ser Ala Gln Gln Phe Gly Glu Ser Gly Thr 
    50                  55                  60                  


Tyr Leu Asp Ile Arg Glu Glu Thr Gly Tyr Lys Thr Leu Asp Gly Tyr 
65                  70                  75                  80  


Ile Tyr Asn Cys Leu Lys Gly Ala Tyr Ser Glu Met Ala Ser Ala Asn 
                85                  90                  95      


Leu Asn Ala Ala Val Gln Lys Ala Trp Lys Lys Tyr Lys Asn Ser Lys 
            100                 105                 110         


Thr Gln Val Leu Gln Gly Val Met Ser Leu Pro Ser Tyr Lys Ser Asp 
        115                 120                 125             


Gln Pro Ile Leu Ile Asp Lys Gly Asn Val Lys Leu Ser Ala Glu Glu 
    130                 135                 140                 


Asn Asn Gly Arg Ala Val Leu Thr Leu Phe Ser Arg Asn Tyr Arg Asp 
145                 150                 155                 160 


Thr Arg Gly Leu Lys Gly Asn Val Glu Phe Ser Val Leu Leu His Asp 
                165                 170                 175     


Gly Thr Gln Lys Ser Ile Phe Arg Asn Leu Ile Asp Lys Thr Tyr Ala 
            180                 185                 190         


Leu Gly Gln Cys Gln Leu Val Tyr Glu Arg Lys Lys Trp Phe Leu Leu 
        195                 200                 205             


Leu Thr Tyr Ser Phe Thr Pro Ala Gly His Ala Leu Asp Pro Glu Lys 
    210                 215                 220                 


Ile Leu Gly Val Asp Leu Gly Glu Cys Tyr Ala Leu Tyr Ala Ser Ser 
225                 230                 235                 240 


Cys Tyr Ala Pro Gly Ile Leu Lys Ile Glu Gly Gly Glu Ile Ala Glu 
                245                 250                 255     


Tyr Ala Leu Arg Leu Glu Lys Arg Lys Arg Ser Leu Gln Gln Gln Ala 
            260                 265                 270         


Arg Tyr Cys Gly Glu Gly Arg Ile Gly His Gly Thr Lys Thr Arg Val 
        275                 280                 285             


Gly Val Val Tyr Lys Ala Glu Asp Arg Ile Ala Ser Phe Arg Glu Thr 
    290                 295                 300                 


Ile Asn His Arg Tyr Ser Lys Glu Leu Val Asp Tyr Ala Val Ser Asn 
305                 310                 315                 320 


Gly Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Ala Ile Gln Lys Asp 
                325                 330                 335     


Leu Gly Phe Pro Lys Arg Leu Arg His Trp Thr Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Met Lys Ile Thr Asn Lys Ala Lys Glu His Gly Ile Ala Val Val Lys 
        355                 360                 365             


Ile Asp Pro Arg Tyr Thr Ser Gln Arg Cys Ser Lys Cys Gly His Ile 
    370                 375                 380                 


Asp Pro Ala Asn Arg Pro Arg Gln Glu Glu Phe Cys Cys Thr Ala Cys 
385                 390                 395                 400 


Gly Tyr Ala Cys Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ser Ile 
                405                 410                 415     


Lys Gly Ile Glu Lys Ile Ile Gln Lys Met Leu Ser Ala Lys Ala Asp 
            420                 425                 430         


<210> 114
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 114
Met Ser Lys Gly Met Leu Thr Lys Val Met Lys Tyr Thr Leu Arg Tyr 
1               5                   10                  15      


Val Gly Gly Cys Gly Asp Phe His Glu Met Gln Ser Ile Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Ala Val Leu Asn Lys Thr Ile Gln Ile Ala 
        35                  40                  45              


Phe Glu Trp Asp Tyr Arg Ser Arg Glu Ala Phe Gln Glu Thr Gly Glu 
    50                  55                  60                  


Tyr Leu Asp Val His Ala Glu Thr Gly Tyr Lys Arg Leu Asp Gly Tyr 
65                  70                  75                  80  


Ile Tyr Asn Cys Leu Lys Asn Glu Tyr Ala Asp Phe Ala Gly Lys Asn 
                85                  90                  95      


Leu Asn Ala Ala Ile Gln Thr Ala Trp Lys Lys Tyr Asn Gln Ser Lys 
            100                 105                 110         


Arg Asp Ile Gln Thr Gly Lys Met Ser Leu Pro Ser Tyr Arg Ser Asn 
        115                 120                 125             


Gln Pro Leu Ile Ile His Asn Asp Asn Val Met Ile Ser Gln Asp Met 
    130                 135                 140                 


Gln Ala Ala Pro Ser Val Arg Phe Thr Leu Leu Ser Leu Glu Tyr Lys 
145                 150                 155                 160 


Lys Ala His Asp Leu Asn Thr Asn Pro Thr Phe Glu Val Leu Ile Asn 
                165                 170                 175     


Asp Gly Thr Gln Arg Ala Ile Phe Glu Lys Val Arg Ser Gly Glu Tyr 
            180                 185                 190         


Lys Leu Gly Gln Cys Met Ile Gln Tyr Asp Lys Lys Lys Trp Phe Leu 
        195                 200                 205             


Leu Leu Thr Tyr Ser Phe Gln Pro Glu Lys Leu Thr Leu Asp Lys Asn 
    210                 215                 220                 


Lys Ile Leu Gly Val Asp Leu Gly Glu Thr Ile Val Ile Cys Ala Ser 
225                 230                 235                 240 


Ser Val Ser Glu Arg Gly Arg Phe Val Ile Asp Gly Gly Glu Ile Thr 
                245                 250                 255     


Arg Phe Ala Thr Gln Ile Glu Ala Arg Lys Arg Ser Gln Gln His Gln 
            260                 265                 270         


Ala Ala Tyr Cys Gly Glu Gly Arg Ile Gly His Gly Thr Lys Thr Arg 
        275                 280                 285             


Val Asp Ala Val Tyr Lys Thr Glu Asp Arg Ile Ala Asn Phe Arg Asp 
    290                 295                 300                 


Thr Ile Asn His Arg Tyr Ser Arg Ala Leu Val Asn Tyr Ala Val Lys 
305                 310                 315                 320 


His Gly Phe Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Ser 
                325                 330                 335     


Ser Asp Asp Phe Pro Lys Phe Leu Arg His Trp Thr Tyr Tyr Asp Leu 
            340                 345                 350         


Gln Ser Lys Ile Glu Ser Lys Ala Lys Glu Arg Gly Ile Ala Val Val 
        355                 360                 365             


Lys Val Asn Pro Arg Phe Thr Ser Arg Arg Cys Ser Lys Cys Gly Tyr 
    370                 375                 380                 


Ile Asp Glu Gly Asn Arg Lys Asp Gln Ala His Phe Cys Cys Leu Ser 
385                 390                 395                 400 


Cys Gly Phe Arg Ala Asn Ala Asp Phe Asn Ala Ser Gln Asn Leu Ser 
                405                 410                 415     


Ile Lys Gly Ile Asp Lys Ile Ile Glu Lys Glu Tyr Asn Ala Asn Ser 
            420                 425                 430         


Lys Gln Thr 
        435 


<210> 115
<211> 442
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 115
Met Gly Lys Pro Ile Thr Lys Thr Met Lys Tyr Gln Ile His Tyr Ile 
1               5                   10                  15      


Asp Gly Cys Gly Asp Phe His Asn Met Gln Lys Glu Leu Trp Asp Leu 
            20                  25                  30          


Gln Arg Ile Val Arg Gln Ile Leu Asn Lys Thr Ile Asn Glu Ser Tyr 
        35                  40                  45              


Leu Trp Phe Val Arg Ser Glu Gln Tyr Tyr Arg Asp Thr Gly Glu Asn 
    50                  55                  60                  


Leu Ser Val Glu Glu Gln Thr Gly Tyr Lys Thr Leu Asp Gly His Ile 
65                  70                  75                  80  


Tyr Asn Leu Leu Lys Gln Glu Tyr Thr Gln Lys Leu Val Ser Asn Ser 
                85                  90                  95      


Leu Asn Ala Ser Ile Gln Ala Ala Tyr Lys Lys Met Lys Asp Ser Arg 
            100                 105                 110         


Arg Asp Val Met Ile Gly Thr Met Ser Leu Pro Ser Tyr Arg Ser Asp 
        115                 120                 125             


Gln Pro Ile Ile Ile Tyr Asn Lys Asn Ile Lys Phe Ser Ser His Pro 
    130                 135                 140                 


Glu His Gly Phe Val Val Asp Cys Ser Leu Phe Ser Asp Ala Tyr Lys 
145                 150                 155                 160 


Lys Ser Gln Gly Tyr Glu Lys Ser Val Lys Phe Gln Val Ser Val Asp 
                165                 170                 175     


Asp Asn Thr Gln Arg Ser Ile Phe Glu Asn Ile Leu Thr Gly Asn Tyr 
            180                 185                 190         


Lys His Gly Gln Cys Ser Ile Val Tyr Glu Lys Lys Lys Trp Phe Leu 
        195                 200                 205             


Leu Leu Thr Tyr Ser Phe Val Pro Glu Glu Thr Lys Leu Asp Pro Asp 
    210                 215                 220                 


Lys Ile Leu Gly Val Asp Val Gly Val Val Tyr Ala Leu Tyr Ala Ser 
225                 230                 235                 240 


Ser Lys Gly Asn His Gly Thr Phe Lys Ile Lys Gly Asp Glu Ala Ile 
                245                 250                 255     


Thr Phe Ile Gln Arg Val Glu Ala Arg Lys His Ser Arg Gln Leu Gln 
            260                 265                 270         


Gly Thr Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Thr Lys Thr Arg 
        275                 280                 285             


Val Gln Pro Val Tyr Asn Glu Arg Ala Leu Ile Ser Asn Phe Gln Asp 
    290                 295                 300                 


Thr Ile Asn His Arg Tyr Ser Lys Ala Leu Ile Asp Tyr Ala Lys Lys 
305                 310                 315                 320 


Asn Gly Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Glu 
                325                 330                 335     


Val Gln Gln Tyr Pro Lys Tyr Leu Gln His Trp Thr Tyr Tyr Asp Leu 
            340                 345                 350         


Gln Leu Lys Ile Gln Tyr Lys Ala Lys Glu Ala Gly Ile Gly Phe Val 
        355                 360                 365             


Lys Val Thr Pro Lys Tyr Thr Ser Gln Arg Cys Ser His Cys Gly Asn 
    370                 375                 380                 


Ile Asp Glu Ala Asn Arg Pro Lys Gln Asp Val Phe Arg Cys Thr Val 
385                 390                 395                 400 


Cys Gly Tyr Glu Arg Asn Ala Asp Tyr Asn Ala Ser Gln Asn Leu Ser 
                405                 410                 415     


Ile Lys Gly Ile Asp Arg Ile Ile Asp Asp Gln Leu Lys Gln Met Asn 
            420                 425                 430         


Lys Ala Asn Pro Lys Lys Thr Glu Asn Ala 
        435                 440         


<210> 116
<211> 435
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 116
Met Ser Gly Gly Ala Ile Thr Lys Val Met Lys Tyr Asp Leu Thr Tyr 
1               5                   10                  15      


Lys Asp Gly Tyr Gly Asn Phe Lys Asp Met Gln Glu Ala Val Trp Lys 
            20                  25                  30          


Leu Ile Arg Asp Thr Arg Thr Ile Leu Asn Glu Thr Ile Lys Ile Ala 
        35                  40                  45              


Tyr His Trp Asp Tyr Leu Asn Glu Lys Ser Lys Arg Glu Thr Gly Glu 
    50                  55                  60                  


His Leu Asp Leu Leu Glu Glu Thr Gly Tyr Lys Arg Leu Asp Gly Tyr 
65                  70                  75                  80  


Ile Tyr Asp Asp Leu Lys Asp Arg Phe Pro Asp Phe Ala Ser Ser Asn 
                85                  90                  95      


Leu Asn Ala Ala Ile Gln Thr Ala Trp Lys Lys Tyr Lys Gln Ser Gln 
            100                 105                 110         


Lys Asp Val Tyr Ile Gly Lys Met Thr Leu Pro Ser Tyr Lys Ser Asp 
        115                 120                 125             


Gln Pro Leu Pro Ile Asn Lys Gln Ser Ile Lys Ile Tyr Asp Glu Glu 
    130                 135                 140                 


Arg Glu His Ile Val Glu Leu Asn Leu Phe Ser Thr Lys His Lys Lys 
145                 150                 155                 160 


Glu His Gly Leu Ala Ser Asn Val Arg Phe Arg Ile Asn Leu His Asp 
                165                 170                 175     


Asn Thr Gln His Ala Ile Tyr Glu Arg Val Leu Ser Gly Glu Tyr Thr 
            180                 185                 190         


Leu Gly Gln Cys Gln Leu Leu Tyr Asp Arg Pro Lys Trp Phe Phe Ile 
        195                 200                 205             


Leu Thr Tyr Ser Phe Lys Pro Ala Gln Asn Lys Leu Asp Pro Asp Lys 
    210                 215                 220                 


Ile Leu Gly Val Asp Met Gly Glu Thr Cys Ala Leu Tyr Ala Ser Thr 
225                 230                 235                 240 


Phe Gly Glu Gln Gly Ser Phe Val Ile Asn Gly Gly Glu Val Ser Glu 
                245                 250                 255     


Tyr Ala Lys Arg Glu Glu Ala Arg Lys Arg Ser Leu Gln Lys Gln Ala 
            260                 265                 270         


Ala Val Cys Gly Glu Gly Arg Ile Gly His Gly Thr Lys Thr Arg Val 
        275                 280                 285             


Ser Ser Val Tyr Lys Glu Gln Glu Arg Ile Ser Asn Phe Arg Asp Thr 
    290                 295                 300                 


Ile Asn His Arg Tyr Ser Lys Ala Leu Ile Glu Tyr Ala Val Lys Asn 
305                 310                 315                 320 


Gly Cys Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Arg Gln Ser 
                325                 330                 335     


Thr Asp Phe Pro Lys Phe Leu Arg His Trp Thr Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Gln Lys Ile Lys Thr Lys Ala Lys Glu Thr Gly Ile Ala Val Ser Met 
        355                 360                 365             


Ile Asp Pro Arg Tyr Thr Ser Gln Arg Cys Ser Arg Cys Gly His Ile 
    370                 375                 380                 


Asp Lys Ala Asn Arg Lys Asp Gln Ala His Phe His Cys Leu Lys Cys 
385                 390                 395                 400 


Gly Tyr Ser Cys Asn Ala Asp Phe Asn Ala Ser Gln Asn Ile Ser Ile 
                405                 410                 415     


Arg Gly Ile Asp Lys Ile Ile Gln Lys Glu Leu Gly Ala Lys Ala Lys 
            420                 425                 430         


Gln Thr Asp 
        435 


<210> 117
<211> 431
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 117
Met Lys Glu Ile Ala Lys Val Met Lys Tyr Gln Leu Ile Tyr Leu Asp 
1               5                   10                  15      


Gly Gly Gly Asp Phe Tyr Glu Leu Gln Gln Thr Leu Trp Asp Leu Gln 
            20                  25                  30          


Arg Gln Thr Arg Glu Ile Leu Asn Lys Thr Ile Gln Ser Met Tyr Leu 
        35                  40                  45              


Ala Thr Ala Thr Asn Thr Ala Phe Glu Glu Asn Ala Leu Tyr His Arg 
    50                  55                  60                  


Phe Gly Ala Glu Tyr Pro Met Met Ala Ala Leu Asn Val Asn Ala Thr 
65                  70                  75                  80  


Leu Arg Thr Ala Lys Lys Arg Tyr Thr Ser Thr Ile Lys Glu Thr Leu 
                85                  90                  95      


Arg Gly Thr Met Ser Leu Pro Ser Tyr Lys Arg Asp Gln Pro Ile Leu 
            100                 105                 110         


Leu His Asn Gln Thr Ile His Leu Ala Leu Glu Asp Gly Gln Tyr Ser 
        115                 120                 125             


Ala Leu Phe Ser Val Tyr Ser Glu Lys Phe Gln Lys Ala His Glu Gly 
    130                 135                 140                 


Val Ala Arg Pro Arg Phe Ala Leu Met Ala Arg Asp Gly Thr Gln Arg 
145                 150                 155                 160 


Ala Ile Leu Asp Arg Leu Leu Asp Gly Ser Tyr Arg Leu Gly Gln Ser 
                165                 170                 175     


Gln Met Thr Tyr Glu Gln Lys Lys Trp Phe Leu Ser Leu Thr Tyr Lys 
            180                 185                 190         


Phe Val Pro Glu Val Arg Glu Leu Asp Lys Ser Lys Ile Leu Gly Val 
        195                 200                 205             


Asp Leu Gly Cys Val Tyr Ala Ile Tyr Ala Ser Ser Met Gln Gln Lys 
    210                 215                 220                 


Gly Ile Phe Lys Ile Ser Gly Asp Glu Ile Thr Glu Phe Glu Lys Arg 
225                 230                 235                 240 


Gln Ala Ala Met Gln Asn Arg Glu Pro Val Ser Thr Leu Glu Arg Val 
                245                 250                 255     


Glu Gln Leu Glu Gln Arg Arg Trp Gln Lys Gln Gln Gln Ala Arg Tyr 
            260                 265                 270         


Cys Gly Glu Gly Arg Val Gly His Gly Thr Gly Thr Arg Val Ala Pro 
        275                 280                 285             


Ala Tyr Arg Asp Ala Asp Lys Ile Ala Arg Phe Arg Asp Thr Ile Asn 
    290                 295                 300                 


His Arg Tyr Ser Lys Ala Leu Val Glu Tyr Ala Glu Lys Asn Gly Phe 
305                 310                 315                 320 


Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Glu Asp Thr Gly 
                325                 330                 335     


Phe Pro Lys Arg Leu Arg His Trp Thr Tyr Phe Asp Leu Gln Thr Lys 
            340                 345                 350         


Ile Gln Tyr Lys Ala Ala Glu Arg Gly Ile Thr Val Val Lys Ile Asp 
        355                 360                 365             


Pro Gln Tyr Thr Ser Gln Arg Cys Ser Arg Cys Gly Tyr Ile Asp Lys 
    370                 375                 380                 


Ala Asn Arg Ala Ser Gln Glu Lys Phe Leu Cys Gln Ser Cys Gly Phe 
385                 390                 395                 400 


Glu Ala Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ser Val Glu Lys 
                405                 410                 415     


Ile Asp Lys Leu Ile Ala Lys Asp Lys Lys Lys Leu Ala Arg Thr 
            420                 425                 430     


<210> 118
<211> 436
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 118
Met Gly Gln Val Thr Lys Val Met Arg Tyr Gln Leu Ile Tyr Gln Asp 
1               5                   10                  15      


Gly Gly Gly Asp Phe Tyr Thr Val Gln Gln Glu Leu Trp Glu Leu Gln 
            20                  25                  30          


Arg Gln Thr Arg Glu Ile Leu Asn Lys Thr Ile Gln Thr Met Tyr Leu 
        35                  40                  45              


Ala Asp Ala Asn Lys Glu Lys Phe Asp Asn Ala Ala Glu Arg Thr Leu 
    50                  55                  60                  


Asn Arg Arg Phe Cys Val Asp His Pro Asp Met Tyr Thr Lys Thr Val 
65                  70                  75                  80  


Thr Ala Thr Leu Arg Lys Ala Lys Ala Lys Tyr Asn Ala Ser Gln Lys 
                85                  90                  95      


Glu Ile Leu Ala Gly Arg Met Ser Leu Pro Ser Tyr Lys Arg Asp Gln 
            100                 105                 110         


Pro Ile Leu Leu Asn Pro Gln Gly Phe Lys Ile Glu Glu Glu Ser Asp 
        115                 120                 125             


Ser Phe Phe Ala Ala Ile Ala Val Phe Ser Asp Lys Tyr Lys Asn Lys 
    130                 135                 140                 


His Pro Asp Val Asp Val Lys Arg Leu Arg Phe Arg Leu Val Val Lys 
145                 150                 155                 160 


Asp Gly Thr Gln Arg Ala Ile Ile Arg Arg Val Ile Ser Gly Glu Tyr 
                165                 170                 175     


Lys Leu Gly Arg Ser Gln Leu Leu Tyr Ser Lys Lys Lys Trp Phe Leu 
            180                 185                 190         


Asn Val Thr Tyr Ser Phe Glu Pro Ala Glu Lys Lys Val Asp Pro Asp 
        195                 200                 205             


Lys Ile Leu Gly Val Asp Leu Gly Cys Val Tyr Ala Ile Tyr Ala Ser 
    210                 215                 220                 


Ser Phe Gly Ser Pro Gly Val Phe Lys Ile Ser Gly Asp Glu Val Ser 
225                 230                 235                 240 


Ser Phe Glu Arg Lys Gln Ala Ala Ile Gln Asn Arg Ser Pro Lys Ser 
                245                 250                 255     


Thr Leu Glu Arg Val Glu Lys Ile Glu Glu Arg His Lys Gln Lys Gln 
            260                 265                 270         


Gln Gln Ala Arg Tyr Cys Gly Glu Gly Arg Ile Gly His Gly Thr Lys 
        275                 280                 285             


Thr Arg Ile Ala Pro Val Tyr Gln Asp Glu Asp Lys Ile Ala Arg Phe 
    290                 295                 300                 


Arg Asp Thr Val Asn His Arg Tyr Ser Lys Ala Leu Ile Asp Tyr Ala 
305                 310                 315                 320 


Glu Lys Asn Gly Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile 
                325                 330                 335     


Lys Ser Ala Thr Gly Phe Pro Lys Arg Leu Lys His Trp Thr Tyr Tyr 
            340                 345                 350         


Asp Leu Gln Thr Lys Ile Glu Tyr Lys Ala Glu Glu Arg Gly Ile Lys 
        355                 360                 365             


Val Val Lys Ile Asp Pro Arg Tyr Thr Ser Gln Arg Cys Ser Arg Cys 
    370                 375                 380                 


Gly Tyr Ile Asp Ser Gly Asn Arg Lys Ser Gln Ala Glu Phe Cys Cys 
385                 390                 395                 400 


Met Ala Cys Gly Phe Ser Cys Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
                405                 410                 415     


Ile Ser Ile Gly Gly Ile Ala Lys Ile Ile Ala Asp Lys Arg Lys Glu 
            420                 425                 430         


Ala Asp Ala Lys 
        435     


<210> 119
<211> 368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 119
Tyr Leu Asp Ile Arg Glu Glu Thr Gly Tyr Lys Thr Leu Asp Gly Tyr 
1               5                   10                  15      


Ile Tyr Asn Cys Leu Lys Gly Ala Tyr Ser Glu Met Ala Ser Ala Asn 
            20                  25                  30          


Leu Asn Ala Ala Val Gln Lys Ala Trp Lys Lys Tyr Lys Asn Ser Lys 
        35                  40                  45              


Thr Gln Val Leu Gln Gly Val Met Ser Leu Pro Ser Tyr Lys Ser Asp 
    50                  55                  60                  


Gln Pro Ile Leu Ile Asp Lys Gly Asn Val Lys Leu Ser Ala Glu Glu 
65                  70                  75                  80  


Asn Asn Gly Arg Ala Val Leu Thr Leu Phe Ser Arg Asn Tyr Arg Asp 
                85                  90                  95      


Thr Arg Gly Leu Lys Gly Asn Val Glu Phe Ser Val Leu Leu His Asp 
            100                 105                 110         


Gly Thr Gln Lys Ser Ile Phe Arg Asn Leu Ile Asp Lys Thr Tyr Ala 
        115                 120                 125             


Leu Gly Gln Cys Gln Leu Val Tyr Glu Arg Lys Lys Trp Phe Leu Leu 
    130                 135                 140                 


Leu Thr Tyr Ser Phe Thr Pro Ala Gly His Ala Leu Asp Pro Glu Lys 
145                 150                 155                 160 


Ile Leu Gly Val Asp Leu Gly Glu Cys Tyr Ala Leu Tyr Ala Ser Ser 
                165                 170                 175     


Cys Tyr Ala Pro Gly Ile Leu Lys Ile Glu Gly Gly Glu Ile Ala Glu 
            180                 185                 190         


Tyr Ala Leu Arg Leu Glu Lys Arg Lys Arg Ser Leu Gln Gln Gln Ala 
        195                 200                 205             


Arg Tyr Cys Gly Glu Gly Arg Ile Gly His Gly Thr Lys Thr Arg Val 
    210                 215                 220                 


Gly Val Val Tyr Lys Ala Glu Asp Arg Ile Ala Ser Phe Arg Glu Thr 
225                 230                 235                 240 


Ile Asn His Arg Tyr Ser Lys Glu Leu Val Asp Tyr Ala Val Ser Asn 
                245                 250                 255     


Gly Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Ala Ile Gln Lys Asp 
            260                 265                 270         


Leu Gly Phe Pro Lys Arg Leu Arg His Trp Thr Tyr Tyr Asp Leu Gln 
        275                 280                 285             


Met Lys Ile Thr Asn Lys Ala Lys Glu His Gly Ile Ala Val Val Lys 
    290                 295                 300                 


Ile Asp Pro Arg Tyr Thr Ser Gln Arg Cys Ser Lys Cys Gly His Ile 
305                 310                 315                 320 


Asp Pro Ala Asn Arg Pro Arg Gln Glu Glu Phe Cys Cys Thr Ala Cys 
                325                 330                 335     


Gly Tyr Ala Cys Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ser Ile 
            340                 345                 350         


Lys Gly Ile Glu Lys Ile Ile Gln Lys Met Leu Ser Ala Lys Ala Asp 
        355                 360                 365             


<210> 120
<211> 437
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 120
Met Ala Glu Lys Thr Ile Val Lys Val Met Lys Phe Glu Leu Arg Tyr 
1               5                   10                  15      


Ile Asp Gly Ala Gly Glu Phe Ser Glu Met Gln Lys His Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Glu Val Leu Asn Lys Thr Ile Gln Met Gly 
        35                  40                  45              


Tyr Ala Leu Glu Cys Lys Arg Phe Ala His His Asp Lys Thr Gly Gln 
    50                  55                  60                  


Trp Leu Asp Asp Lys Glu Leu Thr Gly Ser Lys Tyr Lys Ala Val Ala 
65                  70                  75                  80  


Asp Tyr Ile Asn Ala Glu Leu Lys Glu Asp Tyr Asn Ile Phe Tyr Ser 
                85                  90                  95      


Asp Cys Arg Asn Ser Thr Val Arg Lys Ala Tyr Lys Lys Phe Lys Asp 
            100                 105                 110         


Ala Lys Asn Lys Ile Phe Ser Gly Glu Met Ser Leu Pro Ser Tyr Arg 
        115                 120                 125             


Ser Asn Gln Pro Ile Ile Ile His Asn Arg Asn Val Ile Ile Arg Gly 
    130                 135                 140                 


Asn Ala Glu Ser Ala Leu Val Gly Leu Lys Val Phe Ser Asp Gly Phe 
145                 150                 155                 160 


Lys Ala Leu His Gly Phe Pro Ala Ala Val Asn Phe Lys Leu Cys Val 
                165                 170                 175     


Lys Asp Gly Thr Gln Arg Ala Ile Ile Glu Asn Val Ile Ser Glu Ile 
            180                 185                 190         


Tyr Lys Ile Ser Glu Ser Gln Leu Ile Tyr Asp Asn Lys Lys Trp Phe 
        195                 200                 205             


Leu Ile Leu Ala Tyr Arg Phe Thr Gln Lys Lys Asn Asp Leu Asn Pro 
    210                 215                 220                 


Asp Lys Ile Leu Gly Val Asp Leu Gly Val Lys Phe Ala Val Tyr Ala 
225                 230                 235                 240 


Ser Ser Ile Gly Glu Tyr Gly Ser Phe Arg Ile Lys Gly Gly Glu Val 
                245                 250                 255     


Thr Glu Phe Ile Lys Arg Leu Glu Lys Arg Lys Lys Ser Leu Gln Asn 
            260                 265                 270         


Gln Ala Thr Val Cys Gly Asp Gly Arg Ile Gly His Gly Thr Lys Thr 
        275                 280                 285             


Arg Val Ala Asp Val Tyr Lys Ala Arg Asp Lys Ile Ser Asn Phe Gln 
    290                 295                 300                 


Asp Thr Ile Asn His Arg Tyr Ser Arg Ala Ile Val Asp Tyr Ala Arg 
305                 310                 315                 320 


Lys Asn Gly Tyr Gly Thr Ile Gln Leu Glu Lys Leu Asp Asn Ser Ile 
                325                 330                 335     


Glu Lys Lys Gly Asp Tyr Ser Pro Val Leu Val His Trp Thr Tyr Tyr 
            340                 345                 350         


Asp Leu Arg Thr Lys Met Glu Tyr Lys Ala Ala Glu Tyr Gly Ile Lys 
        355                 360                 365             


Val Ile Ala Val Glu Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys 
    370                 375                 380                 


Gly Tyr Ile Ser Ser Glu Asn Arg Lys Thr Gln Glu Ser Phe Glu Cys 
385                 390                 395                 400 


Ile Lys Cys Gly Tyr Lys Cys Asn Ala Asp Phe Asn Ala Ser Gln Asn 
                405                 410                 415     


Leu Ser Val Arg Asp Ile Asp Arg Ile Ile Asp Glu Tyr Leu Gly Ala 
            420                 425                 430         


Asn Pro Glu Leu Thr 
        435         


<210> 121
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 121
Val Val Asn Val Ala Lys Gly Ala Leu Ser Lys Val Met Lys Phe Glu 
1               5                   10                  15      


Leu Ser Tyr Leu Asp Gly Cys Gly Asp Phe Gln Asn Met Gln Lys Glu 
            20                  25                  30          


Leu Trp Thr Leu Gln Arg Gln Thr Arg Glu Ile Leu Asn Arg Thr Ile 
        35                  40                  45              


Gln Ile Ala Tyr His Trp Asp Tyr Thr Asp Arg Glu His Phe Lys Lys 
    50                  55                  60                  


Thr Gly Gln His Leu Asp Val Lys Ser Glu Thr Gly Tyr Lys Arg Leu 
65                  70                  75                  80  


Asp Gly Tyr Ile Tyr Asp Glu Leu Lys Glu Thr Val Gln Asn Phe Ala 
                85                  90                  95      


Ser Val Asn Val Asn Ala Thr Ile Gln Lys Ala Trp Ala Lys Tyr Lys 
            100                 105                 110         


Ser Ser Lys Thr Asp Val Leu Arg Gly Asp Met Ser Leu Pro Ser Tyr 
        115                 120                 125             


Lys Ser Asp Gln Pro Leu Val Leu His Ala Gln Ser Ile Lys Leu Ser 
    130                 135                 140                 


Glu Asp Lys Asp Gly Pro Val Leu Gln Val Thr Leu Phe Ser Asn Ala 
145                 150                 155                 160 


His Lys Lys Ala Cys Asp Tyr Ser Asn Val Arg Phe Ala Phe Arg Leu 
                165                 170                 175     


His Asp Ala Thr Gln Arg Ala Ile Phe Lys Asn Val Leu Ser Gly Glu 
            180                 185                 190         


Tyr Gly Leu Gly Gln Ser Gln Ile Val Tyr Lys Arg Pro Lys Trp Phe 
        195                 200                 205             


Leu Tyr Leu Thr Tyr Asn Phe Ser Pro Glu Gln His Gly Leu Asp Pro 
    210                 215                 220                 


Asp Lys Ile Leu Gly Val Asp Leu Gly Glu Ser Ile Ala Leu Tyr Ala 
225                 230                 235                 240 


Ser Ser Leu Gly Asp Tyr Gly Ser Leu Arg Ile Glu Gly Gly Glu Val 
                245                 250                 255     


Thr Ala Phe Ala Lys Gln Leu Glu Ala Arg Lys Arg Ser Leu Gln Lys 
            260                 265                 270         


Gln Ala Ala His Cys Gly Glu Gly Arg Val Gly His Gly Thr Arg Ala 
        275                 280                 285             


Arg Val Ser Asp Val Tyr Lys Ala Glu Asp Lys Ile Ala Asn Phe Arg 
    290                 295                 300                 


Asn Thr Val Asn His Arg Tyr Ser Lys Lys Leu Ile Glu Tyr Ala Ile 
305                 310                 315                 320 


Gln Asn Arg Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys 
                325                 330                 335     


Gln Asp Thr Gly Phe Pro Lys Phe Leu Gln His Trp Thr Tyr Tyr Asp 
            340                 345                 350         


Leu Gln Gln Lys Ile Glu Ala Lys Ala Lys Glu Asn Gly Ile Asn Phe 
        355                 360                 365             


Ile Lys Val Asp Pro Ser Tyr Thr Ser Gln Arg Cys Ser Lys Cys Gly 
    370                 375                 380                 


Asn Ile Asp Ser Asp Asn Arg Pro Ser Gln Ala Val Phe Cys Cys Thr 
385                 390                 395                 400 


Lys Cys Gly Phe Arg Ala Asn Ala Asp Phe Asn Ala Ser Gln Asn Leu 
                405                 410                 415     


Ser Ile Pro Glu Ile Asp Lys Ile Ile Lys Lys Glu Arg Gly Ala Asn 
            420                 425                 430         


Thr Lys 
        


<210> 122
<211> 455
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 122
Met Ala Lys Lys Gly Thr Asn Arg Lys Lys Met Ile Val Lys Val Met 
1               5                   10                  15      


Lys Tyr Glu Leu Lys Tyr Glu Lys Gly Cys Ala Asp Phe Asn Glu Met 
            20                  25                  30          


Gln Asn Glu Leu Trp Lys Leu Gln Arg Gln Thr Arg Glu Val Met Asn 
        35                  40                  45              


Arg Thr Val Gln Leu Cys Tyr His Trp Asn Tyr Val Gln Ala Asp Tyr 
    50                  55                  60                  


Cys Lys Gln His Gly Cys Ala His Arg Asp Val Lys Pro Cys Asp Val 
65                  70                  75                  80  


Tyr Glu Thr Asn Ala Thr Ser Leu Asp Gly Tyr Ile Tyr Gln Leu Phe 
                85                  90                  95      


Lys Asp Glu Tyr Pro Asn Phe Leu Met Ala Asn Leu Ile Ala Thr Leu 
            100                 105                 110         


Arg Lys Ala His Gln Lys Tyr Asp Ala Leu Leu Pro Asp Ile Gln Glu 
        115                 120                 125             


Gly Asn Ser Ser Ile Pro Ser Phe Lys Lys Asp Gln Pro Leu Ile Phe 
    130                 135                 140                 


Ser Lys Glu Ala Ile His Leu Pro Glu Cys Leu Ser Asp Lys Arg Gln 
145                 150                 155                 160 


Ile Thr Leu Phe Cys Phe Ser Lys Pro Tyr Lys Ser Ala His Pro Thr 
                165                 170                 175     


Leu Asp Lys Ile Thr Phe Ala Val Arg Ala His Ser Ala Ser Glu Lys 
            180                 185                 190         


Ser Ile Phe Asp Asn Ile Ile Asn Gly Lys Tyr Ala Leu Gly Thr Ser 
        195                 200                 205             


Gln Leu Val Tyr Glu Lys Lys Lys Trp Phe Phe Leu Leu Ser Tyr Lys 
    210                 215                 220                 


Phe Thr Pro Glu Ser Val Asp Val Asn Pro Glu Lys Val Leu Gly Val 
225                 230                 235                 240 


Asp Leu Gly Val Val Asn Ala Leu Cys Ala Gly Ser Val Glu Asn Pro 
                245                 250                 255     


His Asp Ser Leu Phe Ile Lys Gly Thr Glu Ala Ile Glu Gln Ile Arg 
            260                 265                 270         


Arg Leu Glu Ala Arg Lys Arg Asp Leu Gln Lys Gln Ala Arg Tyr Pro 
        275                 280                 285             


Gly Asp Gly Arg Ile Gly His Gly Thr Lys Thr Arg Val Ser Pro Val 
    290                 295                 300                 


Tyr Gln Thr Arg Asp Ala Ile Ala Arg Met Gln Asp Thr Leu Asn His 
305                 310                 315                 320 


Arg Trp Ser Arg Ala Leu Ile Asp Phe Ala Cys Lys Lys Gly Tyr Gly 
                325                 330                 335     


Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Ala Met Glu Ser Glu 
            340                 345                 350         


Lys Pro Tyr Leu Lys His Trp Thr Tyr Phe Asp Leu Gln Ser Lys Ile 
        355                 360                 365             


Ile Tyr Lys Ala Glu Glu Lys Gly Ile Arg Val Val Lys Val Asn Pro 
    370                 375                 380                 


Lys Cys Thr Ser Arg Arg Cys Ser Ala Cys Gly Tyr Ile Ser Lys Glu 
385                 390                 395                 400 


Asn Arg Lys Asn Gln Ala Glu Phe Leu Cys Val Asn Cys Gly Tyr His 
                405                 410                 415     


His Asn Ala Asp Tyr Asn Ala Ala Gln Asn Leu Ser Ile Pro Gln Ile 
            420                 425                 430         


Asp Arg Leu Ile Glu Lys Gln Leu Lys Glu Gln Glu Ser Glu Glu Ser 
        435                 440                 445             


Glu Ala Gly Ala Asn Pro Lys 
    450                 455 


<210> 123
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 123
Met Thr Glu Arg His Asp Asn Glu Ser Ser Lys Ile Lys Ala Glu Val 
1               5                   10                  15      


Ser Leu Leu Asn Ser Ser Val Pro Asp Phe Glu Lys Lys Arg His Val 
            20                  25                  30          


Lys Val Leu Lys Leu His Ile Leu Lys Pro Ala Gly Asp Met Lys Trp 
        35                  40                  45              


Asp Glu Leu Gly Ala Leu Leu Arg Asp Ala Arg Tyr Arg Val Phe Arg 
    50                  55                  60                  


Leu Ala Asn Leu Ala Ile Ser Glu Ala Tyr Leu Asp Phe His Lys Trp 
65                  70                  75                  80  


Arg Ser Gly Gly Asn Glu Gln Pro Lys Leu Lys Ile Ser Gln Leu Asn 
                85                  90                  95      


Arg Asn Leu Arg Ser Met Leu Glu Asp Glu Val Thr Gly Lys Gln Thr 
            100                 105                 110         


Lys Met Ile Lys Ser Asp Arg Tyr Ser Lys Ser Gly Ala Leu Pro Asp 
        115                 120                 125             


Ser Ile Val Ser Pro Leu Ser Met Tyr Lys Leu Gly Gly Leu Thr Ser 
    130                 135                 140                 


Lys Ser Lys Trp Ser Glu Val Leu Arg Gly Lys Ser Ser Leu Pro Thr 
145                 150                 155                 160 


Phe Lys Leu Asn Met Ala Ile Pro Val Arg Cys Asp Lys Pro Gly Asp 
                165                 170                 175     


Arg Arg Ile Glu Arg Thr Lys Asn Gly Asp Ala Glu Val Glu Leu Arg 
            180                 185                 190         


Ile Cys Leu Gln Pro Tyr Pro Arg Val Ile Ile Ala Thr Gly Arg Asn 
        195                 200                 205             


Ser Leu Gly Asp Gly Gln Arg Ala Ile Leu Asp Arg Leu Leu Asp Asn 
    210                 215                 220                 


Thr Lys Tyr Ser Glu Gln Gly Tyr Arg Gln Arg Cys Phe Glu Ile Lys 
225                 230                 235                 240 


Glu Asp Gln Arg Ser Gly Lys Trp His Leu Phe Val Thr Tyr Asp Phe 
                245                 250                 255     


Pro Ala Ile Glu Pro Ala Lys Asn Leu Ser Arg Glu Arg Ile Val Gly 
            260                 265                 270         


Val Asp Leu Gly Ala Ala Cys Pro Leu Tyr Ala Ala Ile Asn Thr Gly 
        275                 280                 285             


His Ala Arg Leu Gly Trp Lys His Phe Ser Pro Leu Ala Ala Arg Val 
    290                 295                 300                 


Arg Ala Leu Gln Asn Gln Thr Ile Arg Arg Arg Arg Gln Ile Leu Arg 
305                 310                 315                 320 


Gly Gly Lys Val Ser Leu Ser Glu Asp Ser Ala Arg Ser Gly His Gly 
                325                 330                 335     


Arg Lys Arg Lys Leu Lys Pro Ile Ser Lys Leu Glu Gly Lys Ile Asp 
            340                 345                 350         


Arg Ala Tyr Thr Thr Leu Asn His Gln Leu Ser Ala Thr Val Ile Lys 
        355                 360                 365             


Phe Ala Lys Asp Asn Gly Ala Gly Val Val Gln Met Glu Asp Leu Lys 
    370                 375                 380                 


Gly Leu Arg Glu Thr Leu Thr Gly Thr Phe Leu Gly Glu Arg Trp Arg 
385                 390                 395                 400 


Tyr Glu Glu Leu Gln Arg Phe Ile Arg Tyr Lys Ala Asp Glu Ala Gly 
                405                 410                 415     


Ile Glu Ile Arg Leu Val Asn Pro Gln Tyr Thr Ser Arg Arg Cys Ser 
            420                 425                 430         


Glu Cys Gly His Ile His Lys Asp Phe Thr Arg Glu Phe Arg Asp Lys 
        435                 440                 445             


Ser Arg Glu Gly Asn Lys Ser Val Arg Phe Leu Cys Pro Asp Cys Gly 
    450                 455                 460                 


Phe Thr Ala Asp Pro Asp Tyr Asn Ala Ala Arg Asn Leu Ala Ser Leu 
465                 470                 475                 480 


Asp Ile Ala Ala Ile Ile Glu Arg Gln Leu Glu Ile Gln Gly Leu Arg 
                485                 490                 495     


Lys His Asp Pro 
            500 


<210> 124
<211> 471
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 124
Met Lys Glu Lys Ser Lys Thr Leu Val Lys Val Ala Arg Leu Arg Ile 
1               5                   10                  15      


Leu Lys Pro Ala Gly Asp Met Lys Trp Ser Glu Leu Gly Glu Met Leu 
            20                  25                  30          


Arg Thr Val Arg Tyr Arg Val Phe Arg Leu Ala Asn Leu Ala Val Ser 
        35                  40                  45              


Glu Ala Tyr Leu Gly Phe His Met Tyr Arg Thr Asn Arg Ala Thr Glu 
    50                  55                  60                  


Phe Lys Ala Glu Thr Ile Gly Lys Leu Ser Arg Arg Leu Arg Glu Met 
65                  70                  75                  80  


Leu Ile Glu Glu Gly Val Asp Glu Lys Asp Leu Ser Arg Tyr Ser Gln 
                85                  90                  95      


Thr Gly Ala Val Pro Asp Thr Val Ala Gly Ala Leu Gly Gln Tyr Lys 
            100                 105                 110         


Ile Arg Gly Ile Thr Ser Pro Thr Lys Trp Arg Gln Val Val Arg Gly 
        115                 120                 125             


Gln Ala Ala Leu Pro Thr Phe Arg Asn Asp Met Ala Ile Pro Ile Arg 
    130                 135                 140                 


Cys Asp Lys Gln Tyr Gln Arg Arg Leu Glu Lys Thr Glu Ala Gly Glu 
145                 150                 155                 160 


Ile Glu Val Glu Leu Met Ile Cys Arg Lys Pro Tyr Pro Arg Ile Val 
                165                 170                 175     


Leu Gly Thr Ala Asp Leu Gly Pro Gly Gln Arg Ala Ile Leu Glu Arg 
            180                 185                 190         


Leu Leu Gln Asn Thr Asp Asn Ser Ala Asp Gly Tyr Arg Gln Arg Leu 
        195                 200                 205             


Phe Glu Ala Lys Gln Asp Thr Gln Thr Lys Lys Trp Trp Leu Tyr Val 
    210                 215                 220                 


Thr Tyr Asp Phe Pro Arg Leu Lys Glu Gly Lys Leu Asn Gln Glu Ile 
225                 230                 235                 240 


Val Val Gly Val Asp Leu Gly Phe Ser Ile Pro Leu Tyr Val Ala Leu 
                245                 250                 255     


Asn Ile Gly His Ala Arg Leu Gly Arg Arg His Phe Gln Ala Leu Gly 
            260                 265                 270         


Asn Arg Ile Arg Ser Leu Gln Arg Gln Val Leu Ala Arg Arg Arg Ser 
        275                 280                 285             


Ile Gln Arg Gly Gly Arg Val Asn Ile Ser His Ser Thr Ala Arg Ser 
    290                 295                 300                 


Gly His Gly Arg Lys Arg Lys Leu Leu Pro Thr Glu Lys Leu Arg Gly 
305                 310                 315                 320 


Arg Ile Glu Lys Ser Tyr Ser Thr Leu Asn His Gln Leu Ser Ala Ser 
                325                 330                 335     


Val Ile Asp Phe Ala Lys Asn His His Ala Gly Thr Ile Gln Ile Glu 
            340                 345                 350         


Asp Leu Ala Asn Leu Lys Glu Glu Leu Ala Gly Thr Phe Ile Gly Ala 
        355                 360                 365             


Arg Trp Arg Tyr His Gln Leu Gln Gln Phe Leu Lys Tyr Lys Ala Glu 
    370                 375                 380                 


Glu Ala Gly Ile Thr Leu Asn Gln Val Asn Pro Arg Tyr Thr Ser Arg 
385                 390                 395                 400 


Arg Cys Ser Glu Cys Gly Phe Ile Asn Ile Asp Phe Asp Arg Ala Phe 
                405                 410                 415     


Arg Asp Ala Gly Arg Thr Glu Gly Arg Val Thr Lys Phe Leu Cys Pro 
            420                 425                 430         


Glu Cys Gly Tyr Glu Ala Asp Pro Asp Tyr Asn Ala Ala Arg Asn Ile 
        435                 440                 445             


Ser Ile Leu Asp Ile Asp Lys Leu Ile Arg Val Gln Cys Lys Lys Gln 
    450                 455                 460                 


Gly Leu Thr Tyr Asp Ala His 
465                 470     


<210> 125
<211> 475
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 125
Met Pro Glu Arg Pro Lys Thr Val Asn Lys Val Ile Trp Phe Gln Ile 
1               5                   10                  15      


His Lys Pro Ala Gly Asp Met Thr Trp Lys Glu Leu Gly Asn Leu Leu 
            20                  25                  30          


Arg Glu Ala Arg Tyr Arg Val Phe Arg Leu Ala Asn Leu Ala Val Ser 
        35                  40                  45              


Glu Lys Tyr Leu Ser Phe His Met Trp Arg Thr Gly Gln Glu Tyr Lys 
    50                  55                  60                  


Ser Glu Thr Ile Gly Lys Leu Asn Arg Arg Leu Arg Glu Met Leu Ile 
65                  70                  75                  80  


Glu Glu Gly Val Glu Glu Glu Ser Gln Lys Arg Phe Ser Ala Thr Gly 
                85                  90                  95      


Ala Leu Pro Asp Thr Val Val Ser Thr Leu Ala Lys Gly Lys Leu Ala 
            100                 105                 110         


Ala Ile Thr Ser Lys Ser Lys Trp Lys Asp Val Val Asn Gly Lys Thr 
        115                 120                 125             


Ser Leu Pro Thr Phe Lys Leu Asn Met Ala Ile Pro Val Arg Cys Asp 
    130                 135                 140                 


Lys Ala Glu Gln Arg Arg Leu Arg Arg Thr Glu Ser Gly Asp Val Glu 
145                 150                 155                 160 


Leu Glu Leu Met Ile Cys Lys Gln Pro Tyr Pro Arg Val Val Leu Lys 
                165                 170                 175     


Thr Gly Lys Leu Lys Ser Gly Gln Arg Ala Ile Leu Asp Arg Leu Val 
            180                 185                 190         


Glu Asn Asn Asp Asn Ser Lys Glu Gly Tyr Ser Gln Arg Val Phe Glu 
        195                 200                 205             


Ile Lys Gln Val Glu Asn Asn Asp Gly Ser Lys Glu Trp Arg Leu Tyr 
    210                 215                 220                 


Ile Ser Tyr Thr Phe Pro Lys Lys Ala Val Glu Ala Asn Ala Asp Val 
225                 230                 235                 240 


Ala Val Gly Val Asp Ile Gly Phe Ser Val Pro Leu Val Ala Ala Val 
                245                 250                 255     


Asn Asn Gly Leu Glu Arg Leu Gly Tyr Asn Asp Phe Arg Ala Leu Asn 
            260                 265                 270         


Glu Arg Ile Arg Ser Leu Gln Arg Gln Val Leu Val Arg Arg Arg Ser 
        275                 280                 285             


Met Gln Ser Gly Gly Arg Asp Tyr Val Ser Thr Pro Thr Ala Arg Ser 
    290                 295                 300                 


Gly His Gly Arg Lys Arg Lys Leu Leu Pro Ile Gln Thr Leu Arg Lys 
305                 310                 315                 320 


Arg Trp Asp Asn Ala Tyr Thr Thr Leu Asn His Gln Leu Ser His Ala 
                325                 330                 335     


Val Val Ser Phe Ala Glu Asn His Gly Ala Ala Thr Ile Gln Ile Glu 
            340                 345                 350         


Asn Val Lys Ser Leu Lys Asp Glu Leu Arg Gly Thr Phe Leu Gly Gln 
        355                 360                 365             


Arg Trp Arg Tyr Phe Glu Leu Gln Gln Phe Leu Lys Tyr Lys Ala Asp 
    370                 375                 380                 


Glu Val Gly Ile Glu Leu Arg Glu Val Asn Ala Arg Tyr Thr Ser Arg 
385                 390                 395                 400 


Arg Cys Ser Glu Cys Gly Tyr Ile Asn Met Ala Phe Thr Arg Gln Ala 
                405                 410                 415     


Arg Asp Lys Gly Arg Val Asp Gly Lys Pro Met Glu Phe Val Cys Pro 
            420                 425                 430         


Glu Cys Gly Tyr Lys Ala His Pro Asp Tyr Asn Ala Ala Arg Asn Ile 
        435                 440                 445             


Ala Met Leu Asp Ile Glu Gln Lys Met Gln Val Gln Cys Lys Gln Gln 
    450                 455                 460                 


Gly Ile Thr Tyr Ala Asp Asp Ser Glu Val Leu 
465                 470                 475 


<210> 126
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 126
Met Thr Trp Pro Glu Leu Gly Asn Met Leu Arg Thr Val Arg Tyr Arg 
1               5                   10                  15      


Val Phe Arg Leu Ala Asn Leu Ala Val Ser Glu Ala Tyr Leu Gly Phe 
            20                  25                  30          


His Met Phe Arg Thr Lys Arg Ala Glu Glu Phe Lys Ala Glu Thr Met 
        35                  40                  45              


Gly Lys Leu Ser Arg Arg Leu Arg Glu Met Leu Ile Glu Glu Gly Val 
    50                  55                  60                  


Asp Glu Lys Asp Leu Ser Arg Tyr Ser Gln Thr Gly Ala Val Pro Asp 
65                  70                  75                  80  


Thr Val Ala Gly Ala Leu Ser Gln Tyr Lys Ile Arg Gly Ile Thr Ser 
                85                  90                  95      


Pro Thr Lys Trp Arg Gln Ile Val Arg Gly Gln Val Ala Leu Pro Thr 
            100                 105                 110         


Phe Arg Asn Thr Met Ser Ile Pro Val Arg Cys Asp Lys Leu Tyr Gln 
        115                 120                 125             


Arg Arg Leu Glu Gln Gly Asp Ser Gly Glu Val Glu Val Glu Leu Met 
    130                 135                 140                 


Ile Cys Arg Asn Pro Tyr Pro Arg Val Val Leu Gly Thr Gly Asp Leu 
145                 150                 155                 160 


Asn Pro Gly Gln Gln Ala Ile Leu Glu Arg Leu Leu Gln Asn Thr Asp 
                165                 170                 175     


Asn Ser Ala Asp Gly Tyr Arg Gln Arg Leu Phe Glu Ile Lys Glu Asp 
            180                 185                 190         


Val Gln Thr Arg Lys Trp Trp Leu Tyr Val Thr Tyr Asp Phe Pro Lys 
        195                 200                 205             


Thr Thr Gly Lys Leu Asn Pro Glu Ile Val Val Gly Val Asp Leu Gly 
    210                 215                 220                 


Phe Ser Ile Pro Leu Tyr Val Ala Leu Asn Ser Gly His Ala Arg Leu 
225                 230                 235                 240 


Gly Tyr Leu His Phe Lys Ala Leu Gly Glu Arg Ile Lys Ser Leu Gln 
                245                 250                 255     


Lys Gln Val Met Ala Arg Arg Arg Ala Ile Gln Arg Gly Gly Arg Val 
            260                 265                 270         


Ser Ile Ser His Ser Thr Ala Arg Thr Gly His Gly Val Lys Arg Lys 
        275                 280                 285             


Leu Gln Pro Thr Glu Lys Leu Arg Gly Arg Ile Glu Lys Ser Tyr Ser 
    290                 295                 300                 


Thr Leu Asn His Gln Leu Ser Ala Ser Val Ile Asp Phe Ala Lys Asn 
305                 310                 315                 320 


His His Ala Gly Val Ile Gln Ile Glu Asp Leu Ser Gly Leu Lys Glu 
                325                 330                 335     


Gln Leu Thr Gly Thr Phe Ile Gly Ala Arg Trp Arg Tyr His Gln Leu 
            340                 345                 350         


Gln Gln Phe Leu Lys Tyr Lys Ala Glu Glu Ala Gly Ile Thr Leu Lys 
        355                 360                 365             


Gln Ile Asn Pro Arg Tyr Thr Ser Arg Arg Cys Ser Glu Cys Gly Phe 
    370                 375                 380                 


Ile Asn Met Asp Phe Asp Arg Ala Phe Arg Asp Ala Gly Arg Thr Tyr 
385                 390                 395                 400 


Gly Lys Val Thr Lys Phe Leu Cys Pro Glu Cys Gly Tyr Glu Ala Asp 
                405                 410                 415     


Pro Asp Tyr Asn Ala Ala Arg Asn Ile Ala Thr Leu Asp Ile Glu Lys 
            420                 425                 430         


Leu Ile Arg Val Gln Cys Glu Lys His Gly Leu Lys Phe Asp Ala His 
        435                 440                 445             


<210> 127
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 127
Val Gly Lys Glu Gly Lys Arg Asn Val Lys Val Met Lys Ile Arg Ile 
1               5                   10                  15      


Leu Lys Pro Cys Asp Gly Met Thr Trp Asn Glu Leu Gly Gln Leu Leu 
            20                  25                  30          


Arg Asp Ala Arg Tyr Arg Val Phe Arg Leu Ala Asn Leu Thr Val Ser 
        35                  40                  45              


Glu Ala Tyr Leu Asn Phe His Leu Trp Arg Thr Gly Arg Ser Gln Glu 
    50                  55                  60                  


Phe Lys Lys Gln Thr Ile Gly Gln Leu Asn Arg Gln Leu Arg Asn Ile 
65                  70                  75                  80  


Leu Gln Gln Glu Lys Tyr Asp Asp Glu Lys Leu Asn Arg Tyr Ser Lys 
                85                  90                  95      


Thr Gly Ala Leu Pro Asp Thr Val Cys Ser Ala Leu Trp Gln Tyr Lys 
            100                 105                 110         


Leu Met Ala Val Met Lys Lys Ser Lys Trp Ser Glu Val Ile Arg Gly 
        115                 120                 125             


Lys Ser Ser Leu Pro Thr Phe Arg Asn Asp Met Ala Ile Pro Val Arg 
    130                 135                 140                 


Cys Asp Lys Pro Glu Gln Lys Arg Ile Glu Lys Thr Glu Gln Gly Gln 
145                 150                 155                 160 


Val Glu Ala Ala Leu Gln Val Cys Val Gln Pro Tyr Pro Arg Val Ile 
                165                 170                 175     


Leu Gly Thr His Thr Leu Gly Asp Gly Gln Asp Ala Ile Leu Lys Arg 
            180                 185                 190         


Leu Leu Asp Asn Gln Asn Gln Ala Ile Gly Gly Tyr Arg Gln Arg Ser 
        195                 200                 205             


Phe Glu Ile Lys Tyr Asp Glu Gln Lys Arg Trp Trp Leu Phe Ile Thr 
    210                 215                 220                 


Tyr Asp Phe Pro Ala Thr Glu Val Ala Thr Asp Lys Thr Ile Ala Val 
225                 230                 235                 240 


Gly Val Asp Leu Gly Val Ser Val Pro Leu Tyr Ala Ala Val Asn Asn 
                245                 250                 255     


Gly Pro Ala Arg Leu Gly Arg Arg Glu Phe Gly Gly Leu Gly Arg Arg 
            260                 265                 270         


Ile Arg Asp Leu Arg Asn Gln Thr Asp Ala Arg Arg Arg Ser Ile Gln 
        275                 280                 285             


Arg Ser Gly Arg Glu Gly Gln Ser Asp Asp Thr Ala Arg Ala Gly His 
    290                 295                 300                 


Gly Arg Lys Arg Lys Leu Leu Pro Ile His Ile Leu Glu Gly Arg Leu 
305                 310                 315                 320 


Asp Lys Ala Tyr Thr Thr Leu Asn His Gln Met Ser Ala Ala Val Ile 
                325                 330                 335     


Lys Phe Ala Ala Glu Gln Gly Ala Gly Ile Ile Gln Ile Glu Asn Leu 
            340                 345                 350         


Ala Gly Leu Gln Asp Glu Leu Arg Gly Thr Phe Ile Gly Gly Arg Trp 
        355                 360                 365             


Arg Tyr Arg Gln Leu Gln Asp Phe Leu Lys Tyr Lys Thr Gln Glu Met 
    370                 375                 380                 


Gly Ile Glu Leu Arg Gln Val Asn Pro Lys Tyr Thr Ser Arg Arg Cys 
385                 390                 395                 400 


Ser Lys Cys Gly Phe Ile His Lys Asp Phe Asp Arg Asp Tyr Arg Asn 
                405                 410                 415     


Arg His Ser Glu Asn Gly Lys Pro Ala Gln Phe Val Cys Pro Asn Pro 
            420                 425                 430         


Asp Cys Lys Tyr Glu Ser Asp Pro Asp Tyr Asn Ala Ala Arg Asn Leu 
        435                 440                 445             


Ala Thr Leu Asp Ile Glu Glu Gln Ile Arg Val Gln Cys Gln Lys Gln 
    450                 455                 460                 


Gly Leu Glu Tyr Asp Ser Lys Lys Asp Lys Asn Ala Leu 
465                 470                 475         


<210> 128
<211> 472
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 128
Met Lys Glu Lys Ser Lys Thr Leu Val Lys Val Ala Arg Leu Arg Ile 
1               5                   10                  15      


Leu Lys Pro Ala Gly Asp Met Thr Trp Ser Glu Leu Gly Glu Met Leu 
            20                  25                  30          


Arg Thr Val Arg Tyr Arg Val Phe Arg Leu Ala Asn Leu Ala Val Ser 
        35                  40                  45              


Glu Ala Tyr Leu Gly Phe His Met Phe Arg Thr Gln Arg Ala Ala Glu 
    50                  55                  60                  


Phe Lys Ala Glu Thr Met Gly Lys Leu Ser Arg Arg Leu Arg Glu Met 
65                  70                  75                  80  


Leu Ile Glu Glu Gly Val Asp Glu Lys Glu Leu Asn Cys Tyr Ser Leu 
                85                  90                  95      


Thr Gly Ala Val Pro Asp Thr Val Ala Gly Ala Leu His Gln Tyr Lys 
            100                 105                 110         


Ile Arg Gly Ile Thr Ser Pro Thr Lys Trp Arg Gln Val Val Arg Gly 
        115                 120                 125             


Gln Ala Ala Leu Pro Thr Phe Arg Asn Asp Met Ser Ile Pro Ile Arg 
    130                 135                 140                 


Cys Asp Lys Pro Tyr Gln Arg Arg Leu Glu Lys Thr Glu Ala Gly Glu 
145                 150                 155                 160 


Val Glu Val Glu Leu Met Ile Cys Arg Lys Pro Tyr Pro Arg Ile Val 
                165                 170                 175     


Leu Gly Thr Ala Asp Val Gly Pro Gly Gln Glu Val Ile Leu Glu Arg 
            180                 185                 190         


Leu Leu Gln Asn Lys Asp Asn Ser Ser Asp Gly Tyr Arg Gln Arg Leu 
        195                 200                 205             


Phe Glu Ala Lys Gln Asp Arg Gln Thr Gly Lys Trp Trp Leu Tyr Val 
    210                 215                 220                 


Thr Tyr Asp Phe Pro Arg Pro Glu Glu Gly Glu Leu Asn Pro Glu Ile 
225                 230                 235                 240 


Val Val Gly Val Asp Leu Gly Phe Ser Val Pro Leu Tyr Val Ala Ile 
                245                 250                 255     


Asn Asn Gly Tyr Ala Arg Leu Gly Arg Arg His Phe Gln Ala Leu Gly 
            260                 265                 270         


Asn Arg Ile Arg Ser Leu Gln Arg Gln Val Leu Ala Arg Arg Arg Ser 
        275                 280                 285             


Ile Gln Arg Gly Gly Arg Val Asn Ile Ser His Asp Thr Ala Arg Ser 
    290                 295                 300                 


Gly His Gly Ile Lys Arg Lys Leu Leu Pro Thr Glu Lys Leu Arg Gly 
305                 310                 315                 320 


Arg Ile Glu Lys Ser Tyr Ser Thr Leu Asn His Gln Leu Ser Ala Ser 
                325                 330                 335     


Val Ile Asp Phe Thr Lys Asn His His Ala Gly Thr Ile Gln Ile Glu 
            340                 345                 350         


Asp Leu Ala Asn Leu Lys Glu Val Leu Ala Gly Thr Phe Ile Gly Ala 
        355                 360                 365             


Arg Trp Arg Tyr His Gln Leu Gln Gln Phe Leu Lys Tyr Lys Ala Asp 
    370                 375                 380                 


Glu Ala Gly Ile Thr Leu Lys Glu Val Asn Pro Arg Tyr Thr Ser Arg 
385                 390                 395                 400 


Arg Cys Ser Glu Cys Gly Phe Ile His Lys Asp Phe Asp Arg Ala Phe 
                405                 410                 415     


Arg Asp Ser Gly Arg Thr Asp Gly Lys Val Ala Arg Phe Val Cys Pro 
            420                 425                 430         


Glu Cys Gly Tyr Gly Pro Val Asp Pro Asp Tyr Asn Ala Ala Lys Asn 
        435                 440                 445             


Ile Ser Thr Leu Asp Ile Glu Lys His Ile Arg Val Gln Cys Lys Lys 
    450                 455                 460                 


Gln Gly Leu Glu Tyr Glu Val His 
465                 470         


<210> 129
<211> 470
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 129
Met Lys Glu Lys Ala Lys Thr Leu Val Lys Val Ala Arg Leu Arg Ile 
1               5                   10                  15      


Leu Lys Pro Ala Gly Asp Met Thr Trp Pro Glu Leu Gly Asn Met Leu 
            20                  25                  30          


Arg Thr Val Arg Tyr Arg Val Phe Arg Leu Ala Asn Leu Ala Val Ser 
        35                  40                  45              


Glu Ala Tyr Leu Gly Phe His Met Phe Arg Thr Lys Arg Ala Glu Glu 
    50                  55                  60                  


Phe Lys Ala Glu Thr Met Gly Lys Leu Ser Arg Arg Leu Arg Glu Met 
65                  70                  75                  80  


Leu Ile Glu Glu Gly Val Asp Glu Lys Asp Leu Ser Arg Tyr Ser Gln 
                85                  90                  95      


Thr Gly Ala Val Pro Asp Thr Val Ala Gly Ala Leu Ser Gln Tyr Lys 
            100                 105                 110         


Ile Arg Gly Ile Thr Ser Pro Thr Lys Trp Arg Gln Ile Val Arg Gly 
        115                 120                 125             


Gln Val Ala Leu Pro Thr Phe Arg Asn Thr Met Ser Ile Pro Val Arg 
    130                 135                 140                 


Cys Asp Lys Leu Tyr Gln Arg Arg Leu Glu Gln Gly Asp Ser Gly Glu 
145                 150                 155                 160 


Val Glu Val Glu Leu Met Ile Cys Arg Asn Pro Tyr Pro Arg Val Val 
                165                 170                 175     


Leu Gly Thr Gly Asp Leu Asn Pro Gly Gln Gln Ala Ile Leu Glu Arg 
            180                 185                 190         


Leu Leu Gln Asn Thr Asp Asn Ser Ala Asp Gly Tyr Arg Gln Arg Leu 
        195                 200                 205             


Phe Glu Ile Lys Glu Asp Val Gln Thr Arg Lys Trp Trp Leu Tyr Val 
    210                 215                 220                 


Thr Tyr Asp Phe Pro Lys Thr Thr Gly Lys Leu Asn Pro Glu Ile Val 
225                 230                 235                 240 


Val Gly Val Asp Leu Gly Phe Ser Ile Pro Leu Tyr Val Ala Leu Asn 
                245                 250                 255     


Ser Gly His Ala Arg Leu Gly Tyr Leu His Phe Lys Ala Leu Gly Glu 
            260                 265                 270         


Arg Ile Lys Ser Leu Gln Lys Gln Val Met Ala Arg Arg Arg Ala Ile 
        275                 280                 285             


Gln Arg Gly Gly Arg Val Ser Ile Ser His Ser Thr Ala Arg Thr Gly 
    290                 295                 300                 


His Gly Val Lys Arg Lys Leu Gln Pro Thr Glu Lys Leu Arg Gly Arg 
305                 310                 315                 320 


Ile Glu Lys Ser Tyr Ser Thr Leu Asn His Gln Leu Ser Ala Ser Val 
                325                 330                 335     


Ile Asp Phe Ala Lys Asn His His Ala Gly Val Ile Gln Ile Glu Asp 
            340                 345                 350         


Leu Ser Gly Leu Lys Glu Gln Leu Thr Gly Thr Phe Ile Gly Ala Arg 
        355                 360                 365             


Trp Arg Tyr His Gln Leu Gln Gln Phe Leu Lys Tyr Lys Ala Glu Glu 
    370                 375                 380                 


Ala Gly Ile Thr Leu Lys Gln Ile Asn Pro Arg Tyr Thr Ser Arg Arg 
385                 390                 395                 400 


Cys Ser Glu Cys Gly Phe Ile Asn Met Asp Phe Asp Arg Ala Phe Arg 
                405                 410                 415     


Asp Ala Gly Arg Thr Tyr Gly Lys Val Thr Lys Phe Leu Cys Pro Glu 
            420                 425                 430         


Cys Gly Tyr Glu Ala Asp Pro Asp Tyr Asn Ala Ala Arg Asn Ile Ala 
        435                 440                 445             


Thr Leu Asp Ile Glu Lys Leu Ile Arg Val Gln Cys Glu Lys His Gly 
    450                 455                 460                 


Leu Lys Phe Asp Ala His 
465                 470 


<210> 130
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 130
Met Ala Lys Lys Ala Lys Thr Met Phe Lys Val Thr Asn Phe Arg Ile 
1               5                   10                  15      


Leu Lys Pro Ala Gly Asp Met Thr Trp Lys Glu Leu Gly Gln Leu Leu 
            20                  25                  30          


Arg Asp Ala Arg Tyr Arg Thr Phe Arg Met Ala Asn Leu Ala Leu Ser 
        35                  40                  45              


Glu Ala Tyr Leu Asn Phe Tyr Leu Leu Lys Lys Gly Asp Leu Lys Glu 
    50                  55                  60                  


Tyr Lys Asn Val Lys Ile Gly Gln Ile Ala Lys Arg Leu Arg Asp Met 
65                  70                  75                  80  


Leu Ile Glu Glu Gly Val Asp Glu Glu Val Gln Asn Arg Phe Ser Pro 
                85                  90                  95      


Lys Val Ala Leu Pro Ala Tyr Val Tyr Ser Ala Leu Asp Gln Phe Lys 
            100                 105                 110         


Leu Arg Gly Leu Thr Ser Lys Ser Asn Trp Lys Lys Val Leu Arg Gly 
        115                 120                 125             


Gln Ala Ser Leu Pro Thr Phe Arg Leu Asn Met Ser Val Pro Ile Arg 
    130                 135                 140                 


Cys Asp Lys Pro Glu His Arg Arg Leu Glu Lys Thr Glu Asn Gly Asn 
145                 150                 155                 160 


Val Glu Val Asp Leu Met Ile Cys Arg Lys Pro Tyr Pro Arg Val Val 
                165                 170                 175     


Leu Glu Thr Leu Lys Leu Asp Gly Ser Ser Lys Ala Ile Leu Asp Arg 
            180                 185                 190         


Leu Leu Glu Asn Glu Asp Asn Ser Pro Gly Asn Tyr Arg Gln Arg Cys 
        195                 200                 205             


Phe Glu Val Lys Gln Asn Pro Arg Ser Asn Asp Trp Trp Leu Tyr Val 
    210                 215                 220                 


Thr Tyr Glu Met Pro Val Asp Lys Asp Lys Lys Leu Asp Pro Lys Val 
225                 230                 235                 240 


Ile Val Gly Val Asp Leu Gly Phe Ser Val Pro Leu Tyr Val Ala Ile 
                245                 250                 255     


Asn Asn Gly His Ala Arg Leu Gly Arg Arg His Phe Gln Ala Leu Gly 
            260                 265                 270         


Lys Arg Ile His Asn Leu Gln Asn Gln Val Leu Ala Arg Arg Arg Ser 
        275                 280                 285             


Ile Gln Arg Gly Gly Gln Val Asn Leu Ser His Ser Thr Ser Arg Ser 
    290                 295                 300                 


Gly His Gly Arg Lys Arg Lys Leu Gln Pro Thr Glu Lys Leu Gln Gln 
305                 310                 315                 320 


Lys Ile Asn Ser Ala Tyr Ser Thr Leu Asn His Gln Leu Ser Ser Ser 
                325                 330                 335     


Val Ile Asp Phe Ala Asn Asn His Lys Ala Gly Thr Ile Gln Ile Glu 
            340                 345                 350         


Asp Leu Glu Thr Leu Lys Glu Gln Leu Thr Gly Thr Tyr Ile Gly Arg 
        355                 360                 365             


Gln Trp Arg Tyr Tyr Gln Leu Gln Gln Phe Ile Glu Tyr Lys Ala Lys 
    370                 375                 380                 


Glu Asn Ser Ile Thr Val Lys Lys Ile Asn Pro Lys Tyr Thr Ser Arg 
385                 390                 395                 400 


Arg Cys Ser Met Cys Gly His Ile His Ala Asp Phe Asp Arg Thr Phe 
                405                 410                 415     


Arg Asp Arg Ser Ser Asn Lys Gly Phe Val Thr Lys Phe Ile Cys Pro 
            420                 425                 430         


Glu Cys Asn Phe Glu Ala Asp Pro Asp Tyr Asn Ala Ala Lys Asn Ile 
        435                 440                 445             


Ser Thr Leu Asp Ile Glu Asn Lys Ile Lys Leu Gln Cys Lys Lys Gln 
    450                 455                 460                 


Lys Ile Asp Tyr 
465             


<210> 131
<211> 457
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 131
Met Pro Lys Ile Thr Arg Lys Ile Glu Leu Leu Phe Asp Arg Ser Gly 
1               5                   10                  15      


Leu Ser Glu Glu Glu Cys Lys Glu Lys Trp Arg Phe Ile Tyr Gln Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Val Ala Asn Arg Leu Val Asn Gln Leu Tyr 
        35                  40                  45              


Leu Ala Asp Glu Ile Asp Asp Ile Leu Arg Leu Ser Asp Gln Glu Tyr 
    50                  55                  60                  


Ile Ala Leu Arg Lys Lys Leu Ala Asn Lys Lys Leu Asp Glu Ala Thr 
65                  70                  75                  80  


Arg Ile Ser Leu Glu Glu Gln Met Ser Gln Val Met Lys Arg Val Asn 
                85                  90                  95      


Glu Arg Arg Ser Ala Ile Leu Gln Arg Pro Gln Gln Ser Phe Ala Tyr 
            100                 105                 110         


Ser Val Val Thr Asp Ser Asp Thr Glu Gly Leu Thr Ala Lys Ile Leu 
        115                 120                 125             


Asp Val Leu Lys Gln Asp Val Leu Ser His Tyr Lys Ala Asp Thr Lys 
    130                 135                 140                 


Glu Val Leu Lys Gly Glu Lys Ser Ile Ser Asn Tyr Lys Lys Gly Met 
145                 150                 155                 160 


Pro Ile Pro Phe Ala Phe Asn Asp Ser Leu Arg Leu Tyr Lys Glu Asp 
                165                 170                 175     


Gly Phe Phe Tyr Leu Lys Trp Tyr Asn Gly Ile Arg Phe Leu Leu Asn 
            180                 185                 190         


Phe Gly Arg Asp Ala Ser Asn Asn Gln Leu Ile Val Glu Arg Cys Leu 
        195                 200                 205             


Gly Ile Ser Lys Asp Glu Ile Ser Tyr Lys Ala Cys Ser Ser Ser Ile 
    210                 215                 220                 


Gln Ile Lys Lys Lys Gly Asn His Ser Lys Ile Phe Leu Leu Leu Val 
225                 230                 235                 240 


Val Asp Val Pro Val Glu Gln Tyr Ala Gln Lys Pro Asn Met Val Val 
                245                 250                 255     


Gly Val Asp Leu Gly Leu Asn Val Pro Ile Tyr Ala Ala Ser Asn Ser 
            260                 265                 270         


Thr Leu Glu Arg Lys Ala Ile Gly Ser Arg Glu Ala Phe Leu Asn Gln 
        275                 280                 285             


Arg Gly Ala Phe Gln Arg Arg Phe Arg Ala Leu Gln Arg Leu Gln Thr 
    290                 295                 300                 


Thr Lys Gly Gly Arg Gly Arg Leu His Lys Leu Glu Pro Leu Glu Arg 
305                 310                 315                 320 


Val Arg Glu Ala Glu Arg Asn Trp Val Arg Thr Gln Asn His Leu Phe 
                325                 330                 335     


Ser Arg Glu Val Ile Asn Phe Ala Ile Asp Val Gly Ala Ser Thr Ile 
            340                 345                 350         


Gln Met Glu Lys Leu Ala Asn Phe Gly Arg Asp Ala Gln Gly Glu Val 
        355                 360                 365             


Arg Glu Asp Lys Lys Tyr Val Leu Arg Asn Trp Ser Tyr Phe Glu Leu 
    370                 375                 380                 


Gln Asn Leu Ile Glu Tyr Lys Ala Lys Arg Ala Gly Ile Lys Val Lys 
385                 390                 395                 400 


Tyr Ile Asn Pro Ala Phe Thr Ser Gln Thr Cys Ser Glu Cys Gly Gln 
                405                 410                 415     


Leu Gly Glu Arg Asp Ser Ile His Phe Lys Cys Thr Asn Pro Asp Cys 
            420                 425                 430         


Pro Asn Cys Gly Lys Asp Ile His Ala Asp Tyr Asn Gly Ala Arg Asn 
        435                 440                 445             


Ile Ala Lys Ser Lys Asp Tyr Ile Lys 
    450                 455         


<210> 132
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 132
Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210> 133
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 133
Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Asp Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Lys Lys Lys Val Ala Ala Thr Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ser Thr Glu Phe Glu Thr 
        115                 120                 125             


Lys Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Lys Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Thr Asp Ser 
                165                 170                 175     


Leu Arg Ile Lys Lys Asp Asn Lys Asp Phe Tyr Leu Leu Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Val Lys Leu Phe Leu Leu Leu Val Val Ser Ile Pro Lys Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Ser Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Thr Gly Gly Lys Gly Arg Thr 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Thr His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ser Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln His Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Ala Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Glu Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210> 134
<211> 469
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 134
Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Gln Glu Arg Lys Asp Gln Trp Asn Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Gly Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Arg Ala Leu Glu Lys Ala Lys Lys Gln Lys Ala Pro 
65                  70                  75                  80  


Asp Glu Glu Val Ile Ala Glu Leu Ser Gln Gln Val Ala Thr Ala Glu 
                85                  90                  95      


Gln Glu Met Asp Glu Gln Ala Lys Ala Ile Cys Gln Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Thr Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Gly Gln Ile Leu Thr Cys Leu Arg Gln Gly Val Phe Ser 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ser Ile 
145                 150                 155                 160 


Arg Thr Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asp Ser 
                165                 170                 175     


Leu Arg Ile Gly Phe Glu Asp Gly Glu Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Arg Phe Asp Phe Gly Lys Asp Arg Ser Asn Asn Cys 
        195                 200                 205             


Leu Ile Val Gln Arg Cys Met Lys Met Asp Lys Asp Tyr Glu Gly Asp 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Met Val Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Pro Lys Phe Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu Arg Val 
                245                 250                 255     


Glu Leu Asn Lys Asn Ile Val Val Gly Val Asp Leu Gly Ile Asn Ala 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Thr Thr Pro Glu Arg Lys Gln Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Glu Arg Met Ala Phe Gln Arg Arg Phe 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Thr Gly Gly Arg Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu Gln Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Ile Asp Phe Ala 
            340                 345                 350         


Val Lys Ala Arg Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Thr Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly His Gln Gly Phe Arg Glu Gly Ile Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys Phe Gly Glu Lys Glu His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Glu Ile Ile 
    450                 455                 460                 


Lys Asn Asn Glu Glu 
465                 


<210> 135
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 135
Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Thr Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Arg Glu Leu Ala Arg Ala Glu Lys Gln Lys Lys Pro 
65                  70                  75                  80  


Asp Val Asp Ala Ile Ala Glu Leu Arg Glu Lys Val Thr Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Ser Asp Gln Glu Arg Ala Ile Cys Thr Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Ile Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Val Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Val Lys Leu Phe Leu Leu Leu Val Val Ser Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Ala Gly Gly Lys Gly Arg Thr 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Arg Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210> 136
<211> 463
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 136
Met Pro Thr Met Thr Arg Lys Ile Glu Leu Lys Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Glu Glu Arg Lys Ala Gln Leu Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Asn Glu Phe Glu Lys Ala Lys Lys Lys Gly Asp Glu 
65                  70                  75                  80  


Glu Gln Ile Val Glu Leu Ser Leu Arg Val Ala Ala Ala Glu Lys Glu 
                85                  90                  95      


Leu Thr Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu Met Ser 
            100                 105                 110         


Thr Asp Thr Leu Ala Tyr Arg Phe Ala Asn Glu Ile Glu Ile Asn Val 
        115                 120                 125             


Phe Gly Gln Ile Leu Ala Cys Leu Lys Gln Gly Ile His Ser Thr Phe 
    130                 135                 140                 


Lys Lys Asp Ala Ala Asp Val Lys Arg Gly Glu Arg Ala Ile Arg Asn 
145                 150                 155                 160 


Phe Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Ser Lys Ser Ile Arg 
                165                 170                 175     


Ile Glu Asn Glu Gly Ser Asp Phe Tyr Leu Arg Trp Tyr Asn Gly Leu 
            180                 185                 190         


Arg Phe Arg Phe Asp Phe Gly Lys Asp Arg Ser Asn Asn Arg Leu Ile 
        195                 200                 205             


Val Ser Arg Cys Leu Asn Leu Asp Pro Asp Phe Glu Asp Glu Tyr Lys 
    210                 215                 220                 


Leu Ser Asn Ser Ser Leu Gln Met Val Lys Arg Asp Gly Arg Pro Lys 
225                 230                 235                 240 


Leu Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu Asn Val Glu Leu 
                245                 250                 255     


Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Ile Asn Ser Pro Ala 
            260                 265                 270         


Tyr Val Ala Thr Asn Ile Thr Met Glu Arg Gln Arg Ile Gly Ser Arg 
        275                 280                 285             


Asp Thr Phe Leu Asn Ala Arg Met Ala Ile Gln Arg Arg Phe Gln Ser 
    290                 295                 300                 


Leu Gln Lys Leu Gln Asn Thr Ala Gly Gly Arg Gly Arg Lys Lys Lys 
305                 310                 315                 320 


Leu Glu Pro Leu Glu Arg Leu Lys Glu Thr Glu Arg Asn Trp Val Arg 
                325                 330                 335     


Thr Gln Asn His Leu Phe Ser Arg Asp Val Val Gln Phe Ala Val Lys 
            340                 345                 350         


Thr Arg Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe Gly Lys 
        355                 360                 365             


Asp Asp Asp Gly Asn Ala Asp Glu Lys Lys Glu Phe Val Leu Arg Asn 
    370                 375                 380                 


Trp Ser Tyr Tyr Glu Leu Gln Thr Met Ile Lys Tyr Lys Ala Ala Lys 
385                 390                 395                 400 


Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser Arg Thr 
                405                 410                 415     


Cys Ser Trp Cys Gly His Glu Gly Asp Arg Lys Gly Glu Thr Phe Ile 
            420                 425                 430         


Cys Glu Asn Pro Glu Cys Glu Lys Tyr Gly Lys Lys Glu Asn Ala Asp 
        435                 440                 445             


Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Thr Asp Ile Ile Lys 
    450                 455                 460             


<210> 137
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 137
Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Gln Thr Pro 
65                  70                  75                  80  


Asp Glu Gly Leu Ile Ala Glu Leu Ser Arg Lys Leu Ser Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Ala Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Thr Leu Ser Tyr Asn Phe Ala Lys Glu Ile Glu Thr 
        115                 120                 125             


Asn Ile Phe Gly Gln Ile Leu Thr Cys Leu Arg Gln Gly Val Tyr Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Lys Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asn Ser 
                165                 170                 175     


Leu Lys Ile Glu Ser Asp Ser Gly Glu Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Leu Thr Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Met Ile Val Asn Arg Cys Met Lys Met Asp Glu Asp Phe Glu Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Leu Ala Lys Arg Asp Gly Lys 
225                 230                 235                 240 


Pro Lys Leu Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu His Val 
                245                 250                 255     


Lys Leu Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Val Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Thr Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Ala Gly Gly Lys Gly Arg Thr 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Asp Ala Glu Arg Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asn Phe Ala 
            340                 345                 350         


Val Gln Ala Arg Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Lys Asp Gly Asn Ala Asp Glu Lys Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Phe Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ser 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Val Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Gln Gly Asp Arg Lys Ser Thr Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Lys Cys Lys His Tyr Gly Glu Ser Ile His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Asn Asp Ile Val 
    450                 455                 460                 


Lys Glu Asn Glu 
465             


<210> 138
<211> 467
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 138
Met Pro Lys Ile Thr Arg Lys Ile Glu Met Thr Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Thr Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Met Lys His Ala Asp Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Lys Ala Glu Lys Lys Ser Pro Asp 
65                  70                  75                  80  


Glu Asp Leu Ile Ala Glu Leu Arg Glu Lys Leu Ala Ala Ala Glu Gln 
                85                  90                  95      


Glu Met Thr Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu Met 
            100                 105                 110         


Ser Thr Gln Thr Leu Ala Tyr Lys Phe Ala Thr Glu Ile Glu Ile Asn 
        115                 120                 125             


Val Phe Gly Gln Ile Leu Ala Cys Leu Lys Gln Ala Ala Gln Ser Asn 
    130                 135                 140                 


Phe Lys Ser Asp Ala Lys Asp Val Lys Arg Gly Glu Arg Ala Ile Arg 
145                 150                 155                 160 


Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asp Asn Ile 
                165                 170                 175     


Arg Ile Asp Ala Asp Gly Asp Glu Phe Tyr Leu Arg Trp Tyr Asn Gly 
            180                 185                 190         


Leu Arg Phe His Leu Thr Phe Gly Lys Asp Lys Ser Asn Asn Arg Met 
        195                 200                 205             


Ile Val Lys Arg Cys Leu Lys Met Asp Lys Asp Phe Glu Gly Glu Tyr 
    210                 215                 220                 


Lys Leu Cys Asn Ser Ser Ile Gln Met Val Lys Arg Asp Gly Lys Pro 
225                 230                 235                 240 


Lys Leu Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu His Val Glu 
                245                 250                 255     


Leu Asn Lys Asn Val Val Val Gly Val Asp Leu Gly Val Asn Val Pro 
            260                 265                 270         


Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly Glu 
        275                 280                 285             


Arg Glu His Phe Leu Asn Thr Arg Met Gln Ile Gln Arg Arg Tyr Lys 
    290                 295                 300                 


Ser Leu Gln Arg Leu Lys Ala Thr Ala Gly Gly Lys Gly Arg Thr Lys 
305                 310                 315                 320 


Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp Val 
                325                 330                 335     


His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asn Phe Ala Val 
            340                 345                 350         


Gln Thr His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe Gly 
        355                 360                 365             


Lys Asp Asp Asp Gly Asn Ala Asp Glu Gln Lys Glu Phe Val Leu Arg 
    370                 375                 380                 


Asn Trp Ser Phe Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala Ala 
385                 390                 395                 400 


Lys Tyr Gly Ile Lys Val Glu Lys Val Lys Pro Ala Tyr Thr Ser Lys 
                405                 410                 415     


Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Gln Gly Val Thr Phe 
            420                 425                 430         


Ile Cys Glu Asn Pro Ala Cys Lys Gln Cys Gly Glu Lys Val His Ala 
        435                 440                 445             


Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile Lys 
    450                 455                 460                 


Lys Asn Glu 
465         


<210> 139
<211> 469
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 139
Met Pro Thr Ile Thr Arg Lys Ile Glu Leu His Leu Cys Thr Asp Gly 
1               5                   10                  15      


Leu Thr Asp Glu Gln Gln Lys Ala Gln Arg Leu Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Val Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Leu Lys His Asp Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Ser Arg Glu Leu Ala Arg Ala Glu Lys Lys His Asp Asp 
65                  70                  75                  80  


Glu Leu Thr Thr Glu Leu Arg Gly Lys Leu Ala Ala Ala Glu Arg Glu 
                85                  90                  95      


Met Thr Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu Met Ser 
            100                 105                 110         


Thr Gln Ser Leu Ser Tyr Arg Leu Val Thr Glu Leu Glu Thr Lys Ile 
        115                 120                 125             


Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Tyr Ala Thr Phe 
    130                 135                 140                 


Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile Arg Asn 
145                 150                 155                 160 


Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asn Asp Ser Val Arg 
                165                 170                 175     


Ile Glu Tyr Asp Glu Lys Glu Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Asp Ile Arg Phe Lys Phe His Phe Gly Arg Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Ser Arg Cys Leu Lys Leu Asp Lys Asp Tyr Glu Gly Asp 
    210                 215                 220                 


Tyr Gln Leu Cys Asn Ser Ser Ile Gln Ile Val Lys Arg Asp Gly Ser 
225                 230                 235                 240 


Thr Lys Phe Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Arg Ile Val Val Gly Val Asp Leu Gly Ile Asn Tyr 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Cys Thr Glu Glu Arg Met Tyr Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Thr Arg Met Gln Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Lys Leu Lys Gly Thr Ala Gly Gly Lys Gly Arg Ser 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Asn Ala Glu Arg Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Leu Lys Val Val Asn Phe Ala 
            340                 345                 350         


Val Gln Thr His Ala Ala Thr Ile His Leu Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asp Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Ser Met Ile Glu Tyr Lys Ala 
385                 390                 395                 400 


Lys Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Gln Thr Cys Ser Trp Cys Gly Gln Arg Gly Phe Arg Gln Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys Cys Gly Glu Lys Glu Asn 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Val Ile 
    450                 455                 460                 


Lys Asp Lys Asn Glu 
465                 


<210> 140
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 140
Thr Pro Phe Val Leu Tyr Phe Gln Asn Tyr Ser Leu Ser Leu Arg Gln 
1               5                   10                  15      


His Ile Thr Leu Tyr Ser Met Pro Thr Ile Thr Arg Lys Ile Glu Leu 
            20                  25                  30          


Thr Leu Cys Thr Glu Gly Leu Ser Asp Gln Glu Arg Lys Asp Gln Trp 
        35                  40                  45              


Asn Leu Leu Tyr His Ile Asn Asp Asn Leu Tyr Arg Ala Ala Asn Asn 
    50                  55                  60                  


Ile Ser Ser Lys Leu Tyr Leu Asp Asp His Val Gly Ser Met Val Arg 
65                  70                  75                  80  


Leu Lys His Ala Glu Tyr Leu Ser Leu Leu Arg Ala Met Glu Lys Ala 
                85                  90                  95      


Lys Lys Gln Lys Ala Pro Asp Glu Glu Val Ile Ala Glu Leu Ser Gln 
            100                 105                 110         


Gln Val Ala Ala Ala Glu Gln Glu Met Asp Glu Gln Ala Lys Ala Ile 
        115                 120                 125             


Cys Gln Tyr Ala Thr Glu Met Ser Thr Gln Thr Leu Ser Tyr Arg Phe 
    130                 135                 140                 


Ala Thr Glu Leu Glu Thr Asn Ile Phe Gly Gln Ile Leu Thr Cys Leu 
145                 150                 155                 160 


Arg Gln Gly Val Phe Ser Thr Phe Asn Ser Asp Ala Arg Asp Val Lys 
                165                 170                 175     


Arg Gly Glu Arg Ser Ile Arg Thr Tyr Lys Lys Gly Met Pro Ile Pro 
            180                 185                 190         


Phe Pro Trp Asn Asp Ser Leu Arg Ile Gly Phe Glu Asp Gly Glu Phe 
        195                 200                 205             


Tyr Leu Arg Trp Tyr Asn Gly Leu Arg Phe Arg Phe Asp Phe Gly Lys 
    210                 215                 220                 


Asp Arg Ser Asn Asn Arg Leu Ile Val Gln Arg Cys Met Lys Met Asp 
225                 230                 235                 240 


Lys Asp Tyr Glu Gly Asp Tyr Lys Leu Cys Asn Ser Ser Ile Gln Met 
                245                 250                 255     


Val Lys Arg Glu Gly Lys Pro Lys Phe Phe Leu Leu Leu Val Val Asn 
            260                 265                 270         


Ile Pro Gln Glu Arg Val Glu Leu Asn Lys Asn Ile Val Val Gly Val 
        275                 280                 285             


Asp Leu Gly Ile Asn Ala Pro Ala Tyr Val Ala Thr Asn Thr Thr Pro 
    290                 295                 300                 


Glu Arg Lys Gln Ile Gly Asp Arg Glu His Phe Leu Asn Glu Arg Met 
305                 310                 315                 320 


Ala Phe Gln Arg Arg Phe Lys Ser Leu Gln Arg Leu Lys Gly Thr Thr 
                325                 330                 335     


Gly Gly Arg Gly Arg Ala Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg 
            340                 345                 350         


Lys Ala Glu Gln Asn Trp Val His Thr Gln Asn His Leu Phe Ser Arg 
        355                 360                 365             


Glu Val Ile Asp Phe Ala Val Lys Ala Arg Ala Ala Thr Ile His Met 
    370                 375                 380                 


Glu Asp Leu Ser Gly Phe Gly Lys Asp Arg Asp Gly Asn Ala Asp Glu 
385                 390                 395                 400 


Arg Lys Glu Phe Val Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn 
                405                 410                 415     


Met Ile Thr Tyr Lys Ala Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile 
            420                 425                 430         


Arg Pro Ala Tyr Thr Ser Lys Thr Cys Ser Trp Cys Gly His Gln Gly 
        435                 440                 445             


Phe Arg Glu Gly Ile Thr Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys 
    450                 455                 460                 


Phe Gly Glu Lys Glu His Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala 
465                 470                 475                 480 


Asn Ser Lys Glu Ile Ile Lys Asn Asn Glu Glu 
                485                 490     


<210> 141
<211> 469
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 141
Met Pro Thr Ile Thr Arg Lys Ile Glu Leu His Leu Cys Thr Glu Glu 
1               5                   10                  15      


Leu Ser Asp Glu Gln Gln Lys Ala Gln Arg Leu Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Val Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Leu Lys His Asp Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Arg Glu Leu Ala Arg Ala Glu Lys Lys Ala Asp Asp 
65                  70                  75                  80  


Glu Leu Ala Thr Gln Leu Arg Glu Lys Leu Val Ala Ala Glu Arg Glu 
                85                  90                  95      


Met Thr Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu Met Ser 
            100                 105                 110         


Thr Gln Ser Leu Ser Tyr Arg Phe Val Thr Glu Leu Glu Thr Lys Ile 
        115                 120                 125             


Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Tyr Ala Thr Phe 
    130                 135                 140                 


Asn Ser Asp Ser Arg Asp Val Lys Arg Gly Glu Arg Ala Ile Arg Asn 
145                 150                 155                 160 


Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser Val Arg 
                165                 170                 175     


Ile Glu Tyr Glu Glu Lys Glu Lys Asp Phe Phe Leu Arg Trp Tyr Asn 
            180                 185                 190         


Asp Ile Arg Phe Lys Phe His Phe Gly Arg Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Ser Arg Cys Met Lys Leu Asp Lys Asp Tyr Glu Gly Asp 
    210                 215                 220                 


Tyr Gln Leu Cys Asn Ser Ser Ile Gln Ile Val Lys Arg Asp Gly Ser 
225                 230                 235                 240 


Thr Lys Tyr Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Ile Asn Tyr 
            260                 265                 270         


Pro Ala Phe Ala Ala Thr Asn Cys Thr Glu Glu Arg Met Ser Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Thr Arg Met Gln Phe Gln Arg Arg Phe 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Thr Gly Gly Lys Gly Arg Asn 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Leu Lys Val Val Asn Phe Ala 
            340                 345                 350         


Val Gln Ala His Ala Ala Thr Ile His Leu Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asp Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Lys Tyr Lys Ala 
385                 390                 395                 400 


Lys Lys Phe Gly Ile Gln Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Gln Thr Cys Ser Trp Cys Gly Gln Arg Gly Phe Arg Gln Gly Ile Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys Cys Gly Glu Lys Glu Asn 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Asp Lys Asp Glu 
465                 


<210> 142
<211> 460
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 142
Met Pro Ile Ile Thr Arg Lys Ile Glu Leu His Ile Ser Lys Glu Gly 
1               5                   10                  15      


Leu Ser Ala Glu Asp Tyr Lys Ala Gln Trp Gln Tyr Leu Arg Gln Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Met Ala Ala Asn Arg Val Ser Ser His Cys Phe 
        35                  40                  45              


Leu Asn Asp Glu Tyr Lys Tyr Arg Leu Cys Leu Gln Ile Pro Asp Tyr 
    50                  55                  60                  


Ile Asp Ile Glu Lys Gln Leu Lys Asp Ser Lys Arg Ala Arg Leu Ser 
65                  70                  75                  80  


Lys Glu Glu Leu Gly Gln Leu Lys Lys Arg Lys Lys Glu Leu Glu Asn 
                85                  90                  95      


Thr Val Lys Gly Arg Phe Gln Asp Glu Phe Glu Lys Asn Ser Leu Tyr 
            100                 105                 110         


Thr Ile Ile Ser Asn Glu Phe Gly Glu Ile Ile Pro Gly Gln Ile Leu 
        115                 120                 125             


Thr Cys Leu Arg Gln Cys Val Gln Ser Lys Tyr Asn Arg Ala Lys Glu 
    130                 135                 140                 


Glu Leu Glu Lys Gly Glu Arg Ala Ile Ser Thr Tyr Lys Lys Gly Met 
145                 150                 155                 160 


Pro Ile Pro Phe Pro Ile Asn Lys Ser Ile Arg Leu Gln Lys Gln Gly 
                165                 170                 175     


Glu Asp Phe Val Leu Lys Trp Tyr Asn Lys Ile Val Phe Lys Leu His 
            180                 185                 190         


Phe Gly Arg Asp Arg Ser Asn Asn Arg Val Ile Val Glu Arg Leu Ile 
        195                 200                 205             


Gln Ser Ala Leu Asn Asp Lys Gln Lys Gly Glu Asp Tyr Val Met Asn 
    210                 215                 220                 


Asn Ser Ser Ile Gln Leu Val Glu Lys Asp Lys Met Thr Lys Ile Phe 
225                 230                 235                 240 


Leu Leu Leu Ser Met Asp Ile Pro Thr Gln Lys Arg Lys Leu Asp Ser 
                245                 250                 255     


Glu Leu Val Leu Gly Val Asp Leu Gly Leu Asn Phe Pro Leu Tyr Tyr 
            260                 265                 270         


Ala Thr Asn Gln Ser Ala Asn Ile His Asp His Ile Gly Asp Lys Asp 
        275                 280                 285             


Ile Phe Leu Lys Glu Arg Met Val Phe Gln Arg Arg Phe Lys Glu Leu 
    290                 295                 300                 


Gln Arg Leu Gln Cys Thr Gln Gly Gly Arg Gly Arg Lys Lys Lys Leu 
305                 310                 315                 320 


Glu Pro Leu Glu Lys Leu Arg Asp Lys Glu Arg Asn Trp Val Arg Thr 
                325                 330                 335     


Lys Asn His Ile Phe Ser Arg Glu Val Ile Lys Val Ala Leu His Leu 
            340                 345                 350         


Gly Ala Gly Thr Ile His Leu Glu Asn Leu His Asn Phe Gly Lys Asp 
        355                 360                 365             


Gly Asn Gly Glu Leu Lys Asn Ser Lys Lys Phe Val Phe Arg Asn Trp 
    370                 375                 380                 


Ser Tyr Phe Glu Leu Gln Ser Met Ile Glu Tyr Lys Ala Lys Met Glu 
385                 390                 395                 400 


Gly Ile Thr Val Lys Tyr Val Asn Pro Ala Tyr Thr Ser Gln Thr Cys 
                405                 410                 415     


Ser Val Cys Gly Met Ile Gly Glu Arg Lys Glu Gln Ala Val Phe Arg 
            420                 425                 430         


Cys Met Asn Ser Ser Cys Leu Glu Tyr Gly Lys Glu Val Asn Ala Asp 
        435                 440                 445             


Phe Asn Ala Ala Arg Asn Ile Ala Lys Ala Lys Met 
    450                 455                 460 


<210> 143
<211> 466
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 143
Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Asp Gly 
1               5                   10                  15      


Leu Ser Asp Asp Leu Arg Lys Asp Gln Trp Gln Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ala Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Gly Leu Ile Lys Glu Leu Ala Lys Ala Arg Lys Arg Ala Asp Asp 
65                  70                  75                  80  


Glu Ala Val Arg Asp Leu Cys Ser Lys Leu Ala Val Ala Glu Gln Glu 
                85                  90                  95      


Met Asn Glu Gln Ala Lys Ala Ile Cys Asp Tyr Ala Thr Glu Met Ser 
            100                 105                 110         


Thr Gln Thr Leu Ser Tyr Asn Phe Ala Lys Glu Ile Glu Thr Asn Ile 
        115                 120                 125             


Phe Gly Gln Ile Leu Thr Cys Leu Arg Gln Gly Val Leu Leu Asn Phe 
    130                 135                 140                 


Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile Arg Asn 
145                 150                 155                 160 


Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asp Thr Ile Lys 
                165                 170                 175     


Ile Val Ser Glu Gly Asp Glu Phe Tyr Leu Arg Trp Phe Ser Gly Leu 
            180                 185                 190         


Arg Phe His Leu Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg Met Ile 
        195                 200                 205             


Val Arg Arg Cys Leu Lys Met Glu Gln Asp Phe Asp Glu Glu Tyr Lys 
    210                 215                 220                 


Ile Ser Asn Ser Ser Ile Gln Val Ala Lys Arg Asp Gly Lys Gln Lys 
225                 230                 235                 240 


Leu Phe Leu Leu Leu Val Val Gln Ile Pro Gln Glu Gln Val Val Leu 
                245                 250                 255     


Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Val Asn Val Pro Ala 
            260                 265                 270         


Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly Asp Arg 
        275                 280                 285             


Glu His Phe Leu Asn Thr Arg Met Gln Phe Gln Arg Arg Tyr Lys Ser 
    290                 295                 300                 


Leu Gln Arg Leu Lys Thr Thr Glu Gly Gly Arg Gly Arg Ala Lys Lys 
305                 310                 315                 320 


Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp Val His 
                325                 330                 335     


Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asn Phe Ala Leu Gln 
            340                 345                 350         


Thr Gln Ala Ala Thr Ile Asn Met Glu Asp Leu Ser Gly Phe Gly Lys 
        355                 360                 365             


Asp Asn Asp Gly Asn Ala Asp Glu Cys Lys Glu Phe Val Leu Arg Asn 
    370                 375                 380                 


Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Val Tyr Lys Ala Ser Lys 
385                 390                 395                 400 


Tyr Gly Ile Arg Val Gln Lys Ile Arg Pro Ala Tyr Thr Ser Lys Thr 
                405                 410                 415     


Cys Ser Trp Cys Gly His Met Gly Phe Arg Glu Gly Val Thr Phe Ile 
            420                 425                 430         


Cys Glu Asn Pro Asp Cys Lys Gln Phe Gly Glu Lys Val His Ala Asp 
        435                 440                 445             


Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Glu Ile Ile Lys Asn 
    450                 455                 460                 


Asp Glu 
465     


<210> 144
<211> 444
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 144
Met Ser Lys Thr Val Thr Lys Thr Val Lys Ile Ala Leu Ile Cys Glu 
1               5                   10                  15      


His Thr Asn Lys Tyr Gly Glu Lys Val Asp Tyr Lys Asp Ile Asn Lys 
            20                  25                  30          


Leu Leu Trp Lys Leu Gln Lys Gln Thr Arg Glu Leu Lys Asn Lys Thr 
        35                  40                  45              


Ile Gln Leu Cys Trp Glu Tyr Asn Asn Phe Ser Cys Asp Tyr Tyr Lys 
    50                  55                  60                  


Glu His His Glu Tyr Pro Asn Met Glu Asp Ile Leu Lys Tyr Lys Arg 
65                  70                  75                  80  


Ile Asn Gly Phe Val Glu Asn Lys Leu Lys Thr Val Asn Asp Leu Tyr 
                85                  90                  95      


Ser Ser Asn Cys Ser Thr Thr Ile Leu Ser Thr Cys Asn Glu Phe Gln 
            100                 105                 110         


Asn Tyr Arg Ser Glu Phe Leu Lys Gly Thr Arg Ser Ile Asn Ser Tyr 
        115                 120                 125             


Lys Ser Asp Gln Pro Leu Asp Leu His Lys Gly Ala Ile Lys Leu Glu 
    130                 135                 140                 


His Asp Gly Lys Asp Phe Tyr Val Ser Leu Lys Leu Leu Lys Arg Ser 
145                 150                 155                 160 


Ala Phe Asn Ala Met Glu Phe Lys Gly Ser Asp Ile Arg Phe Lys Leu 
                165                 170                 175     


Asn Val Lys Asp Lys Asp Lys Ser Thr Leu Lys Ile Leu Glu Ser Cys 
            180                 185                 190         


Tyr Asp Lys Ile Tyr Ser Ile Ser Ala Ser Lys Met Thr Tyr Asp Arg 
        195                 200                 205             


Lys Ala Gly Lys Trp Phe Leu Leu Leu Ala Tyr Ser Phe Thr Pro Ala 
    210                 215                 220                 


Lys Thr Glu Asn Leu Asp Pro Glu Lys Ile Leu Gly Val Asp Leu Gly 
225                 230                 235                 240 


Ile Lys Ile Pro Ile Cys Ala Ser Val Tyr Gly Asp Leu Asp Arg Leu 
                245                 250                 255     


Thr Ile Glu Gly Gly Lys Ile Glu Glu Phe Arg Arg Arg Val Glu Ala 
            260                 265                 270         


Arg Lys Arg Ser Leu Gln Lys Gln Gly Lys Gln Cys Gly Asp Gly Arg 
        275                 280                 285             


Ile Gly His Gly Thr Lys Lys Arg Ile Lys Pro Ile Thr Asp Ile Gly 
    290                 295                 300                 


Asp Lys Ile Ala Arg Phe Arg Asp Thr Glu Asn His Ile Tyr Ser Arg 
305                 310                 315                 320 


Tyr Leu Ile Glu Tyr Ala Val Lys Lys Gly Cys Gly Thr Ile Gln Met 
                325                 330                 335     


Glu Lys Leu Glu Gly Ile Thr Arg Glu Lys Asp Ile Phe Leu Lys Asn 
            340                 345                 350         


Trp Thr Tyr Phe Asp Leu Gln Lys Lys Ile Glu Tyr Lys Ala Lys Glu 
        355                 360                 365             


Lys Gly Ile Lys Val Val Tyr Ile Glu Pro Ala Tyr Thr Ser Lys Arg 
    370                 375                 380                 


Cys Ser Ser Cys Gly Phe Ile Asp Thr Asp Asn Arg Leu Asp Gln Ala 
385                 390                 395                 400 


His Phe Lys Cys Leu Lys Cys Gly Phe Asn Glu Asn Ala Asp Tyr Asn 
                405                 410                 415     


Ala Ser Gln Asn Ile Gly Ile Lys Asn Ile Asp Lys Ile Ile Lys Glu 
            420                 425                 430         


Glu His Lys Ser Ala Ser Asp Lys Leu Thr Ser Glu 
        435                 440                 


<210> 145
<211> 439
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 145
Val Ile Ile Leu Thr Lys Val Val Lys Leu Tyr Leu Ile Ser Glu Gln 
1               5                   10                  15      


Ile Asn Lys Glu Gly Gln Lys Ile Asp Tyr Gln Arg Ile Asn Ser Ile 
            20                  25                  30          


Leu Trp Asp Leu Gln Lys Gln Thr Arg Asp Ile Lys Asn Arg Thr Val 
        35                  40                  45              


Gln Leu Cys Trp Glu Trp Met Asn Phe Ser Ser Asp Tyr Cys Lys Thr 
    50                  55                  60                  


Gln Glu Glu Tyr Pro Lys Glu Arg Asp Ile Leu Gly Tyr Thr Leu Glu 
65                  70                  75                  80  


Gly Tyr Val Tyr Asp Tyr Phe Lys Thr Gly Tyr Asp Leu Tyr Thr Gly 
                85                  90                  95      


Asn Ile Ser Thr Ser Ser Arg Glu Val Cys Ser Ser Phe Lys Asn Val 
            100                 105                 110         


Lys Lys Glu Ile Leu Lys Gly Glu Arg Ser Ile Leu Ser Tyr Lys Ala 
        115                 120                 125             


Asn Gln Pro Leu Asp Leu His Lys Lys Ala Ile Ser Leu Glu Tyr Asp 
    130                 135                 140                 


Asn Phe Asn Phe Phe Val Lys Leu Lys Leu Leu Asn Arg Thr Gly Lys 
145                 150                 155                 160 


Lys Lys Tyr Asp Ile Thr Glu Asp Ile Asn Phe Lys Ile Gln Val Asn 
                165                 170                 175     


Asp Lys Ser Thr Arg Thr Ile Leu Glu Arg Cys Tyr Asp Lys Glu Tyr 
            180                 185                 190         


Lys Ile Ser Gly Ser Lys Leu Ile Tyr Glu Lys Lys Lys Lys Leu Trp 
        195                 200                 205             


Arg Leu Asn Leu Cys Tyr Ser Phe Glu Asn Ser Gln Val Glu Thr Leu 
    210                 215                 220                 


Glu Lys Asp Lys Ile Leu Gly Ile Asp Leu Gly Ile Val Tyr Pro Leu 
225                 230                 235                 240 


Met Ala Ser Ile Tyr Gly Glu Tyr Asp Arg Phe Ser Ile Lys Gly Gly 
                245                 250                 255     


Glu Ile Glu Glu Phe Arg Arg Arg Thr Glu Ala Arg Lys Arg Ser Ile 
            260                 265                 270         


Leu Gln Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Arg 
        275                 280                 285             


Asn Lys Arg Thr Gln Pro Ala Tyr Lys Ile Asn Asp Lys Ile Ala Arg 
    290                 295                 300                 


Phe Arg Asp Thr Ala Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr 
305                 310                 315                 320 


Ala Val Lys Lys Asn Cys Gly Ile Ile Gln Met Glu Asn Leu Thr Gly 
                325                 330                 335     


Ile Ser Asp Asn Thr Asp Cys Phe Leu Lys Asp Trp Ser Tyr Tyr Asp 
            340                 345                 350         


Leu Gln Thr Lys Ile Glu Asn Lys Ala Lys Glu Met Gly Ile Lys Val 
        355                 360                 365             


Val Tyr Ile Lys Ala Gln Tyr Thr Ser Gln Arg Cys Ser Arg Cys Gly 
    370                 375                 380                 


Tyr Ile Asp Val Asn Asn Arg Ile Arg Gln Ala Leu Phe Lys Cys Gln 
385                 390                 395                 400 


Asn Cys Gly Tyr Glu Thr Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile 
                405                 410                 415     


Gly Met Tyr Asp Ile Glu Asn Ile Ile Glu Glu Thr Leu Lys Ile Gln 
            420                 425                 430         


Ser Ala Asn Val Lys Gln Ser 
        435                 


<210> 146
<211> 437
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 146
Met Thr Lys Val Thr Lys Val Tyr Leu Ile Ser Glu Gln Ile Asp Lys 
1               5                   10                  15      


Asp Gly Asn Lys Ile Asp Phe Lys Lys Ile Ser Glu Leu Leu Trp Asn 
            20                  25                  30          


Leu Gln Met Gln Thr Arg Asp Ile Lys Asn Lys Cys Val Gln Leu Cys 
        35                  40                  45              


Trp Glu Trp Leu Asn Phe Ser Ser Asp Tyr Tyr Lys Lys Ser Glu Glu 
    50                  55                  60                  


Tyr Pro Lys Glu Lys Asp Thr Leu Gly Tyr Thr Leu Ser Gly Phe Val 
65                  70                  75                  80  


Tyr Asp Arg Ile Lys Asn Gly Ser Asp Leu Tyr Ser Ser Asn Leu Ser 
                85                  90                  95      


Thr Ser Ser Arg Asp Thr Cys Thr Ala Phe Ser Asn Tyr Lys Lys Glu 
            100                 105                 110         


Met Leu Lys Gly Glu Arg Ser Val Leu Ser Phe Lys Ala Asn Gln Pro 
        115                 120                 125             


Leu Asp Ile His Asn Lys Ala Ile Lys Leu Ser Tyr Glu Asn Gly Asn 
    130                 135                 140                 


Phe Phe Val Ala Leu Lys Met Leu Asn Arg Ala Gly Lys Glu Lys Tyr 
145                 150                 155                 160 


Gly Ile Lys Asp Asp Leu Arg Phe Arg Met Gln Val Arg Asp Lys Ser 
                165                 170                 175     


Val Arg Thr Ile Leu Glu Arg Leu Met Asn Asp Glu Tyr Lys Val Ser 
            180                 185                 190         


Ala Ser Lys Leu Met Tyr Asp Lys Lys Lys Lys Leu Trp Lys Leu Asn 
        195                 200                 205             


Leu Cys Tyr Ser Phe Asp Asn His Val Ile Ser Thr Leu Asp Thr Glu 
    210                 215                 220                 


Lys Ile Met Gly Val Asp Leu Gly Val Val Tyr Pro Ile Met Ala Ser 
225                 230                 235                 240 


Val Asn Gly Asp Tyr Ala Arg Phe Ser Ile Lys Gly Gly Glu Ile Glu 
                245                 250                 255     


Ala Phe Arg Ser Arg Val Glu Ala Arg Arg Arg Ser Leu Leu Asn Gln 
            260                 265                 270         


Ser Arg Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Arg Lys Lys Arg 
        275                 280                 285             


Thr Glu Pro Ala Thr Gln Ile Ala Asp Lys Ile Ala Arg Phe Arg Asp 
    290                 295                 300                 


Thr Thr Asn His Lys Tyr Ser Arg Ala Leu Ile Asp Tyr Ala Ile Lys 
305                 310                 315                 320 


Asn Gly Cys Gly Thr Ile Gln Met Glu Lys Leu Thr Gly Ile Thr Ser 
                325                 330                 335     


Ser Ala Glu His Phe Leu Lys Glu Trp Ser Tyr Phe Asp Leu Gln Thr 
            340                 345                 350         


Lys Ile Glu Ser Lys Ala Lys Glu Ala Gly Ile Lys Val Val Tyr Ile 
        355                 360                 365             


Asn Pro Lys Phe Thr Ser Gln Arg Cys Asn Lys Cys Gly Tyr Ile His 
    370                 375                 380                 


Thr Asp Asn Arg Pro Val Gln Ala Arg Phe Cys Cys Gln Lys Cys Gly 
385                 390                 395                 400 


Tyr Glu Glu Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Gly Thr Lys 
                405                 410                 415     


His Ile Asp Val Ile Ile Glu Glu Thr Leu Lys Met Gln Cys Glu Pro 
            420                 425                 430         


Glu Thr Pro Thr Glu 
        435         


<210> 147
<211> 428
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 147
Met Asn Lys Val Val Lys Leu Ala Leu Ile Cys Glu Gln Ser Asp Lys 
1               5                   10                  15      


Asp Asn Ser Pro Val Asp Tyr Lys Lys Ile Asn Glu Ile Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Glu Ile Lys Asn Lys Ala Ile Gln Tyr Cys 
        35                  40                  45              


Trp Glu Tyr Asn Asn Phe Ser Ser Asp Tyr Tyr Lys Lys Phe Asn Glu 
    50                  55                  60                  


Tyr Pro Lys Glu Lys Asp Ile Leu Ser Tyr Thr Leu Val Gly Phe Val 
65                  70                  75                  80  


Asn Asp Lys Phe Lys Thr Gly Asn Asp Leu Tyr Ser Gly Asn Cys Ser 
                85                  90                  95      


Thr Thr Val Arg Asn Ala Cys Thr Glu Phe Lys Asn Ser Lys Lys Glu 
            100                 105                 110         


Leu Ile Lys Gly Ser Arg Ser Ile Ile Asn Tyr Arg Ser Asn Gln Pro 
        115                 120                 125             


Leu Asp Ile His Asn Lys Cys Ile Arg Ile Glu Phe Glu Asn Asn Cys 
    130                 135                 140                 


Phe Tyr Thr Tyr Leu Lys Leu Leu Asn Arg Pro Ala Phe Lys Lys Tyr 
145                 150                 155                 160 


Asn Phe Ala Asn Thr Glu Ile Lys Phe Lys Ile Leu Val Arg Asp Asn 
                165                 170                 175     


Ser Thr Lys Thr Ile Leu Glu Arg Cys Ile Ser Asn Glu Tyr Glu Ile 
            180                 185                 190         


Ala Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Lys Cys Trp Phe Leu 
        195                 200                 205             


Asn Leu Val Tyr Ala Phe Glu Ile Lys Ser Asn Asn Ser Leu Asp Pro 
    210                 215                 220                 


Asn Lys Ile Leu Gly Val Asp Leu Gly Ile His Tyr Pro Ile Cys Ala 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Leu Asp Arg Phe Thr Ile Asp Gly Gly Glu Ile 
                245                 250                 255     


Asp Glu Phe Arg Arg Arg Val Glu Ser Arg Lys Ile Ser Met Leu Lys 
            260                 265                 270         


Gln Gly Lys Asn Cys Gly Asp Gly Arg Ile Gly His Gly Ile Lys Ala 
        275                 280                 285             


Arg Asn Lys Pro Val Tyr Asn Ile Glu Asp Lys Ile Ala Arg Phe Arg 
    290                 295                 300                 


Asp Thr Ala Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr Ala Val 
305                 310                 315                 320 


Lys His Thr Cys Gly Thr Ile Gln Met Glu Asp Leu Thr Gly Ile Thr 
                325                 330                 335     


Asp Ile Ala Asn Arg Phe Leu Lys Asn Trp Ser Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Thr Lys Ile Glu Tyr Lys Ala Lys Glu Ala Gly Ile Asn Ile Val Tyr 
        355                 360                 365             


Ile Asp Pro Lys Asn Thr Ser Arg Arg Cys Ser Lys Cys Gly Tyr Ile 
    370                 375                 380                 


Asp Lys Glu Asn Arg Glu Thr Gln Ser Arg Phe Ile Cys Leu Lys Cys 
385                 390                 395                 400 


Gly Phe Lys Glu Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Gly Ile 
                405                 410                 415     


Lys Asp Ile Asp Lys Leu Ile Lys Glu Asp Val His 
            420                 425             


<210> 148
<211> 443
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 148
Val Thr Leu Leu Val Lys Val Val Lys Ile Tyr Leu Ile Ser Glu Gln 
1               5                   10                  15      


Phe Asp Lys Ala Gly Asn Gln Ile Asp Tyr Lys Glu Val Asn Lys Ile 
            20                  25                  30          


Leu Trp Glu Leu Gln Lys Gln Thr Arg Glu Ala Lys Asn Lys Thr Val 
        35                  40                  45              


Gln Leu Leu Trp Glu Trp Asn Asn Phe Ser Ser Asp Tyr Val Lys Ala 
    50                  55                  60                  


Ser Gly Ile Tyr Pro Lys Ala Lys Asp Ile Phe Gly Tyr Ser Ser Val 
65                  70                  75                  80  


His Gly Gln Ala Asn Lys Glu Leu Arg Thr Lys Leu Ala Leu Asn Ser 
                85                  90                  95      


Ser Asn Leu Ser Thr Thr Thr Met Asp Val Cys Lys Ile Phe Asn Thr 
            100                 105                 110         


Tyr Lys Lys Glu Val Trp Glu Gly Lys Arg Ser Val Pro Ser Tyr Lys 
        115                 120                 125             


Ser Asp Gln Pro Leu Asp Leu His Lys Glu Ser Ile Lys Leu Ile Tyr 
    130                 135                 140                 


Glu Asn Asn Glu Phe Tyr Val Arg Leu Ala Leu Leu Lys Lys Ala Glu 
145                 150                 155                 160 


Phe Ala Lys Tyr Gly Phe Lys Asp Gly Phe Arg Phe Lys Met Gln Val 
                165                 170                 175     


Lys Asp Asn Ser Thr Lys Thr Ile Leu Glu Arg Cys Phe Asp Glu Val 
            180                 185                 190         


Tyr Lys Ile Asn Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Lys Lys 
        195                 200                 205             


Trp Lys Leu Asn Leu Ser Tyr Ser Phe Asp Asn Lys Asn Ile Ser Glu 
    210                 215                 220                 


Leu Asp Lys Glu Lys Ile Leu Gly Val Asp Val Gly Val Asn Cys Pro 
225                 230                 235                 240 


Leu Val Ala Ser Val Phe Gly Asp Arg Asp Arg Phe Ile Ile Lys Gly 
                245                 250                 255     


Gly Glu Ile Glu Lys Phe Arg Lys Ser Val Glu Ala Arg Arg Arg Ser 
            260                 265                 270         


Met Leu Glu Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly 
        275                 280                 285             


Arg Lys Lys Arg Thr Glu Pro Ala Leu Asn Ile Gly Asp Lys Ile Ala 
    290                 295                 300                 


Arg Phe Arg Asp Thr Thr Asn His Lys Tyr Ser Arg Ala Leu Ile Glu 
305                 310                 315                 320 


Tyr Ala Val Lys Lys Gly Cys Gly Thr Ile Gln Met Glu Lys Leu Thr 
                325                 330                 335     


Gly Ile Thr Ser Lys Ser Asp Arg Phe Leu Lys Asp Trp Thr Tyr Tyr 
            340                 345                 350         


Asp Leu Gln Thr Lys Ile Glu Asn Lys Ala Lys Glu Val Gly Ile Asn 
        355                 360                 365             


Val Val Tyr Ile Ala Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys 
    370                 375                 380                 


Gly Tyr Ile His Lys Asp Asn Arg Pro Asn Gln Ala Lys Phe Arg Cys 
385                 390                 395                 400 


Leu Glu Cys Asp Phe Glu Ser Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
                405                 410                 415     


Ile Gly Ile Lys Asn Ile Asp Lys Ile Ile Glu Lys Asp Leu Gln Lys 
            420                 425                 430         


Gln Glu Ser Glu Val Gln Val Asn Glu Asn Lys 
        435                 440             


<210> 149
<211> 428
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 149
Met Asn Lys Val Val Lys Leu Ala Leu Ile Cys Glu Gln Ser Asp Lys 
1               5                   10                  15      


Asn Asn Ser Pro Val Asp Tyr Lys Lys Val Asn Glu Ile Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Glu Ile Lys Asn Lys Thr Ile Gln Tyr Cys 
        35                  40                  45              


Trp Glu Tyr Tyr Asn Phe Ser Ser Asp Tyr Tyr Lys Lys Phe Asn Lys 
    50                  55                  60                  


Tyr Pro Lys Glu Lys Asp Ile Leu Ser Tyr Thr Leu Trp Gly Phe Ile 
65                  70                  75                  80  


Asn Asp Lys Phe Lys Thr Gly Asn Asp Leu Tyr Ser Gly Asn Cys Ser 
                85                  90                  95      


Ala Thr Thr Lys Lys Val Ile Lys Glu Phe Lys Asn Ser Lys Lys Glu 
            100                 105                 110         


Leu Ile Arg Gly Ser Arg Ser Ile Ile Asn Tyr Lys Ser Asn Gln Pro 
        115                 120                 125             


Leu Asn Ile His Asn Lys Cys Ile His Leu Gln Phe Lys Asn Asn Asn 
    130                 135                 140                 


Phe Tyr Val Ser Ile Asn Leu Leu Asn Arg Arg Ser Phe Lys Lys Tyr 
145                 150                 155                 160 


Asn Phe Ala Asn Thr Ala Ile Lys Phe Lys Ile Leu Val Arg Asp Asn 
                165                 170                 175     


Ser Thr Lys Ala Ile Leu Glu Arg Cys Ile Ser Asn Glu Tyr Lys Ile 
            180                 185                 190         


Ser Glu Ser Gln Leu Ile Tyr Asn Lys Lys Lys Lys Cys Trp Phe Leu 
        195                 200                 205             


Asn Leu Ser Tyr Ala Phe Glu Ile Lys Ser Asn Asn Ser Leu Asp Pro 
    210                 215                 220                 


Asn Lys Ile Leu Gly Val Asp Leu Gly Ile His Tyr Pro Ile Cys Ala 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Leu Asp Arg Phe Thr Ile Asp Gly Gly Glu Ile 
                245                 250                 255     


Asp Glu Phe Arg Arg Arg Val Glu Ser Arg Lys Ile Ser Met Leu Lys 
            260                 265                 270         


Gln Gly Lys Asn Cys Gly Asp Gly Arg Ile Gly His Gly Ile Lys Ala 
        275                 280                 285             


Arg Asn Lys Pro Val Tyr Asn Ile Glu Asp Lys Ile Ala Arg Phe Arg 
    290                 295                 300                 


Asp Thr Ala Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr Ala Val 
305                 310                 315                 320 


Lys Asn Asn Cys Gly Thr Ile Gln Met Glu Asp Leu Thr Gly Ile Thr 
                325                 330                 335     


Asp Asn Ala Asn Arg Phe Leu Lys Asn Trp Ser Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Thr Lys Ile Glu Tyr Lys Ala Lys Glu Ala Ser Ile Asn Val Val Tyr 
        355                 360                 365             


Ile Asn Pro Glu Asn Thr Ser Arg Arg Cys Ser Lys Cys Gly Tyr Ile 
    370                 375                 380                 


Asp Lys Glu Asn Arg Lys Thr Gln Ser Ser Phe Ile Cys Leu Lys Cys 
385                 390                 395                 400 


Gly Phe Lys Glu Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ser Ile 
                405                 410                 415     


Lys Asp Ile Asp Lys Leu Ile Lys Glu Asp Val His 
            420                 425             


<210> 150
<211> 443
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 150
Val Thr Leu Leu Val Lys Val Val Lys Ile His Leu Ile Ser Glu Gln 
1               5                   10                  15      


Phe Asp Lys Ala Gly Asn Arg Ile Asp Tyr Glu Glu Val Asn Lys Ile 
            20                  25                  30          


Leu Trp Glu Leu Gln Lys Gln Thr Arg Glu Ala Lys Asn Lys Thr Val 
        35                  40                  45              


Gln Leu Leu Trp Glu Trp Asn Asn Phe Ser Ser Asp Tyr Val Lys Ala 
    50                  55                  60                  


Ser Gly Ile Tyr Pro Lys Ala Lys Asp Ile Phe Gly Tyr Ser Ser Val 
65                  70                  75                  80  


His Gly Gln Ala Asn Lys Glu Leu Arg Thr Lys Leu Ala Leu Asn Ser 
                85                  90                  95      


Ser Asn Leu Ser Thr Thr Thr Met Asp Val Cys Lys Asn Phe Asn Thr 
            100                 105                 110         


Tyr Lys Lys Glu Val Trp Lys Gly Lys Arg Ser Val Pro Ser Tyr Lys 
        115                 120                 125             


Ser Asp Gln Pro Leu Asp Leu His Lys Asp Ser Ile Lys Leu Ile Tyr 
    130                 135                 140                 


Glu Asn Asn Gln Phe Tyr Val Arg Leu Ala Leu Leu Lys Lys Ala Glu 
145                 150                 155                 160 


Phe Ala Lys Tyr Gly Phe Lys Asp Gly Phe His Phe Lys Met Gln Val 
                165                 170                 175     


Lys Asp Asn Ser Thr Lys Thr Ile Leu Glu Arg Cys Phe Asp Glu Val 
            180                 185                 190         


Tyr Lys Ile Asn Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Lys Lys 
        195                 200                 205             


Trp Lys Leu Asn Leu Ser Tyr Ser Phe Asp Asn Lys Asn Ile Ser Glu 
    210                 215                 220                 


Leu Asp Lys Glu Lys Ile Leu Gly Val Asp Val Gly Val Ser Tyr Pro 
225                 230                 235                 240 


Leu Val Ala Ser Val Phe Gly Asp Arg Asp Arg Phe Lys Ile Lys Gly 
                245                 250                 255     


Gly Glu Ile Glu Lys Phe Arg Lys Ser Val Glu Ala Arg Arg Arg Ser 
            260                 265                 270         


Met Leu Glu Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly 
        275                 280                 285             


Arg Lys Lys Arg Thr Glu Pro Ala Leu Asn Ile Gly Asp Lys Ile Ala 
    290                 295                 300                 


Arg Phe Arg Asp Thr Thr Asn His Lys Tyr Ser Arg Ala Leu Ile Glu 
305                 310                 315                 320 


Tyr Ala Val Lys Lys Gly Cys Gly Thr Ile Gln Met Glu Lys Leu Thr 
                325                 330                 335     


Gly Ile Thr Ser Lys Ala Asp Arg Phe Leu Lys Asp Trp Thr Tyr Tyr 
            340                 345                 350         


Asp Leu Gln Thr Lys Ile Glu Asn Lys Ala Lys Glu Val Gly Ile Asn 
        355                 360                 365             


Val Val Tyr Ile Ala Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys 
    370                 375                 380                 


Gly Tyr Ile His Lys Asp Asn Arg Pro Asn Gln Ala Lys Phe Arg Cys 
385                 390                 395                 400 


Leu Glu Cys Asp Phe Glu Ser Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
                405                 410                 415     


Ile Gly Ile Lys Asn Ile Asp Lys Ile Ile Glu Lys Asp Leu Gln Lys 
            420                 425                 430         


Gln Glu Ser Glu Val Gln Val Asn Glu Asn Lys 
        435                 440             


<210> 151
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 151
Leu Ile Trp Lys Asp Ala Leu Gly Gly Ile Ile Leu Thr Lys Ile Val 
1               5                   10                  15      


Lys Leu Tyr Leu Ile Ser Glu Gln Ile Asp Lys Asp Gly Asn Arg Val 
            20                  25                  30          


Asp Tyr Lys Glu Ile Asn Ser Ile Leu Trp Asn Leu Gln Lys Gln Thr 
        35                  40                  45              


Arg Asp Ile Lys Asn Lys Thr Val Gln Leu Cys Trp Glu Trp Met Asn 
    50                  55                  60                  


Phe Ser Ser Asp Tyr Tyr Lys Lys Asn Glu Leu Tyr Pro Asn Glu Lys 
65                  70                  75                  80  


Glu Ile Leu Asn Leu Thr Leu Arg Gly Tyr Ala Tyr Asp His Phe Lys 
                85                  90                  95      


Gln Gly Tyr Asp Leu Tyr Ser Ser Asn Ile Ser Val Leu Thr Glu Ala 
            100                 105                 110         


Val Cys Gly Ala Phe Lys Asn Ala Lys Lys Glu Met Leu Asn Gly Glu 
        115                 120                 125             


Lys Ser Val Leu Ser Tyr Lys Ala Glu Gln Pro Leu Asp Ile His Lys 
    130                 135                 140                 


Lys Cys Ile Lys Leu Glu Tyr Asp Lys Asn Phe Tyr Val Lys Leu Lys 
145                 150                 155                 160 


Met Leu Asn Lys Ala Gly Lys Lys Lys Tyr Gly Ile Glu Asp Asp Leu 
                165                 170                 175     


Asn Phe Lys Ile Gln Val Glu Asp Lys Ser Thr Arg Thr Ile Leu Glu 
            180                 185                 190         


Arg Cys Ile Asp Gly Glu Tyr Val Val Ser Gly Ser Lys Leu Ile Tyr 
        195                 200                 205             


Asp Lys Lys Lys Lys Leu Trp Lys Leu Asn Leu Cys Tyr Ser Phe Lys 
    210                 215                 220                 


Ala Asn Glu Ile Glu Ser Leu Asp Lys Asn Lys Ile Leu Gly Ile Asp 
225                 230                 235                 240 


Leu Gly Ile Ala Cys Pro Leu Met Ala Ser Val Asn Gly Glu Phe Asp 
                245                 250                 255     


Arg Phe Ser Ile Lys Gly Gly Glu Ile Glu Thr Phe Arg Lys Arg Ile 
            260                 265                 270         


Glu Ala Arg Lys Arg Ser Val Leu His Gln Thr Lys Tyr Cys Gly Asp 
        275                 280                 285             


Gly Arg Ile Gly His Gly Arg Asn Lys Arg Thr Glu Pro Ala Tyr Lys 
    290                 295                 300                 


Ile Asn Asp Lys Ile Ala Arg Phe Arg Asp Thr Ala Asn His Lys Tyr 
305                 310                 315                 320 


Ser Arg Ala Leu Ile Asp Tyr Ala Ile Arg Lys Asn Cys Gly Met Ile 
                325                 330                 335     


Gln Met Glu Asn Leu Thr Gly Ile Ser Asp Lys Lys Glu His Phe Leu 
            340                 345                 350         


Lys Glu Trp Ser Tyr Tyr Asp Leu Gln Thr Lys Ile Glu Asn Lys Ala 
        355                 360                 365             


Lys Glu Lys Gly Ile Lys Ile Val Tyr Ile Asn Pro Glu Tyr Thr Ser 
    370                 375                 380                 


Gln Arg Cys Ser Lys Cys Gly Tyr Ile Asp Ala Asn Asn Arg Glu Leu 
385                 390                 395                 400 


Arg Ala Val Phe Lys Cys Gln Lys Cys Gly Phe Glu Ala Asp Ala Asp 
                405                 410                 415     


Tyr Asn Ala Ser Gln Asn Ile Gly Ile Lys Asn Ile Glu Asp Ile Ile 
            420                 425                 430         


Glu Asn Thr Leu Lys Ile Ser Ser Ala Asn Glu Lys Gln Thr Lys Asn 
        435                 440                 445             


Thr 
    


<210> 152
<211> 462
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 152
Val Phe Tyr Ser Thr Phe Leu Cys Tyr Ile Leu Thr Lys Tyr Ile Asp 
1               5                   10                  15      


Phe Ser Ala Asn Glu Cys Tyr Asn Ile Asn Thr Ser Ser Glu Val Lys 
            20                  25                  30          


Gln Leu Met Asn Lys Val Val Lys Leu Ala Leu Ile Cys Glu Gln Ser 
        35                  40                  45              


Asp Lys Asp Asn Ser Pro Val Asp Tyr Lys Lys Ile Asn Glu Ile Leu 
    50                  55                  60                  


Trp Glu Leu Gln Lys Gln Thr Arg Glu Ile Lys Asn Lys Ala Ile Gln 
65                  70                  75                  80  


Tyr Cys Trp Glu Tyr Asn Asn Phe Ser Ser Asp Tyr Tyr Lys Lys Phe 
                85                  90                  95      


Asn Glu Tyr Pro Lys Glu Lys Asp Ile Leu Ser Tyr Thr Leu Val Gly 
            100                 105                 110         


Phe Val Asn Asp Lys Phe Lys Thr Gly Asn Asp Leu Tyr Ser Gly Asn 
        115                 120                 125             


Cys Ser Thr Thr Val Arg Asn Ala Cys Thr Glu Phe Lys Asn Ser Lys 
    130                 135                 140                 


Lys Glu Leu Ile Lys Gly Ser Arg Ser Ile Ile Asn Tyr Arg Ser Asn 
145                 150                 155                 160 


Gln Pro Leu Asp Ile His Asn Lys Cys Ile Arg Ile Glu Phe Glu Asn 
                165                 170                 175     


Asn Cys Phe Tyr Thr Tyr Leu Lys Leu Leu Asn Arg Pro Ala Phe Lys 
            180                 185                 190         


Lys Tyr Asn Phe Ala Asn Thr Glu Ile Lys Phe Lys Ile Leu Val Arg 
        195                 200                 205             


Asp Asn Ser Thr Lys Thr Ile Leu Glu Arg Cys Ile Ser Asn Glu Tyr 
    210                 215                 220                 


Glu Ile Ala Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Lys Cys Trp 
225                 230                 235                 240 


Phe Leu Asn Leu Val Tyr Ala Phe Glu Ile Lys Ser Asn Asn Ser Leu 
                245                 250                 255     


Asp Pro Asn Lys Ile Leu Gly Val Asp Leu Gly Ile His Tyr Pro Ile 
            260                 265                 270         


Cys Ala Ser Val Tyr Gly Ser Leu Asp Arg Phe Thr Ile Asp Gly Gly 
        275                 280                 285             


Glu Ile Asp Glu Phe Arg Arg Arg Val Glu Ser Arg Lys Ile Ser Met 
    290                 295                 300                 


Leu Lys Gln Gly Lys Asn Cys Gly Asp Gly Arg Ile Gly His Gly Ile 
305                 310                 315                 320 


Lys Ala Arg Asn Lys Pro Val Tyr Asn Ile Glu Asp Lys Ile Ala Arg 
                325                 330                 335     


Phe Arg Asp Thr Ala Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr 
            340                 345                 350         


Ala Val Lys His Thr Cys Gly Thr Ile Gln Met Glu Asp Leu Thr Gly 
        355                 360                 365             


Ile Thr Asp Ile Ala Asn Arg Phe Leu Lys Asn Trp Ser Tyr Tyr Asp 
    370                 375                 380                 


Leu Gln Thr Lys Ile Glu Tyr Lys Ala Lys Glu Ala Gly Ile Asn Ile 
385                 390                 395                 400 


Val Tyr Ile Asp Pro Lys Asn Thr Ser Arg Arg Cys Ser Lys Cys Gly 
                405                 410                 415     


Tyr Ile Asp Lys Glu Asn Arg Glu Thr Gln Ser Arg Phe Ile Cys Leu 
            420                 425                 430         


Lys Cys Gly Phe Lys Glu Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile 
        435                 440                 445             


Gly Ile Lys Asp Ile Asp Lys Leu Ile Lys Glu Asp Val His 
    450                 455                 460         


<210> 153
<211> 430
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 153
Leu Ile Ser Glu Gln Ile Asp Lys Asp Gly Asn Arg Val Asp Tyr Lys 
1               5                   10                  15      


Glu Ile Asn Ser Ile Leu Trp Asn Leu Gln Lys Gln Thr Arg Asp Ile 
            20                  25                  30          


Lys Asn Lys Thr Val Gln Leu Cys Trp Glu Trp Met Asn Phe Ser Ser 
        35                  40                  45              


Asp Tyr Tyr Lys Lys Asn Glu Leu Tyr Pro Asn Glu Lys Glu Ile Leu 
    50                  55                  60                  


Asn Leu Thr Leu Arg Gly Tyr Ala Tyr Asp His Phe Lys Gln Gly Tyr 
65                  70                  75                  80  


Asp Leu Tyr Ser Ser Asn Ile Ser Val Leu Thr Glu Ala Val Cys Gly 
                85                  90                  95      


Ala Phe Lys Asn Ala Lys Lys Glu Met Leu Asn Gly Glu Lys Ser Val 
            100                 105                 110         


Leu Ser Tyr Lys Ala Glu Gln Pro Leu Asp Ile His Lys Lys Cys Ile 
        115                 120                 125             


Lys Leu Glu Tyr Asp Lys Asn Phe Tyr Val Lys Leu Lys Met Leu Asn 
    130                 135                 140                 


Lys Ala Gly Lys Lys Lys Tyr Gly Ile Glu Asp Asp Leu Asn Phe Lys 
145                 150                 155                 160 


Ile Gln Val Glu Asp Lys Ser Thr Arg Thr Ile Leu Glu Arg Cys Ile 
                165                 170                 175     


Asp Gly Glu Tyr Val Val Ser Gly Ser Lys Leu Ile Tyr Asp Lys Lys 
            180                 185                 190         


Lys Lys Leu Trp Lys Leu Asn Leu Cys Tyr Ser Phe Lys Ala Asn Glu 
        195                 200                 205             


Ile Glu Ser Leu Asp Lys Asn Lys Ile Leu Gly Ile Asp Leu Gly Ile 
    210                 215                 220                 


Ala Cys Pro Leu Met Ala Ser Val Asn Gly Glu Phe Asp Arg Phe Ser 
225                 230                 235                 240 


Ile Lys Gly Gly Glu Ile Glu Thr Phe Arg Lys Arg Ile Glu Ala Arg 
                245                 250                 255     


Lys Arg Ser Val Leu His Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile 
            260                 265                 270         


Gly His Gly Arg Asn Lys Arg Thr Glu Pro Ala Tyr Lys Ile Asn Asp 
        275                 280                 285             


Lys Ile Ala Arg Phe Arg Asp Thr Ala Asn His Lys Tyr Ser Arg Ala 
    290                 295                 300                 


Leu Ile Asp Tyr Ala Ile Arg Lys Asn Cys Gly Met Ile Gln Met Glu 
305                 310                 315                 320 


Asn Leu Thr Gly Ile Ser Asp Asn Lys Glu His Phe Leu Lys Glu Trp 
                325                 330                 335     


Ser Tyr Tyr Asp Leu Gln Thr Lys Ile Glu Asn Lys Ala Lys Glu Lys 
            340                 345                 350         


Gly Ile Lys Ile Val Tyr Ile Asn Pro Glu Tyr Thr Ser Gln Arg Cys 
        355                 360                 365             


Ser Lys Cys Gly Tyr Ile Asp Ala Asn Asn Arg Glu Leu Arg Ala Val 
    370                 375                 380                 


Phe Lys Cys Gln Asn Cys Gly Phe Glu Ala Asp Ala Asp Tyr Asn Ala 
385                 390                 395                 400 


Ser Gln Asn Ile Gly Ile Lys Asn Ile Glu Asp Ile Ile Glu Asn Thr 
                405                 410                 415     


Leu Lys Ile Ser Ser Ala Asn Glu Lys Gln Thr Lys Asn Thr 
            420                 425                 430 


<210> 154
<211> 429
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 154
Leu Val Lys Val Val Lys Ile Tyr Leu Ile Ser Glu Gln Val Asp Glu 
1               5                   10                  15      


Gln Gly Lys Asp Val Asp Tyr Asn Thr Ile Cys Gly Val Leu Trp Asp 
            20                  25                  30          


Leu Gln Trp Glu Thr Arg Glu Ile Lys Asn Lys Thr Val Gln Leu Cys 
        35                  40                  45              


Trp Glu Trp Ser Gly Phe Ser Ser Asp Tyr Tyr Lys Lys Tyr Gly Glu 
    50                  55                  60                  


Tyr Pro Lys Glu Lys Asn Leu Leu Asp Tyr Thr Met Gly Gly Phe Val 
65                  70                  75                  80  


Tyr Asp Lys Leu Lys Ser Lys Tyr His Leu Tyr Thr Ala Asn Leu Ser 
                85                  90                  95      


Thr Thr Ser Gln Asn Thr Cys Gly Ile Phe Arg Thr Tyr Lys Val Asp 
            100                 105                 110         


Phe Val Lys Gly Asn Arg Ser Val Leu Ser Phe Lys Ala Asp Gln Pro 
        115                 120                 125             


Leu Asp Val His Lys Lys Ser Ile Ser Ile Asp Arg Ile Asp Asp Asn 
    130                 135                 140                 


Tyr Phe Val Lys Leu Lys Leu Leu Asn Lys Ser Gly Ile Gln Lys Tyr 
145                 150                 155                 160 


Gly Ile Arg Asp Asp Phe His Phe Arg Met Leu Val Lys Asp Asn Ser 
                165                 170                 175     


Thr Lys Thr Ile Leu Glu Arg Cys Val Gly Gly Asp Tyr Lys Ala Ala 
            180                 185                 190         


Ala Ser Lys Ile Ile Tyr Asp Lys Lys Lys Lys Met Trp Cys Leu Asn 
        195                 200                 205             


Leu Ser Tyr Glu Phe Asp Val Asn Thr Ala Lys Asp Leu Asn Lys Asn 
    210                 215                 220                 


Arg Ile Leu Gly Ile Asp Ile Gly Ile Val Tyr Pro Val Val Ala Ser 
225                 230                 235                 240 


Val Asn Gly Glu Leu Asp Arg Phe Val Ile Gln Gly Gly Glu Ile Glu 
                245                 250                 255     


Thr Phe Arg Arg Arg Val Glu Asn Arg Lys Lys Ser Leu Leu Lys Gln 
            260                 265                 270         


Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Arg Asn Lys Arg 
        275                 280                 285             


Thr Glu Pro Val Asp Ile Ile Ser Asp Gln Ile Ala Arg Phe Arg Asn 
    290                 295                 300                 


Thr Ala Asn His Lys Tyr Ser Arg Ala Val Ile Asp Tyr Ala Val Arg 
305                 310                 315                 320 


Lys Gln Cys Gly Thr Ile Gln Met Glu Asn Leu Lys Gly Ile Thr Asp 
                325                 330                 335     


Lys Ser Asp Arg Phe Leu Lys Asn Trp Ser Tyr Tyr Asp Leu Gln Gln 
            340                 345                 350         


Lys Ile Glu Tyr Lys Ala Lys Glu Lys Gly Ile Asn Val Val Phe Ile 
        355                 360                 365             


Asn Pro Lys Tyr Thr Ser Gln Arg Cys Ser Arg Cys Gly Tyr Ile Asp 
    370                 375                 380                 


Ser Ala Asn Arg Pro Lys Leu Pro Asn Gln Ser Lys Phe Leu Cys Ile 
385                 390                 395                 400 


Lys Cys Gly Phe Thr Glu Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile 
                405                 410                 415     


Ala Leu Tyr Asn Ile Glu Lys Leu Ile Asp Ala Glu Ala 
            420                 425                 


<210> 155
<211> 707
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 155
Met Ala Asp Thr Pro Thr Leu Phe Thr Gln Phe Leu Arg His His Leu 
1               5                   10                  15      


Pro Gly Gln Arg Phe Arg Lys Asp Ile Leu Lys Gln Ala Gly Arg Ile 
            20                  25                  30          


Leu Ala Asn Lys Gly Glu Asp Ala Thr Ile Ala Phe Leu Arg Gly Lys 
        35                  40                  45              


Ser Glu Glu Ser Pro Pro Asp Phe Gln Pro Pro Val Lys Cys Pro Ile 
    50                  55                  60                  


Ile Ala Cys Ser Arg Pro Leu Thr Glu Trp Pro Ile Tyr Gln Ala Ser 
65                  70                  75                  80  


Val Ala Ile Gln Gly Tyr Val Tyr Gly Gln Ser Leu Ala Glu Phe Glu 
                85                  90                  95      


Ala Ser Asp Pro Gly Cys Ser Lys Asp Gly Leu Leu Gly Trp Phe Asp 
            100                 105                 110         


Lys Thr Gly Val Cys Thr Asp Tyr Phe Ser Val Gln Gly Leu Asn Leu 
        115                 120                 125             


Ile Phe Gln Asn Ala Arg Lys Arg Tyr Ile Gly Val Gln Thr Lys Val 
    130                 135                 140                 


Thr Asn Arg Asn Glu Lys Arg His Lys Lys Leu Lys Arg Ile Asn Ala 
145                 150                 155                 160 


Lys Arg Ile Ala Glu Gly Leu Pro Glu Leu Thr Ser Asp Glu Pro Glu 
                165                 170                 175     


Ser Ala Leu Asp Glu Thr Gly His Leu Ile Asp Pro Pro Gly Leu Asn 
            180                 185                 190         


Thr Asn Ile Tyr Cys Tyr Gln Gln Val Ser Pro Lys Pro Leu Ala Leu 
        195                 200                 205             


Ser Glu Val Asn Gln Leu Pro Thr Ala Tyr Ala Gly Tyr Ser Thr Ser 
    210                 215                 220                 


Gly Asp Asp Pro Ile Gln Pro Met Val Thr Lys Asp Arg Leu Ser Ile 
225                 230                 235                 240 


Ser Lys Gly Gln Pro Gly Tyr Ile Pro Glu His Gln Arg Ala Leu Leu 
                245                 250                 255     


Ser Gln Lys Lys His Arg Arg Met Arg Gly Tyr Gly Leu Lys Ala Arg 
            260                 265                 270         


Ala Leu Leu Val Ile Val Arg Ile Gln Asp Asp Trp Ala Val Ile Asp 
        275                 280                 285             


Leu Arg Ser Leu Leu Arg Asn Ala Tyr Trp Arg Arg Ile Val Gln Thr 
    290                 295                 300                 


Lys Glu Pro Ser Thr Ile Thr Lys Leu Leu Lys Leu Val Thr Gly Asp 
305                 310                 315                 320 


Pro Val Leu Asp Ala Thr Arg Met Val Ala Thr Phe Thr Tyr Lys Pro 
                325                 330                 335     


Gly Ile Val Gln Val Arg Ser Ala Lys Cys Leu Lys Asn Lys Gln Gly 
            340                 345                 350         


Ser Lys Leu Phe Ser Glu Arg Tyr Leu Asn Glu Thr Val Ser Val Thr 
        355                 360                 365             


Ser Ile Asp Leu Gly Ser Asn Asn Leu Val Ala Val Ala Thr Tyr Arg 
    370                 375                 380                 


Leu Val Asn Gly Asn Thr Pro Glu Leu Leu Gln Arg Phe Thr Leu Pro 
385                 390                 395                 400 


Ser His Leu Val Lys Asp Phe Glu Arg Tyr Lys Gln Ala His Asp Thr 
                405                 410                 415     


Leu Glu Asp Ser Ile Gln Lys Thr Ala Val Ala Ser Leu Pro Gln Gly 
            420                 425                 430         


Gln Gln Thr Glu Ile Arg Met Trp Ser Met Tyr Gly Phe Arg Glu Ala 
        435                 440                 445             


Gln Glu Arg Val Cys Gln Glu Leu Gly Leu Ala Asp Gly Ser Ile Pro 
    450                 455                 460                 


Trp Asn Val Met Thr Ala Thr Ser Thr Ile Leu Thr Asp Leu Phe Leu 
465                 470                 475                 480 


Ala Arg Gly Gly Asp Pro Lys Lys Cys Met Phe Thr Ser Glu Pro Lys 
                485                 490                 495     


Lys Lys Lys Asn Ser Lys Gln Val Leu Tyr Lys Ile Arg Asp Arg Ala 
            500                 505                 510         


Trp Ala Lys Met Tyr Arg Thr Leu Leu Ser Lys Glu Thr Arg Glu Ala 
        515                 520                 525             


Trp Asn Lys Ala Leu Trp Gly Leu Lys Arg Gly Ser Pro Asp Tyr Ala 
    530                 535                 540                 


Arg Leu Ser Lys Arg Lys Glu Glu Leu Ala Arg Arg Cys Val Asn Tyr 
545                 550                 555                 560 


Thr Ile Ser Thr Ala Glu Lys Arg Ala Gln Cys Gly Arg Thr Ile Val 
                565                 570                 575     


Ala Leu Glu Asp Leu Asn Ile Gly Phe Phe His Gly Arg Gly Lys Gln 
            580                 585                 590         


Glu Pro Gly Trp Val Gly Leu Phe Thr Arg Lys Lys Glu Asn Arg Trp 
        595                 600                 605             


Leu Met Gln Ala Leu His Lys Ala Phe Leu Glu Leu Ala His His Arg 
    610                 615                 620                 


Gly Tyr His Val Ile Glu Val Asn Pro Ala Tyr Thr Ser Gln Thr Cys 
625                 630                 635                 640 


Pro Val Cys Arg His Cys Asp Pro Asp Asn Arg Asp Gln His Asn Arg 
                645                 650                 655     


Glu Ala Phe His Cys Ile Gly Cys Gly Phe Arg Gly Asn Ala Asp Leu 
            660                 665                 670         


Asp Val Ala Thr His Asn Ile Ala Met Val Ala Ile Thr Gly Glu Ser 
        675                 680                 685             


Leu Lys Arg Ala Arg Gly Ser Val Ala Ser Lys Thr Pro Gln Pro Leu 
    690                 695                 700                 


Ala Ala Glu 
705         


<210> 156
<211> 757
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 156
Met Pro Lys Pro Ala Val Glu Ser Glu Phe Ser Lys Val Leu Lys Lys 
1               5                   10                  15      


His Phe Pro Gly Glu Arg Phe Arg Ser Ser Tyr Met Lys Arg Gly Gly 
            20                  25                  30          


Lys Ile Leu Ala Ala Gln Gly Glu Glu Ala Val Val Ala Tyr Leu Gln 
        35                  40                  45              


Gly Lys Ser Glu Glu Glu Pro Pro Asn Phe Gln Pro Pro Ala Lys Cys 
    50                  55                  60                  


His Val Val Thr Lys Ser Arg Asp Phe Ala Glu Trp Pro Ile Met Lys 
65                  70                  75                  80  


Ala Ser Glu Ala Ile Gln Arg Tyr Ile Tyr Ala Leu Ser Thr Thr Glu 
                85                  90                  95      


Arg Ala Ala Cys Lys Pro Gly Lys Ser Ser Glu Ser His Ala Ala Trp 
            100                 105                 110         


Phe Ala Ala Thr Gly Val Ser Asn His Gly Tyr Ser His Val Gln Gly 
        115                 120                 125             


Leu Asn Leu Ile Phe Asp His Thr Leu Gly Arg Tyr Asp Gly Val Leu 
    130                 135                 140                 


Lys Lys Val Gln Leu Arg Asn Glu Lys Ala Arg Ala Arg Leu Glu Ser 
145                 150                 155                 160 


Ile Asn Ala Ser Arg Ala Asp Glu Gly Leu Pro Glu Ile Lys Ala Glu 
                165                 170                 175     


Glu Glu Glu Val Ala Thr Asn Glu Thr Gly His Leu Leu Gln Pro Pro 
            180                 185                 190         


Gly Ile Asn Pro Ser Phe Tyr Val Tyr Gln Thr Ile Ser Pro Gln Ala 
        195                 200                 205             


Tyr Arg Pro Arg Asp Glu Ile Val Leu Pro Pro Glu Tyr Ala Gly Tyr 
    210                 215                 220                 


Val Arg Asp Pro Asn Ala Pro Ile Pro Leu Gly Val Val Arg Asn Arg 
225                 230                 235                 240 


Cys Asp Ile Gln Lys Gly Cys Pro Gly Tyr Ile Pro Glu Trp Gln Arg 
                245                 250                 255     


Glu Ala Gly Thr Ala Ile Ser Pro Lys Thr Gly Lys Ala Val Thr Val 
            260                 265                 270         


Pro Gly Leu Ser Pro Lys Lys Asn Lys Arg Met Arg Arg Tyr Trp Arg 
        275                 280                 285             


Ser Glu Lys Glu Lys Ala Gln Asp Ala Leu Leu Val Thr Val Arg Ile 
    290                 295                 300                 


Gly Thr Asp Trp Val Val Ile Asp Val Arg Gly Leu Leu Arg Asn Ala 
305                 310                 315                 320 


Arg Trp Arg Thr Ile Ala Pro Lys Asp Ile Ser Leu Asn Ala Leu Leu 
                325                 330                 335     


Asp Leu Phe Thr Gly Asp Pro Val Ile Asp Val Arg Arg Asn Ile Val 
            340                 345                 350         


Thr Phe Thr Tyr Thr Leu Asp Ala Cys Gly Thr Tyr Ala Arg Lys Trp 
        355                 360                 365             


Thr Leu Lys Gly Lys Gln Thr Lys Ala Thr Leu Asp Lys Leu Thr Ala 
    370                 375                 380                 


Thr Gln Thr Val Ala Leu Val Ala Ile Asp Leu Gly Gln Thr Asn Pro 
385                 390                 395                 400 


Ile Ser Ala Gly Ile Ser Arg Val Thr Gln Glu Asn Gly Ala Leu Gln 
                405                 410                 415     


Cys Glu Pro Leu Asp Arg Phe Thr Leu Pro Asp Asp Leu Leu Lys Asp 
            420                 425                 430         


Ile Ser Ala Tyr Arg Ile Ala Trp Asp Arg Asn Glu Glu Glu Leu Arg 
        435                 440                 445             


Ala Arg Ser Val Glu Ala Leu Pro Glu Ala Gln Gln Ala Glu Val Arg 
    450                 455                 460                 


Ala Leu Asp Gly Val Ser Lys Glu Thr Ala Arg Thr Gln Leu Cys Ala 
465                 470                 475                 480 


Asp Phe Gly Leu Asp Pro Lys Arg Leu Pro Trp Asp Lys Met Ser Ser 
                485                 490                 495     


Asn Thr Thr Phe Ile Ser Glu Ala Leu Leu Ser Asn Ser Val Ser Arg 
            500                 505                 510         


Asp Gln Val Phe Phe Thr Pro Ala Pro Lys Lys Gly Ala Lys Lys Lys 
        515                 520                 525             


Ala Pro Val Glu Val Met Arg Lys Asp Arg Thr Trp Ala Arg Ala Tyr 
    530                 535                 540                 


Lys Pro Arg Leu Ser Val Glu Ala Gln Lys Leu Lys Asn Glu Ala Leu 
545                 550                 555                 560 


Trp Ala Leu Lys Arg Thr Ser Pro Glu Tyr Leu Lys Leu Ser Arg Arg 
                565                 570                 575     


Lys Glu Glu Leu Cys Arg Arg Ser Ile Asn Tyr Val Ile Glu Lys Thr 
            580                 585                 590         


Arg Arg Arg Thr Gln Cys Gln Ile Val Ile Pro Val Ile Glu Asp Leu 
        595                 600                 605             


Asn Val Arg Phe Phe His Gly Ser Gly Lys Arg Leu Pro Gly Trp Asp 
    610                 615                 620                 


Asn Phe Phe Thr Ala Lys Lys Glu Asn Arg Trp Phe Ile Gln Gly Leu 
625                 630                 635                 640 


His Lys Ala Phe Ser Asp Leu Arg Thr His Arg Ser Phe Tyr Val Phe 
                645                 650                 655     


Glu Val Arg Pro Glu Arg Thr Ser Ile Thr Cys Pro Lys Cys Gly His 
            660                 665                 670         


Cys Glu Val Gly Asn Arg Asp Gly Glu Ala Phe Gln Cys Leu Ser Cys 
        675                 680                 685             


Gly Lys Thr Cys Asn Ala Asp Leu Asp Val Ala Thr His Asn Leu Thr 
    690                 695                 700                 


Gln Val Ala Leu Thr Gly Lys Thr Met Pro Lys Arg Glu Glu Pro Arg 
705                 710                 715                 720 


Asp Ala Gln Gly Thr Ala Pro Ala Arg Lys Thr Lys Lys Ala Ser Lys 
                725                 730                 735     


Ser Lys Ala Pro Pro Ala Glu Arg Glu Asp Gln Thr Pro Ala Gln Glu 
            740                 745                 750         


Pro Ser Gln Thr Ser 
        755         


<210> 157
<211> 765
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 157
Met Tyr Ile Leu Glu Met Ala Asp Leu Lys Ser Glu Pro Ser Leu Leu 
1               5                   10                  15      


Ala Lys Leu Leu Arg Asp Arg Phe Pro Gly Lys Tyr Trp Leu Pro Lys 
            20                  25                  30          


Tyr Trp Lys Leu Ala Glu Lys Lys Arg Leu Thr Gly Gly Glu Glu Ala 
        35                  40                  45              


Ala Cys Glu Tyr Met Ala Asp Lys Gln Leu Asp Ser Pro Pro Pro Asn 
    50                  55                  60                  


Phe Arg Pro Pro Ala Arg Cys Val Ile Leu Ala Lys Ser Arg Pro Phe 
65                  70                  75                  80  


Glu Asp Trp Pro Val His Arg Val Ala Ser Lys Ala Gln Ser Phe Val 
                85                  90                  95      


Ile Gly Leu Ser Glu Gln Gly Phe Ala Ala Leu Arg Ala Ala Pro Pro 
            100                 105                 110         


Ser Thr Ala Asp Ala Arg Arg Asp Trp Leu Arg Ser His Gly Ala Ser 
        115                 120                 125             


Glu Asp Asp Leu Met Ala Leu Glu Ala Gln Leu Leu Glu Thr Ile Met 
    130                 135                 140                 


Gly Asn Ala Ile Ser Leu His Gly Gly Val Leu Lys Lys Ile Asp Asn 
145                 150                 155                 160 


Ala Asn Val Lys Ala Ala Lys Arg Leu Ser Gly Arg Asn Glu Ala Arg 
                165                 170                 175     


Leu Asn Lys Gly Leu Gln Glu Leu Pro Pro Glu Gln Glu Gly Ser Ala 
            180                 185                 190         


Tyr Gly Ala Asp Gly Leu Leu Val Asn Pro Pro Gly Leu Asn Leu Asn 
        195                 200                 205             


Ile Tyr Cys Arg Lys Ser Cys Cys Pro Lys Pro Val Lys Asn Thr Ala 
    210                 215                 220                 


Arg Phe Val Gly His Tyr Pro Gly Tyr Leu Arg Asp Ser Asp Ser Ile 
225                 230                 235                 240 


Leu Ile Ser Gly Thr Met Asp Arg Leu Thr Ile Ile Glu Gly Met Pro 
                245                 250                 255     


Gly His Ile Pro Ala Trp Gln Arg Glu Gln Gly Leu Val Lys Pro Gly 
            260                 265                 270         


Gly Arg Arg Arg Arg Leu Ser Gly Ser Glu Ser Asn Met Arg Gln Lys 
        275                 280                 285             


Val Asp Pro Ser Thr Gly Pro Arg Arg Ser Thr Arg Ser Gly Thr Val 
    290                 295                 300                 


Asn Arg Ser Asn Gln Arg Thr Gly Arg Asn Gly Asp Pro Leu Leu Val 
305                 310                 315                 320 


Glu Ile Arg Met Lys Glu Asp Trp Val Leu Leu Asp Ala Arg Gly Leu 
                325                 330                 335     


Leu Arg Asn Leu Arg Trp Arg Glu Ser Lys Arg Gly Leu Ser Cys Asp 
            340                 345                 350         


His Glu Asp Leu Ser Leu Ser Gly Leu Leu Ala Leu Phe Ser Gly Asp 
        355                 360                 365             


Pro Val Ile Asp Pro Val Arg Asn Glu Val Val Phe Leu Tyr Gly Glu 
    370                 375                 380                 


Gly Ile Ile Pro Val Arg Ser Thr Lys Pro Val Gly Thr Arg Gln Ser 
385                 390                 395                 400 


Lys Lys Leu Leu Glu Arg Gln Ala Ser Met Gly Pro Leu Thr Leu Ile 
                405                 410                 415     


Ser Cys Asp Leu Gly Gln Thr Asn Leu Ile Ala Gly Arg Ala Ser Ala 
            420                 425                 430         


Ile Ser Leu Thr His Gly Ser Leu Gly Val Arg Ser Ser Val Arg Ile 
        435                 440                 445             


Glu Leu Asp Pro Glu Ile Ile Lys Ser Phe Glu Arg Leu Arg Lys Asp 
    450                 455                 460                 


Ala Asp Arg Leu Glu Thr Glu Ile Leu Thr Ala Ala Lys Glu Thr Leu 
465                 470                 475                 480 


Ser Asp Glu Gln Arg Gly Glu Val Asn Ser His Glu Lys Asp Ser Pro 
                485                 490                 495     


Gln Thr Ala Lys Ala Ser Leu Cys Arg Glu Leu Gly Leu His Pro Pro 
            500                 505                 510         


Ser Leu Pro Trp Gly Gln Met Gly Pro Ser Thr Thr Phe Ile Ala Asp 
        515                 520                 525             


Met Leu Ile Ser His Gly Arg Asp Asp Asp Ala Phe Leu Ser His Gly 
    530                 535                 540                 


Glu Phe Pro Thr Leu Glu Lys Arg Lys Lys Phe Asp Lys Arg Phe Cys 
545                 550                 555                 560 


Leu Glu Ser Arg Pro Leu Leu Ser Ser Glu Thr Arg Lys Ala Leu Asn 
                565                 570                 575     


Glu Ser Leu Trp Glu Val Lys Arg Thr Ser Ser Glu Tyr Ala Arg Leu 
            580                 585                 590         


Ser Gln Arg Lys Lys Glu Met Ala Arg Arg Ala Val Asn Phe Val Val 
        595                 600                 605             


Glu Ile Ser Arg Arg Lys Thr Gly Leu Ser Asn Val Ile Val Asn Ile 
    610                 615                 620                 


Glu Asp Leu Asn Val Arg Ile Phe His Gly Gly Gly Lys Gln Ala Pro 
625                 630                 635                 640 


Gly Trp Asp Gly Phe Phe Arg Pro Lys Ser Glu Asn Arg Trp Phe Ile 
                645                 650                 655     


Gln Ala Ile His Lys Ala Phe Ser Asp Leu Ala Ala His His Gly Ile 
            660                 665                 670         


Pro Val Ile Glu Ser Asp Pro Gln Arg Thr Ser Met Thr Cys Pro Glu 
        675                 680                 685             


Cys Gly His Cys Asp Ser Lys Asn Arg Asn Gly Val Arg Phe Leu Cys 
    690                 695                 700                 


Lys Gly Cys Gly Ala Ser Met Asp Ala Asp Phe Asp Ala Ala Cys Arg 
705                 710                 715                 720 


Asn Leu Glu Arg Val Ala Leu Thr Gly Lys Pro Met Pro Lys Pro Ser 
                725                 730                 735     


Thr Ser Cys Glu Arg Leu Leu Ser Ala Thr Thr Gly Lys Val Cys Ser 
            740                 745                 750         


Asp His Ser Leu Ser His Asp Ala Ile Glu Lys Ala Ser 
        755                 760                 765 


<210> 158
<211> 766
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 158
Met Glu Lys Glu Ile Thr Glu Leu Thr Lys Ile Arg Arg Glu Phe Pro 
1               5                   10                  15      


Asn Lys Lys Phe Ser Ser Thr Asp Met Lys Lys Ala Gly Lys Leu Leu 
            20                  25                  30          


Lys Ala Glu Gly Pro Asp Ala Val Arg Asp Phe Leu Asn Ser Cys Gln 
        35                  40                  45              


Glu Ile Ile Gly Asp Phe Lys Pro Pro Val Lys Thr Asn Ile Val Ser 
    50                  55                  60                  


Ile Ser Arg Pro Phe Glu Glu Trp Pro Val Ser Met Val Gly Arg Ala 
65                  70                  75                  80  


Ile Gln Glu Tyr Tyr Phe Ser Leu Thr Lys Glu Glu Leu Glu Ser Val 
                85                  90                  95      


His Pro Gly Thr Ser Ser Glu Asp His Lys Ser Phe Phe Asn Ile Thr 
            100                 105                 110         


Gly Leu Ser Asn Tyr Asn Tyr Thr Ser Val Gln Gly Leu Asn Leu Ile 
        115                 120                 125             


Phe Lys Asn Ala Lys Ala Ile Tyr Asp Gly Thr Leu Val Lys Ala Asn 
    130                 135                 140                 


Asn Lys Asn Lys Lys Leu Glu Lys Lys Phe Asn Glu Ile Asn His Lys 
145                 150                 155                 160 


Arg Ser Leu Glu Gly Leu Pro Ile Ile Thr Pro Asp Phe Glu Glu Pro 
                165                 170                 175     


Phe Asp Glu Asn Gly His Leu Asn Asn Pro Pro Gly Ile Asn Arg Asn 
            180                 185                 190         


Ile Tyr Gly Tyr Gln Gly Cys Ala Ala Lys Val Phe Val Pro Ser Lys 
        195                 200                 205             


His Lys Met Val Ser Leu Pro Lys Glu Tyr Glu Gly Tyr Asn Arg Asp 
    210                 215                 220                 


Pro Asn Leu Ser Leu Ala Gly Phe Arg Asn Arg Leu Glu Ile Pro Glu 
225                 230                 235                 240 


Gly Glu Pro Gly His Val Pro Trp Phe Gln Arg Met Asp Ile Pro Glu 
                245                 250                 255     


Gly Gln Ile Gly His Val Asn Lys Ile Gln Arg Phe Asn Phe Val His 
            260                 265                 270         


Gly Lys Asn Ser Gly Lys Val Lys Phe Ser Asp Lys Thr Gly Arg Val 
        275                 280                 285             


Lys Arg Tyr His His Ser Lys Tyr Lys Asp Ala Thr Lys Pro Tyr Lys 
    290                 295                 300                 


Phe Leu Glu Glu Ser Lys Lys Val Ser Ala Leu Asp Ser Ile Leu Ala 
305                 310                 315                 320 


Ile Ile Thr Ile Gly Asp Asp Trp Val Val Phe Asp Ile Arg Gly Leu 
                325                 330                 335     


Tyr Arg Asn Val Phe Tyr Arg Glu Leu Ala Gln Lys Gly Leu Thr Ala 
            340                 345                 350         


Val Gln Leu Leu Asp Leu Phe Thr Gly Asp Pro Val Ile Asp Pro Lys 
        355                 360                 365             


Lys Gly Val Val Thr Phe Ser Tyr Lys Glu Gly Val Val Pro Val Phe 
    370                 375                 380                 


Ser Gln Lys Ile Val Pro Arg Phe Lys Ser Arg Asp Thr Leu Glu Lys 
385                 390                 395                 400 


Leu Thr Ser Gln Gly Pro Val Ala Leu Leu Ser Val Asp Leu Gly Gln 
                405                 410                 415     


Asn Glu Pro Val Ala Ala Arg Val Cys Ser Leu Lys Asn Ile Asn Asp 
            420                 425                 430         


Lys Ile Thr Leu Asp Asn Ser Cys Arg Ile Ser Phe Leu Asp Asp Tyr 
        435                 440                 445             


Lys Lys Gln Ile Lys Asp Tyr Arg Asp Ser Leu Asp Glu Leu Glu Ile 
    450                 455                 460                 


Lys Ile Arg Leu Glu Ala Ile Asn Ser Leu Glu Thr Asn Gln Gln Val 
465                 470                 475                 480 


Glu Ile Arg Asp Leu Asp Val Phe Ser Ala Asp Arg Ala Lys Ala Asn 
                485                 490                 495     


Thr Val Asp Met Phe Asp Ile Asp Pro Asn Leu Ile Ser Trp Asp Ser 
            500                 505                 510         


Met Ser Asp Ala Arg Val Ser Thr Gln Ile Ser Asp Leu Tyr Leu Lys 
        515                 520                 525             


Asn Gly Gly Asp Glu Ser Arg Val Tyr Phe Glu Ile Asn Asn Lys Arg 
    530                 535                 540                 


Ile Lys Arg Ser Asp Tyr Asn Ile Ser Gln Leu Val Arg Pro Lys Leu 
545                 550                 555                 560 


Ser Asp Ser Thr Arg Lys Asn Leu Asn Asp Ser Ile Trp Lys Leu Lys 
                565                 570                 575     


Arg Thr Ser Glu Glu Tyr Leu Lys Leu Ser Lys Arg Lys Leu Glu Leu 
            580                 585                 590         


Ser Arg Ala Val Val Asn Tyr Thr Ile Arg Gln Ser Lys Leu Leu Ser 
        595                 600                 605             


Gly Ile Asn Asp Ile Val Ile Ile Leu Glu Asp Leu Asp Val Lys Lys 
    610                 615                 620                 


Lys Phe Asn Gly Arg Gly Ile Arg Asp Ile Gly Trp Asp Asn Phe Phe 
625                 630                 635                 640 


Ser Ser Arg Lys Glu Asn Arg Trp Phe Ile Pro Ala Phe His Lys Ala 
                645                 650                 655     


Phe Ser Glu Leu Ser Ser Asn Arg Gly Leu Cys Val Ile Glu Val Asn 
            660                 665                 670         


Pro Ala Trp Thr Ser Ala Thr Cys Pro Asp Cys Gly Phe Cys Ser Lys 
        675                 680                 685             


Glu Asn Arg Asp Gly Ile Asn Phe Thr Cys Arg Lys Cys Gly Val Ser 
    690                 695                 700                 


Tyr His Ala Asp Ile Asp Val Ala Thr Leu Asn Ile Ala Arg Val Ala 
705                 710                 715                 720 


Val Leu Gly Lys Pro Met Ser Gly Pro Ala Asp Arg Glu Arg Leu Gly 
                725                 730                 735     


Asp Thr Lys Lys Pro Arg Val Ala Arg Ser Arg Lys Thr Met Lys Arg 
            740                 745                 750         


Lys Asp Ile Ser Asn Ser Thr Val Glu Ala Met Val Thr Ala 
        755                 760                 765     


<210> 159
<211> 812
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 159
Met Asp Met Leu Asp Thr Glu Thr Asn Tyr Ala Thr Glu Thr Pro Ala 
1               5                   10                  15      


Gln Gln Gln Asp Tyr Ser Pro Lys Pro Pro Lys Lys Ala Gln Arg Ala 
            20                  25                  30          


Pro Lys Gly Phe Ser Lys Lys Ala Arg Pro Glu Lys Lys Pro Pro Lys 
        35                  40                  45              


Pro Ile Thr Leu Phe Thr Gln Lys His Phe Ser Gly Val Arg Phe Leu 
    50                  55                  60                  


Lys Arg Val Ile Arg Asp Ala Ser Lys Ile Leu Lys Leu Ser Glu Ser 
65                  70                  75                  80  


Arg Thr Ile Thr Phe Leu Glu Gln Ala Ile Glu Arg Asp Gly Ser Ala 
                85                  90                  95      


Pro Pro Asp Val Thr Pro Pro Val His Asn Thr Ile Met Ala Val Thr 
            100                 105                 110         


Arg Pro Phe Glu Glu Trp Pro Glu Val Ile Leu Ser Lys Ala Leu Gln 
        115                 120                 125             


Lys His Cys Tyr Ala Leu Thr Lys Lys Ile Lys Ile Lys Thr Trp Pro 
    130                 135                 140                 


Lys Lys Gly Pro Gly Lys Lys Cys Leu Ala Ala Trp Ser Ala Arg Thr 
145                 150                 155                 160 


Lys Ile Pro Leu Ile Pro Gly Gln Val Gln Ala Thr Asn Gly Leu Phe 
                165                 170                 175     


Asp Arg Ile Gly Ser Ile Tyr Asp Gly Val Glu Lys Lys Val Thr Asn 
            180                 185                 190         


Arg Asn Ala Asn Lys Lys Leu Glu Tyr Asp Glu Ala Ile Lys Glu Gly 
        195                 200                 205             


Arg Asn Pro Ala Val Pro Glu Tyr Glu Thr Ala Tyr Asn Ile Asp Gly 
    210                 215                 220                 


Thr Leu Ile Asn Lys Pro Gly Tyr Asn Pro Asn Leu Tyr Ile Thr Gln 
225                 230                 235                 240 


Ser Arg Thr Pro Arg Leu Ile Thr Glu Ala Asp Arg Pro Leu Val Glu 
                245                 250                 255     


Lys Ile Leu Trp Gln Met Val Glu Lys Lys Thr Gln Ser Arg Asn Gln 
            260                 265                 270         


Ala Arg Arg Ala Arg Leu Glu Lys Ala Ala His Leu Gln Gly Leu Pro 
        275                 280                 285             


Val Pro Lys Phe Val Pro Glu Lys Val Asp Arg Ser Gln Lys Ile Glu 
    290                 295                 300                 


Ile Arg Ile Ile Asp Pro Leu Asp Lys Ile Glu Pro Tyr Met Pro Gln 
305                 310                 315                 320 


Asp Arg Met Ala Ile Lys Ala Ser Gln Asp Gly His Val Pro Tyr Trp 
                325                 330                 335     


Gln Arg Pro Phe Leu Ser Lys Arg Arg Asn Arg Arg Val Arg Ala Gly 
            340                 345                 350         


Trp Gly Lys Gln Val Ser Ser Ile Gln Ala Trp Leu Thr Gly Ala Leu 
        355                 360                 365             


Leu Val Ile Val Arg Leu Gly Asn Glu Ala Phe Leu Ala Asp Ile Arg 
    370                 375                 380                 


Gly Ala Leu Arg Asn Ala Gln Trp Arg Lys Leu Leu Lys Pro Asp Ala 
385                 390                 395                 400 


Thr Tyr Gln Ser Leu Phe Asn Leu Phe Thr Gly Asp Pro Val Val Asn 
                405                 410                 415     


Thr Arg Thr Asn His Leu Thr Met Ala Tyr Arg Glu Gly Val Val Asn 
            420                 425                 430         


Ile Val Lys Ser Arg Ser Phe Lys Gly Arg Gln Thr Arg Glu His Leu 
        435                 440                 445             


Leu Thr Leu Leu Gly Gln Gly Lys Thr Val Ala Gly Val Ser Phe Asp 
    450                 455                 460                 


Leu Gly Gln Lys His Ala Ala Gly Leu Leu Ala Ala His Phe Gly Leu 
465                 470                 475                 480 


Gly Glu Asp Gly Asn Pro Val Phe Thr Pro Ile Gln Ala Cys Phe Leu 
                485                 490                 495     


Pro Gln Arg Tyr Leu Asp Ser Leu Thr Asn Tyr Arg Asn Arg Tyr Asp 
            500                 505                 510         


Ala Leu Thr Leu Asp Met Arg Arg Gln Ser Leu Leu Ala Leu Thr Pro 
        515                 520                 525             


Ala Gln Gln Gln Glu Phe Ala Asp Ala Gln Arg Asp Pro Gly Gly Gln 
    530                 535                 540                 


Ala Lys Arg Ala Cys Cys Leu Lys Leu Asn Leu Asn Pro Asp Glu Ile 
545                 550                 555                 560 


Arg Trp Asp Leu Val Ser Gly Ile Ser Thr Met Ile Ser Asp Leu Tyr 
                565                 570                 575     


Ile Glu Arg Gly Gly Asp Pro Arg Asp Val His Gln Gln Val Glu Thr 
            580                 585                 590         


Lys Pro Lys Gly Lys Arg Lys Ser Glu Ile Arg Ile Leu Lys Ile Arg 
        595                 600                 605             


Asp Gly Lys Trp Ala Tyr Asp Phe Arg Pro Lys Ile Ala Asp Glu Thr 
    610                 615                 620                 


Arg Lys Ala Gln Arg Glu Gln Leu Trp Lys Leu Gln Lys Ala Ser Ser 
625                 630                 635                 640 


Glu Phe Glu Arg Leu Ser Arg Tyr Lys Ile Asn Ile Ala Arg Ala Ile 
                645                 650                 655     


Ala Asn Trp Ala Leu Gln Trp Gly Arg Glu Leu Ser Gly Cys Asp Ile 
            660                 665                 670         


Val Ile Pro Val Leu Glu Asp Leu Asn Val Gly Ser Lys Phe Phe Asp 
        675                 680                 685             


Gly Lys Gly Lys Trp Leu Leu Gly Trp Asp Asn Arg Phe Thr Pro Lys 
    690                 695                 700                 


Lys Glu Asn Arg Trp Phe Ile Lys Val Leu His Lys Ala Val Ala Glu 
705                 710                 715                 720 


Leu Ala Pro His Arg Gly Val Pro Val Tyr Glu Val Met Pro His Arg 
                725                 730                 735     


Thr Ser Met Thr Cys Pro Ala Cys His Tyr Cys His Pro Thr Asn Arg 
            740                 745                 750         


Glu Gly Asp Arg Phe Glu Cys Gln Ser Cys His Val Val Lys Asn Thr 
        755                 760                 765             


Asp Arg Asp Val Ala Pro Tyr Asn Ile Leu Arg Val Ala Val Glu Gly 
    770                 775                 780                 


Lys Thr Leu Asp Arg Trp Gln Ala Glu Lys Lys Pro Gln Ala Glu Pro 
785                 790                 795                 800 


Asp Arg Pro Met Ile Leu Ile Asp Asn Gln Glu Ser 
                805                 810         


<210> 160
<211> 812
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 160
Met Asp Met Leu Asp Thr Glu Thr Asn Tyr Ala Thr Glu Thr Pro Ala 
1               5                   10                  15      


Gln Gln Gln Asp Tyr Ser Pro Lys Pro Pro Lys Lys Ala Gln Arg Ala 
            20                  25                  30          


Pro Lys Gly Phe Ser Lys Lys Ala Arg Pro Glu Lys Lys Pro Pro Lys 
        35                  40                  45              


Pro Ile Thr Leu Phe Thr Gln Lys His Phe Ser Gly Val Arg Phe Leu 
    50                  55                  60                  


Lys Arg Val Ile Arg Asp Ala Ser Lys Ile Leu Lys Leu Ser Glu Ser 
65                  70                  75                  80  


Arg Thr Ile Thr Phe Leu Glu Gln Ala Ile Glu Arg Asp Gly Ser Ala 
                85                  90                  95      


Pro Pro Asp Val Thr Pro Pro Val His Asn Thr Ile Met Ala Val Thr 
            100                 105                 110         


Arg Pro Phe Glu Glu Trp Pro Glu Val Ile Leu Ser Lys Ala Leu Gln 
        115                 120                 125             


Lys His Cys Tyr Ala Leu Thr Lys Lys Ile Lys Ile Lys Thr Trp Pro 
    130                 135                 140                 


Lys Lys Gly Pro Gly Lys Lys Cys Leu Ala Ala Trp Ser Ala Arg Thr 
145                 150                 155                 160 


Lys Ile Pro Leu Ile Pro Gly Gln Val Gln Ala Thr Asn Gly Leu Phe 
                165                 170                 175     


Asp Arg Ile Gly Ser Ile Tyr Asp Gly Val Glu Lys Lys Val Thr Asn 
            180                 185                 190         


Arg Asn Ala Asn Lys Lys Leu Glu Tyr Asp Glu Ala Ile Lys Glu Gly 
        195                 200                 205             


Arg Asn Pro Ala Val Pro Glu Tyr Glu Thr Ala Tyr Asn Ile Asp Gly 
    210                 215                 220                 


Thr Leu Ile Asn Lys Pro Gly Tyr Asn Pro Asn Leu Tyr Ile Thr Gln 
225                 230                 235                 240 


Ser Arg Thr Pro Arg Leu Ile Thr Glu Ala Asp Arg Pro Leu Val Glu 
                245                 250                 255     


Lys Ile Leu Trp Gln Met Val Glu Lys Lys Thr Gln Ser Arg Asn Gln 
            260                 265                 270         


Ala Arg Arg Ala Arg Leu Glu Lys Ala Ala His Leu Gln Gly Leu Pro 
        275                 280                 285             


Val Pro Lys Phe Val Pro Glu Lys Val Asp Arg Ser Gln Lys Ile Glu 
    290                 295                 300                 


Ile Arg Ile Ile Asp Pro Leu Asp Lys Ile Glu Pro Tyr Met Pro Gln 
305                 310                 315                 320 


Asp Arg Met Ala Ile Lys Ala Ser Gln Asp Gly His Val Pro Tyr Trp 
                325                 330                 335     


Gln Arg Pro Phe Leu Ser Lys Arg Arg Asn Arg Arg Val Arg Ala Gly 
            340                 345                 350         


Trp Gly Lys Gln Val Ser Ser Ile Gln Ala Trp Leu Thr Gly Ala Leu 
        355                 360                 365             


Leu Val Ile Val Arg Leu Gly Asn Glu Ala Phe Leu Ala Asp Ile Arg 
    370                 375                 380                 


Gly Ala Leu Arg Asn Ala Gln Trp Arg Lys Leu Leu Lys Pro Asp Ala 
385                 390                 395                 400 


Thr Tyr Gln Ser Leu Phe Asn Leu Phe Thr Gly Asp Pro Val Val Asn 
                405                 410                 415     


Thr Arg Thr Asn His Leu Thr Met Ala Tyr Arg Glu Gly Val Val Asp 
            420                 425                 430         


Ile Val Lys Ser Arg Ser Phe Lys Gly Arg Gln Thr Arg Glu His Leu 
        435                 440                 445             


Leu Thr Leu Leu Gly Gln Gly Lys Thr Val Ala Gly Val Ser Phe Asp 
    450                 455                 460                 


Leu Gly Gln Lys His Ala Ala Gly Leu Leu Ala Ala His Phe Gly Leu 
465                 470                 475                 480 


Gly Glu Asp Gly Asn Pro Val Phe Thr Pro Ile Gln Ala Cys Phe Leu 
                485                 490                 495     


Pro Gln Arg Tyr Leu Asp Ser Leu Thr Asn Tyr Arg Asn Arg Tyr Asp 
            500                 505                 510         


Ala Leu Thr Leu Asp Met Arg Arg Gln Ser Leu Leu Ala Leu Thr Pro 
        515                 520                 525             


Ala Gln Gln Gln Glu Phe Ala Asp Ala Gln Arg Asp Pro Gly Gly Gln 
    530                 535                 540                 


Ala Lys Arg Ala Cys Cys Leu Lys Leu Asn Leu Asn Pro Asp Glu Ile 
545                 550                 555                 560 


Arg Trp Asp Leu Val Ser Gly Ile Ser Thr Met Ile Ser Asp Leu Tyr 
                565                 570                 575     


Ile Glu Arg Gly Gly Asp Pro Arg Asp Val His Gln Gln Val Glu Thr 
            580                 585                 590         


Lys Pro Lys Gly Lys Arg Lys Ser Glu Ile Arg Ile Leu Lys Ile Arg 
        595                 600                 605             


Asp Gly Lys Trp Ala Tyr Asp Phe Arg Pro Lys Ile Ala Asp Glu Thr 
    610                 615                 620                 


Arg Lys Ala Gln Arg Glu Gln Leu Trp Lys Leu Gln Lys Ala Ser Ser 
625                 630                 635                 640 


Glu Phe Glu Arg Leu Ser Arg Tyr Lys Ile Asn Ile Ala Arg Ala Ile 
                645                 650                 655     


Ala Asn Trp Ala Leu Gln Trp Gly Arg Glu Leu Ser Gly Cys Asp Ile 
            660                 665                 670         


Val Ile Pro Val Leu Glu Asp Leu Asn Val Gly Ser Lys Phe Phe Asp 
        675                 680                 685             


Gly Lys Gly Lys Trp Leu Leu Gly Trp Asp Asn Arg Phe Thr Pro Lys 
    690                 695                 700                 


Lys Glu Asn Arg Trp Phe Ile Lys Val Leu His Lys Ala Val Ala Glu 
705                 710                 715                 720 


Leu Ala Pro His Lys Gly Val Pro Val Tyr Glu Val Met Pro His Arg 
                725                 730                 735     


Thr Ser Met Thr Cys Pro Ala Cys His Tyr Cys His Pro Thr Asn Arg 
            740                 745                 750         


Glu Gly Asp Arg Phe Glu Cys Gln Ser Cys His Val Val Lys Asn Thr 
        755                 760                 765             


Asp Arg Asp Val Ala Pro Tyr Asn Ile Leu Arg Val Ala Val Glu Gly 
    770                 775                 780                 


Lys Thr Leu Asp Arg Trp Gln Ala Glu Lys Lys Pro Gln Ala Glu Pro 
785                 790                 795                 800 


Asp Arg Pro Met Ile Leu Ile Asp Asn Gln Glu Ser 
                805                 810         


<210> 161
<211> 793
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 161
Met Ser Ser Leu Pro Thr Pro Leu Glu Leu Leu Lys Gln Lys His Ala 
1               5                   10                  15      


Asp Leu Phe Lys Gly Leu Gln Phe Ser Ser Lys Asp Asn Lys Met Ala 
            20                  25                  30          


Gly Lys Val Leu Lys Lys Asp Gly Glu Glu Ala Ala Leu Ala Phe Leu 
        35                  40                  45              


Ser Glu Arg Gly Val Ser Arg Gly Glu Leu Pro Asn Phe Arg Pro Pro 
    50                  55                  60                  


Ala Lys Thr Leu Val Val Ala Gln Ser Arg Pro Phe Glu Glu Phe Pro 
65                  70                  75                  80  


Ile Tyr Arg Val Ser Glu Ala Ile Gln Leu Tyr Val Tyr Ser Leu Ser 
                85                  90                  95      


Val Lys Glu Leu Glu Thr Val Pro Ser Gly Ser Ser Thr Lys Lys Glu 
            100                 105                 110         


His Gln Arg Phe Phe Gln Asp Ser Ser Val Pro Asp Phe Gly Tyr Thr 
        115                 120                 125             


Ser Val Gln Gly Leu Asn Lys Ile Phe Gly Leu Ala Arg Gly Ile Tyr 
    130                 135                 140                 


Leu Gly Val Ile Thr Arg Gly Glu Asn Gln Leu Gln Lys Ala Lys Ser 
145                 150                 155                 160 


Lys His Glu Ala Leu Asn Lys Lys Arg Arg Ala Ser Gly Glu Ala Glu 
                165                 170                 175     


Thr Glu Phe Asp Pro Thr Pro Tyr Glu Tyr Met Thr Pro Glu Arg Lys 
            180                 185                 190         


Leu Ala Lys Pro Pro Gly Val Asn His Ser Ile Met Cys Tyr Val Asp 
        195                 200                 205             


Ile Ser Val Asp Glu Phe Asp Phe Arg Asn Pro Asp Gly Ile Val Leu 
    210                 215                 220                 


Pro Ser Glu Tyr Ala Gly Tyr Cys Arg Glu Ile Asn Thr Ala Ile Glu 
225                 230                 235                 240 


Lys Gly Thr Val Asp Arg Leu Gly His Leu Lys Gly Gly Pro Gly Tyr 
                245                 250                 255     


Ile Pro Gly His Gln Arg Lys Glu Ser Thr Thr Glu Gly Pro Lys Ile 
            260                 265                 270         


Asn Phe Arg Lys Gly Arg Ile Arg Arg Ser Tyr Thr Ala Leu Tyr Ala 
        275                 280                 285             


Lys Arg Asp Ser Arg Arg Val Arg Gln Gly Lys Leu Ala Leu Pro Ser 
    290                 295                 300                 


Tyr Arg His His Met Met Arg Leu Asn Ser Asn Ala Glu Ser Ala Ile 
305                 310                 315                 320 


Leu Ala Val Ile Phe Phe Gly Lys Asp Trp Val Val Phe Asp Leu Arg 
                325                 330                 335     


Gly Leu Leu Arg Asn Val Arg Trp Arg Asn Leu Phe Val Asp Gly Ser 
            340                 345                 350         


Thr Pro Ser Thr Leu Leu Gly Met Phe Gly Asp Pro Val Ile Asp Pro 
        355                 360                 365             


Lys Arg Gly Val Val Ala Phe Cys Tyr Lys Glu Gln Ile Val Pro Val 
    370                 375                 380                 


Val Ser Lys Ser Ile Thr Lys Met Val Lys Ala Pro Glu Leu Leu Asn 
385                 390                 395                 400 


Lys Leu Tyr Leu Lys Ser Glu Asp Pro Leu Val Leu Val Ala Ile Asp 
                405                 410                 415     


Leu Gly Gln Thr Asn Pro Val Gly Val Gly Val Tyr Arg Val Met Asn 
            420                 425                 430         


Ala Ser Leu Asp Tyr Glu Val Val Thr Arg Phe Ala Leu Glu Ser Glu 
        435                 440                 445             


Leu Leu Arg Glu Ile Glu Ser Tyr Arg Gln Arg Thr Asn Ala Phe Glu 
    450                 455                 460                 


Ala Gln Ile Arg Ala Glu Thr Phe Asp Ala Met Thr Ser Glu Glu Gln 
465                 470                 475                 480 


Glu Glu Ile Thr Arg Val Arg Ala Phe Ser Ala Ser Lys Ala Lys Glu 
                485                 490                 495     


Asn Val Cys His Arg Phe Gly Met Pro Val Asp Ala Val Asp Trp Ala 
            500                 505                 510         


Thr Met Gly Ser Asn Thr Ile His Ile Ala Lys Trp Val Met Arg His 
        515                 520                 525             


Gly Asp Pro Ser Leu Val Glu Val Leu Glu Tyr Arg Lys Asp Asn Glu 
    530                 535                 540                 


Ile Lys Leu Asp Lys Asn Gly Val Pro Lys Lys Val Lys Leu Thr Asp 
545                 550                 555                 560 


Lys Arg Ile Ala Asn Leu Thr Ser Ile Arg Leu Arg Phe Ser Gln Glu 
                565                 570                 575     


Thr Ser Lys His Tyr Asn Asp Thr Met Trp Glu Leu Arg Arg Lys His 
            580                 585                 590         


Pro Val Tyr Gln Lys Leu Ser Lys Ser Lys Ala Asp Phe Ser Arg Arg 
        595                 600                 605             


Val Val Asn Ser Ile Ile Arg Arg Val Asn His Leu Val Pro Arg Ala 
    610                 615                 620                 


Arg Ile Val Phe Ile Ile Glu Asp Leu Lys Asn Leu Gly Lys Val Phe 
625                 630                 635                 640 


His Gly Ser Gly Lys Arg Glu Leu Gly Trp Asp Ser Tyr Phe Glu Pro 
                645                 650                 655     


Lys Ser Glu Asn Arg Trp Phe Ile Gln Val Leu His Lys Ala Phe Ser 
            660                 665                 670         


Glu Thr Gly Lys His Lys Gly Tyr Tyr Ile Ile Glu Cys Trp Pro Asn 
        675                 680                 685             


Trp Thr Ser Cys Thr Cys Pro Lys Cys Ser Cys Cys Asp Ser Glu Asn 
    690                 695                 700                 


Arg His Gly Glu Val Phe Arg Cys Leu Ala Cys Gly Tyr Thr Cys Asn 
705                 710                 715                 720 


Thr Asp Phe Gly Thr Ala Pro Asp Asn Leu Val Lys Ile Ala Thr Thr 
                725                 730                 735     


Gly Lys Gly Leu Pro Gly Pro Lys Lys Arg Cys Lys Gly Ser Ser Lys 
            740                 745                 750         


Gly Lys Asn Pro Lys Ile Ala Arg Ser Ser Glu Thr Gly Val Ser Val 
        755                 760                 765             


Thr Glu Ser Gly Ala Pro Lys Val Lys Lys Ser Ser Pro Thr Gln Thr 
    770                 775                 780                 


Ser Gln Ser Ser Ser Gln Ser Ala Pro 
785                 790             


<210> 162
<211> 441
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 162
Met Asn Lys Ile Glu Lys Glu Lys Thr Pro Leu Ala Lys Leu Met Asn 
1               5                   10                  15      


Glu Asn Phe Ala Gly Leu Arg Phe Pro Phe Ala Ile Ile Lys Gln Ala 
            20                  25                  30          


Gly Lys Lys Leu Leu Lys Glu Gly Glu Leu Lys Thr Ile Glu Tyr Met 
        35                  40                  45              


Thr Gly Lys Gly Ser Ile Glu Pro Leu Pro Asn Phe Lys Pro Pro Val 
    50                  55                  60                  


Lys Cys Leu Ile Val Ala Lys Arg Arg Asp Leu Lys Tyr Phe Pro Ile 
65                  70                  75                  80  


Cys Lys Ala Ser Cys Glu Ile Gln Ser Tyr Val Tyr Ser Leu Asn Tyr 
                85                  90                  95      


Lys Asp Phe Met Asp Tyr Phe Ser Thr Pro Met Thr Ser Gln Lys Gln 
            100                 105                 110         


His Glu Glu Phe Phe Lys Lys Ser Gly Leu Asn Ile Glu Tyr Gln Asn 
        115                 120                 125             


Val Ala Gly Leu Asn Leu Ile Phe Asn Asn Val Lys Asn Thr Tyr Asn 
    130                 135                 140                 


Gly Val Ile Leu Lys Val Lys Asn Arg Asn Glu Lys Leu Lys Lys Lys 
145                 150                 155                 160 


Ala Ile Lys Asn Asn Tyr Glu Phe Glu Glu Ile Lys Thr Phe Asn Asp 
                165                 170                 175     


Asp Gly Cys Leu Ile Asn Lys Pro Gly Ile Asn Asn Val Ile Tyr Cys 
            180                 185                 190         


Phe Gln Ser Ile Ser Pro Lys Ile Leu Lys Asn Ile Thr His Leu Pro 
        195                 200                 205             


Lys Glu Tyr Asn Asp Tyr Asp Cys Ser Val Asp Arg Asn Ile Ile Gln 
    210                 215                 220                 


Lys Tyr Val Ser Arg Leu Asp Ile Pro Glu Ser Gln Pro Gly His Val 
225                 230                 235                 240 


Pro Glu Trp Gln Arg Lys Leu Pro Glu Phe Asn Asn Thr Asn Asn Pro 
                245                 250                 255     


Arg Arg Arg Arg Lys Trp Tyr Ser Asn Gly Arg Asn Ile Ser Lys Gly 
            260                 265                 270         


Tyr Ser Val Asp Gln Val Asn Gln Ala Lys Ile Glu Asp Ser Leu Leu 
        275                 280                 285             


Ala Gln Ile Lys Ile Gly Glu Asp Trp Ile Ile Leu Asp Ile Arg Gly 
    290                 295                 300                 


Leu Leu Arg Asp Leu Asn Arg Arg Glu Leu Ile Ser Tyr Lys Asn Lys 
305                 310                 315                 320 


Leu Thr Ile Lys Asp Val Leu Gly Phe Phe Ser Asp Tyr Pro Ile Ile 
                325                 330                 335     


Asp Ile Lys Lys Asn Leu Val Thr Phe Cys Tyr Lys Glu Gly Val Ile 
            340                 345                 350         


Gln Val Val Ser Gln Lys Ser Ile Gly Asn Lys Lys Ser Lys Gln Leu 
        355                 360                 365             


Leu Glu Lys Leu Ile Glu Asn Lys Pro Ile Ala Leu Val Ser Ile Asp 
    370                 375                 380                 


Leu Gly Gln Thr Asn Pro Val Ser Val Lys Ile Ser Lys Leu Asn Lys 
385                 390                 395                 400 


Ile Asn Asn Lys Ile Ser Ile Glu Ser Phe Thr Tyr Arg Phe Leu Asn 
                405                 410                 415     


Glu Glu Ile Leu Lys Glu Ile Glu Lys Tyr Arg Lys Asp Tyr Asp Lys 
            420                 425                 430         


Leu Glu Leu Lys Leu Ile Asn Glu Ala 
        435                 440     


<210> 163
<211> 812
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 163
Met Asp Met Leu Asp Thr Glu Thr Asn Tyr Ala Thr Glu Thr Pro Ser 
1               5                   10                  15      


Gln Gln Gln Asp Tyr Ser Pro Lys Pro Pro Lys Lys Asp Arg Arg Ala 
            20                  25                  30          


Pro Lys Gly Phe Ser Lys Lys Ala Arg Pro Glu Lys Lys Pro Pro Lys 
        35                  40                  45              


Pro Ile Thr Leu Phe Thr Gln Lys His Phe Ser Gly Val Arg Phe Leu 
    50                  55                  60                  


Lys Arg Val Ile Arg Asp Ala Ser Lys Ile Leu Lys Leu Ser Glu Ser 
65                  70                  75                  80  


Arg Thr Ile Thr Phe Leu Glu Gln Ala Ile Glu Arg Asp Gly Ser Ala 
                85                  90                  95      


Pro Pro Asp Val Thr Pro Pro Val His Asn Thr Ile Met Ala Val Thr 
            100                 105                 110         


Arg Pro Phe Glu Glu Trp Pro Glu Val Ile Leu Ser Lys Ala Leu Gln 
        115                 120                 125             


Lys His Cys Tyr Ala Leu Thr Lys Lys Ile Lys Ile Lys Thr Trp Pro 
    130                 135                 140                 


Lys Lys Gly Pro Gly Lys Lys Cys Leu Ala Ala Trp Ser Ala Arg Thr 
145                 150                 155                 160 


Lys Ile Pro Leu Ile Pro Gly Gln Val Gln Ala Thr Asn Gly Leu Phe 
                165                 170                 175     


Asp Arg Ile Gly Ser Ile Tyr Asp Gly Val Glu Lys Lys Val Thr Asn 
            180                 185                 190         


Arg Asn Ala Asn Lys Lys Leu Glu Tyr Asp Glu Ala Ile Lys Glu Gly 
        195                 200                 205             


Arg Asn Pro Ala Val Pro Glu Tyr Glu Thr Ala Tyr Asn Ile Asp Gly 
    210                 215                 220                 


Thr Leu Ile Asn Lys Pro Gly Tyr Asn Pro Asn Leu Tyr Ile Thr Gln 
225                 230                 235                 240 


Ser Arg Thr Pro Arg Leu Ile Thr Glu Ala Asp Arg Pro Leu Val Glu 
                245                 250                 255     


Lys Ile Leu Trp Gln Met Val Glu Lys Lys Thr Gln Ser Arg Asn Gln 
            260                 265                 270         


Ala Arg Arg Ala Arg Leu Glu Lys Ala Ala His Leu Gln Gly Leu Pro 
        275                 280                 285             


Val Pro Lys Phe Val Pro Glu Lys Val Asp Arg Ser Gln Lys Ile Glu 
    290                 295                 300                 


Ile Arg Ile Ile Asp Pro Leu Asp Lys Ile Glu Pro Tyr Met Pro Gln 
305                 310                 315                 320 


Asp Arg Met Ala Ile Lys Ala Ser Gln Asp Gly His Val Pro Tyr Trp 
                325                 330                 335     


Gln Arg Pro Phe Leu Ser Lys Arg Arg Asn Arg Arg Val Arg Ala Gly 
            340                 345                 350         


Trp Gly Lys Gln Val Ser Ser Ile Gln Ala Trp Leu Thr Gly Ala Leu 
        355                 360                 365             


Leu Val Ile Val Arg Leu Gly Asn Glu Ala Phe Leu Ala Asp Ile Arg 
    370                 375                 380                 


Gly Ala Leu Arg Asn Ala Gln Trp Arg Lys Leu Leu Lys Pro Asp Ala 
385                 390                 395                 400 


Thr Tyr Gln Ser Leu Phe Asn Leu Phe Thr Gly Asp Pro Val Val Asn 
                405                 410                 415     


Thr Arg Thr Asn His Leu Thr Met Ala Tyr Arg Glu Gly Val Val Asp 
            420                 425                 430         


Ile Val Lys Ser Arg Ser Phe Lys Gly Arg Gln Thr Arg Glu His Leu 
        435                 440                 445             


Leu Thr Leu Leu Gly Gln Gly Lys Thr Val Ala Gly Val Ser Phe Asp 
    450                 455                 460                 


Leu Gly Gln Lys His Ala Ala Gly Leu Leu Ala Ala His Phe Gly Leu 
465                 470                 475                 480 


Gly Glu Asp Gly Asn Pro Val Phe Thr Pro Ile Gln Ala Cys Phe Leu 
                485                 490                 495     


Pro Gln Arg Tyr Leu Asp Ser Leu Thr Asn Tyr Arg Asn Arg Tyr Asp 
            500                 505                 510         


Ala Leu Thr Leu Asp Met Arg Arg Gln Ser Leu Leu Ala Leu Thr Pro 
        515                 520                 525             


Ala Gln Gln Gln Glu Phe Ala Asp Ala Gln Arg Asp Pro Gly Gly Gln 
    530                 535                 540                 


Ala Lys Arg Ala Cys Cys Leu Lys Leu Asn Leu Asn Pro Asp Glu Ile 
545                 550                 555                 560 


Arg Trp Asp Leu Val Ser Gly Ile Ser Thr Met Ile Ser Asp Leu Tyr 
                565                 570                 575     


Ile Glu Arg Gly Gly Asp Pro Arg Asp Val His Gln Gln Val Glu Thr 
            580                 585                 590         


Lys Pro Lys Gly Lys Arg Lys Ser Glu Ile Arg Ile Leu Lys Ile Arg 
        595                 600                 605             


Asp Gly Lys Trp Ala Tyr Asp Phe Arg Pro Lys Ile Ala Asp Glu Thr 
    610                 615                 620                 


Arg Lys Ala Gln Arg Glu Gln Leu Trp Lys Leu Gln Lys Ala Ser Ser 
625                 630                 635                 640 


Glu Phe Glu Arg Leu Ser Arg Tyr Lys Ile Asn Ile Ala Arg Ala Ile 
                645                 650                 655     


Ala Asn Trp Ala Leu Gln Trp Gly Arg Glu Leu Ser Gly Cys Asp Ile 
            660                 665                 670         


Val Ile Pro Val Leu Glu Asp Leu Asn Val Gly Ser Lys Phe Phe Asp 
        675                 680                 685             


Gly Lys Gly Lys Trp Leu Leu Gly Trp Asp Asn Arg Phe Thr Pro Lys 
    690                 695                 700                 


Lys Glu Asn Arg Trp Phe Ile Lys Val Leu His Lys Ala Val Ala Glu 
705                 710                 715                 720 


Leu Ala Pro His Arg Gly Val Pro Val Tyr Glu Val Met Pro His Arg 
                725                 730                 735     


Thr Ser Met Thr Cys Pro Ala Cys His Tyr Cys His Pro Thr Asn Arg 
            740                 745                 750         


Glu Gly Asp Arg Phe Glu Cys Gln Ser Cys His Val Val Lys Asn Thr 
        755                 760                 765             


Asp Arg Asp Val Ala Pro Tyr Asn Ile Leu Arg Val Ala Val Glu Gly 
    770                 775                 780                 


Lys Thr Leu Asp Arg Trp Gln Ala Glu Lys Lys Pro Gln Ala Glu Pro 
785                 790                 795                 800 


Asp Arg Pro Met Ile Leu Ile Asp Asn Gln Glu Ser 
                805                 810         


<210> 164
<211> 812
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 164
Met Asp Met Leu Asp Thr Glu Thr Asn Tyr Ala Thr Glu Thr Pro Ser 
1               5                   10                  15      


Gln Gln Gln Asp Tyr Ser Pro Lys Pro Pro Lys Lys Asp Arg Arg Ala 
            20                  25                  30          


Pro Lys Gly Phe Ser Lys Lys Ala Arg Pro Glu Lys Lys Pro Pro Lys 
        35                  40                  45              


Pro Ile Thr Leu Phe Thr Gln Lys His Phe Ser Gly Val Arg Phe Leu 
    50                  55                  60                  


Lys Arg Val Ile Arg Asp Ala Ser Lys Ile Leu Lys Leu Ser Glu Ser 
65                  70                  75                  80  


Arg Thr Ile Thr Phe Leu Glu Gln Ala Ile Glu Arg Asp Gly Ser Ala 
                85                  90                  95      


Pro Pro Asp Val Thr Pro Pro Val His Asn Thr Ile Met Ala Val Thr 
            100                 105                 110         


Arg Pro Phe Glu Glu Trp Pro Glu Val Ile Leu Ser Lys Ala Leu Gln 
        115                 120                 125             


Lys His Cys Tyr Ala Leu Thr Lys Lys Ile Lys Ile Lys Thr Trp Pro 
    130                 135                 140                 


Lys Lys Gly Pro Gly Lys Lys Cys Leu Ala Ala Trp Ser Ala Arg Thr 
145                 150                 155                 160 


Lys Ile Pro Leu Ile Pro Gly Gln Val Gln Ala Thr Asn Gly Leu Phe 
                165                 170                 175     


Asp Arg Ile Gly Ser Ile Tyr Asp Gly Val Glu Lys Lys Val Thr Asn 
            180                 185                 190         


Arg Asn Ala Asn Lys Lys Leu Glu Tyr Asp Glu Ala Ile Lys Glu Gly 
        195                 200                 205             


Arg Asn Pro Ala Val Pro Glu Tyr Glu Thr Ala Tyr Asn Ile Asp Gly 
    210                 215                 220                 


Thr Leu Ile Asn Lys Pro Gly Tyr Asn Pro Asn Leu Tyr Ile Thr Gln 
225                 230                 235                 240 


Ser Arg Thr Pro Arg Leu Ile Thr Glu Ala Asp Arg Pro Leu Val Glu 
                245                 250                 255     


Lys Ile Leu Trp Gln Met Val Glu Lys Lys Thr Gln Ser Arg Asn Gln 
            260                 265                 270         


Ala Arg Arg Ala Arg Leu Glu Lys Ala Ala His Leu Gln Gly Leu Pro 
        275                 280                 285             


Val Pro Lys Phe Val Pro Glu Lys Val Asp Arg Ser Gln Lys Ile Glu 
    290                 295                 300                 


Ile Arg Ile Ile Asp Pro Leu Asp Lys Ile Glu Pro Tyr Met Pro Gln 
305                 310                 315                 320 


Asp Arg Met Ala Ile Lys Ala Ser Gln Asp Gly His Val Pro Tyr Trp 
                325                 330                 335     


Gln Arg Pro Phe Leu Ser Lys Arg Arg Asn Arg Arg Val Arg Ala Gly 
            340                 345                 350         


Trp Gly Lys Gln Val Ser Ser Ile Gln Ala Trp Leu Thr Gly Ala Leu 
        355                 360                 365             


Leu Val Ile Val Arg Leu Gly Asn Glu Ala Phe Leu Ala Asp Ile Arg 
    370                 375                 380                 


Gly Ala Leu Arg Asn Ala Gln Trp Arg Lys Leu Leu Lys Pro Asp Ala 
385                 390                 395                 400 


Thr Tyr Gln Ser Leu Phe Asn Leu Phe Thr Gly Asp Pro Val Val Asn 
                405                 410                 415     


Thr Arg Thr Asn His Leu Thr Met Ala Tyr Arg Glu Gly Val Val Asn 
            420                 425                 430         


Ile Val Lys Ser Arg Ser Phe Lys Gly Arg Gln Thr Arg Glu His Leu 
        435                 440                 445             


Leu Thr Leu Leu Gly Gln Gly Lys Thr Val Ala Gly Val Ser Phe Asp 
    450                 455                 460                 


Leu Gly Gln Lys His Ala Ala Gly Leu Leu Ala Ala His Phe Gly Leu 
465                 470                 475                 480 


Gly Glu Asp Gly Asn Pro Val Phe Thr Pro Ile Gln Ala Cys Phe Leu 
                485                 490                 495     


Pro Gln Arg Tyr Leu Asp Ser Leu Thr Asn Tyr Arg Asn Arg Tyr Asp 
            500                 505                 510         


Ala Leu Thr Leu Asp Met Arg Arg Gln Ser Leu Leu Ala Leu Thr Pro 
        515                 520                 525             


Ala Gln Gln Gln Glu Phe Ala Asp Ala Gln Arg Asp Pro Gly Gly Gln 
    530                 535                 540                 


Ala Lys Arg Ala Cys Cys Leu Lys Leu Asn Leu Asn Pro Asp Glu Ile 
545                 550                 555                 560 


Arg Trp Asp Leu Val Ser Gly Ile Ser Thr Met Ile Ser Asp Leu Tyr 
                565                 570                 575     


Ile Glu Arg Gly Gly Asp Pro Arg Asp Val His Gln Gln Val Glu Thr 
            580                 585                 590         


Lys Pro Lys Gly Lys Arg Lys Ser Glu Ile Arg Ile Leu Lys Ile Arg 
        595                 600                 605             


Asp Gly Lys Trp Ala Tyr Asp Phe Arg Pro Lys Ile Ala Asp Glu Thr 
    610                 615                 620                 


Arg Lys Ala Gln Arg Glu Gln Leu Trp Lys Leu Gln Lys Ala Ser Ser 
625                 630                 635                 640 


Glu Phe Glu Arg Leu Ser Arg Tyr Lys Ile Asn Ile Ala Arg Ala Ile 
                645                 650                 655     


Ala Asn Trp Ala Leu Gln Trp Gly Arg Glu Leu Ser Gly Cys Asp Ile 
            660                 665                 670         


Val Ile Pro Val Leu Glu Asp Leu Asn Val Gly Ser Lys Phe Phe Asp 
        675                 680                 685             


Gly Lys Gly Lys Trp Leu Leu Gly Trp Asp Asn Arg Phe Thr Pro Lys 
    690                 695                 700                 


Lys Glu Asn Arg Trp Phe Ile Lys Val Leu His Lys Ala Val Ala Glu 
705                 710                 715                 720 


Leu Ala Pro His Arg Gly Val Pro Val Tyr Glu Val Met Pro His Arg 
                725                 730                 735     


Thr Ser Met Thr Cys Pro Ala Cys His Tyr Cys His Pro Thr Asn Arg 
            740                 745                 750         


Glu Gly Asp Arg Phe Glu Cys Gln Ser Cys His Val Val Lys Asn Thr 
        755                 760                 765             


Asp Arg Asp Val Ala Pro Tyr Asn Ile Leu Arg Val Ala Val Glu Gly 
    770                 775                 780                 


Lys Thr Leu Asp Arg Trp Gln Ala Glu Lys Lys Pro Gln Ala Glu Pro 
785                 790                 795                 800 


Asp Arg Pro Met Ile Leu Ile Asp Asn Gln Glu Ser 
                805                 810         


<210> 165
<211> 761
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 165
Met Ser Asn Lys Thr Thr Pro Pro Ser Pro Leu Ser Leu Leu Leu Arg 
1               5                   10                  15      


Ala His Phe Pro Gly Leu Lys Phe Glu Ser Gln Asp Tyr Lys Ile Ala 
            20                  25                  30          


Gly Lys Lys Leu Arg Asp Gly Gly Pro Glu Ala Val Ile Ser Tyr Leu 
        35                  40                  45              


Thr Gly Lys Gly Gln Ala Lys Leu Lys Asp Val Lys Pro Pro Ala Lys 
    50                  55                  60                  


Ala Phe Val Ile Ala Gln Ser Arg Pro Phe Ile Glu Trp Asp Leu Val 
65                  70                  75                  80  


Arg Val Ser Arg Gln Ile Gln Glu Lys Ile Phe Gly Ile Pro Ala Thr 
                85                  90                  95      


Lys Gly Arg Pro Lys Gln Asp Gly Leu Ser Glu Thr Ala Phe Asn Glu 
            100                 105                 110         


Ala Val Ala Ser Leu Glu Val Asp Gly Lys Ser Lys Leu Asn Glu Glu 
        115                 120                 125             


Thr Arg Ala Ala Phe Tyr Glu Val Leu Gly Leu Asp Ala Pro Ser Leu 
    130                 135                 140                 


His Ala Gln Ala Gln Asn Ala Leu Ile Lys Ser Ala Ile Ser Ile Arg 
145                 150                 155                 160 


Glu Gly Val Leu Lys Lys Val Glu Asn Arg Asn Glu Lys Asn Leu Ser 
                165                 170                 175     


Lys Thr Lys Arg Arg Lys Glu Ala Gly Glu Glu Ala Thr Phe Val Glu 
            180                 185                 190         


Glu Lys Ala His Asp Glu Arg Gly Tyr Leu Ile His Pro Pro Gly Val 
        195                 200                 205             


Asn Gln Thr Ile Pro Gly Tyr Gln Ala Val Val Ile Lys Ser Cys Pro 
    210                 215                 220                 


Ser Asp Phe Ile Gly Leu Pro Ser Gly Cys Leu Ala Lys Glu Ser Ala 
225                 230                 235                 240 


Glu Ala Leu Thr Asp Tyr Leu Pro His Asp Arg Met Thr Ile Pro Lys 
                245                 250                 255     


Gly Gln Pro Gly Tyr Val Pro Glu Trp Gln His Pro Leu Leu Asn Arg 
            260                 265                 270         


Arg Lys Asn Arg Arg Arg Arg Asp Trp Tyr Ser Ala Ser Leu Asn Lys 
        275                 280                 285             


Pro Lys Ala Thr Cys Ser Lys Arg Ser Gly Thr Pro Asn Arg Lys Asn 
    290                 295                 300                 


Ser Arg Thr Asp Gln Ile Gln Ser Gly Arg Phe Lys Gly Ala Ile Pro 
305                 310                 315                 320 


Val Leu Met Arg Phe Gln Asp Glu Trp Val Ile Ile Asp Ile Arg Gly 
                325                 330                 335     


Leu Leu Arg Asn Ala Arg Tyr Arg Lys Leu Leu Lys Glu Lys Ser Thr 
            340                 345                 350         


Ile Pro Asp Leu Leu Ser Leu Phe Thr Gly Asp Pro Ser Ile Asp Met 
        355                 360                 365             


Arg Gln Gly Val Cys Thr Phe Ile Tyr Lys Ala Gly Gln Ala Cys Ser 
    370                 375                 380                 


Ala Lys Met Val Lys Thr Lys Asn Ala Pro Glu Ile Leu Ser Glu Leu 
385                 390                 395                 400 


Thr Lys Ser Gly Pro Val Val Leu Val Ser Ile Asp Leu Gly Gln Thr 
                405                 410                 415     


Asn Pro Ile Ala Ala Lys Val Ser Arg Val Thr Gln Leu Ser Asp Gly 
            420                 425                 430         


Gln Leu Ser His Glu Thr Leu Leu Arg Glu Leu Leu Ser Asn Asp Ser 
        435                 440                 445             


Ser Asp Gly Lys Glu Ile Ala Arg Tyr Arg Val Ala Ser Asp Arg Leu 
    450                 455                 460                 


Arg Asp Lys Leu Ala Asn Leu Ala Val Glu Arg Leu Ser Pro Glu His 
465                 470                 475                 480 


Lys Ser Glu Ile Leu Arg Ala Lys Asn Asp Thr Pro Ala Leu Cys Lys 
                485                 490                 495     


Ala Arg Val Cys Ala Ala Leu Gly Leu Asn Pro Glu Met Ile Ala Trp 
            500                 505                 510         


Asp Lys Met Thr Pro Tyr Thr Glu Phe Leu Ala Thr Ala Tyr Leu Glu 
        515                 520                 525             


Lys Gly Gly Asp Arg Lys Val Ala Thr Leu Lys Pro Lys Asn Arg Pro 
    530                 535                 540                 


Glu Met Leu Arg Arg Asp Ile Lys Phe Lys Gly Thr Glu Gly Val Arg 
545                 550                 555                 560 


Ile Glu Val Ser Pro Glu Ala Ala Glu Ala Tyr Arg Glu Ala Gln Trp 
                565                 570                 575     


Asp Leu Gln Arg Thr Ser Pro Glu Tyr Leu Arg Leu Ser Thr Trp Lys 
            580                 585                 590         


Gln Glu Leu Thr Lys Arg Ile Leu Asn Gln Leu Arg His Lys Ala Ala 
        595                 600                 605             


Lys Ser Ser Gln Cys Glu Val Val Val Met Ala Phe Glu Asp Leu Asn 
    610                 615                 620                 


Ile Lys Met Met His Gly Asn Gly Lys Trp Ala Asp Gly Gly Trp Asp 
625                 630                 635                 640 


Ala Phe Phe Ile Lys Lys Arg Glu Asn Arg Trp Phe Met Gln Ala Phe 
                645                 650                 655     


His Lys Ser Leu Thr Glu Leu Gly Ala His Lys Gly Val Pro Thr Ile 
            660                 665                 670         


Glu Val Thr Pro His Arg Thr Ser Ile Thr Cys Thr Lys Cys Gly His 
        675                 680                 685             


Cys Asp Lys Ala Asn Arg Asp Gly Glu Arg Phe Ala Cys Gln Lys Cys 
    690                 695                 700                 


Gly Phe Val Ala His Ala Asp Leu Glu Ile Ala Thr Asp Asn Ile Glu 
705                 710                 715                 720 


Arg Val Ala Leu Thr Gly Lys Pro Met Pro Lys Pro Glu Ser Glu Arg 
                725                 730                 735     


Ser Gly Asp Ala Lys Lys Ser Val Gly Ala Arg Lys Ala Ala Phe Lys 
            740                 745                 750         


Pro Glu Glu Asp Ala Glu Ala Ala Glu 
        755                 760     


<210> 166
<211> 717
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 166
Met Ile Lys Pro Thr Val Ser Gln Phe Leu Thr Pro Gly Phe Lys Leu 
1               5                   10                  15      


Ile Arg Asn His Ser Arg Thr Ala Gly Leu Lys Leu Lys Asn Glu Gly 
            20                  25                  30          


Glu Glu Ala Cys Lys Lys Phe Val Arg Glu Asn Glu Ile Pro Lys Asp 
        35                  40                  45              


Glu Cys Pro Asn Phe Gln Gly Gly Pro Ala Ile Ala Asn Ile Ile Ala 
    50                  55                  60                  


Lys Ser Arg Glu Phe Thr Glu Trp Glu Ile Tyr Gln Ser Ser Leu Ala 
65                  70                  75                  80  


Ile Gln Glu Val Ile Phe Thr Leu Pro Lys Asp Lys Leu Pro Glu Pro 
                85                  90                  95      


Ile Leu Lys Glu Glu Trp Arg Ala Gln Trp Leu Ser Glu His Gly Leu 
            100                 105                 110         


Asp Thr Val Pro Tyr Lys Glu Ala Ala Gly Leu Asn Leu Ile Ile Lys 
        115                 120                 125             


Asn Ala Val Asn Thr Tyr Lys Gly Val Gln Val Lys Val Asp Asn Lys 
    130                 135                 140                 


Asn Lys Asn Asn Leu Ala Lys Ile Asn Arg Lys Asn Glu Ile Ala Lys 
145                 150                 155                 160 


Leu Asn Gly Glu Gln Glu Ile Ser Phe Glu Glu Ile Lys Ala Phe Asp 
                165                 170                 175     


Asp Lys Gly Tyr Leu Leu Gln Lys Pro Ser Pro Asn Lys Ser Ile Tyr 
            180                 185                 190         


Cys Tyr Gln Ser Val Ser Pro Lys Pro Phe Ile Thr Ser Lys Tyr His 
        195                 200                 205             


Asn Val Asn Leu Pro Glu Glu Tyr Ile Gly Tyr Tyr Arg Lys Ser Asn 
    210                 215                 220                 


Glu Pro Ile Val Ser Pro Tyr Gln Phe Asp Arg Leu Arg Ile Pro Ile 
225                 230                 235                 240 


Gly Glu Pro Gly Tyr Val Pro Lys Trp Gln Tyr Thr Phe Leu Ser Lys 
                245                 250                 255     


Lys Glu Asn Lys Arg Arg Lys Leu Ser Lys Arg Ile Lys Asn Val Ser 
            260                 265                 270         


Pro Ile Leu Gly Ile Ile Cys Ile Lys Lys Asp Trp Cys Val Phe Asp 
        275                 280                 285             


Met Arg Gly Leu Leu Arg Thr Asn His Trp Lys Lys Tyr His Lys Pro 
    290                 295                 300                 


Thr Asp Ser Ile Asn Asp Leu Phe Asp Tyr Phe Thr Gly Asp Pro Val 
305                 310                 315                 320 


Ile Asp Thr Lys Ala Asn Val Val Arg Phe Arg Tyr Lys Met Glu Asn 
                325                 330                 335     


Gly Ile Val Asn Tyr Lys Pro Val Arg Glu Lys Lys Gly Lys Glu Leu 
            340                 345                 350         


Leu Glu Asn Ile Cys Asp Gln Asn Gly Ser Cys Lys Leu Ala Thr Val 
        355                 360                 365             


Asp Val Gly Gln Asn Asn Pro Val Ala Ile Gly Leu Phe Glu Leu Lys 
    370                 375                 380                 


Lys Val Asn Gly Glu Leu Thr Lys Thr Leu Ile Ser Arg His Pro Thr 
385                 390                 395                 400 


Pro Ile Asp Phe Cys Asn Lys Ile Thr Ala Tyr Arg Glu Arg Tyr Asp 
                405                 410                 415     


Lys Leu Glu Ser Ser Ile Lys Leu Asp Ala Ile Lys Gln Leu Thr Ser 
            420                 425                 430         


Glu Gln Lys Ile Glu Val Asp Asn Tyr Asn Asn Asn Phe Thr Pro Gln 
        435                 440                 445             


Asn Thr Lys Gln Ile Val Cys Ser Lys Leu Asn Ile Asn Pro Asn Asp 
    450                 455                 460                 


Leu Pro Trp Asp Lys Met Ile Ser Gly Thr His Phe Ile Ser Glu Lys 
465                 470                 475                 480 


Ala Gln Val Ser Asn Lys Ser Glu Ile Tyr Phe Thr Ser Thr Asp Lys 
                485                 490                 495     


Gly Lys Thr Lys Asp Val Met Lys Ser Asp Tyr Lys Trp Phe Gln Asp 
            500                 505                 510         


Tyr Lys Pro Lys Leu Ser Lys Glu Val Arg Asp Ala Leu Ser Asp Ile 
        515                 520                 525             


Glu Trp Arg Leu Arg Arg Glu Ser Leu Glu Phe Asn Lys Leu Ser Lys 
    530                 535                 540                 


Ser Arg Glu Gln Asp Ala Arg Gln Leu Ala Asn Trp Ile Ser Ser Met 
545                 550                 555                 560 


Cys Asp Val Ile Gly Ile Glu Asn Leu Val Lys Lys Asn Asn Phe Phe 
                565                 570                 575     


Gly Gly Ser Gly Lys Arg Glu Pro Gly Trp Asp Asn Phe Tyr Lys Pro 
            580                 585                 590         


Lys Lys Glu Asn Arg Trp Trp Ile Asn Ala Ile His Lys Ala Leu Thr 
        595                 600                 605             


Glu Leu Ser Gln Asn Lys Gly Lys Arg Val Ile Leu Leu Pro Ala Met 
    610                 615                 620                 


Arg Thr Ser Ile Thr Cys Pro Lys Cys Lys Tyr Cys Asp Ser Lys Asn 
625                 630                 635                 640 


Arg Asn Gly Glu Lys Phe Asn Cys Leu Lys Cys Gly Ile Glu Leu Asn 
                645                 650                 655     


Ala Asp Ile Asp Val Ala Thr Glu Asn Leu Ala Thr Val Ala Ile Thr 
            660                 665                 670         


Ala Gln Ser Met Pro Lys Pro Thr Cys Glu Arg Ser Gly Asp Ala Lys 
        675                 680                 685             


Lys Pro Val Arg Ala Arg Lys Ala Lys Ala Pro Glu Phe His Asp Lys 
    690                 695                 700                 


Leu Ala Pro Ser Tyr Thr Val Val Leu Arg Glu Ala Val 
705                 710                 715         


<210> 167
<211> 781
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 167
Met Arg Gln Pro Ala Glu Lys Thr Ala Phe Gln Val Phe Arg Gln Glu 
1               5                   10                  15      


Val Ile Gly Thr Gln Lys Leu Ser Gly Gly Asp Ala Lys Thr Ala Gly 
            20                  25                  30          


Arg Leu Tyr Lys Gln Gly Lys Met Glu Ala Ala Arg Glu Trp Leu Leu 
        35                  40                  45              


Lys Gly Ala Arg Asp Asp Val Pro Pro Asn Phe Gln Pro Pro Ala Lys 
    50                  55                  60                  


Cys Leu Val Val Ala Val Ser His Pro Phe Glu Glu Trp Asp Ile Ser 
65                  70                  75                  80  


Lys Thr Asn His Asp Val Gln Ala Tyr Ile Tyr Ala Gln Pro Leu Gln 
                85                  90                  95      


Ala Glu Gly His Leu Asn Gly Leu Ser Glu Lys Trp Glu Asp Thr Ser 
            100                 105                 110         


Ala Asp Gln His Lys Leu Trp Phe Glu Lys Thr Gly Val Pro Asp Arg 
        115                 120                 125             


Gly Leu Pro Val Gln Ala Ile Asn Lys Ile Ala Lys Ala Ala Val Asn 
    130                 135                 140                 


Arg Ala Phe Gly Val Val Arg Lys Val Glu Asn Arg Asn Glu Lys Arg 
145                 150                 155                 160 


Arg Ser Arg Asp Asn Arg Ile Ala Glu His Asn Arg Glu Asn Gly Leu 
                165                 170                 175     


Thr Glu Val Val Arg Glu Ala Pro Glu Val Ala Thr Asn Ala Asp Gly 
            180                 185                 190         


Phe Leu Leu His Pro Pro Gly Ile Asp Pro Ser Ile Leu Ser Tyr Ala 
        195                 200                 205             


Ser Val Ser Pro Val Pro Tyr Asn Ser Ser Lys His Ser Phe Val Arg 
    210                 215                 220                 


Leu Pro Glu Glu Tyr Gln Ala Tyr Asn Val Glu Pro Asp Ala Pro Ile 
225                 230                 235                 240 


Pro Gln Phe Val Val Glu Asp Arg Phe Ala Ile Pro Pro Gly Gln Pro 
                245                 250                 255     


Gly Tyr Val Pro Glu Trp Gln Arg Leu Lys Cys Ser Thr Asn Lys His 
            260                 265                 270         


Arg Arg Met Arg Gln Trp Ser Asn Gln Asp Tyr Lys Pro Lys Ala Gly 
        275                 280                 285             


Arg Arg Ala Lys Pro Leu Glu Phe Gln Ala His Leu Thr Arg Glu Arg 
    290                 295                 300                 


Ala Lys Gly Ala Leu Leu Val Val Met Arg Ile Lys Glu Asp Trp Val 
305                 310                 315                 320 


Val Phe Asp Val Arg Gly Leu Leu Arg Asn Val Glu Trp Arg Lys Val 
                325                 330                 335     


Leu Ser Glu Glu Ala Arg Glu Lys Leu Thr Leu Lys Gly Leu Leu Asp 
            340                 345                 350         


Leu Phe Thr Gly Asp Pro Val Ile Asp Thr Lys Arg Gly Ile Val Thr 
        355                 360                 365             


Phe Leu Tyr Lys Ala Glu Ile Thr Lys Ile Leu Ser Lys Arg Thr Val 
    370                 375                 380                 


Lys Thr Lys Asn Ala Arg Asp Leu Leu Leu Arg Leu Thr Glu Pro Gly 
385                 390                 395                 400 


Glu Asp Gly Leu Arg Arg Glu Val Gly Leu Val Ala Val Asp Leu Gly 
                405                 410                 415     


Gln Thr His Pro Ile Ala Ala Ala Ile Tyr Arg Ile Gly Arg Thr Ser 
            420                 425                 430         


Ala Gly Ala Leu Glu Ser Thr Val Leu His Arg Gln Gly Leu Arg Glu 
        435                 440                 445             


Asp Gln Lys Glu Lys Leu Lys Glu Tyr Arg Lys Arg His Thr Ala Leu 
    450                 455                 460                 


Asp Ser Arg Leu Arg Lys Glu Ala Phe Glu Thr Leu Ser Val Glu Gln 
465                 470                 475                 480 


Gln Lys Glu Ile Val Thr Val Ser Gly Ser Gly Ala Gln Ile Thr Lys 
                485                 490                 495     


Asp Lys Val Cys Asn Tyr Leu Gly Val Asp Pro Ser Thr Leu Pro Trp 
            500                 505                 510         


Glu Lys Met Gly Ser Tyr Thr His Phe Ile Ser Asp Asp Phe Leu Arg 
        515                 520                 525             


Arg Gly Gly Asp Pro Asn Ile Val His Phe Asp Arg Gln Pro Lys Lys 
    530                 535                 540                 


Gly Lys Val Ser Lys Lys Ser Gln Arg Ile Lys Arg Ser Asp Ser Gln 
545                 550                 555                 560 


Trp Val Gly Arg Met Arg Pro Arg Leu Ser Gln Glu Thr Ala Lys Ala 
                565                 570                 575     


Arg Met Glu Ala Asp Trp Ala Ala Gln Asn Glu Asn Glu Glu Tyr Lys 
            580                 585                 590         


Arg Leu Ala Arg Ser Lys Gln Glu Leu Ala Arg Trp Cys Val Asn Thr 
        595                 600                 605             


Leu Leu Gln Asn Thr Arg Cys Ile Thr Gln Cys Asp Glu Ile Val Val 
    610                 615                 620                 


Val Ile Glu Asp Leu Asn Val Lys Ser Leu His Gly Lys Gly Ala Arg 
625                 630                 635                 640 


Glu Pro Gly Trp Asp Asn Phe Phe Thr Pro Lys Thr Glu Asn Arg Trp 
                645                 650                 655     


Phe Ile Gln Ile Leu His Lys Thr Phe Ser Glu Leu Pro Lys His Arg 
            660                 665                 670         


Gly Glu His Val Ile Glu Gly Cys Pro Leu Arg Thr Ser Ile Thr Cys 
        675                 680                 685             


Pro Ala Cys Ser Tyr Cys Asp Lys Asn Ser Arg Asn Gly Glu Lys Phe 
    690                 695                 700                 


Val Cys Val Ala Cys Gly Ala Thr Phe His Ala Asp Phe Glu Val Ala 
705                 710                 715                 720 


Thr Tyr Asn Leu Val Arg Leu Ala Thr Thr Gly Met Pro Met Pro Lys 
                725                 730                 735     


Ser Leu Glu Arg Gln Gly Gly Gly Glu Lys Ala Gly Gly Ala Arg Lys 
            740                 745                 750         


Ala Arg Lys Lys Ala Lys Gln Val Glu Lys Ile Val Val Gln Ala Asn 
        755                 760                 765             


Ala Asn Val Thr Met Asn Gly Ala Ser Leu His Ser Pro 
    770                 775                 780     


<210> 168
<211> 793
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 168
Met Ser Ser Leu Pro Thr Pro Leu Glu Leu Leu Lys Gln Lys His Ala 
1               5                   10                  15      


Asp Leu Phe Lys Gly Leu Gln Phe Ser Ser Lys Asp Asn Lys Met Ala 
            20                  25                  30          


Gly Lys Val Leu Lys Lys Asp Gly Glu Glu Ala Ala Leu Ala Phe Leu 
        35                  40                  45              


Ser Glu Arg Gly Val Ser Arg Gly Glu Leu Pro Asn Phe Arg Pro Pro 
    50                  55                  60                  


Ala Lys Thr Leu Val Val Ala Gln Ser Arg Pro Phe Glu Glu Phe Pro 
65                  70                  75                  80  


Ile Tyr Arg Val Ser Glu Ala Ile Gln Leu Tyr Val Tyr Ser Leu Ser 
                85                  90                  95      


Val Lys Glu Leu Glu Thr Val Pro Ser Gly Ser Ser Thr Lys Lys Glu 
            100                 105                 110         


His Gln Arg Phe Phe Gln Asp Ser Ser Val Pro Asp Phe Gly Tyr Thr 
        115                 120                 125             


Ser Val Gln Gly Leu Asn Lys Ile Phe Gly Leu Ala Arg Gly Ile Tyr 
    130                 135                 140                 


Leu Gly Val Ile Thr Arg Gly Glu Asn Gln Leu Gln Lys Ala Lys Ser 
145                 150                 155                 160 


Lys His Glu Ala Leu Asn Lys Lys Arg Arg Ala Ser Gly Glu Ala Glu 
                165                 170                 175     


Thr Glu Phe Asp Pro Thr Pro Tyr Glu Tyr Met Thr Pro Glu Arg Lys 
            180                 185                 190         


Leu Ala Lys Pro Pro Gly Val Asn His Ser Ile Met Cys Tyr Val Asp 
        195                 200                 205             


Ile Ser Val Asp Glu Phe Asp Phe Arg Asn Pro Asp Gly Ile Val Leu 
    210                 215                 220                 


Pro Ser Glu Tyr Ala Gly Tyr Cys Arg Glu Ile Asn Thr Ala Ile Glu 
225                 230                 235                 240 


Lys Gly Thr Val Asp Arg Leu Gly His Leu Lys Gly Gly Pro Gly Tyr 
                245                 250                 255     


Ile Pro Gly His Gln Arg Lys Glu Ser Thr Thr Glu Gly Pro Lys Ile 
            260                 265                 270         


Asn Phe Arg Lys Gly Arg Ile Arg Arg Ser Tyr Thr Ala Leu Tyr Ala 
        275                 280                 285             


Lys Arg Asp Ser Arg Arg Val Arg Gln Gly Lys Leu Ala Leu Pro Ser 
    290                 295                 300                 


Tyr Arg His His Met Met Arg Leu Asn Ser Asn Ala Glu Ser Ala Ile 
305                 310                 315                 320 


Leu Ala Val Ile Phe Phe Gly Lys Asp Trp Val Val Phe Asp Leu Arg 
                325                 330                 335     


Gly Leu Leu Arg Asn Val Arg Trp Arg Asn Leu Phe Val Asp Gly Ser 
            340                 345                 350         


Thr Pro Ser Thr Leu Leu Gly Met Phe Gly Asp Pro Val Ile Asp Pro 
        355                 360                 365             


Lys Arg Gly Val Val Ala Phe Cys Tyr Lys Glu Gln Ile Val Pro Val 
    370                 375                 380                 


Val Ser Lys Ser Ile Thr Lys Met Val Lys Ala Pro Glu Leu Leu Asn 
385                 390                 395                 400 


Lys Leu Tyr Leu Lys Ser Glu Asp Pro Leu Val Leu Val Ala Ile Asp 
                405                 410                 415     


Leu Gly Gln Thr Asn Pro Val Gly Val Gly Val Tyr Arg Val Met Asn 
            420                 425                 430         


Ala Ser Leu Asp Tyr Glu Val Val Thr Arg Phe Ala Leu Glu Ser Glu 
        435                 440                 445             


Leu Leu Arg Glu Ile Glu Ser Tyr Arg Gln Arg Thr Asn Ala Phe Glu 
    450                 455                 460                 


Ala Gln Ile Arg Ala Glu Thr Phe Asp Ala Met Thr Ser Glu Glu Gln 
465                 470                 475                 480 


Glu Glu Ile Thr Arg Val Arg Ala Phe Ser Ala Ser Lys Ala Lys Glu 
                485                 490                 495     


Asn Val Cys His Arg Phe Gly Met Pro Val Asp Ala Val Asp Trp Ala 
            500                 505                 510         


Thr Met Gly Ser Asn Thr Ile His Ile Ala Lys Trp Val Met Arg His 
        515                 520                 525             


Gly Asp Pro Ser Leu Val Glu Val Leu Glu Tyr Arg Lys Asp Asn Glu 
    530                 535                 540                 


Ile Lys Leu Asp Lys Asn Gly Val Pro Lys Lys Val Lys Leu Thr Asp 
545                 550                 555                 560 


Lys Arg Ile Ala Asn Leu Thr Ser Ile Arg Leu Arg Phe Ser Gln Glu 
                565                 570                 575     


Thr Ser Lys His Tyr Asn Asp Thr Met Trp Glu Leu Arg Arg Lys His 
            580                 585                 590         


Pro Val Tyr Gln Lys Leu Ser Lys Ser Lys Ala Asp Phe Ser Arg Arg 
        595                 600                 605             


Val Val Asn Ser Ile Ile Arg Arg Val Asn His Leu Val Pro Arg Ala 
    610                 615                 620                 


Arg Ile Val Phe Ile Ile Glu Asp Leu Lys Asn Leu Gly Lys Val Phe 
625                 630                 635                 640 


His Gly Ser Gly Lys Arg Glu Leu Gly Trp Asp Ser Tyr Phe Glu Pro 
                645                 650                 655     


Lys Ser Glu Asn Arg Trp Phe Ile Gln Val Leu His Lys Ala Phe Ser 
            660                 665                 670         


Glu Thr Gly Lys His Lys Gly Tyr Tyr Ile Ile Glu Cys Trp Pro Asn 
        675                 680                 685             


Trp Thr Ser Cys Thr Cys Pro Lys Cys Ser Cys Cys Asp Ser Glu Asn 
    690                 695                 700                 


Arg His Gly Glu Val Phe Arg Cys Leu Ala Cys Gly Tyr Thr Cys Asn 
705                 710                 715                 720 


Thr Asp Phe Gly Thr Ala Pro Asp Asn Leu Val Lys Ile Ala Thr Thr 
                725                 730                 735     


Gly Lys Gly Leu Pro Gly Pro Lys Lys Arg Cys Lys Gly Ser Ser Lys 
            740                 745                 750         


Gly Lys Asn Pro Lys Ile Ala Arg Ser Ser Glu Thr Gly Val Ser Val 
        755                 760                 765             


Thr Glu Ser Gly Ala Pro Lys Val Lys Lys Ser Ser Pro Thr Gln Thr 
    770                 775                 780                 


Ser Gln Ser Ser Ser Gln Ser Ala Pro 
785                 790             


<210> 169
<211> 717
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 169
Met Ile Lys Pro Thr Val Ser Gln Phe Leu Thr Pro Gly Phe Lys Leu 
1               5                   10                  15      


Ile Arg Asn His Ser Arg Thr Ala Gly Leu Lys Leu Lys Asn Glu Gly 
            20                  25                  30          


Glu Glu Ala Cys Lys Lys Phe Val Arg Glu Asn Glu Ile Pro Lys Asp 
        35                  40                  45              


Glu Cys Pro Asn Phe Gln Gly Gly Pro Ala Ile Ala Asn Ile Ile Ala 
    50                  55                  60                  


Lys Ser Arg Glu Phe Thr Glu Trp Glu Ile Tyr Gln Ser Ser Leu Ala 
65                  70                  75                  80  


Ile Gln Glu Val Ile Phe Thr Leu Pro Lys Asp Lys Leu Pro Glu Pro 
                85                  90                  95      


Ile Leu Lys Glu Glu Trp Arg Ala Gln Trp Leu Ser Glu His Gly Leu 
            100                 105                 110         


Asp Thr Val Pro Tyr Lys Glu Ala Ala Gly Leu Asn Leu Ile Ile Lys 
        115                 120                 125             


Asn Ala Val Asn Thr Tyr Lys Gly Val Gln Val Lys Val Asp Asn Lys 
    130                 135                 140                 


Asn Lys Asn Asn Leu Ala Lys Ile Asn Arg Lys Asn Glu Ile Ala Lys 
145                 150                 155                 160 


Leu Asn Gly Glu Gln Glu Ile Ser Phe Glu Glu Ile Lys Ala Phe Asp 
                165                 170                 175     


Asp Lys Gly Tyr Leu Leu Gln Lys Pro Ser Pro Asn Lys Ser Ile Tyr 
            180                 185                 190         


Cys Tyr Gln Ser Val Ser Pro Lys Pro Phe Ile Thr Ser Lys Tyr His 
        195                 200                 205             


Asn Val Asn Leu Pro Glu Glu Tyr Ile Gly Tyr Tyr Arg Lys Ser Asn 
    210                 215                 220                 


Glu Pro Ile Val Ser Pro Tyr Gln Phe Asp Arg Leu Arg Ile Pro Ile 
225                 230                 235                 240 


Gly Glu Pro Gly Tyr Val Pro Lys Trp Gln Tyr Thr Phe Leu Ser Lys 
                245                 250                 255     


Lys Glu Asn Lys Arg Arg Lys Leu Ser Lys Arg Ile Lys Asn Val Ser 
            260                 265                 270         


Pro Ile Leu Gly Ile Ile Cys Ile Lys Lys Asp Trp Cys Val Phe Asp 
        275                 280                 285             


Met Arg Gly Leu Leu Arg Thr Asn His Trp Lys Lys Tyr His Lys Pro 
    290                 295                 300                 


Thr Asp Ser Ile Asn Asp Leu Phe Asp Tyr Phe Thr Gly Asp Pro Val 
305                 310                 315                 320 


Ile Asp Thr Lys Ala Asn Val Val Arg Phe Arg Tyr Lys Met Glu Asn 
                325                 330                 335     


Gly Ile Val Asn Tyr Lys Pro Val Arg Glu Lys Lys Gly Lys Glu Leu 
            340                 345                 350         


Leu Glu Asn Ile Cys Asp Gln Asn Gly Ser Cys Lys Leu Ala Thr Val 
        355                 360                 365             


Asp Val Gly Gln Asn Asn Pro Val Ala Ile Gly Leu Phe Glu Leu Lys 
    370                 375                 380                 


Lys Val Asn Gly Glu Leu Thr Lys Thr Leu Ile Ser Arg His Pro Thr 
385                 390                 395                 400 


Pro Ile Asp Phe Cys Asn Lys Ile Thr Ala Tyr Arg Glu Arg Tyr Asp 
                405                 410                 415     


Lys Leu Glu Ser Ser Ile Lys Leu Asp Ala Ile Lys Gln Leu Thr Ser 
            420                 425                 430         


Glu Gln Lys Ile Glu Val Asp Asn Tyr Asn Asn Asn Phe Thr Pro Gln 
        435                 440                 445             


Asn Thr Lys Gln Ile Val Cys Ser Lys Leu Asn Ile Asn Pro Asn Asp 
    450                 455                 460                 


Leu Pro Trp Asp Lys Met Ile Ser Gly Thr His Phe Ile Ser Glu Lys 
465                 470                 475                 480 


Ala Gln Val Ser Asn Lys Ser Glu Ile Tyr Phe Thr Ser Thr Asp Lys 
                485                 490                 495     


Gly Lys Thr Lys Asp Val Met Lys Ser Asp Tyr Lys Trp Phe Gln Asp 
            500                 505                 510         


Tyr Lys Pro Lys Leu Ser Lys Glu Val Arg Asp Ala Leu Ser Asp Ile 
        515                 520                 525             


Glu Trp Arg Leu Arg Arg Glu Ser Leu Glu Phe Asn Lys Leu Ser Lys 
    530                 535                 540                 


Ser Arg Glu Gln Asp Ala Arg Gln Leu Ala Asn Trp Ile Ser Ser Met 
545                 550                 555                 560 


Cys Asp Val Ile Gly Ile Glu Asn Leu Val Lys Lys Asn Asn Phe Phe 
                565                 570                 575     


Gly Gly Ser Gly Lys Arg Glu Pro Gly Trp Asp Asn Phe Tyr Lys Pro 
            580                 585                 590         


Lys Lys Glu Asn Arg Trp Trp Ile Asn Ala Ile His Lys Ala Leu Thr 
        595                 600                 605             


Glu Leu Ser Gln Asn Lys Gly Lys Arg Val Ile Leu Leu Pro Ala Met 
    610                 615                 620                 


Arg Thr Ser Ile Thr Cys Pro Lys Cys Lys Tyr Cys Asp Ser Lys Asn 
625                 630                 635                 640 


Arg Asn Gly Glu Lys Phe Asn Cys Leu Lys Cys Gly Ile Glu Leu Asn 
                645                 650                 655     


Ala Asp Ile Asp Val Ala Thr Glu Asn Leu Ala Thr Val Ala Ile Thr 
            660                 665                 670         


Ala Gln Ser Met Pro Lys Pro Thr Cys Glu Arg Ser Gly Asp Ala Lys 
        675                 680                 685             


Lys Pro Val Arg Ala Arg Lys Ala Lys Ala Pro Glu Phe His Asp Lys 
    690                 695                 700                 


Leu Ala Pro Ser Tyr Thr Val Val Leu Arg Glu Ala Val 
705                 710                 715         


<210> 170
<211> 761
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 170
Met Ser Asn Lys Thr Thr Pro Pro Ser Pro Leu Ser Leu Leu Leu Arg 
1               5                   10                  15      


Ala His Phe Pro Gly Leu Lys Phe Glu Ser Gln Asp Tyr Lys Ile Ala 
            20                  25                  30          


Gly Lys Lys Leu Arg Asp Gly Gly Pro Glu Ala Val Ile Ser Tyr Leu 
        35                  40                  45              


Thr Gly Lys Gly Gln Ala Lys Leu Lys Asp Val Lys Pro Pro Ala Lys 
    50                  55                  60                  


Ala Phe Val Ile Ala Gln Ser Arg Pro Phe Ile Glu Trp Asp Leu Val 
65                  70                  75                  80  


Arg Val Ser Arg Gln Ile Gln Glu Lys Ile Phe Gly Ile Pro Ala Thr 
                85                  90                  95      


Lys Gly Arg Pro Lys Gln Asp Gly Leu Ser Glu Thr Ala Phe Asn Glu 
            100                 105                 110         


Ala Val Ala Ser Leu Glu Val Asp Gly Lys Ser Lys Leu Asn Glu Glu 
        115                 120                 125             


Thr Arg Ala Ala Phe Tyr Glu Val Leu Gly Leu Asp Ala Pro Ser Leu 
    130                 135                 140                 


His Ala Gln Ala Gln Asn Ala Leu Ile Lys Ser Ala Ile Ser Ile Arg 
145                 150                 155                 160 


Glu Gly Val Leu Lys Lys Val Glu Asn Arg Asn Glu Lys Asn Leu Ser 
                165                 170                 175     


Lys Thr Lys Arg Arg Lys Glu Ala Gly Glu Glu Ala Thr Phe Val Glu 
            180                 185                 190         


Glu Lys Ala His Asp Glu Arg Gly Tyr Leu Ile His Pro Pro Gly Val 
        195                 200                 205             


Asn Gln Thr Ile Pro Gly Tyr Gln Ala Val Val Ile Lys Ser Cys Pro 
    210                 215                 220                 


Ser Asp Phe Ile Gly Leu Pro Ser Gly Cys Leu Ala Lys Glu Ser Ala 
225                 230                 235                 240 


Glu Ala Leu Thr Asp Tyr Leu Pro His Asp Arg Met Thr Ile Pro Lys 
                245                 250                 255     


Gly Gln Pro Gly Tyr Val Pro Glu Trp Gln His Pro Leu Leu Asn Arg 
            260                 265                 270         


Arg Lys Asn Arg Arg Arg Arg Asp Trp Tyr Ser Ala Ser Leu Asn Lys 
        275                 280                 285             


Pro Lys Ala Thr Cys Ser Lys Arg Ser Gly Thr Pro Asn Arg Lys Asn 
    290                 295                 300                 


Ser Arg Thr Asp Gln Ile Gln Ser Gly Arg Phe Lys Gly Ala Ile Pro 
305                 310                 315                 320 


Val Leu Met Arg Phe Gln Asp Glu Trp Val Ile Ile Asp Ile Arg Gly 
                325                 330                 335     


Leu Leu Arg Asn Ala Arg Tyr Arg Lys Leu Leu Lys Glu Lys Ser Thr 
            340                 345                 350         


Ile Pro Asp Leu Leu Ser Leu Phe Thr Gly Asp Pro Ser Ile Asp Met 
        355                 360                 365             


Arg Gln Gly Val Cys Thr Phe Ile Tyr Lys Ala Gly Gln Ala Cys Ser 
    370                 375                 380                 


Ala Lys Met Val Lys Thr Lys Asn Ala Pro Glu Ile Leu Ser Glu Leu 
385                 390                 395                 400 


Thr Lys Ser Gly Pro Val Val Leu Val Ser Ile Asp Leu Gly Gln Thr 
                405                 410                 415     


Asn Pro Ile Ala Ala Lys Val Ser Arg Val Thr Gln Leu Ser Asp Gly 
            420                 425                 430         


Gln Leu Ser His Glu Thr Leu Leu Arg Glu Leu Leu Ser Asn Asp Ser 
        435                 440                 445             


Ser Asp Gly Lys Glu Ile Ala Arg Tyr Arg Val Ala Ser Asp Arg Leu 
    450                 455                 460                 


Arg Asp Lys Leu Ala Asn Leu Ala Val Glu Arg Leu Ser Pro Glu His 
465                 470                 475                 480 


Lys Ser Glu Ile Leu Arg Ala Lys Asn Asp Thr Pro Ala Leu Cys Lys 
                485                 490                 495     


Ala Arg Val Cys Ala Ala Leu Gly Leu Asn Pro Glu Met Ile Ala Trp 
            500                 505                 510         


Asp Lys Met Thr Pro Tyr Thr Glu Phe Leu Ala Thr Ala Tyr Leu Glu 
        515                 520                 525             


Lys Gly Gly Asp Arg Lys Val Ala Thr Leu Lys Pro Lys Asn Arg Pro 
    530                 535                 540                 


Glu Met Leu Arg Arg Asp Ile Lys Phe Lys Gly Thr Glu Gly Val Arg 
545                 550                 555                 560 


Ile Glu Val Ser Pro Glu Ala Ala Glu Ala Tyr Arg Glu Ala Gln Trp 
                565                 570                 575     


Asp Leu Gln Arg Thr Ser Pro Glu Tyr Leu Arg Leu Ser Thr Trp Lys 
            580                 585                 590         


Gln Glu Leu Thr Lys Arg Ile Leu Asn Gln Leu Arg His Lys Ala Ala 
        595                 600                 605             


Lys Ser Ser Gln Cys Glu Val Val Val Met Ala Phe Glu Asp Leu Asn 
    610                 615                 620                 


Ile Lys Met Met His Gly Asn Gly Lys Trp Ala Asp Gly Gly Trp Asp 
625                 630                 635                 640 


Ala Phe Phe Ile Lys Lys Arg Glu Asn Arg Trp Phe Met Gln Ala Phe 
                645                 650                 655     


His Lys Ser Leu Thr Glu Leu Gly Ala His Lys Gly Val Pro Thr Ile 
            660                 665                 670         


Glu Val Thr Pro His Arg Thr Ser Ile Thr Cys Thr Lys Cys Gly His 
        675                 680                 685             


Cys Asp Lys Ala Asn Arg Asp Gly Glu Arg Phe Ala Cys Gln Lys Cys 
    690                 695                 700                 


Gly Phe Val Ala His Ala Asp Leu Glu Ile Ala Thr Asp Asn Ile Glu 
705                 710                 715                 720 


Arg Val Ala Leu Thr Gly Lys Pro Met Pro Lys Pro Glu Ser Glu Arg 
                725                 730                 735     


Ser Gly Asp Ala Lys Lys Ser Val Gly Ala Arg Lys Ala Ala Phe Lys 
            740                 745                 750         


Pro Glu Glu Asp Ala Glu Ala Ala Glu 
        755                 760     


<210> 171
<211> 765
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 171
Met Tyr Ser Leu Glu Met Ala Asp Leu Lys Ser Glu Pro Ser Leu Leu 
1               5                   10                  15      


Ala Lys Leu Leu Arg Asp Arg Phe Pro Gly Lys Tyr Trp Leu Pro Lys 
            20                  25                  30          


Tyr Trp Lys Leu Ala Glu Lys Lys Arg Leu Thr Gly Gly Glu Glu Ala 
        35                  40                  45              


Ala Cys Glu Tyr Met Ala Asp Lys Gln Leu Asp Ser Pro Pro Pro Asn 
    50                  55                  60                  


Phe Arg Pro Pro Ala Arg Cys Val Ile Leu Ala Lys Ser Arg Pro Phe 
65                  70                  75                  80  


Glu Asp Trp Pro Val His Arg Val Ala Ser Lys Ala Gln Ser Phe Val 
                85                  90                  95      


Ile Gly Leu Ser Glu Gln Gly Phe Ala Ala Leu Arg Ala Ala Pro Pro 
            100                 105                 110         


Ser Thr Ala Asp Ala Arg Arg Asp Trp Leu Arg Ser His Gly Ala Ser 
        115                 120                 125             


Glu Asp Asp Leu Met Ala Leu Glu Ala Gln Leu Leu Glu Thr Ile Met 
    130                 135                 140                 


Gly Asn Ala Ile Ser Leu His Gly Gly Val Leu Lys Lys Ile Asp Asn 
145                 150                 155                 160 


Ala Asn Val Lys Ala Ala Lys Arg Leu Ser Gly Arg Asn Glu Ala Arg 
                165                 170                 175     


Leu Asn Lys Gly Leu Gln Glu Leu Pro Pro Glu Gln Glu Gly Ser Ala 
            180                 185                 190         


Tyr Gly Ala Asp Gly Leu Leu Val Asn Pro Pro Gly Leu Asn Leu Asn 
        195                 200                 205             


Ile Tyr Cys Arg Lys Ser Cys Cys Pro Lys Pro Val Lys Asn Thr Ala 
    210                 215                 220                 


Arg Phe Val Gly His Tyr Pro Gly Tyr Leu Arg Asp Ser Asp Ser Ile 
225                 230                 235                 240 


Leu Ile Ser Gly Thr Met Asp Arg Leu Thr Ile Ile Glu Gly Met Pro 
                245                 250                 255     


Gly His Ile Pro Ala Trp Gln Arg Glu Gln Gly Leu Val Lys Pro Gly 
            260                 265                 270         


Gly Arg Arg Arg Arg Leu Ser Gly Ser Glu Ser Asn Met Arg Gln Lys 
        275                 280                 285             


Val Asp Pro Ser Thr Gly Pro Arg Arg Ser Thr Arg Ser Gly Thr Val 
    290                 295                 300                 


Asn Arg Ser Asn Gln Arg Thr Gly Arg Asn Gly Asp Pro Leu Leu Val 
305                 310                 315                 320 


Glu Ile Arg Met Lys Glu Asp Trp Val Leu Leu Asp Ala Arg Gly Leu 
                325                 330                 335     


Leu Arg Asn Leu Arg Trp Arg Glu Ser Lys Arg Gly Leu Ser Cys Asp 
            340                 345                 350         


His Glu Asp Leu Ser Leu Ser Gly Leu Leu Ala Leu Phe Ser Gly Asp 
        355                 360                 365             


Pro Val Ile Asp Pro Val Arg Asn Glu Val Val Phe Leu Tyr Gly Glu 
    370                 375                 380                 


Gly Ile Ile Pro Val Arg Ser Thr Lys Pro Val Gly Thr Arg Gln Ser 
385                 390                 395                 400 


Lys Lys Leu Leu Glu Arg Gln Ala Ser Met Gly Pro Leu Thr Leu Ile 
                405                 410                 415     


Ser Cys Asp Leu Gly Gln Thr Asn Leu Ile Ala Gly Arg Ala Ser Ala 
            420                 425                 430         


Ile Ser Leu Thr His Gly Ser Leu Gly Val Arg Ser Ser Val Arg Ile 
        435                 440                 445             


Glu Leu Asp Pro Glu Ile Ile Lys Ser Phe Glu Arg Leu Arg Lys Asp 
    450                 455                 460                 


Ala Asp Arg Leu Glu Thr Glu Ile Leu Thr Ala Ala Lys Glu Thr Leu 
465                 470                 475                 480 


Ser Asp Glu Gln Arg Gly Glu Val Asn Ser His Glu Lys Asp Ser Pro 
                485                 490                 495     


Gln Thr Ala Lys Ala Ser Leu Cys Arg Glu Leu Gly Leu His Pro Pro 
            500                 505                 510         


Ser Leu Pro Trp Gly Gln Met Gly Pro Ser Thr Thr Phe Ile Ala Asp 
        515                 520                 525             


Met Leu Ile Ser His Gly Arg Asp Asp Asp Ala Phe Leu Ser His Gly 
    530                 535                 540                 


Glu Phe Pro Thr Leu Glu Lys Arg Lys Lys Phe Asp Lys Arg Phe Cys 
545                 550                 555                 560 


Leu Glu Ser Arg Pro Leu Leu Ser Ser Glu Thr Arg Lys Ala Leu Asn 
                565                 570                 575     


Glu Ser Leu Trp Glu Val Lys Arg Thr Ser Ser Glu Tyr Ala Arg Leu 
            580                 585                 590         


Ser Gln Arg Lys Lys Glu Met Ala Arg Arg Ala Val Asn Phe Val Val 
        595                 600                 605             


Glu Ile Ser Arg Arg Lys Thr Gly Leu Ser Asn Val Ile Val Asn Ile 
    610                 615                 620                 


Glu Asp Leu Asn Val Arg Ile Phe His Gly Gly Gly Lys Gln Ala Pro 
625                 630                 635                 640 


Gly Trp Asp Gly Phe Phe Arg Pro Lys Ser Glu Asn Arg Trp Phe Ile 
                645                 650                 655     


Gln Ala Ile His Lys Ala Phe Ser Asp Leu Ala Ala His His Gly Ile 
            660                 665                 670         


Pro Val Ile Glu Ser Asp Pro Gln Arg Thr Ser Met Thr Cys Pro Glu 
        675                 680                 685             


Cys Gly His Cys Asp Ser Lys Asn Arg Asn Gly Val Arg Phe Leu Cys 
    690                 695                 700                 


Lys Gly Cys Gly Ala Ser Met Asp Ala Asp Phe Asp Ala Ala Cys Arg 
705                 710                 715                 720 


Asn Leu Glu Arg Val Ala Leu Thr Gly Lys Pro Met Pro Lys Pro Ser 
                725                 730                 735     


Thr Ser Cys Glu Arg Leu Leu Ser Ala Thr Thr Gly Lys Val Cys Ser 
            740                 745                 750         


Asp His Ser Leu Ser His Asp Ala Ile Glu Lys Ala Ser 
        755                 760                 765 


<210> 172
<211> 766
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 172
Met Glu Lys Glu Ile Thr Glu Leu Thr Lys Ile Arg Arg Glu Phe Pro 
1               5                   10                  15      


Asn Lys Lys Phe Ser Ser Thr Asp Met Lys Lys Ala Gly Lys Leu Leu 
            20                  25                  30          


Lys Ala Glu Gly Pro Asp Ala Val Arg Asp Phe Leu Asn Ser Cys Gln 
        35                  40                  45              


Glu Ile Ile Gly Asp Phe Lys Pro Pro Val Lys Thr Asn Ile Val Ser 
    50                  55                  60                  


Ile Ser Arg Pro Phe Glu Glu Trp Pro Val Ser Met Val Gly Arg Ala 
65                  70                  75                  80  


Ile Gln Glu Tyr Tyr Phe Ser Leu Thr Lys Glu Glu Leu Glu Ser Val 
                85                  90                  95      


His Pro Gly Thr Ser Ser Glu Asp His Lys Ser Phe Phe Asn Ile Thr 
            100                 105                 110         


Gly Leu Ser Asn Tyr Asn Tyr Thr Ser Val Gln Gly Leu Asn Leu Ile 
        115                 120                 125             


Phe Lys Asn Ala Lys Ala Ile Tyr Asp Gly Thr Leu Val Lys Ala Asn 
    130                 135                 140                 


Asn Lys Asn Lys Lys Leu Glu Lys Lys Phe Asn Glu Ile Asn His Lys 
145                 150                 155                 160 


Arg Ser Leu Glu Gly Leu Pro Ile Ile Thr Pro Asp Phe Glu Glu Pro 
                165                 170                 175     


Phe Asp Glu Asn Gly His Leu Asn Asn Pro Pro Gly Ile Asn Arg Asn 
            180                 185                 190         


Ile Tyr Gly Tyr Gln Gly Cys Ala Ala Lys Val Phe Val Pro Ser Lys 
        195                 200                 205             


His Lys Met Val Ser Leu Pro Lys Glu Tyr Glu Gly Tyr Asn Arg Asp 
    210                 215                 220                 


Pro Asn Leu Ser Leu Ala Gly Phe Arg Asn Arg Leu Glu Ile Pro Glu 
225                 230                 235                 240 


Gly Glu Pro Gly His Val Pro Trp Phe Gln Arg Met Asp Ile Pro Glu 
                245                 250                 255     


Gly Gln Ile Gly His Val Asn Lys Ile Gln Arg Phe Asn Phe Val His 
            260                 265                 270         


Gly Lys Asn Ser Gly Lys Val Lys Phe Ser Asp Lys Thr Gly Arg Val 
        275                 280                 285             


Lys Arg Tyr His His Ser Lys Tyr Lys Asp Ala Thr Lys Pro Tyr Lys 
    290                 295                 300                 


Phe Leu Glu Glu Ser Lys Lys Val Ser Ala Leu Asp Ser Ile Leu Ala 
305                 310                 315                 320 


Ile Ile Thr Ile Gly Asp Asp Trp Val Val Phe Asp Ile Arg Gly Leu 
                325                 330                 335     


Tyr Arg Asn Val Phe Tyr Arg Glu Leu Ala Gln Lys Gly Leu Thr Ala 
            340                 345                 350         


Val Gln Leu Leu Asp Leu Phe Thr Gly Asp Pro Val Ile Asp Pro Lys 
        355                 360                 365             


Lys Gly Val Val Thr Phe Ser Tyr Lys Glu Gly Val Val Pro Val Phe 
    370                 375                 380                 


Ser Gln Lys Ile Val Pro Arg Phe Lys Ser Arg Asp Thr Leu Glu Lys 
385                 390                 395                 400 


Leu Thr Ser Gln Gly Pro Val Ala Leu Leu Ser Val Asp Leu Gly Gln 
                405                 410                 415     


Asn Glu Pro Val Ala Ala Arg Val Cys Ser Leu Lys Asn Ile Asn Asp 
            420                 425                 430         


Lys Ile Thr Leu Asp Asn Ser Cys Arg Ile Ser Phe Leu Asp Asp Tyr 
        435                 440                 445             


Lys Lys Gln Ile Lys Asp Tyr Arg Asp Ser Leu Asp Glu Leu Glu Ile 
    450                 455                 460                 


Lys Ile Arg Leu Glu Ala Ile Asn Ser Leu Glu Thr Asn Gln Gln Val 
465                 470                 475                 480 


Glu Ile Arg Asp Leu Asp Val Phe Ser Ala Asp Arg Ala Lys Ala Asn 
                485                 490                 495     


Thr Val Asp Met Phe Asp Ile Asp Pro Asn Leu Ile Ser Trp Asp Ser 
            500                 505                 510         


Met Ser Asp Ala Arg Val Ser Thr Gln Ile Ser Asp Leu Tyr Leu Lys 
        515                 520                 525             


Asn Gly Gly Asp Glu Ser Arg Val Tyr Phe Glu Ile Asn Asn Lys Arg 
    530                 535                 540                 


Ile Lys Arg Ser Asp Tyr Asn Ile Ser Gln Leu Val Arg Pro Lys Leu 
545                 550                 555                 560 


Ser Asp Ser Thr Arg Lys Asn Leu Asn Asp Ser Ile Trp Lys Leu Lys 
                565                 570                 575     


Arg Thr Ser Glu Glu Tyr Leu Lys Leu Ser Lys Arg Lys Leu Glu Leu 
            580                 585                 590         


Ser Arg Ala Val Val Asn Tyr Thr Ile Arg Gln Ser Lys Leu Leu Ser 
        595                 600                 605             


Gly Ile Asn Asp Ile Val Ile Ile Leu Glu Asp Leu Asp Val Lys Lys 
    610                 615                 620                 


Lys Phe Asn Gly Arg Gly Ile Arg Asp Ile Gly Trp Asp Asn Phe Phe 
625                 630                 635                 640 


Ser Ser Arg Lys Glu Asn Arg Trp Phe Ile Pro Ala Phe His Lys Thr 
                645                 650                 655     


Phe Ser Glu Leu Ser Ser Asn Arg Gly Leu Cys Val Ile Glu Val Asn 
            660                 665                 670         


Pro Ala Trp Thr Ser Ala Thr Cys Pro Asp Cys Gly Phe Cys Ser Lys 
        675                 680                 685             


Glu Asn Arg Asp Gly Ile Asn Phe Thr Cys Arg Lys Cys Gly Val Ser 
    690                 695                 700                 


Tyr His Ala Asp Ile Asp Val Ala Thr Leu Asn Ile Ala Arg Val Ala 
705                 710                 715                 720 


Val Leu Gly Lys Pro Met Ser Gly Pro Ala Asp Arg Glu Arg Leu Gly 
                725                 730                 735     


Asp Thr Lys Lys Pro Arg Val Ala Arg Ser Arg Lys Thr Met Lys Arg 
            740                 745                 750         


Lys Asp Ile Ser Asn Ser Thr Val Glu Ala Met Val Thr Ala 
        755                 760                 765     


<210> 173
<211> 870
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 173
Met Leu Val Arg Thr Ser Thr Leu Val Gln Asp Asn Lys Asn Ser Arg 
1               5                   10                  15      


Ser Ala Ser Arg Ala Phe Leu Lys Lys Pro Lys Met Pro Lys Asn Lys 
            20                  25                  30          


His Ile Lys Glu Pro Thr Glu Leu Ala Lys Leu Ile Arg Glu Leu Phe 
        35                  40                  45              


Pro Gly Gln Arg Phe Thr Arg Ala Ile Asn Thr Gln Ala Gly Lys Ile 
    50                  55                  60                  


Leu Lys His Lys Gly Arg Asp Glu Val Val Glu Phe Leu Lys Asn Lys 
65                  70                  75                  80  


Gly Ile Asp Lys Glu Gln Phe Met Asp Phe Arg Pro Pro Thr Lys Ala 
                85                  90                  95      


Arg Ile Val Ala Thr Ser Gly Ala Ile Glu Glu Phe Ser Tyr Leu Arg 
            100                 105                 110         


Val Ser Met Ala Ile Gln Glu Cys Cys Phe Gly Lys Tyr Lys Phe Pro 
        115                 120                 125             


Lys Glu Lys Val Asn Gly Lys Leu Val Leu Glu Thr Val Gly Leu Thr 
    130                 135                 140                 


Lys Glu Glu Leu Asp Asp Phe Leu Pro Lys Lys Tyr Tyr Glu Asn Lys 
145                 150                 155                 160 


Lys Ser Arg Asp Arg Phe Phe Leu Lys Thr Gly Ile Cys Asp Tyr Gly 
                165                 170                 175     


Tyr Thr Tyr Ala Gln Gly Leu Asn Glu Ile Phe Arg Asn Thr Arg Ala 
            180                 185                 190         


Ile Tyr Glu Gly Val Phe Thr Lys Val Asn Asn Arg Asn Glu Lys Arg 
        195                 200                 205             


Arg Glu Lys Lys Asp Lys Tyr Asn Glu Glu Arg Arg Ser Lys Gly Leu 
    210                 215                 220                 


Ser Glu Glu Pro Tyr Asp Glu Asp Glu Ser Ala Thr Asp Glu Ser Gly 
225                 230                 235                 240 


His Leu Ile Asn Pro Pro Gly Val Asn Leu Asn Ile Trp Thr Cys Glu 
                245                 250                 255     


Gly Phe Cys Lys Gly Pro Tyr Val Thr Lys Leu Ser Gly Thr Pro Gly 
            260                 265                 270         


Tyr Glu Val Ile Leu Pro Lys Val Phe Asp Gly Tyr Asn Arg Asp Pro 
        275                 280                 285             


Asn Glu Ile Ile Ser Cys Gly Ile Thr Asp Arg Phe Ala Ile Pro Glu 
    290                 295                 300                 


Gly Glu Pro Gly His Ile Pro Trp His Gln Arg Leu Glu Ile Pro Glu 
305                 310                 315                 320 


Gly Gln Pro Gly Tyr Val Pro Gly His Gln Arg Phe Ala Asp Thr Gly 
                325                 330                 335     


Gln Asn Asn Ser Gly Lys Ala Asn Pro Asn Lys Lys Gly Arg Met Arg 
            340                 345                 350         


Lys Tyr Tyr Gly His Gly Thr Lys Tyr Thr Gln Pro Gly Glu Tyr Gln 
        355                 360                 365             


Glu Val Phe Arg Lys Gly His Arg Glu Gly Asn Lys Arg Arg Tyr Trp 
    370                 375                 380                 


Glu Glu Asp Phe Arg Ser Glu Ala His Asp Cys Ile Leu Tyr Val Ile 
385                 390                 395                 400 


His Ile Gly Asp Asp Trp Val Val Cys Asp Leu Arg Gly Pro Leu Arg 
                405                 410                 415     


Asp Ala Tyr Arg Arg Gly Leu Val Pro Lys Glu Gly Ile Thr Thr Gln 
            420                 425                 430         


Glu Leu Cys Asn Leu Phe Ser Gly Asp Pro Val Ile Asp Pro Lys His 
        435                 440                 445             


Gly Val Val Thr Phe Cys Tyr Lys Asn Gly Leu Val Arg Ala Gln Lys 
    450                 455                 460                 


Thr Ile Ser Ala Gly Lys Lys Ser Arg Glu Leu Leu Gly Ala Leu Thr 
465                 470                 475                 480 


Ser Gln Gly Pro Ile Ala Leu Ile Gly Val Asp Leu Gly Gln Thr Glu 
                485                 490                 495     


Pro Val Gly Ala Arg Ala Phe Ile Val Asn Gln Ala Arg Gly Ser Leu 
            500                 505                 510         


Ser Leu Pro Thr Leu Lys Gly Ser Phe Leu Leu Thr Ala Glu Asn Ser 
        515                 520                 525             


Ser Ser Trp Asn Val Phe Lys Gly Glu Ile Lys Ala Tyr Arg Glu Ala 
    530                 535                 540                 


Ile Asp Asp Leu Ala Ile Arg Leu Lys Lys Glu Ala Val Ala Thr Leu 
545                 550                 555                 560 


Ser Val Glu Gln Gln Thr Glu Ile Glu Ser Tyr Glu Ala Phe Ser Ala 
                565                 570                 575     


Glu Asp Ala Lys Gln Leu Ala Cys Glu Lys Phe Gly Val Asp Ser Ser 
            580                 585                 590         


Phe Ile Leu Trp Glu Asp Met Thr Pro Tyr His Thr Gly Pro Ala Thr 
        595                 600                 605             


Tyr Tyr Phe Ala Lys Gln Phe Leu Lys Lys Asn Gly Gly Asn Lys Ser 
    610                 615                 620                 


Leu Ile Glu Tyr Ile Pro Tyr Gln Lys Lys Lys Ser Lys Lys Thr Pro 
625                 630                 635                 640 


Lys Ala Val Leu Arg Ser Asp Tyr Asn Ile Ala Cys Cys Val Arg Pro 
                645                 650                 655     


Lys Leu Leu Pro Glu Thr Arg Lys Ala Leu Asn Glu Ala Ile Arg Ile 
            660                 665                 670         


Val Gln Lys Asn Ser Asp Glu Tyr Gln Arg Leu Ser Lys Arg Lys Leu 
        675                 680                 685             


Glu Phe Cys Arg Arg Val Val Asn Tyr Leu Val Arg Lys Ala Lys Lys 
    690                 695                 700                 


Leu Thr Gly Leu Glu Arg Val Ile Ile Ala Ile Glu Asp Leu Lys Ser 
705                 710                 715                 720 


Leu Glu Lys Phe Phe Thr Gly Ser Gly Lys Arg Asp Asn Gly Trp Ser 
                725                 730                 735     


Asn Phe Phe Arg Pro Lys Lys Glu Asn Arg Trp Phe Ile Pro Ala Phe 
            740                 745                 750         


His Lys Ala Phe Ser Glu Leu Ala Pro Asn Arg Gly Phe Tyr Val Ile 
        755                 760                 765             


Glu Cys Asn Pro Ala Arg Thr Ser Ile Thr Asp Pro Asp Cys Gly Tyr 
    770                 775                 780                 


Cys Asp Gly Asp Asn Arg Asp Gly Ile Lys Phe Glu Cys Lys Lys Cys 
785                 790                 795                 800 


Gly Ala Lys His His Thr Asp Leu Asp Val Ala Pro Leu Asn Ile Ala 
                805                 810                 815     


Ile Val Ala Val Thr Gly Arg Pro Met Pro Lys Thr Val Ser Asn Lys 
            820                 825                 830         


Ser Lys Arg Glu Arg Ser Gly Gly Glu Lys Ser Val Gly Ala Ser Arg 
        835                 840                 845             


Lys Arg Asn His Arg Lys Ser Lys Ala Asn Gln Glu Met Leu Asp Ala 
    850                 855                 860                 


Thr Ser Ser Ala Ala Glu 
865                 870 


<210> 174
<211> 830
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 174
Met Pro Lys Ile Lys Lys Pro Thr Glu Ile Ser Leu Leu Arg Lys Glu 
1               5                   10                  15      


Val Phe Pro Asp Leu His Phe Ala Lys Asp Arg Met Arg Ala Ala Ser 
            20                  25                  30          


Leu Val Leu Lys Asn Glu Gly Arg Glu Ala Ala Ile Glu Tyr Leu Arg 
        35                  40                  45              


Val Asn His Glu Asp Lys Pro Pro Asn Phe Met Pro Pro Ala Lys Thr 
    50                  55                  60                  


Pro Tyr Val Ala Leu Ser Arg Pro Leu Glu Gln Trp Pro Ile Ala Gln 
65                  70                  75                  80  


Ala Ser Ile Ala Ile Gln Lys Tyr Ile Phe Gly Leu Thr Lys Asp Glu 
                85                  90                  95      


Phe Ser Ala Thr Lys Lys Leu Leu Tyr Gly Asp Lys Ser Thr Pro Asn 
            100                 105                 110         


Thr Glu Ser Arg Lys Arg Trp Phe Glu Val Thr Gly Val Pro Asn Phe 
        115                 120                 125             


Gly Tyr Met Ser Ala Gln Gly Leu Asn Ala Ile Phe Ser Gly Ala Leu 
    130                 135                 140                 


Ala Arg Tyr Glu Gly Val Val Gln Lys Val Glu Asn Arg Asn Lys Lys 
145                 150                 155                 160 


Arg Phe Glu Lys Leu Ser Glu Lys Asn Gln Leu Leu Ile Glu Glu Gly 
                165                 170                 175     


Gln Pro Val Lys Asp Tyr Val Pro Asp Thr Ala Tyr His Thr Pro Glu 
            180                 185                 190         


Thr Leu Gln Lys Leu Ala Glu Asn Asn His Val Arg Val Glu Asp Leu 
        195                 200                 205             


Gly Asp Met Ile Asp Arg Leu Val His Pro Pro Gly Ile His Arg Ser 
    210                 215                 220                 


Ile Tyr Gly Tyr Gln Gln Val Pro Pro Phe Ala Tyr Asp Pro Asp Asn 
225                 230                 235                 240 


Pro Lys Gly Ile Ile Leu Pro Lys Ala Tyr Ala Gly Tyr Thr Arg Lys 
                245                 250                 255     


Pro His Asp Ile Ile Glu Ala Met Pro Asn Arg Leu Asn Ile Pro Glu 
            260                 265                 270         


Gly Gln Ala Gly Tyr Ile Pro Glu His Gln Arg Asp Lys Leu Lys Lys 
        275                 280                 285             


Gly Gly Arg Val Lys Arg Leu Arg Thr Thr Arg Val Arg Val Asp Ala 
    290                 295                 300                 


Thr Glu Thr Val Arg Ala Lys Ala Glu Ala Leu Asn Ala Glu Lys Ala 
305                 310                 315                 320 


Arg Leu Arg Gly Lys Glu Ala Ile Leu Ala Val Phe Gln Ile Glu Glu 
                325                 330                 335     


Asp Trp Ala Leu Ile Asp Met Arg Gly Leu Leu Arg Asn Val Tyr Met 
            340                 345                 350         


Arg Lys Leu Ile Ala Ala Gly Glu Leu Thr Pro Thr Thr Leu Leu Gly 
        355                 360                 365             


Tyr Phe Thr Glu Thr Leu Thr Leu Asp Pro Arg Arg Thr Glu Ala Thr 
    370                 375                 380                 


Phe Cys Tyr His Leu Arg Ser Glu Gly Ala Leu His Ala Glu Tyr Val 
385                 390                 395                 400 


Arg His Gly Lys Asn Thr Arg Glu Leu Leu Leu Asp Leu Thr Lys Asp 
                405                 410                 415     


Asn Glu Lys Ile Ala Leu Val Thr Ile Asp Leu Gly Gln Arg Asn Pro 
            420                 425                 430         


Leu Ala Ala Ala Ile Phe Arg Val Gly Arg Asp Ala Ser Gly Asp Leu 
        435                 440                 445             


Thr Glu Asn Ser Leu Glu Pro Val Ser Arg Met Leu Leu Pro Gln Ala 
    450                 455                 460                 


Tyr Leu Asp Gln Ile Lys Ala Tyr Arg Asp Ala Tyr Asp Ser Phe Arg 
465                 470                 475                 480 


Gln Asn Ile Trp Asp Thr Ala Leu Ala Ser Leu Thr Pro Glu Gln Gln 
                485                 490                 495     


Arg Gln Ile Leu Ala Tyr Glu Ala Tyr Thr Pro Asp Asp Ser Lys Glu 
            500                 505                 510         


Asn Val Leu Arg Leu Leu Leu Gly Gly Asn Val Met Pro Asp Asp Leu 
        515                 520                 525             


Pro Trp Glu Asp Met Thr Lys Asn Thr His Tyr Ile Ser Asp Arg Tyr 
    530                 535                 540                 


Leu Ala Asp Gly Gly Asp Pro Ser Lys Val Trp Phe Val Pro Gly Pro 
545                 550                 555                 560 


Arg Lys Arg Lys Lys Asn Ala Pro Pro Leu Lys Lys Pro Pro Lys Pro 
                565                 570                 575     


Arg Glu Leu Val Lys Arg Ser Asp His Asn Ile Ser His Leu Ser Glu 
            580                 585                 590         


Phe Arg Pro Gln Leu Leu Lys Glu Thr Arg Asp Ala Phe Glu Lys Ala 
        595                 600                 605             


Lys Ile Asp Thr Glu Arg Gly His Val Gly Tyr Gln Lys Leu Ser Thr 
    610                 615                 620                 


Arg Lys Asp Gln Leu Cys Lys Glu Ile Leu Asn Trp Leu Glu Ala Glu 
625                 630                 635                 640 


Ala Val Arg Leu Thr Arg Cys Lys Thr Met Val Leu Gly Leu Glu Asp 
                645                 650                 655     


Leu Asn Gly Pro Phe Phe Asn Gln Gly Lys Gly Lys Val Arg Gly Trp 
            660                 665                 670         


Val Ser Phe Phe Arg Gln Lys Gln Glu Asn Arg Trp Ile Val Asn Gly 
        675                 680                 685             


Phe Arg Lys Asn Ala Leu Ala Arg Ala His Asp Lys Gly Lys Tyr Ile 
    690                 695                 700                 


Leu Glu Leu Trp Pro Ser Trp Thr Ser Gln Thr Cys Pro Lys Cys Lys 
705                 710                 715                 720 


His Val His Ala Asp Asn Arg His Gly Asp Asp Phe Val Cys Leu Gln 
                725                 730                 735     


Cys Gly Ala Arg Leu His Ala Asp Ala Glu Val Ala Thr Trp Asn Leu 
            740                 745                 750         


Ala Val Val Ala Ile Gln Gly His Ser Leu Pro Gly Pro Val Arg Glu 
        755                 760                 765             


Lys Ser Asn Asp Arg Lys Lys Ser Gly Ser Ala Arg Lys Ser Lys Lys 
    770                 775                 780                 


Ala Asn Glu Ser Gly Lys Val Val Gly Ala Trp Ala Ala Gln Ala Thr 
785                 790                 795                 800 


Pro Lys Arg Ala Thr Ser Lys Lys Glu Thr Gly Thr Ala Arg Asn Pro 
                805                 810                 815     


Val Tyr Asn Pro Leu Glu Thr Gln Ala Ser Cys Pro Ala Pro 
            820                 825                 830 


<210> 175
<211> 790
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 175
Met Thr Pro Ser Pro Gln Ile Ala Arg Leu Val Glu Thr Pro Leu Ala 
1               5                   10                  15      


Ala Ala Leu Lys Ala His His Pro Gly Lys Lys Phe Arg Ser Asp Tyr 
            20                  25                  30          


Leu Lys Lys Ala Gly Lys Ile Leu Lys Asp Gln Gly Val Glu Ala Ala 
        35                  40                  45              


Met Ala His Leu Asp Gly Lys Asp Gln Ala Glu Pro Pro Asn Phe Lys 
    50                  55                  60                  


Pro Pro Ala Lys Cys Arg Ile Val Ala Arg Ser Arg Glu Phe Ser Glu 
65                  70                  75                  80  


Trp Pro Ile Val Lys Ala Ser Val Glu Ile Gln Lys Tyr Ile Tyr Gly 
                85                  90                  95      


Leu Thr Leu Glu Glu Arg Lys Ala Cys Asp Pro Gly Lys Ser Ser Ala 
            100                 105                 110         


Ser His Lys Ala Trp Phe Ala Lys Thr Gly Val Asn Thr Phe Gly Tyr 
        115                 120                 125             


Ser Ser Val Gln Gly Phe Asn Leu Ile Phe Gly His Thr Leu Gly Arg 
    130                 135                 140                 


Tyr Asp Gly Val Leu Val Lys Thr Glu Asn Leu Asn Lys Lys Arg Ala 
145                 150                 155                 160 


Glu Lys Asn Glu Arg Phe Arg Ala Lys Ala Leu Ala Glu Gly Arg Ala 
                165                 170                 175     


Glu Pro Val Cys Pro Pro Leu Val Thr Ala Thr Asn Asp Thr Gly Gln 
            180                 185                 190         


Asp Val Thr Leu Glu Asp Gly Arg Val Val Arg Pro Gly Gln Leu Leu 
        195                 200                 205             


Gln Pro Pro Gly Ile Asn Pro Asn Ile Tyr Ala Tyr Gln Gln Val Ser 
    210                 215                 220                 


Pro Lys Ala Tyr Val Pro Gly Ile Ile Glu Leu Pro Glu Glu Phe Gln 
225                 230                 235                 240 


Gly Tyr Ser Arg Asp Pro Asn Ala Val Ile Leu Pro Leu Val Pro Arg 
                245                 250                 255     


Asp Arg Leu Ser Ile Pro Lys Gly Gln Pro Gly Tyr Val Pro Glu Pro 
            260                 265                 270         


His Arg Glu Gly Leu Thr Gly Arg Lys Asp Arg Arg Met Arg Arg Tyr 
        275                 280                 285             


Tyr Glu Thr Glu Arg Gly Thr Lys Leu Lys Arg Pro Pro Leu Thr Ala 
    290                 295                 300                 


Lys Gly Arg Ala Asp Lys Ala Asn Glu Ala Leu Leu Val Val Val Arg 
305                 310                 315                 320 


Ile Asp Ser Asp Trp Val Val Met Asp Val Arg Gly Leu Leu Arg Asn 
                325                 330                 335     


Ala Arg Trp Arg Arg Leu Val Ser Lys Glu Gly Ile Thr Leu Asn Gly 
            340                 345                 350         


Leu Leu Asp Leu Phe Thr Gly Asp Pro Val Leu Asn Pro Lys Asp Cys 
        355                 360                 365             


Ser Val Ser Arg Asp Thr Gly Asp Pro Val Asn Asp Pro Arg His Gly 
    370                 375                 380                 


Val Val Thr Phe Cys Tyr Lys Leu Gly Val Val Asp Val Cys Ser Lys 
385                 390                 395                 400 


Asp Arg Pro Ile Lys Gly Phe Arg Thr Lys Glu Val Leu Glu Arg Leu 
                405                 410                 415     


Thr Ser Ser Gly Thr Val Gly Met Val Ser Ile Asp Leu Gly Gln Thr 
            420                 425                 430         


Asn Pro Val Ala Ala Ala Val Ser Arg Val Thr Lys Gly Leu Gln Ala 
        435                 440                 445             


Glu Thr Leu Glu Thr Phe Thr Leu Pro Asp Asp Leu Leu Gly Lys Val 
    450                 455                 460                 


Arg Ala Tyr Arg Ala Lys Thr Asp Arg Met Glu Glu Gly Phe Arg Arg 
465                 470                 475                 480 


Asn Ala Leu Arg Lys Leu Thr Ala Glu Gln Gln Ala Glu Ile Thr Arg 
                485                 490                 495     


Tyr Asn Asp Ala Thr Glu Gln Gln Ala Lys Ala Leu Val Cys Ser Thr 
            500                 505                 510         


Tyr Gly Ile Gly Pro Glu Glu Val Pro Trp Glu Arg Met Thr Ser Asn 
        515                 520                 525             


Thr Thr Tyr Ile Ser Asp His Ile Leu Asp His Gly Gly Asp Pro Asp 
    530                 535                 540                 


Thr Val Phe Phe Met Ala Thr Lys Arg Gly Gln Asn Lys Pro Thr Leu 
545                 550                 555                 560 


His Lys Arg Lys Asp Lys Ala Trp Gly Gln Lys Phe Arg Pro Ala Ile 
                565                 570                 575     


Ser Val Glu Thr Arg Leu Ala Arg Gln Ala Ala Glu Trp Glu Leu Arg 
            580                 585                 590         


Arg Ala Ser Leu Glu Phe Gln Lys Leu Ser Val Trp Lys Thr Glu Leu 
        595                 600                 605             


Cys Arg Gln Ala Val Asn Tyr Val Met Glu Arg Thr Lys Lys Arg Thr 
    610                 615                 620                 


Gln Cys Asp Val Ile Ile Pro Val Ile Glu Asp Leu Pro Val Pro Leu 
625                 630                 635                 640 


Phe His Gly Ser Gly Lys Arg Asp Pro Gly Trp Ala Asn Phe Phe Val 
                645                 650                 655     


His Lys Arg Glu Asn Arg Trp Phe Ile Asp Gly Leu His Lys Ala Phe 
            660                 665                 670         


Ser Glu Leu Gly Lys His Arg Gly Ile Tyr Val Phe Glu Val Cys Pro 
        675                 680                 685             


Gln Arg Thr Ser Ile Thr Cys Pro Lys Cys Gly His Cys Asp Pro Asp 
    690                 695                 700                 


Asn Arg Asp Gly Glu Lys Phe Val Cys Leu Ser Cys Gln Ala Thr Leu 
705                 710                 715                 720 


Asn Ala Asp Leu Asp Val Ala Thr Thr Asn Leu Val Arg Val Ala Leu 
                725                 730                 735     


Thr Gly Lys Val Met Pro Arg Ser Glu Arg Ser Gly Asp Ala Gln Thr 
            740                 745                 750         


Pro Gly Pro Ala Arg Lys Ala Arg Thr Gly Lys Ile Lys Gly Ser Lys 
        755                 760                 765             


Pro Thr Ser Ala Pro Gln Gly Ala Thr Gln Thr Asp Ala Lys Ala His 
    770                 775                 780                 


Leu Ser Gln Thr Gly Val 
785                 790 


<210> 176
<211> 790
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 176
Met Thr Pro Ser Pro Gln Ile Ala Arg Leu Val Glu Thr Pro Leu Ala 
1               5                   10                  15      


Ala Ala Leu Lys Ala His His Pro Gly Lys Lys Phe Arg Ser Asp Tyr 
            20                  25                  30          


Leu Lys Lys Ala Gly Lys Ile Leu Lys Asp Gln Gly Val Glu Ala Ala 
        35                  40                  45              


Met Ala His Leu Asp Gly Lys Asp Gln Ala Glu Pro Pro Asn Phe Lys 
    50                  55                  60                  


Pro Pro Ala Lys Cys Arg Ile Val Ala Arg Ser Arg Glu Phe Ser Glu 
65                  70                  75                  80  


Trp Pro Ile Val Lys Ala Ser Val Glu Ile Gln Lys Tyr Ile Tyr Gly 
                85                  90                  95      


Leu Thr Leu Glu Glu Arg Lys Ala Cys Asp Pro Gly Lys Ser Ser Ala 
            100                 105                 110         


Ser His Lys Ala Trp Phe Ala Lys Thr Gly Val Asn Thr Phe Gly Tyr 
        115                 120                 125             


Ser Ser Val Gln Gly Phe Asn Leu Ile Phe Gly His Thr Leu Gly Arg 
    130                 135                 140                 


Tyr Asp Gly Val Leu Val Lys Thr Glu Asn Leu Asn Lys Lys Arg Ala 
145                 150                 155                 160 


Glu Lys Asn Glu Arg Phe Arg Ala Lys Ala Leu Ala Glu Gly Arg Ala 
                165                 170                 175     


Glu Pro Val Cys Pro Pro Leu Val Thr Ala Thr Asn Asp Thr Gly Gln 
            180                 185                 190         


Asp Val Thr Leu Glu Asp Gly Arg Val Val Arg Pro Gly Gln Leu Leu 
        195                 200                 205             


Gln Pro Pro Gly Ile Asn Pro Asn Ile Tyr Ala Tyr Gln Gln Val Ser 
    210                 215                 220                 


Pro Lys Ala Tyr Val Pro Gly Ile Ile Glu Leu Pro Glu Glu Phe Gln 
225                 230                 235                 240 


Gly Tyr Ser Arg Asp Pro Asn Ala Val Ile Leu Pro Leu Val Pro Arg 
                245                 250                 255     


Asp Arg Leu Ser Ile Pro Lys Gly Gln Pro Gly Tyr Val Pro Glu Pro 
            260                 265                 270         


His Arg Glu Gly Leu Thr Gly Arg Lys Asp Arg Arg Met Arg Arg Tyr 
        275                 280                 285             


Tyr Glu Thr Glu Arg Gly Thr Lys Leu Lys Arg Pro Pro Leu Thr Ala 
    290                 295                 300                 


Lys Gly Arg Ala Asp Lys Ala Asn Glu Ala Leu Leu Val Val Val Arg 
305                 310                 315                 320 


Ile Asp Ser Asp Trp Val Val Met Asp Val Arg Gly Leu Leu Arg Asn 
                325                 330                 335     


Ala Arg Trp Arg Arg Leu Val Ser Lys Glu Gly Ile Thr Leu Asn Gly 
            340                 345                 350         


Leu Leu Asp Leu Phe Thr Gly Asp Pro Val Leu Asn Pro Lys Asp Cys 
        355                 360                 365             


Ser Val Ser Arg Asp Thr Gly Asp Pro Val Asn Asp Pro Arg His Gly 
    370                 375                 380                 


Val Val Thr Phe Cys Tyr Lys Leu Gly Val Val Asp Val Cys Ser Lys 
385                 390                 395                 400 


Asp Arg Pro Ile Lys Gly Phe Arg Thr Lys Glu Val Leu Glu Arg Leu 
                405                 410                 415     


Thr Ser Ser Gly Thr Val Gly Met Val Ser Ile Asp Leu Gly Gln Thr 
            420                 425                 430         


Asn Pro Val Ala Ala Ala Val Ser Arg Val Thr Lys Gly Leu Gln Ala 
        435                 440                 445             


Glu Thr Leu Glu Thr Phe Thr Leu Pro Asp Asp Leu Leu Gly Lys Val 
    450                 455                 460                 


Arg Ala Tyr Arg Ala Lys Thr Asp Arg Met Glu Glu Gly Phe Arg Arg 
465                 470                 475                 480 


Asn Ala Leu Arg Lys Leu Thr Ala Glu Gln Gln Ala Glu Ile Thr Arg 
                485                 490                 495     


Tyr Asn Asp Ala Thr Glu Gln Gln Ala Lys Ala Leu Val Cys Ser Thr 
            500                 505                 510         


Tyr Gly Ile Gly Pro Glu Glu Val Pro Trp Glu Arg Met Thr Ser Asn 
        515                 520                 525             


Thr Thr Tyr Ile Ser Asp His Ile Leu Asp His Gly Gly Asp Pro Asp 
    530                 535                 540                 


Thr Val Phe Phe Met Ala Thr Lys Arg Gly Gln Asn Lys Pro Thr Leu 
545                 550                 555                 560 


His Lys Arg Lys Asp Lys Ala Trp Gly Gln Lys Phe Arg Pro Ala Ile 
                565                 570                 575     


Ser Val Glu Thr Arg Leu Ala Arg Gln Ala Ala Glu Trp Glu Leu Arg 
            580                 585                 590         


Arg Ala Ser Leu Glu Phe Gln Lys Leu Ser Val Trp Lys Thr Glu Leu 
        595                 600                 605             


Cys Arg Gln Ala Val Asn Tyr Val Met Glu Arg Thr Lys Lys Arg Thr 
    610                 615                 620                 


Gln Cys Asp Val Ile Ile Pro Val Ile Glu Asp Leu Pro Val Pro Leu 
625                 630                 635                 640 


Phe His Gly Ser Gly Lys Arg Asp Pro Gly Trp Ala Asn Phe Phe Val 
                645                 650                 655     


His Lys Arg Glu Asn Arg Trp Phe Ile Asp Gly Leu His Lys Ala Phe 
            660                 665                 670         


Ser Glu Leu Gly Lys His Arg Gly Ile Tyr Val Phe Glu Val Cys Pro 
        675                 680                 685             


Gln Arg Thr Ser Ile Thr Cys Pro Lys Cys Gly His Cys Asp Pro Asp 
    690                 695                 700                 


Asn Arg Asp Gly Glu Lys Phe Val Cys Leu Ser Cys Gln Ala Thr Leu 
705                 710                 715                 720 


His Ala Asp Leu Asp Val Ala Thr Thr Asn Leu Val Arg Val Ala Leu 
                725                 730                 735     


Thr Gly Lys Val Met Pro Arg Ser Glu Arg Ser Gly Asp Ala Gln Thr 
            740                 745                 750         


Pro Gly Pro Ala Arg Lys Ala Arg Thr Gly Lys Ile Lys Gly Ser Lys 
        755                 760                 765             


Pro Thr Ser Ala Pro Gln Gly Ala Thr Gln Thr Asp Ala Lys Ala His 
    770                 775                 780                 


Leu Ser Gln Thr Gly Val 
785                 790 


<210> 177
<211> 782
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 177
Met Lys Thr Glu Lys Pro Lys Thr Ala Leu Thr Leu Leu Arg Glu Glu 
1               5                   10                  15      


Val Phe Pro Gly Lys Lys Tyr Arg Leu Asp Val Leu Lys Glu Ala Gly 
            20                  25                  30          


Lys Lys Leu Ser Thr Lys Gly Arg Glu Ala Thr Ile Glu Phe Leu Thr 
        35                  40                  45              


Gly Lys Asp Glu Glu Arg Pro Gln Asn Phe Gln Pro Pro Ala Lys Thr 
    50                  55                  60                  


Ser Ile Val Ala Gln Ser Arg Pro Phe Asp Gln Trp Pro Ile Val Gln 
65                  70                  75                  80  


Val Ser Leu Ala Val Gln Lys Tyr Ile Tyr Gly Leu Thr Gln Ser Glu 
                85                  90                  95      


Phe Glu Ala Asn Lys Lys Ala Leu Tyr Gly Glu Thr Gly Lys Ala Ile 
            100                 105                 110         


Ser Thr Glu Ser Arg Arg Ala Trp Phe Glu Ala Thr Gly Val Asp Asn 
        115                 120                 125             


Phe Gly Phe Thr Ala Ala Gln Gly Ile Asn Pro Ile Phe Ser Gln Ala 
    130                 135                 140                 


Val Ala Arg Tyr Glu Gly Val Ile Lys Lys Val Glu Asn Arg Asn Glu 
145                 150                 155                 160 


Lys Lys Leu Lys Lys Leu Thr Lys Lys Asn Leu Leu Arg Leu Glu Ser 
                165                 170                 175     


Gly Glu Glu Ile Glu Asp Phe Glu Pro Glu Ala Thr Phe Asn Glu Glu 
            180                 185                 190         


Gly Arg Leu Leu Gln Pro Pro Gly Ala Asn Pro Asn Ile Tyr Cys Tyr 
        195                 200                 205             


Gln Gln Ile Ser Pro Arg Ile Tyr Asp Pro Ser Asp Pro Lys Gly Val 
    210                 215                 220                 


Ile Leu Pro Gln Ile Tyr Ala Gly Tyr Asp Arg Lys Pro Glu Asp Ile 
225                 230                 235                 240 


Ile Ser Ala Gly Val Pro Asn Arg Leu Ala Ile Pro Glu Gly Gln Pro 
                245                 250                 255     


Gly Tyr Ile Pro Glu His Gln Arg Ala Gly Leu Lys Thr Gln Gly Arg 
            260                 265                 270         


Ile Arg Cys Arg Ala Ser Val Glu Ala Lys Ala Arg Ala Ala Ile Leu 
        275                 280                 285             


Ala Val Val His Leu Gly Glu Asp Trp Val Val Leu Asp Leu Arg Gly 
    290                 295                 300                 


Leu Leu Arg Asn Val Tyr Trp Arg Lys Leu Ala Ser Pro Gly Thr Leu 
305                 310                 315                 320 


Thr Leu Lys Gly Leu Leu Asp Phe Phe Thr Gly Gly Pro Val Leu Asp 
                325                 330                 335     


Ala Arg Arg Gly Ile Ala Thr Phe Ser Tyr Thr Leu Lys Ser Ala Ala 
            340                 345                 350         


Ala Val His Ala Glu Asn Thr Tyr Lys Gly Lys Gly Thr Arg Glu Val 
        355                 360                 365             


Leu Leu Lys Leu Thr Glu Asn Asn Ser Val Ala Leu Val Thr Val Asp 
    370                 375                 380                 


Leu Gly Gln Arg Asn Pro Leu Ala Ala Met Ile Ala Arg Val Ser Arg 
385                 390                 395                 400 


Thr Ser Gln Gly Asp Leu Thr Tyr Pro Glu Ser Val Glu Pro Leu Thr 
                405                 410                 415     


Arg Leu Phe Leu Pro Asp Pro Phe Leu Glu Glu Val Arg Lys Tyr Arg 
            420                 425                 430         


Ser Ser Tyr Asp Ala Leu Arg Leu Ser Ile Arg Glu Ala Ala Ile Ala 
        435                 440                 445             


Ser Leu Thr Pro Glu Gln Gln Ala Glu Ile Arg Tyr Ile Glu Lys Phe 
    450                 455                 460                 


Ser Ala Gly Asp Ala Lys Lys Asn Val Ala Glu Val Phe Gly Ile Asp 
465                 470                 475                 480 


Pro Thr Gln Leu Pro Trp Asp Ala Met Thr Pro Arg Thr Thr Tyr Ile 
                485                 490                 495     


Ser Asp Leu Phe Leu Arg Met Gly Gly Asp Arg Ser Arg Val Phe Phe 
            500                 505                 510         


Glu Val Pro Pro Lys Lys Ala Lys Lys Ala Pro Lys Lys Pro Pro Lys 
        515                 520                 525             


Lys Pro Ala Gly Pro Arg Ile Val Lys Arg Thr Asp Gly Met Ile Ala 
    530                 535                 540                 


Arg Leu Arg Glu Ile Arg Pro Arg Leu Ser Ala Glu Thr Asn Lys Ala 
545                 550                 555                 560 


Phe Gln Glu Ala Arg Trp Glu Gly Glu Arg Ser Asn Val Ala Phe Gln 
                565                 570                 575     


Lys Leu Ser Val Arg Arg Lys Gln Phe Ala Arg Thr Val Val Asn His 
            580                 585                 590         


Leu Val Gln Thr Ala Gln Lys Met Ser Arg Cys Asp Thr Val Val Leu 
        595                 600                 605             


Gly Ile Glu Asp Leu Asn Val Pro Phe Phe His Gly Arg Gly Lys Tyr 
    610                 615                 620                 


Gln Pro Gly Trp Glu Gly Phe Phe Arg Gln Lys Lys Glu Asn Arg Trp 
625                 630                 635                 640 


Leu Ile Asn Asp Met His Lys Ala Leu Ser Glu Arg Gly Pro His Arg 
                645                 650                 655     


Gly Gly Tyr Val Leu Glu Leu Thr Pro Phe Trp Thr Ser Leu Arg Cys 
            660                 665                 670         


Pro Lys Cys Gly His Thr Asp Ser Ala Asn Arg Asp Gly Asp Asp Phe 
        675                 680                 685             


Val Cys Val Lys Cys Gly Ala Lys Leu His Ser Asp Leu Glu Val Ala 
    690                 695                 700                 


Thr Ala Asn Leu Ala Leu Val Ala Ile Thr Gly Gln Ser Ile Pro Arg 
705                 710                 715                 720 


Pro Pro Arg Glu Gln Ser Ser Gly Lys Lys Ser Thr Gly Thr Ala Arg 
                725                 730                 735     


Met Lys Lys Thr Ser Gly Glu Thr Gln Gly Lys Gly Ser Lys Ala Cys 
            740                 745                 750         


Val Ser Glu Ala Leu Asn Lys Ile Glu Gln Gly Thr Ala Arg Asp Pro 
        755                 760                 765             


Val Tyr Asn Pro Leu Asn Ser Gln Val Ser Cys Pro Ala Pro 
    770                 775                 780         


<210> 178
<211> 774
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 178
Val Tyr Asn Pro Asp Met Lys Lys Pro Asn Asn Ile Arg Arg Ile Arg 
1               5                   10                  15      


Glu Glu His Phe Glu Gly Leu Cys Phe Gly Lys Asp Val Leu Thr Lys 
            20                  25                  30          


Ala Gly Lys Ile Tyr Glu Lys Asp Gly Glu Glu Ala Ala Ile Asp Phe 
        35                  40                  45              


Leu Met Gly Lys Asp Glu Glu Asp Pro Pro Asn Phe Lys Pro Pro Ala 
    50                  55                  60                  


Lys Thr Thr Ile Val Ala Gln Ser Arg Pro Phe Asp Gln Trp Pro Ile 
65                  70                  75                  80  


Tyr Gln Val Ser Gln Ala Val Gln Glu Arg Val Phe Ala Tyr Thr Glu 
                85                  90                  95      


Glu Glu Phe Asn Ala Ser Lys Glu Ala Leu Phe Ser Gly Asp Ile Ser 
            100                 105                 110         


Ser Lys Ser Arg Asp Phe Trp Phe Lys Thr Asn Asn Ile Ser Asp Gln 
        115                 120                 125             


Gly Ile Gly Ala Gln Gly Leu Asn Thr Ile Leu Ser His Ala Phe Ser 
    130                 135                 140                 


Arg Tyr Ser Gly Val Ile Lys Lys Val Glu Asn Arg Asn Lys Lys Arg 
145                 150                 155                 160 


Leu Lys Lys Leu Ser Lys Lys Asn Gln Leu Lys Ile Glu Glu Gly Leu 
                165                 170                 175     


Glu Ile Leu Glu Phe Lys Pro Asp Ser Ala Phe Asn Glu Asn Gly Leu 
            180                 185                 190         


Leu Ala Gln Pro Pro Gly Ile Asn Pro Asn Ile Tyr Gly Tyr Gln Ala 
        195                 200                 205             


Val Thr Pro Phe Val Phe Asp Pro Asp Asn Pro Gly Asp Val Ile Leu 
    210                 215                 220                 


Pro Lys Gln Tyr Glu Gly Tyr Ser Arg Lys Pro Asp Asp Ile Ile Glu 
225                 230                 235                 240 


Lys Gly Pro Ser Arg Leu Asp Ile Pro Lys Gly Gln Pro Gly Tyr Val 
                245                 250                 255     


Pro Glu His Gln Arg Lys Asn Leu Lys Lys Lys Gly Arg Val Arg Leu 
            260                 265                 270         


Tyr Arg Arg Thr Pro Pro Lys Thr Lys Ala Leu Ala Ser Ile Leu Ala 
        275                 280                 285             


Val Leu Gln Ile Gly Lys Asp Trp Val Leu Phe Asp Met Arg Gly Leu 
    290                 295                 300                 


Leu Arg Ser Val Tyr Met Arg Glu Ala Ala Thr Pro Gly Gln Ile Ser 
305                 310                 315                 320 


Ala Lys Asp Leu Leu Asp Thr Phe Thr Gly Cys Pro Val Leu Asn Thr 
                325                 330                 335     


Arg Thr Gly Glu Phe Thr Phe Cys Tyr Lys Leu Arg Ser Glu Gly Ala 
            340                 345                 350         


Leu His Ala Arg Lys Ile Tyr Thr Lys Gly Glu Thr Arg Thr Leu Leu 
        355                 360                 365             


Thr Ser Leu Thr Ser Glu Asn Asn Thr Ile Ala Leu Val Thr Val Asp 
    370                 375                 380                 


Leu Gly Gln Arg Asn Pro Ala Ala Ile Met Ile Ser Arg Leu Ser Arg 
385                 390                 395                 400 


Lys Glu Glu Leu Ser Glu Lys Asp Ile Gln Pro Val Ser Arg Arg Leu 
                405                 410                 415     


Leu Pro Asp Arg Tyr Leu Asn Glu Leu Lys Arg Tyr Arg Asp Ala Tyr 
            420                 425                 430         


Asp Ala Phe Arg Gln Glu Val Arg Asp Glu Ala Phe Thr Ser Leu Cys 
        435                 440                 445             


Pro Glu His Gln Glu Gln Val Gln Gln Tyr Glu Ala Leu Thr Pro Glu 
    450                 455                 460                 


Lys Ala Lys Asn Leu Val Leu Lys His Phe Phe Gly Thr His Asp Pro 
465                 470                 475                 480 


Asp Leu Pro Trp Asp Asp Met Thr Ser Asn Thr His Tyr Ile Ala Asn 
                485                 490                 495     


Leu Tyr Leu Glu Arg Gly Gly Asp Pro Ser Lys Val Phe Phe Thr Arg 
            500                 505                 510         


Pro Leu Lys Lys Asp Ser Lys Ser Lys Lys Pro Arg Lys Pro Thr Lys 
        515                 520                 525             


Arg Thr Asp Ala Ser Ile Ser Arg Leu Pro Glu Ile Arg Pro Lys Met 
    530                 535                 540                 


Pro Glu Asp Ala Arg Lys Ala Phe Glu Lys Ala Lys Trp Glu Ile Tyr 
545                 550                 555                 560 


Thr Gly His Glu Lys Phe Pro Lys Leu Ala Lys Arg Val Asn Gln Leu 
                565                 570                 575     


Cys Arg Glu Ile Ala Asn Trp Ile Glu Lys Glu Ala Lys Arg Leu Thr 
            580                 585                 590         


Leu Cys Asp Thr Val Val Val Gly Ile Glu Asp Leu Ser Leu Pro Pro 
        595                 600                 605             


Lys Arg Gly Lys Gly Lys Phe Gln Glu Thr Trp Gln Gly Phe Phe Arg 
    610                 615                 620                 


Gln Lys Phe Glu Asn Arg Trp Val Ile Asp Thr Leu Lys Lys Ala Ile 
625                 630                 635                 640 


Gln Asn Arg Ala His Asp Lys Gly Lys Tyr Val Leu Gly Leu Ala Pro 
                645                 650                 655     


Tyr Trp Thr Ser Gln Arg Cys Pro Ala Cys Gly Phe Ile His Lys Ser 
            660                 665                 670         


Asn Arg Asn Gly Asp His Phe Lys Cys Leu Lys Cys Glu Ala Leu Phe 
        675                 680                 685             


His Ala Asp Ser Glu Val Ala Thr Trp Asn Leu Ala Leu Val Ala Val 
    690                 695                 700                 


Leu Gly Lys Gly Ile Thr Asn Pro Asp Ser Lys Lys Pro Ser Gly Gln 
705                 710                 715                 720 


Lys Lys Thr Gly Thr Thr Arg Lys Lys Gln Ile Lys Gly Lys Asn Lys 
                725                 730                 735     


Gly Lys Glu Thr Val Asn Val Pro Pro Thr Thr Gln Glu Val Glu Asp 
            740                 745                 750         


Ile Ile Ala Phe Phe Glu Lys Asp Asp Glu Thr Val Arg Asn Pro Val 
        755                 760                 765             


Tyr Lys Pro Thr Gly Thr 
    770                 


<210> 179
<211> 769
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 179
Met Lys Lys Pro Asn Asn Ile Arg Arg Ile Arg Glu Glu His Phe Glu 
1               5                   10                  15      


Gly Leu Cys Phe Gly Lys Asp Val Leu Thr Lys Ala Gly Lys Ile Tyr 
            20                  25                  30          


Glu Lys Asp Gly Glu Glu Ala Ala Ile Asp Phe Leu Met Gly Lys Asp 
        35                  40                  45              


Glu Glu Asp Pro Pro Asn Phe Lys Pro Pro Ala Lys Thr Thr Ile Val 
    50                  55                  60                  


Ala Gln Ser Arg Pro Phe Asp Gln Trp Pro Ile Tyr Gln Val Ser Gln 
65                  70                  75                  80  


Ala Val Gln Glu Arg Val Phe Ala Tyr Thr Glu Glu Glu Phe Asn Ala 
                85                  90                  95      


Ser Lys Glu Ala Leu Phe Ser Gly Asp Ile Ser Ser Lys Ser Arg Asp 
            100                 105                 110         


Phe Trp Phe Lys Thr Asn Asn Ile Ser Asp Gln Gly Ile Gly Ala Gln 
        115                 120                 125             


Gly Leu Asn Thr Ile Leu Ser His Ala Phe Ser Arg Tyr Ser Gly Val 
    130                 135                 140                 


Ile Lys Lys Val Glu Asn Arg Asn Lys Lys Arg Leu Lys Lys Leu Ser 
145                 150                 155                 160 


Lys Lys Asn Gln Leu Lys Ile Glu Glu Gly Leu Glu Ile Leu Glu Phe 
                165                 170                 175     


Lys Pro Asp Ser Ala Phe Asn Glu Asn Gly Leu Leu Ala Gln Pro Pro 
            180                 185                 190         


Gly Ile Asn Pro Asn Ile Tyr Gly Tyr Gln Ala Val Thr Pro Phe Val 
        195                 200                 205             


Phe Asp Pro Asp Asn Pro Gly Asp Val Ile Leu Pro Lys Gln Tyr Glu 
    210                 215                 220                 


Gly Tyr Ser Arg Lys Pro Asp Asp Ile Ile Glu Lys Gly Pro Ser Arg 
225                 230                 235                 240 


Leu Asp Ile Pro Lys Gly Gln Pro Gly Tyr Val Pro Glu His Gln Arg 
                245                 250                 255     


Lys Asn Leu Lys Lys Lys Gly Arg Val Arg Leu Tyr Arg Arg Thr Pro 
            260                 265                 270         


Pro Lys Thr Lys Ala Leu Ala Ser Ile Leu Ala Val Leu Gln Ile Gly 
        275                 280                 285             


Lys Asp Trp Val Leu Phe Asp Met Arg Gly Leu Leu Arg Ser Val Tyr 
    290                 295                 300                 


Met Arg Glu Ala Ala Thr Pro Gly Gln Ile Ser Ala Lys Asp Leu Leu 
305                 310                 315                 320 


Asp Thr Phe Thr Gly Cys Pro Val Leu Asn Thr Arg Thr Gly Glu Phe 
                325                 330                 335     


Thr Phe Cys Tyr Lys Leu Arg Ser Glu Gly Ala Leu His Ala Arg Lys 
            340                 345                 350         


Ile Tyr Thr Lys Gly Glu Thr Arg Thr Leu Leu Thr Ser Leu Thr Ser 
        355                 360                 365             


Glu Asn Asn Thr Ile Ala Leu Val Thr Val Asp Leu Gly Gln Arg Asn 
    370                 375                 380                 


Pro Ala Ala Ile Met Ile Ser Arg Leu Ser Arg Lys Glu Glu Leu Ser 
385                 390                 395                 400 


Glu Lys Asp Ile Gln Pro Val Ser Arg Arg Leu Leu Pro Asp Arg Tyr 
                405                 410                 415     


Leu Asn Glu Leu Lys Arg Tyr Arg Asp Ala Tyr Asp Ala Phe Arg Gln 
            420                 425                 430         


Glu Val Arg Asp Glu Ala Phe Thr Ser Leu Cys Pro Glu His Gln Glu 
        435                 440                 445             


Gln Val Gln Gln Tyr Glu Ala Leu Thr Pro Glu Lys Ala Lys Asn Leu 
    450                 455                 460                 


Val Leu Lys His Phe Phe Gly Thr His Asp Pro Asp Leu Pro Trp Asp 
465                 470                 475                 480 


Asp Met Thr Ser Asn Thr His Tyr Ile Ala Asn Leu Tyr Leu Glu Arg 
                485                 490                 495     


Gly Gly Asp Pro Ser Lys Val Phe Phe Thr Arg Pro Leu Lys Lys Asp 
            500                 505                 510         


Ser Lys Ser Lys Lys Pro Arg Lys Pro Thr Lys Arg Thr Asp Ala Ser 
        515                 520                 525             


Ile Ser Arg Leu Pro Glu Ile Arg Pro Lys Met Pro Glu Asp Ala Arg 
    530                 535                 540                 


Lys Ala Phe Glu Lys Ala Lys Trp Glu Ile Tyr Thr Gly His Glu Lys 
545                 550                 555                 560 


Phe Pro Lys Leu Ala Lys Arg Val Asn Gln Leu Cys Arg Glu Ile Ala 
                565                 570                 575     


Asn Trp Ile Glu Lys Glu Ala Lys Arg Leu Thr Leu Cys Asp Thr Val 
            580                 585                 590         


Val Val Gly Ile Glu Asp Leu Ser Leu Pro Pro Lys Arg Gly Lys Gly 
        595                 600                 605             


Lys Phe Gln Glu Thr Trp Gln Gly Phe Phe Arg Gln Lys Phe Glu Asn 
    610                 615                 620                 


Arg Trp Val Ile Asp Thr Leu Lys Lys Ala Ile Gln Asn Arg Ala His 
625                 630                 635                 640 


Asp Lys Gly Lys Tyr Val Leu Gly Leu Ala Pro Tyr Trp Thr Ser Gln 
                645                 650                 655     


Arg Cys Pro Ala Cys Gly Phe Ile His Lys Ser Asn Arg Asn Gly Asp 
            660                 665                 670         


His Phe Lys Cys Leu Lys Cys Glu Ala Leu Phe His Ala Asp Ser Glu 
        675                 680                 685             


Val Ala Thr Trp Asn Leu Ala Leu Val Ala Val Leu Gly Lys Gly Ile 
    690                 695                 700                 


Thr Asn Pro Asp Ser Lys Lys Pro Ser Gly Gln Lys Lys Thr Gly Thr 
705                 710                 715                 720 


Thr Arg Lys Lys Gln Ile Lys Gly Lys Asn Lys Gly Lys Glu Thr Val 
                725                 730                 735     


Asn Val Pro Pro Thr Thr Gln Glu Val Glu Asp Ile Ile Ala Phe Phe 
            740                 745                 750         


Glu Lys Asp Asp Glu Thr Val Arg Asn Pro Val Tyr Lys Pro Thr Gly 
        755                 760                 765             


Thr 
    


<210> 180
<211> 767
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 180
Val Ile Lys Thr His Phe Pro Ala Gly Arg Phe Arg Lys Asp His Gln 
1               5                   10                  15      


Lys Thr Ala Gly Lys Lys Leu Lys His Glu Gly Glu Glu Ala Cys Val 
            20                  25                  30          


Glu Tyr Leu Arg Asn Lys Val Ser Asp Tyr Pro Pro Asn Phe Lys Pro 
        35                  40                  45              


Pro Ala Lys Gly Thr Ile Val Ala Gln Ser Arg Pro Phe Ser Glu Trp 
    50                  55                  60                  


Pro Ile Val Arg Ala Ser Glu Ala Ile Gln Lys Tyr Val Tyr Gly Leu 
65                  70                  75                  80  


Thr Val Ala Glu Leu Asp Val Phe Ser Pro Gly Thr Ser Lys Pro Ser 
                85                  90                  95      


His Ala Glu Trp Phe Ala Lys Thr Gly Val Glu Asn Tyr Gly Tyr Arg 
            100                 105                 110         


Gln Val Gln Gly Leu Asn Thr Ile Phe Gln Asn Thr Val Asn Arg Phe 
        115                 120                 125             


Lys Gly Val Leu Lys Lys Val Glu Asn Arg Asn Lys Lys Ser Leu Lys 
    130                 135                 140                 


Arg Gln Glu Gly Ala Asn Arg Arg Arg Val Glu Glu Gly Leu Pro Glu 
145                 150                 155                 160 


Val Pro Val Thr Val Glu Ser Ala Thr Asp Asp Glu Gly Arg Leu Leu 
                165                 170                 175     


Gln Pro Pro Gly Val Asn Pro Ser Ile Tyr Gly Tyr Gln Gly Val Ala 
            180                 185                 190         


Pro Arg Val Cys Thr Asp Leu Gln Gly Phe Ser Gly Met Ser Val Asp 
        195                 200                 205             


Phe Ala Gly Tyr Arg Arg Asp Pro Asp Ala Val Leu Val Glu Ser Leu 
    210                 215                 220                 


Pro Glu Gly Arg Leu Ser Ile Pro Lys Gly Glu Arg Gly Tyr Val Pro 
225                 230                 235                 240 


Glu Trp Gln Arg Asp Pro Glu Arg Asn Lys Phe Pro Leu Arg Glu Gly 
                245                 250                 255     


Ser Arg Arg Gln Arg Lys Trp Tyr Ser Asn Ala Cys His Lys Pro Lys 
            260                 265                 270         


Pro Gly Arg Thr Ser Lys Tyr Asp Pro Glu Ala Leu Lys Lys Ala Ser 
        275                 280                 285             


Ala Lys Asp Ala Leu Leu Val Ser Ile Ser Ile Gly Glu Asp Trp Ala 
    290                 295                 300                 


Ile Ile Asp Val Arg Gly Leu Leu Arg Asp Ala Arg Arg Arg Gly Phe 
305                 310                 315                 320 


Thr Pro Glu Glu Gly Leu Ser Leu Asn Ser Leu Leu Gly Leu Phe Thr 
                325                 330                 335     


Glu Tyr Pro Val Phe Asp Val Gln Arg Gly Leu Ile Thr Phe Thr Tyr 
            340                 345                 350         


Lys Leu Gly Gln Val Asp Val His Ser Arg Lys Thr Val Pro Thr Phe 
        355                 360                 365             


Arg Ser Arg Ala Leu Leu Glu Ser Leu Val Ala Lys Glu Glu Ile Ala 
    370                 375                 380                 


Leu Val Ser Val Asp Leu Gly Gln Thr Asn Pro Ala Ser Met Lys Val 
385                 390                 395                 400 


Ser Arg Val Arg Ala Gln Glu Gly Ala Leu Val Ala Glu Pro Val His 
                405                 410                 415     


Arg Met Phe Leu Ser Asp Val Leu Leu Gly Glu Leu Ser Ser Tyr Arg 
            420                 425                 430         


Lys Arg Met Asp Ala Phe Glu Asp Ala Ile Arg Ala Gln Ala Phe Glu 
        435                 440                 445             


Thr Met Thr Pro Glu Gln Gln Ala Glu Ile Thr Arg Val Cys Asp Val 
    450                 455                 460                 


Ser Val Glu Val Ala Arg Arg Arg Val Cys Glu Lys Tyr Ser Ile Ser 
465                 470                 475                 480 


Pro Gln Asp Val Pro Trp Gly Glu Met Thr Gly His Ser Thr Phe Ile 
                485                 490                 495     


Val Asp Ala Val Leu Arg Lys Gly Gly Asp Glu Ser Leu Val Tyr Phe 
            500                 505                 510         


Lys Asn Lys Glu Gly Glu Thr Leu Lys Phe Arg Asp Leu Arg Ile Ser 
        515                 520                 525             


Arg Met Glu Gly Val Arg Pro Arg Leu Thr Lys Asp Thr Arg Asp Ala 
    530                 535                 540                 


Leu Asn Lys Ala Val Leu Asp Leu Lys Arg Ala His Pro Thr Phe Ala 
545                 550                 555                 560 


Lys Leu Ala Lys Gln Lys Leu Glu Leu Ala Arg Arg Cys Val Asn Phe 
                565                 570                 575     


Ile Glu Arg Glu Ala Lys Arg Tyr Thr Gln Cys Glu Arg Val Val Phe 
            580                 585                 590         


Val Ile Glu Asp Leu Asn Val Gly Phe Phe His Gly Lys Gly Lys Arg 
        595                 600                 605             


Asp Arg Gly Trp Asp Ala Phe Phe Thr Ala Lys Lys Glu Asn Arg Trp 
    610                 615                 620                 


Val Ile Gln Ala Leu His Lys Ala Phe Ser Asp Leu Gly Leu His Arg 
625                 630                 635                 640 


Gly Ser Tyr Val Ile Glu Val Thr Pro Gln Arg Thr Ser Met Thr Cys 
                645                 650                 655     


Pro Arg Cys Gly His Cys Asp Lys Gly Asn Arg Asn Gly Glu Lys Phe 
            660                 665                 670         


Val Cys Leu Gln Cys Gly Ala Thr Leu His Ala Asp Leu Glu Val Ala 
        675                 680                 685             


Thr Asp Asn Ile Glu Arg Val Ala Leu Thr Gly Lys Ala Met Pro Lys 
    690                 695                 700                 


Pro Pro Val Arg Glu Arg Ser Gly Asp Val Gln Lys Ala Gly Thr Ala 
705                 710                 715                 720 


Arg Lys Ala Arg Lys Pro Leu Lys Pro Lys Gln Lys Thr Glu Pro Ser 
                725                 730                 735     


Val Gln Glu Gly Ser Ser Asp Asp Gly Val Asp Lys Ser Pro Gly Asp 
            740                 745                 750         


Ala Ser Arg Asn Pro Val Tyr Asn Pro Ser Asp Thr Leu Ser Ile 
        755                 760                 765         


<210> 181
<211> 763
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 181
Met Ala Lys Ala Lys Thr Leu Ala Ala Leu Leu Arg Glu Leu Leu Pro 
1               5                   10                  15      


Gly Gln His Leu Ala Pro His His Arg Trp Val Ala Asn Lys Leu Leu 
            20                  25                  30          


Met Thr Ser Gly Asp Ala Ala Ala Phe Val Ile Gly Lys Ser Val Ser 
        35                  40                  45              


Asp Pro Val Arg Gly Ser Phe Arg Lys Asp Val Ile Thr Lys Ala Gly 
    50                  55                  60                  


Arg Ile Phe Lys Lys Asp Gly Pro Asp Ala Ala Ala Ala Phe Leu Asp 
65                  70                  75                  80  


Gly Lys Trp Glu Asp Arg Pro Pro Asn Phe Gln Pro Pro Ala Lys Ala 
                85                  90                  95      


Ala Ile Val Ala Ile Ser Arg Ser Phe Asp Glu Trp Pro Ile Val Lys 
            100                 105                 110         


Val Ser Cys Ala Ile Gln Gln Tyr Leu Tyr Ala Leu Pro Val Gln Glu 
        115                 120                 125             


Phe Glu Ser Ser Val Pro Glu Ala Arg Ala Gln Ala His Ala Ala Trp 
    130                 135                 140                 


Phe Gln Asp Thr Gly Val Asp Asp Cys Asn Phe Lys Ser Thr Gln Gly 
145                 150                 155                 160 


Leu Asn Ala Ile Phe Asn His Gly Lys Arg Thr Tyr Glu Gly Val Leu 
                165                 170                 175     


Lys Lys Ala Gln Asn Arg Asn Asp Lys Lys Asn Leu Arg Leu Glu Arg 
            180                 185                 190         


Ile Asn Ala Lys Arg Ala Glu Ala Gly Gln Ala Pro Leu Val Ala Gly 
        195                 200                 205             


Pro Asp Glu Ser Pro Thr Asp Asp Ala Gly Cys Leu Leu His Pro Pro 
    210                 215                 220                 


Gly Ile Asn Ala Asn Ile Tyr Cys Tyr Gln Gln Val Ser Pro Arg Pro 
225                 230                 235                 240 


Tyr Glu Gln Ser Cys Gly Ile Gln Leu Pro Pro Glu Tyr Ala Gly Tyr 
                245                 250                 255     


Asn Arg Leu Ser Asn Val Ala Ile Pro Pro Met Pro Asn Arg Leu Asp 
            260                 265                 270         


Ile Pro Gln Gly Gln Pro Gly Tyr Val Pro Glu His His Arg His Gly 
        275                 280                 285             


Ile Lys Lys Phe Gly Arg Val Arg Lys Arg Tyr Gly Val Val Pro Gly 
    290                 295                 300                 


Arg Asn Arg Asp Ala Asp Gly Lys Arg Thr Arg Gln Val Leu Thr Glu 
305                 310                 315                 320 


Ala Gly Ala Ala Ala Lys Ala Arg Asp Ser Val Leu Ala Val Ile Arg 
                325                 330                 335     


Ile Gly Asp Asp Trp Thr Val Val Asp Leu Arg Gly Leu Leu Arg Asn 
            340                 345                 350         


Ala Gln Trp Arg Lys Leu Val Pro Asp Gly Gly Ile Thr Val Gln Gly 
        355                 360                 365             


Leu Leu Asp Leu Phe Thr Gly Asp Pro Val Ile Asp Pro Arg Arg Gly 
    370                 375                 380                 


Val Val Thr Phe Ile Tyr Lys Ala Asp Ser Val Gly Ile His Ser Glu 
385                 390                 395                 400 


Lys Val Cys Arg Gly Lys Gln Ser Lys Asn Leu Leu Glu Arg Leu Cys 
                405                 410                 415     


Ala Met Pro Glu Lys Ser Ser Thr Arg Leu Asp Cys Ala Arg Gln Ala 
            420                 425                 430         


Val Ala Leu Val Ser Val Asp Leu Gly Gln Arg Asn Pro Val Ala Ala 
        435                 440                 445             


Arg Phe Ser Arg Val Ser Leu Ala Glu Gly Gln Leu Gln Ala Gln Leu 
    450                 455                 460                 


Val Ser Ala Gln Phe Leu Asp Asp Ala Met Val Ala Met Ile Arg Ser 
465                 470                 475                 480 


Tyr Arg Glu Glu Tyr Asp Arg Phe Glu Ser Leu Val Arg Glu Gln Ala 
                485                 490                 495     


Lys Ala Ala Leu Ser Pro Glu Gln Leu Ser Glu Ile Val Arg His Glu 
            500                 505                 510         


Ala Asp Ser Ala Glu Ser Val Lys Ser Cys Val Cys Ala Lys Phe Gly 
        515                 520                 525             


Ile Asp Pro Ala Gly Leu Ser Trp Asp Lys Met Thr Ser Gly Thr Trp 
    530                 535                 540                 


Arg Ile Ala Asp His Val Gln Ala Ala Gly Gly Asp Val Glu Trp Phe 
545                 550                 555                 560 


Phe Phe Lys Thr Cys Gly Lys Gly Lys Glu Ile Lys Thr Val Arg Arg 
                565                 570                 575     


Ser Asp Phe Asn Val Ala Lys Gln Phe Arg Leu Arg Leu Ser Pro Glu 
            580                 585                 590         


Thr Arg Lys Asp Trp Asn Asp Ala Ile Trp Glu Leu Lys Arg Gly Asn 
        595                 600                 605             


Pro Ala Tyr Val Ser Phe Ser Lys Arg Lys Ser Glu Phe Ala Arg Arg 
    610                 615                 620                 


Val Val Asn Asp Leu Val His Arg Ala Arg Arg Ala Val Arg Cys Asp 
625                 630                 635                 640 


Glu Val Val Phe Ala Ile Glu Asp Leu Asn Ile Ser Phe Phe His Gly 
                645                 650                 655     


Lys Gly Gln Arg Gln Met Gly Trp Asp Ala Phe Phe Glu Val Lys Gln 
            660                 665                 670         


Glu Asn Arg Trp Phe Ile Gln Ala Leu His Lys Ala Phe Val Glu Arg 
        675                 680                 685             


Ala Thr His Lys Gly Gly Tyr Val Leu Glu Val Ala Pro Ala Arg Thr 
    690                 695                 700                 


Ser Thr Thr Cys Pro Glu Cys Arg His Cys Asp Pro Glu Ser Arg Arg 
705                 710                 715                 720 


Gly Glu Gln Phe Cys Cys Ile Lys Cys Arg His Thr Cys His Ala Asp 
                725                 730                 735     


Leu Glu Val Ala Thr Phe Asn Ile Glu Gln Val Ala Leu Thr Gly Val 
            740                 745                 750         


Ser Leu Pro Lys Arg Leu Ser Ser Thr Leu Leu 
        755                 760             


<210> 182
<211> 761
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 182
Met Ser Lys Glu Lys Thr Pro Pro Ser Ala Tyr Ala Ile Leu Lys Ala 
1               5                   10                  15      


Lys His Phe Pro Asp Leu Asp Phe Glu Lys Lys His Lys Met Met Ala 
            20                  25                  30          


Gly Arg Met Phe Lys Asn Gly Ala Ser Glu Gln Glu Val Val Gln Tyr 
        35                  40                  45              


Leu Gln Gly Lys Gly Ser Glu Ser Leu Met Asp Val Lys Pro Pro Ala 
    50                  55                  60                  


Lys Ser Pro Ile Leu Ala Gln Ser Arg Pro Phe Asp Glu Trp Glu Met 
65                  70                  75                  80  


Val Arg Thr Ser Arg Leu Ile Gln Glu Thr Ile Phe Gly Ile Pro Lys 
                85                  90                  95      


Arg Gly Ser Ile Pro Lys Arg Asp Gly Leu Ser Glu Thr Gln Phe Asn 
            100                 105                 110         


Glu Leu Val Ala Ser Leu Glu Val Gly Gly Lys Pro Met Leu Asn Lys 
        115                 120                 125             


Gln Thr Arg Ala Ile Phe Tyr Gly Leu Leu Gly Ile Lys Pro Pro Thr 
    130                 135                 140                 


Phe His Ala Met Ala Gln Asn Ile Leu Ile Asp Leu Ala Ile Asn Ile 
145                 150                 155                 160 


Arg Lys Gly Val Leu Lys Lys Val Asp Asn Leu Asn Glu Lys Asn Arg 
                165                 170                 175     


Lys Lys Val Lys Arg Ile Arg Asp Ala Gly Glu Gln Asp Val Met Val 
            180                 185                 190         


Pro Ala Glu Val Thr Ala His Asp Asp Arg Gly Tyr Leu Asn His Pro 
        195                 200                 205             


Pro Gly Val Asn Pro Thr Ile Pro Gly Tyr Gln Gly Val Val Ile Pro 
    210                 215                 220                 


Phe Pro Glu Gly Phe Glu Gly Leu Pro Ser Gly Met Thr Pro Val Asp 
225                 230                 235                 240 


Trp Ser His Val Leu Val Asp Tyr Leu Pro His Asp Arg Leu Ser Ile 
                245                 250                 255     


Pro Lys Gly Ser Pro Gly Tyr Ile Pro Glu Trp Gln Arg Pro Leu Leu 
            260                 265                 270         


Asn Arg His Lys Gly Arg Arg His Arg Ser Trp Tyr Ala Asn Ser Leu 
        275                 280                 285             


Asn Lys Pro Arg Lys Ser Arg Thr Glu Glu Ala Lys Asp Arg Gln Asn 
    290                 295                 300                 


Ala Gly Lys Arg Thr Ala Leu Ile Glu Ala Glu Arg Leu Lys Gly Val 
305                 310                 315                 320 


Leu Pro Val Leu Met Arg Phe Lys Glu Asp Trp Leu Ile Ile Asp Ala 
                325                 330                 335     


Arg Gly Leu Leu Arg Asn Ala Arg Tyr Arg Gly Val Leu Pro Glu Gly 
            340                 345                 350         


Ser Thr Leu Gly Asn Leu Ile Asp Leu Phe Ser Asp Ser Pro Arg Val 
        355                 360                 365             


Asp Thr Arg Arg Gly Ile Cys Thr Phe Leu Tyr Arg Lys Gly Arg Ala 
    370                 375                 380                 


Tyr Ser Thr Lys Pro Val Lys Arg Lys Glu Ser Lys Glu Thr Leu Leu 
385                 390                 395                 400 


Lys Leu Thr Glu Lys Ser Thr Ile Ala Leu Val Ser Ile Asp Leu Gly 
                405                 410                 415     


Gln Thr Asn Pro Leu Thr Ala Lys Leu Ser Lys Val Arg Gln Val Asp 
            420                 425                 430         


Gly Cys Leu Val Ala Glu Pro Val Leu Arg Lys Leu Ile Asp Asn Ala 
        435                 440                 445             


Ser Glu Asp Gly Lys Glu Ile Ala Arg Tyr Arg Val Ala His Asp Leu 
    450                 455                 460                 


Leu Arg Ala Arg Ile Leu Glu Asp Ala Ile Asp Leu Leu Gly Ile Tyr 
465                 470                 475                 480 


Lys Asp Glu Val Val Arg Ala Arg Ser Asp Thr Pro Asp Leu Cys Lys 
                485                 490                 495     


Glu Arg Val Cys Arg Phe Leu Gly Leu Asp Ser Gln Ala Ile Asp Trp 
            500                 505                 510         


Asp Arg Met Thr Pro Tyr Thr Asp Phe Ile Ala Gln Ala Phe Val Ala 
        515                 520                 525             


Lys Gly Gly Asp Pro Lys Val Val Thr Ile Lys Pro Asn Gly Lys Pro 
    530                 535                 540                 


Lys Met Phe Arg Lys Asp Arg Ser Ile Lys Asn Met Lys Gly Ile Arg 
545                 550                 555                 560 


Leu Asp Ile Ser Lys Glu Ala Ser Ser Ala Tyr Arg Glu Ala Gln Trp 
                565                 570                 575     


Ala Ile Gln Arg Glu Ser Pro Asp Phe Gln Arg Leu Ala Val Trp Gln 
            580                 585                 590         


Ser Gln Leu Thr Lys Arg Ile Val Asn Gln Leu Val Ala Trp Ala Lys 
        595                 600                 605             


Lys Cys Thr Gln Cys Asp Thr Val Val Leu Ala Phe Glu Asp Leu Asn 
    610                 615                 620                 


Ile Gly Met Met His Gly Ser Gly Lys Trp Ala Asn Gly Gly Trp Asn 
625                 630                 635                 640 


Ala Leu Phe Leu His Lys Gln Glu Asn Arg Trp Phe Met Gln Ala Phe 
                645                 650                 655     


His Lys Ala Leu Thr Glu Leu Ser Ala His Lys Gly Ile Pro Thr Ile 
            660                 665                 670         


Glu Val Leu Pro His Arg Thr Ser Ile Thr Cys Thr Gln Cys Gly His 
        675                 680                 685             


Cys His Pro Gly Asn Arg Asp Gly Glu Arg Phe Lys Cys Leu Lys Cys 
    690                 695                 700                 


Glu Phe Leu Ala Asn Thr Asp Leu Glu Ile Ala Thr Asp Asn Ile Glu 
705                 710                 715                 720 


Arg Val Ala Leu Thr Gly Leu Pro Met Pro Lys Gly Glu Arg Ser Ser 
                725                 730                 735     


Ala Lys Arg Lys Pro Gly Gly Thr Arg Lys Thr Lys Lys Ser Lys His 
            740                 745                 750         


Ser Gly Asn Ser Pro Leu Ala Ala Glu 
        755                 760     


<210> 183
<211> 746
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 183
Met Glu Lys Ala Gly Pro Thr Ser Pro Leu Ser Val Leu Ile His Lys 
1               5                   10                  15      


Asn Phe Glu Gly Cys Arg Phe Gln Ile Asp His Leu Lys Ile Ala Gly 
            20                  25                  30          


Arg Lys Leu Ala Arg Glu Gly Glu Ala Ala Ala Ile Glu Tyr Leu Leu 
        35                  40                  45              


Asp Lys Lys Cys Glu Gly Leu Pro Pro Asn Phe Gln Pro Pro Ala Lys 
    50                  55                  60                  


Gly Asn Val Ile Ala Gln Ser Arg Pro Phe Thr Glu Trp Ala Pro Tyr 
65                  70                  75                  80  


Arg Ala Ser Val Ala Ile Gln Lys Tyr Ile Tyr Ser Leu Ser Val Asp 
                85                  90                  95      


Glu Arg Lys Val Cys Asp Pro Gly Ser Ser Ser Asp Ser His Glu Lys 
            100                 105                 110         


Trp Phe Lys Gln Thr Gly Val Gln Asn Tyr Gly Tyr Thr His Val Gln 
        115                 120                 125             


Gly Leu Asn Leu Ile Phe Lys His Ala Leu Ala Arg Tyr Asp Gly Val 
    130                 135                 140                 


Leu Lys Lys Val Asp Asn Arg Asn Glu Lys Asn Arg Lys Lys Ala Glu 
145                 150                 155                 160 


Arg Val Asn Ser Phe Arg Arg Glu Glu Gly Leu Pro Glu Glu Val Phe 
                165                 170                 175     


Glu Glu Glu Lys Ala Thr Asp Glu Thr Gly His Leu Leu Gln Pro Pro 
            180                 185                 190         


Gly Val Asn His Ser Ile Tyr Cys Tyr Gln Ser Val Arg Pro Lys Pro 
        195                 200                 205             


Phe Asn Pro Arg Lys Pro Gly Gly Ile Ser Leu Pro Glu Ala Tyr Ser 
    210                 215                 220                 


Gly Tyr Ser Leu Lys Pro Gln Asp Glu Leu Pro Ile Gly Ser Leu Asp 
225                 230                 235                 240 


Arg Leu Ser Ile Pro Pro Gly Gln Pro Gly Tyr Val Pro Glu Trp Gln 
                245                 250                 255     


Arg Ser Gln Leu Thr Thr Gln Lys His Arg Arg Lys Arg Ser Trp Tyr 
            260                 265                 270         


Ser Ala Gln Lys Trp Lys Pro Arg Thr Gly Arg Thr Ser Thr Phe Asp 
        275                 280                 285             


Pro Asp Arg Leu Asn Cys Ala Arg Ala Gln Gly Ala Ile Leu Ala Val 
    290                 295                 300                 


Val Arg Ile His Glu Asp Trp Val Val Phe Asp Val Arg Gly Leu Leu 
305                 310                 315                 320 


Arg Asn Ala Leu Trp Arg Glu Leu Ala Gly Lys Gly Leu Thr Val Arg 
                325                 330                 335     


Asp Leu Leu Asp Phe Phe Thr Gly Asp Pro Val Val Asp Thr Lys Arg 
            340                 345                 350         


Gly Val Val Thr Phe Thr Tyr Lys Leu Gly Lys Val Asp Val His Ser 
        355                 360                 365             


Leu Arg Thr Val Arg Gly Lys Arg Ser Lys Lys Val Leu Glu Asp Leu 
    370                 375                 380                 


Thr Leu Ser Ser Asp Val Gly Leu Val Thr Ile Asp Leu Gly Gln Thr 
385                 390                 395                 400 


Asn Val Leu Ala Ala Asp Tyr Ser Lys Val Thr Arg Ser Glu Asn Gly 
                405                 410                 415     


Glu Leu Leu Ala Val Pro Leu Ser Lys Ser Phe Leu Pro Lys His Leu 
            420                 425                 430         


Leu His Glu Val Thr Ala Tyr Arg Thr Ser Tyr Asp Gln Met Glu Glu 
        435                 440                 445             


Gly Phe Arg Arg Lys Ala Leu Leu Thr Leu Thr Glu Asp Gln Gln Val 
    450                 455                 460                 


Glu Val Thr Leu Val Arg Asp Phe Ser Val Glu Ser Ser Lys Thr Lys 
465                 470                 475                 480 


Leu Leu Gln Leu Gly Val Asp Val Thr Ser Leu Pro Trp Glu Lys Met 
                485                 490                 495     


Ser Ser Asn Thr Thr Tyr Ile Ser Asp Gln Leu Leu Gln Gln Gly Ala 
            500                 505                 510         


Asp Pro Ala Ser Leu Phe Phe Asp Gly Glu Arg Asp Gly Lys Pro Cys 
        515                 520                 525             


Arg His Lys Lys Lys Asp Arg Thr Trp Ala Tyr Leu Val Arg Pro Lys 
    530                 535                 540                 


Val Ser Pro Glu Thr Arg Lys Ala Leu Asn Glu Ala Leu Trp Ala Leu 
545                 550                 555                 560 


Lys Asn Thr Ser Pro Glu Phe Glu Ser Leu Ser Lys Arg Lys Ile Gln 
                565                 570                 575     


Phe Ser Arg Arg Cys Met Asn Tyr Leu Leu Asn Glu Ala Lys Arg Ile 
            580                 585                 590         


Ser Gly Cys Gly Gln Val Val Phe Val Ile Glu Asp Leu Asn Val Arg 
        595                 600                 605             


Val His His Gly Arg Gly Lys Arg Ala Ile Gly Trp Asp Asn Phe Phe 
    610                 615                 620                 


Lys Pro Lys Arg Glu Asn Arg Trp Phe Met Gln Ala Leu His Lys Ala 
625                 630                 635                 640 


Ala Ser Glu Leu Ala Ile His Arg Gly Met His Ile Ile Glu Ala Cys 
                645                 650                 655     


Pro Ala Arg Ser Ser Ile Thr Cys Pro Lys Cys Gly His Cys Asp Pro 
            660                 665                 670         


Glu Asn Arg Cys Ser Ser Asp Arg Glu Lys Phe Leu Cys Val Lys Cys 
        675                 680                 685             


Gly Ala Ala Phe His Ala Asp Leu Glu Val Ala Thr Phe Asn Leu Arg 
    690                 695                 700                 


Lys Val Ala Leu Thr Gly Thr Ala Leu Pro Lys Ser Ile Asp His Ser 
705                 710                 715                 720 


Arg Asp Gly Leu Ile Pro Lys Gly Ala Arg Asn Arg Lys Leu Lys Glu 
                725                 730                 735     


Pro Gln Ala Asn Asp Glu Lys Ala Cys Ala 
            740                 745     


<210> 184
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 184
Met Lys Glu Gln Ser Pro Leu Ser Ser Val Leu Lys Ser Asn Phe Pro 
1               5                   10                  15      


Gly Lys Lys Phe Leu Ser Ala Asp Ile Arg Val Ala Gly Arg Lys Leu 
            20                  25                  30          


Ala Gln Leu Gly Glu Ala Ala Ala Val Glu Tyr Leu Ser Pro Arg Gln 
        35                  40                  45              


Arg Asp Ser Val Pro Asn Phe Arg Pro Pro Ala Phe Cys Thr Val Val 
    50                  55                  60                  


Ala Lys Ser Arg Pro Phe Glu Glu Trp Pro Ile Tyr Lys Ala Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Gln Ile Tyr Gly Met Thr Gly Gln Glu Phe Glu Glu 
                85                  90                  95      


Arg Cys Gly Ser Ile Pro Thr Ser Leu Ser Gly Leu Arg Gln Trp Ala 
            100                 105                 110         


Ser Ser Val Gly Leu Gly Ala Ala Met Glu Gly Leu His Val Gln Gly 
        115                 120                 125             


Met Asn Leu Met Val Lys Asn Ala Ile Asn Arg Tyr Lys Gly Val Leu 
    130                 135                 140                 


Val Lys Val Glu Asn Arg Asn Lys Lys Leu Val Glu Ala Asn Glu Ala 
145                 150                 155                 160 


Lys Asn Ser Ser Arg Glu Glu Arg Gly Leu Pro Pro Leu Arg Pro Pro 
                165                 170                 175     


Glu Leu Gly Ser Ala Phe Gly Pro Asp Gly Arg Leu Val Asn Pro Pro 
            180                 185                 190         


Gly Ile Asp Lys Ser Ile Arg Leu Tyr Gln Gly Val Ser Pro Val Pro 
        195                 200                 205             


Val Val Lys Thr Thr Gly Arg Pro Thr Val His Arg Leu Asp Ile Pro 
    210                 215                 220                 


Ala Gly Glu Lys Gly His Val Pro Leu Trp Gln Arg Glu Ala Gly Leu 
225                 230                 235                 240 


Val Lys Glu Gly Pro Arg Arg Arg Arg Met Trp Tyr Ser Asn Ser Asn 
                245                 250                 255     


Leu Lys Arg Ser Arg Lys Asp Arg Ser Ala Glu Ala Ser Glu Ala Arg 
            260                 265                 270         


Lys Ala Asp Ser Val Val Val Arg Val Ser Val Lys Glu Asp Trp Val 
        275                 280                 285             


Asp Ile Asp Val Arg Gly Leu Leu Arg Asn Val Ala Trp Arg Gly Ile 
    290                 295                 300                 


Glu Arg Ala Gly Glu Ser Thr Glu Asp Leu Leu Ser Leu Phe Ser Gly 
305                 310                 315                 320 


Asp Pro Val Val Asp Pro Ser Arg Asp Ser Val Val Phe Leu Tyr Lys 
                325                 330                 335     


Glu Gly Val Val Asp Val Leu Ser Lys Lys Val Val Gly Ala Gly Lys 
            340                 345                 350         


Ser Arg Lys Gln Leu Glu Lys Met Val Ser Glu Gly Pro Val Ala Leu 
        355                 360                 365             


Val Ser Cys Asp Leu Gly Gln Thr Asn Tyr Val Ala Ala Arg Val Ser 
    370                 375                 380                 


Val Leu Asp Glu Ser Leu Ser Pro Val Arg Ser Phe Arg Val Asp Pro 
385                 390                 395                 400 


Arg Glu Phe Pro Ser Ala Asp Gly Ser Gln Gly Val Val Gly Ser Leu 
                405                 410                 415     


Asp Arg Ile Arg Ala Asp Ser Asp Arg Leu Glu Ala Lys Leu Leu Ser 
            420                 425                 430         


Glu Ala Glu Ala Ser Leu Pro Glu Pro Val Arg Ala Glu Ile Glu Phe 
        435                 440                 445             


Leu Arg Ser Glu Arg Pro Ser Ala Val Ala Gly Arg Leu Cys Leu Lys 
    450                 455                 460                 


Leu Gly Ile Asp Pro Arg Ser Ile Pro Trp Glu Lys Met Gly Ser Thr 
465                 470                 475                 480 


Thr Ser Phe Ile Ser Glu Ala Leu Ser Ala Lys Gly Ser Pro Leu Ala 
                485                 490                 495     


Leu His Asp Gly Ala Pro Ile Lys Asp Ser Arg Phe Ala His Ala Ala 
            500                 505                 510         


Arg Gly Arg Leu Ser Pro Glu Ser Arg Lys Ala Leu Asn Glu Ala Leu 
        515                 520                 525             


Trp Glu Arg Lys Ser Ser Ser Arg Glu Tyr Gly Val Ile Ser Arg Arg 
    530                 535                 540                 


Lys Ser Glu Ala Ser Arg Arg Met Ala Asn Ala Val Leu Ser Glu Ser 
545                 550                 555                 560 


Arg Arg Leu Thr Gly Leu Ala Val Val Ala Val Asn Leu Glu Asp Leu 
                565                 570                 575     


Asn Met Val Ser Lys Phe Phe His Gly Arg Gly Lys Arg Ala Pro Gly 
            580                 585                 590         


Trp Ala Gly Phe Phe Thr Pro Lys Met Glu Asn Arg Trp Phe Ile Arg 
        595                 600                 605             


Ser Ile His Lys Ala Met Cys Asp Leu Ser Lys His Arg Gly Ile Thr 
    610                 615                 620                 


Val Ile Glu Ser Arg Pro Glu Arg Thr Ser Ile Ser Cys Pro Glu Cys 
625                 630                 635                 640 


Gly His Cys Asp Pro Glu Asn Arg Ser Gly Glu Arg Phe Ser Cys Lys 
                645                 650                 655     


Ser Cys Gly Val Ser Leu His Ala Asp Phe Glu Val Ala Thr Arg Asn 
            660                 665                 670         


Leu Glu Arg Val Ala Leu Thr Gly Lys Pro Met Pro Arg Arg Glu Asn 
        675                 680                 685             


Leu His Ser Pro Glu Gly Ala Thr Ala Ser Arg Lys Thr Arg Lys Lys 
    690                 695                 700                 


Pro Arg Glu Ala Thr Ala Ser Thr Phe Leu Asp Leu Arg Ser Val Leu 
705                 710                 715                 720 


Ser Ser Ala Glu Asn Glu Gly Ser Gly Pro Ala Ala Arg Ala Gly 
                725                 730                 735 


<210> 185
<211> 725
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 185
Met Leu Pro Pro Ser Asn Lys Ile Gly Lys Ser Met Ser Leu Lys Glu 
1               5                   10                  15      


Phe Ile Asn Lys Arg Asn Phe Lys Ser Ser Ile Ile Lys Gln Ala Gly 
            20                  25                  30          


Lys Ile Leu Lys Lys Glu Gly Glu Glu Ala Val Lys Lys Tyr Leu Asp 
        35                  40                  45              


Asp Asn Tyr Val Glu Gly Tyr Lys Lys Arg Asp Phe Pro Ile Thr Ala 
    50                  55                  60                  


Lys Cys Asn Ile Val Ala Ser Asn Arg Lys Ile Glu Asp Phe Asp Ile 
65                  70                  75                  80  


Ser Lys Phe Ser Ser Phe Ile Gln Asn Tyr Val Phe Asn Leu Asn Lys 
                85                  90                  95      


Asp Asn Phe Glu Glu Phe Ser Lys Ile Lys Tyr Asn Arg Lys Ser Phe 
            100                 105                 110         


Asp Glu Leu Tyr Lys Lys Ile Ala Asn Glu Ile Gly Leu Glu Lys Pro 
        115                 120                 125             


Asn Tyr Glu Asn Ile Gln Gly Glu Ile Ala Val Ile Arg Asn Ala Ile 
    130                 135                 140                 


Asn Ile Tyr Asn Gly Val Leu Lys Lys Val Glu Asn Arg Asn Lys Lys 
145                 150                 155                 160 


Ile Gln Glu Lys Asn Gln Ser Lys Asp Pro Pro Lys Leu Leu Ser Ala 
                165                 170                 175     


Phe Asp Asp Asn Gly Phe Leu Ala Glu Arg Pro Gly Ile Asn Glu Thr 
            180                 185                 190         


Ile Tyr Gly Tyr Gln Ser Val Arg Leu Arg His Leu Asp Val Glu Lys 
        195                 200                 205             


Asp Lys Asp Ile Ile Val Gln Leu Pro Asp Ile Tyr Gln Lys Tyr Asn 
    210                 215                 220                 


Lys Lys Ser Thr Asp Lys Ile Ser Val Lys Lys Arg Leu Asn Lys Tyr 
225                 230                 235                 240 


Asn Val Asp Glu Tyr Gly Lys Leu Ile Ser Lys Arg Arg Lys Glu Arg 
                245                 250                 255     


Ile Asn Lys Asp Asp Ala Ile Leu Cys Val Ser Asn Phe Gly Asp Asp 
            260                 265                 270         


Trp Ile Ile Phe Asp Ala Arg Gly Leu Leu Arg Gln Thr Tyr Arg Tyr 
        275                 280                 285             


Lys Leu Lys Lys Lys Gly Leu Cys Ile Lys Asp Leu Leu Asn Leu Phe 
    290                 295                 300                 


Thr Gly Asp Pro Ile Ile Asn Pro Thr Lys Thr Asp Leu Lys Glu Ala 
305                 310                 315                 320 


Leu Ser Leu Ser Phe Lys Asp Gly Ile Ile Asn Asn Arg Thr Leu Lys 
                325                 330                 335     


Val Lys Asn Tyr Lys Lys Cys Pro Glu Leu Ile Ser Glu Leu Ile Arg 
            340                 345                 350         


Asp Lys Gly Lys Val Ala Met Ile Ser Ile Asp Leu Gly Gln Thr Asn 
        355                 360                 365             


Pro Ile Ser Tyr Arg Leu Ser Lys Phe Thr Ala Asn Asn Val Ala Tyr 
    370                 375                 380                 


Ile Glu Asn Gly Val Ile Ser Glu Asp Asp Ile Val Lys Met Lys Lys 
385                 390                 395                 400 


Trp Arg Glu Lys Ser Asp Lys Leu Glu Asn Leu Ile Lys Glu Glu Ala 
                405                 410                 415     


Ile Ala Ser Leu Ser Asp Asp Glu Gln Arg Glu Val Arg Leu Tyr Glu 
            420                 425                 430         


Asn Asp Ile Ala Asp Asn Thr Lys Lys Lys Ile Leu Glu Lys Phe Asn 
        435                 440                 445             


Ile Arg Glu Glu Asp Leu Asp Phe Ser Lys Met Ser Asn Asn Thr Tyr 
    450                 455                 460                 


Phe Ile Arg Asp Cys Leu Lys Asn Lys Asn Ile Asp Glu Ser Glu Phe 
465                 470                 475                 480 


Thr Phe Glu Lys Asn Gly Lys Lys Leu Asp Pro Thr Asp Ala Cys Phe 
                485                 490                 495     


Ala Arg Glu Tyr Lys Asn Lys Leu Ser Glu Leu Thr Arg Lys Lys Ile 
            500                 505                 510         


Asn Glu Lys Ile Trp Glu Ile Lys Lys Asn Ser Lys Glu Tyr His Lys 
        515                 520                 525             


Ile Ser Ile Tyr Lys Lys Glu Thr Ile Arg Tyr Ile Val Asn Lys Leu 
    530                 535                 540                 


Ile Lys Gln Ser Lys Glu Lys Ser Glu Cys Asp Asp Ile Ile Val Asn 
545                 550                 555                 560 


Ile Glu Lys Leu Gln Ile Gly Gly Asn Phe Phe Gly Gly Arg Gly Lys 
                565                 570                 575     


Arg Asp Pro Gly Trp Asn Asn Phe Phe Leu Pro Lys Glu Glu Asn Arg 
            580                 585                 590         


Trp Phe Ile Asn Ala Cys His Lys Ala Phe Ser Glu Leu Ala Pro His 
        595                 600                 605             


Lys Gly Ile Ile Val Ile Glu Ser Asp Pro Ala Tyr Thr Ser Gln Thr 
    610                 615                 620                 


Cys Pro Lys Cys Glu Asn Cys Asp Lys Glu Asn Arg Asn Gly Glu Lys 
625                 630                 635                 640 


Phe Lys Cys Lys Lys Cys Asn Tyr Glu Ala Asn Ala Asp Ile Asp Val 
                645                 650                 655     


Ala Thr Glu Asn Leu Glu Lys Ile Ala Lys Asn Gly Arg Arg Leu Ile 
            660                 665                 670         


Lys Asn Phe Asp Gln Leu Gly Glu Arg Leu Pro Gly Ala Glu Met Pro 
        675                 680                 685             


Gly Gly Ala Arg Lys Arg Lys Pro Ser Lys Ser Leu Pro Lys Asn Gly 
    690                 695                 700                 


Arg Gly Ala Gly Val Gly Ser Glu Pro Glu Leu Ile Asn Gln Ser Pro 
705                 710                 715                 720 


Ser Gln Val Ile Ala 
                725 


<210> 186
<211> 718
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 186
Val Pro Asp Lys Lys Glu Thr Pro Leu Val Ala Leu Cys Lys Lys Ser 
1               5                   10                  15      


Phe Pro Gly Leu Arg Phe Lys Lys His Asp Ser Arg Gln Ala Gly Arg 
            20                  25                  30          


Ile Leu Lys Ser Lys Gly Glu Gly Ala Ala Val Ala Phe Leu Glu Gly 
        35                  40                  45              


Lys Gly Gly Thr Thr Gln Pro Asn Phe Lys Pro Pro Val Lys Cys Asn 
    50                  55                  60                  


Ile Val Ala Met Ser Arg Pro Leu Glu Glu Trp Pro Ile Tyr Lys Ala 
65                  70                  75                  80  


Ser Val Val Ile Gln Lys Tyr Val Tyr Ala Gln Ser Tyr Glu Glu Phe 
                85                  90                  95      


Lys Ala Thr Asp Pro Gly Lys Ser Glu Ala Gly Leu Arg Ala Trp Leu 
            100                 105                 110         


Lys Ala Thr Arg Val Asp Thr Asp Gly Tyr Phe Asn Val Gln Gly Leu 
        115                 120                 125             


Asn Leu Ile Phe Gln Asn Ala Arg Ala Thr Tyr Glu Gly Val Leu Lys 
    130                 135                 140                 


Lys Val Glu Asn Arg Asn Ser Lys Lys Val Ala Lys Ile Glu Gln Arg 
145                 150                 155                 160 


Asn Glu His Arg Ala Glu Arg Gly Leu Pro Leu Leu Thr Leu Asp Glu 
                165                 170                 175     


Pro Glu Thr Ala Leu Asp Glu Thr Gly His Leu Arg His Arg Pro Gly 
            180                 185                 190         


Ile Asn Cys Ser Val Phe Gly Tyr Gln His Met Lys Leu Lys Pro Tyr 
        195                 200                 205             


Val Pro Gly Ser Ile Pro Gly Val Thr Gly Tyr Ser Arg Asp Pro Ser 
    210                 215                 220                 


Thr Pro Ile Ala Ala Cys Gly Val Asp Arg Leu Glu Ile Pro Glu Gly 
225                 230                 235                 240 


Gln Pro Gly Tyr Val Pro Pro Trp Asp Arg Glu Asn Leu Ser Val Lys 
                245                 250                 255     


Lys His Arg Arg Lys Arg Ala Ser Trp Ala Arg Ser Arg Gly Gly Ala 
            260                 265                 270         


Ile Asp Asp Asn Met Leu Leu Ala Val Val Arg Val Ala Asp Asp Trp 
        275                 280                 285             


Ala Leu Leu Asp Leu Arg Gly Leu Leu Arg Asn Thr Gln Tyr Arg Lys 
    290                 295                 300                 


Leu Leu Asp Arg Ser Val Pro Val Thr Ile Glu Ser Leu Leu Asn Leu 
305                 310                 315                 320 


Val Thr Asn Asp Pro Thr Leu Ser Val Val Lys Lys Pro Gly Lys Pro 
                325                 330                 335     


Val Arg Tyr Thr Ala Thr Leu Ile Tyr Lys Gln Gly Val Val Pro Val 
            340                 345                 350         


Val Lys Ala Lys Val Val Lys Gly Ser Tyr Val Ser Lys Met Leu Asp 
        355                 360                 365             


Asp Thr Thr Glu Thr Phe Ser Leu Val Gly Val Asp Leu Gly Val Asn 
    370                 375                 380                 


Asn Leu Ile Ala Ala Asn Ala Leu Arg Ile Arg Pro Gly Lys Cys Val 
385                 390                 395                 400 


Glu Arg Leu Gln Ala Phe Thr Leu Pro Glu Gln Thr Val Glu Asp Phe 
                405                 410                 415     


Phe Arg Phe Arg Lys Ala Tyr Asp Lys His Gln Glu Asn Leu Arg Leu 
            420                 425                 430         


Ala Ala Val Arg Ser Leu Thr Ala Glu Gln Gln Ala Glu Val Leu Ala 
        435                 440                 445             


Leu Asp Thr Phe Gly Pro Glu Gln Ala Lys Met Gln Val Cys Gly His 
    450                 455                 460                 


Leu Gly Leu Ser Val Asp Glu Val Pro Trp Asp Lys Val Asn Ser Arg 
465                 470                 475                 480 


Ser Ser Ile Leu Ser Asp Leu Ala Lys Glu Arg Gly Val Asp Asp Thr 
                485                 490                 495     


Leu Tyr Met Phe Pro Phe Phe Lys Gly Lys Gly Lys Lys Arg Lys Thr 
            500                 505                 510         


Glu Ile Arg Lys Arg Trp Asp Val Asn Trp Ala Gln His Phe Arg Pro 
        515                 520                 525             


Gln Leu Thr Ser Glu Thr Arg Lys Ala Leu Asn Glu Ala Lys Trp Glu 
    530                 535                 540                 


Ala Glu Arg Asn Ser Ser Lys Tyr His Gln Leu Ser Ile Arg Lys Lys 
545                 550                 555                 560 


Glu Leu Ser Arg His Cys Val Asn Tyr Val Ile Arg Thr Ala Glu Lys 
                565                 570                 575     


Arg Ala Gln Cys Gly Lys Val Ile Val Ala Val Glu Asp Leu His His 
            580                 585                 590         


Ser Phe Arg Arg Gly Gly Lys Gly Ser Arg Lys Ser Gly Trp Gly Gly 
        595                 600                 605             


Phe Phe Ala Ala Lys Gln Glu Gly Arg Trp Leu Met Asp Ala Leu Phe 
    610                 615                 620                 


Gly Ala Phe Cys Asp Leu Ala Val His Arg Gly Tyr Arg Val Ile Lys 
625                 630                 635                 640 


Val Asp Pro Tyr Asn Thr Ser Arg Thr Cys Pro Glu Cys Gly His Cys 
                645                 650                 655     


Asp Lys Ala Asn Arg Asp Arg Val Asn Arg Glu Ala Phe Ile Cys Val 
            660                 665                 670         


Cys Cys Gly Tyr Arg Gly Asn Ala Asp Ile Asp Val Ala Ala Tyr Asn 
        675                 680                 685             


Ile Ala Met Val Ala Ile Thr Gly Val Ser Leu Arg Lys Ala Ala Arg 
    690                 695                 700                 


Ala Ser Val Ala Ser Thr Pro Leu Glu Ser Leu Ala Ala Glu 
705                 710                 715             


<210> 187
<211> 708
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 187
Met Ser Lys Thr Lys Glu Leu Asn Asp Tyr Gln Glu Ala Leu Ala Arg 
1               5                   10                  15      


Arg Leu Pro Gly Val Arg His Gln Lys Ser Val Arg Arg Ala Ala Arg 
            20                  25                  30          


Leu Val Tyr Asp Arg Gln Gly Glu Asp Ala Met Val Ala Phe Leu Asp 
        35                  40                  45              


Gly Lys Glu Val Asp Glu Pro Tyr Thr Leu Gln Pro Pro Ala Lys Cys 
    50                  55                  60                  


His Ile Leu Ala Val Ser Arg Pro Ile Glu Glu Trp Pro Ile Ala Arg 
65                  70                  75                  80  


Val Thr Met Ala Val Gln Glu His Val Tyr Ala Leu Pro Val His Glu 
                85                  90                  95      


Val Glu Lys Ser Arg Pro Glu Thr Thr Glu Gly Ser Arg Ser Ala Trp 
            100                 105                 110         


Phe Lys Asn Ser Gly Val Ser Asn His Gly Val Thr His Ala Gln Thr 
        115                 120                 125             


Leu Asn Ala Ile Leu Lys Asn Ala Tyr Asn Val Tyr Asn Gly Val Ile 
    130                 135                 140                 


Lys Lys Val Glu Asn Arg Asn Ala Lys Lys Arg Asp Ser Leu Ala Ala 
145                 150                 155                 160 


Lys Asn Lys Ser Arg Glu Arg Lys Gly Leu Pro His Phe Lys Ala Asp 
                165                 170                 175     


Pro Pro Glu Leu Ala Thr Asp Glu Gln Gly Tyr Leu Leu Gln Pro Pro 
            180                 185                 190         


Ser Pro Asn Ser Ser Val Tyr Leu Val Gln Gln His Leu Arg Thr Pro 
        195                 200                 205             


Gln Ile Asp Leu Pro Ser Gly Tyr Thr Gly Pro Val Val Asp Pro Arg 
    210                 215                 220                 


Ser Pro Ile Pro Ser Leu Ile Pro Ile Asp Arg Leu Ala Ile Pro Pro 
225                 230                 235                 240 


Gly Gln Pro Gly Tyr Val Pro Leu His Asp Arg Glu Lys Leu Thr Ser 
                245                 250                 255     


Asn Lys His Arg Arg Met Lys Leu Pro Lys Ser Leu Arg Ala Gln Gly 
            260                 265                 270         


Ala Leu Pro Val Cys Phe Arg Val Phe Asp Asp Trp Ala Val Val Asp 
        275                 280                 285             


Gly Arg Gly Leu Leu Arg His Ala Gln Tyr Arg Arg Leu Ala Pro Lys 
    290                 295                 300                 


Asn Val Ser Ile Ala Glu Leu Leu Glu Leu Tyr Thr Gly Asp Pro Val 
305                 310                 315                 320 


Ile Asp Ile Lys Arg Asn Leu Met Thr Phe Arg Phe Ala Glu Ala Val 
                325                 330                 335     


Val Glu Val Thr Ala Arg Lys Ile Val Glu Lys Tyr His Asn Lys Tyr 
            340                 345                 350         


Leu Leu Lys Leu Thr Glu Pro Lys Gly Lys Pro Val Arg Glu Ile Gly 
        355                 360                 365             


Leu Val Ser Ile Asp Leu Asn Val Gln Arg Leu Ile Ala Leu Ala Ile 
    370                 375                 380                 


Tyr Arg Val His Gln Thr Gly Glu Ser Gln Leu Ala Leu Ser Pro Cys 
385                 390                 395                 400 


Leu His Arg Glu Ile Leu Pro Ala Lys Gly Leu Gly Asp Phe Asp Lys 
                405                 410                 415     


Tyr Lys Ser Lys Phe Asn Gln Leu Thr Glu Glu Ile Leu Thr Ala Ala 
            420                 425                 430         


Val Gln Thr Leu Thr Ser Ala Gln Gln Glu Glu Tyr Gln Arg Tyr Val 
        435                 440                 445             


Glu Glu Ser Ser His Glu Ala Lys Ala Asp Leu Cys Leu Lys Tyr Ser 
    450                 455                 460                 


Ile Thr Pro His Glu Leu Ala Trp Asp Lys Met Thr Ser Ser Thr Gln 
465                 470                 475                 480 


Tyr Ile Ser Arg Trp Leu Arg Asp His Gly Trp Asn Ala Ser Asp Phe 
                485                 490                 495     


Thr Gln Ile Thr Lys Gly Arg Lys Lys Val Glu Arg Leu Trp Ser Asp 
            500                 505                 510         


Ser Arg Trp Ala Gln Glu Leu Lys Pro Lys Leu Ser Asn Glu Thr Arg 
        515                 520                 525             


Arg Lys Leu Glu Asp Ala Lys His Asp Leu Gln Arg Ala Asn Pro Glu 
    530                 535                 540                 


Trp Gln Arg Leu Ala Lys Arg Lys Gln Glu Tyr Ser Arg His Leu Ala 
545                 550                 555                 560 


Asn Thr Val Leu Ser Met Ala Arg Glu Tyr Thr Ala Cys Glu Thr Val 
                565                 570                 575     


Val Ile Ala Ile Glu Asn Leu Pro Met Lys Gly Gly Phe Val Asp Gly 
            580                 585                 590         


Asn Gly Ser Arg Glu Ser Gly Trp Asp Asn Phe Phe Thr His Lys Lys 
        595                 600                 605             


Glu Asn Arg Trp Met Ile Lys Asp Ile His Lys Ala Leu Ser Asp Leu 
    610                 615                 620                 


Ala Pro Asn Arg Gly Val His Val Leu Glu Val Asn Pro Gln Tyr Thr 
625                 630                 635                 640 


Ser Gln Thr Cys Pro Glu Cys Gly His Arg Asp Lys Ala Asn Arg Asp 
                645                 650                 655     


Pro Ile Gln Arg Glu Arg Phe Cys Cys Thr His Cys Gly Ala Gln Arg 
            660                 665                 670         


His Ala Asp Leu Glu Val Ala Thr His Asn Ile Ala Met Val Ala Thr 
        675                 680                 685             


Thr Gly Lys Ser Leu Thr Gly Lys Ser Leu Ala Pro Gln Arg Leu Gln 
    690                 695                 700                 


Glu Ala Ala Glu 
705             


<210> 188
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 188
Val Leu Leu Ser Asp Arg Ile Gln Tyr Thr Asp Pro Ser Ala Pro Ile 
1               5                   10                  15      


Pro Ala Met Thr Val Val Asp Arg Arg Lys Ile Lys Lys Gly Glu Pro 
            20                  25                  30          


Gly Tyr Val Pro Pro Phe Met Arg Lys Asn Leu Ser Thr Asn Lys His 
        35                  40                  45              


Arg Arg Met Arg Leu Ser Arg Gly Gln Lys Glu Ala Cys Ala Leu Pro 
    50                  55                  60                  


Val Gly Leu Arg Leu Pro Asp Gly Lys Asp Gly Trp Asp Phe Ile Ile 
65                  70                  75                  80  


Phe Asp Gly Arg Ala Leu Leu Arg Ala Cys Arg Arg Leu Arg Leu Glu 
                85                  90                  95      


Val Thr Ser Met Asp Asp Val Leu Asp Lys Phe Thr Gly Asp Pro Arg 
            100                 105                 110         


Ile Gln Leu Ser Pro Ala Gly Glu Thr Ile Val Thr Cys Met Leu Lys 
        115                 120                 125             


Pro Gln His Thr Gly Val Ile Gln Gln Lys Leu Ile Thr Gly Lys Met 
    130                 135                 140                 


Lys Asp Arg Leu Val Gln Leu Thr Ala Glu Ala Pro Ile Ala Met Leu 
145                 150                 155                 160 


Thr Val Asp Leu Gly Glu His Asn Leu Val Ala Cys Gly Ala Tyr Thr 
                165                 170                 175     


Val Gly Gln Arg Arg Gly Lys Leu Gln Ser Glu Arg Leu Glu Ala Phe 
            180                 185                 190         


Leu Leu Pro Glu Lys Val Leu Ala Asp Phe Glu Gly Tyr Arg Arg Asp 
        195                 200                 205             


Ser Asp Glu His Ser Glu Thr Leu Arg His Glu Ala Leu Lys Ala Leu 
    210                 215                 220                 


Ser Lys Arg Gln Gln Arg Glu Val Leu Asp Met Leu Arg Thr Gly Ala 
225                 230                 235                 240 


Asp Gln Ala Arg Glu Ser Leu Cys Tyr Lys Tyr Gly Leu Asp Leu Gln 
                245                 250                 255     


Ala Leu Pro Trp Asp Lys Met Ser Ser Asn Ser Thr Phe Ile Ala Gln 
            260                 265                 270         


His Leu Met Ser Leu Gly Phe Gly Glu Ser Ala Thr His Val Arg Tyr 
        275                 280                 285             


Arg Pro Lys Arg Lys Ala Ser Glu Arg Thr Ile Leu Lys Tyr Asp Ser 
    290                 295                 300                 


Arg Phe Ala Ala Glu Glu Lys Ile Lys Leu Thr Asp Glu Thr Arg Arg 
305                 310                 315                 320 


Ala Trp Asn Glu Ala Ile Trp Glu Cys Gln Arg Ala Ser Gln Glu Phe 
                325                 330                 335     


Arg Cys Leu Ser Val Arg Lys Leu Gln Leu Ala Arg Ala Ala Val Asn 
            340                 345                 350         


Trp Thr Leu Thr Gln Ala Lys Gln Arg Ser Arg Cys Pro Arg Val Val 
        355                 360                 365             


Val Val Val Glu Asp Leu Asn Val Arg Phe Met His Gly Gly Gly Lys 
    370                 375                 380                 


Arg Gln Glu Gly Trp Ala Gly Phe Phe Lys Ala Arg Ser Glu Lys Arg 
385                 390                 395                 400 


Trp Phe Ile Gln Ala Leu His Lys Ala Tyr Thr Glu Leu Pro Thr Asn 
                405                 410                 415     


Arg Gly Ile His Val Met Glu Val Asn Pro Ala Arg Thr Ser Ile Thr 
            420                 425                 430         


Cys Thr Lys Cys Gly Tyr Cys Asp Pro Glu Asn Arg Tyr Gly Glu Asp 
        435                 440                 445             


Phe His Cys Arg Asn Pro Lys Cys Lys Val Arg Gly Gly His Val Ala 
    450                 455                 460                 


Asn Ala Asp Leu Asp Ile Ala Thr Glu Asn Leu Ala Arg Val Ala Leu 
465                 470                 475                 480 


Ser Gly Pro Met Pro Lys Ala Pro Lys Leu Lys 
                485                 490     


<210> 189
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 189
Met Thr Pro Ser Phe Gly Tyr Gln Met Ile Ile Val Thr Pro Ile His 
1               5                   10                  15      


His Ala Ser Gly Ala Trp Ala Thr Leu Arg Leu Leu Phe Leu Asn Pro 
            20                  25                  30          


Lys Thr Ser Gly Val Met Leu Gly Met Thr Lys Thr Lys Ser Ala Phe 
        35                  40                  45              


Ala Leu Met Arg Glu Glu Val Phe Pro Gly Leu Leu Phe Lys Ser Ala 
    50                  55                  60                  


Asp Leu Lys Met Ala Gly Arg Lys Phe Ala Lys Glu Gly Arg Glu Ala 
65                  70                  75                  80  


Ala Ile Glu Tyr Leu Arg Gly Lys Asp Glu Glu Arg Pro Ala Asn Phe 
                85                  90                  95      


Lys Pro Pro Ala Lys Gly Asp Ile Ile Ala Gln Ser Arg Pro Phe Asp 
            100                 105                 110         


Gln Trp Pro Ile Val Gln Val Ser Gln Ala Ile Gln Lys Tyr Ile Phe 
        115                 120                 125             


Gly Leu Thr Lys Ala Glu Phe Asp Ala Thr Lys Thr Leu Leu Tyr Gly 
    130                 135                 140                 


Glu Gly Asn His Pro Thr Thr Glu Ser Arg Arg Arg Trp Phe Glu Ala 
145                 150                 155                 160 


Thr Gly Val Pro Asp Phe Gly Phe Thr Ser Ala Gln Gly Leu Asn Ala 
                165                 170                 175     


Ile Phe Ser Ser Ala Leu Ala Arg Tyr Glu Gly Val Ile Gln Lys Val 
            180                 185                 190         


Glu Asn Arg Asn Glu Lys Arg Leu Lys Lys Leu Ser Glu Lys Asn Gln 
        195                 200                 205             


Arg Leu Val Glu Glu Gly His Ala Val Glu Ala Tyr Val Pro Glu Thr 
    210                 215                 220                 


Ala Phe His Thr Leu Glu Ser Leu Lys Ala Leu Ser Glu Lys Ser Leu 
225                 230                 235                 240 


Val Pro Leu Asp Asp Leu Met Asp Lys Ile Asp Arg Leu Ala Gln Pro 
                245                 250                 255     


Pro Gly Ile Asn Pro Cys Leu Tyr Gly Tyr Gln Gln Val Ala Pro Tyr 
            260                 265                 270         


Ile Tyr Asp Pro Glu Asn Pro Arg Gly Val Val Leu Pro Asp Leu Tyr 
        275                 280                 285             


Leu Gly Tyr Cys Arg Lys Pro Asp Asp Pro Ile Thr Ala Cys Pro Asn 
    290                 295                 300                 


Arg Leu Asp Ile Pro Lys Gly Gln Pro Gly Tyr Ile Pro Glu His Gln 
305                 310                 315                 320 


Arg Gly Gln Leu Lys Lys His Gly Arg Val Arg Arg Phe Arg Tyr Thr 
                325                 330                 335     


Asn Pro Gln Ala Lys Ala Arg Ala Lys Ala Gln Thr Ala Ile Leu Ala 
            340                 345                 350         


Val Leu Arg Ile Asp Glu Asp Trp Val Val Met Asp Leu Arg Gly Leu 
        355                 360                 365             


Leu Arg Asn Val Tyr Phe Arg Glu Val Ala Ala Pro Gly Glu Leu Thr 
    370                 375                 380                 


Ala Arg Thr Leu Leu Asp Thr Phe Thr Gly Cys Pro Val Leu Asn Leu 
385                 390                 395                 400 


Arg Ser Asn Val Val Thr Phe Cys Tyr Asp Ile Glu Ser Lys Gly Ala 
                405                 410                 415     


Leu His Ala Glu Tyr Val Arg Lys Gly Trp Ala Thr Arg Asn Lys Leu 
            420                 425                 430         


Leu Asp Leu Thr Lys Asp Gly Gln Ser Val Ala Leu Leu Ser Val Asp 
        435                 440                 445             


Leu Gly Gln Arg His Pro Val Ala Val Met Ile Ser Arg Leu Lys Arg 
    450                 455                 460                 


Asp Asp Lys Gly Asp Leu Ser Glu Lys Ser Ile Gln Val Val Ser Arg 
465                 470                 475                 480 


Thr Phe Ala Asp Gln Tyr Val Asp Lys Leu Lys Arg Tyr Arg Val Gln 
                485                 490                 495     


Tyr Asp Ala Leu Arg Lys Glu Ile Tyr Asp Ala Ala Leu Val Ser Leu 
            500                 505                 510         


Pro Pro Glu Gln Gln Ala Glu Ile Arg Ala Tyr Glu Ala Phe Ala Pro 
        515                 520                 525             


Gly Asp Ala Lys Ala Asn Val Leu Ser Val Met Phe Gln Gly Glu Val 
    530                 535                 540                 


Ser Pro Asp Glu Leu Pro Trp Asp Lys Met Asn Thr Asn Thr His Tyr 
545                 550                 555                 560 


Ile Ser Asp Leu Tyr Leu Arg Arg Gly Gly Asp Pro Ser Arg Val Phe 
                565                 570                 575     


Phe Val Pro Gln Pro Ser Thr Pro Lys Lys Asn Ala Lys Lys Pro Pro 
            580                 585                 590         


Ala Pro Arg Lys Pro Val Lys Arg Thr Asp Glu Asn Val Ser His Met 
        595                 600                 605             


Pro Glu Phe Arg Pro His Leu Ser Asn Glu Thr Arg Glu Ala Phe Gln 
    610                 615                 620                 


Lys Ala Lys Trp Thr Met Glu Arg Gly Asn Val Arg Tyr Ala Gln Leu 
625                 630                 635                 640 


Ser Arg Phe Leu Asn Gln Ile Val Arg Glu Ala Asn Asn Trp Leu Val 
                645                 650                 655     


Ser Glu Ala Lys Lys Leu Thr Gln Cys Gln Thr Val Val Trp Ala Ile 
            660                 665                 670         


Glu Asp Leu His Val Pro Phe Phe His Gly Lys Gly Lys Tyr His Glu 
        675                 680                 685             


Thr Trp Asp Gly Phe Phe Arg Gln Lys Lys Glu Asp Arg Trp Phe Val 
    690                 695                 700                 


Asn Val Phe His Lys Ala Ile Ser Glu Arg Ala Pro Asn Lys Gly Glu 
705                 710                 715                 720 


Tyr Val Met Glu Val Ala Pro Tyr Arg Thr Ser Gln Arg Cys Pro Val 
                725                 730                 735     


Cys Gly Phe Val Asp Ala Asp Asn Arg His Gly Asp His Phe Lys Cys 
            740                 745                 750         


Leu Arg Cys Gly Val Glu Leu His Ala Asp Leu Glu Val Ala Thr Trp 
        755                 760                 765             


Asn Ile Ala Leu Val Ala Val Gln Gly His Gly Ile Ala Gly Pro Pro 
    770                 775                 780                 


Arg Glu Gln Ser Cys Gly Gly Glu Thr Ala Gly Thr Ala Arg Lys Gly 
785                 790                 795                 800 


Lys Asn Ile Lys Lys Asn Lys Gly Leu Ala Asp Ala Val Thr Val Glu 
                805                 810                 815     


Ala Gln Asp Ser Glu Gly Gly Ser Lys Lys Asp Ala Gly Thr Ala Arg 
            820                 825                 830         


Asn Pro Val Tyr Ile Pro Ser Glu Ser Gln Val Asn Cys Pro Ala Pro 
        835                 840                 845             


<210> 190
<211> 781
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 190
Met Lys Pro Lys Thr Pro Lys Pro Pro Lys Thr Pro Val Ala Ala Leu 
1               5                   10                  15      


Ile Asp Lys His Phe Pro Gly Lys Arg Phe Arg Ala Ser Tyr Leu Lys 
            20                  25                  30          


Ser Val Gly Lys Lys Leu Lys Asn Gln Gly Glu Asp Val Ala Val Arg 
        35                  40                  45              


Phe Leu Thr Gly Lys Asp Glu Glu Arg Pro Pro Asn Phe Gln Pro Pro 
    50                  55                  60                  


Ala Lys Ser Asn Ile Val Ala Gln Ser Arg Pro Ile Glu Glu Trp Pro 
65                  70                  75                  80  


Ile His Lys Val Ser Val Ala Val Gln Glu Tyr Val Tyr Gly Leu Thr 
                85                  90                  95      


Val Ala Glu Lys Glu Ala Cys Ser Asp Ala Gly Glu Ser Ser Ser Ser 
            100                 105                 110         


His Ala Ala Trp Phe Ala Lys Thr Gly Val Glu Asn Phe Gly Tyr Thr 
        115                 120                 125             


Ser Val Gln Gly Leu Asn Lys Ile Phe Pro Pro Thr Phe Asn Arg Phe 
    130                 135                 140                 


Asp Gly Val Ile Lys Lys Val Glu Asn Arg Asn Glu Lys Lys Arg Gln 
145                 150                 155                 160 


Lys Ala Thr Arg Ile Asn Glu Ala Lys Arg Asn Lys Gly Gln Ser Glu 
                165                 170                 175     


Asp Pro Pro Glu Ala Glu Val Lys Ala Thr Asp Asp Ala Gly Tyr Leu 
            180                 185                 190         


Leu Gln Pro Pro Gly Ile Asn His Ser Val Tyr Gly Tyr Gln Ser Ile 
        195                 200                 205             


Thr Leu Cys Pro Tyr Thr Ala Glu Lys Phe Pro Thr Ile Lys Leu Pro 
    210                 215                 220                 


Glu Glu Tyr Ala Gly Tyr His Ser Asn Pro Asp Ala Pro Ile Pro Ala 
225                 230                 235                 240 


Gly Val Pro Asp Arg Leu Ala Ile Pro Glu Gly Gln Pro Gly His Val 
                245                 250                 255     


Pro Glu Glu His Arg Ala Gly Leu Ser Thr Lys Lys His Arg Arg Val 
            260                 265                 270         


Arg Gln Trp Tyr Ala Met Ala Asn Trp Lys Pro Lys Pro Lys Arg Thr 
        275                 280                 285             


Ser Lys Pro Asp Tyr Asp Arg Leu Ala Lys Ala Arg Ala Gln Gly Ala 
    290                 295                 300                 


Leu Leu Ile Val Ile Arg Ile Asp Glu Asp Trp Val Val Val Asp Ala 
305                 310                 315                 320 


Arg Gly Leu Leu Arg Asn Val Arg Trp Arg Ser Leu Gly Lys Arg Glu 
                325                 330                 335     


Ile Thr Pro Asn Glu Leu Leu Asp Leu Phe Thr Gly Asp Pro Val Leu 
            340                 345                 350         


Asp Leu Lys Arg Gly Val Val Thr Phe Thr Tyr Ala Glu Gly Val Val 
        355                 360                 365             


Asn Val Cys Ser Arg Ser Thr Thr Lys Gly Lys Gln Thr Lys Val Leu 
    370                 375                 380                 


Leu Asp Ala Met Thr Ala Pro Arg Asp Gly Lys Lys Arg Gln Ile Gly 
385                 390                 395                 400 


Met Val Ala Val Asp Leu Gly Gln Thr Asn Pro Ile Ala Ala Glu Tyr 
                405                 410                 415     


Ser Arg Val Gly Lys Asn Ala Ala Gly Thr Leu Glu Ala Thr Pro Leu 
            420                 425                 430         


Ser Arg Ser Thr Leu Pro Asp Glu Leu Leu Arg Glu Ile Ala Leu Tyr 
        435                 440                 445             


Arg Lys Ala His Asp Arg Leu Glu Ala Gln Leu Arg Glu Glu Ala Val 
    450                 455                 460                 


Leu Lys Leu Thr Ala Glu Gln Gln Ala Glu Asn Ala Arg Tyr Val Glu 
465                 470                 475                 480 


Thr Ser Glu Glu Gly Ala Lys Leu Ala Leu Ala Asn Leu Gly Val Asp 
                485                 490                 495     


Thr Ser Thr Leu Pro Trp Asp Ala Met Thr Gly Trp Ser Thr Cys Ile 
            500                 505                 510         


Ser Asp His Leu Ile Asn His Gly Gly Asp Thr Ser Ala Val Phe Phe 
        515                 520                 525             


Gln Thr Ile Arg Lys Gly Thr Lys Lys Leu Glu Thr Ile Lys Arg Lys 
    530                 535                 540                 


Asp Ser Ser Trp Ala Asp Ile Val Arg Pro Arg Leu Thr Lys Glu Thr 
545                 550                 555                 560 


Arg Glu Ala Leu Asn Asp Phe Leu Trp Glu Leu Lys Arg Ser His Glu 
                565                 570                 575     


Gly Tyr Glu Lys Leu Ser Lys Arg Leu Glu Glu Leu Ala Arg Arg Ala 
            580                 585                 590         


Val Asn His Val Val Gln Glu Val Lys Trp Leu Thr Gln Cys Gln Asp 
        595                 600                 605             


Ile Val Ile Val Ile Glu Asp Leu Asn Val Arg Asn Phe His Gly Gly 
    610                 615                 620                 


Gly Lys Arg Gly Gly Gly Trp Ser Asn Phe Phe Thr Val Lys Lys Glu 
625                 630                 635                 640 


Asn Arg Trp Phe Met Gln Ala Leu His Lys Ala Phe Ser Asp Leu Ala 
                645                 650                 655     


Ala His Arg Gly Ile Pro Val Leu Glu Val Tyr Pro Ala Arg Thr Ser 
            660                 665                 670         


Ile Thr Cys Leu Gly Cys Gly His Cys Asp Pro Glu Asn Arg Asp Gly 
        675                 680                 685             


Glu Ala Phe Val Cys Gln Gln Cys Gly Ala Thr Phe His Ala Asp Leu 
    690                 695                 700                 


Glu Val Ala Thr Arg Asn Ile Ala Arg Val Ala Leu Thr Gly Glu Ala 
705                 710                 715                 720 


Met Pro Lys Ala Pro Ala Arg Glu Gln Pro Gly Gly Ala Lys Lys Arg 
                725                 730                 735     


Gly Thr Ser Arg Arg Arg Lys Leu Thr Glu Val Ala Val Lys Ser Ala 
            740                 745                 750         


Glu Pro Thr Ile His Gln Ala Lys Asn Gln Gln Leu Asn Gly Thr Ser 
        755                 760                 765             


Arg Asp Pro Val Tyr Lys Gly Ser Glu Leu Pro Ala Leu 
    770                 775                 780     


<210> 191
<211> 767
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 191
Met Ser Glu Ile Thr Asp Leu Leu Lys Ala Asn Phe Lys Gly Lys Thr 
1               5                   10                  15      


Phe Lys Ser Ala Asp Met Arg Met Ala Gly Arg Ile Leu Lys Lys Ser 
            20                  25                  30          


Gly Ala Gln Ala Val Ile Lys Tyr Leu Ser Asp Lys Gly Ala Val Asp 
        35                  40                  45              


Pro Pro Asp Phe Arg Pro Pro Ala Lys Cys Asn Ile Ile Ala Gln Ser 
    50                  55                  60                  


Arg Pro Phe Asp Glu Trp Pro Ile Cys Lys Ala Ser Met Ala Ile Gln 
65                  70                  75                  80  


Gln His Ile Tyr Gly Leu Thr Lys Asn Glu Phe Asp Glu Ser Ser Pro 
                85                  90                  95      


Gly Thr Ser Ser Ala Ser His Glu Gln Trp Phe Ala Lys Thr Gly Val 
            100                 105                 110         


Asp Thr His Gly Phe Thr His Val Gln Gly Leu Asn Leu Ile Phe Gln 
        115                 120                 125             


His Ala Lys Lys Arg Tyr Glu Gly Val Ile Lys Lys Val Glu Asn Tyr 
    130                 135                 140                 


Asn Glu Lys Glu Arg Lys Lys Phe Glu Gly Ile Asn Glu Arg Arg Ser 
145                 150                 155                 160 


Lys Glu Gly Met Pro Leu Leu Glu Pro Arg Leu Arg Thr Ala Phe Gly 
                165                 170                 175     


Asp Asp Gly Lys Phe Ala Glu Lys Pro Gly Val Asn Pro Ser Ile Tyr 
            180                 185                 190         


Leu Tyr Gln Gln Thr Ser Pro Arg Pro Tyr Asp Lys Thr Lys His Pro 
        195                 200                 205             


Tyr Val His Ala Pro Phe Glu Leu Lys Glu Ile Thr Thr Ile Pro Thr 
    210                 215                 220                 


Gln Asp Asp Arg Leu Lys Ile Pro Phe Gly Ala Pro Gly His Val Pro 
225                 230                 235                 240 


Glu Lys His Arg Ser Gln Leu Ser Met Ala Lys His Lys Arg Arg Arg 
                245                 250                 255     


Ala Trp Tyr Ala Leu Ser Gln Asn Lys Pro Arg Pro Pro Lys Asp Gly 
            260                 265                 270         


Ser Lys Gly Arg Arg Ser Val Arg Asp Leu Ala Asp Leu Lys Ala Ala 
        275                 280                 285             


Ser Leu Ala Asp Ala Ile Pro Leu Val Ser Arg Val Gly Phe Asp Trp 
    290                 295                 300                 


Val Val Ile Asp Gly Arg Gly Leu Leu Arg Asn Leu Arg Trp Arg Lys 
305                 310                 315                 320 


Leu Ala His Glu Gly Met Thr Val Glu Glu Met Leu Gly Phe Phe Ser 
                325                 330                 335     


Gly Asp Pro Val Ile Asp Pro Arg Arg Asn Val Ala Thr Phe Ile Tyr 
            340                 345                 350         


Lys Ala Glu His Ala Thr Val Lys Ser Arg Lys Pro Ile Gly Gly Ala 
        355                 360                 365             


Lys Arg Ala Arg Glu Glu Leu Leu Lys Ala Thr Ala Ser Ser Asp Gly 
    370                 375                 380                 


Val Ile Arg Gln Val Gly Leu Ile Ser Val Asp Leu Gly Gln Thr Asn 
385                 390                 395                 400 


Pro Val Ala Tyr Glu Ile Ser Arg Met His Gln Ala Asn Gly Glu Leu 
                405                 410                 415     


Val Ala Glu His Leu Glu Tyr Gly Leu Leu Asn Asp Glu Gln Val Asn 
            420                 425                 430         


Ser Ile Gln Arg Tyr Arg Ala Ala Trp Asp Ser Met Asn Glu Ser Phe 
        435                 440                 445             


Arg Gln Lys Ala Ile Glu Ser Leu Ser Met Glu Ala Gln Asp Glu Ile 
    450                 455                 460                 


Met Gln Ala Ser Thr Gly Ala Ala Lys Arg Thr Arg Glu Ala Val Leu 
465                 470                 475                 480 


Thr Met Phe Gly Pro Asn Ala Thr Leu Pro Trp Ser Arg Met Ser Ser 
                485                 490                 495     


Asn Thr Thr Cys Ile Ser Asp Ala Leu Ile Glu Val Gly Lys Glu Glu 
            500                 505                 510         


Glu Thr Asn Phe Val Thr Ser Asn Gly Pro Arg Lys Arg Thr Asp Ala 
        515                 520                 525             


Gln Trp Ala Ala Tyr Leu Arg Pro Arg Val Asn Pro Glu Thr Arg Ala 
    530                 535                 540                 


Leu Leu Asn Gln Ala Val Trp Asp Leu Met Lys Arg Ser Asp Glu Tyr 
545                 550                 555                 560 


Glu Arg Leu Ser Lys Arg Lys Leu Glu Met Ala Arg Gln Cys Val Asn 
                565                 570                 575     


Phe Val Val Ala Arg Ala Glu Lys Leu Thr Gln Cys Asn Asn Ile Gly 
            580                 585                 590         


Ile Val Leu Glu Asn Leu Val Val Arg Asn Phe His Gly Ser Gly Arg 
        595                 600                 605             


Arg Glu Ser Gly Trp Glu Gly Phe Phe Glu Pro Lys Arg Glu Asn Arg 
    610                 615                 620                 


Trp Phe Met Gln Val Leu His Lys Ala Phe Ser Asp Leu Ala Gln His 
625                 630                 635                 640 


Arg Gly Val Met Val Phe Glu Val His Pro Ala Tyr Ser Ser Gln Thr 
                645                 650                 655     


Cys Pro Ala Cys Arg Tyr Val Asp Pro Lys Asn Arg Ser Ser Glu Asp 
            660                 665                 670         


Arg Glu Arg Phe Lys Cys Leu Lys Cys Gly Arg Ser Phe Asn Ala Asp 
        675                 680                 685             


Arg Glu Val Ala Thr Phe Asn Ile Arg Glu Ile Ala Arg Thr Gly Val 
    690                 695                 700                 


Gly Leu Pro Lys Pro Asp Cys Glu Arg Ser Arg Gly Val Gln Thr Thr 
705                 710                 715                 720 


Gly Thr Ala Arg Asn Pro Gly Arg Ser Leu Lys Ser Asn Lys Asn Pro 
                725                 730                 735     


Ser Glu Pro Lys Arg Val Leu Gln Ser Lys Thr Arg Lys Lys Ile Thr 
            740                 745                 750         


Ser Thr Glu Thr Gln Asn Glu Pro Leu Ala Thr Asp Leu Lys Thr 
        755                 760                 765         


<210> 192
<211> 760
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 192
Met Thr Pro Lys Thr Glu Ser Pro Leu Ser Ala Leu Cys Lys Lys His 
1               5                   10                  15      


Phe Pro Gly Lys Arg Phe Arg Thr Asn Tyr Leu Lys Asp Ala Gly Lys 
            20                  25                  30          


Ile Leu Lys Lys His Gly Glu Asp Ala Val Val Ala Phe Leu Ser Asp 
        35                  40                  45              


Lys Gln Glu Asp Glu Pro Ala Asn Phe Cys Pro Pro Ala Lys Val His 
    50                  55                  60                  


Ile Leu Ala Gln Ser Arg Pro Phe Glu Asp Trp Pro Ile Asn Leu Ala 
65                  70                  75                  80  


Ser Lys Ala Ile Gln Thr Tyr Val Tyr Gly Leu Thr Ala Asp Glu Arg 
                85                  90                  95      


Lys Thr Cys Glu Pro Gly Thr Ser Lys Glu Ser His Asp Arg Trp Phe 
            100                 105                 110         


Lys Glu Thr Gly Val Asp His His Gly Phe Thr Ser Val Gln Gly Leu 
        115                 120                 125             


Asn Leu Ile Phe Lys His Thr Leu Asn Arg Tyr Asp Gly Val Ile Lys 
    130                 135                 140                 


Lys Val Glu Thr Arg Asn Glu Lys Arg Arg Ser Ser Val Val Arg Ile 
145                 150                 155                 160 


Asn Glu Lys Lys Ala Ala Glu Gly Leu Pro Leu Ile Ala Ala Glu Ala 
                165                 170                 175     


Glu Glu Thr Ala Phe Gly Glu Asp Gly Arg Leu Leu Gln Pro Pro Gly 
            180                 185                 190         


Val Asn His Ser Ile Tyr Cys Phe Gln Gln Val Ser Pro Gln Pro Tyr 
        195                 200                 205             


Ser Ser Lys Lys His Pro Gln Val Val Leu Pro His Ala Val Gln Gly 
    210                 215                 220                 


Val Asp Pro Asp Ala Pro Ile Pro Val Gly Arg Pro Asn Arg Leu Asp 
225                 230                 235                 240 


Ile Pro Lys Gly Gln Pro Gly Tyr Val Pro Glu Trp Gln Arg Pro His 
                245                 250                 255     


Leu Ser Met Lys Cys Lys Arg Val Arg Met Trp Tyr Ala Arg Ala Asn 
            260                 265                 270         


Trp Arg Arg Lys Pro Gly Arg Arg Ser Val Leu Asn Glu Ala Arg Leu 
        275                 280                 285             


Lys Glu Ala Ser Ala Lys Gly Ala Leu Pro Ile Val Leu Val Ile Gly 
    290                 295                 300                 


Asp Asp Trp Leu Val Met Asp Ala Arg Gly Leu Leu Arg Ser Val Phe 
305                 310                 315                 320 


Trp Arg Arg Val Ala Lys Pro Gly Leu Ser Leu Ser Glu Leu Leu Asn 
                325                 330                 335     


Val Thr Pro Thr Gly Leu Phe Ser Gly Asp Pro Val Ile Asp Pro Lys 
            340                 345                 350         


Arg Gly Leu Val Thr Phe Thr Ser Lys Leu Gly Val Val Ala Val His 
        355                 360                 365             


Ser Arg Lys Pro Thr Arg Gly Lys Lys Ser Lys Asp Leu Leu Leu Lys 
    370                 375                 380                 


Met Thr Lys Pro Thr Asp Asp Gly Met Pro Arg His Val Gly Met Val 
385                 390                 395                 400 


Ala Ile Asp Leu Gly Gln Thr Asn Pro Val Ala Ala Glu Tyr Ser Arg 
                405                 410                 415     


Val Val Gln Ser Asp Ala Gly Thr Leu Lys Gln Glu Pro Val Ser Arg 
            420                 425                 430         


Gly Val Leu Pro Asp Asp Leu Leu Lys Asp Val Ala Arg Tyr Arg Arg 
        435                 440                 445             


Ala Tyr Asp Leu Thr Glu Glu Ser Ile Arg Gln Glu Ala Ile Ala Leu 
    450                 455                 460                 


Leu Ser Glu Gly His Arg Ala Glu Val Thr Lys Leu Asp Gln Thr Thr 
465                 470                 475                 480 


Ala Asn Glu Thr Lys Arg Leu Leu Val Asp Arg Gly Val Ser Glu Ser 
                485                 490                 495     


Leu Pro Trp Glu Lys Met Ser Ser Asn Thr Thr Tyr Ile Ser Asp Cys 
            500                 505                 510         


Leu Val Ala Leu Gly Lys Thr Asp Asp Val Phe Phe Val Pro Lys Ala 
        515                 520                 525             


Lys Lys Gly Lys Lys Glu Thr Gly Ile Ala Val Lys Arg Lys Asp His 
    530                 535                 540                 


Gly Trp Ser Lys Leu Leu Arg Pro Arg Thr Ser Pro Glu Ala Arg Lys 
545                 550                 555                 560 


Ala Leu Asn Glu Asn Gln Trp Ala Val Lys Arg Ala Ser Pro Glu Tyr 
                565                 570                 575     


Glu Arg Leu Ser Arg Arg Lys Leu Glu Leu Gly Arg Arg Cys Val Asn 
            580                 585                 590         


His Ile Ile Gln Glu Thr Lys Arg Trp Thr Gln Cys Glu Asp Ile Val 
        595                 600                 605             


Val Val Leu Glu Asp Leu Asn Val Gly Phe Phe His Gly Ser Gly Lys 
    610                 615                 620                 


Arg Pro Asp Gly Trp Asp Asn Phe Phe Val Ser Lys Arg Glu Asn Arg 
625                 630                 635                 640 


Trp Phe Ile Gln Val Leu His Lys Ala Phe Gly Asp Leu Ala Thr His 
                645                 650                 655     


Arg Gly Thr His Val Ile Glu Val His Pro Ala Arg Thr Ser Ile Thr 
            660                 665                 670         


Cys Ile Lys Cys Gly His Cys Asp Ala Gly Asn Arg Asp Gly Glu Ser 
        675                 680                 685             


Phe Val Cys Leu Ala Ser Ala Cys Gly Asp Arg Arg His Ala Asp Leu 
    690                 695                 700                 


Glu Val Ala Thr Arg Asn Val Ala Arg Val Ala Ile Thr Gly Glu Arg 
705                 710                 715                 720 


Met Pro Pro Ser Glu Gln Ala Arg Asp Val Gln Lys Ala Gly Gly Ala 
                725                 730                 735     


Arg Lys Arg Lys Pro Ser Ala Arg Asn Val Lys Ser Ser Tyr Pro Ala 
            740                 745                 750         


Val Glu Pro Ala Pro Ala Ser Pro 
        755                 760 


<210> 193
<211> 752
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 193
Met Ser Asp Asn Lys Met Lys Lys Leu Ser Lys Glu Glu Lys Pro Leu 
1               5                   10                  15      


Thr Pro Leu Gln Ile Leu Ile Arg Lys Tyr Ile Asp Lys Ser Gln Tyr 
            20                  25                  30          


Pro Ser Gly Phe Lys Thr Thr Ile Ile Lys Gln Ala Gly Val Arg Ile 
        35                  40                  45              


Lys Ser Val Lys Ser Glu Gln Asp Glu Ile Asn Leu Ala Asn Trp Ile 
    50                  55                  60                  


Ile Ser Lys Tyr Asp Pro Thr Tyr Ile Lys Arg Asp Phe Asn Pro Ser 
65                  70                  75                  80  


Ala Lys Cys Gln Ile Ile Ala Thr Ser Arg Ser Val Ala Asp Phe Asp 
                85                  90                  95      


Ile Val Lys Met Ser Asn Lys Val Gln Glu Ile Phe Phe Ala Ser Ser 
            100                 105                 110         


His Leu Asp Lys Asn Val Phe Asp Ile Gly Lys Ser Lys Ser Asp His 
        115                 120                 125             


Asp Ser Trp Phe Glu Arg Asn Asn Val Asp Arg Gly Ile Tyr Thr Tyr 
    130                 135                 140                 


Ser Asn Val Gln Gly Met Asn Leu Ile Phe Ser Asn Thr Lys Asn Thr 
145                 150                 155                 160 


Tyr Leu Gly Val Ala Val Lys Ala Gln Asn Lys Phe Ser Ser Lys Met 
                165                 170                 175     


Lys Arg Ile Gln Asp Ile Asn Asn Phe Arg Ile Thr Asn His Gln Ser 
            180                 185                 190         


Pro Leu Pro Ile Pro Asp Glu Ile Lys Ile Tyr Asp Asp Ala Gly Phe 
        195                 200                 205             


Leu Leu Asn Pro Pro Gly Val Asn Pro Asn Ile Phe Gly Tyr Gln Ser 
    210                 215                 220                 


Cys Leu Leu Lys Pro Leu Glu Asn Lys Glu Ile Ile Ser Lys Thr Ser 
225                 230                 235                 240 


Phe Pro Glu Tyr Ser Arg Leu Pro Ala Asp Met Ile Glu Val Asn Tyr 
                245                 250                 255     


Lys Ile Ser Asn Arg Leu Lys Phe Ser Asn Asp Gln Lys Gly Phe Ile 
            260                 265                 270         


Gln Phe Lys Asp Lys Leu Asn Leu Phe Lys Ile Asn Ser Gln Glu Leu 
        275                 280                 285             


Phe Ser Lys Arg Arg Arg Leu Ser Gly Gln Pro Ile Leu Leu Val Ala 
    290                 295                 300                 


Ser Phe Gly Asp Asp Trp Val Val Leu Asp Gly Arg Gly Leu Leu Arg 
305                 310                 315                 320 


Gln Val Tyr Tyr Arg Gly Ile Ala Lys Pro Gly Ser Ile Thr Ile Ser 
                325                 330                 335     


Glu Leu Leu Gly Phe Phe Thr Gly Asp Pro Ile Val Asp Pro Ile Arg 
            340                 345                 350         


Gly Val Val Ser Leu Gly Phe Lys Pro Gly Val Leu Ser Gln Glu Thr 
        355                 360                 365             


Leu Lys Thr Thr Ser Ala Arg Ile Phe Ala Glu Lys Leu Pro Asn Leu 
    370                 375                 380                 


Val Leu Asn Asn Asn Val Gly Leu Met Ser Ile Asp Leu Gly Gln Thr 
385                 390                 395                 400 


Asn Pro Val Ser Tyr Arg Leu Ser Glu Ile Thr Ser Asn Met Ser Val 
                405                 410                 415     


Glu His Ile Cys Ser Asp Phe Leu Ser Gln Asp Gln Ile Ser Ser Ile 
            420                 425                 430         


Glu Lys Ala Lys Thr Ser Leu Asp Asn Leu Glu Glu Glu Ile Ala Ile 
        435                 440                 445             


Lys Ala Val Asp His Leu Ser Asp Glu Asp Lys Ile Asn Phe Ala Asn 
    450                 455                 460                 


Phe Ser Lys Leu Asn Leu Pro Glu Asp Thr Arg Gln Ser Leu Phe Glu 
465                 470                 475                 480 


Lys Tyr Pro Glu Leu Ile Gly Ser Lys Leu Asp Phe Gly Ser Met Gly 
                485                 490                 495     


Ser Gly Thr Ser Tyr Ile Ala Asp Glu Leu Ile Lys Phe Glu Asn Lys 
            500                 505                 510         


Asp Ala Phe Tyr Pro Ser Gly Lys Lys Lys Phe Asp Leu Ser Phe Ser 
        515                 520                 525             


Arg Asp Leu Arg Lys Lys Leu Ser Asp Glu Thr Arg Lys Ser Tyr Asn 
    530                 535                 540                 


Asp Ala Leu Phe Leu Glu Lys Arg Thr Asn Asp Lys Tyr Leu Lys Asn 
545                 550                 555                 560 


Ala Lys Arg Arg Lys Gln Ile Val Arg Thr Val Ala Asn Ser Leu Val 
                565                 570                 575     


Ser Lys Ile Glu Glu Leu Gly Leu Thr Pro Val Ile Asn Ile Glu Asn 
            580                 585                 590         


Leu Ala Met Ser Gly Gly Phe Phe Asp Gly Arg Gly Lys Arg Glu Lys 
        595                 600                 605             


Gly Trp Asp Asn Phe Phe Lys Val Lys Lys Glu Asn Arg Trp Val Met 
    610                 615                 620                 


Lys Asp Phe His Lys Ala Phe Ser Glu Leu Ser Pro His His Gly Val 
625                 630                 635                 640 


Ile Val Ile Glu Ser Pro Pro Tyr Cys Thr Ser Val Thr Cys Thr Lys 
                645                 650                 655     


Cys Asn Phe Cys Asp Lys Lys Asn Arg Asn Gly His Lys Phe Thr Cys 
            660                 665                 670         


Gln Arg Cys Gly Leu Asp Ala Asn Ala Asp Leu Asp Ile Ala Thr Glu 
        675                 680                 685             


Asn Leu Glu Lys Val Ala Ile Ser Gly Lys Arg Met Pro Gly Ser Glu 
    690                 695                 700                 


Arg Ser Ser Asp Glu Arg Lys Val Ala Val Ala Arg Lys Ala Lys Ser 
705                 710                 715                 720 


Pro Lys Gly Lys Ala Ile Lys Gly Val Lys Cys Thr Ile Thr Asp Glu 
                725                 730                 735     


Pro Ala Leu Leu Ser Ala Asn Ser Gln Asp Cys Ser Gln Ser Thr Ser 
            740                 745                 750         


<210> 194
<211> 747
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 194
Met Ala Leu Ser Leu Ala Glu Val Arg Glu Arg His Phe Lys Gly Leu 
1               5                   10                  15      


Arg Phe Arg Ser Ser Tyr Leu Lys Arg Ala Gly Lys Ile Leu Lys Lys 
            20                  25                  30          


Glu Gly Glu Ala Ala Cys Val Ala Tyr Leu Thr Gly Lys Asp Glu Glu 
        35                  40                  45              


Ser Pro Pro Asn Phe Lys Pro Pro Ala Lys Cys Asp Val Val Ala Gln 
    50                  55                  60                  


Ser Arg Pro Phe Glu Glu Trp Pro Ile Val Gln Ala Ser Val Ala Val 
65                  70                  75                  80  


Gln Ser Tyr Val Tyr Gly Leu Thr Lys Glu Ala Phe Glu Ala Phe Asn 
                85                  90                  95      


Pro Gly Thr Thr Lys Gln Ser His Glu Ala Cys Leu Ala Ala Thr Gly 
            100                 105                 110         


Ile Asp Thr Cys Gly Tyr Ser Asn Val Gln Gly Leu Asn Leu Ile Phe 
        115                 120                 125             


Arg Gln Ala Lys Asn Arg Tyr Glu Gly Val Ile Thr Lys Val Glu Asn 
    130                 135                 140                 


Arg Asn Lys Lys Ala Lys Lys Lys Leu Thr Arg Lys Asn Glu Trp Arg 
145                 150                 155                 160 


Gln Lys Asn Gly His Ser Glu Leu Pro Glu Ala Pro Glu Glu Leu Thr 
                165                 170                 175     


Phe Asn Asp Glu Gly Arg Leu Leu Gln Pro Pro Gly Ile Asn Pro Ser 
            180                 185                 190         


Leu Tyr Thr Tyr Gln Gln Ile Ser Pro Thr Pro Trp Ser Pro Lys Asp 
        195                 200                 205             


Ser Ser Ile Leu Pro Pro Gln Tyr Ala Gly Tyr Glu Arg Asp Pro Asn 
    210                 215                 220                 


Ala Pro Ile Pro Phe Gly Val Ala Lys Asp Arg Leu Thr Ile Ala Ser 
225                 230                 235                 240 


Gly Cys Pro Gly Tyr Ile Pro Glu Trp Met Arg Thr Ala Gly Glu Lys 
                245                 250                 255     


Thr Asn Pro Arg Thr Gln Lys Lys Phe Met His Pro Gly Leu Ser Thr 
            260                 265                 270         


Arg Lys Asn Lys Arg Met Arg Leu Pro Arg Ser Val Arg Ser Ala Pro 
        275                 280                 285             


Leu Gly Ala Leu Leu Val Thr Ile His Leu Gly Glu Asp Trp Leu Val 
    290                 295                 300                 


Leu Asp Val Arg Gly Leu Leu Arg Asn Ala Arg Trp Arg Gly Val Ala 
305                 310                 315                 320 


Pro Lys Asp Ile Ser Thr Gln Gly Leu Leu Asn Leu Phe Thr Gly Asp 
                325                 330                 335     


Pro Val Ile Asp Thr Arg Arg Gly Val Val Thr Phe Thr Tyr Lys Pro 
            340                 345                 350         


Glu Thr Val Gly Ile His Ser Arg Thr Trp Leu Tyr Lys Gly Lys Gln 
        355                 360                 365             


Thr Lys Glu Val Leu Glu Lys Leu Thr Gln Asp Gln Thr Val Ala Leu 
    370                 375                 380                 


Val Ala Ile Asp Leu Gly Gln Thr Asn Pro Val Ser Ala Ala Ala Ser 
385                 390                 395                 400 


Arg Val Ser Arg Ser Gly Glu Asn Leu Ser Ile Glu Thr Val Asp Arg 
                405                 410                 415     


Phe Phe Leu Pro Asp Glu Leu Ile Lys Glu Leu Arg Leu Tyr Arg Met 
            420                 425                 430         


Ala His Asp Arg Leu Glu Glu Arg Ile Arg Glu Glu Ser Thr Leu Ala 
        435                 440                 445             


Leu Thr Glu Ala Gln Gln Ala Glu Val Arg Ala Leu Glu His Val Val 
    450                 455                 460                 


Arg Asp Asp Ala Lys Asn Lys Val Cys Ala Ala Phe Asn Leu Asp Ala 
465                 470                 475                 480 


Ala Ser Leu Pro Trp Asp Gln Met Thr Ser Asn Thr Thr Tyr Leu Ser 
                485                 490                 495     


Glu Ala Ile Leu Ala Gln Gly Val Ser Arg Asp Gln Val Phe Phe Thr 
            500                 505                 510         


Pro Asn Pro Lys Lys Gly Ser Lys Glu Pro Val Glu Val Met Arg Lys 
        515                 520                 525             


Asp Arg Ala Trp Val Tyr Ala Phe Lys Ala Lys Leu Ser Glu Glu Thr 
    530                 535                 540                 


Arg Lys Ala Lys Asn Glu Ala Leu Trp Ala Leu Lys Arg Ala Ser Pro 
545                 550                 555                 560 


Asp Tyr Ala Arg Leu Ser Lys Arg Arg Glu Glu Leu Cys Arg Arg Ser 
                565                 570                 575     


Val Asn Met Val Ile Asn Arg Ala Lys Lys Arg Thr Gln Cys Gln Val 
            580                 585                 590         


Val Ile Pro Val Leu Glu Asp Leu Asn Ile Gly Phe Phe His Gly Ser 
        595                 600                 605             


Gly Lys Arg Leu Pro Gly Trp Asp Asn Phe Phe Val Ala Lys Lys Glu 
    610                 615                 620                 


Asn Arg Trp Leu Met Asn Gly Leu His Lys Ser Phe Ser Asp Leu Ala 
625                 630                 635                 640 


Val His Arg Gly Phe Tyr Val Phe Glu Val Met Pro His Arg Thr Ser 
                645                 650                 655     


Ile Thr Cys Pro Ala Cys Gly His Cys Asp Ser Glu Asn Arg Asp Gly 
            660                 665                 670         


Glu Ala Phe Val Cys Leu Ser Cys Lys Arg Thr Tyr His Ala Asp Leu 
        675                 680                 685             


Asp Val Ala Thr His Asn Leu Thr Gln Val Ala Gly Thr Gly Leu Pro 
    690                 695                 700                 


Met Pro Glu Arg Glu His Pro Gly Gly Thr Lys Lys Pro Gly Gly Ser 
705                 710                 715                 720 


Arg Lys Pro Glu Ser Pro Gln Thr His Ala Pro Ile Leu His Arg Thr 
                725                 730                 735     


Asp Tyr Ser Glu Ser Ala Asp Arg Leu Gly Ser 
            740                 745         


<210> 195
<211> 733
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 195
Gln Ala Val Ile Lys Tyr Leu Ser Asp Lys Gly Ala Val Asp Pro Pro 
1               5                   10                  15      


Asp Phe Arg Pro Pro Ala Lys Cys Asn Ile Ile Ala Gln Ser Arg Pro 
            20                  25                  30          


Phe Asp Glu Trp Pro Ile Cys Lys Ala Ser Met Ala Ile Gln Gln His 
        35                  40                  45              


Ile Tyr Gly Leu Thr Lys Asn Glu Phe Asp Glu Ser Ser Pro Gly Thr 
    50                  55                  60                  


Ser Ser Ala Ser His Glu Gln Trp Phe Ala Lys Thr Gly Val Asp Thr 
65                  70                  75                  80  


His Gly Phe Thr His Val Gln Gly Leu Asn Leu Ile Phe Gln His Ala 
                85                  90                  95      


Lys Lys Arg Tyr Glu Gly Val Ile Lys Lys Val Glu Asn Tyr Asn Glu 
            100                 105                 110         


Lys Glu Arg Lys Lys Phe Glu Gly Ile Asn Glu Arg Arg Ser Lys Glu 
        115                 120                 125             


Gly Met Pro Leu Leu Glu Pro Arg Leu Arg Thr Ala Phe Gly Asp Asp 
    130                 135                 140                 


Gly Lys Phe Ala Glu Lys Pro Gly Val Asn Pro Ser Ile Tyr Leu Tyr 
145                 150                 155                 160 


Gln Gln Thr Ser Pro Arg Pro Tyr Asp Lys Thr Lys His Pro Tyr Val 
                165                 170                 175     


His Ala Pro Phe Glu Leu Lys Glu Ile Thr Thr Ile Pro Thr Gln Asp 
            180                 185                 190         


Asp Arg Leu Lys Ile Pro Phe Gly Ala Pro Gly His Val Pro Glu Lys 
        195                 200                 205             


His Arg Ser Gln Leu Ser Met Ala Lys His Lys Arg Arg Arg Ala Trp 
    210                 215                 220                 


Tyr Ala Leu Ser Gln Asn Lys Pro Arg Pro Pro Lys Asp Gly Ser Lys 
225                 230                 235                 240 


Gly Arg Arg Ser Val Arg Asp Leu Ala Asp Leu Lys Ala Ala Ser Leu 
                245                 250                 255     


Ala Asp Ala Ile Pro Leu Val Ser Arg Val Gly Phe Asp Trp Val Val 
            260                 265                 270         


Ile Asp Gly Arg Gly Leu Leu Arg Asn Leu Arg Trp Arg Lys Leu Ala 
        275                 280                 285             


His Glu Gly Met Thr Val Glu Glu Met Leu Gly Phe Phe Ser Gly Asp 
    290                 295                 300                 


Pro Val Ile Asp Pro Arg Arg Asn Val Ala Thr Phe Ile Tyr Lys Ala 
305                 310                 315                 320 


Glu His Ala Thr Val Lys Ser Arg Lys Pro Ile Gly Gly Ala Lys Arg 
                325                 330                 335     


Ala Arg Glu Glu Leu Leu Lys Ala Thr Ala Ser Ser Asp Gly Val Ile 
            340                 345                 350         


Arg Gln Val Gly Leu Ile Ser Val Asp Leu Gly Gln Thr Asn Pro Val 
        355                 360                 365             


Ala Tyr Glu Ile Ser Arg Met His Gln Ala Asn Gly Glu Leu Val Ala 
    370                 375                 380                 


Glu His Leu Glu Tyr Gly Leu Leu Asn Asp Glu Gln Val Asn Ser Ile 
385                 390                 395                 400 


Gln Arg Tyr Arg Ala Ala Trp Asp Ser Met Asn Glu Ser Phe Arg Gln 
                405                 410                 415     


Lys Ala Ile Glu Ser Leu Ser Met Glu Ala Gln Asp Glu Ile Met Gln 
            420                 425                 430         


Ala Ser Thr Gly Ala Ala Lys Arg Thr Arg Glu Ala Val Leu Thr Met 
        435                 440                 445             


Phe Gly Pro Asn Ala Thr Leu Pro Trp Ser Arg Met Ser Ser Asn Thr 
    450                 455                 460                 


Thr Cys Ile Ser Asp Ala Leu Ile Glu Val Gly Lys Glu Glu Glu Thr 
465                 470                 475                 480 


Asn Phe Val Thr Ser Asn Gly Pro Arg Lys Arg Thr Asp Ala Gln Trp 
                485                 490                 495     


Ala Ala Tyr Leu Arg Pro Arg Val Asn Pro Glu Thr Arg Ala Leu Leu 
            500                 505                 510         


Asn Gln Ala Val Trp Asp Leu Met Lys Arg Ser Asp Glu Tyr Glu Arg 
        515                 520                 525             


Leu Ser Lys Arg Lys Leu Glu Met Ala Arg Gln Cys Val Asn Phe Val 
    530                 535                 540                 


Val Ala Arg Ala Glu Lys Leu Thr Gln Cys Asn Asn Ile Gly Ile Val 
545                 550                 555                 560 


Leu Glu Asn Leu Val Val Arg Asn Phe His Gly Ser Gly Arg Arg Glu 
                565                 570                 575     


Ser Gly Trp Glu Gly Phe Phe Glu Pro Lys Arg Glu Asn Arg Trp Phe 
            580                 585                 590         


Met Gln Val Leu His Lys Ala Phe Ser Asp Leu Ala Gln His Arg Gly 
        595                 600                 605             


Val Met Val Phe Glu Val His Pro Ala Tyr Ser Ser Gln Thr Cys Pro 
    610                 615                 620                 


Ala Cys Arg Tyr Val Asp Pro Lys Asn Arg Ser Ser Glu Asp Arg Glu 
625                 630                 635                 640 


Arg Phe Lys Cys Leu Lys Cys Gly Arg Ser Phe Asn Ala Asp Arg Glu 
                645                 650                 655     


Val Ala Thr Phe Asn Ile Arg Glu Ile Ala Arg Thr Gly Val Gly Leu 
            660                 665                 670         


Pro Lys Pro Asp Cys Glu Arg Ser Arg Asp Val Gln Thr Pro Gly Thr 
        675                 680                 685             


Ala Arg Lys Ser Gly Arg Ser Leu Lys Ser Gln Asp Asn Leu Ser Glu 
    690                 695                 700                 


Pro Lys Arg Val Leu Gln Ser Lys Thr Arg Lys Lys Ile Thr Ser Thr 
705                 710                 715                 720 


Glu Thr Gln Asn Glu Pro Leu Ala Thr Asp Leu Lys Thr 
                725                 730             


<210> 196
<211> 702
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 196
Met Ile Lys Glu Gln Ser Glu Leu Ser Lys Leu Ile Glu Lys Tyr Tyr 
1               5                   10                  15      


Pro Gly Lys Lys Phe Tyr Ser Asn Asp Leu Lys Gln Ala Gly Lys His 
            20                  25                  30          


Leu Lys Lys Ser Glu His Leu Thr Ala Lys Glu Ser Glu Glu Leu Thr 
        35                  40                  45              


Val Glu Phe Leu Lys Ser Cys Lys Glu Lys Leu Tyr Asp Phe Arg Pro 
    50                  55                  60                  


Pro Ala Lys Ala Leu Ile Ile Ser Thr Ser Arg Pro Phe Glu Glu Trp 
65                  70                  75                  80  


Pro Ile Tyr Lys Ala Ser Glu Ser Ile Gln Lys Tyr Ile Tyr Ser Leu 
                85                  90                  95      


Thr Lys Glu Glu Leu Glu Lys Tyr Asn Ile Ser Thr Asp Lys Thr Ser 
            100                 105                 110         


Gln Glu Asn Phe Phe Lys Glu Ser Leu Ile Asp Asn Tyr Gly Phe Ala 
        115                 120                 125             


Asn Val Ser Gly Leu Asn Leu Ile Phe Gln His Thr Lys Ala Ile Tyr 
    130                 135                 140                 


Asp Gly Val Leu Lys Lys Val Asn Asn Arg Asn Asn Lys Ile Leu Lys 
145                 150                 155                 160 


Lys Tyr Lys Arg Lys Ile Glu Glu Gly Ile Glu Ile Asp Ser Pro Glu 
                165                 170                 175     


Leu Glu Lys Ala Ile Asp Glu Ser Gly His Phe Ile Asn Pro Pro Gly 
            180                 185                 190         


Ile Asn Lys Asn Ile Tyr Cys Tyr Gln Gln Val Ser Pro Thr Ile Phe 
        195                 200                 205             


Asn Ser Phe Lys Glu Thr Lys Ile Ile Cys Pro Phe Asn Tyr Lys Arg 
    210                 215                 220                 


Asn Pro Asn Asp Ile Ile Gln Lys Gly Val Ile Asp Arg Leu Ala Ile 
225                 230                 235                 240 


Pro Phe Gly Glu Pro Gly Tyr Ile Pro Asp His Gln Arg Asp Lys Val 
                245                 250                 255     


Asn Lys His Lys Lys Arg Ile Arg Lys Tyr Tyr Lys Asn Asn Glu Asn 
            260                 265                 270         


Lys Asn Lys Asp Ala Ile Leu Ala Lys Ile Asn Ile Gly Glu Asp Trp 
        275                 280                 285             


Val Leu Phe Asp Leu Arg Gly Leu Leu Arg Asn Ala Tyr Trp Arg Lys 
    290                 295                 300                 


Leu Ile Pro Lys Gln Gly Ile Thr Pro Gln Gln Leu Leu Asp Met Phe 
305                 310                 315                 320 


Ser Gly Asp Pro Val Ile Asp Pro Ile Lys Asn Asn Ile Thr Phe Ile 
                325                 330                 335     


Tyr Lys Glu Ser Ile Ile Pro Ile His Ser Glu Ser Ile Ile Lys Thr 
            340                 345                 350         


Lys Lys Ser Lys Glu Leu Leu Glu Lys Leu Thr Lys Asp Glu Gln Ile 
        355                 360                 365             


Ala Leu Val Ser Ile Asp Leu Gly Gln Thr Asn Pro Val Ala Ala Arg 
    370                 375                 380                 


Phe Ser Arg Leu Ser Ser Asp Leu Lys Pro Glu His Val Ser Ser Ser 
385                 390                 395                 400 


Phe Leu Pro Asp Glu Leu Lys Asn Glu Ile Cys Arg Tyr Arg Glu Lys 
                405                 410                 415     


Ser Asp Leu Leu Glu Ile Glu Ile Lys Asn Lys Ala Ile Lys Met Leu 
            420                 425                 430         


Ser Gln Glu Gln Gln Asp Glu Ile Lys Leu Val Asn Asp Ile Ser Ser 
        435                 440                 445             


Glu Glu Leu Lys Asn Ser Val Cys Lys Lys Tyr Asn Ile Asp Asn Ser 
    450                 455                 460                 


Lys Ile Pro Trp Asp Lys Met Asn Gly Phe Thr Thr Phe Ile Ala Asp 
465                 470                 475                 480 


Glu Phe Ile Asn Asn Gly Gly Asp Lys Ser Leu Val Tyr Phe Thr Ala 
                485                 490                 495     


Lys Asp Lys Lys Ser Lys Lys Glu Lys Leu Val Lys Leu Ser Asp Lys 
            500                 505                 510         


Lys Ile Ala Asn Ser Phe Lys Pro Lys Ile Ser Lys Glu Thr Arg Glu 
        515                 520                 525             


Ile Leu Asn Lys Ile Thr Trp Asp Glu Lys Ile Ser Ser Asn Glu Tyr 
    530                 535                 540                 


Lys Lys Leu Ser Lys Arg Lys Leu Glu Phe Ala Arg Arg Ala Thr Asn 
545                 550                 555                 560 


Tyr Leu Ile Asn Gln Ala Lys Lys Ala Thr Arg Leu Asn Asn Val Val 
                565                 570                 575     


Leu Val Val Glu Asp Leu Asn Ser Lys Phe Phe His Gly Ser Gly Lys 
            580                 585                 590         


Arg Glu Asp Gly Trp Asp Asn Phe Phe Ile Pro Lys Lys Glu Asn Arg 
        595                 600                 605             


Trp Phe Ile Gln Ala Leu His Lys Ser Leu Thr Asp Val Ser Ile His 
    610                 615                 620                 


Arg Gly Ile Asn Val Ile Glu Val Arg Pro Glu Arg Thr Ser Ile Thr 
625                 630                 635                 640 


Cys Pro Lys Cys Gly Cys Cys Asp Lys Glu Asn Arg Lys Gly Glu Asp 
                645                 650                 655     


Phe Lys Cys Ile Lys Cys Asp Ser Val Tyr His Ala Asp Leu Glu Val 
            660                 665                 670         


Ala Thr Phe Asn Ile Glu Lys Val Ala Ile Thr Gly Glu Ser Met Pro 
        675                 680                 685             


Lys Pro Asp Cys Glu Arg Leu Gly Gly Glu Glu Ser Ile Gly 
    690                 695                 700         


<210> 197
<211> 661
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 197
Val Ala Phe Leu Asp Gly Lys Glu Val Asp Glu Pro Tyr Thr Leu Gln 
1               5                   10                  15      


Pro Pro Ala Lys Cys His Ile Leu Ala Val Ser Arg Pro Ile Glu Glu 
            20                  25                  30          


Trp Pro Ile Ala Arg Val Thr Met Ala Val Gln Glu His Val Tyr Ala 
        35                  40                  45              


Leu Pro Val His Glu Val Glu Lys Ser Arg Pro Glu Thr Thr Glu Gly 
    50                  55                  60                  


Ser Arg Ser Ala Trp Phe Lys Asn Ser Gly Val Ser Asn His Gly Val 
65                  70                  75                  80  


Thr His Ala Gln Thr Leu Asn Ala Ile Leu Lys Asn Ala Tyr Asn Val 
                85                  90                  95      


Tyr Asn Gly Val Ile Lys Lys Val Glu Asn Arg Asn Ala Lys Lys Arg 
            100                 105                 110         


Asp Ser Leu Ala Ala Lys Asn Lys Ser Arg Glu Arg Lys Gly Leu Pro 
        115                 120                 125             


His Phe Lys Ala Asp Pro Pro Glu Leu Ala Thr Asp Glu Gln Gly Tyr 
    130                 135                 140                 


Leu Leu Gln Pro Pro Ser Pro Asn Ser Ser Val Tyr Leu Val Gln Gln 
145                 150                 155                 160 


His Leu Arg Thr Pro Gln Ile Asp Leu Pro Ser Gly Tyr Thr Gly Pro 
                165                 170                 175     


Val Val Asp Pro Arg Ser Pro Ile Pro Ser Leu Ile Pro Ile Asp Arg 
            180                 185                 190         


Leu Ala Ile Pro Pro Gly Gln Pro Gly Tyr Val Pro Leu His Asp Arg 
        195                 200                 205             


Glu Lys Leu Thr Ser Asn Lys His Arg Arg Met Lys Leu Pro Lys Ser 
    210                 215                 220                 


Leu Arg Ala Gln Gly Ala Leu Pro Val Cys Phe Arg Val Phe Asp Asp 
225                 230                 235                 240 


Trp Ala Val Val Asp Gly Arg Gly Leu Leu Arg His Ala Gln Tyr Arg 
                245                 250                 255     


Arg Leu Ala Pro Lys Asn Val Ser Ile Ala Glu Leu Leu Glu Leu Tyr 
            260                 265                 270         


Thr Gly Asp Pro Val Ile Asp Ile Lys Arg Asn Leu Met Thr Phe Arg 
        275                 280                 285             


Phe Ala Glu Ala Val Val Glu Val Thr Ala Arg Lys Ile Val Glu Lys 
    290                 295                 300                 


Tyr His Asn Lys Tyr Leu Leu Lys Leu Thr Glu Pro Lys Gly Lys Pro 
305                 310                 315                 320 


Val Arg Glu Ile Gly Leu Val Ser Ile Asp Leu Asn Val Gln Arg Leu 
                325                 330                 335     


Ile Ala Leu Ala Ile Tyr Arg Val His Gln Thr Gly Glu Ser Gln Leu 
            340                 345                 350         


Ala Leu Ser Pro Cys Leu His Arg Glu Ile Leu Pro Ala Lys Gly Leu 
        355                 360                 365             


Gly Asp Phe Asp Lys Tyr Lys Ser Lys Phe Asn Gln Leu Thr Glu Glu 
    370                 375                 380                 


Ile Leu Thr Ala Ala Val Gln Thr Leu Thr Ser Ala Gln Gln Glu Glu 
385                 390                 395                 400 


Tyr Gln Arg Tyr Val Glu Glu Ser Ser His Glu Ala Lys Ala Asp Leu 
                405                 410                 415     


Cys Leu Lys Tyr Ser Ile Thr Pro His Glu Leu Ala Trp Asp Lys Met 
            420                 425                 430         


Thr Ser Ser Thr Gln Tyr Ile Ser Arg Trp Leu Arg Asp His Gly Trp 
        435                 440                 445             


Asn Ala Ser Asp Phe Thr Gln Ile Thr Lys Gly Arg Lys Lys Val Glu 
    450                 455                 460                 


Arg Leu Trp Ser Asp Ser Arg Trp Ala Gln Glu Leu Lys Pro Lys Leu 
465                 470                 475                 480 


Ser Asn Glu Thr Arg Arg Lys Leu Glu Asp Ala Lys His Asp Leu Gln 
                485                 490                 495     


Arg Ala Asn Pro Glu Trp Gln Arg Leu Ala Lys Arg Lys Gln Glu Tyr 
            500                 505                 510         


Ser Arg His Leu Ala Asn Thr Val Leu Ser Met Ala Arg Glu Tyr Thr 
        515                 520                 525             


Ala Cys Glu Thr Val Val Ile Ala Ile Glu Asn Leu Pro Met Lys Gly 
    530                 535                 540                 


Gly Phe Val Asp Gly Asn Gly Ser Arg Glu Ser Gly Trp Asp Asn Phe 
545                 550                 555                 560 


Phe Thr His Lys Lys Glu Asn Arg Trp Met Ile Lys Asp Ile His Lys 
                565                 570                 575     


Ala Leu Ser Asp Leu Ala Pro Asn Arg Gly Val His Val Leu Glu Val 
            580                 585                 590         


Asn Pro Gln Tyr Thr Ser Gln Thr Cys Pro Glu Cys Gly His Arg Asp 
        595                 600                 605             


Lys Ala Asn Arg Asp Pro Ile Gln Arg Glu Arg Phe Cys Cys Thr His 
    610                 615                 620                 


Cys Gly Ala Gln Arg His Ala Asp Leu Glu Val Ala Thr His Asn Ile 
625                 630                 635                 640 


Ala Met Val Ala Thr Thr Gly Lys Ser Leu Thr Gly Lys Ser Leu Ala 
                645                 650                 655     


Pro Gln Arg Leu Gln 
            660     


<210> 198
<211> 531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 198
Leu Glu Ile Pro Glu Gly Glu Pro Gly His Val Pro Trp Phe Gln Arg 
1               5                   10                  15      


Met Asp Ile Pro Glu Gly Gln Ile Gly His Val Asn Lys Ile Gln Arg 
            20                  25                  30          


Phe Asn Phe Val His Gly Lys Asn Ser Gly Lys Val Lys Phe Ser Asp 
        35                  40                  45              


Lys Thr Gly Arg Val Lys Arg Tyr His His Ser Lys Tyr Lys Asp Ala 
    50                  55                  60                  


Thr Lys Pro Tyr Lys Phe Leu Glu Glu Ser Lys Lys Val Ser Ala Leu 
65                  70                  75                  80  


Asp Ser Ile Leu Ala Ile Ile Thr Ile Gly Asp Asp Trp Val Val Phe 
                85                  90                  95      


Asp Ile Arg Gly Leu Tyr Arg Asn Val Phe Tyr Arg Glu Leu Ala Gln 
            100                 105                 110         


Lys Gly Leu Thr Ala Val Gln Leu Leu Asp Leu Phe Thr Gly Asp Pro 
        115                 120                 125             


Val Ile Asp Pro Lys Lys Gly Ile Ile Thr Phe Ser Tyr Lys Glu Gly 
    130                 135                 140                 


Val Val Pro Val Phe Ser Gln Lys Ile Val Ser Arg Phe Lys Ser Arg 
145                 150                 155                 160 


Asp Thr Leu Glu Lys Leu Thr Ser Gln Gly Pro Val Ala Leu Leu Ser 
                165                 170                 175     


Val Asp Leu Gly Gln Asn Glu Pro Val Ala Ala Arg Val Cys Ser Leu 
            180                 185                 190         


Lys Asn Ile Asn Asp Lys Ile Ala Leu Asp Asn Ser Cys Arg Ile Pro 
        195                 200                 205             


Phe Leu Asp Asp Tyr Lys Lys Gln Ile Lys Asp Tyr Arg Asp Ser Leu 
    210                 215                 220                 


Asp Glu Leu Glu Ile Lys Ile Arg Leu Glu Ala Ile Asn Ser Leu Asp 
225                 230                 235                 240 


Val Asn Gln Gln Val Glu Ile Arg Asp Leu Asp Val Phe Ser Ala Asp 
                245                 250                 255     


Arg Ala Lys Ala Ser Thr Val Asp Met Phe Asp Ile Asp Pro Asn Leu 
            260                 265                 270         


Ile Ser Trp Asp Ser Met Ser Asp Ala Arg Phe Ser Thr Gln Ile Ser 
        275                 280                 285             


Asp Leu Tyr Leu Lys Asn Gly Gly Asp Glu Ser Arg Val Tyr Phe Glu 
    290                 295                 300                 


Ile Asn Asn Lys Arg Ile Lys Arg Ser Asp Tyr Asn Ile Ser Gln Leu 
305                 310                 315                 320 


Val Arg Pro Lys Leu Ser Asp Ser Thr Arg Lys Asn Leu Asn Asp Ser 
                325                 330                 335     


Ile Trp Lys Leu Lys Arg Thr Ser Glu Glu Tyr Leu Lys Leu Ser Lys 
            340                 345                 350         


Arg Lys Leu Glu Leu Ser Arg Ala Val Val Asn Tyr Thr Ile Arg Gln 
        355                 360                 365             


Ser Lys Leu Leu Ser Gly Ile Asn Asp Ile Val Ile Ile Leu Glu Asp 
    370                 375                 380                 


Leu Asp Val Lys Lys Lys Phe Asn Gly Arg Gly Ile Arg Asp Ile Gly 
385                 390                 395                 400 


Trp Asp Asn Phe Phe Ser Ser Arg Lys Glu Asn Arg Trp Phe Ile Pro 
                405                 410                 415     


Ala Phe His Lys Ser Phe Ser Glu Leu Ser Ser Asn Arg Gly Leu Cys 
            420                 425                 430         


Val Ile Glu Val Asn Pro Ala Trp Thr Ser Ala Thr Cys Pro Asp Cys 
        435                 440                 445             


Gly Phe Cys Ser Lys Glu Asn Arg Asp Gly Ile Asn Phe Thr Cys Arg 
    450                 455                 460                 


Lys Cys Gly Val Ser Tyr His Ala Asp Ile Asp Val Ala Thr Leu Asn 
465                 470                 475                 480 


Ile Ala Arg Val Ala Val Leu Gly Lys Pro Met Ser Gly Pro Ala Asp 
                485                 490                 495     


Arg Glu Arg Leu Gly Gly Thr Lys Lys Pro Arg Val Ala Arg Ser Arg 
            500                 505                 510         


Lys Asp Met Lys Arg Lys Asp Ile Ser Asn Gly Thr Val Glu Val Met 
        515                 520                 525             


Val Thr Ala 
    530     


<210> 199
<211> 479
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 199
Ile Pro Ser Phe Gly Tyr Leu Asp Arg Leu Lys Ile Ala Lys Gly Gln 
1               5                   10                  15      


Pro Gly Tyr Ile Pro Glu Trp Gln Arg Glu Thr Ile Asn Pro Ser Lys 
            20                  25                  30          


Lys Val Arg Arg Tyr Trp Ala Thr Asn His Glu Lys Ile Arg Asn Ala 
        35                  40                  45              


Ile Pro Leu Val Val Phe Ile Gly Asp Asp Trp Val Ile Ile Asp Gly 
    50                  55                  60                  


Arg Gly Leu Leu Arg Asp Ala Arg Arg Arg Lys Leu Ala Asp Lys Asn 
65                  70                  75                  80  


Thr Thr Ile Glu Gln Leu Leu Glu Met Val Ser Asn Asp Pro Val Ile 
                85                  90                  95      


Asp Ser Thr Arg Gly Ile Ala Thr Leu Ser Tyr Val Glu Gly Val Val 
            100                 105                 110         


Pro Val Arg Ser Phe Ile Pro Ile Gly Glu Lys Lys Gly Arg Glu Tyr 
        115                 120                 125             


Leu Glu Lys Ser Thr Gln Lys Glu Ser Val Thr Leu Leu Ser Val Asp 
    130                 135                 140                 


Ile Gly Gln Ile Asn Pro Val Ser Cys Gly Val Tyr Lys Val Ser Asn 
145                 150                 155                 160 


Gly Cys Ser Lys Ile Asp Phe Leu Asp Lys Phe Phe Leu Asp Lys Lys 
                165                 170                 175     


His Leu Asp Ala Ile Gln Lys Tyr Arg Thr Leu Gln Asp Ser Leu Glu 
            180                 185                 190         


Ala Ser Ile Val Asn Glu Ala Leu Asp Glu Ile Asp Pro Ser Phe Lys 
        195                 200                 205             


Lys Glu Tyr Gln Asn Ile Asn Ser Gln Thr Ser Asn Asp Val Lys Lys 
    210                 215                 220                 


Ser Leu Cys Thr Glu Tyr Asn Ile Asp Pro Glu Ala Ile Ser Trp Gln 
225                 230                 235                 240 


Asp Ile Thr Ala His Ser Thr Leu Ile Ser Asp Tyr Leu Ile Asp Asn 
                245                 250                 255     


Asn Ile Thr Asn Asp Val Tyr Arg Thr Val Asn Lys Ala Lys Tyr Lys 
            260                 265                 270         


Thr Asn Asp Phe Gly Trp Tyr Lys Lys Phe Ser Ala Lys Leu Ser Lys 
        275                 280                 285             


Glu Ala Arg Glu Ala Leu Asn Glu Lys Ile Trp Glu Leu Lys Ile Ala 
    290                 295                 300                 


Ser Ser Lys Tyr Lys Lys Leu Ser Val Arg Lys Lys Glu Ile Ala Arg 
305                 310                 315                 320 


Thr Ile Ala Asn Asp Cys Val Lys Arg Ala Glu Thr Tyr Gly Asp Asn 
                325                 330                 335     


Val Val Val Ala Met Glu Ser Leu Thr Lys Asn Asn Lys Val Met Ser 
            340                 345                 350         


Gly Arg Gly Lys Arg Asp Pro Gly Trp His Asn Leu Gly Gln Ala Lys 
        355                 360                 365             


Val Glu Asn Arg Trp Phe Ile Gln Ala Ile Ser Ser Ala Phe Glu Asp 
    370                 375                 380                 


Lys Ala Thr His His Gly Thr Pro Val Leu Lys Val Asn Pro Ala Tyr 
385                 390                 395                 400 


Thr Ser Gln Thr Cys Pro Ser Cys Gly His Cys Ser Lys Asp Asn Arg 
                405                 410                 415     


Ser Ser Lys Asp Arg Thr Ile Phe Val Cys Lys Ser Cys Gly Glu Lys 
            420                 425                 430         


Phe Asn Ala Asp Leu Asp Val Ala Thr Tyr Asn Ile Ala His Val Ala 
        435                 440                 445             


Phe Ser Gly Lys Lys Leu Ser Pro Pro Ser Glu Lys Ser Ser Ala Thr 
    450                 455                 460                 


Lys Lys Pro Arg Ser Ala Arg Lys Ser Lys Lys Ser Arg Lys Ser 
465                 470                 475                 


<210> 200
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 200
Ser Pro Ile Glu Lys Leu Leu Asn Gly Leu Leu Val Lys Ile Thr Phe 
1               5                   10                  15      


Gly Asn Asp Trp Ile Ile Cys Asp Ala Arg Gly Leu Leu Asp Asn Val 
            20                  25                  30          


Gln Lys Gly Ile Ile His Lys Ser Tyr Phe Thr Asn Lys Ser Ser Leu 
        35                  40                  45              


Val Asp Leu Ile Asp Leu Phe Thr Cys Asn Pro Ile Val Asn Tyr Lys 
    50                  55                  60                  


Asn Asn Val Val Thr Phe Cys Tyr Lys Glu Gly Val Val Asp Val Lys 
65                  70                  75                  80  


Ser Phe Thr Pro Ile Lys Ser Gly Pro Lys Thr Gln Glu Asn Leu Ile 
                85                  90                  95      


Lys Lys Leu Lys Tyr Ser Arg Phe Gln Asn Glu Lys Asp Ala Cys Val 
            100                 105                 110         


Leu Gly Val Gly Val Asp Val Gly Val Thr Asn Pro Phe Ala Ile Asn 
        115                 120                 125             


Gly Phe Lys Met Pro Val Asp Glu Ser Ser Glu Trp Val Met Leu Asn 
    130                 135                 140                 


Glu Pro Leu Phe Thr Ile Glu Thr Ser Gln Ala Phe Arg Glu Glu Ile 
145                 150                 155                 160 


Met Ala Tyr Gln Gln Arg Thr Asp Glu Met Asn Asp Gln Phe Asn Gln 
                165                 170                 175     


Gln Ser Ile Asp Leu Leu Pro Pro Glu Tyr Lys Val Glu Phe Asp Asn 
            180                 185                 190         


Leu Pro Glu Asp Ile Asn Glu Val Ala Lys Tyr Asn Leu Leu His Thr 
        195                 200                 205             


Leu Asn Ile Pro Asn Asn Phe Leu Trp Asp Lys Met Ser Asn Thr Thr 
    210                 215                 220                 


Gln Phe Ile Ser Asp Tyr Leu Ile Gln Ile Gly Arg Gly Thr Glu Thr 
225                 230                 235                 240 


Glu Lys Thr Ile Thr Thr Lys Lys Gly Lys Glu Lys Ile Leu Thr Ile 
                245                 250                 255     


Arg Asp Val Asn Trp Phe Asn Thr Phe Lys Pro Lys Ile Ser Glu Glu 
            260                 265                 270         


Thr Gly Lys Ala Arg Thr Glu Ile Lys Arg Asp Leu Gln Lys Asn Ser 
        275                 280                 285             


Asp Gln Phe Gln Lys Leu Ala Lys Ser Arg Glu Gln Ser Cys Arg Thr 
    290                 295                 300                 


Trp Val Asn Asn Val Thr Glu Glu Ala Lys Ile Lys Ser Gly Cys Pro 
305                 310                 315                 320 


Leu Ile Ile Phe Val Ile Glu Ala Leu Val Lys Asp Asn Arg Val Phe 
                325                 330                 335     


Ser Gly Lys Gly His Arg Ala Ile Gly Trp His Asn Phe Gly Lys Gln 
            340                 345                 350         


Lys Asn Glu Arg Arg Trp Trp Val Gln Ala Ile His Lys Ala Phe Gln 
        355                 360                 365             


Glu Gln Gly Val Asn His Gly Tyr Pro Val Ile Leu Cys Pro Pro Gln 
    370                 375                 380                 


Tyr Thr Ser Gln Thr Cys Pro Lys Cys Asn His Val Asp Arg Asp Asn 
385                 390                 395                 400 


Arg Ser Gly Glu Lys Phe Lys Cys Leu Lys Tyr Gly Trp Ile Gly Asn 
                405                 410                 415     


Ala Asp Leu Asp Val Gly Ala Tyr Asn Ile Ala Arg Val Ala Ile Thr 
            420                 425                 430         


Gly Lys Ala Leu Ser Lys Pro Leu Glu Gln Lys Lys Ile Lys Lys Ala 
        435                 440                 445             


Lys Asn Lys Thr 
    450         


<210> 201
<211> 425
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 201
Leu Leu Asp Asn Val Gln Lys Gly Ile Ile His Lys Ser Tyr Phe Thr 
1               5                   10                  15      


Asn Lys Ser Ser Leu Val Asp Leu Ile Asp Leu Phe Thr Cys Asn Pro 
            20                  25                  30          


Ile Val Asn Tyr Lys Asn Asn Val Val Thr Phe Cys Tyr Lys Glu Gly 
        35                  40                  45              


Val Val Asp Val Lys Ser Phe Thr Pro Ile Lys Ser Gly Pro Lys Thr 
    50                  55                  60                  


Gln Glu Asn Leu Ile Lys Lys Leu Lys Tyr Ser Arg Phe Gln Asn Glu 
65                  70                  75                  80  


Lys Asp Ala Cys Val Leu Gly Val Gly Val Asp Val Gly Val Thr Asn 
                85                  90                  95      


Pro Phe Ala Ile Asn Gly Phe Lys Met Pro Val Asp Glu Ser Ser Glu 
            100                 105                 110         


Trp Val Met Leu Asn Glu Pro Leu Phe Thr Ile Glu Thr Ser Gln Ala 
        115                 120                 125             


Phe Arg Glu Glu Ile Met Ala Tyr Gln Gln Arg Thr Asp Glu Met Asn 
    130                 135                 140                 


Asp Gln Phe Asn Gln Gln Ser Ile Asp Leu Leu Pro Pro Glu Tyr Lys 
145                 150                 155                 160 


Val Glu Phe Asp Asn Leu Pro Glu Asp Ile Asn Glu Val Ala Lys Tyr 
                165                 170                 175     


Asn Leu Leu His Thr Leu Asn Ile Pro Asn Asn Phe Leu Trp Asp Lys 
            180                 185                 190         


Met Ser Asn Thr Thr Gln Phe Ile Ser Asp Tyr Leu Ile Gln Ile Gly 
        195                 200                 205             


Arg Gly Thr Glu Thr Glu Lys Thr Ile Thr Thr Lys Lys Gly Lys Glu 
    210                 215                 220                 


Lys Ile Leu Thr Ile Arg Asp Val Asn Trp Phe Asn Thr Phe Lys Pro 
225                 230                 235                 240 


Lys Ile Ser Glu Glu Thr Gly Lys Ala Arg Thr Glu Ile Lys Arg Asp 
                245                 250                 255     


Leu Gln Lys Asn Ser Asp Gln Phe Gln Lys Leu Ala Lys Ser Arg Glu 
            260                 265                 270         


Gln Ser Cys Arg Thr Trp Val Asn Asn Val Thr Glu Glu Ala Lys Ile 
        275                 280                 285             


Lys Ser Gly Cys Pro Leu Ile Ile Phe Val Ile Glu Ala Leu Val Lys 
    290                 295                 300                 


Asp Asn Arg Val Phe Ser Gly Lys Gly His Arg Ala Ile Gly Trp His 
305                 310                 315                 320 


Asn Phe Gly Lys Gln Lys Asn Glu Arg Arg Trp Trp Val Gln Ala Ile 
                325                 330                 335     


His Lys Ala Phe Gln Glu Gln Gly Val Asn His Gly Tyr Pro Val Ile 
            340                 345                 350         


Leu Cys Pro Pro Gln Tyr Thr Ser Gln Thr Cys Pro Lys Cys Asn His 
        355                 360                 365             


Val Asp Arg Asp Asn Arg Ser Gly Glu Lys Phe Lys Cys Leu Lys Tyr 
    370                 375                 380                 


Gly Trp Ile Gly Asn Ala Asp Leu Asp Val Gly Ala Tyr Asn Ile Ala 
385                 390                 395                 400 


Arg Val Ala Ile Thr Gly Lys Ala Leu Ser Lys Pro Leu Glu Gln Lys 
                405                 410                 415     


Lys Ile Lys Lys Ala Lys Asn Lys Thr 
            420                 425 


<210> 202
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 202
Met Ile Lys Pro Thr Val Ser Gln Phe Leu Thr Pro Gly Phe Lys Leu 
1               5                   10                  15      


Ile Arg Asn His Ser Arg Thr Ala Gly Leu Lys Leu Lys Asn Glu Gly 
            20                  25                  30          


Glu Glu Ala Cys Lys Lys Phe Val Arg Glu Asn Glu Ile Pro Lys Asp 
        35                  40                  45              


Glu Cys Pro Asn Phe Gln Gly Gly Pro Ala Ile Ala Asn Ile Ile Ala 
    50                  55                  60                  


Lys Ser Arg Glu Phe Thr Glu Trp Glu Ile Tyr Gln Ser Ser Leu Ala 
65                  70                  75                  80  


Ile Gln Glu Val Ile Phe Thr Leu Pro Lys Asp Lys Leu Pro Glu Pro 
                85                  90                  95      


Ile Leu Lys Glu Glu Trp Arg Ala Gln Trp Leu Ser Glu His Gly Leu 
            100                 105                 110         


Asp Thr Val Pro Tyr Lys Glu Ala Ala Gly Leu Asn Leu Ile Ile Lys 
        115                 120                 125             


Asn Ala Val Asn Thr Tyr Lys Gly Val Gln Val Lys Val Asp Asn Lys 
    130                 135                 140                 


Asn Lys Asn Asn Leu Ala Lys Ile Asn Arg Lys Asn Glu Ile Ala Lys 
145                 150                 155                 160 


Leu Asn Gly Glu Gln Glu Ile Ser Phe Glu Glu Ile Lys Ala Phe Asp 
                165                 170                 175     


Asp Lys Gly Tyr Leu Leu Gln Lys Pro Ser Pro Asn Lys Ser Ile Tyr 
            180                 185                 190         


Cys Tyr Gln Ser Val Ser Pro Lys Pro Phe Ile Thr Ser Lys Tyr His 
        195                 200                 205             


Asn Val Asn Leu Pro Glu Glu Tyr Ile Gly Tyr Tyr Arg Lys Ser Asn 
    210                 215                 220                 


Glu Pro Ile Val Ser Pro Tyr Gln Phe Asp Arg Leu Arg Ile Pro Ile 
225                 230                 235                 240 


Gly Glu Pro Gly Tyr Val Pro Lys Trp Gln Tyr Thr Phe Leu Ser Lys 
                245                 250                 255     


Lys Glu Asn Lys Arg Arg Lys Leu Ser Lys Arg Ile Lys Asn Val Ser 
            260                 265                 270         


Pro Ile Leu Gly Ile Ile Cys Ile Lys Lys Asp Trp Cys Val Phe Asp 
        275                 280                 285             


Met Arg Gly Leu Leu Arg Thr Asn His Trp Lys Lys Tyr His Lys Pro 
    290                 295                 300                 


Thr Asp Ser Ile Asn Asp Leu Phe Asp Tyr Phe Thr Gly Asp Pro Val 
305                 310                 315                 320 


Ile Asp Thr Lys Ala Asn Val Val Arg Phe Arg Tyr Lys Met Glu Asn 
                325                 330                 335     


Gly Ile Val Asn Tyr Lys Pro Val Arg Glu Lys Lys Gly Lys Glu Leu 
            340                 345                 350         


Leu Glu Asn Ile Cys Asp Gln Asn Gly Ser Cys Lys Leu Ala Thr Val 
        355                 360                 365             


Asp Val Gly Gln Asn Asn Pro Val Ala Ile Gly Leu Phe Glu Leu Lys 
    370                 375                 380                 


Lys Val Asn Gly Glu Leu Thr Lys Thr Leu Ile Ser Arg His Pro Thr 
385                 390                 395                 400 


Pro Ile Asp Phe Cys Asn Lys Ile Thr Ala Tyr Arg Glu Arg Tyr Asp 
                405                 410                 415     


Lys Leu Glu Ser Ser Ile Lys Leu Asp Ala Ile Lys Gln Leu Thr Ser 
            420                 425                 430         


Glu Gln Lys Ile Glu Val Asp Asn Tyr Asn Asn Asn Phe Thr Pro Gln 
        435                 440                 445             


Asn Thr Lys Gln Ile Val Cys Ser Lys Leu Asn Ile Asn Pro Asn Asp 
    450                 455                 460                 


Leu Pro Trp Asp Lys Met Ile Ser Gly Thr His Phe Ile Ser Glu Lys 
465                 470                 475                 480 


Ala Gln Val Ser Asn Lys Ser Glu Ile Tyr Phe Thr Ser Thr Asp Lys 
                485                 490                 495     


Gly Lys Thr Lys Asp Val Met Lys Ser Asp Tyr Lys Trp Phe Gln Asp 
            500                 505                 510         


Tyr Lys Pro Lys Leu Ser Lys Glu Val Arg Asp Ala Leu Ser Asp Ile 
        515                 520                 525             


Glu Trp Arg Leu Arg Arg Glu Ser Leu Glu Phe Asn Lys Leu Ser Lys 
    530                 535                 540                 


Ser Arg Glu Gln Asp Ala Arg Gln Leu Ala Asn Trp Ile Ser Ser Met 
545                 550                 555                 560 


Cys Asp Val Ile Gly Ile Glu Asn Leu Val Lys Lys Asn Asn Phe Phe 
                565                 570                 575     


Gly Gly Ser Gly Lys Arg Glu Pro Gly Trp Asp Asn Phe Tyr Lys Pro 
            580                 585                 590         


Lys Lys Glu Asn Arg Trp Trp Ile Asn Ala Ile His Lys Ala Leu Thr 
        595                 600                 605             


Glu Leu Ser Gln Asn Lys Gly Lys Arg Val Ile Leu Leu Pro Ala Met 
    610                 615                 620                 


Arg Thr Ser Ile Thr Cys Pro Lys Cys Lys Tyr Cys Asp Ser Lys Asn 
625                 630                 635                 640 


Arg Asn Gly Glu Lys Phe Asn Cys Leu Lys Cys Gly Ile Glu Leu Asn 
                645                 650                 655     


Ala Asp Ile Asp Val Ala Thr Glu Asn Leu Ala Thr Val Ala Ile Thr 
            660                 665                 670         


Ala Gln Ser Met Pro Lys Pro Thr Cys Glu Arg Ser Gly Asp Ala Lys 
        675                 680                 685             


Lys Pro Val Arg Ala Arg Lys Ala Lys Ala Pro Glu Phe His Asp Lys 
    690                 695                 700                 


Leu Ala Pro Ser Tyr Thr Val Val Leu Arg Glu Ala Val Lys Arg Pro 
705                 710                 715                 720 


Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Glu Phe 
                725                 730                 735 


<210> 203
<211> 1120
<212> PRT
<213> Listeria seeligeri

<400> 203
Met Trp Ile Ser Ile Lys Thr Leu Ile His His Leu Gly Val Leu Phe 
1               5                   10                  15      


Phe Cys Asp Tyr Met Tyr Asn Arg Arg Glu Lys Lys Ile Ile Glu Val 
            20                  25                  30          


Lys Thr Met Arg Ile Thr Lys Val Glu Val Asp Arg Lys Lys Val Leu 
        35                  40                  45              


Ile Ser Arg Asp Lys Asn Gly Gly Lys Leu Val Tyr Glu Asn Glu Met 
    50                  55                  60                  


Gln Asp Asn Thr Glu Gln Ile Met His His Lys Lys Ser Ser Phe Tyr 
65                  70                  75                  80  


Lys Ser Val Val Asn Lys Thr Ile Cys Arg Pro Glu Gln Lys Gln Met 
                85                  90                  95      


Lys Lys Leu Val His Gly Leu Leu Gln Glu Asn Ser Gln Glu Lys Ile 
            100                 105                 110         


Lys Val Ser Asp Val Thr Lys Leu Asn Ile Ser Asn Phe Leu Asn His 
        115                 120                 125             


Arg Phe Lys Lys Ser Leu Tyr Tyr Phe Pro Glu Asn Ser Pro Asp Lys 
    130                 135                 140                 


Ser Glu Glu Tyr Arg Ile Glu Ile Asn Leu Ser Gln Leu Leu Glu Asp 
145                 150                 155                 160 


Ser Leu Lys Lys Gln Gln Gly Thr Phe Ile Cys Trp Glu Ser Phe Ser 
                165                 170                 175     


Lys Asp Met Glu Leu Tyr Ile Asn Trp Ala Glu Asn Tyr Ile Ser Ser 
            180                 185                 190         


Lys Thr Lys Leu Ile Lys Lys Ser Ile Arg Asn Asn Arg Ile Gln Ser 
        195                 200                 205             


Thr Glu Ser Arg Ser Gly Gln Leu Met Asp Arg Tyr Met Lys Asp Ile 
    210                 215                 220                 


Leu Asn Lys Asn Lys Pro Phe Asp Ile Gln Ser Val Ser Glu Lys Tyr 
225                 230                 235                 240 


Gln Leu Glu Lys Leu Thr Ser Ala Leu Lys Ala Thr Phe Lys Glu Ala 
                245                 250                 255     


Lys Lys Asn Asp Lys Glu Ile Asn Tyr Lys Leu Lys Ser Thr Leu Gln 
            260                 265                 270         


Asn His Glu Arg Gln Ile Ile Glu Glu Leu Lys Glu Asn Ser Glu Leu 
        275                 280                 285             


Asn Gln Phe Asn Ile Glu Ile Arg Lys His Leu Glu Thr Tyr Phe Pro 
    290                 295                 300                 


Ile Lys Lys Thr Asn Arg Lys Val Gly Asp Ile Arg Asn Leu Glu Ile 
305                 310                 315                 320 


Gly Glu Ile Gln Lys Ile Val Asn His Arg Leu Lys Asn Lys Ile Val 
                325                 330                 335     


Gln Arg Ile Leu Gln Glu Gly Lys Leu Ala Ser Tyr Glu Ile Glu Ser 
            340                 345                 350         


Thr Val Asn Ser Asn Ser Leu Gln Lys Ile Lys Ile Glu Glu Ala Phe 
        355                 360                 365             


Ala Leu Lys Phe Ile Asn Ala Cys Leu Phe Ala Ser Asn Asn Leu Arg 
    370                 375                 380                 


Asn Met Val Tyr Pro Val Cys Lys Lys Asp Ile Leu Met Ile Gly Glu 
385                 390                 395                 400 


Phe Lys Asn Ser Phe Lys Glu Ile Lys His Lys Lys Phe Ile Arg Gln 
                405                 410                 415     


Trp Ser Gln Phe Phe Ser Gln Glu Ile Thr Val Asp Asp Ile Glu Leu 
            420                 425                 430         


Ala Ser Trp Gly Leu Arg Gly Ala Ile Ala Pro Ile Arg Asn Glu Ile 
        435                 440                 445             


Ile His Leu Lys Lys His Ser Trp Lys Lys Phe Phe Asn Asn Pro Thr 
    450                 455                 460                 


Phe Lys Val Lys Lys Ser Lys Ile Ile Asn Gly Lys Thr Lys Asp Val 
465                 470                 475                 480 


Thr Ser Glu Phe Leu Tyr Lys Glu Thr Leu Phe Lys Asp Tyr Phe Tyr 
                485                 490                 495     


Ser Glu Leu Asp Ser Val Pro Glu Leu Ile Ile Asn Lys Met Glu Ser 
            500                 505                 510         


Ser Lys Ile Leu Asp Tyr Tyr Ser Ser Asp Gln Leu Asn Gln Val Phe 
        515                 520                 525             


Thr Ile Pro Asn Phe Glu Leu Ser Leu Leu Thr Ser Ala Val Pro Phe 
    530                 535                 540                 


Ala Pro Ser Phe Lys Arg Val Tyr Leu Lys Gly Phe Asp Tyr Gln Asn 
545                 550                 555                 560 


Gln Asp Glu Ala Gln Pro Asp Tyr Asn Leu Lys Leu Asn Ile Tyr Asn 
                565                 570                 575     


Glu Lys Ala Phe Asn Ser Glu Ala Phe Gln Ala Gln Tyr Ser Leu Phe 
            580                 585                 590         


Lys Met Val Tyr Tyr Gln Val Phe Leu Pro Gln Phe Thr Thr Asn Asn 
        595                 600                 605             


Asp Leu Phe Lys Ser Ser Val Asp Phe Ile Leu Thr Leu Asn Lys Glu 
    610                 615                 620                 


Arg Lys Gly Tyr Ala Lys Ala Phe Gln Asp Ile Arg Lys Met Asn Lys 
625                 630                 635                 640 


Asp Glu Lys Pro Ser Glu Tyr Met Ser Tyr Ile Gln Ser Gln Leu Met 
                645                 650                 655     


Leu Tyr Gln Lys Lys Gln Glu Glu Lys Glu Lys Ile Asn His Phe Glu 
            660                 665                 670         


Lys Phe Ile Asn Gln Val Phe Ile Lys Gly Phe Asn Ser Phe Ile Glu 
        675                 680                 685             


Lys Asn Arg Leu Thr Tyr Ile Cys His Pro Thr Lys Asn Thr Val Pro 
    690                 695                 700                 


Glu Asn Asp Asn Ile Glu Ile Pro Phe His Thr Asp Met Asp Asp Ser 
705                 710                 715                 720 


Asn Ile Ala Phe Trp Leu Met Cys Lys Leu Leu Asp Ala Lys Gln Leu 
                725                 730                 735     


Ser Glu Leu Arg Asn Glu Met Ile Lys Phe Ser Cys Ser Leu Gln Ser 
            740                 745                 750         


Thr Glu Glu Ile Ser Thr Phe Thr Lys Ala Arg Glu Val Ile Gly Leu 
        755                 760                 765             


Ala Leu Leu Asn Gly Glu Lys Gly Cys Asn Asp Trp Lys Glu Leu Phe 
    770                 775                 780                 


Asp Asp Lys Glu Ala Trp Lys Lys Asn Met Ser Leu Tyr Val Ser Glu 
785                 790                 795                 800 


Glu Leu Leu Gln Ser Leu Pro Tyr Thr Gln Glu Asp Gly Gln Thr Pro 
                805                 810                 815     


Val Ile Asn Arg Ser Ile Asp Leu Val Lys Lys Tyr Gly Thr Glu Thr 
            820                 825                 830         


Ile Leu Glu Lys Leu Phe Ser Ser Ser Asp Asp Tyr Lys Val Ser Ala 
        835                 840                 845             


Lys Asp Ile Ala Lys Leu His Glu Tyr Asp Val Thr Glu Lys Ile Ala 
    850                 855                 860                 


Gln Gln Glu Ser Leu His Lys Gln Trp Ile Glu Lys Pro Gly Leu Ala 
865                 870                 875                 880 


Arg Asp Ser Ala Trp Thr Lys Lys Tyr Gln Asn Val Ile Asn Asp Ile 
                885                 890                 895     


Ser Asn Tyr Gln Trp Ala Lys Thr Lys Val Glu Leu Thr Gln Val Arg 
            900                 905                 910         


His Leu His Gln Leu Thr Ile Asp Leu Leu Ser Arg Leu Ala Gly Tyr 
        915                 920                 925             


Met Ser Ile Ala Asp Arg Asp Phe Gln Phe Ser Ser Asn Tyr Ile Leu 
    930                 935                 940                 


Glu Arg Glu Asn Ser Glu Tyr Arg Val Thr Ser Trp Ile Leu Leu Ser 
945                 950                 955                 960 


Glu Asn Lys Asn Lys Asn Lys Tyr Asn Asp Tyr Glu Leu Tyr Asn Leu 
                965                 970                 975     


Lys Asn Ala Ser Ile Lys Val Ser Ser Lys Asn Asp Pro Gln Leu Lys 
            980                 985                 990         


Val Asp Leu Lys Gln Leu Arg Leu  Thr Leu Glu Tyr Leu  Glu Leu Phe 
        995                 1000                 1005             


Asp Asn  Arg Leu Lys Glu Lys  Arg Asn Asn Ile Ser  His Phe Asn 
    1010                 1015                 1020             


Tyr Leu  Asn Gly Gln Leu Gly  Asn Ser Ile Leu Glu  Leu Phe Asp 
    1025                 1030                 1035             


Asp Ala  Arg Asp Val Leu Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1040                 1045                 1050             


Val Ser  Lys Ser Leu Lys Glu  Ile Leu Ser Ser His  Gly Met Glu 
    1055                 1060                 1065             


Val Thr  Phe Lys Pro Leu Tyr  Gln Thr Asn His His  Leu Lys Ile 
    1070                 1075                 1080             


Asp Lys  Leu Gln Pro Lys Lys  Ile His His Leu Gly  Glu Lys Ser 
    1085                 1090                 1095             


Thr Val  Ser Ser Asn Gln Val  Ser Asn Glu Tyr Cys  Gln Leu Val 
    1100                 1105                 1110             


Arg Thr  Leu Leu Thr Met Lys  
    1115                 1120 


<210> 204
<211> 1159
<212> PRT
<213> Leptotrichia buccalis

<400> 204
Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Ser Thr Glu Thr Lys Glu Asn Gln Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Leu Glu Ser Asp Val Arg Asp Lys Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Asn Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Glu Ile Glu Asn Leu Thr Lys Leu Glu Lys Tyr Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys Asn Ile 
        275                 280                 285             


Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn Glu Asn 
            420                 425                 430         


Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala Pro Ser 
                485                 490                 495     


Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr 
        515                 520                 525             


Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr 
                565                 570                 575     


Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln 
            580                 585                 590         


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe 
        595                 600                 605             


Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile Ile Glu 
    610                 615                 620                 


Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu 
625                 630                 635                 640 


Gln Lys Phe Glu Asp Ile Gln Glu Lys Ile Pro Lys Glu Tyr Leu Ala 
                645                 650                 655     


Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu 
            660                 665                 670         


Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
        675                 680                 685             


Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile 
    690                 695                 700                 


Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu 
705                 710                 715                 720 


Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Lys Ile 
                725                 730                 735     


Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile 
            740                 745                 750         


Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu 
        755                 760                 765             


Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr 
    770                 775                 780                 


Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu Leu Ile 
785                 790                 795                 800 


Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu 
                805                 810                 815     


Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Val 
            820                 825                 830         


Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe 
        835                 840                 845             


Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly Tyr 
865                 870                 875                 880 


Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn Glu 
                885                 890                 895     


Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr Ala 
            900                 905                 910         


Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser Tyr 
        915                 920                 925             


Lys Gln Ala Ile Glu Asn Ile Glu Glu Tyr Thr His Leu Lys Asn Lys 
    930                 935                 940                 


Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg Ile 
945                 950                 955                 960 


Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile 
            980                 985                 990         


Phe Asn Phe Glu Asn Lys Lys Asn  Val Lys Tyr Lys Gly  Gly Gln Ile 
        995                 1000                 1005             


Val Glu  Lys Tyr Ile Lys Phe  Tyr Lys Glu Leu His  Gln Asn Asp 
    1010                 1015                 1020             


Glu Val  Lys Ile Asn Lys Tyr  Ser Ser Ala Asn Ile  Lys Val Leu 
    1025                 1030                 1035             


Lys Gln  Glu Lys Lys Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Ile Pro His Ala  Glu Ile Ser Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Glu Asn  Leu Arg Lys Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Met Lys Ser Val Val  Asp Ile Leu Lys Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Val Ala  Thr Phe Lys Ile Gly  Ala Asp Lys Lys Ile  Gly Ile Gln 
    1100                 1105                 1110             


Thr Leu  Glu Ser Glu Lys Ile  Val His Leu Lys Asn  Leu Lys Lys 
    1115                 1120                 1125             


Lys Lys  Leu Met Thr Asp Arg  Asn Ser Glu Glu Leu  Cys Lys Leu 
    1130                 1135                 1140             


Val Lys  Ile Met Phe Glu Tyr  Lys Met Glu Glu Lys  Lys Ser Glu 
    1145                 1150                 1155             


Asn 
    


<210> 205
<211> 1389
<212> PRT
<213> Leptotrichia shahii

<400> 205
Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Arg Asp Lys 
1               5                   10                  15      


Lys Asp Phe Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Lys Tyr Ile Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Ile Leu Lys Glu Phe Thr Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Lys Glu Gly Ile Ile Arg Ile Glu Asn Asn 
                85                  90                  95      


Asp Asp Phe Leu Glu Thr Glu Glu Val Val Leu Tyr Ile Glu Ala Tyr 
            100                 105                 110         


Gly Lys Ser Glu Lys Leu Lys Ala Leu Gly Ile Thr Lys Lys Lys Ile 
        115                 120                 125             


Ile Asp Glu Ala Ile Arg Gln Gly Ile Thr Lys Asp Asp Lys Lys Ile 
    130                 135                 140                 


Glu Ile Lys Arg Gln Glu Asn Glu Glu Glu Ile Glu Ile Asp Ile Arg 
145                 150                 155                 160 


Asp Glu Tyr Thr Asn Lys Thr Leu Asn Asp Cys Ser Ile Ile Leu Arg 
                165                 170                 175     


Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys Lys Ser Ile Tyr Glu Ile 
            180                 185                 190         


Phe Lys Asn Ile Asn Met Ser Leu Tyr Lys Ile Ile Glu Lys Ile Ile 
        195                 200                 205             


Glu Asn Glu Thr Glu Lys Val Phe Glu Asn Arg Tyr Tyr Glu Glu His 
    210                 215                 220                 


Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Ile Asp Val Ile Leu Thr 
225                 230                 235                 240 


Asn Phe Met Glu Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu Ile Leu 
                245                 250                 255     


Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser 
            260                 265                 270         


Lys Asn Lys Lys Met Leu Val Glu Lys Ile Leu Asn Ile Asn Val Asp 
        275                 280                 285             


Leu Thr Val Glu Asp Ile Ala Asp Phe Val Ile Lys Glu Leu Glu Phe 
    290                 295                 300                 


Trp Asn Ile Thr Lys Arg Ile Glu Lys Val Lys Lys Val Asn Asn Glu 
305                 310                 315                 320 


Phe Leu Glu Lys Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu 
                325                 330                 335     


Leu Asp Lys His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp 
            340                 345                 350         


Lys Ile Val Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys 
        355                 360                 365             


Glu Lys Ile Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Ile 
    370                 375                 380                 


Lys Lys Leu Glu Lys Glu Leu Lys Lys Gly Asn Cys Asp Thr Glu Ile 
385                 390                 395                 400 


Phe Gly Ile Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys 
                405                 410                 415     


Phe Ser Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
            420                 425                 430         


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu Gln Lys 
        435                 440                 445             


Val Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn 
    450                 455                 460                 


Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr 
465                 470                 475                 480 


Leu Glu His Ile Met Tyr Leu Gly Lys Leu Arg His Asn Asp Ile Asp 
                485                 490                 495     


Met Thr Thr Val Asn Thr Asp Asp Phe Ser Arg Leu His Ala Lys Glu 
            500                 505                 510         


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
        515                 520                 525             


Leu Asn Lys Ile Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile 
    530                 535                 540                 


Asp Phe Phe Gly Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys 
545                 550                 555                 560 


Ile Leu Asn Ser Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp 
                565                 570                 575     


Asn Lys Asn Asn Ile Thr Asn Asn Phe Ile Arg Lys Phe Thr Lys Ile 
            580                 585                 590         


Gly Thr Asn Glu Arg Asn Arg Ile Leu His Ala Ile Ser Lys Glu Arg 
        595                 600                 605             


Asp Leu Gln Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile 
    610                 615                 620                 


Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu 
625                 630                 635                 640 


Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp 
                645                 650                 655     


Ile Lys Ile Ser Glu Glu Asn Asn Asn Asp Ile Lys Tyr Leu Pro Ser 
            660                 665                 670         


Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro 
        675                 680                 685             


Lys Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu Asn 
    690                 695                 700                 


Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu 
705                 710                 715                 720 


Asp Asp Leu Glu Glu Asn Glu Ser Lys Asn Ile Phe Leu Gln Glu Leu 
                725                 730                 735     


Lys Lys Thr Leu Gly Asn Ile Asp Glu Ile Asp Glu Asn Ile Ile Glu 
            740                 745                 750         


Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys 
        755                 760                 765             


Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile Gly Tyr 
    770                 775                 780                 


Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe Lys Met 
785                 790                 795                 800 


Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn Lys 
                805                 810                 815     


Thr Tyr Glu Arg Ile Thr Val Lys Thr Ser Asp Lys Thr Ile Val Ile 
            820                 825                 830         


Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser 
        835                 840                 845             


Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val 
    850                 855                 860                 


Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile Asp Ile Leu Asp Glu 
865                 870                 875                 880 


Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp 
                885                 890                 895     


Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys 
            900                 905                 910         


Asp Phe Asp Asp Phe Lys Ile Gln Thr Lys Lys Glu Ile Phe Asn Asn 
        915                 920                 925             


Tyr Tyr Glu Asp Ile Lys Asn Asn Ile Leu Thr Glu Phe Lys Asp Asp 
    930                 935                 940                 


Ile Asn Gly Cys Asp Val Leu Glu Lys Lys Leu Glu Lys Ile Val Ile 
945                 950                 955                 960 


Phe Asp Asp Glu Thr Lys Phe Glu Ile Asp Lys Lys Ser Asn Ile Leu 
                965                 970                 975     


Gln Asp Glu Gln Arg Lys Leu Ser Asn Ile Asn Lys Lys Asp Leu Lys 
            980                 985                 990         


Lys Lys Val Asp Gln Tyr Ile Lys  Asp Lys Asp Gln Glu  Ile Lys Ser 
        995                 1000                 1005             


Lys Ile  Leu Cys Arg Ile Ile  Phe Asn Ser Asp Phe  Leu Lys Lys 
    1010                 1015                 1020             


Tyr Lys  Lys Glu Ile Asp Asn  Leu Ile Glu Asp Met  Glu Ser Glu 
    1025                 1030                 1035             


Asn Glu  Asn Lys Phe Gln Glu  Ile Tyr Tyr Pro Lys  Glu Arg Lys 
    1040                 1045                 1050             


Asn Glu  Leu Tyr Ile Tyr Lys  Lys Asn Leu Phe Leu  Asn Ile Gly 
    1055                 1060                 1065             


Asn Pro  Asn Phe Asp Lys Ile  Tyr Gly Leu Ile Ser  Asn Asp Ile 
    1070                 1075                 1080             


Lys Met  Ala Asp Ala Lys Phe  Leu Phe Asn Ile Asp  Gly Lys Asn 
    1085                 1090                 1095             


Ile Arg  Lys Asn Lys Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn 
    1100                 1105                 1110             


Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Lys Glu Tyr  Lys Glu Lys 
    1115                 1120                 1125             


Tyr Ile  Lys Lys Leu Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn 
    1130                 1135                 1140             


Ile Gln  Asn Lys Asn Tyr Lys  Ser Phe Glu Lys Asp  Tyr Asn Arg 
    1145                 1150                 1155             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1160                 1165                 1170             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1175                 1180                 1185             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1190                 1195                 1200             


Asn Gly  Leu Arg Glu Leu Gly  Ile Ile Lys Leu Ser  Gly Tyr Asn 
    1205                 1210                 1215             


Thr Gly  Ile Ser Arg Ala Tyr  Pro Lys Arg Asn Gly  Ser Asp Gly 
    1220                 1225                 1230             


Phe Tyr  Thr Thr Thr Ala Tyr  Tyr Lys Phe Phe Asp  Glu Glu Ser 
    1235                 1240                 1245             


Tyr Lys  Lys Phe Glu Lys Ile  Cys Tyr Gly Phe Gly  Ile Asp Leu 
    1250                 1255                 1260             


Ser Glu  Asn Ser Glu Ile Asn  Lys Pro Glu Asn Glu  Ser Ile Arg 
    1265                 1270                 1275             


Asn Tyr  Ile Ser His Phe Tyr  Ile Val Arg Asn Pro  Phe Ala Asp 
    1280                 1285                 1290             


Tyr Ser  Ile Ala Glu Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser 
    1295                 1300                 1305             


Tyr Ser  Thr Arg Tyr Asn Asn  Ser Thr Tyr Ala Ser  Val Phe Glu 
    1310                 1315                 1320             


Val Phe  Lys Lys Asp Val Asn  Leu Asp Tyr Asp Glu  Leu Lys Lys 
    1325                 1330                 1335             


Lys Phe  Lys Leu Ile Gly Asn  Asn Asp Ile Leu Glu  Arg Leu Met 
    1340                 1345                 1350             


Lys Pro  Lys Lys Val Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser 
    1355                 1360                 1365             


Asp Tyr  Ile Lys Asn Leu Ile  Ile Glu Leu Leu Thr  Lys Ile Glu 
    1370                 1375                 1380             


Asn Thr  Asn Asp Thr Leu 
    1385                 


<210> 206
<211> 1285
<212> PRT
<213> Rhodobacter capsulatus

<400> 206
Met Gln Ile Gly Lys Val Gln Gly Arg Thr Ile Ser Glu Phe Gly Asp 
1               5                   10                  15      


Pro Ala Gly Gly Leu Lys Arg Lys Ile Ser Thr Asp Gly Lys Asn Arg 
            20                  25                  30          


Lys Glu Leu Pro Ala His Leu Ser Ser Asp Pro Lys Ala Leu Ile Gly 
        35                  40                  45              


Gln Trp Ile Ser Gly Ile Asp Lys Ile Tyr Arg Lys Pro Asp Ser Arg 
    50                  55                  60                  


Lys Ser Asp Gly Lys Ala Ile His Ser Pro Thr Pro Ser Lys Met Gln 
65                  70                  75                  80  


Phe Asp Ala Arg Asp Asp Leu Gly Glu Ala Phe Trp Lys Leu Val Ser 
                85                  90                  95      


Glu Ala Gly Leu Ala Gln Asp Ser Asp Tyr Asp Gln Phe Lys Arg Arg 
            100                 105                 110         


Leu His Pro Tyr Gly Asp Lys Phe Gln Pro Ala Asp Ser Gly Ala Lys 
        115                 120                 125             


Leu Lys Phe Glu Ala Asp Pro Pro Glu Pro Gln Ala Phe His Gly Arg 
    130                 135                 140                 


Trp Tyr Gly Ala Met Ser Lys Arg Gly Asn Asp Ala Lys Glu Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Tyr Glu His Leu His Val Asp Glu Lys Arg Ile Asp Gly 
                165                 170                 175     


Gln Pro Lys Arg Asn Pro Lys Thr Asp Lys Phe Ala Pro Gly Leu Val 
            180                 185                 190         


Val Ala Arg Ala Leu Gly Ile Glu Ser Ser Val Leu Pro Arg Gly Met 
        195                 200                 205             


Ala Arg Leu Ala Arg Asn Trp Gly Glu Glu Glu Ile Gln Thr Tyr Phe 
    210                 215                 220                 


Val Val Asp Val Ala Ala Ser Val Lys Glu Val Ala Lys Ala Ala Val 
225                 230                 235                 240 


Ser Ala Ala Gln Ala Phe Asp Pro Pro Arg Gln Val Ser Gly Arg Ser 
                245                 250                 255     


Leu Ser Pro Lys Val Gly Phe Ala Leu Ala Glu His Leu Glu Arg Val 
            260                 265                 270         


Thr Gly Ser Lys Arg Cys Ser Phe Asp Pro Ala Ala Gly Pro Ser Val 
        275                 280                 285             


Leu Ala Leu His Asp Glu Val Lys Lys Thr Tyr Lys Arg Leu Cys Ala 
    290                 295                 300                 


Arg Gly Lys Asn Ala Ala Arg Ala Phe Pro Ala Asp Lys Thr Glu Leu 
305                 310                 315                 320 


Leu Ala Leu Met Arg His Thr His Glu Asn Arg Val Arg Asn Gln Met 
                325                 330                 335     


Val Arg Met Gly Arg Val Ser Glu Tyr Arg Gly Gln Gln Ala Gly Asp 
            340                 345                 350         


Leu Ala Gln Ser His Tyr Trp Thr Ser Ala Gly Gln Thr Glu Ile Lys 
        355                 360                 365             


Glu Ser Glu Ile Phe Val Arg Leu Trp Val Gly Ala Phe Ala Leu Ala 
    370                 375                 380                 


Gly Arg Ser Met Lys Ala Trp Ile Asp Pro Met Gly Lys Ile Val Asn 
385                 390                 395                 400 


Thr Glu Lys Asn Asp Arg Asp Leu Thr Ala Ala Val Asn Ile Arg Gln 
                405                 410                 415     


Val Ile Ser Asn Lys Glu Met Val Ala Glu Ala Met Ala Arg Arg Gly 
            420                 425                 430         


Ile Tyr Phe Gly Glu Thr Pro Glu Leu Asp Arg Leu Gly Ala Glu Gly 
        435                 440                 445             


Asn Glu Gly Phe Val Phe Ala Leu Leu Arg Tyr Leu Arg Gly Cys Arg 
    450                 455                 460                 


Asn Gln Thr Phe His Leu Gly Ala Arg Ala Gly Phe Leu Lys Glu Ile 
465                 470                 475                 480 


Arg Lys Glu Leu Glu Lys Thr Arg Trp Gly Lys Ala Lys Glu Ala Glu 
                485                 490                 495     


His Val Val Leu Thr Asp Lys Thr Val Ala Ala Ile Arg Ala Ile Ile 
            500                 505                 510         


Asp Asn Asp Ala Lys Ala Leu Gly Ala Arg Leu Leu Ala Asp Leu Ser 
        515                 520                 525             


Gly Ala Phe Val Ala His Tyr Ala Ser Lys Glu His Phe Ser Thr Leu 
    530                 535                 540                 


Tyr Ser Glu Ile Val Lys Ala Val Lys Asp Ala Pro Glu Val Ser Ser 
545                 550                 555                 560 


Gly Leu Pro Arg Leu Lys Leu Leu Leu Lys Arg Ala Asp Gly Val Arg 
                565                 570                 575     


Gly Tyr Val His Gly Leu Arg Asp Thr Arg Lys His Ala Phe Ala Thr 
            580                 585                 590         


Lys Leu Pro Pro Pro Pro Ala Pro Arg Glu Leu Asp Asp Pro Ala Thr 
        595                 600                 605             


Lys Ala Arg Tyr Ile Ala Leu Leu Arg Leu Tyr Asp Gly Pro Phe Arg 
    610                 615                 620                 


Ala Tyr Ala Ser Gly Ile Thr Gly Thr Ala Leu Ala Gly Pro Ala Ala 
625                 630                 635                 640 


Arg Ala Lys Glu Ala Ala Thr Ala Leu Ala Gln Ser Val Asn Val Thr 
                645                 650                 655     


Lys Ala Tyr Ser Asp Val Met Glu Gly Arg Ser Ser Arg Leu Arg Pro 
            660                 665                 670         


Pro Asn Asp Gly Glu Thr Leu Arg Glu Tyr Leu Ser Ala Leu Thr Gly 
        675                 680                 685             


Glu Thr Ala Thr Glu Phe Arg Val Gln Ile Gly Tyr Glu Ser Asp Ser 
    690                 695                 700                 


Glu Asn Ala Arg Lys Gln Ala Glu Phe Ile Glu Asn Tyr Arg Arg Asp 
705                 710                 715                 720 


Met Leu Ala Phe Met Phe Glu Asp Tyr Ile Arg Ala Lys Gly Phe Asp 
                725                 730                 735     


Trp Ile Leu Lys Ile Glu Pro Gly Ala Thr Ala Met Thr Arg Ala Pro 
            740                 745                 750         


Val Leu Pro Glu Pro Ile Asp Thr Arg Gly Gln Tyr Glu His Trp Gln 
        755                 760                 765             


Ala Ala Leu Tyr Leu Val Met His Phe Val Pro Ala Ser Asp Val Ser 
    770                 775                 780                 


Asn Leu Leu His Gln Leu Arg Lys Trp Glu Ala Leu Gln Gly Lys Tyr 
785                 790                 795                 800 


Glu Leu Val Gln Asp Gly Asp Ala Thr Asp Gln Ala Asp Ala Arg Arg 
                805                 810                 815     


Glu Ala Leu Asp Leu Val Lys Arg Phe Arg Asp Val Leu Val Leu Phe 
            820                 825                 830         


Leu Lys Thr Gly Glu Ala Arg Phe Glu Gly Arg Ala Ala Pro Phe Asp 
        835                 840                 845             


Leu Lys Pro Phe Arg Ala Leu Phe Ala Asn Pro Ala Thr Phe Asp Arg 
    850                 855                 860                 


Leu Phe Met Ala Thr Pro Thr Thr Ala Arg Pro Ala Glu Asp Asp Pro 
865                 870                 875                 880 


Glu Gly Asp Gly Ala Ser Glu Pro Glu Leu Arg Val Ala Arg Thr Leu 
                885                 890                 895     


Arg Gly Leu Arg Gln Ile Ala Arg Tyr Asn His Met Ala Val Leu Ser 
            900                 905                 910         


Asp Leu Phe Ala Lys His Lys Val Arg Asp Glu Glu Val Ala Arg Leu 
        915                 920                 925             


Ala Glu Ile Glu Asp Glu Thr Gln Glu Lys Ser Gln Ile Val Ala Ala 
    930                 935                 940                 


Gln Glu Leu Arg Thr Asp Leu His Asp Lys Val Met Lys Cys His Pro 
945                 950                 955                 960 


Lys Thr Ile Ser Pro Glu Glu Arg Gln Ser Tyr Ala Ala Ala Ile Lys 
                965                 970                 975     


Thr Ile Glu Glu His Arg Phe Leu Val Gly Arg Val Tyr Leu Gly Asp 
            980                 985                 990         


His Leu Arg Leu His Arg Leu Met  Met Asp Val Ile Gly  Arg Leu Ile 
        995                 1000                 1005             


Asp Tyr  Ala Gly Ala Tyr Glu  Arg Asp Thr Gly Thr  Phe Leu Ile 
    1010                 1015                 1020             


Asn Ala  Ser Lys Gln Leu Gly  Ala Gly Ala Asp Trp  Ala Val Thr 
    1025                 1030                 1035             


Ile Ala  Gly Ala Ala Asn Thr  Asp Ala Arg Thr Gln  Thr Arg Lys 
    1040                 1045                 1050             


Asp Leu  Ala His Phe Asn Val  Leu Asp Arg Ala Asp  Gly Thr Pro 
    1055                 1060                 1065             


Asp Leu  Thr Ala Leu Val Asn  Arg Ala Arg Glu Met  Met Ala Tyr 
    1070                 1075                 1080             


Asp Arg  Lys Arg Lys Asn Ala  Val Pro Arg Ser Ile  Leu Asp Met 
    1085                 1090                 1095             


Leu Ala  Arg Leu Gly Leu Thr  Leu Lys Trp Gln Met  Lys Asp His 
    1100                 1105                 1110             


Leu Leu  Gln Asp Ala Thr Ile  Thr Gln Ala Ala Ile  Lys His Leu 
    1115                 1120                 1125             


Asp Lys  Val Arg Leu Thr Val  Gly Gly Pro Ala Ala  Val Thr Glu 
    1130                 1135                 1140             


Ala Arg  Phe Ser Gln Asp Tyr  Leu Gln Met Val Ala  Ala Val Phe 
    1145                 1150                 1155             


Asn Gly  Ser Val Gln Asn Pro  Lys Pro Arg Arg Arg  Asp Asp Gly 
    1160                 1165                 1170             


Asp Ala  Trp His Lys Pro Pro  Lys Pro Ala Thr Ala  Gln Ser Gln 
    1175                 1180                 1185             


Pro Asp  Gln Lys Pro Pro Asn  Lys Ala Pro Ser Ala  Gly Ser Arg 
    1190                 1195                 1200             


Leu Pro  Pro Pro Gln Val Gly  Glu Val Tyr Glu Gly  Val Val Val 
    1205                 1210                 1215             


Lys Val  Ile Asp Thr Gly Ser  Leu Gly Phe Leu Ala  Val Glu Gly 
    1220                 1225                 1230             


Val Ala  Gly Asn Ile Gly Leu  His Ile Ser Arg Leu  Arg Arg Ile 
    1235                 1240                 1245             


Arg Glu  Asp Ala Ile Ile Val  Gly Arg Arg Tyr Arg  Phe Arg Val 
    1250                 1255                 1260             


Glu Ile  Tyr Val Pro Pro Lys  Ser Asn Thr Ser Lys  Leu Asn Ala 
    1265                 1270                 1275             


Ala Asp  Leu Val Arg Ile Asp  
    1280                 1285 


<210> 207
<211> 1175
<212> PRT
<213> Carnobacterium gallinarum

<400> 207
Met Arg Ile Thr Lys Val Lys Ile Lys Leu Asp Asn Lys Leu Tyr Gln 
1               5                   10                  15      


Val Thr Met Gln Lys Glu Glu Lys Tyr Gly Thr Leu Lys Leu Asn Glu 
            20                  25                  30          


Glu Ser Arg Lys Ser Thr Ala Glu Ile Leu Arg Leu Lys Lys Ala Ser 
        35                  40                  45              


Phe Asn Lys Ser Phe His Ser Lys Thr Ile Asn Ser Gln Lys Glu Asn 
    50                  55                  60                  


Lys Asn Ala Thr Ile Lys Lys Asn Gly Asp Tyr Ile Ser Gln Ile Phe 
65                  70                  75                  80  


Glu Lys Leu Val Gly Val Asp Thr Asn Lys Asn Ile Arg Lys Pro Lys 
                85                  90                  95      


Met Ser Leu Thr Asp Leu Lys Asp Leu Pro Lys Lys Asp Leu Ala Leu 
            100                 105                 110         


Phe Ile Lys Arg Lys Phe Lys Asn Asp Asp Ile Val Glu Ile Lys Asn 
        115                 120                 125             


Leu Asp Leu Ile Ser Leu Phe Tyr Asn Ala Leu Gln Lys Val Pro Gly 
    130                 135                 140                 


Glu His Phe Thr Asp Glu Ser Trp Ala Asp Phe Cys Gln Glu Met Met 
145                 150                 155                 160 


Pro Tyr Arg Glu Tyr Lys Asn Lys Phe Ile Glu Arg Lys Ile Ile Leu 
                165                 170                 175     


Leu Ala Asn Ser Ile Glu Gln Asn Lys Gly Phe Ser Ile Asn Pro Glu 
            180                 185                 190         


Thr Phe Ser Lys Arg Lys Arg Val Leu His Gln Trp Ala Ile Glu Val 
        195                 200                 205             


Gln Glu Arg Gly Asp Phe Ser Ile Leu Asp Glu Lys Leu Ser Lys Leu 
    210                 215                 220                 


Ala Glu Ile Tyr Asn Phe Lys Lys Met Cys Lys Arg Val Gln Asp Glu 
225                 230                 235                 240 


Leu Asn Asp Leu Glu Lys Ser Met Lys Lys Gly Lys Asn Pro Glu Lys 
                245                 250                 255     


Glu Lys Glu Ala Tyr Lys Lys Gln Lys Asn Phe Lys Ile Lys Thr Ile 
            260                 265                 270         


Trp Lys Asp Tyr Pro Tyr Lys Thr His Ile Gly Leu Ile Glu Lys Ile 
        275                 280                 285             


Lys Glu Asn Glu Glu Leu Asn Gln Phe Asn Ile Glu Ile Gly Lys Tyr 
    290                 295                 300                 


Phe Glu His Tyr Phe Pro Ile Lys Lys Glu Arg Cys Thr Glu Asp Glu 
305                 310                 315                 320 


Pro Tyr Tyr Leu Asn Ser Glu Thr Ile Ala Thr Thr Val Asn Tyr Gln 
                325                 330                 335     


Leu Lys Asn Ala Leu Ile Ser Tyr Leu Met Gln Ile Gly Lys Tyr Lys 
            340                 345                 350         


Gln Phe Gly Leu Glu Asn Gln Val Leu Asp Ser Lys Lys Leu Gln Glu 
        355                 360                 365             


Ile Gly Ile Tyr Glu Gly Phe Gln Thr Lys Phe Met Asp Ala Cys Val 
    370                 375                 380                 


Phe Ala Thr Ser Ser Leu Lys Asn Ile Ile Glu Pro Met Arg Ser Gly 
385                 390                 395                 400 


Asp Ile Leu Gly Lys Arg Glu Phe Lys Glu Ala Ile Ala Thr Ser Ser 
                405                 410                 415     


Phe Val Asn Tyr His His Phe Phe Pro Tyr Phe Pro Phe Glu Leu Lys 
            420                 425                 430         


Gly Met Lys Asp Arg Glu Ser Glu Leu Ile Pro Phe Gly Glu Gln Thr 
        435                 440                 445             


Glu Ala Lys Gln Met Gln Asn Ile Trp Ala Leu Arg Gly Ser Val Gln 
    450                 455                 460                 


Gln Ile Arg Asn Glu Ile Phe His Ser Phe Asp Lys Asn Gln Lys Phe 
465                 470                 475                 480 


Asn Leu Pro Gln Leu Asp Lys Ser Asn Phe Glu Phe Asp Ala Ser Glu 
                485                 490                 495     


Asn Ser Thr Gly Lys Ser Gln Ser Tyr Ile Glu Thr Asp Tyr Lys Phe 
            500                 505                 510         


Leu Phe Glu Ala Glu Lys Asn Gln Leu Glu Gln Phe Phe Ile Glu Arg 
        515                 520                 525             


Ile Lys Ser Ser Gly Ala Leu Glu Tyr Tyr Pro Leu Lys Ser Leu Glu 
    530                 535                 540                 


Lys Leu Phe Ala Lys Lys Glu Met Lys Phe Ser Leu Gly Ser Gln Val 
545                 550                 555                 560 


Val Ala Phe Ala Pro Ser Tyr Lys Lys Leu Val Lys Lys Gly His Ser 
                565                 570                 575     


Tyr Gln Thr Ala Thr Glu Gly Thr Ala Asn Tyr Leu Gly Leu Ser Tyr 
            580                 585                 590         


Tyr Asn Arg Tyr Glu Leu Lys Glu Glu Ser Phe Gln Ala Gln Tyr Tyr 
        595                 600                 605             


Leu Leu Lys Leu Ile Tyr Gln Tyr Val Phe Leu Pro Asn Phe Ser Gln 
    610                 615                 620                 


Gly Asn Ser Pro Ala Phe Arg Glu Thr Val Lys Ala Ile Leu Arg Ile 
625                 630                 635                 640 


Asn Lys Asp Glu Ala Arg Lys Lys Met Lys Lys Asn Lys Lys Phe Leu 
                645                 650                 655     


Arg Lys Tyr Ala Phe Glu Gln Val Arg Glu Met Glu Phe Lys Glu Thr 
            660                 665                 670         


Pro Asp Gln Tyr Met Ser Tyr Leu Gln Ser Glu Met Arg Glu Glu Lys 
        675                 680                 685             


Val Arg Lys Ala Glu Lys Asn Asp Lys Gly Phe Glu Lys Asn Ile Thr 
    690                 695                 700                 


Met Asn Phe Glu Lys Leu Leu Met Gln Ile Phe Val Lys Gly Phe Asp 
705                 710                 715                 720 


Val Phe Leu Thr Thr Phe Ala Gly Lys Glu Leu Leu Leu Ser Ser Glu 
                725                 730                 735     


Glu Lys Val Ile Lys Glu Thr Glu Ile Ser Leu Ser Lys Lys Ile Asn 
            740                 745                 750         


Glu Arg Glu Lys Thr Leu Lys Ala Ser Ile Gln Val Glu His Gln Leu 
        755                 760                 765             


Val Ala Thr Asn Ser Ala Ile Ser Tyr Trp Leu Phe Cys Lys Leu Leu 
    770                 775                 780                 


Asp Ser Arg His Leu Asn Glu Leu Arg Asn Glu Met Ile Lys Phe Lys 
785                 790                 795                 800 


Gln Ser Arg Ile Lys Phe Asn His Thr Gln His Ala Glu Leu Ile Gln 
                805                 810                 815     


Asn Leu Leu Pro Ile Val Glu Leu Thr Ile Leu Ser Asn Asp Tyr Asp 
            820                 825                 830         


Glu Lys Asn Asp Ser Gln Asn Val Asp Val Ser Ala Tyr Phe Glu Asp 
        835                 840                 845             


Lys Ser Leu Tyr Glu Thr Ala Pro Tyr Val Gln Thr Asp Asp Arg Thr 
    850                 855                 860                 


Arg Val Ser Phe Arg Pro Ile Leu Lys Leu Glu Lys Tyr His Thr Lys 
865                 870                 875                 880 


Ser Leu Ile Glu Ala Leu Leu Lys Asp Asn Pro Gln Phe Arg Val Ala 
                885                 890                 895     


Ala Thr Asp Ile Gln Glu Trp Met His Lys Arg Glu Glu Ile Gly Glu 
            900                 905                 910         


Leu Val Glu Lys Arg Lys Asn Leu His Thr Glu Trp Ala Glu Gly Gln 
        915                 920                 925             


Gln Thr Leu Gly Ala Glu Lys Arg Glu Glu Tyr Arg Asp Tyr Cys Lys 
    930                 935                 940                 


Lys Ile Asp Arg Phe Asn Trp Lys Ala Asn Lys Val Thr Leu Thr Tyr 
945                 950                 955                 960 


Leu Ser Gln Leu His Tyr Leu Ile Thr Asp Leu Leu Gly Arg Met Val 
                965                 970                 975     


Gly Phe Ser Ala Leu Phe Glu Arg Asp Leu Val Tyr Phe Ser Arg Ser 
            980                 985                 990         


Phe Ser Glu Leu Gly Gly Glu Thr  Tyr His Ile Ser Asp  Tyr Lys Asn 
        995                 1000                 1005             


Leu Ser  Gly Val Leu Arg Leu  Asn Ala Glu Val Lys  Pro Ile Lys 
    1010                 1015                 1020             


Ile Lys  Asn Ile Lys Val Ile  Asp Asn Glu Glu Asn  Pro Tyr Lys 
    1025                 1030                 1035             


Gly Asn  Glu Pro Glu Val Lys  Pro Phe Leu Asp Arg  Leu His Ala 
    1040                 1045                 1050             


Tyr Leu  Glu Asn Val Ile Gly  Ile Lys Ala Val His  Gly Lys Ile 
    1055                 1060                 1065             


Arg Asn  Gln Thr Ala His Leu  Ser Val Leu Gln Leu  Glu Leu Ser 
    1070                 1075                 1080             


Met Ile  Glu Ser Met Asn Asn  Leu Arg Asp Leu Met  Ala Tyr Asp 
    1085                 1090                 1095             


Arg Lys  Leu Lys Asn Ala Val  Thr Lys Ser Met Ile  Lys Ile Leu 
    1100                 1105                 1110             


Asp Lys  His Gly Met Ile Leu  Lys Leu Lys Ile Asp  Glu Asn His 
    1115                 1120                 1125             


Lys Asn  Phe Glu Ile Glu Ser  Leu Ile Pro Lys Glu  Ile Ile His 
    1130                 1135                 1140             


Leu Lys  Asp Lys Ala Ile Lys  Thr Asn Gln Val Ser  Glu Glu Tyr 
    1145                 1150                 1155             


Cys Gln  Leu Val Leu Ala Leu  Leu Thr Thr Asn Pro  Gly Asn Gln 
    1160                 1165                 1170             


Leu Asn  
    1175 


<210> 208
<211> 1285
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Herbinix hemicellulosilytica sequence

<400> 208
Met Lys Leu Thr Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys 
1               5                   10                  15      


Ile Thr Ala Ala Phe Tyr Arg Asp Met Ser Gln Gly Leu Leu Tyr Tyr 
            20                  25                  30          


Asp Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp 
        35                  40                  45              


Phe Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp 
    50                  55                  60                  


Lys Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp 
65                  70                  75                  80  


Lys Ile Val Cys Glu Pro Ile Asp Val Asp Ser Asp Pro Asp Asn Leu 
                85                  90                  95      


Asp Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys 
            100                 105                 110         


Ala Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln 
        115                 120                 125             


Ala Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys 
    130                 135                 140                 


Glu Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys 
145                 150                 155                 160 


Ser Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu 
                165                 170                 175     


Val Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val 
            180                 185                 190         


Pro Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile 
        195                 200                 205             


Tyr Asp Tyr Asp Lys Leu Lys Ala Asn Ile Thr Asn Arg Leu Asp Lys 
    210                 215                 220                 


Thr Asp Lys Lys Ala Arg Ser Ile Ser Arg Ala Val Ser Glu Glu Leu 
225                 230                 235                 240 


Arg Glu Tyr His Lys Asn Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser 
                245                 250                 255     


Gly Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr 
            260                 265                 270         


Asn Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln 
        275                 280                 285             


Tyr Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser 
    290                 295                 300                 


Lys Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys 
305                 310                 315                 320 


Val Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala 
                325                 330                 335     


Gly Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp 
            340                 345                 350         


Thr Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln 
        355                 360                 365             


Val Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly 
    370                 375                 380                 


Ile Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys 
385                 390                 395                 400 


Phe Asp Asp Ile Thr Thr Lys Lys Ala Lys Glu Ala Ile Glu Ser Asn 
                405                 410                 415     


Tyr Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys 
            420                 425                 430         


Glu Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp 
        435                 440                 445             


Arg Pro Asp Asp Asp Ile Glu Asn Leu Ile Val Leu Val Lys Asn Ala 
    450                 455                 460                 


Ile Glu Ser Val Ser Tyr Leu Arg Asn Arg Thr Phe His Phe Lys Glu 
465                 470                 475                 480 


Ser Ser Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly 
                485                 490                 495     


Gln Asn Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp 
            500                 505                 510         


Ile Glu Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly 
        515                 520                 525             


Ile Ala Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr 
    530                 535                 540                 


Cys Gly Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro 
545                 550                 555                 560 


Ala Phe Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr 
                565                 570                 575     


Ile Arg Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser 
            580                 585                 590         


Tyr Lys Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val 
        595                 600                 605             


Lys Asn Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu 
    610                 615                 620                 


Ile Tyr Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu 
625                 630                 635                 640 


Ile Thr Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr 
                645                 650                 655     


Glu Glu Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp 
            660                 665                 670         


Glu Asn Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro 
        675                 680                 685             


Asp Tyr Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg 
    690                 695                 700                 


Lys Gln Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn 
705                 710                 715                 720 


Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly 
                725                 730                 735     


Ala Tyr Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro 
            740                 745                 750         


Pro Leu Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu 
        755                 760                 765             


Phe Pro Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe 
    770                 775                 780                 


Ser Ile Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr 
785                 790                 795                 800 


Ser Ala Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys 
                805                 810                 815     


Lys Asn Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg 
            820                 825                 830         


Leu Leu Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys 
        835                 840                 845             


Tyr Arg Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Lys 
    850                 855                 860                 


Leu Glu Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu 
865                 870                 875                 880 


Leu Val Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala 
                885                 890                 895     


Glu Ser Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile 
            900                 905                 910         


Glu Lys Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His 
        915                 920                 925             


Ser Asp Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met 
    930                 935                 940                 


Arg Ser Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr 
945                 950                 955                 960 


Leu Ile Thr Lys Lys Glu Cys Leu Glu Tyr Ile Lys Leu Ser Asn Ile 
                965                 970                 975     


Ile Lys Asp Tyr Gln Asn Ser Leu Asn Glu Leu His Glu Gln Leu Glu 
            980                 985                 990         


Arg Ile Lys Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
        995                 1000                 1005             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1010                 1015                 1020             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1025                 1030                 1035             


Phe Glu  Ser Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1040                 1045                 1050             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1055                 1060                 1065             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1070                 1075                 1080             


Arg Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Asp Asn  Asn Asp Gly 
    1085                 1090                 1095             


Arg Ile  Val Lys Lys Ile Gln  Asn Asn Leu Asn Asn  Lys Asn Arg 
    1100                 1105                 1110             


Glu Leu  Val Ser Met Leu Cys  Trp Asn Lys Lys Leu  Asn Lys Asn 
    1115                 1120                 1125             


Glu Phe  Gly Ala Ile Ile Trp  Lys Arg Asn Pro Ile  Ala His Leu 
    1130                 1135                 1140             


Asn His  Phe Thr Gln Thr Glu  Gln Asn Ser Lys Ser  Ser Leu Glu 
    1145                 1150                 1155             


Ser Leu  Ile Asn Ser Leu Arg  Ile Leu Leu Ala Tyr  Asp Arg Lys 
    1160                 1165                 1170             


Arg Gln  Asn Ala Val Thr Lys  Thr Ile Asn Asp Leu  Leu Leu Asn 
    1175                 1180                 1185             


Asp Tyr  His Ile Arg Ile Lys  Trp Glu Gly Arg Val  Asp Glu Gly 
    1190                 1195                 1200             


Gln Ile  Tyr Phe Asn Ile Lys  Glu Lys Glu Asp Ile  Glu Asn Glu 
    1205                 1210                 1215             


Pro Ile  Ile His Leu Lys His  Leu His Lys Lys Asp  Cys Tyr Ile 
    1220                 1225                 1230             


Tyr Lys  Asn Ser Tyr Met Phe  Asp Lys Gln Lys Glu  Trp Ile Cys 
    1235                 1240                 1245             


Asn Gly  Ile Lys Glu Glu Val  Tyr Asp Lys Ser Ile  Leu Lys Cys 
    1250                 1255                 1260             


Ile Gly  Asn Leu Phe Lys Phe  Asp Tyr Glu Asp Lys  Asn Lys Ser 
    1265                 1270                 1275             


Ser Ala  Asn Pro Lys His Thr  
    1280                 1285 


<210> 209
<211> 1154
<212> PRT
<213> Paludibacter propionicigenes

<400> 209
Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Ser Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Thr Leu Asn Lys Thr Ile Ile Lys Phe Asp 
    50                  55                  60                  


Thr Ala Lys Lys Gln Lys Leu Asn Val Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Lys Ala 
                85                  90                  95      


Glu Glu Ile Leu Pro Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Gln Ala Gln Asp Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Ala Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Lys Met Leu Gln Asp Val Lys Pro Leu Thr Asp Asp Lys Gly Lys Ile 
    210                 215                 220                 


Asn Thr Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Val Pro Asn Glu Ala Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ala His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr 
        355                 360                 365             


Asn Asp Ile Leu Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp 
    370                 375                 380                 


Asn Thr Asn Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Gly Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Lys Thr Val Phe Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Arg Phe 
    450                 455                 460                 


Ile Asn Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Val Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Gln Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ser Tyr Asn Ala Arg Tyr Phe Met Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Gly Phe Thr Thr Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys 
            580                 585                 590         


Gln Ala Glu Lys Val Asn Pro Arg Lys Lys Glu Ala Tyr Ala Phe Glu 
        595                 600                 605             


Ala Val Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala 
    610                 615                 620                 


Tyr Val Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys 
625                 630                 635                 640 


Val Ala Glu Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val 
                645                 650                 655     


Phe Ile Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe 
            660                 665                 670         


Val Gln Met Pro Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln 
        675                 680                 685             


Lys Ala Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys 
    690                 695                 700                 


Lys Leu Thr Pro Gln Tyr Ala Lys Ala Asp Asp Ala Thr His Ile Ala 
705                 710                 715                 720 


Phe Tyr Val Phe Cys Lys Leu Leu Asp Ala Ala His Leu Ser Asn Leu 
                725                 730                 735     


Arg Asn Glu Leu Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe 
            740                 745                 750         


His His Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val 
        755                 760                 765             


Val Pro Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu 
    770                 775                 780                 


Ala Arg Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp 
785                 790                 795                 800 


Ser Asp Leu Phe Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala 
                805                 810                 815     


Asn Ile Glu Leu Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln 
            820                 825                 830         


Ile Ile Asn Lys Asp Thr Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr 
        835                 840                 845             


Ala Trp Asn Thr Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg 
    850                 855                 860                 


Glu Asp His His Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys 
865                 870                 875                 880 


Glu Lys Gln Glu Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe 
                885                 890                 895     


Ile Glu Lys His Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn 
            900                 905                 910         


Thr Tyr Asn Trp Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg 
        915                 920                 925             


Leu His Gly Leu Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val 
    930                 935                 940                 


Ala Leu Phe Asp Arg Asp Phe Gln Phe Phe Asp Glu Gln Gln Ile Ala 
945                 950                 955                 960 


Asp Glu Phe Lys Leu His Gly Phe Val Asn Leu His Ser Ile Asp Lys 
                965                 970                 975     


Lys Leu Asn Glu Val Pro Thr Lys Lys Ile Lys Glu Ile Tyr Asp Ile 
            980                 985                 990         


Arg Asn Lys Ile Ile Gln Ile Asn  Gly Asn Lys Ile Asn  Glu Ser Val 
        995                 1000                 1005             


Arg Ala  Asn Leu Ile Gln Phe  Ile Ser Ser Lys Arg  Asn Tyr Tyr 
    1010                 1015                 1020             


Asn Asn  Ala Phe Leu His Val  Ser Asn Asp Glu Ile  Lys Glu Lys 
    1025                 1030                 1035             


Gln Met  Tyr Asp Ile Arg Asn  His Ile Ala His Phe  Asn Tyr Leu 
    1040                 1045                 1050             


Thr Lys  Asp Ala Ala Asp Phe  Ser Leu Ile Asp Leu  Ile Asn Glu 
    1055                 1060                 1065             


Leu Arg  Glu Leu Leu His Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1070                 1075                 1080             


Ser Lys  Ala Phe Ile Asp Leu  Phe Asp Lys His Gly  Met Ile Leu 
    1085                 1090                 1095             


Lys Leu  Lys Leu Asn Ala Asp  His Lys Leu Lys Val  Glu Ser Leu 
    1100                 1105                 1110             


Glu Pro  Lys Lys Ile Tyr His  Leu Gly Ser Ser Ala  Lys Asp Lys 
    1115                 1120                 1125             


Pro Glu  Tyr Gln Tyr Cys Thr  Asn Gln Val Met Met  Ala Tyr Cys 
    1130                 1135                 1140             


Asn Met  Cys Arg Ser Leu Leu  Glu Met Lys Lys 
    1145                 1150                 


<210> 210
<211> 1182
<212> PRT
<213> Leptotrichia wadei

<400> 210
Met Tyr Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Lys 
1               5                   10                  15      


Gln Asp Lys Gly Ile Leu Lys Lys Lys Trp Lys Asp Leu Asp Glu Arg 
            20                  25                  30          


Lys Gln Arg Glu Lys Ile Glu Ala Arg Tyr Asn Lys Gln Ile Glu Ser 
        35                  40                  45              


Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Asn Lys Lys Arg Ile Glu 
    50                  55                  60                  


Lys Glu Glu Asp Gln Asn Ile Lys Ser Leu Tyr Phe Phe Ile Lys Glu 
65                  70                  75                  80  


Leu Tyr Leu Asn Glu Lys Asn Glu Glu Trp Glu Leu Lys Asn Ile Asn 
                85                  90                  95      


Leu Glu Ile Leu Asp Asp Lys Glu Arg Val Ile Lys Gly Tyr Lys Phe 
            100                 105                 110         


Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Tyr Lys Glu Tyr Tyr Leu 
        115                 120                 125             


Arg Ile Leu Phe Asn Asn Leu Ile Glu Lys Val Gln Asn Glu Asn Arg 
    130                 135                 140                 


Glu Lys Val Arg Lys Asn Lys Glu Phe Leu Asp Leu Lys Glu Ile Phe 
145                 150                 155                 160 


Lys Lys Tyr Lys Asn Arg Lys Ile Asp Leu Leu Leu Lys Ser Ile Asn 
                165                 170                 175     


Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val Asn Glu Glu 
            180                 185                 190         


Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr Phe Tyr Glu 
        195                 200                 205             


Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys Ser Ile Leu 
    210                 215                 220                 


Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu Glu Asn Ile 
225                 230                 235                 240 


Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile Lys Gly Lys 
                245                 250                 255     


Val Leu Asn Glu Leu Arg Glu Tyr Ile Lys Glu Lys Glu Glu Asn Asn 
            260                 265                 270         


Ser Asp Asn Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu Lys Lys Tyr 
        275                 280                 285             


Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys Ser Lys Asn 
    290                 295                 300                 


Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys Ile Met Phe 
305                 310                 315                 320 


Ile Glu Glu Val Asp Glu Lys Lys Glu Ile Asn Lys Glu Lys Phe Lys 
                325                 330                 335     


Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln His Ile Leu 
            340                 345                 350         


Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu Tyr Ile Lys 
        355                 360                 365             


Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys 
    370                 375                 380                 


Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn 
385                 390                 395                 400 


Ser Tyr Tyr Asn Leu Phe Gly Arg Val Ser Gly Asp Ile Leu Gly Thr 
                405                 410                 415     


Glu Val Val Lys Ser Ser Lys Thr Asn Val Ile Lys Val Gly Ser His 
            420                 425                 430         


Ile Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Phe Glu Ile Phe 
        435                 440                 445             


Asp Ala Asn Lys Ile Val Glu Ile Leu Glu Ser Ile Ser Tyr Ser Ile 
    450                 455                 460                 


Tyr Asn Val Arg Asn Gly Val Gly His Phe Asn Lys Leu Ile Leu Gly 
465                 470                 475                 480 


Lys Tyr Lys Lys Lys Asp Ile Asn Thr Asn Lys Arg Ile Glu Glu Asp 
                485                 490                 495     


Leu Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Lys Lys Arg Gly 
            500                 505                 510         


Glu Ile Glu Arg Lys Val Lys Glu Lys Phe Leu Ser Asn Asn Leu Gln 
        515                 520                 525             


Tyr Tyr Tyr Ser Lys Glu Lys Ile Glu Asn Tyr Phe Glu Val Tyr Glu 
    530                 535                 540                 


Phe Glu Ile Leu Lys Arg Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg 
545                 550                 555                 560 


Ile Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Asn Asn Lys Lys 
                565                 570                 575     


Tyr Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala Glu Glu Lys Lys 
            580                 585                 590         


Glu Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn 
        595                 600                 605             


Asn Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Phe Glu Lys Ile 
    610                 615                 620                 


Val Leu Glu Val Lys Glu Glu Lys Lys Ser Arg Gly Asn Ile Asn Asn 
625                 630                 635                 640 


Lys Lys Ser Gly Val Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys 
                645                 650                 655     


Ile Asn Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu 
            660                 665                 670         


Arg Val Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr 
        675                 680                 685             


Ile Arg Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr 
    690                 695                 700                 


Leu Glu Lys Asp Lys Arg Leu His Phe Leu Lys Glu Glu Phe Ser Ile 
705                 710                 715                 720 


Leu Cys Asn Asn Asn Asn Asn Val Val Asp Phe Asn Ile Asn Ile Asn 
                725                 730                 735     


Glu Glu Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu 
            740                 745                 750         


Asn Leu Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu 
        755                 760                 765             


Phe Arg Asn Glu Leu Val Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu 
    770                 775                 780                 


Asp Glu Glu Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr 
785                 790                 795                 800 


Leu Ile Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys 
                805                 810                 815     


Ser Glu Glu Ile Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Asp 
            820                 825                 830         


Ser Asn Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp 
        835                 840                 845             


Glu Lys Ile Leu Ser Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn 
    850                 855                 860                 


Lys Thr Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly 
865                 870                 875                 880 


Thr Gln Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys 
                885                 890                 895     


Val Glu Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu 
            900                 905                 910         


Gln Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu 
        915                 920                 925             


Leu His Lys Lys Trp Glu Gln Asn Lys Ile Thr Glu Lys Glu Ile Glu 
    930                 935                 940                 


Lys Tyr Asn Asn Thr Thr Arg Lys Ile Asn Glu Tyr Asn Tyr Leu Lys 
945                 950                 955                 960 


Asn Lys Glu Glu Leu Gln Asn Val Tyr Leu Leu His Glu Met Leu Ser 
                965                 970                 975     


Asp Leu Leu Ala Arg Asn Val Ala Phe Phe Asn Lys Trp Glu Arg Asp 
            980                 985                 990         


Phe Lys Phe Ile Val Ile Ala Ile  Lys Gln Phe Leu Arg  Glu Asn Asp 
        995                 1000                 1005             


Lys Glu  Lys Val Asn Glu Phe  Leu Asn Pro Pro Asp  Asn Ser Lys 
    1010                 1015                 1020             


Gly Lys  Lys Val Tyr Phe Ser  Val Ser Lys Tyr Lys  Asn Thr Val 
    1025                 1030                 1035             


Glu Asn  Ile Asp Gly Ile His  Lys Asn Phe Met Asn  Leu Ile Phe 
    1040                 1045                 1050             


Leu Asn  Asn Lys Phe Met Asn  Arg Lys Ile Asp Lys  Met Asn Cys 
    1055                 1060                 1065             


Ala Ile  Trp Val Tyr Phe Arg  Asn Tyr Ile Ala His  Phe Leu His 
    1070                 1075                 1080             


Leu His  Thr Lys Asn Glu Lys  Ile Ser Leu Ile Ser  Gln Met Asn 
    1085                 1090                 1095             


Leu Leu  Ile Lys Leu Phe Ser  Tyr Asp Lys Lys Val  Gln Asn His 
    1100                 1105                 1110             


Ile Leu  Lys Ser Thr Lys Thr  Leu Leu Glu Lys Tyr  Asn Ile Gln 
    1115                 1120                 1125             


Ile Asn  Phe Glu Ile Ser Asn  Asp Lys Asn Glu Val  Phe Lys Tyr 
    1130                 1135                 1140             


Lys Ile  Lys Asn Arg Leu Tyr  Ser Lys Lys Gly Lys  Met Leu Gly 
    1145                 1150                 1155             


Lys Asn  Asn Lys Phe Glu Ile  Leu Glu Asn Glu Phe  Leu Glu Asn 
    1160                 1165                 1170             


Val Lys  Ala Met Leu Glu Tyr  Ser Glu 
    1175                 1180         


<210> 211
<211> 1224
<212> PRT
<213> Bergeyella zoohelcum

<400> 211
Met Glu Asn Lys Thr Ser Leu Gly Asn Asn Ile Tyr Tyr Asn Pro Phe 
1               5                   10                  15      


Lys Pro Gln Asp Lys Ser Tyr Phe Ala Gly Tyr Phe Asn Ala Ala Met 
            20                  25                  30          


Glu Asn Thr Asp Ser Val Phe Arg Glu Leu Gly Lys Arg Leu Lys Gly 
        35                  40                  45              


Lys Glu Tyr Thr Ser Glu Asn Phe Phe Asp Ala Ile Phe Lys Glu Asn 
    50                  55                  60                  


Ile Ser Leu Val Glu Tyr Glu Arg Tyr Val Lys Leu Leu Ser Asp Tyr 
65                  70                  75                  80  


Phe Pro Met Ala Arg Leu Leu Asp Lys Lys Glu Val Pro Ile Lys Glu 
                85                  90                  95      


Arg Lys Glu Asn Phe Lys Lys Asn Phe Lys Gly Ile Ile Lys Ala Val 
            100                 105                 110         


Arg Asp Leu Arg Asn Phe Tyr Thr His Lys Glu His Gly Glu Val Glu 
        115                 120                 125             


Ile Thr Asp Glu Ile Phe Gly Val Leu Asp Glu Met Leu Lys Ser Thr 
    130                 135                 140                 


Val Leu Thr Val Lys Lys Lys Lys Val Lys Thr Asp Lys Thr Lys Glu 
145                 150                 155                 160 


Ile Leu Lys Lys Ser Ile Glu Lys Gln Leu Asp Ile Leu Cys Gln Lys 
                165                 170                 175     


Lys Leu Glu Tyr Leu Arg Asp Thr Ala Arg Lys Ile Glu Glu Lys Arg 
            180                 185                 190         


Arg Asn Gln Arg Glu Arg Gly Glu Lys Glu Leu Val Ala Pro Phe Lys 
        195                 200                 205             


Tyr Ser Asp Lys Arg Asp Asp Leu Ile Ala Ala Ile Tyr Asn Asp Ala 
    210                 215                 220                 


Phe Asp Val Tyr Ile Asp Lys Lys Lys Asp Ser Leu Lys Glu Ser Ser 
225                 230                 235                 240 


Lys Ala Lys Tyr Asn Thr Lys Ser Asp Pro Gln Gln Glu Glu Gly Asp 
                245                 250                 255     


Leu Lys Ile Pro Ile Ser Lys Asn Gly Val Val Phe Leu Leu Ser Leu 
            260                 265                 270         


Phe Leu Thr Lys Gln Glu Ile His Ala Phe Lys Ser Lys Ile Ala Gly 
        275                 280                 285             


Phe Lys Ala Thr Val Ile Asp Glu Ala Thr Val Ser Glu Ala Thr Val 
    290                 295                 300                 


Ser His Gly Lys Asn Ser Ile Cys Phe Met Ala Thr His Glu Ile Phe 
305                 310                 315                 320 


Ser His Leu Ala Tyr Lys Lys Leu Lys Arg Lys Val Arg Thr Ala Glu 
                325                 330                 335     


Ile Asn Tyr Gly Glu Ala Glu Asn Ala Glu Gln Leu Ser Val Tyr Ala 
            340                 345                 350         


Lys Glu Thr Leu Met Met Gln Met Leu Asp Glu Leu Ser Lys Val Pro 
        355                 360                 365             


Asp Val Val Tyr Gln Asn Leu Ser Glu Asp Val Gln Lys Thr Phe Ile 
    370                 375                 380                 


Glu Asp Trp Asn Glu Tyr Leu Lys Glu Asn Asn Gly Asp Val Gly Thr 
385                 390                 395                 400 


Met Glu Glu Glu Gln Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu 
                405                 410                 415     


Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Gln 
            420                 425                 430         


Phe Pro Thr Leu Arg Phe Gln Val His Leu Gly Asn Tyr Leu His Asp 
        435                 440                 445             


Ser Arg Pro Lys Glu Asn Leu Ile Ser Asp Arg Arg Ile Lys Glu Lys 
    450                 455                 460                 


Ile Thr Val Phe Gly Arg Leu Ser Glu Leu Glu His Lys Lys Ala Leu 
465                 470                 475                 480 


Phe Ile Lys Asn Thr Glu Thr Asn Glu Asp Arg Glu His Tyr Trp Glu 
                485                 490                 495     


Ile Phe Pro Asn Pro Asn Tyr Asp Phe Pro Lys Glu Asn Ile Ser Val 
            500                 505                 510         


Asn Asp Lys Asp Phe Pro Ile Ala Gly Ser Ile Leu Asp Arg Glu Lys 
        515                 520                 525             


Gln Pro Val Ala Gly Lys Ile Gly Ile Lys Val Lys Leu Leu Asn Gln 
    530                 535                 540                 


Gln Tyr Val Ser Glu Val Asp Lys Ala Val Lys Ala His Gln Leu Lys 
545                 550                 555                 560 


Gln Arg Lys Ala Ser Lys Pro Ser Ile Gln Asn Ile Ile Glu Glu Ile 
                565                 570                 575     


Val Pro Ile Asn Glu Ser Asn Pro Lys Glu Ala Ile Val Phe Gly Gly 
            580                 585                 590         


Gln Pro Thr Ala Tyr Leu Ser Met Asn Asp Ile His Ser Ile Leu Tyr 
        595                 600                 605             


Glu Phe Phe Asp Lys Trp Glu Lys Lys Lys Glu Lys Leu Glu Lys Lys 
    610                 615                 620                 


Gly Glu Lys Glu Leu Arg Lys Glu Ile Gly Lys Glu Leu Glu Lys Lys 
625                 630                 635                 640 


Ile Val Gly Lys Ile Gln Ala Gln Ile Gln Gln Ile Ile Asp Lys Asp 
                645                 650                 655     


Thr Asn Ala Lys Ile Leu Lys Pro Tyr Gln Asp Gly Asn Ser Thr Ala 
            660                 665                 670         


Ile Asp Lys Glu Lys Leu Ile Lys Asp Leu Lys Gln Glu Gln Asn Ile 
        675                 680                 685             


Leu Gln Lys Leu Lys Asp Glu Gln Thr Val Arg Glu Lys Glu Tyr Asn 
    690                 695                 700                 


Asp Phe Ile Ala Tyr Gln Asp Lys Asn Arg Glu Ile Asn Lys Val Arg 
705                 710                 715                 720 


Asp Arg Asn His Lys Gln Tyr Leu Lys Asp Asn Leu Lys Arg Lys Tyr 
                725                 730                 735     


Pro Glu Ala Pro Ala Arg Lys Glu Val Leu Tyr Tyr Arg Glu Lys Gly 
            740                 745                 750         


Lys Val Ala Val Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Thr 
        755                 760                 765             


Asp Phe Lys Asn Glu Trp Lys Gly Glu Gln His Ser Leu Leu Gln Lys 
    770                 775                 780                 


Ser Leu Ala Tyr Tyr Glu Gln Cys Lys Glu Glu Leu Lys Asn Leu Leu 
785                 790                 795                 800 


Pro Glu Lys Val Phe Gln His Leu Pro Phe Lys Leu Gly Gly Tyr Phe 
                805                 810                 815     


Gln Gln Lys Tyr Leu Tyr Gln Phe Tyr Thr Cys Tyr Leu Asp Lys Arg 
            820                 825                 830         


Leu Glu Tyr Ile Ser Gly Leu Val Gln Gln Ala Glu Asn Phe Lys Ser 
        835                 840                 845             


Glu Asn Lys Val Phe Lys Lys Val Glu Asn Glu Cys Phe Lys Phe Leu 
    850                 855                 860                 


Lys Lys Gln Asn Tyr Thr His Lys Glu Leu Asp Ala Arg Val Gln Ser 
865                 870                 875                 880 


Ile Leu Gly Tyr Pro Ile Phe Leu Glu Arg Gly Phe Met Asp Glu Lys 
                885                 890                 895     


Pro Thr Ile Ile Lys Gly Lys Thr Phe Lys Gly Asn Glu Ala Leu Phe 
            900                 905                 910         


Ala Asp Trp Phe Arg Tyr Tyr Lys Glu Tyr Gln Asn Phe Gln Thr Phe 
        915                 920                 925             


Tyr Asp Thr Glu Asn Tyr Pro Leu Val Glu Leu Glu Lys Lys Gln Ala 
    930                 935                 940                 


Asp Arg Lys Arg Lys Thr Lys Ile Tyr Gln Gln Lys Lys Asn Asp Val 
945                 950                 955                 960 


Phe Thr Leu Leu Met Ala Lys His Ile Phe Lys Ser Val Phe Lys Gln 
                965                 970                 975     


Asp Ser Ile Asp Gln Phe Ser Leu Glu Asp Leu Tyr Gln Ser Arg Glu 
            980                 985                 990         


Glu Arg Leu Gly Asn Gln Glu Arg  Ala Arg Gln Thr Gly  Glu Arg Asn 
        995                 1000                 1005             


Thr Asn  Tyr Ile Trp Asn Lys  Thr Val Asp Leu Lys  Leu Cys Asp 
    1010                 1015                 1020             


Gly Lys  Ile Thr Val Glu Asn  Val Lys Leu Lys Asn  Val Gly Asp 
    1025                 1030                 1035             


Phe Ile  Lys Tyr Glu Tyr Asp  Gln Arg Val Gln Ala  Phe Leu Lys 
    1040                 1045                 1050             


Tyr Glu  Glu Asn Ile Glu Trp  Gln Ala Phe Leu Ile  Lys Glu Ser 
    1055                 1060                 1065             


Lys Glu  Glu Glu Asn Tyr Pro  Tyr Val Val Glu Arg  Glu Ile Glu 
    1070                 1075                 1080             


Gln Tyr  Glu Lys Val Arg Arg  Glu Glu Leu Leu Lys  Glu Val His 
    1085                 1090                 1095             


Leu Ile  Glu Glu Tyr Ile Leu  Glu Lys Val Lys Asp  Lys Glu Ile 
    1100                 1105                 1110             


Leu Lys  Lys Gly Asp Asn Gln  Asn Phe Lys Tyr Tyr  Ile Leu Asn 
    1115                 1120                 1125             


Gly Leu  Leu Lys Gln Leu Lys  Asn Glu Asp Val Glu  Ser Tyr Lys 
    1130                 1135                 1140             


Val Phe  Asn Leu Asn Thr Glu  Pro Glu Asp Val Asn  Ile Asn Gln 
    1145                 1150                 1155             


Leu Lys  Gln Glu Ala Thr Asp  Leu Glu Gln Lys Ala  Phe Val Leu 
    1160                 1165                 1170             


Thr Tyr  Ile Arg Asn Lys Phe  Ala His Asn Gln Leu  Pro Lys Lys 
    1175                 1180                 1185             


Glu Phe  Trp Asp Tyr Cys Gln  Glu Lys Tyr Gly Lys  Ile Glu Lys 
    1190                 1195                 1200             


Glu Lys  Thr Tyr Ala Glu Tyr  Phe Ala Glu Val Phe  Lys Lys Glu 
    1205                 1210                 1215             


Lys Glu  Ala Leu Ile Lys 
    1220                 


<210> 212
<211> 1126
<212> PRT
<213> Prevotella intermedia

<400> 212
Met Glu Asp Asp Lys Lys Thr Thr Asp Ser Ile Arg Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Thr Thr Leu Lys Asn Thr Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Ala Thr Tyr Arg Leu Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Arg Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Gly Leu Leu Glu Lys Met Tyr Asn Ile Phe Asn Ala Ser 
145                 150                 155                 160 


Ile Arg Leu Val Lys Glu Asp Tyr Gln Tyr Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Glu Glu Phe Asn Tyr 
            180                 185                 190         


Tyr Phe Thr Lys Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln 
    210                 215                 220                 


Gln Lys Leu Arg Gly Phe Lys Asp Asn Arg Glu Asn Lys Lys Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Gln Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Glu 
        275                 280                 285             


Asp Arg Glu Lys Phe Arg Val Pro Ile Glu Ile Ala Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Gln Ile Gly Asp Tyr Lys Glu Ser His His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Arg Lys Phe Val Lys Thr Phe Asn Ser Phe Glu Thr 
385                 390                 395                 400 


Ser Lys Glu Pro Tyr Ile Pro Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Asp Asn Asp Lys Ile Trp 
            420                 425                 430         


Pro Ser Leu Lys Thr Asn Ser Glu Lys Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Ser Phe Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu Asn Thr Asp 
465                 470                 475                 480 


Asn Asp Asn Glu Ile Glu Thr Lys Lys Lys Glu Asn Lys Asn Asp Lys 
                485                 490                 495     


Gln Glu Lys His Lys Ile Glu Glu Ile Ile Glu Asn Lys Ile Thr Glu 
            500                 505                 510         


Ile Tyr Ala Leu Tyr Asp Thr Phe Ala Asn Gly Glu Ile Lys Ser Ile 
        515                 520                 525             


Asp Glu Leu Glu Glu Tyr Cys Lys Gly Lys Asp Ile Glu Ile Gly His 
    530                 535                 540                 


Leu Pro Lys Gln Met Ile Ala Ile Leu Lys Asp Glu His Lys Val Met 
545                 550                 555                 560 


Ala Thr Glu Ala Glu Arg Lys Gln Glu Glu Met Leu Val Asp Val Gln 
                565                 570                 575     


Lys Ser Leu Glu Ser Leu Asp Asn Gln Ile Asn Glu Glu Ile Glu Asn 
            580                 585                 590         


Val Glu Arg Lys Asn Ser Ser Leu Lys Ser Gly Lys Ile Ala Ser Trp 
        595                 600                 605             


Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu 
    610                 615                 620                 


Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu 
625                 630                 635                 640 


Leu Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Ala 
                645                 650                 655     


Pro Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His Pro 
            660                 665                 670         


Phe Leu Lys Asp Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Glu Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro 
705                 710                 715                 720 


Lys Thr Lys Pro Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Lys 
            740                 745                 750         


His Arg Glu Asn Ile Thr Val Ala Glu Leu Lys Arg Val Gly Leu Val 
        755                 760                 765             


Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Glu Tyr Lys Asp Ser Val 
    770                 775                 780                 


Gln Pro Phe Tyr Asn Tyr His Phe Asn Val Gly Asn Ile Asn Lys Pro 
785                 790                 795                 800 


Asp Glu Lys Asn Phe Leu Asn Cys Glu Glu Arg Arg Glu Leu Leu Arg 
                805                 810                 815     


Lys Lys Lys Asp Glu Phe Lys Lys Met Thr Asp Lys Glu Lys Glu Glu 
            820                 825                 830         


Asn Pro Ser Tyr Leu Glu Phe Lys Ser Trp Asn Lys Phe Glu Arg Glu 
        835                 840                 845             


Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Met 
    850                 855                 860                 


Glu Leu Phe Asn Lys Lys Lys Ile Lys Glu Leu Asn Val Glu Lys Ile 
865                 870                 875                 880 


Tyr Leu Lys Asn Ile Asn Thr Asn Thr Thr Lys Lys Glu Lys Asn Thr 
                885                 890                 895     


Glu Glu Lys Asn Gly Glu Glu Lys Asn Ile Lys Glu Lys Asn Asn Ile 
            900                 905                 910         


Leu Asn Arg Ile Met Pro Met Arg Leu Pro Ile Lys Val Tyr Gly Arg 
        915                 920                 925             


Glu Asn Phe Ser Lys Asn Lys Lys Lys Lys Ile Arg Arg Asn Thr Phe 
    930                 935                 940                 


Phe Thr Val Tyr Ile Glu Glu Lys Gly Thr Lys Leu Leu Lys Gln Gly 
945                 950                 955                 960 


Asn Phe Lys Ala Leu Glu Arg Asp Arg Arg Leu Gly Gly Leu Phe Ser 
                965                 970                 975     


Phe Val Lys Thr Pro Ser Lys Ala Glu Ser Lys Ser Asn Thr Ile Ser 
            980                 985                 990         


Lys Leu Arg Val Glu Tyr Glu Leu  Gly Glu Tyr Gln Lys  Ala Arg Ile 
        995                 1000                 1005             


Glu Ile  Ile Lys Asp Met Leu  Ala Leu Glu Lys Thr  Leu Ile Asp 
    1010                 1015                 1020             


Lys Tyr  Asn Ser Leu Asp Thr  Asp Asn Phe Asn Lys  Met Leu Thr 
    1025                 1030                 1035             


Asp Trp  Leu Glu Leu Lys Gly  Glu Pro Asp Lys Ala  Ser Phe Gln 
    1040                 1045                 1050             


Asn Asp  Val Asp Leu Leu Ile  Ala Val Arg Asn Ala  Phe Ser His 
    1055                 1060                 1065             


Asn Gln  Tyr Pro Met Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn 
    1070                 1075                 1080             


Pro Phe  Ser Leu Ser Ser Ala  Asn Thr Ser Glu Glu  Lys Gly Leu 
    1085                 1090                 1095             


Gly Ile  Ala Asn Gln Leu Lys  Asp Lys Thr His Lys  Thr Ile Glu 
    1100                 1105                 1110             


Lys Ile  Ile Glu Ile Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1115                 1120                 1125     


<210> 213
<211> 1127
<212> PRT
<213> Prevotella buccae

<400> 213
Met Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Met Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asn Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Ala His Asn Asn Leu Phe Pro Ser Leu Gln Thr Asp Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Arg Arg Leu Gln Asn 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Lys Gly Arg Gln Lys Asp Met Gly Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Arg Leu Lys Pro Lys Lys Arg Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Phe Ser Phe Ala Glu Thr Thr Asp Leu Asn 
            980                 985                 990         


Leu Glu Glu His Pro Ile Ser Lys  Leu Ser Val Asp Leu  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210> 214
<211> 1135
<212> PRT
<213> Porphyromonas gingivalis

<400> 214
Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Val Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Phe Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asp Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Gln Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Gly Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Ile Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Met Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210> 215
<211> 1115
<212> PRT
<213> Bacteroides pyogenes

<400> 215
Met Glu Ser Ile Lys Asn Ser Gln Lys Ser Thr Gly Lys Thr Leu Gln 
1               5                   10                  15      


Lys Asp Pro Pro Tyr Phe Gly Leu Tyr Leu Asn Met Ala Leu Leu Asn 
            20                  25                  30          


Val Arg Lys Val Glu Asn His Ile Arg Lys Trp Leu Gly Asp Val Ala 
        35                  40                  45              


Leu Leu Pro Glu Lys Ser Gly Phe His Ser Leu Leu Thr Thr Asp Asn 
    50                  55                  60                  


Leu Ser Ser Ala Lys Trp Thr Arg Phe Tyr Tyr Lys Ser Arg Lys Phe 
65                  70                  75                  80  


Leu Pro Phe Leu Glu Met Phe Asp Ser Asp Lys Lys Ser Tyr Glu Asn 
                85                  90                  95      


Arg Arg Glu Thr Ala Glu Cys Leu Asp Thr Ile Asp Arg Gln Lys Ile 
            100                 105                 110         


Ser Ser Leu Leu Lys Glu Val Tyr Gly Lys Leu Gln Asp Ile Arg Asn 
        115                 120                 125             


Ala Phe Ser His Tyr His Ile Asp Asp Gln Ser Val Lys His Thr Ala 
    130                 135                 140                 


Leu Ile Ile Ser Ser Glu Met His Arg Phe Ile Glu Asn Ala Tyr Ser 
145                 150                 155                 160 


Phe Ala Leu Gln Lys Thr Arg Ala Arg Phe Thr Gly Val Phe Val Glu 
                165                 170                 175     


Thr Asp Phe Leu Gln Ala Glu Glu Lys Gly Asp Asn Lys Lys Phe Phe 
            180                 185                 190         


Ala Ile Gly Gly Asn Glu Gly Ile Lys Leu Lys Asp Asn Ala Leu Ile 
        195                 200                 205             


Phe Leu Ile Cys Leu Phe Leu Asp Arg Glu Glu Ala Phe Lys Phe Leu 
    210                 215                 220                 


Ser Arg Ala Thr Gly Phe Lys Ser Thr Lys Glu Lys Gly Phe Leu Ala 
225                 230                 235                 240 


Val Arg Glu Thr Phe Cys Ala Leu Cys Cys Arg Gln Pro His Glu Arg 
                245                 250                 255     


Leu Leu Ser Val Asn Pro Arg Glu Ala Leu Leu Met Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Asn Arg Cys Pro Asp Ile Leu Phe Glu Met Leu Asp Glu Lys 
        275                 280                 285             


Asp Gln Lys Ser Phe Leu Pro Leu Leu Gly Glu Glu Glu Gln Ala His 
    290                 295                 300                 


Ile Leu Glu Asn Ser Leu Asn Asp Glu Leu Cys Glu Ala Ile Asp Asp 
305                 310                 315                 320 


Pro Phe Glu Met Ile Ala Ser Leu Ser Lys Arg Val Arg Tyr Lys Asn 
                325                 330                 335     


Arg Phe Pro Tyr Leu Met Leu Arg Tyr Ile Glu Glu Lys Asn Leu Leu 
            340                 345                 350         


Pro Phe Ile Arg Phe Arg Ile Asp Leu Gly Cys Leu Glu Leu Ala Ser 
        355                 360                 365             


Tyr Pro Lys Lys Met Gly Glu Glu Asn Asn Tyr Glu Arg Ser Val Thr 
    370                 375                 380                 


Asp His Ala Met Ala Phe Gly Arg Leu Thr Asp Phe His Asn Glu Asp 
385                 390                 395                 400 


Ala Val Leu Gln Gln Ile Thr Lys Gly Ile Thr Asp Glu Val Arg Phe 
                405                 410                 415     


Ser Leu Tyr Ala Pro Arg Tyr Ala Ile Tyr Asn Asn Lys Ile Gly Phe 
            420                 425                 430         


Val Arg Thr Ser Gly Ser Asp Lys Ile Ser Phe Pro Thr Leu Lys Lys 
        435                 440                 445             


Lys Gly Gly Glu Gly His Cys Val Ala Tyr Thr Leu Gln Asn Thr Lys 
    450                 455                 460                 


Ser Phe Gly Phe Ile Ser Ile Tyr Asp Leu Arg Lys Ile Leu Leu Leu 
465                 470                 475                 480 


Ser Phe Leu Asp Lys Asp Lys Ala Lys Asn Ile Val Ser Gly Leu Leu 
                485                 490                 495     


Glu Gln Cys Glu Lys His Trp Lys Asp Leu Ser Glu Asn Leu Phe Asp 
            500                 505                 510         


Ala Ile Arg Thr Glu Leu Gln Lys Glu Phe Pro Val Pro Leu Ile Arg 
        515                 520                 525             


Tyr Thr Leu Pro Arg Ser Lys Gly Gly Lys Leu Val Ser Ser Lys Leu 
    530                 535                 540                 


Ala Asp Lys Gln Glu Lys Tyr Glu Ser Glu Phe Glu Arg Arg Lys Glu 
545                 550                 555                 560 


Lys Leu Thr Glu Ile Leu Ser Glu Lys Asp Phe Asp Leu Ser Gln Ile 
                565                 570                 575     


Pro Arg Arg Met Ile Asp Glu Trp Leu Asn Val Leu Pro Thr Ser Arg 
            580                 585                 590         


Glu Lys Lys Leu Lys Gly Tyr Val Glu Thr Leu Lys Leu Asp Cys Arg 
        595                 600                 605             


Glu Arg Leu Arg Val Phe Glu Lys Arg Glu Lys Gly Glu His Pro Leu 
    610                 615                 620                 


Pro Pro Arg Ile Gly Glu Met Ala Thr Asp Leu Ala Lys Asp Ile Ile 
625                 630                 635                 640 


Arg Met Val Ile Asp Gln Gly Val Lys Gln Arg Ile Thr Ser Ala Tyr 
                645                 650                 655     


Tyr Ser Glu Ile Gln Arg Cys Leu Ala Gln Tyr Ala Gly Asp Asp Asn 
            660                 665                 670         


Arg Arg His Leu Asp Ser Ile Ile Arg Glu Leu Arg Leu Lys Asp Thr 
        675                 680                 685             


Lys Asn Gly His Pro Phe Leu Gly Lys Val Leu Arg Pro Gly Leu Gly 
    690                 695                 700                 


His Thr Glu Lys Leu Tyr Gln Arg Tyr Phe Glu Glu Lys Lys Glu Trp 
705                 710                 715                 720 


Leu Glu Ala Thr Phe Tyr Pro Ala Ala Ser Pro Lys Arg Val Pro Arg 
                725                 730                 735     


Phe Val Asn Pro Pro Thr Gly Lys Gln Lys Glu Leu Pro Leu Ile Ile 
            740                 745                 750         


Arg Asn Leu Met Lys Glu Arg Pro Glu Trp Arg Asp Trp Lys Gln Arg 
        755                 760                 765             


Lys Asn Ser His Pro Ile Asp Leu Pro Ser Gln Leu Phe Glu Asn Glu 
    770                 775                 780                 


Ile Cys Arg Leu Leu Lys Asp Lys Ile Gly Lys Glu Pro Ser Gly Lys 
785                 790                 795                 800 


Leu Lys Trp Asn Glu Met Phe Lys Leu Tyr Trp Asp Lys Glu Phe Pro 
                805                 810                 815     


Asn Gly Met Gln Arg Phe Tyr Arg Cys Lys Arg Arg Val Glu Val Phe 
            820                 825                 830         


Asp Lys Val Val Glu Tyr Glu Tyr Ser Glu Glu Gly Gly Asn Tyr Lys 
        835                 840                 845             


Lys Tyr Tyr Glu Ala Leu Ile Asp Glu Val Val Arg Gln Lys Ile Ser 
    850                 855                 860                 


Ser Ser Lys Glu Lys Ser Lys Leu Gln Val Glu Asp Leu Thr Leu Ser 
865                 870                 875                 880 


Val Arg Arg Val Phe Lys Arg Ala Ile Asn Glu Lys Glu Tyr Gln Leu 
                885                 890                 895     


Arg Leu Leu Cys Glu Asp Asp Arg Leu Leu Phe Met Ala Val Arg Asp 
            900                 905                 910         


Leu Tyr Asp Trp Lys Glu Ala Gln Leu Asp Leu Asp Lys Ile Asp Asn 
        915                 920                 925             


Met Leu Gly Glu Pro Val Ser Val Ser Gln Val Ile Gln Leu Glu Gly 
    930                 935                 940                 


Gly Gln Pro Asp Ala Val Ile Lys Ala Glu Cys Lys Leu Lys Asp Val 
945                 950                 955                 960 


Ser Lys Leu Met Arg Tyr Cys Tyr Asp Gly Arg Val Lys Gly Leu Met 
                965                 970                 975     


Pro Tyr Phe Ala Asn His Glu Ala Thr Gln Glu Gln Val Glu Met Glu 
            980                 985                 990         


Leu Arg His Tyr Glu Asp His Arg  Arg Arg Val Phe Asn  Trp Val Phe 
        995                 1000                 1005             


Ala Leu  Glu Lys Ser Val Leu  Lys Asn Glu Lys Leu  Arg Arg Phe 
    1010                 1015                 1020             


Tyr Glu  Glu Ser Gln Gly Gly  Cys Glu His Arg Arg  Cys Ile Asp 
    1025                 1030                 1035             


Ala Leu  Arg Lys Ala Ser Leu  Val Ser Glu Glu Glu  Tyr Glu Phe 
    1040                 1045                 1050             


Leu Val  His Ile Arg Asn Lys  Ser Ala His Asn Gln  Phe Pro Asp 
    1055                 1060                 1065             


Leu Glu  Ile Gly Lys Leu Pro  Pro Asn Val Thr Ser  Gly Phe Cys 
    1070                 1075                 1080             


Glu Cys  Ile Trp Ser Lys Tyr  Lys Ala Ile Ile Cys  Arg Ile Ile 
    1085                 1090                 1095             


Pro Phe  Ile Asp Pro Glu Arg  Arg Phe Phe Gly Lys  Leu Leu Glu 
    1100                 1105                 1110             


Gln Lys  
    1115 


<210> 216
<211> 668
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 216
Met Thr Glu Lys Lys Ser Ile Ile Phe Lys Asn Lys Ser Ser Val Glu 
1               5                   10                  15      


Ile Val Lys Lys Asp Ile Phe Ser Gln Thr Pro Asp Asn Met Ile Arg 
            20                  25                  30          


Asn Tyr Lys Ile Thr Leu Lys Ile Ser Glu Lys Asn Pro Arg Val Val 
        35                  40                  45              


Glu Ala Glu Ile Glu Asp Leu Met Asn Ser Thr Ile Leu Lys Asp Gly 
    50                  55                  60                  


Arg Arg Ser Ala Arg Arg Glu Lys Ser Met Thr Glu Arg Lys Leu Ile 
65                  70                  75                  80  


Glu Glu Lys Val Ala Glu Asn Tyr Ser Leu Leu Ala Asn Cys Pro Met 
                85                  90                  95      


Glu Glu Val Asp Ser Ile Lys Ile Tyr Lys Ile Lys Arg Phe Leu Thr 
            100                 105                 110         


Tyr Arg Ser Asn Met Leu Leu Tyr Phe Ala Ser Ile Asn Ser Phe Leu 
        115                 120                 125             


Cys Glu Gly Ile Lys Gly Lys Asp Asn Glu Thr Glu Glu Ile Trp His 
    130                 135                 140                 


Leu Lys Asp Asn Asp Val Arg Lys Glu Lys Val Lys Glu Asn Phe Lys 
145                 150                 155                 160 


Asn Lys Leu Ile Gln Ser Thr Glu Asn Tyr Asn Ser Ser Leu Lys Asn 
                165                 170                 175     


Gln Ile Glu Glu Lys Glu Lys Leu Leu Arg Lys Glu Ser Lys Lys Gly 
            180                 185                 190         


Ala Phe Tyr Arg Thr Ile Ile Lys Lys Leu Gln Gln Glu Arg Ile Lys 
        195                 200                 205             


Glu Leu Ser Glu Lys Ser Leu Thr Glu Asp Cys Glu Lys Ile Ile Lys 
    210                 215                 220                 


Leu Tyr Ser Glu Leu Arg His Pro Leu Met His Tyr Asp Tyr Gln Tyr 
225                 230                 235                 240 


Phe Glu Asn Leu Phe Glu Asn Lys Glu Asn Ser Glu Leu Thr Lys Asn 
                245                 250                 255     


Leu Asn Leu Asp Ile Phe Lys Ser Leu Pro Leu Val Arg Lys Met Lys 
            260                 265                 270         


Leu Asn Asn Lys Val Asn Tyr Leu Glu Asp Asn Asp Thr Leu Phe Val 
        275                 280                 285             


Leu Gln Lys Thr Lys Lys Ala Lys Thr Leu Tyr Gln Ile Tyr Asp Ala 
    290                 295                 300                 


Leu Cys Glu Gln Lys Asn Gly Phe Asn Lys Phe Ile Asn Asp Phe Phe 
305                 310                 315                 320 


Val Ser Asp Gly Glu Glu Asn Thr Val Phe Lys Gln Ile Ile Asn Glu 
                325                 330                 335     


Lys Phe Gln Ser Glu Met Glu Phe Leu Glu Lys Arg Ile Ser Glu Ser 
            340                 345                 350         


Glu Lys Lys Asn Glu Lys Leu Lys Lys Lys Phe Asp Ser Met Lys Ala 
        355                 360                 365             


His Phe His Asn Ile Asn Ser Glu Asp Thr Lys Glu Ala Tyr Phe Trp 
    370                 375                 380                 


Asp Ile His Ser Ser Ser Asn Tyr Lys Thr Lys Tyr Asn Glu Arg Lys 
385                 390                 395                 400 


Asn Leu Val Asn Glu Tyr Thr Glu Leu Leu Gly Ser Ser Lys Glu Lys 
                405                 410                 415     


Lys Leu Leu Arg Glu Glu Ile Thr Gln Ile Asn Arg Lys Leu Leu Lys 
            420                 425                 430         


Leu Lys Gln Glu Met Glu Glu Ile Thr Lys Lys Asn Ser Leu Phe Arg 
        435                 440                 445             


Leu Glu Tyr Lys Met Lys Ile Ala Phe Gly Phe Leu Phe Cys Glu Phe 
    450                 455                 460                 


Asp Gly Asn Ile Ser Lys Phe Lys Asp Glu Phe Asp Ala Ser Asn Gln 
465                 470                 475                 480 


Glu Lys Ile Ile Gln Tyr His Lys Asn Gly Glu Lys Tyr Leu Thr Tyr 
                485                 490                 495     


Phe Leu Lys Glu Glu Glu Lys Glu Lys Phe Asn Leu Glu Lys Met Gln 
            500                 505                 510         


Lys Ile Ile Gln Lys Thr Glu Glu Glu Asp Trp Leu Leu Pro Glu Thr 
        515                 520                 525             


Lys Asn Asn Leu Phe Lys Phe Tyr Leu Leu Thr Tyr Leu Leu Leu Pro 
    530                 535                 540                 


Tyr Glu Leu Lys Gly Asp Phe Leu Gly Phe Val Lys Lys His Tyr Tyr 
545                 550                 555                 560 


Asp Ile Lys Asn Val Asp Phe Met Asp Glu Asn Gln Asn Asn Ile Gln 
                565                 570                 575     


Val Ser Gln Thr Val Glu Lys Gln Glu Asp Tyr Phe Tyr His Lys Ile 
            580                 585                 590         


Arg Leu Phe Glu Lys Asn Thr Lys Lys Tyr Glu Ile Val Lys Tyr Ser 
        595                 600                 605             


Ile Val Pro Asn Glu Lys Leu Lys Gln Tyr Phe Glu Asp Leu Gly Ile 
    610                 615                 620                 


Asp Ile Lys Tyr Leu Thr Gly Ser Val Glu Ser Gly Glu Lys Trp Leu 
625                 630                 635                 640 


Gly Glu Asn Leu Gly Ile Asp Ile Lys Tyr Leu Thr Val Glu Gln Lys 
                645                 650                 655     


Ser Glu Val Ser Glu Glu Lys Ile Lys Lys Phe Leu 
            660                 665             


<210> 217
<211> 796
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 217
Met Glu Lys Asp Lys Lys Gly Glu Lys Ile Asp Ile Ser Gln Glu Met 
1               5                   10                  15      


Ile Glu Glu Asp Leu Arg Lys Ile Leu Ile Leu Phe Ser Arg Leu Arg 
            20                  25                  30          


His Ser Met Val His Tyr Asp Tyr Glu Phe Tyr Gln Ala Leu Tyr Ser 
        35                  40                  45              


Gly Lys Asp Phe Val Ile Ser Asp Lys Asn Asn Leu Glu Asn Arg Met 
    50                  55                  60                  


Ile Ser Gln Leu Leu Asp Leu Asn Ile Phe Lys Glu Leu Ser Lys Val 
65                  70                  75                  80  


Lys Leu Ile Lys Asp Lys Ala Ile Ser Asn Tyr Leu Asp Lys Asn Thr 
                85                  90                  95      


Thr Ile His Val Leu Gly Gln Asp Ile Lys Ala Ile Arg Leu Leu Asp 
            100                 105                 110         


Ile Tyr Arg Asp Ile Cys Gly Ser Lys Asn Gly Phe Asn Lys Phe Ile 
        115                 120                 125             


Asn Thr Met Ile Thr Ile Ser Gly Glu Glu Asp Arg Glu Tyr Lys Glu 
    130                 135                 140                 


Lys Val Ile Glu His Phe Asn Lys Lys Met Glu Asn Leu Ser Thr Tyr 
145                 150                 155                 160 


Leu Glu Lys Leu Glu Lys Gln Asp Asn Ala Lys Arg Asn Asn Lys Arg 
                165                 170                 175     


Val Tyr Asn Leu Leu Lys Gln Lys Leu Ile Glu Gln Gln Lys Leu Lys 
            180                 185                 190         


Glu Trp Phe Gly Gly Pro Tyr Val Tyr Asp Ile His Ser Ser Lys Arg 
        195                 200                 205             


Tyr Lys Glu Leu Tyr Ile Glu Arg Lys Lys Leu Val Asp Arg His Ser 
    210                 215                 220                 


Lys Leu Phe Glu Glu Gly Leu Asp Glu Lys Asn Lys Lys Glu Leu Thr 
225                 230                 235                 240 


Lys Ile Asn Asp Glu Leu Ser Lys Leu Asn Ser Glu Met Lys Glu Met 
                245                 250                 255     


Thr Lys Leu Asn Ser Lys Tyr Arg Leu Gln Tyr Lys Leu Gln Leu Ala 
            260                 265                 270         


Phe Gly Phe Ile Leu Glu Glu Phe Asp Leu Asn Ile Asp Thr Phe Ile 
        275                 280                 285             


Asn Asn Phe Asp Lys Asp Lys Asp Leu Ile Ile Ser Asn Phe Met Lys 
    290                 295                 300                 


Lys Arg Asp Ile Tyr Leu Asn Arg Val Leu Asp Arg Gly Asp Asn Arg 
305                 310                 315                 320 


Leu Lys Asn Ile Ile Lys Glu Tyr Lys Phe Arg Asp Thr Glu Asp Ile 
                325                 330                 335     


Phe Cys Asn Asp Arg Asp Asn Asn Leu Val Lys Leu Tyr Ile Leu Met 
            340                 345                 350         


Tyr Ile Leu Leu Pro Val Glu Ile Arg Gly Asp Phe Leu Gly Phe Val 
        355                 360                 365             


Lys Lys Asn Tyr Tyr Asp Met Lys His Val Asp Phe Ile Asp Lys Lys 
    370                 375                 380                 


Asp Lys Glu Asp Lys Asp Thr Phe Phe His Asp Leu Arg Leu Phe Glu 
385                 390                 395                 400 


Lys Asn Ile Arg Lys Leu Glu Ile Thr Asp Tyr Ser Leu Ser Ser Gly 
                405                 410                 415     


Phe Leu Ser Lys Glu His Lys Val Asp Ile Glu Lys Lys Ile Asn Asp 
            420                 425                 430         


Phe Ile Asn Arg Asn Gly Ala Met Lys Leu Pro Glu Asp Ile Thr Ile 
        435                 440                 445             


Glu Glu Phe Asn Lys Ser Leu Ile Leu Pro Ile Met Lys Asn Tyr Gln 
    450                 455                 460                 


Ile Asn Phe Lys Leu Leu Asn Asp Ile Glu Ile Ser Ala Leu Phe Lys 
465                 470                 475                 480 


Ile Ala Lys Asp Arg Ser Ile Thr Phe Lys Gln Ala Ile Asp Glu Ile 
                485                 490                 495     


Lys Asn Glu Asp Ile Lys Lys Asn Ser Lys Lys Asn Asp Lys Asn Asn 
            500                 505                 510         


His Lys Asp Lys Asn Ile Asn Phe Thr Gln Leu Met Lys Arg Ala Leu 
        515                 520                 525             


His Glu Lys Ile Pro Tyr Lys Ala Gly Met Tyr Gln Ile Arg Asn Asn 
    530                 535                 540                 


Ile Ser His Ile Asp Met Glu Gln Leu Tyr Ile Asp Pro Leu Asn Ser 
545                 550                 555                 560 


Tyr Met Asn Ser Asn Lys Asn Asn Ile Thr Ile Ser Glu Gln Ile Glu 
                565                 570                 575     


Lys Ile Ile Asp Val Cys Val Thr Gly Gly Val Thr Gly Lys Glu Leu 
            580                 585                 590         


Asn Asn Asn Ile Ile Asn Asp Tyr Tyr Met Lys Lys Glu Lys Leu Val 
        595                 600                 605             


Phe Asn Leu Lys Leu Arg Lys Gln Asn Asp Ile Val Ser Ile Glu Ser 
    610                 615                 620                 


Gln Glu Lys Asn Lys Arg Glu Glu Phe Val Phe Lys Lys Tyr Gly Leu 
625                 630                 635                 640 


Asp Tyr Lys Asp Gly Glu Ile Asn Ile Ile Glu Val Ile Gln Lys Val 
                645                 650                 655     


Asn Ser Leu Gln Glu Glu Leu Arg Asn Ile Lys Glu Thr Ser Lys Glu 
            660                 665                 670         


Lys Leu Lys Asn Lys Glu Thr Leu Phe Arg Asp Ile Ser Leu Ile Asn 
        675                 680                 685             


Gly Thr Ile Arg Lys Asn Ile Asn Phe Lys Ile Lys Glu Met Val Leu 
    690                 695                 700                 


Asp Ile Val Arg Met Asp Glu Ile Arg His Ile Asn Ile His Ile Tyr 
705                 710                 715                 720 


Tyr Lys Gly Glu Asn Tyr Thr Arg Ser Asn Ile Ile Lys Phe Lys Tyr 
                725                 730                 735     


Ala Ile Asp Gly Glu Asn Lys Lys Tyr Tyr Leu Lys Gln His Glu Ile 
            740                 745                 750         


Asn Asp Ile Asn Leu Glu Leu Lys Asp Lys Phe Val Thr Leu Ile Cys 
        755                 760                 765             


Asn Met Asp Lys His Pro Asn Lys Asn Lys Gln Thr Ile Asn Leu Glu 
    770                 775                 780                 


Ser Asn Tyr Ile Gln Asn Val Lys Phe Ile Ile Pro 
785                 790                 795     


<210> 218
<211> 897
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 218
Met Glu Asn Lys Gly Asn Asn Lys Lys Ile Asp Phe Asp Glu Asn Tyr 
1               5                   10                  15      


Asn Ile Leu Val Ala Gln Ile Lys Glu Tyr Phe Thr Lys Glu Ile Glu 
            20                  25                  30          


Asn Tyr Asn Asn Arg Ile Asp Asn Ile Ile Asp Lys Lys Glu Leu Leu 
        35                  40                  45              


Lys Tyr Ser Glu Lys Lys Glu Glu Ser Glu Lys Asn Lys Lys Leu Glu 
    50                  55                  60                  


Glu Leu Asn Lys Leu Lys Ser Gln Lys Leu Lys Ile Leu Thr Asp Glu 
65                  70                  75                  80  


Glu Ile Lys Ala Asp Val Ile Lys Ile Ile Lys Ile Phe Ser Asp Leu 
                85                  90                  95      


Arg His Ser Leu Met His Tyr Glu Tyr Lys Tyr Phe Glu Asn Leu Phe 
            100                 105                 110         


Glu Asn Lys Lys Asn Glu Glu Leu Ala Glu Leu Leu Asn Leu Asn Leu 
        115                 120                 125             


Phe Lys Asn Leu Thr Leu Leu Arg Gln Met Lys Ile Glu Asn Lys Thr 
    130                 135                 140                 


Asn Tyr Leu Glu Gly Arg Glu Glu Phe Asn Ile Ile Gly Lys Asn Ile 
145                 150                 155                 160 


Lys Ala Lys Glu Val Leu Gly His Tyr Asn Leu Leu Ala Glu Gln Lys 
                165                 170                 175     


Asn Gly Phe Asn Asn Phe Ile Asn Ser Phe Phe Val Gln Asp Gly Thr 
            180                 185                 190         


Glu Asn Leu Glu Phe Lys Lys Leu Ile Asp Glu His Phe Val Asn Ala 
        195                 200                 205             


Lys Lys Arg Leu Glu Arg Asn Ile Lys Lys Ser Lys Lys Leu Glu Lys 
    210                 215                 220                 


Glu Leu Glu Lys Met Glu Gln His Tyr Gln Arg Leu Asn Cys Ala Tyr 
225                 230                 235                 240 


Val Trp Asp Ile His Thr Ser Thr Thr Tyr Lys Lys Leu Tyr Asn Lys 
                245                 250                 255     


Arg Lys Ser Leu Ile Glu Glu Tyr Asn Lys Gln Ile Asn Glu Ile Lys 
            260                 265                 270         


Asp Lys Glu Val Ile Thr Ala Ile Asn Val Glu Leu Leu Arg Ile Lys 
        275                 280                 285             


Lys Glu Met Glu Glu Ile Thr Lys Ser Asn Ser Leu Phe Arg Leu Lys 
    290                 295                 300                 


Tyr Lys Met Gln Ile Ala Tyr Ala Phe Leu Glu Ile Glu Phe Gly Gly 
305                 310                 315                 320 


Asn Ile Ala Lys Phe Lys Asp Glu Phe Asp Cys Ser Lys Met Glu Glu 
                325                 330                 335     


Val Gln Lys Tyr Leu Lys Lys Gly Val Lys Tyr Leu Lys Tyr Tyr Lys 
            340                 345                 350         


Asp Lys Glu Ala Gln Lys Asn Tyr Glu Phe Pro Phe Glu Glu Ile Phe 
        355                 360                 365             


Glu Asn Lys Asp Thr His Asn Glu Glu Trp Leu Glu Asn Thr Ser Glu 
    370                 375                 380                 


Asn Asn Leu Phe Lys Phe Tyr Ile Leu Thr Tyr Leu Leu Leu Pro Met 
385                 390                 395                 400 


Glu Phe Lys Gly Asp Phe Leu Gly Val Val Lys Lys His Tyr Tyr Asp 
                405                 410                 415     


Ile Lys Asn Val Asp Phe Thr Asp Glu Ser Glu Lys Glu Leu Ser Gln 
            420                 425                 430         


Val Gln Leu Asp Lys Met Ile Gly Asp Ser Phe Phe His Lys Ile Arg 
        435                 440                 445             


Leu Phe Glu Lys Asn Thr Lys Arg Tyr Glu Ile Ile Lys Tyr Ser Ile 
    450                 455                 460                 


Leu Thr Ser Asp Glu Ile Lys Arg Tyr Phe Arg Leu Leu Glu Leu Asp 
465                 470                 475                 480 


Val Pro Tyr Phe Glu Tyr Glu Lys Gly Thr Asp Glu Ile Gly Ile Phe 
                485                 490                 495     


Asn Lys Asn Ile Ile Leu Thr Ile Phe Lys Tyr Tyr Gln Ile Ile Phe 
            500                 505                 510         


Arg Leu Tyr Asn Asp Leu Glu Ile His Gly Leu Phe Asn Ile Ser Ser 
        515                 520                 525             


Asp Leu Asp Lys Ile Leu Arg Asp Leu Lys Ser Tyr Gly Asn Lys Asn 
    530                 535                 540                 


Ile Asn Phe Arg Glu Phe Leu Tyr Val Ile Lys Gln Asn Asn Asn Ser 
545                 550                 555                 560 


Ser Thr Glu Glu Glu Tyr Arg Lys Ile Trp Glu Asn Leu Glu Ala Lys 
                565                 570                 575     


Tyr Leu Arg Leu His Leu Leu Thr Pro Glu Lys Glu Glu Ile Lys Thr 
            580                 585                 590         


Lys Thr Lys Glu Glu Leu Glu Lys Leu Asn Glu Ile Ser Asn Leu Arg 
        595                 600                 605             


Asn Gly Ile Cys His Leu Asn Tyr Lys Glu Ile Ile Glu Glu Ile Leu 
    610                 615                 620                 


Lys Thr Glu Ile Ser Glu Lys Asn Lys Glu Ala Thr Leu Asn Glu Lys 
625                 630                 635                 640 


Ile Arg Lys Val Ile Asn Phe Ile Lys Glu Asn Glu Leu Asp Lys Val 
                645                 650                 655     


Glu Leu Gly Phe Asn Phe Ile Asn Asp Phe Phe Met Lys Lys Glu Gln 
            660                 665                 670         


Phe Met Phe Gly Gln Ile Lys Gln Val Lys Glu Gly Asn Ser Asp Ser 
        675                 680                 685             


Ile Thr Thr Glu Arg Glu Arg Lys Glu Lys Asn Asn Lys Lys Leu Lys 
    690                 695                 700                 


Glu Thr Tyr Glu Leu Asn Cys Asp Asn Leu Ser Glu Phe Tyr Glu Thr 
705                 710                 715                 720 


Ser Asn Asn Leu Arg Glu Arg Ala Asn Ser Ser Ser Leu Leu Glu Asp 
                725                 730                 735     


Ser Ala Phe Leu Lys Lys Ile Gly Leu Tyr Lys Val Lys Asn Asn Lys 
            740                 745                 750         


Val Asn Ser Lys Val Lys Asp Glu Glu Lys Arg Ile Glu Asn Ile Lys 
        755                 760                 765             


Arg Lys Leu Leu Lys Asp Ser Ser Asp Ile Met Gly Met Tyr Lys Ala 
    770                 775                 780                 


Glu Val Val Lys Lys Leu Lys Glu Lys Leu Ile Leu Ile Phe Lys His 
785                 790                 795                 800 


Asp Glu Glu Lys Arg Ile Tyr Val Thr Val Tyr Asp Thr Ser Lys Ala 
                805                 810                 815     


Val Pro Glu Asn Ile Ser Lys Glu Ile Leu Val Lys Arg Asn Asn Ser 
            820                 825                 830         


Lys Glu Glu Tyr Phe Phe Glu Asp Asn Asn Lys Lys Tyr Val Thr Glu 
        835                 840                 845             


Tyr Tyr Thr Leu Glu Ile Thr Glu Thr Asn Glu Leu Lys Val Ile Pro 
    850                 855                 860                 


Ala Lys Lys Leu Glu Gly Lys Glu Phe Lys Thr Glu Lys Asn Lys Glu 
865                 870                 875                 880 


Asn Lys Leu Met Leu Asn Asn His Tyr Cys Phe Asn Val Lys Ile Ile 
                885                 890                 895     


Tyr 
    


<210> 219
<211> 919
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 219
Met Glu Glu Ile Lys His Lys Lys Asn Lys Ser Ser Ile Ile Arg Val 
1               5                   10                  15      


Ile Val Ser Asn Tyr Asp Met Thr Gly Ile Lys Glu Ile Lys Val Leu 
            20                  25                  30          


Tyr Gln Lys Gln Gly Gly Val Asp Thr Phe Asn Leu Lys Thr Ile Ile 
        35                  40                  45              


Asn Leu Glu Ser Gly Asn Leu Glu Ile Ile Ser Cys Lys Pro Lys Glu 
    50                  55                  60                  


Arg Glu Lys Tyr Arg Tyr Glu Phe Asn Cys Lys Thr Glu Ile Asn Thr 
65                  70                  75                  80  


Ile Ser Ile Thr Lys Lys Asp Lys Val Leu Lys Lys Glu Ile Arg Lys 
                85                  90                  95      


Tyr Ser Leu Glu Leu Tyr Phe Lys Asn Glu Lys Lys Asp Thr Val Val 
            100                 105                 110         


Ala Lys Val Thr Asp Leu Leu Lys Ala Pro Asp Lys Ile Glu Gly Glu 
        115                 120                 125             


Arg Asn His Leu Arg Lys Leu Ser Ser Ser Thr Glu Arg Lys Leu Leu 
    130                 135                 140                 


Ser Lys Thr Leu Cys Lys Asn Tyr Ser Glu Ile Ser Lys Thr Pro Ile 
145                 150                 155                 160 


Glu Glu Ile Asp Ser Ile Lys Ile Tyr Lys Ile Lys Arg Phe Leu Asn 
                165                 170                 175     


Tyr Arg Ser Asn Phe Leu Ile Tyr Phe Ala Leu Ile Asn Asp Phe Leu 
            180                 185                 190         


Cys Ala Gly Val Lys Glu Asp Asp Ile Asn Glu Val Trp Leu Ile Gln 
        195                 200                 205             


Asp Lys Glu His Thr Ala Phe Leu Glu Asn Arg Ile Glu Lys Ile Thr 
    210                 215                 220                 


Asp Tyr Ile Phe Asp Lys Leu Ser Lys Asp Ile Glu Asn Lys Lys Asn 
225                 230                 235                 240 


Gln Phe Glu Lys Arg Ile Lys Lys Tyr Lys Thr Ser Leu Glu Glu Leu 
                245                 250                 255     


Lys Thr Glu Thr Leu Glu Lys Asn Lys Thr Phe Tyr Ile Asp Ser Ile 
            260                 265                 270         


Lys Thr Lys Ile Thr Asn Leu Glu Asn Lys Ile Thr Glu Leu Ser Leu 
        275                 280                 285             


Tyr Asn Ser Lys Glu Ser Leu Lys Glu Asp Leu Ile Lys Ile Ile Ser 
    290                 295                 300                 


Ile Phe Thr Asn Leu Arg His Ser Leu Met His Tyr Asp Tyr Lys Ser 
305                 310                 315                 320 


Phe Glu Asn Leu Phe Glu Asn Ile Glu Asn Glu Glu Leu Lys Asn Leu 
                325                 330                 335     


Leu Asp Leu Asn Leu Phe Lys Ser Ile Arg Met Ser Asp Glu Phe Lys 
            340                 345                 350         


Thr Lys Asn Arg Thr Asn Tyr Leu Asp Gly Thr Glu Ser Phe Thr Ile 
        355                 360                 365             


Val Lys Lys His Gln Asn Leu Lys Lys Leu Tyr Thr Tyr Tyr Asn Asn 
    370                 375                 380                 


Leu Cys Asp Lys Lys Asn Gly Phe Asn Thr Phe Ile Asn Ser Phe Phe 
385                 390                 395                 400 


Val Thr Asp Gly Ile Glu Asn Thr Asp Phe Lys Asn Leu Ile Ile Leu 
                405                 410                 415     


His Phe Glu Lys Glu Met Glu Glu Tyr Lys Lys Ser Ile Glu Tyr Tyr 
            420                 425                 430         


Lys Ile Lys Ile Ser Asn Glu Lys Asn Lys Ser Lys Lys Glu Lys Leu 
        435                 440                 445             


Lys Glu Lys Ile Asp Leu Leu Gln Ser Glu Leu Ile Asn Met Arg Glu 
    450                 455                 460                 


His Lys Asn Leu Leu Lys Gln Ile Tyr Phe Phe Asp Ile His Asn Ser 
465                 470                 475                 480 


Ile Lys Tyr Lys Glu Leu Tyr Ser Glu Arg Lys Asn Leu Ile Glu Gln 
                485                 490                 495     


Tyr Asn Leu Gln Ile Asn Gly Val Lys Asp Val Thr Ala Ile Asn His 
            500                 505                 510         


Ile Asn Thr Lys Leu Leu Ser Leu Lys Asn Lys Met Asp Lys Ile Thr 
        515                 520                 525             


Lys Gln Asn Ser Leu Tyr Arg Leu Lys Tyr Lys Leu Lys Ile Ala Tyr 
    530                 535                 540                 


Ser Phe Leu Met Ile Glu Phe Asp Gly Asp Val Ser Lys Phe Lys Asn 
545                 550                 555                 560 


Asn Phe Asp Pro Thr Asn Leu Glu Lys Arg Val Glu Tyr Leu Asp Lys 
                565                 570                 575     


Lys Glu Glu Tyr Leu Asn Tyr Thr Ala Pro Lys Asn Lys Phe Asn Phe 
            580                 585                 590         


Ala Lys Leu Glu Glu Glu Leu Gln Lys Ile Gln Ser Thr Ser Glu Met 
        595                 600                 605             


Gly Ala Asp Tyr Leu Asn Val Ser Pro Glu Asn Asn Leu Phe Lys Phe 
    610                 615                 620                 


Tyr Ile Leu Thr Tyr Ile Met Leu Pro Val Glu Phe Lys Gly Asp Phe 
625                 630                 635                 640 


Leu Gly Phe Val Lys Asn His Tyr Tyr Asn Ile Lys Asn Val Asp Phe 
                645                 650                 655     


Met Asp Glu Ser Leu Leu Asp Glu Asn Glu Val Asp Ser Asn Lys Leu 
            660                 665                 670         


Asn Glu Lys Ile Glu Asn Leu Lys Asp Ser Ser Phe Phe Asn Lys Ile 
        675                 680                 685             


Arg Leu Phe Glu Lys Asn Ile Lys Lys Tyr Glu Ile Val Lys Tyr Ser 
    690                 695                 700                 


Val Ser Thr Gln Glu Asn Met Lys Glu Tyr Phe Lys Gln Leu Asn Leu 
705                 710                 715                 720 


Asp Ile Pro Tyr Leu Asp Tyr Lys Ser Thr Asp Glu Ile Gly Ile Phe 
                725                 730                 735     


Asn Lys Asn Met Ile Leu Pro Ile Phe Lys Tyr Tyr Gln Asn Val Phe 
            740                 745                 750         


Lys Leu Cys Asn Asp Ile Glu Ile His Ala Leu Leu Ala Leu Ala Asn 
        755                 760                 765             


Lys Lys Gln Gln Asn Leu Glu Tyr Ala Ile Tyr Cys Cys Ser Lys Lys 
    770                 775                 780                 


Asn Ser Leu Asn Tyr Asn Glu Leu Leu Lys Thr Phe Asn Arg Lys Thr 
785                 790                 795                 800 


Tyr Gln Asn Leu Ser Phe Ile Arg Asn Lys Ile Ala His Leu Asn Tyr 
                805                 810                 815     


Lys Glu Leu Phe Ser Asp Leu Phe Asn Asn Glu Leu Asp Leu Asn Thr 
            820                 825                 830         


Lys Val Arg Cys Leu Ile Glu Phe Ser Gln Asn Asn Lys Phe Asp Gln 
        835                 840                 845             


Ile Asp Leu Gly Met Asn Phe Ile Asn Asp Tyr Tyr Met Lys Lys Thr 
    850                 855                 860                 


Arg Phe Ile Phe Asn Gln Arg Arg Leu Arg Asp Leu Asn Val Pro Ser 
865                 870                 875                 880 


Lys Glu Lys Ile Ile Asp Gly Lys Arg Lys Gln Gln Asn Asp Ser Asn 
                885                 890                 895     


Asn Glu Leu Leu Lys Lys Tyr Gly Leu Ser Arg Thr Asn Ile Lys Asp 
            900                 905                 910         


Ile Phe Asn Lys Ala Trp Tyr 
        915                 


<210> 220
<211> 1110
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 220
Met Lys Val Arg Tyr Arg Lys Gln Ala Gln Leu Asp Thr Phe Ile Ile 
1               5                   10                  15      


Lys Thr Glu Ile Val Asn Asn Asp Ile Phe Ile Lys Ser Ile Ile Glu 
            20                  25                  30          


Lys Ala Arg Glu Lys Tyr Arg Tyr Ser Phe Leu Phe Asp Gly Glu Glu 
        35                  40                  45              


Lys Tyr His Phe Lys Asn Lys Ser Ser Val Glu Ile Val Lys Asn Asp 
    50                  55                  60                  


Ile Phe Ser Gln Thr Pro Asp Asn Met Ile Arg Asn Tyr Lys Ile Thr 
65                  70                  75                  80  


Leu Lys Ile Ser Glu Lys Asn Pro Arg Val Val Glu Ala Glu Ile Glu 
                85                  90                  95      


Asp Leu Met Asn Ser Thr Ile Leu Lys Asp Gly Arg Arg Ser Ala Arg 
            100                 105                 110         


Arg Glu Lys Ser Met Thr Glu Arg Lys Leu Ile Glu Glu Lys Val Ala 
        115                 120                 125             


Glu Asn Tyr Ser Leu Leu Ala Asn Cys Pro Ile Glu Glu Val Asp Ser 
    130                 135                 140                 


Ile Lys Ile Tyr Lys Ile Lys Arg Phe Leu Thr Tyr Arg Ser Asn Met 
145                 150                 155                 160 


Leu Leu Tyr Phe Ala Ser Ile Asn Ser Phe Leu Cys Glu Gly Ile Lys 
                165                 170                 175     


Gly Lys Asp Asn Glu Thr Glu Glu Ile Trp His Leu Lys Asp Asn Asp 
            180                 185                 190         


Val Arg Lys Glu Lys Val Lys Glu Asn Phe Lys Asn Lys Leu Ile Gln 
        195                 200                 205             


Ser Thr Glu Asn Tyr Asn Ser Ser Leu Lys Asn Gln Ile Glu Glu Lys 
    210                 215                 220                 


Glu Lys Leu Ser Ser Lys Glu Phe Lys Lys Gly Ala Phe Tyr Arg Thr 
225                 230                 235                 240 


Ile Ile Lys Lys Leu Gln Gln Glu Arg Ile Lys Glu Leu Ser Glu Lys 
                245                 250                 255     


Ser Leu Thr Glu Asp Cys Glu Lys Ile Ile Lys Leu Tyr Ser Glu Leu 
            260                 265                 270         


Arg His Pro Leu Met His Tyr Asp Tyr Gln Tyr Phe Glu Asn Leu Phe 
        275                 280                 285             


Glu Asn Lys Glu Asn Ser Glu Leu Thr Lys Asn Leu Asn Leu Asp Ile 
    290                 295                 300                 


Phe Lys Ser Leu Pro Leu Val Arg Lys Met Lys Leu Asn Asn Lys Val 
305                 310                 315                 320 


Asn Tyr Leu Glu Asp Asn Asp Thr Leu Phe Val Leu Gln Lys Thr Lys 
                325                 330                 335     


Lys Ala Lys Thr Leu Tyr Gln Ile Tyr Asp Ala Leu Cys Glu Gln Lys 
            340                 345                 350         


Asn Gly Phe Asn Lys Phe Ile Asn Asp Phe Phe Val Ser Asp Gly Glu 
        355                 360                 365             


Glu Asn Thr Val Phe Lys Gln Ile Ile Asn Glu Lys Phe Gln Ser Glu 
    370                 375                 380                 


Met Glu Phe Leu Glu Lys Arg Ile Ser Glu Ser Glu Lys Lys Asn Glu 
385                 390                 395                 400 


Lys Leu Lys Lys Lys Leu Asp Ser Met Lys Ala His Phe Arg Asn Ile 
                405                 410                 415     


Asn Ser Glu Asp Thr Lys Glu Ala Tyr Phe Trp Asp Ile His Ser Ser 
            420                 425                 430         


Arg Asn Tyr Lys Thr Lys Tyr Asn Glu Arg Lys Asn Leu Val Asn Glu 
        435                 440                 445             


Tyr Thr Lys Leu Leu Gly Ser Ser Lys Glu Lys Lys Leu Leu Arg Glu 
    450                 455                 460                 


Glu Ile Thr Lys Ile Asn Arg Gln Leu Leu Lys Leu Lys Gln Glu Met 
465                 470                 475                 480 


Glu Glu Ile Thr Lys Lys Asn Ser Leu Phe Arg Leu Glu Tyr Lys Met 
                485                 490                 495     


Lys Ile Ala Phe Gly Phe Leu Phe Cys Glu Phe Asp Gly Asn Ile Ser 
            500                 505                 510         


Lys Phe Lys Asp Glu Phe Asp Ala Ser Asn Gln Glu Lys Ile Ile Gln 
        515                 520                 525             


Tyr His Lys Asn Gly Glu Lys Tyr Leu Thr Ser Phe Leu Lys Glu Glu 
    530                 535                 540                 


Glu Lys Glu Lys Phe Asn Leu Glu Lys Met Gln Lys Ile Ile Gln Lys 
545                 550                 555                 560 


Thr Glu Glu Glu Asp Trp Leu Leu Pro Glu Thr Lys Asn Asn Leu Phe 
                565                 570                 575     


Lys Phe Tyr Leu Leu Thr Tyr Leu Leu Leu Pro Tyr Glu Leu Lys Gly 
            580                 585                 590         


Asp Phe Leu Gly Phe Val Lys Lys His Tyr Tyr Asp Ile Lys Asn Val 
        595                 600                 605             


Asp Phe Met Asp Glu Asn Gln Asn Asn Ile Gln Val Ser Gln Thr Val 
    610                 615                 620                 


Glu Lys Gln Glu Asp Tyr Phe Tyr His Lys Ile Arg Leu Phe Glu Lys 
625                 630                 635                 640 


Asn Thr Lys Lys Tyr Glu Ile Val Lys Tyr Ser Ile Val Pro Asn Glu 
                645                 650                 655     


Lys Leu Lys Gln Tyr Phe Glu Asp Leu Gly Ile Asp Ile Lys Tyr Leu 
            660                 665                 670         


Thr Gly Ser Val Glu Ser Gly Glu Lys Trp Leu Gly Glu Asn Leu Gly 
        675                 680                 685             


Ile Asp Ile Lys Tyr Leu Thr Val Glu Gln Lys Ser Glu Val Ser Glu 
    690                 695                 700                 


Glu Lys Asn Lys Lys Val Ser Leu Lys Asn Asn Gly Met Phe Asn Lys 
705                 710                 715                 720 


Thr Ile Leu Leu Phe Val Phe Lys Tyr Tyr Gln Ile Ala Phe Lys Leu 
                725                 730                 735     


Phe Asn Asp Ile Glu Leu Tyr Ser Leu Phe Phe Leu Arg Glu Lys Ser 
            740                 745                 750         


Glu Lys Pro Phe Glu Val Phe Leu Glu Glu Leu Lys Asp Lys Met Ile 
        755                 760                 765             


Gly Lys Gln Leu Asn Phe Gly Gln Leu Leu Tyr Val Val Tyr Glu Val 
    770                 775                 780                 


Leu Val Lys Asn Lys Asp Leu Asp Lys Ile Leu Ser Lys Lys Ile Asp 
785                 790                 795                 800 


Tyr Arg Lys Asp Lys Ser Phe Ser Pro Glu Ile Ala Tyr Leu Arg Asn 
                805                 810                 815     


Phe Leu Ser His Leu Asn Tyr Ser Lys Phe Leu Asp Asn Phe Met Lys 
            820                 825                 830         


Ile Asn Thr Asn Lys Ser Asp Glu Asn Lys Glu Val Leu Ile Pro Ser 
        835                 840                 845             


Ile Lys Ile Gln Lys Met Ile Gln Phe Ile Glu Lys Cys Asn Leu Gln 
    850                 855                 860                 


Asn Gln Ile Asp Phe Asp Phe Asn Phe Val Asn Asp Phe Tyr Met Arg 
865                 870                 875                 880 


Lys Glu Lys Met Phe Phe Ile Gln Leu Lys Gln Ile Phe Pro Asp Ile 
                885                 890                 895     


Asn Ser Thr Glu Lys Gln Lys Lys Ser Glu Lys Glu Glu Ile Leu Arg 
            900                 905                 910         


Lys Arg Tyr His Leu Ile Asn Lys Lys Asn Glu Gln Ile Lys Asp Glu 
        915                 920                 925             


His Glu Ala Gln Ser Gln Leu Tyr Glu Lys Ile Leu Ser Leu Gln Lys 
    930                 935                 940                 


Ile Phe Ser Cys Asp Lys Asn Asn Phe Tyr Arg Arg Leu Lys Glu Glu 
945                 950                 955                 960 


Lys Leu Leu Phe Leu Glu Lys Gln Gly Lys Lys Lys Ile Ser Met Lys 
                965                 970                 975     


Glu Ile Lys Asp Lys Ile Ala Ser Asp Ile Ser Asp Leu Leu Gly Ile 
            980                 985                 990         


Leu Lys Lys Glu Ile Thr Arg Asp  Ile Lys Asp Lys Leu  Thr Glu Lys 
        995                 1000                 1005             


Phe Arg  Tyr Cys Glu Glu Lys  Leu Leu Asn Ile Ser  Phe Tyr Asn 
    1010                 1015                 1020             


His Gln  Asp Lys Lys Lys Glu  Glu Gly Ile Arg Val  Phe Leu Ile 
    1025                 1030                 1035             


Arg Asp  Lys Asn Ser Asp Asn  Phe Lys Phe Glu Ser  Ile Leu Asp 
    1040                 1045                 1050             


Asp Gly  Ser Asn Lys Ile Phe  Ile Ser Lys Asn Gly  Lys Glu Ile 
    1055                 1060                 1065             


Thr Ile  Gln Cys Cys Asp Lys  Val Leu Glu Thr Leu  Met Ile Glu 
    1070                 1075                 1080             


Lys Asn  Thr Leu Lys Ile Ser  Ser Asn Gly Lys Ile  Ile Ser Leu 
    1085                 1090                 1095             


Ile Pro  His Tyr Ser Tyr Ser  Ile Asp Val Lys Tyr  
    1100                 1105                 1110 


<210> 221
<211> 5417
<212> DNA
<213> Homo sapiens

<400> 221
ctaggcggcg gccgcggcgg cggaggcagc agcggcggcg gcagtggcgg cggcgaaggt       60

ggcggcggct cggccagtac tcccggcccc cgccatttcg gactgggagc gagcgcggcg      120

caggcactga aggcggcggc ggggccagag gctcagcggc tcccaggcct gctgaaaatg      180

actgaatata aacttgtggt agttggagct ggtggcgtag gcaagagtgc cttgacgata      240

cagctaattc agaatcattt tgtggacgaa tatgatccaa caatagagga ttcctacagg      300

aagcaagtag taattgatgg agaaacctgt ctcttggata ttctcgacac agcaggtcaa      360

gaggagtaca gtgcaatgag ggaccagtac atgaggactg gggagggctt tctttgtgta      420

tttgccataa ataatactaa atcatttgaa gatattcacc attatagaga acaaattaaa      480

agagttaagg actctgaaga tgtacctatg gtcctagtag gaaataaatg tgatttgcct      540

tctagaacag tagacacaaa acaggctcag gacttagcaa gaagttatgg aattcctttt      600

attgaaacat cagcaaagac aagacagaga gtggaggatg ctttttatac attggtgaga      660

gagatccgac aatacagatt gaaaaaaatc agcaaagaag aaaagactcc tggctgtgtg      720

aaaattaaaa aatgcattat aatgtaatct gggtgttgat gatgccttct atacattagt      780

tcgagaaatt cgaaaacata aagaaaagat gagcaaagat ggtaaaaaga agaaaaagaa      840

gtcaaagaca aagtgtgtaa ttatgtaaat acaatttgta cttttttctt aaggcatact      900

agtacaagtg gtaatttttg tacattacac taaattatta gcatttgttt tagcattacc      960

taattttttt cctgctccat gcagactgtt agcttttacc ttaaatgctt attttaaaat     1020

gacagtggaa gttttttttt cctctaagtg ccagtattcc cagagttttg gtttttgaac     1080

tagcaatgcc tgtgaaaaag aaactgaata cctaagattt ctgtcttggg gcttttggtg     1140

catgcagttg attacttctt atttttctta ccaattgtga atgttggtgt gaaacaaatt     1200

aatgaagctt ttgaatcatc cctattctgt gttttatcta gtcacataaa tggattaatt     1260

actaatttca gttgagacct tctaattggt ttttactgaa acattgaggg aacacaaatt     1320

tatgggcttc ctgatgatga ttcttctagg catcatgtcc tatagtttgt catccctgat     1380

gaatgtaaag ttacactgtt cacaaaggtt ttgtctcctt tccactgcta ttagtcatgg     1440

tcactctccc caaaatatta tattttttct ataaaaagaa aaaaatggaa aaaaattaca     1500

aggcaatgga aactattata aggccatttc cttttcacat tagataaatt actataaaga     1560

ctcctaatag cttttcctgt taaggcagac ccagtatgaa atggggatta ttatagcaac     1620

cattttgggg ctatatttac atgctactaa atttttataa taattgaaaa gattttaaca     1680

agtataaaaa attctcatag gaattaaatg tagtctccct gtgtcagact gctctttcat     1740

agtataactt taaatctttt cttcaacttg agtctttgaa gatagtttta attctgcttg     1800

tgacattaaa agattatttg ggccagttat agcttattag gtgttgaaga gaccaaggtt     1860

gcaaggccag gccctgtgtg aacctttgag ctttcataga gagtttcaca gcatggactg     1920

tgtccccacg gtcatccagt gttgtcatgc attggttagt caaaatgggg agggactagg     1980

gcagtttgga tagctcaaca agatacaatc tcactctgtg gtggtcctgc tgacaaatca     2040

agagcattgc ttttgtttct taagaaaaca aactcttttt taaaaattac ttttaaatat     2100

taactcaaaa gttgagattt tggggtggtg gtgtgccaag acattaattt tttttttaaa     2160

caatgaagtg aaaaagtttt acaatctcta ggtttggcta gttctcttaa cactggttaa     2220

attaacattg cataaacact tttcaagtct gatccatatt taataatgct ttaaaataaa     2280

aataaaaaca atccttttga taaatttaaa atgttactta ttttaaaata aatgaagtga     2340

gatggcatgg tgaggtgaaa gtatcactgg actaggaaga aggtgactta ggttctagat     2400

aggtgtcttt taggactctg attttgagga catcacttac tatccatttc ttcatgttaa     2460

aagaagtcat ctcaaactct tagttttttt tttttacaac tatgtaattt atattccatt     2520

tacataagga tacacttatt tgtcaagctc agcacaatct gtaaattttt aacctatgtt     2580

acaccatctt cagtgccagt cttgggcaaa attgtgcaag aggtgaagtt tatatttgaa     2640

tatccattct cgttttagga ctcttcttcc atattagtgt catcttgcct ccctaccttc     2700

cacatgcccc atgacttgat gcagttttaa tacttgtaat tcccctaacc ataagattta     2760

ctgctgctgt ggatatctcc atgaagtttt cccactgagt cacatcagaa atgccctaca     2820

tcttatttcc tcagggctca agagaatctg acagatacca taaagggatt tgacctaatc     2880

actaattttc aggtggtggc tgatgctttg aacatctctt tgctgcccaa tccattagcg     2940

acagtaggat ttttcaaacc tggtatgaat agacagaacc ctatccagtg gaaggagaat     3000

ttaataaaga tagtgctgaa agaattcctt aggtaatcta taactaggac tactcctggt     3060

aacagtaata cattccattg ttttagtaac cagaaatctt catgcaatga aaaatacttt     3120

aattcatgaa gcttactttt tttttttggt gtcagagtct cgctcttgtc acccaggctg     3180

gaatgcagtg gcgccatctc agctcactgc aacctccatc tcccaggttc aagcgattct     3240

cgtgcctcgg cctcctgagt agctgggatt acaggcgtgt gccactacac tcaactaatt     3300

tttgtatttt taggagagac ggggtttcac cctgttggcc aggctggtct cgaactcctg     3360

acctcaagtg attcacccac cttggcctca taaacctgtt ttgcagaact catttattca     3420

gcaaatattt attgagtgcc taccagatgc cagtcaccac acaaggcact gggtatatgg     3480

tatccccaaa caagagacat aatcccggtc cttaggtagt gctagtgtgg tctgtaatat     3540

cttactaagg cctttggtat acgacccaga gataacacga tgcgtatttt agttttgcaa     3600

agaaggggtt tggtctctgt gccagctcta taattgtttt gctacgattc cactgaaact     3660

cttcgatcaa gctactttat gtaaatcact tcattgtttt aaaggaataa acttgattat     3720

attgtttttt tatttggcat aactgtgatt cttttaggac aattactgta cacattaagg     3780

tgtatgtcag atattcatat tgacccaaat gtgtaatatt ccagttttct ctgcataagt     3840

aattaaaata tacttaaaaa ttaatagttt tatctgggta caaataaaca ggtgcctgaa     3900

ctagttcaca gacaaggaaa cttctatgta aaaatcacta tgatttctga attgctatgt     3960

gaaactacag atctttggaa cactgtttag gtagggtgtt aagacttaca cagtacctcg     4020

tttctacaca gagaaagaaa tggccatact tcaggaactg cagtgcttat gaggggatat     4080

ttaggcctct tgaatttttg atgtagatgg gcattttttt aaggtagtgg ttaattacct     4140

ttatgtgaac tttgaatggt ttaacaaaag atttgttttt gtagagattt taaaggggga     4200

gaattctaga aataaatgtt acctaattat tacagcctta aagacaaaaa tccttgttga     4260

agttttttta aaaaaagcta aattacatag acttaggcat taacatgttt gtggaagaat     4320

atagcagacg tatattgtat catttgagtg aatgttccca agtaggcatt ctaggctcta     4380

tttaactgag tcacactgca taggaattta gaacctaact tttataggtt atcaaaactg     4440

ttgtcaccat tgcacaattt tgtcctaata tatacataga aactttgtgg ggcatgttaa     4500

gttacagttt gcacaagttc atctcatttg tattccattg attttttttt tcttctaaac     4560

attttttctt caaacagtat ataacttttt ttaggggatt tttttttaga cagcaaaaac     4620

tatctgaaga tttccatttg tcaaaaagta atgatttctt gataattgtg tagtaatgtt     4680

ttttagaacc cagcagttac cttaaagctg aatttatatt tagtaacttc tgtgttaata     4740

ctggatagca tgaattctgc attgagaaac tgaatagctg tcataaaatg aaactttctt     4800

tctaaagaaa gatactcaca tgagttcttg aagaatagtc ataactagat taagatctgt     4860

gttttagttt aatagtttga agtgcctgtt tgggataatg ataggtaatt tagatgaatt     4920

taggggaaaa aaaagttatc tgcagatatg ttgagggccc atctctcccc ccacaccccc     4980

acagagctaa ctgggttaca gtgttttatc cgaaagtttc caattccact gtcttgtgtt     5040

ttcatgttga aaatactttt gcatttttcc tttgagtgcc aatttcttac tagtactatt     5100

tcttaatgta acatgtttac ctggaatgta ttttaactat ttttgtatag tgtaaactga     5160

aacatgcaca ttttgtacat tgtgctttct tttgtgggac atatgcagtg tgatccagtt     5220

gttttccatc atttggttgc gctgacctag gaatgttggt catatcaaac attaaaaatg     5280

accactcttt taattgaaat taacttttaa atgtttatag gagtatgtgc tgtgaagtga     5340

tctaaaattt gtaatatttt tgtcatgaac tgtactactc ctaattattg taatgtaata     5400

aaaatagtta cagtgac                                                    5417


<210> 222
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 222
cctacgccat cagctcc                                                      17


<210> 223
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 223
gagctgttgg cgtaggc                                                      17


<210> 224
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 224
cuuucaagac uaauagauug cuccuuacga ggagac                                 36


<210> 225
<211> 3
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<400> 225
ttn                                                                      3


<210> 226
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 226
ugguaguugg agcugau                                                      17


<210> 227
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 227
gagcugaugg cguaggc                                                      17


<210> 228
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 228
ccuacgccau cagcucc                                                      17


<210> 229
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 229
tggtagttgg agctgtt                                                      17


<210> 230
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 230
gagctgttgg cgtaggc                                                      17


<210> 231
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 231
cctacgccaa cagctcc                                                      17


<210> 232
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 232
tggtagttgg agcttgt                                                      17


<210> 233
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 233
gagcttgtgg cgtaggc                                                      17


<210> 234
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 234
cctacgccac aagctcc                                                      17


<210> 235
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 235
auugcuccuu acgaggagac ccuacgccac cagcucc                                37


<210> 236
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 236
auugcuccuu acgaggagac ccuacgccau cagcucc                                37


<210> 237
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 237
guaguuggag cugguggcgu                                                   20


<210> 238
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 238
guaguuggag cugauggcgu                                                   20


<210> 239
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 239
uuggagcugg uggcguaggc                                                   20


<210> 240
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 240
uuggagcuga uggcguaggc                                                   20


<210> 241
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 241
guaguuggag cugguggcgu                                                   20


<210> 242
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 242
guaguuggag cugauggcgu agg                                               23


<210> 243
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 243
tggtagttgg agctgat                                                      17


<210> 244
<211> 478
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 244
Met Lys Asp Tyr Ile Arg Lys Thr Leu Ser Leu Arg Ile Leu Arg Pro 
1               5                   10                  15      


Tyr Tyr Gly Glu Glu Ile Glu Lys Glu Ile Ala Ala Ala Lys Lys Lys 
            20                  25                  30          


Ser Gln Ala Glu Gly Gly Asp Gly Ala Leu Asp Asn Lys Phe Trp Asp 
        35                  40                  45              


Arg Leu Lys Ala Glu His Pro Glu Ile Ile Ser Ser Arg Glu Phe Tyr 
    50                  55                  60                  


Asp Leu Leu Asp Ala Ile Gln Arg Glu Thr Thr Leu Tyr Tyr Asn Arg 
65                  70                  75                  80  


Ala Ile Ser Lys Leu Tyr His Ser Leu Ile Val Glu Arg Glu Gln Val 
                85                  90                  95      


Ser Thr Ala Lys Ala Leu Ser Ala Gly Pro Tyr His Glu Phe Arg Glu 
            100                 105                 110         


Lys Phe Asn Ala Tyr Ile Ser Leu Gly Leu Arg Glu Lys Ile Gln Ser 
        115                 120                 125             


Asn Phe Arg Arg Lys Glu Leu Ala Arg Tyr Gln Val Ala Leu Pro Thr 
    130                 135                 140                 


Ala Lys Ser Asp Thr Phe Pro Ile Pro Ile Tyr Lys Gly Phe Asp Lys 
145                 150                 155                 160 


Asn Gly Lys Gly Gly Phe Lys Val Arg Glu Ile Glu Asn Gly Asp Phe 
                165                 170                 175     


Val Ile Asp Leu Pro Leu Met Ala Tyr His Arg Val Gly Gly Lys Ala 
            180                 185                 190         


Gly Arg Glu Tyr Ile Glu Leu Asp Arg Pro Pro Ala Val Leu Asn Val 
        195                 200                 205             


Pro Val Ile Leu Ser Thr Ser Arg Arg Arg Ala Asn Lys Thr Trp Phe 
    210                 215                 220                 


Arg Asp Glu Gly Thr Asp Ala Glu Ile Arg Arg Val Met Ala Gly Glu 
225                 230                 235                 240 


Tyr Lys Val Ser Trp Val Glu Ile Leu Gln Arg Lys Arg Phe Gly Lys 
                245                 250                 255     


Pro Tyr Gly Gly Trp Tyr Val Asn Phe Thr Ile Lys Tyr Gln Pro Arg 
            260                 265                 270         


Asp Tyr Gly Leu Asp Pro Lys Val Lys Gly Gly Ile Asp Ile Gly Leu 
        275                 280                 285             


Ser Ser Pro Leu Val Cys Ala Val Thr Asn Ser Leu Ala Arg Leu Thr 
    290                 295                 300                 


Ile Arg Asp Asn Asp Leu Val Ala Phe Asn Arg Lys Ala Met Ala Arg 
305                 310                 315                 320 


Arg Arg Thr Leu Leu Arg Gln Asn Arg Tyr Lys Arg Ser Gly His Gly 
                325                 330                 335     


Ser Ala Asn Lys Leu Lys Pro Ile Glu Ala Leu Thr Glu Lys Asn Glu 
            340                 345                 350         


Leu Tyr Arg Lys Ala Ile Met Arg Arg Trp Ala Arg Glu Ala Ala Asp 
        355                 360                 365             


Phe Phe Arg Gln His Arg Ala Ala Thr Val Asn Met Glu Asp Leu Thr 
    370                 375                 380                 


Gly Ile Lys Asp Arg Glu Asp Tyr Phe Ser Gln Met Leu Arg Cys Tyr 
385                 390                 395                 400 


Trp Asn Tyr Ser Gln Leu Gln Thr Met Leu Glu Asn Lys Leu Lys Glu 
                405                 410                 415     


Tyr Gly Ile Ala Val Lys Tyr Ile Glu Pro Lys Asp Thr Ser Lys Thr 
            420                 425                 430         


Cys His Ser Cys Gly His Val Asn Glu Tyr Phe Asp Phe Asn Tyr Arg 
        435                 440                 445             


Ser Ala His Lys Phe Pro Met Phe Lys Cys Glu Lys Cys Gly Val Glu 
    450                 455                 460                 


Cys Gly Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Gln Ala 
465                 470                 475             


<210> 245
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 245
gttggagctg atggcgtagg c                                                 21


<210> 246
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 246
gagctgatgg cgtaggc                                                      17


<210> 247
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 247
gttggagctg ttggcgtagg c                                                 21


<210> 248
<211> 822
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 248
Met Val Lys Asn Pro Ala Asn Arg His Ala Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Ser Glu Val Asp Asn Asn Asn Ile Leu Glu Phe Lys Ile Lys Tyr Glu 
            20                  25                  30          


Lys Leu Ala Arg Leu Asp Lys Val Glu Val Lys Ser Met His Phe Asp 
        35                  40                  45              


Asn Asn Lys Gln Val Val Phe Asp Glu Val Val Ile Asn Gly Gly Leu 
    50                  55                  60                  


Ile Glu Pro Thr Tyr Glu Asp Lys His Lys Lys Leu Val Val Thr Ala 
65                  70                  75                  80  


Gly Glu Lys Ser Tyr Ser Ile Val Gly Gln Lys Val Gly Gly Lys Pro 
                85                  90                  95      


Arg Leu Leu Glu Asp Arg Val Ser Lys Thr Lys Val Gln Leu Glu Leu 
            100                 105                 110         


Thr Asn Tyr Val Glu Asp Lys Glu Gly Lys Lys Arg Val Ser Lys Thr 
        115                 120                 125             


Glu Arg Glu Leu Ile Val Ala Asp Asn Ile Glu Leu Tyr Ser Gln Ile 
    130                 135                 140                 


Val Gly Arg Glu Val Lys Thr Thr Lys Glu Ile Tyr Leu Ile Lys Arg 
145                 150                 155                 160 


Phe Leu Glu Tyr Arg Ser Asp Leu Leu Phe Tyr Tyr Gly Phe Val Asp 
                165                 170                 175     


Asn Phe Phe Lys Val Ala Gly Asn Gly Lys Glu Leu Trp Lys Ile Asp 
            180                 185                 190         


Phe Thr Asn Ser Asp Ser Leu His Leu Ile Glu Tyr Phe Lys Phe Ser 
        195                 200                 205             


Ile Asn Asp Asn Leu Lys Asn Asp Glu Asn Tyr Leu Lys Asn Tyr Val 
    210                 215                 220                 


Ser Asp Asn Thr Lys Ile Glu Asn Asp Leu Val Lys Cys Gln Asn Asn 
225                 230                 235                 240 


Phe Asn Ser Leu Arg His Ala Leu Met His Phe Asp Tyr Asp Phe Phe 
                245                 250                 255     


Glu Lys Leu Phe Asn Gly Glu Asp Val Gly Phe Asp Phe Asp Ile Glu 
            260                 265                 270         


Phe Leu Asn Ile Met Ile Asp Lys Val Asp Lys Leu Asn Ile Asp Thr 
        275                 280                 285             


Lys Lys Glu Phe Ile Asp Asp Glu Glu Val Thr Leu Phe Gly Glu Ala 
    290                 295                 300                 


Leu Ser Leu Lys Lys Leu Tyr Gly Leu Phe Ser His Ile Ala Ile Asn 
305                 310                 315                 320 


Arg Val Ala Phe Asn Lys Leu Ile Asn Ser Phe Ile Ile Glu Asp Gly 
                325                 330                 335     


Ile Glu Asn Lys Glu Leu Lys Asp Phe Phe Asn Asn Lys Lys Glu Ser 
            340                 345                 350         


Gln Ala Tyr Glu Ile Asp Ile His Ser Asn Ala Glu Tyr Lys Ala Leu 
        355                 360                 365             


Tyr Val Gln His Lys Lys Leu Val Met Ala Thr Ser Ala Met Thr Asp 
    370                 375                 380                 


Gly Asp Glu Ile Ala Lys Lys Asn Gln Glu Ile Ser Asp Leu Lys Glu 
385                 390                 395                 400 


Lys Met Lys Val Ile Thr Lys Glu Asn Ser Leu Ala Arg Leu Glu His 
                405                 410                 415     


Lys Leu Arg Leu Ala Phe Gly Phe Ile Tyr Thr Glu Tyr Lys Asp Tyr 
            420                 425                 430         


Lys Thr Phe Lys Lys His Phe Asp Gln Asp Ile Lys Gly Ala Lys Tyr 
        435                 440                 445             


Lys Gly Leu Asn Val Glu Lys Leu Lys Glu Tyr Tyr Glu Thr Thr Leu 
    450                 455                 460                 


Lys Asn Ser Lys Pro Lys Thr Asp Glu Lys Leu Glu Asp Val Ala Lys 
465                 470                 475                 480 


Lys Ile Asp Lys Leu Ser Leu Lys Glu Leu Ile Asp Asp Asp Thr Leu 
                485                 490                 495     


Leu Lys Phe Val Leu Leu Leu Phe Ile Phe Met Pro Gln Glu Leu Lys 
            500                 505                 510         


Gly Asp Phe Leu Gly Phe Ile Lys Lys Tyr Tyr His Asp Lys Lys His 
        515                 520                 525             


Ile Asp Gln Asp Thr Lys Asp Lys Asp Thr Glu Ile Glu Glu Leu Ser 
    530                 535                 540                 


Thr Gly Leu Lys Leu Lys Val Leu Asp Lys Asn Ile Arg Ser Leu Ser 
545                 550                 555                 560 


Ile Leu Lys His Ser Phe Ser Phe Gln Val Lys Tyr Asn Arg Lys Asp 
                565                 570                 575     


Lys Asn Phe Tyr Glu Asp Gly Asn Leu His Gly Lys Phe Tyr Lys Lys 
            580                 585                 590         


Leu Ser Ile Ser His Asn Gln Glu Glu Phe Asn Lys Ser Val Tyr Ala 
        595                 600                 605             


Pro Leu Phe Arg Tyr Tyr Ser Ala Leu Tyr Lys Leu Ile Asn Asp Phe 
    610                 615                 620                 


Glu Ile Tyr Ala Leu Ala Gln His Val Glu Asn His Glu Thr Leu Ala 
625                 630                 635                 640 


Asp Gln Val Asn Lys Ser Gln Phe Ile Gln Lys Ser Tyr Phe Asn Phe 
                645                 650                 655     


Arg Lys Leu Leu Asp Asn Thr Asp Ser Ile Ser Gln Ser Ser Ser Tyr 
            660                 665                 670         


Asn Thr Leu Ile Val Met Arg Asn Asp Ile Ser His Leu Ser Tyr Glu 
        675                 680                 685             


Pro Leu Phe Asn Tyr Pro Leu Asp Glu Arg Lys Ser Tyr Lys Lys Lys 
    690                 695                 700                 


Thr Gln Lys Gly Val Lys Thr Phe His Val Glu Leu Leu Tyr Ile Ser 
705                 710                 715                 720 


Arg Ala Lys Ile Ile Glu Leu Ile Ser Leu Gln Thr Asp Met Lys Lys 
                725                 730                 735     


Leu Leu Gly Tyr Asp Ala Val Asn Asp Phe Asn Met Lys Val Val His 
            740                 745                 750         


Leu Arg Lys Arg Leu Ser Val Tyr Ala Asn Lys Glu Glu Ser Ile Arg 
        755                 760                 765             


Lys Met Gln Ala Asp Ala Lys Thr Pro Asn Asp Phe Tyr Asn Ile Tyr 
    770                 775                 780                 


Lys Val Lys Gly Val Glu Ser Ile Asn Gln His Leu Leu Lys Val Ile 
785                 790                 795                 800 


Gly Val Thr Glu Ala Glu Lys Ser Ile Glu Lys Gln Ile Asn Glu Gly 
                805                 810                 815     


Asn Lys Lys His Asn Thr 
            820         


<210> 249
<211> 845
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 249
Met Ile Lys Lys Pro Ser Asn Arg His Ala Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Ser Lys Val Asp Asn Gln Asn Ile Leu Glu Phe Lys Ile Lys Tyr Lys 
            20                  25                  30          


Lys Leu Ser Arg Leu Asp Arg Val Glu Ile Lys Thr Met His Tyr Asp 
        35                  40                  45              


Asp Arg Ala Ile Val Phe Asp Glu Val Ile Ile Asn Gly Gly Leu Ile 
    50                  55                  60                  


Asp Val Glu Tyr Arg Asp Asn His Lys Thr Ile Phe Val Lys Val Gly 
65                  70                  75                  80  


Asp Lys Ser Tyr Ser Ile Ser Gly Gln Lys Val Gly Gly Lys Glu Arg 
                85                  90                  95      


Leu Leu Glu Asn Arg Ile Ser Gln Thr Lys Val Gln Leu Glu Leu Lys 
            100                 105                 110         


Asp Glu Ala Thr Asn Arg Val Ser Lys Thr Glu Arg Glu Leu Ile Val 
        115                 120                 125             


Asp Asp Asn Ile Lys Leu Tyr Ser Gln Ile Val Gly Arg Asp Val Lys 
    130                 135                 140                 


Thr Thr Lys Asp Ile Tyr Leu Ile Lys Arg Phe Leu Gly Tyr Arg Ser 
145                 150                 155                 160 


Asp Leu Leu Phe Tyr Tyr Gly Phe Val Asn Asn Phe Phe His Val Ala 
                165                 170                 175     


Asn Asn Arg Pro Glu Phe Trp Lys Ile Asp Phe Asn Asp Asn Arg Asn 
            180                 185                 190         


Ser Lys Leu Ile Glu Tyr Phe Ile Phe Thr Ile Asn Asp His Leu Lys 
        195                 200                 205             


Asn Asp Glu Asn Tyr Leu Lys Asp Tyr Ile Ser Asp Arg Gly Gln Ile 
    210                 215                 220                 


Val Asp Asp Leu Glu Asn Ile Lys His Ile Phe Ser Ala Leu Arg His 
225                 230                 235                 240 


Gly Leu Met His Phe Asp Tyr Asp Phe Phe Glu Ala Leu Phe Asn Gly 
                245                 250                 255     


Glu Asp Ile Asp Ile Lys Met Asp Asn Gln Gly Asn Thr Gln Pro Leu 
            260                 265                 270         


Ser Ser Leu Asn Ile Lys Phe Leu Asp Ile Met Ile Asp Lys Leu Asp 
        275                 280                 285             


Lys Leu Asn Ile Asp Thr Lys Lys Glu Phe Ile Asp Ala Glu Lys Ile 
    290                 295                 300                 


Thr Ile Phe Gly Glu Glu Leu Ser Leu Ala Lys Leu Tyr Arg Phe Tyr 
305                 310                 315                 320 


Ala His Thr Ala Ile Asn Arg Val Ala Phe Asn Lys Leu Ile Asn Ser 
                325                 330                 335     


Phe Ile Ile Glu Asn Gly Val Glu Asn Gln Ser Leu Lys Glu Tyr Phe 
            340                 345                 350         


Asn Gln Gln Ala Gly Gly Ile Ala Tyr Glu Ile Asp Ile His Gln Asn 
        355                 360                 365             


Arg Glu Tyr Lys Asn Leu Tyr Asn Glu His Lys Lys Leu Val Ser Arg 
    370                 375                 380                 


Val Leu Ser Ile Ser Asp Gly Gln Glu Ile Ala Thr Leu Asn Gln Lys 
385                 390                 395                 400 


Ile Val Glu Leu Lys Glu Gln Met Lys Gln Ile Thr Lys Ile Asn Ser 
                405                 410                 415     


Ile Lys Arg Leu Glu Tyr Lys Leu Arg Leu Ala Phe Gly Phe Ile Tyr 
            420                 425                 430         


Thr Glu Tyr Lys Asn Tyr Glu Glu Phe Lys Asn Ser Phe Asp Thr Asp 
        435                 440                 445             


Ile Lys Asn Gly Arg Phe Thr Pro Lys Asp Glu Asp Gly Asn Lys Arg 
    450                 455                 460                 


Ala Phe Asp Ser Arg Glu Leu Glu His Leu Lys Gly Tyr Tyr Lys Ala 
465                 470                 475                 480 


Thr Leu Gln Thr Gln Lys Pro Gln Thr Asp Glu Lys Met Glu Glu Val 
                485                 490                 495     


Ser Lys Arg Val Asp Arg Leu Ser Leu Lys Ser Leu Ile Gly Asp Asp 
            500                 505                 510         


Thr Leu Leu Lys Phe Ile Leu Leu Met Phe Thr Phe Met Pro Gln Glu 
        515                 520                 525             


Leu Lys Gly Glu Phe Leu Gly Phe Ile Lys Lys Tyr Tyr His Asp Thr 
    530                 535                 540                 


Lys His Ile Asp Gln Asp Thr Ile Ser Asp Ser Asp Asp Thr Ile Glu 
545                 550                 555                 560 


Glu Gly Leu Ser Ile Gly Leu Lys Leu Lys Ile Leu Asp Lys Asn Ile 
                565                 570                 575     


Arg Ser Leu Ser Ile Leu Lys His Ser Leu Ser Phe Gln Thr Lys Tyr 
            580                 585                 590         


Asn Lys Lys Asp Arg Ser Tyr Tyr Glu Asp Gly Asn Ile His Gly Lys 
        595                 600                 605             


Phe Phe Lys Lys Leu Gly Ile Ser His Asn Gln Glu Glu Phe Asn Lys 
    610                 615                 620                 


Ser Val Tyr Ala Pro Leu Phe Arg Tyr Tyr Ser Ala Leu Tyr Lys Leu 
625                 630                 635                 640 


Ile Asn Asp Phe Glu Ile Tyr Thr Leu Ser Leu His Ile Val Gly Asn 
                645                 650                 655     


Glu Thr Leu Ser Asp Gln Val Asn Lys Pro Gln Phe Leu Ser Gly Arg 
            660                 665                 670         


Tyr Phe Asn Phe Arg Lys Leu Leu Thr Gln Ser Tyr Asn Ile Ser Asn 
        675                 680                 685             


Asn Ser Thr His Ser Val Ile Phe Asn Ala Val Ile Asn Met Arg Asn 
    690                 695                 700                 


Asp Ile Ser His Leu Ser Tyr Glu Pro Leu Leu Asp Cys Pro Leu Asn 
705                 710                 715                 720 


Gly Lys Lys Ser Tyr Lys Arg Lys Ile Arg Asn Gln Phe Arg Thr Ile 
                725                 730                 735     


Asn Ile Lys Pro Leu Val Glu Ser Arg Lys Met Ile Ile Asp Phe Ile 
            740                 745                 750         


Thr Leu Gln Thr Asp Met Gln Lys Val Leu Gly Cys Asp Ala Val Asn 
        755                 760                 765             


Asp Phe Thr Met Lys Ile Val Gln Leu Arg Thr Arg Leu Lys Ala Tyr 
    770                 775                 780                 


Ala Asn Lys Glu Gln Thr Ile Glu Lys Met Ile Thr Glu Ala Lys Thr 
785                 790                 795                 800 


Pro Asn Asp Phe Tyr Asn Ile Tyr Lys Val Lys Gly Val Glu Ala Ile 
                805                 810                 815     


Asn Lys Tyr Leu Leu Glu Val Ile Gly Glu Thr Gln Val Glu Lys Glu 
            820                 825                 830         


Ile Arg Glu Glu Ile Glu Arg Gly Asn Ile Ala Asn Ser 
        835                 840                 845 


<210> 250
<211> 809
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 250
Met Ile Lys Asn Pro Ser Asn Arg His Ser Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Ser Glu Val Asp His Glu Lys Ile Leu Glu Phe Lys Ile Lys Tyr Glu 
            20                  25                  30          


Lys Leu Ala Arg Leu Asp Arg Phe Glu Val Lys Ala Met His Tyr Glu 
        35                  40                  45              


Gly Lys Glu Ile Val Phe Asp Glu Val Leu Val Asn Gly Gly Leu Ile 
    50                  55                  60                  


Glu Val Glu Tyr Gln Asp Asp Asn Lys Thr Leu Phe Val Lys Val Gly 
65                  70                  75                  80  


Glu Lys Ser Tyr Ser Ile Arg Gly Lys Lys Val Gly Gly Lys Gln Arg 
                85                  90                  95      


Leu Leu Glu Asp Arg Val Ser Lys Thr Lys Val Gln Leu Glu Leu Ser 
            100                 105                 110         


Asp Gly Val Val Asp Asn Lys Gly Asn Leu Arg Lys Ser Arg Thr Glu 
        115                 120                 125             


Arg Glu Leu Ile Val Ala Asp Asn Ile Lys Leu Tyr Ser Gln Ile Val 
    130                 135                 140                 


Gly Arg Glu Val Thr Thr Thr Lys Glu Ile Tyr Leu Val Lys Arg Phe 
145                 150                 155                 160 


Leu Ala Tyr Arg Ser Asp Leu Leu Phe Tyr Tyr Ser Phe Val Asp Asn 
                165                 170                 175     


Phe Phe Lys Val Ala Gly Asn Glu Lys Glu Leu Trp Lys Ile Asn Phe 
            180                 185                 190         


Asp Asp Ala Thr Ser Ala Gln Phe Met Gly Tyr Ile Pro Phe Met Val 
        195                 200                 205             


Asn Asp Asn Leu Lys Asn Asp Asn Ala Tyr Leu Lys Asp Tyr Val Arg 
    210                 215                 220                 


Asn Asp Val Gln Ile Lys Asp Asp Leu Lys Lys Val Gln Thr Ile Phe 
225                 230                 235                 240 


Ser Ala Leu Arg His Thr Leu Leu His Phe Asn Tyr Glu Phe Phe Glu 
                245                 250                 255     


Lys Leu Phe Asn Gly Glu Asp Val Gly Phe Asp Phe Asp Ile Gly Phe 
            260                 265                 270         


Leu Asn Leu Leu Ile Glu Asn Ile Asp Lys Leu Asn Ile Asp Ala Lys 
        275                 280                 285             


Lys Glu Phe Ile Asp Asn Glu Lys Ile Arg Leu Phe Gly Glu Asn Leu 
    290                 295                 300                 


Ser Leu Ala Lys Val Tyr Arg Leu Tyr Ser Asp Ile Cys Val Asn Arg 
305                 310                 315                 320 


Val Gly Phe Asn Lys Phe Ile Asn Ser Met Leu Ile Lys Asp Gly Val 
                325                 330                 335     


Glu Asn Gln Val Leu Lys Ala Glu Phe Asn Arg Lys Phe Gly Gly Asn 
            340                 345                 350         


Ala Tyr Thr Ile Asp Ile His Ser Asn Gln Glu Tyr Lys Arg Ile Tyr 
        355                 360                 365             


Asn Glu His Lys Lys Leu Val Ile Lys Val Ser Thr Leu Lys Asp Gly 
    370                 375                 380                 


Gln Ala Ile Arg Arg Gly Asn Lys Lys Ile Ser Glu Leu Lys Glu Gln 
385                 390                 395                 400 


Met Lys Ser Met Thr Lys Lys Asn Ser Leu Ala Arg Leu Glu Cys Lys 
                405                 410                 415     


Met Arg Leu Ala Phe Gly Phe Leu Tyr Gly Glu Tyr Asn Asn Tyr Lys 
            420                 425                 430         


Ala Phe Lys Asn Asn Phe Asp Thr Asn Ile Lys Asn Ser Gln Phe Asp 
        435                 440                 445             


Val Asn Asp Val Glu Lys Ser Lys Ala Tyr Phe Leu Ser Thr Tyr Glu 
    450                 455                 460                 


Arg Arg Lys Pro Arg Thr Arg Glu Lys Leu Glu Lys Val Ala Lys Asp 
465                 470                 475                 480 


Ile Glu Ser Leu Glu Leu Lys Thr Val Ile Ala Asn Asp Thr Leu Leu 
                485                 490                 495     


Lys Phe Ile Leu Leu Met Phe Val Phe Met Pro Gln Glu Leu Lys Gly 
            500                 505                 510         


Asp Phe Leu Gly Phe Val Lys Lys Tyr Tyr His Asp Val His Ser Ile 
        515                 520                 525             


Asp Asp Asp Thr Lys Glu Gln Glu Glu Asp Val Val Glu Ala Met Ser 
    530                 535                 540                 


Thr Ser Leu Lys Leu Lys Ile Leu Gly Arg Asn Ile Arg Ser Leu Thr 
545                 550                 555                 560 


Leu Phe Lys Tyr Ala Leu Ser Ser Gln Val Asn Tyr Asn Ser Thr Asp 
                565                 570                 575     


Asn Ile Phe Tyr Val Glu Gly Asn Arg Tyr Gly Lys Ile Tyr Lys Lys 
            580                 585                 590         


Leu Gly Ile Ser His Asn Gln Glu Glu Phe Asp Lys Thr Leu Val Val 
        595                 600                 605             


Pro Leu Leu Arg Tyr Tyr Ser Ser Leu Phe Lys Leu Met Asn Asp Phe 
    610                 615                 620                 


Glu Ile Tyr Ser Leu Ala Lys Ala Asn Pro Thr Ala Val Ser Leu Gln 
625                 630                 635                 640 


Glu Leu Val Asp Asp Glu Thr Ser Pro Tyr Lys Gln Gly Asn Tyr Phe 
                645                 650                 655     


Asn Phe Asn Lys Met Leu Arg Asp Ile Tyr Gly Leu Thr Ser Asp Glu 
            660                 665                 670         


Ile Lys Ser Gly Gln Val Val Phe Met Arg Asn Lys Ile Ala His Phe 
        675                 680                 685             


Asp Thr Glu Val Leu Leu Ser Lys Pro Leu Leu Gly Gln Thr Lys Met 
    690                 695                 700                 


Asn Leu Gln Arg Lys Asp Ile Val Ser Phe Ile Glu Ala Arg Gly Asp 
705                 710                 715                 720 


Ile Lys Glu Leu Leu Gly Tyr Asp Ala Ile Asn Asp Phe Arg Met Lys 
                725                 730                 735     


Val Ile His Leu Arg Thr Lys Met Arg Val Tyr Ser Asp Lys Leu Gln 
            740                 745                 750         


Thr Met Met Asp Leu Leu Arg Asn Ala Lys Thr Pro Asn Asp Phe Tyr 
        755                 760                 765             


Asn Val Tyr Lys Val Lys Gly Val Glu Ser Ile Asn Lys His Leu Leu 
    770                 775                 780                 


Glu Val Leu Ala Gln Thr Ala Glu Glu Arg Thr Val Glu Lys Gln Ile 
785                 790                 795                 800 


Arg Asp Gly Asn Glu Lys Tyr Asp Leu 
                805                 


<210> 251
<211> 1238
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 251
Met Asn Gln Tyr Ile His Ala Asn Lys Lys Glu Asn Lys Lys Arg Pro 
1               5                   10                  15      


Asn Lys Ser Ser Ile Ile Arg Ile Met Val Ser Asp Phe Asp Asp Glu 
            20                  25                  30          


Tyr Ile Gln Glu Ile Lys Val Leu Tyr Ile Lys Gln Gly Gly Val Asp 
        35                  40                  45              


Thr Phe Lys Ile Asn Lys Met Ser Tyr Asp Ser Ala Ser Lys Lys Ile 
    50                  55                  60                  


Ile Phe Glu Glu Val Ala Thr Gln Asn Met Leu Ser Val Glu Asp Ser 
65                  70                  75                  80  


Asn Leu Asn Phe Lys Arg Pro Met Val Glu Cys Lys Asn Gly Asp Ile 
                85                  90                  95      


Tyr Val Val Lys Pro Ser Glu Lys Val Asn Glu Lys Gly Gln Ala Ile 
            100                 105                 110         


Glu Pro Leu Arg Ser Tyr Lys Ile His Gly Lys Tyr Leu Asp Leu Thr 
        115                 120                 125             


Glu Glu Ile Gly Lys Asp Asn Ala Glu Gln Ser Gly Lys Lys Gln Ile 
    130                 135                 140                 


Tyr Leu His Val Glu Asp Leu Leu Gly Met His Thr Thr Ala Asp Ser 
145                 150                 155                 160 


Ile Asp Arg Arg Arg Leu Glu Ser Glu Thr Gln Arg Thr Leu Leu Ser 
                165                 170                 175     


Lys Glu Val Met Glu Asn Tyr Ala Leu Ile Met Gly His Glu Ile Lys 
            180                 185                 190         


Leu Asp Glu Ser Asp Glu Thr Tyr Lys Leu Ala Ser Ser Lys Glu Ile 
        195                 200                 205             


Tyr Lys Ala Asn Arg Phe Leu Asp Tyr Arg Ser Arg Leu Leu Tyr Tyr 
    210                 215                 220                 


Tyr Ser Phe Ile Asn His Phe Leu Val Gly Leu Ser Lys Gly Ala Thr 
225                 230                 235                 240 


Tyr Glu Tyr Ala Gly Lys Ser Leu Val Ala Lys Ile Pro Asp Gly Glu 
                245                 250                 255     


Val Trp Gln Leu Cys Glu Leu Glu Val Thr Ala Tyr His Gly Ile Tyr 
            260                 265                 270         


Ile Asn Lys Lys Arg Asn Glu Leu Val Asn Glu Asn Ser Leu Lys Ile 
        275                 280                 285             


Asp Ala Ile Tyr Ala Gln Met Ala Lys Asn Met Lys Glu Thr Ile Asn 
    290                 295                 300                 


Glu Phe Val Asp Asn Tyr Asn Ala Met Ile Glu Lys Gln Asn Glu Leu 
305                 310                 315                 320 


Lys Asp Asn Lys Ser Tyr Lys Ile Asn Lys Lys Ala Gln Asn Thr Thr 
                325                 330                 335     


Lys Phe Glu Asn Phe Thr Glu Glu Lys Ile Asn Gln Asp Leu His Asn 
            340                 345                 350         


Ile Val Tyr Ile Leu Ser Asp Leu Arg His Lys Leu Met His Phe Glu 
        355                 360                 365             


Tyr His Tyr Phe Glu Leu Leu Met Thr Gly Lys Lys Met Gly Glu Lys 
    370                 375                 380                 


Ser Glu Val Ile Val Cys Val Pro Asp Arg Asn Ser Glu Leu Pro Ala 
385                 390                 395                 400 


Ser Lys Asn Glu Pro Ser Lys Asp Lys Phe Arg Lys Glu Lys Lys Leu 
                405                 410                 415     


Ser Glu Leu Leu Asp Leu Asn Ile Leu Lys Glu Leu Asp Thr Phe Val 
            420                 425                 430         


Lys Val Lys Glu Ser Tyr Gln Thr Thr Tyr Leu Glu Thr Asn Asp Lys 
        435                 440                 445             


Ile Glu Ile Leu Gly Lys Leu Lys Thr Ala Lys Ser Ile Tyr Gln Ile 
    450                 455                 460                 


Tyr His Gln Ile Cys Gln Arg Lys Asn Gly Phe Asn Lys Phe Ile Asn 
465                 470                 475                 480 


Ser Phe Phe Thr Val Asp Gly Glu Glu Asn Thr Glu Val Lys Asp Cys 
                485                 490                 495     


Ile Asn Glu Val Phe Arg Lys Glu Ile His Tyr Phe Glu Met Val Ile 
            500                 505                 510         


Ala Lys Ser Asn Glu Asp Thr Leu Asn Asp Lys Asn Lys Asn Lys Ser 
        515                 520                 525             


Lys Lys Thr Arg Asp Arg Met Lys Asn Gln Ile Gln Glu Cys Lys Arg 
    530                 535                 540                 


Tyr Gln Asp Asp Glu Ser Asn Ile Asp Thr Trp Val Ala Tyr His Lys 
545                 550                 555                 560 


Asp Ile His Tyr Ser Lys Arg Tyr Lys Lys Leu Tyr Cys Glu His Ile 
                565                 570                 575     


Thr Leu Val Asp Asn Leu Asn Ser Ala Val Ser Asn Gly Leu Asn Gly 
            580                 585                 590         


Gln Val Ile Lys Glu Ile Asn Asp Asp Ile Ala Ile Lys Lys Arg Glu 
        595                 600                 605             


Met Asn Glu Ile Thr Lys Ala Asn Ser Lys Ser Arg Leu Arg Tyr Lys 
    610                 615                 620                 


Met Gln Met Ala Tyr Gly Phe Leu Phe Val Glu Tyr Gly Leu Lys Ile 
625                 630                 635                 640 


Pro Lys Phe Leu Asn Asp Phe Asp Leu Ser His Val Arg Thr Ala Ser 
                645                 650                 655     


Lys Ile Lys Gly Tyr Lys Ser Pro Val Lys Val Thr Gln Tyr Leu Thr 
            660                 665                 670         


Asn Asp Glu Gly Asn Lys Asp Asn Phe Asn Leu Glu Thr Leu Met Glu 
        675                 680                 685             


Asp Ile Asp Lys Lys Ser Lys Ile Asn Phe Glu Phe Leu Lys Ser Asn 
    690                 695                 700                 


Glu Asp Asn Asn Leu Ile Lys Leu Tyr Ile Leu Ile Tyr Gln Leu Leu 
705                 710                 715                 720 


Pro Arg Glu Leu Lys Gly Asp Phe Leu Gly Phe Val Lys Asn Asn Tyr 
                725                 730                 735     


Tyr Asp Leu Lys His Val Asp Phe Gln Thr Arg Glu Thr Glu Ala Lys 
            740                 745                 750         


Asp Gln Phe Phe His Asn Met Arg Leu Phe Glu Lys Asn Val Lys Ala 
        755                 760                 765             


Phe Asp Leu Ile Gln Tyr Ser Ile Gly Asp Glu Met Ser Gln Leu Gly 
    770                 775                 780                 


Asn Glu Thr Phe Asn Phe Ser Gln Ala Leu Ser Lys Ile Val Ser Asp 
785                 790                 795                 800 


Asp Thr Ile Leu Asn Ser Ala Thr Glu Ile Pro Asn Ile Asn Arg Leu 
                805                 810                 815     


Val Tyr Gly Ser Leu Leu Lys Tyr Tyr Glu Asn Ala Phe Arg Leu Ser 
            820                 825                 830         


Ser Glu Ile Glu Ile Arg Ala Leu Ile Lys Ile Ala Arg Gly Lys Gln 
        835                 840                 845             


Ile Asp Asn His Ser Ile Asp Glu Ala Tyr Lys Asp Ala Leu Ile Phe 
    850                 855                 860                 


Gln Lys Ser Gly Gln Thr Val Lys Phe Ser Ser Ile Leu Lys Tyr Phe 
865                 870                 875                 880 


Asn Ile Asp Asp Leu Asn Lys Lys Asn Asp Ser Lys Ile Tyr Asn Lys 
                885                 890                 895     


Ala Ser Asn Leu Arg Asn Lys Ile Ala His Cys Asp Tyr Thr Val Leu 
            900                 905                 910         


Phe Ile Thr Asn Ile Ile Cys Glu Ala Glu Asn Ile Asn Val Lys Ala 
        915                 920                 925             


Lys Tyr Leu Ile Asp Val Ser Asn Lys Ile Gly Leu Asn Thr Val Asp 
    930                 935                 940                 


Leu Gly Asn Asp Met Val Asn Asp Tyr Leu Met Ser Tyr Asp Lys Gln 
945                 950                 955                 960 


Met Thr Tyr Leu Ala Lys Thr Ser Glu Glu Leu Leu Lys Glu Ser Ser 
                965                 970                 975     


Leu Asp Lys Ser Lys Glu Lys Lys Glu Arg Arg Asp Asn Leu Lys Asn 
            980                 985                 990         


Glu Thr Arg Ser His Ser Glu Ile  Tyr Met Glu Tyr Glu  Trp Ile Ser 
        995                 1000                 1005             


Asp Tyr  Leu Val Lys Leu Lys  Asp Asn His Glu Ile  Leu Ser Lys 
    1010                 1015                 1020             


Lys Asn  Lys Thr Glu Asp Leu  Lys Leu Asn Arg Ala  Tyr Glu Leu 
    1025                 1030                 1035             


Ile Lys  Asn Tyr Asn Val Ala  Leu Asn Lys Lys Ser  Lys Ile Lys 
    1040                 1045                 1050             


Ile Arg  Ala Leu Thr Thr Asp  His Ile Asn Asn Asn  Trp Val Asn 
    1055                 1060                 1065             


Ile Trp  Gly Ala Leu Thr His  Glu Leu Gln Glu Ile  Lys Gly Leu 
    1070                 1075                 1080             


Tyr Leu  Tyr Lys Val Thr Pro  Lys Ile Lys Lys Gly  Ile Tyr Phe 
    1085                 1090                 1095             


Val Leu  Thr Asp Lys Lys Asn  Tyr Cys Leu Asn Ile  Asn Leu Tyr 
    1100                 1105                 1110             


Thr Leu  Lys Lys Val Pro Ser  Lys Asp Asp Ser Glu  Met Thr Glu 
    1115                 1120                 1125             


Glu Arg  Tyr Leu Arg Asp Ile  Ser Glu Lys Tyr Tyr  Phe Thr Val 
    1130                 1135                 1140             


Gly Glu  Asp Ser Ile Lys Ala  Leu Lys Glu Arg Leu  Gln Thr Ile 
    1145                 1150                 1155             


Asn Asp  Lys Cys Ile Ile Thr  Tyr Val Asn Glu Ile  Asp Cys Lys 
    1160                 1165                 1170             


Asn Glu  Asn Ile Lys Glu Lys  Pro Glu Phe Lys Ile  Ala Glu Asp 
    1175                 1180                 1185             


Tyr Asn  Ser Trp Asp Lys Lys  Tyr Leu Ser Ile Ser  Asn Glu Glu 
    1190                 1195                 1200             


Leu His  His Trp Ser Val Glu  Thr Arg Arg Asp Lys  Lys Tyr Lys 
    1205                 1210                 1215             


Glu Asn  Leu Ile Leu Asn Leu  Met Glu Lys Ser Ser  Phe Lys Leu 
    1220                 1225                 1230             


Asn Leu  His Gln Leu 
    1235             


<210> 252
<211> 849
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 252
Met Ser Gln Leu Lys Asn Pro Ser Asn Lys Asn Ser Leu Pro Arg Ile 
1               5                   10                  15      


Ile Ile Ser Asp Phe Asn Glu Ile Lys Ile Asn Glu Ile Lys Ile Lys 
            20                  25                  30          


Tyr His Lys Leu Asp Arg Leu Asp Lys Ile Ile Val Lys Glu Met Glu 
        35                  40                  45              


Ile Ile Asn Asn Lys Ile Phe Phe Lys Lys Ile Leu Phe Asn Asn Gln 
    50                  55                  60                  


Ile Lys Asp Ile Asn Ser Glu Asn Ile Glu Leu Glu Asn Tyr Ile Leu 
65                  70                  75                  80  


Ala Gly Glu Val Lys Pro Ser Asn Thr Lys Ile Ile Leu Asn Arg Asp 
                85                  90                  95      


Gly Lys Glu Lys Ser Phe Ile Val Tyr Asp Gly Phe Thr Phe Lys Tyr 
            100                 105                 110         


Lys Pro Asn Asp Lys Arg Ile Ser Glu Thr Lys Thr Asn Ala Lys Tyr 
        115                 120                 125             


Ile Leu Thr Ile Lys Asp Lys Thr Arg His Arg Glu Ser Ser Thr Gln 
    130                 135                 140                 


Arg Asp Ile Leu Lys Ser Ser Ile Ile Glu Thr Tyr Lys Gln Ile Ser 
145                 150                 155                 160 


Gly Phe Glu Asn Ile Thr Ser Lys Asp Ile Tyr Thr Ile Lys Arg Tyr 
                165                 170                 175     


Ile Asp Phe Lys Asn Glu Met Met Phe Tyr Tyr Thr Phe Ile Asp Asp 
            180                 185                 190         


Phe Phe Phe Pro Ile Thr Gly Lys Asn Lys Gln Asp Lys Lys Asn Asn 
        195                 200                 205             


Phe Tyr Asn Tyr Lys Ile Lys Glu Asn Ala Lys Lys Phe Ile Ser Leu 
    210                 215                 220                 


Ile Asn Tyr Arg Ile Asn Asp Asp Phe Lys Asn Lys Asn Gly Ile Leu 
225                 230                 235                 240 


Tyr Asp Tyr Leu Ser Asn Lys Glu Glu Ile Ile Ile Asn Asp Phe Ile 
                245                 250                 255     


His Ile Gln Thr Ile Leu Lys Asp Val Arg His Ala Ile Ala His Phe 
            260                 265                 270         


Asn Phe Asp Phe Ile Gln Lys Leu Phe Asp Asn Glu Gln Ala Phe Asn 
        275                 280                 285             


Ser Lys Phe Asp Gly Ile Glu Ile Leu Asn Ile Leu Phe Asn Gln Lys 
    290                 295                 300                 


Gln Glu Lys Tyr Phe Glu Ala Gln Thr Asn Tyr Ile Glu Glu Glu Thr 
305                 310                 315                 320 


Ile Lys Ile Leu Asp Glu Lys Glu Leu Ser Phe Lys Lys Leu His Ser 
                325                 330                 335     


Phe Tyr Ser Gln Ile Cys Gln Lys Lys Pro Ala Phe Asn Lys Leu Ile 
            340                 345                 350         


Asn Ser Phe Ile Ile Gln Asp Gly Ile Glu Asn Lys Glu Leu Lys Asp 
        355                 360                 365             


Tyr Ile Ser Gln Lys Tyr Asn Ser Lys Phe Asp Tyr Tyr Leu Asp Ile 
    370                 375                 380                 


His Thr Cys Lys Ile Tyr Lys Asp Ile Tyr Asn Gln His Lys Lys Phe 
385                 390                 395                 400 


Val Ala Asp Lys Gln Phe Leu Glu Asn Gln Lys Thr Asp Gly Gln Lys 
                405                 410                 415     


Ile Lys Lys Leu Asn Asp Gln Ile Asn Gln Leu Lys Thr Lys Met Asn 
            420                 425                 430         


Asn Leu Thr Lys Lys Asn Ser Leu Lys Arg Leu Glu Ile Lys Phe Arg 
        435                 440                 445             


Leu Ala Phe Gly Phe Ile Phe Thr Glu Tyr Gln Thr Phe Lys Asn Phe 
    450                 455                 460                 


Asn Glu Arg Phe Ile Glu Asp Ile Lys Ala Asn Lys Tyr Ser Thr Lys 
465                 470                 475                 480 


Ile Glu Leu Leu Asp Tyr Gly Lys Ile Lys Glu Tyr Ile Ser Ile Thr 
                485                 490                 495     


His Glu Glu Lys Arg Phe Phe Asn Tyr Lys Thr Phe Asn Lys Lys Thr 
            500                 505                 510         


Asn Lys Asn Ile Asn Lys Thr Ile Phe Gln Ser Leu Glu Lys Glu Thr 
        515                 520                 525             


Phe Glu Asn Leu Val Lys Asn Asp Asn Leu Ile Lys Met Met Phe Leu 
    530                 535                 540                 


Phe Gln Leu Leu Leu Pro Arg Glu Leu Lys Gly Glu Phe Leu Gly Phe 
545                 550                 555                 560 


Ile Leu Lys Ile Tyr His Asp Leu Lys Asn Ile Asp Asn Asp Thr Lys 
                565                 570                 575     


Pro Asp Glu Lys Ser Leu Ser Glu Leu Asn Ile Ser Thr Ala Leu Lys 
            580                 585                 590         


Leu Lys Ile Leu Val Lys Asn Ile Arg Gln Ile Asn Leu Phe Asn Tyr 
        595                 600                 605             


Thr Ile Ser Asn Asn Thr Lys Tyr Glu Glu Lys Glu Lys Arg Phe Tyr 
    610                 615                 620                 


Glu Glu Gly Asn Gln Trp Lys Asp Ile Tyr Lys Lys Leu Tyr Ile Ser 
625                 630                 635                 640 


His Asp Phe Asp Ile Phe Asp Ile His Leu Ile Ile Pro Ile Ile Lys 
                645                 650                 655     


Tyr Asn Ile Asn Leu Tyr Lys Leu Ile Gly Asp Phe Glu Val Tyr Leu 
            660                 665                 670         


Leu Leu Lys Tyr Leu Glu Arg Asn Thr Asn Tyr Lys Thr Leu Asp Lys 
        675                 680                 685             


Leu Ile Glu Ala Glu Glu Leu Lys Tyr Lys Gly Tyr Tyr Asn Phe Thr 
    690                 695                 700                 


Thr Leu Leu Ser Lys Ala Ile Asn Ile Ala Leu Asn Asp Lys Glu Tyr 
705                 710                 715                 720 


His Asn Ile Thr His Leu Arg Asn Asn Thr Ser His Gln Asp Ile Gln 
                725                 730                 735     


Asn Ile Ile Ser Ser Phe Lys Asn Asn Lys Leu Leu Glu Gln Arg Glu 
            740                 745                 750         


Asn Ile Ile Glu Leu Ile Ser Lys Glu Ser Leu Lys Lys Lys Leu His 
        755                 760                 765             


Phe Asp Pro Ile Asn Asp Phe Thr Met Lys Thr Leu Gln Leu Leu Lys 
    770                 775                 780                 


Ser Leu Glu Val His Ser Asp Lys Ser Glu Lys Ile Glu Asn Leu Leu 
785                 790                 795                 800 


Lys Lys Glu Pro Leu Leu Pro Asn Asp Val Tyr Leu Leu Tyr Lys Leu 
                805                 810                 815     


Lys Gly Ile Glu Phe Ile Lys Lys Glu Leu Ile Ser Asn Ile Gly Ile 
            820                 825                 830         


Thr Lys Tyr Glu Glu Lys Ile Gln Glu Lys Ile Ala Lys Gly Val Glu 
        835                 840                 845             


Lys 
    


<210> 253
<211> 608
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 253
Met Ile Lys Asn Pro Ala Asn Arg Tyr Ser Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Ser Glu Val Asp Ser Gln Asn Ile Leu Glu Phe Lys Ile Lys Tyr Glu 
            20                  25                  30          


Lys Leu Ala Arg Leu Asp Arg Phe Glu Val Lys Ala Met His Tyr Asp 
        35                  40                  45              


Asp Gly Glu Ile Val Phe Asp Glu Val Leu Val Asn Gly Gly Lys Leu 
    50                  55                  60                  


Asp Val Glu Tyr Gln Asp Glu His Lys Thr Leu Leu Val Lys Ile Glu 
65                  70                  75                  80  


Gly Lys Glu Tyr Ser Ile Lys Gly Gln Lys Ile Gly Gly Lys Gln Arg 
                85                  90                  95      


Leu Leu Glu Asn Arg Ile Ser Lys Ser Lys Val Gln Leu Thr Ile Lys 
            100                 105                 110         


Asp Asn Ile Gln Thr Asn Ala Asn Gly Thr Ala Arg Gln Lys Ser Thr 
        115                 120                 125             


Glu Arg Glu Phe Ile Val Pro Glu Asn Ile Lys Leu Tyr Ser Gln Ile 
    130                 135                 140                 


Val Gly Arg Glu Ile Thr Thr Thr Lys Glu Ile Tyr Leu Thr Lys Arg 
145                 150                 155                 160 


Phe Leu Gly Tyr Arg Ser Asp Leu Leu Phe Tyr Tyr Gly Phe Val Asp 
                165                 170                 175     


Asn Phe Phe Gln Val Ala Asp Asn Lys Lys Glu Leu Trp Lys Ile Asp 
            180                 185                 190         


Phe Gln Asn Ser Gln Phe Ala Asp Tyr Phe Gln Tyr Met Val Asn Asp 
        195                 200                 205             


Asn Leu Lys Asn Ser Asp Asn Tyr Leu Lys Asp Tyr Leu Asn Asp Ser 
    210                 215                 220                 


Ser Lys Ile Thr Asp Asp Leu Glu Lys Val Lys Thr Val Phe Ser Lys 
225                 230                 235                 240 


Leu Arg His Ala Leu Leu His Phe Glu Tyr Asp Phe Phe Glu Lys Leu 
                245                 250                 255     


Phe Asn Gly Glu Asp Val Gly Phe Asp Leu Asp Ile Gly Phe Leu Asn 
            260                 265                 270         


Leu Leu Ile Glu Asn Ile Asp Lys Leu Asn Ile Asp Ala Lys Lys Glu 
        275                 280                 285             


Phe Ile Ala Asp Glu Lys Ile Lys Leu Phe Gly Glu Glu Leu Ala Leu 
    290                 295                 300                 


Ser Lys Val Tyr Ala Leu Tyr Ser Ser Ile Cys Val Asn Arg Val Gly 
305                 310                 315                 320 


Phe Asn Lys Phe Ile Asn Ser Leu Ile Met Val Asp Gly Val Glu Asn 
                325                 330                 335     


Glu Thr Leu Lys Ser Phe Phe Asp Asp Glu Leu Lys Glu Lys Asn Pro 
            340                 345                 350         


Arg Leu Phe Glu Ala Leu Gly Asn Arg Ala Tyr Tyr Val Asp Ile His 
        355                 360                 365             


Ser Asn Arg Ala Tyr Lys Arg Ile Tyr Asn Gln His Lys Glu Leu Val 
    370                 375                 380                 


Ser Lys Ser Ser Ala Leu Ser Asp Gly Arg Lys Ile His Gln Ala Asn 
385                 390                 395                 400 


Gln Glu Ile Thr Lys Leu Lys Glu Lys Met Asn Glu Ile Thr Lys Arg 
                405                 410                 415     


Asn Ser Leu Ala Arg Leu Glu His Lys Leu Arg Val Ala Phe Gly Phe 
            420                 425                 430         


Leu Tyr Gly Glu Tyr Asn Asp His Arg Ala Phe Lys Asp Asn Phe Asp 
        435                 440                 445             


Thr Asp Ile Lys Ser Lys Lys Phe Glu Thr Leu Asn Ser Asp Lys Ser 
    450                 455                 460                 


Lys Asp Tyr Phe Ser Ser Thr Tyr Gln Asn Arg Lys Pro Arg Thr Arg 
465                 470                 475                 480 


Glu Lys Leu Glu Lys Val Glu Ser Leu Asn Leu Lys Thr Leu Ile Glu 
                485                 490                 495     


Asp Asp Arg Leu Leu Lys Phe Val Leu Leu Met Phe Leu Phe Met Pro 
            500                 505                 510         


Gln Glu Val Lys Gly Glu Phe Ile Gly Phe Ile Lys Lys Tyr Tyr His 
        515                 520                 525             


Asp Thr Lys Gly Ile Gly Glu Asp Thr Lys Glu Lys Glu Leu Asp Val 
    530                 535                 540                 


Val Glu Thr Met Pro Leu Ser Leu Lys Leu Lys Ile Leu Gly Asn Asn 
545                 550                 555                 560 


Ile Arg Ser Leu Thr Leu Phe Lys Tyr Ala Leu Ser Ser Glu Val Lys 
                565                 570                 575     


Tyr Asn Ser Ser Ser His Leu Phe Tyr Glu Glu Gly Asn Arg His Gly 
            580                 585                 590         


Arg Ile Tyr Lys Lys Leu Gly Ile Ser His Asn Gln Glu Glu Phe Asn 
        595                 600                 605             


<210> 254
<211> 832
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 254
Met Ile Lys Asn Pro Ser Asn Arg Tyr Ala Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Ser Lys Ile Asp Asn Gln Asn Ile Leu Glu Phe Lys Ile Lys Tyr Lys 
            20                  25                  30          


Lys Leu Ser Lys Leu Asp Ile Val Lys Val Lys Ser Met His Tyr Asp 
        35                  40                  45              


Asp Arg Ala Ile Ile Phe Asp Glu Val Ile Val Asn Asp Gly Leu Ile 
    50                  55                  60                  


Asp Val Glu Tyr Arg Asp Asn His Lys Thr Ile Phe Val Lys Val Gly 
65                  70                  75                  80  


Asn Lys Ser Tyr Ser Ile Ser Gly Gln Lys Val Gly Gly Lys Glu Arg 
                85                  90                  95      


Leu Leu Glu Asn Arg Val Ser Lys Thr Lys Val Gln Leu Glu Leu Lys 
            100                 105                 110         


Asp Lys Ala Thr Asn Arg Val Ser Lys Thr Glu Arg Glu Leu Ile Val 
        115                 120                 125             


Asp Asp Asn Ile Lys Ile Tyr Ser Gln Ile Val Gly Arg Asp Val Lys 
    130                 135                 140                 


Thr Thr Lys Asp Ile Tyr Leu Ile Lys Arg Phe Leu Ala Tyr Arg Ser 
145                 150                 155                 160 


Asp Leu Leu Phe Tyr Tyr Gly Phe Val Asn Asn Phe Phe His Val Ala 
                165                 170                 175     


Asn Asn Arg Ser Glu Phe Trp Lys Ile Asp Phe Asn Asp Ser Asn Asn 
            180                 185                 190         


Ser Lys Leu Ile Glu Tyr Phe Lys Phe Thr Ile Asn Asp His Leu Lys 
        195                 200                 205             


Asn Asp Glu Asn Tyr Leu Lys Asp Tyr Ile Ser Asp Asn Glu Lys Leu 
    210                 215                 220                 


Lys Asn Asp Leu Ile Lys Val Lys Asn Ser Phe Glu Lys Ile Arg His 
225                 230                 235                 240 


Ala Leu Met His Phe Asp Tyr Asp Phe Phe Val Lys Leu Phe Asn Gly 
                245                 250                 255     


Glu Asp Val Gly Leu Glu Leu Asp Ile Glu Phe Leu Asp Ile Met Ile 
            260                 265                 270         


Asp Lys Leu Asp Lys Leu Asn Ile Asp Thr Lys Lys Glu Phe Ile Asp 
        275                 280                 285             


Asp Glu Lys Ile Thr Ile Phe Gly Glu Glu Leu Ser Leu Ala Lys Leu 
    290                 295                 300                 


Tyr Arg Phe Tyr Ala His Thr Ala Ile Asn Arg Val Ala Phe Asn Lys 
305                 310                 315                 320 


Leu Ile Asn Ser Phe Ile Ile Glu Asn Gly Val Glu Asn Gln Ser Leu 
                325                 330                 335     


Lys Glu Tyr Phe Asn Gln Gln Ala Gly Gly Ile Ala Tyr Glu Ile Asp 
            340                 345                 350         


Ile His Gln Asn Arg Glu Tyr Lys Asn Leu Tyr Asn Glu His Lys Lys 
        355                 360                 365             


Leu Val Ser Arg Val Leu Ser Ile Ser Asp Gly Gln Glu Ile Ala Ile 
    370                 375                 380                 


Leu Asn Gln Lys Ile Ala Lys Leu Lys Asp Gln Met Lys Gln Ile Thr 
385                 390                 395                 400 


Lys Ala Asn Ser Ile Lys Arg Leu Glu Tyr Lys Leu Arg Leu Ala Leu 
                405                 410                 415     


Gly Phe Ile Tyr Thr Glu Tyr Glu Asn Tyr Glu Glu Phe Lys Asn Asn 
            420                 425                 430         


Phe Asp Thr Asp Ile Lys Asn Gly Arg Phe Thr Pro Lys Asp Asn Asp 
        435                 440                 445             


Gly Asn Lys Arg Ala Phe Asp Ser Arg Glu Leu Glu Gln Leu Lys Gly 
    450                 455                 460                 


Tyr Tyr Glu Ala Thr Ile Gln Thr Gln Lys Pro Lys Thr Asp Glu Lys 
465                 470                 475                 480 


Ile Glu Glu Val Ser Lys Lys Ile Asp Arg Leu Ser Leu Lys Ser Leu 
                485                 490                 495     


Ile Ala Asp Asp Ile Leu Leu Lys Phe Ile Leu Leu Met Phe Thr Phe 
            500                 505                 510         


Met Pro Gln Glu Leu Lys Gly Glu Phe Leu Gly Phe Ile Lys Lys Tyr 
        515                 520                 525             


Tyr His Asp Thr Lys His Ile Asp Gln Asp Thr Ile Ser Asp Ser Asp 
    530                 535                 540                 


Asp Thr Ile Glu Thr Leu Ser Ile Gly Leu Lys Leu Lys Ile Leu Asp 
545                 550                 555                 560 


Lys Asn Ile Arg Ser Leu Ser Ile Leu Lys His Ser Leu Ser Phe Gln 
                565                 570                 575     


Thr Lys Tyr Asn Lys Lys Asp Arg Asn Tyr Tyr Glu Asp Gly Asn Ile 
            580                 585                 590         


His Gly Lys Phe Phe Lys Lys Leu Gly Ile Ser His Asn Gln Glu Glu 
        595                 600                 605             


Phe Asn Lys Ser Val Tyr Ala Pro Leu Phe Arg Tyr Tyr Ser Ala Leu 
    610                 615                 620                 


Tyr Lys Leu Ile Asn Asp Phe Glu Ile Tyr Thr Leu Ser Leu His Ile 
625                 630                 635                 640 


Val Gly Ser Glu Thr Leu Thr Asp Gln Val Asn Lys Ser Gln Phe Leu 
                645                 650                 655     


Ser Gly Arg Tyr Phe Asn Phe Arg Lys Leu Leu Thr Gln Ser Tyr His 
            660                 665                 670         


Ile Asn Asn Asn Ser Thr His Ser Thr Ile Phe Asn Ala Val Ile Asn 
        675                 680                 685             


Met Arg Asn Asp Ile Ser His Leu Ser Tyr Glu Pro Leu Phe Asp Cys 
    690                 695                 700                 


Pro Leu Asn Gly Lys Lys Ser Tyr Lys Arg Lys Ile Arg Asn Gln Phe 
705                 710                 715                 720 


Lys Thr Ile Asn Ile Lys Pro Leu Val Glu Ser Arg Lys Ile Ile Ile 
                725                 730                 735     


Asp Phe Ile Thr Leu Gln Thr Asp Met Gln Lys Val Leu Gly Tyr Asp 
            740                 745                 750         


Ala Val Asn Asp Phe Thr Met Lys Ile Val Gln Leu Arg Thr Arg Leu 
        755                 760                 765             


Lys Ala Tyr Ala Asn Lys Glu Gln Thr Ile Gln Lys Met Ile Thr Glu 
    770                 775                 780                 


Ala Lys Thr Pro Asn Asp Phe Tyr Asn Ile Tyr Lys Val Gln Gly Val 
785                 790                 795                 800 


Glu Glu Ile Asn Lys Tyr Leu Leu Glu Val Ile Gly Glu Thr Gln Ala 
                805                 810                 815     


Glu Lys Glu Ile Arg Glu Lys Ile Glu Arg Gly Asn Ile Ala Asn Phe 
            820                 825                 830         


<210> 255
<211> 802
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 255
Met Leu Lys Lys Pro Ser Asn Arg Tyr Ala Leu Pro Lys Val Ile Leu 
1               5                   10                  15      


Ser Thr Val Asp His Glu Lys Ile Leu Glu Phe Lys Val Lys Tyr Glu 
            20                  25                  30          


Lys Leu Ala Arg Leu Asp Arg Leu Val Val Glu Arg Met His Phe Asp 
        35                  40                  45              


Gly Glu Ser Val Val Phe Asp Glu Val Ile Ala Asn Ser Gly Asp Leu 
    50                  55                  60                  


Glu Ile Ala Tyr Gln Asp Asp His Arg Lys Leu Leu Ile Gln Ala Ala 
65                  70                  75                  80  


Gly Lys Ser Tyr Thr Ile Thr Gly Lys Lys Val Gly Gly Lys Lys Arg 
                85                  90                  95      


Lys Leu Glu Glu Arg Ile Ser Arg Ala Lys Ile Gln Leu Thr Leu Thr 
            100                 105                 110         


Asp Gly Gln Glu Asp Gln His Arg Arg Ile Arg Ala Thr Val Thr Glu 
        115                 120                 125             


Lys Ala Leu Leu Glu Pro Lys Glu Asp Arg Asp Ile Tyr Ser Lys Ile 
    130                 135                 140                 


Ser Asp Arg Lys Ile Lys Thr Ser Lys Glu Ile Tyr Leu Val Lys Arg 
145                 150                 155                 160 


Phe Leu Ser Tyr Arg Ser Asp Leu Leu Phe Tyr Tyr Phe Phe Val Asp 
                165                 170                 175     


Asn Phe Phe Lys Val Gly Asn Asn Lys Gln Glu Leu Trp Lys Ile Lys 
            180                 185                 190         


Phe Gln Asn Gln Pro Glu Leu Ile Glu Tyr Phe Arg Phe Ile Ile Asn 
        195                 200                 205             


Asp Arg Phe Lys Asn Ala Lys Asn Asp Lys Phe Asp Asn Tyr Leu Lys 
    210                 215                 220                 


Asn Asp Lys Ala Ile Gln Glu Asp Leu Glu Lys Ile Gln Lys Val Phe 
225                 230                 235                 240 


Glu Lys Leu Arg His Ala Leu Met His Tyr Asp Tyr Gly Phe Phe Glu 
                245                 250                 255     


Lys Leu Phe Gly Gly Glu Asp Gln Gly Phe Asp Leu Asp Ile Ala Phe 
            260                 265                 270         


Leu Asp Asn Phe Val Lys Lys Ile Asp Lys Leu Asn Ile Asp Thr Lys 
        275                 280                 285             


Lys Glu Phe Val Asp Asp Glu Lys Ile Lys Ile Phe Gly Glu Asp Leu 
    290                 295                 300                 


Asn Leu Ala Asp Leu Tyr Lys Leu Tyr Ala Ser Ile Ser Ile Asn Arg 
305                 310                 315                 320 


Val Gly Phe Asn Arg Val Val Asn Glu Met Ile Ile Lys Asp Gly Ile 
                325                 330                 335     


Glu Lys Ser Glu Leu Lys Arg Ala Phe Glu Lys Lys Leu Asp Lys Thr 
            340                 345                 350         


Tyr Ala Leu Asp Ile His Ser Asp Pro Ser Tyr Lys Lys Leu Tyr Asn 
        355                 360                 365             


Glu His Lys Arg Leu Val Thr Glu Val Ser Thr Tyr Thr Asp Gly Asn 
    370                 375                 380                 


Lys Ile Lys Glu Gly Asn Gln Lys Ile Ala Lys Leu Lys Tyr Glu Met 
385                 390                 395                 400 


Lys Glu Ile Thr Lys Lys Asn Ala Leu Val Arg Leu Glu Cys Lys Met 
                405                 410                 415     


Arg Leu Ala Phe Gly Leu Ile Tyr Gly Arg Tyr Asp Thr His Glu Ala 
            420                 425                 430         


Phe Lys Asn Gly Phe Asp Thr Asp Leu Lys Arg Gly Glu Phe Ala Gln 
        435                 440                 445             


Ile Gly Ser Glu Glu Ala Ile Gly Tyr Phe Asn Thr Thr Phe Glu Lys 
    450                 455                 460                 


Ser Lys Pro Lys Ser Lys Glu Glu Ile Lys Lys Ile Ala Arg Gln Ile 
465                 470                 475                 480 


Asp Asn Leu Ser Leu Ser Thr Leu Ile Glu Asp Asp Pro Leu Met Lys 
                485                 490                 495     


Phe Ile Val Leu Met Phe Leu Phe Val Pro Arg Glu Leu Lys Gly Glu 
            500                 505                 510         


Phe Leu Gly Phe Trp Arg Lys Tyr Tyr His Asp Ile His Ser Ile Asp 
        515                 520                 525             


Ser Asp Ala Lys Ser Asp Glu Met Pro Asp Glu Val Ser Leu Ser Leu 
    530                 535                 540                 


Lys Leu Lys Ile Leu Thr Arg Asn Ile Arg Arg Leu Asn Leu Phe Glu 
545                 550                 555                 560 


Tyr Ser Leu Ser Glu Lys Ile Lys Tyr Ser Pro Lys Asn Thr Gln Phe 
                565                 570                 575     


Tyr Thr Asp Lys Ser Pro Tyr Gln Lys Val Tyr Lys Arg Leu Lys Ile 
            580                 585                 590         


Ser His Asn Lys Glu Glu Phe Asp Lys Thr Leu Leu Val Pro Leu Phe 
        595                 600                 605             


Arg Tyr Tyr Ser Ile Leu Phe Lys Leu Ile Asn Asp Phe Glu Ile Tyr 
    610                 615                 620                 


Ser Leu Ala Lys Ala Asn Pro Asp Ala Ser Ser Leu Ser Glu Leu Thr 
625                 630                 635                 640 


Lys Thr Lys His Gly Phe Arg Gly His Tyr Asn Phe Thr Thr Leu Met 
                645                 650                 655     


Met Asp Ala His Lys Val Ser Gln Gly Asp Ser Lys Lys His Phe Gly 
            660                 665                 670         


Ile Arg Gly Glu Ile Ala His Ile Asn Thr Lys Asp Leu Ile Tyr Asp 
        675                 680                 685             


Pro Leu Phe Arg Lys Ser Lys Met Ala Gln Gln Arg Asn Asp Val Ile 
    690                 695                 700                 


Asp Phe Val Leu Lys Tyr Glu Lys Glu Ile Lys Ala Val Leu Gly Tyr 
705                 710                 715                 720 


Asp Ala Ile Asn Asp Phe Arg Met Lys Val Val Gln Leu Arg Thr Lys 
                725                 730                 735     


Leu Lys Val Tyr Ser Asp Lys Thr Gln Thr Ile Glu Lys Leu Leu Asn 
            740                 745                 750         


Glu Val Glu Ala Pro Asp Asp Phe Tyr Val Leu Tyr Lys Val Lys Gly 
        755                 760                 765             


Val Glu Ala Ile Asn Lys Tyr Leu Leu Glu Ile Val Ser Val Thr Gln 
    770                 775                 780                 


Ala Glu Glu Glu Ile Glu Arg Lys Ile Ile Thr Gly Asn Lys Arg Tyr 
785                 790                 795                 800 


Asn Thr 
        


<210> 256
<211> 806
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 256
Met Thr Lys Lys Pro Ser Asn Arg Asn Ser Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Asn Lys Val Asp Glu Ser Ser Ile Leu Glu Phe Lys Ile Lys Tyr Glu 
            20                  25                  30          


Lys Leu Ala Arg Leu Asp Arg Phe Glu Val Arg Ser Met Arg Tyr Asp 
        35                  40                  45              


Gly Asp Gly Arg Ile Ile Phe Asp Glu Val Val Ala Asn Ala Gly Leu 
    50                  55                  60                  


Leu Asp Val Asp Tyr Glu Asp Asp Asn Arg Thr Ile Val Val Lys Ile 
65                  70                  75                  80  


Glu Asn Lys Ala Tyr Asn Ile Tyr Gly Lys Lys Val Gly Gly Glu Lys 
                85                  90                  95      


Arg Leu Asn Gly Lys Ile Ser Lys Ala Lys Val Gln Leu Ile Leu Thr 
            100                 105                 110         


Asp Ser Ile Arg Lys Asn Ala Asn Asp Thr His Arg His Ser Leu Thr 
        115                 120                 125             


Glu Arg Glu Leu Ile Asn Lys Asn Glu Val Asp Leu Tyr Ser Lys Ile 
    130                 135                 140                 


Ala Glu Arg Glu Ile Ser Thr Thr Lys Asp Ile Tyr Leu Val Lys Arg 
145                 150                 155                 160 


Phe Leu Ala Tyr Arg Ser Asp Leu Leu Leu Tyr Tyr Ala Phe Ile Asn 
                165                 170                 175     


His Tyr Val Arg Val Asn Gly Asn Lys Lys Glu Phe Trp Lys Thr Glu 
            180                 185                 190         


Ile Asp Asp Lys Ile Ile Asp Tyr Phe Ile Tyr Thr Ile Asn Asp Thr 
        195                 200                 205             


Leu Lys Asn Lys Glu Gly Tyr Leu Glu Lys Tyr Ile Val Asp Arg Asp 
    210                 215                 220                 


Gln Ile Lys Lys Asp Leu Glu Lys Ile Lys Gln Ile Phe Ser His Leu 
225                 230                 235                 240 


Arg His Lys Leu Met His Tyr Asp Phe Arg Phe Phe Thr Asp Leu Phe 
                245                 250                 255     


Asp Gly Lys Asp Val Asp Ile Lys Val Asp Asn Ser Ile Gln Lys Ile 
            260                 265                 270         


Ser Glu Leu Leu Asp Ile Glu Phe Leu Asn Ile Val Ile Asp Lys Leu 
        275                 280                 285             


Glu Lys Leu Asn Ile Asp Ala Lys Lys Glu Phe Ile Asp Asp Glu Lys 
    290                 295                 300                 


Ile Thr Leu Phe Gly Gln Glu Ile Glu Leu Lys Lys Leu Tyr Ser Leu 
305                 310                 315                 320 


Tyr Ala His Thr Ser Ile Asn Arg Val Ala Phe Asn Lys Leu Ile Asn 
                325                 330                 335     


Ser Phe Leu Ile Lys Asp Gly Val Glu Asn Lys Glu Leu Lys Glu Tyr 
            340                 345                 350         


Phe Asn Ala His Asn Gln Gly Lys Glu Ser Tyr Tyr Ile Asp Ile His 
        355                 360                 365             


Gln Asn Gln Glu Tyr Lys Lys Leu Tyr Ile Glu His Lys Asn Leu Val 
    370                 375                 380                 


Ala Lys Leu Ser Ala Thr Thr Asp Gly Lys Glu Ile Ala Lys Ile Asn 
385                 390                 395                 400 


Arg Glu Leu Ala Asp Lys Lys Glu Gln Met Lys Gln Ile Thr Lys Ala 
                405                 410                 415     


Asn Ser Leu Lys Arg Leu Glu Tyr Lys Leu Arg Leu Ala Phe Gly Phe 
            420                 425                 430         


Ile Tyr Thr Glu Tyr Lys Asp Tyr Glu Arg Phe Lys Asn Ser Phe Asp 
        435                 440                 445             


Thr Asp Thr Lys Lys Lys Lys Phe Asp Ala Ile Asp Asn Ala Lys Ile 
    450                 455                 460                 


Ile Glu Tyr Phe Glu Ala Thr Asn Lys Ala Lys Lys Ile Glu Lys Leu 
465                 470                 475                 480 


Glu Glu Ile Leu Lys Gly Ile Asp Lys Leu Ser Leu Lys Thr Leu Ile 
                485                 490                 495     


Gln Asp Asp Ile Leu Leu Lys Phe Leu Leu Leu Phe Phe Thr Phe Leu 
            500                 505                 510         


Pro Gln Glu Ile Lys Gly Glu Phe Leu Gly Phe Ile Lys Lys Tyr Tyr 
        515                 520                 525             


His Asp Ile Thr Ser Leu Asp Glu Asp Thr Lys Asp Lys Asp Asp Glu 
    530                 535                 540                 


Ile Thr Glu Leu Pro Arg Ser Leu Lys Leu Lys Ile Phe Ser Lys Asn 
545                 550                 555                 560 


Ile Arg Lys Leu Ser Ile Leu Lys His Ser Leu Ser Tyr Gln Ile Lys 
                565                 570                 575     


Tyr Asn Lys Lys Glu Ser Ser Tyr Tyr Glu Ala Gly Asn Val Phe Asn 
            580                 585                 590         


Lys Met Phe Lys Lys Gln Ala Ile Ser His Asn Leu Glu Glu Phe Gly 
        595                 600                 605             


Lys Ser Ile Tyr Leu Pro Met Leu Lys Tyr Tyr Ser Ala Leu Tyr Lys 
    610                 615                 620                 


Leu Ile Asn Asp Phe Glu Ile Tyr Ala Leu Tyr Lys Asp Met Asp Thr 
625                 630                 635                 640 


Ser Glu Thr Leu Ser Gln Gln Val Asp Lys Gln Glu Tyr Lys Arg Asn 
                645                 650                 655     


Glu Tyr Phe Asn Phe Glu Thr Leu Leu Arg Lys Lys Phe Gly Asn Asp 
            660                 665                 670         


Ile Glu Lys Val Leu Val Thr Tyr Arg Asn Lys Ile Ala His Leu Asp 
        675                 680                 685             


Phe Asn Phe Leu Tyr Asp Lys Pro Ile Asn Lys Phe Ile Ser Leu Tyr 
    690                 695                 700                 


Lys Ser Arg Glu Lys Ile Val Asn Tyr Ile Lys Asn His Asp Ile Gln 
705                 710                 715                 720 


Ala Val Leu Lys Tyr Asp Ala Val Asn Asp Phe Val Met Lys Val Ile 
                725                 730                 735     


Gln Leu Arg Thr Lys Leu Lys Val Tyr Ala Asp Lys Glu Gln Thr Ile 
            740                 745                 750         


Glu Ser Met Ile Gln Asn Thr Gln Asn Pro Asn Gly Phe Tyr Asn Ile 
        755                 760                 765             


Tyr Lys Val Lys Ala Val Glu Asn Ile Asn Arg His Leu Leu Lys Val 
    770                 775                 780                 


Ile Gly Tyr Thr Glu Ser Glu Lys Ala Val Glu Glu Lys Ile Arg Ala 
785                 790                 795                 800 


Gly Asn Thr Ser Lys Ser 
                805     


<210> 257
<211> 835
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 257
Met Glu Lys Ile Lys Lys Pro Ser Asn Arg Asn Ser Ile Pro Ser Ile 
1               5                   10                  15      


Ile Ile Ser Asp Tyr Asp Ala Asn Lys Ile Lys Glu Ile Lys Val Lys 
            20                  25                  30          


Tyr Leu Lys Leu Ala Arg Leu Asp Lys Ile Thr Ile Gln Asp Met Glu 
        35                  40                  45              


Ile Val Asp Asn Ile Val Glu Phe Lys Lys Ile Leu Leu Asn Gly Val 
    50                  55                  60                  


Glu His Thr Ile Ile Asp Asn Gln Lys Ile Glu Phe Asp Asn Tyr Glu 
65                  70                  75                  80  


Ile Thr Gly Cys Ile Lys Pro Ser Asn Lys Arg Arg Asp Gly Arg Ile 
                85                  90                  95      


Ser Gln Ala Lys Tyr Val Val Thr Ile Thr Asp Lys Tyr Leu Arg Glu 
            100                 105                 110         


Asn Glu Lys Glu Lys Arg Phe Lys Ser Thr Glu Arg Glu Leu Pro Asn 
        115                 120                 125             


Asn Thr Leu Leu Ser Arg Tyr Lys Gln Ile Ser Gly Phe Asp Thr Leu 
    130                 135                 140                 


Thr Ser Lys Asp Ile Tyr Lys Ile Lys Arg Tyr Ile Asp Phe Lys Asn 
145                 150                 155                 160 


Glu Met Leu Phe Tyr Phe Gln Phe Ile Glu Glu Phe Phe Asn Pro Leu 
                165                 170                 175     


Leu Pro Lys Gly Lys Asn Phe Tyr Asp Leu Asn Ile Glu Gln Asn Lys 
            180                 185                 190         


Asp Lys Val Ala Lys Phe Ile Val Tyr Arg Leu Asn Asp Asp Phe Lys 
        195                 200                 205             


Asn Lys Ser Leu Asn Ser Tyr Ile Thr Asp Thr Cys Met Ile Ile Asn 
    210                 215                 220                 


Asp Phe Lys Lys Ile Gln Lys Ile Leu Ser Asp Phe Arg His Ala Leu 
225                 230                 235                 240 


Ala His Phe Asp Phe Asp Phe Ile Gln Lys Phe Phe Asp Asp Gln Leu 
                245                 250                 255     


Asp Lys Asn Lys Phe Asp Ile Asn Thr Ile Ser Leu Ile Glu Thr Leu 
            260                 265                 270         


Leu Asp Gln Lys Glu Glu Lys Asn Tyr Gln Glu Lys Asn Asn Tyr Ile 
        275                 280                 285             


Asp Asp Asn Asp Ile Leu Thr Ile Phe Asp Glu Lys Gly Ser Lys Phe 
    290                 295                 300                 


Ser Lys Leu His Asn Phe Tyr Thr Lys Ile Ser Gln Lys Lys Pro Ala 
305                 310                 315                 320 


Phe Asn Lys Leu Ile Asn Ser Phe Leu Ser Gln Asp Gly Val Pro Asn 
                325                 330                 335     


Glu Glu Phe Lys Ser Tyr Leu Val Thr Lys Lys Leu Asp Phe Phe Glu 
            340                 345                 350         


Asp Ile His Ser Asn Lys Glu Tyr Lys Lys Ile Tyr Ile Gln His Lys 
        355                 360                 365             


Asn Leu Val Ile Lys Lys Gln Lys Glu Glu Ser Gln Glu Lys Pro Asp 
    370                 375                 380                 


Gly Gln Lys Leu Lys Asn Tyr Asn Asp Glu Leu Gln Lys Leu Lys Asp 
385                 390                 395                 400 


Glu Met Asn Thr Ile Thr Lys Gln Asn Ser Leu Asn Arg Leu Glu Val 
                405                 410                 415     


Lys Leu Arg Leu Ala Phe Gly Phe Ile Ala Asn Glu Tyr Asn Tyr Asn 
            420                 425                 430         


Phe Lys Asn Phe Asn Asp Glu Phe Thr Asn Asp Val Lys Asn Glu Gln 
        435                 440                 445             


Lys Ile Lys Ala Phe Lys Asn Ser Ser Asn Glu Lys Leu Lys Glu Tyr 
    450                 455                 460                 


Phe Glu Ser Thr Phe Ile Glu Lys Arg Phe Phe His Phe Ser Val Asn 
465                 470                 475                 480 


Phe Phe Asn Lys Lys Thr Lys Lys Glu Glu Thr Lys Gln Lys Asn Ile 
                485                 490                 495     


Phe Asn Ser Ile Glu Asn Glu Thr Leu Glu Glu Leu Val Lys Glu Ser 
            500                 505                 510         


Pro Leu Leu Gln Ile Ile Thr Leu Leu Tyr Leu Phe Ile Pro Arg Glu 
        515                 520                 525             


Leu Gln Gly Glu Phe Val Gly Phe Ile Leu Lys Ile Tyr His His Thr 
    530                 535                 540                 


Lys Asn Ile Thr Ser Asp Thr Lys Glu Asp Glu Ile Ser Ile Glu Asp 
545                 550                 555                 560 


Ala Gln Asn Ser Phe Ser Leu Lys Phe Lys Ile Leu Ala Lys Asn Leu 
                565                 570                 575     


Arg Gly Leu Gln Leu Phe His Tyr Ser Leu Ser His Asn Thr Leu Tyr 
            580                 585                 590         


Asn Asn Lys Gln Cys Phe Phe Tyr Glu Lys Gly Asn Arg Trp Gln Ser 
        595                 600                 605             


Val Tyr Lys Ser Phe Gln Ile Ser His Asn Gln Asp Glu Phe Asp Ile 
    610                 615                 620                 


His Leu Val Ile Pro Val Ile Lys Tyr Tyr Ile Asn Leu Asn Lys Leu 
625                 630                 635                 640 


Met Gly Asp Phe Glu Ile Tyr Ala Leu Leu Lys Tyr Ala Asp Lys Asn 
                645                 650                 655     


Ser Ile Thr Val Lys Leu Ser Asp Ile Thr Ser Arg Asp Asp Leu Lys 
            660                 665                 670         


Tyr Asn Gly His Tyr Asn Phe Ala Thr Leu Leu Phe Lys Thr Phe Gly 
        675                 680                 685             


Ile Asp Thr Asn Tyr Lys Gln Asn Lys Val Ser Ile Gln Asn Ile Lys 
    690                 695                 700                 


Lys Thr Arg Asn Asn Leu Ala His Gln Asn Ile Glu Asn Met Leu Lys 
705                 710                 715                 720 


Ala Phe Glu Asn Ser Glu Ile Phe Ala Gln Arg Glu Glu Ile Val Asn 
                725                 730                 735     


Tyr Leu Gln Thr Glu His Arg Met Gln Glu Val Leu His Tyr Asn Pro 
            740                 745                 750         


Ile Asn Asp Phe Thr Met Lys Thr Val Gln Tyr Leu Lys Ser Leu Ser 
        755                 760                 765             


Val His Ser Gln Lys Glu Gly Lys Ile Ala Asp Ile His Lys Lys Glu 
    770                 775                 780                 


Ser Leu Val Pro Asn Asp Tyr Tyr Leu Ile Tyr Lys Leu Lys Ala Ile 
785                 790                 795                 800 


Glu Leu Leu Lys Gln Lys Val Ile Glu Val Ile Gly Glu Ser Glu Asp 
                805                 810                 815     


Glu Lys Lys Ile Lys Asn Ala Ile Ala Lys Glu Glu Gln Ile Lys Lys 
            820                 825                 830         


Gly Asn Asn 
        835 


<210> 258
<211> 847
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 258
Met Met Thr Lys Lys Pro Ala Asn Arg His Ala Leu Pro Lys Val Ile 
1               5                   10                  15      


Ile Ser Glu Val Asp Asn Thr Asn Ile Leu Glu Phe Lys Ile Lys Tyr 
            20                  25                  30          


Glu Lys Leu Ala Arg Leu Asp Arg Val Glu Val Lys Ala Met His Tyr 
        35                  40                  45              


Glu Asp Gly Arg Ile Ile Phe Asp Glu Val Val Val Asn Gly Gly Leu 
    50                  55                  60                  


Ile Glu Val Glu Tyr Gln Asp Asp His Lys Thr Leu Phe Val Gln Val 
65                  70                  75                  80  


Gly Glu Lys Ser Tyr Ser Ile Ser Gly Gln Lys Val Gly Gly Lys Gln 
                85                  90                  95      


Arg Leu Leu Glu Asp Arg Val Ser Lys Thr Lys Val Gln Leu Glu Leu 
            100                 105                 110         


Ser Asp Gly Ser Ser Glu Arg Val Ser Arg Thr Glu Arg Glu Leu Ile 
        115                 120                 125             


Val Ala Asp Asn Ile Lys Leu Tyr Ser Gln Ile Val Gly His Glu Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ile Tyr Leu Ala Lys Arg Phe Leu Gly Tyr Arg 
145                 150                 155                 160 


Ser Asp Leu Leu Phe Tyr Tyr Gly Phe Val Asp Asn Phe Phe Arg Glu 
                165                 170                 175     


Ser Lys Asn Leu Lys Tyr Gly Lys Gln Pro Val Glu Leu Trp Glu Asp 
            180                 185                 190         


Lys Phe Gln Val Asn Asp Lys Leu Thr Ala Tyr Thr Lys Phe Met Phe 
        195                 200                 205             


Asn Asp Asp Leu Gln Asn Ser Glu Ser Tyr Leu Lys Glu Tyr Val Lys 
    210                 215                 220                 


Asp Asn His Lys Ile Lys Asn Asp Leu Glu Ser Ala Arg Asp Ile Phe 
225                 230                 235                 240 


Ala Thr Phe Arg His Asn Leu Met His Phe Asn Tyr Ser Phe Phe Thr 
                245                 250                 255     


Arg Leu Phe Asn Gly Glu Asp Val Lys Ile Lys Asn Leu Gln Thr Lys 
            260                 265                 270         


Lys Phe Glu Ser Leu Ser Asp Val Leu Arg Asn Val Glu Phe Leu Asn 
        275                 280                 285             


Lys Val Ile Gln Ser Ile Asp Lys Leu Asn Ile Asp Thr Arg Lys Glu 
    290                 295                 300                 


Phe Ile Asp Lys Glu Lys Ile Thr Leu Phe Asn Glu Glu Leu Asp Leu 
305                 310                 315                 320 


Gln Gln Leu Tyr Gly Phe Phe Ala Tyr Thr Ala Ile Asn Arg Val Ala 
                325                 330                 335     


Phe Asn Lys Leu Ile Asn Ser Phe Ile Ile Lys Asp Gly Ile Glu Asn 
            340                 345                 350         


Glu Gln Leu Lys Glu Tyr Phe Asn Gln Arg Val Asp Gly Thr Ala Tyr 
        355                 360                 365             


Glu Ile Asp Ile His Gln Asn Arg Glu Tyr Lys Glu Leu Tyr Lys Lys 
    370                 375                 380                 


His Lys Asn Leu Val Ser Lys Val Ser Thr Leu Ser Asp Gly Lys Glu 
385                 390                 395                 400 


Ile Ala Arg Gly Asn Thr Glu Ile Ser Val Leu Lys Glu Gln Met Asn 
                405                 410                 415     


Lys Ile Thr Lys Ala Asn Ser Leu Lys Arg Leu Glu His Lys Leu Arg 
            420                 425                 430         


Leu Ala Phe Gly Phe Ile Tyr Thr Glu Tyr Gly Ser Tyr Lys Ala Phe 
        435                 440                 445             


Val Ser Arg Phe Asn Glu Asp Thr Lys Arg Lys Lys Ile Lys Asn Val 
    450                 455                 460                 


Glu Phe Glu Lys Ile Gly Val Glu Lys Gln Lys Glu Tyr Tyr Glu Ser 
465                 470                 475                 480 


Thr Phe Thr Ser Asn Asn Lys Asp Lys Leu Gly Glu Leu Ile Gln Glu 
                485                 490                 495     


Tyr Glu Lys Leu Ser Leu Asn Asp Leu Ile Glu Asn Asp Thr Phe Leu 
            500                 505                 510         


Lys Val Ile Leu Leu Leu Phe Ile Phe Met Pro Lys Glu Val Lys Gly 
        515                 520                 525             


Asp Phe Leu Gly Phe Ile Lys Lys Tyr Tyr His Asp Thr Lys His Ile 
    530                 535                 540                 


Glu Glu Asp Thr Lys Glu Lys Asp Glu Gly Phe Thr Asn Thr Leu Pro 
545                 550                 555                 560 


Ile Gly Leu Lys Leu Lys Ile Val Glu Arg Asn Ile Ala Lys Leu Ser 
                565                 570                 575     


Val Leu Lys His Ser Leu Ser Leu Lys Val Lys Tyr Asn Arg Gly Gln 
            580                 585                 590         


Tyr Glu Glu Asp Asn Thr Tyr Arg Lys Val Phe Lys Lys Leu Asn Ile 
        595                 600                 605             


Ser His Asn Gln Glu Glu Phe His Lys Ser Met Phe Ser Pro Leu Leu 
    610                 615                 620                 


Arg Tyr Tyr Ala Ser Leu Tyr Lys Leu Ile Asn Asp Phe Glu Ile Tyr 
625                 630                 635                 640 


Thr Leu Ser His Tyr Ile Thr Asp Lys Tyr Ser Thr Leu Asn Lys Val 
                645                 650                 655     


Ile Ala Ser Glu Gln Phe His Tyr Arg Tyr Gly Trp Asn Arg Glu Glu 
            660                 665                 670         


Lys Lys Gly Glu Leu Val Lys Thr Asp Asn Tyr Thr Phe Ser Thr Leu 
        675                 680                 685             


Leu Ser Lys Lys Tyr Gly His Lys Asn Ser Gln Glu Ile Ser Glu Met 
    690                 695                 700                 


Arg Asn Lys Ile Ser His Phe Asp Glu Lys Ile Leu Phe Lys Phe Pro 
705                 710                 715                 720 


Leu Glu Glu Val Ser Ser Val Pro Lys Gly Lys Gly Lys Tyr Lys Lys 
                725                 730                 735     


Asp Glu Pro Ile Lys Ser Leu Lys Glu Lys Arg Glu Glu Ile Val Ser 
            740                 745                 750         


Leu Met Glu Lys Gln Thr Asp Met Gln Lys Val Leu Gly Tyr Asp Ala 
        755                 760                 765             


Ile Asn Asp Phe Arg Met Lys Thr Val Gln Phe Gln Thr Lys Leu Lys 
    770                 775                 780                 


Val Tyr Ser Asn Lys Glu Glu Thr Ile Lys Lys Met Ile Val Glu Ala 
785                 790                 795                 800 


Lys Thr Pro Asn Asp Tyr Tyr Asn Ile Tyr Lys Val Lys Gly Val Glu 
                805                 810                 815     


Gly Ile Asn Glu His Leu Leu Asn Val Ile Gly Glu Thr Glu Ala Glu 
            820                 825                 830         


Lys Ser Ile Gln Glu Gln Ile Ala Glu Gly Asn Lys Val Asn Val 
        835                 840                 845         


<210> 259
<211> 779
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 259
Glu Leu Cys Lys Ile Asp Phe Thr Asp Ala Arg Ser Ser Ser Leu Ile 
1               5                   10                  15      


Glu Tyr Phe Lys Phe Ala Ile Asn Asp Asn Leu Lys Asn Asp Arg Gly 
            20                  25                  30          


Tyr Leu Lys Ala Tyr Val Asn Asp Val Glu Gln Ile Arg Ala Asp Leu 
        35                  40                  45              


Lys Lys Val Gly Gly Lys Gln Arg Asn Leu Glu Asp Arg Val Ser Arg 
    50                  55                  60                  


Thr Lys Val Gln Leu Thr Leu Thr Asn His Ile Glu Asp Arg Glu Gly 
65                  70                  75                  80  


Lys Gln Arg Val Ser Arg Thr Glu Arg Glu Leu Ile Val Pro Gln Asn 
                85                  90                  95      


Ile Lys Leu Tyr Ser Gln Ile Val Gly Arg Glu Val Lys Thr Thr Lys 
            100                 105                 110         


Glu Ile Tyr Leu Ile Lys Arg Phe Leu Glu Tyr Arg Ser Asp Leu Leu 
        115                 120                 125             


Phe Tyr Tyr Gly Phe Val Asp Asn Phe Phe Lys Val Glu Gly Asn Lys 
    130                 135                 140                 


Lys Glu Leu Cys Lys Ile Asp Phe Thr Asp Ala Arg Ser Ser Ser Leu 
145                 150                 155                 160 


Ile Glu Tyr Phe Lys Phe Ala Ile Asn Asp Asn Leu Lys Asn Asp Arg 
                165                 170                 175     


Gly Tyr Leu Lys Ala Tyr Val Asn Asp Val Glu Gln Ile Arg Thr Asp 
            180                 185                 190         


Leu Gln Lys Val Lys Thr Ile Phe Ser Lys Leu Arg His Ala Leu Met 
        195                 200                 205             


His Phe Asp Tyr Asp Phe Phe Glu Lys Leu Phe Asn Gly Glu Glu Val 
    210                 215                 220                 


Gly Phe Asp Phe Asp Ile Lys Phe Leu Asn Ile Met Ile Asp Lys Val 
225                 230                 235                 240 


Glu Lys Leu Asn Ile Glu Thr Lys Lys Glu Phe Ile Glu Asp Glu Val 
                245                 250                 255     


Ile Thr Leu Phe Gly Glu Arg Leu Ser Leu Lys Lys Leu Tyr Gly Leu 
            260                 265                 270         


Phe Ser His Ile Ala Ile Asn Arg Val Ala Phe Asn Lys Phe Ile Asn 
        275                 280                 285             


Ser Phe Leu Ile Lys Asp Gly Ile Glu Asn Arg Ala Leu Lys Asp Phe 
    290                 295                 300                 


Phe Asn Asp Glu Lys Gly Ser Gln Ala Tyr Glu Ile Asp Ile His Ser 
305                 310                 315                 320 


Asn Ala Glu Tyr Lys Ala Leu Tyr Val Gln His Lys Lys Leu Val Met 
                325                 330                 335     


Ala Thr Ser Ala Met Ser Asp Gly Asn Glu Ile Ala Lys Lys Asn Gln 
            340                 345                 350         


Glu Ile Ser Glu Leu Lys Glu Lys Met Asn Ala Ile Thr Lys Ala Asn 
        355                 360                 365             


Ser Leu Ala Arg Leu Glu Tyr Lys Leu Arg Leu Ala Phe Gly Phe Ile 
    370                 375                 380                 


Tyr Thr Glu Tyr Gly Asp Tyr Thr Ala Phe Lys Asn Ser Phe Asp Arg 
385                 390                 395                 400 


Asp Val Lys Ser Ala Lys Tyr Lys Glu Leu Ser Val Glu Arg Leu Lys 
                405                 410                 415     


Ala Tyr Tyr Leu Ala Thr Phe Lys Ala Ser Lys Pro Gln Ser His Glu 
            420                 425                 430         


Lys Leu Glu Glu Val Ala Lys Lys Ile Asp Arg Leu Ser Leu Lys Gln 
        435                 440                 445             


Leu Ile Glu Asn Glu Thr Leu Leu Lys Phe Val Leu Leu Leu Phe Thr 
    450                 455                 460                 


Phe Met Pro Gln Glu Leu Lys Gly Glu Phe Leu Gly Phe Ile Lys Lys 
465                 470                 475                 480 


Tyr Tyr His Asp Lys Lys His Ile Glu Gln Asp Thr Lys Glu Lys Glu 
                485                 490                 495     


Glu Glu Arg Glu Gly Leu Ser Thr Gly Leu Lys Leu Lys Val Leu Glu 
            500                 505                 510         


Lys Asn Ile Arg Ser Leu Ser Ile Leu Lys His Ala Leu Ser Phe Gln 
        515                 520                 525             


Val Lys Tyr Asn Lys Lys Asp Lys Asn Phe Tyr Glu Glu Gly Asn Leu 
    530                 535                 540                 


His Gly Lys Phe Tyr Lys Lys Leu Ala Ile Ser His Asn Gln Glu Glu 
545                 550                 555                 560 


Phe Asn Lys Ser Val Tyr Ala Pro Leu Phe Arg Tyr Tyr Val Ala Leu 
                565                 570                 575     


Tyr Lys Leu Ile Asn Asp Phe Glu Ile Tyr Ser Leu Ala Gln His Ile 
            580                 585                 590         


Val Asn Asn Glu Thr Leu Ala Asp Gln Val Gly Lys Ala Gln Phe Arg 
        595                 600                 605             


Gln Arg Gly Tyr Phe Asn Phe Arg Lys Leu Val Asn Cys Thr Tyr Ala 
    610                 615                 620                 


Thr Ala Gln Asn Ser Ser Tyr Asn Val Leu Ile Phe Met Arg Asn Asp 
625                 630                 635                 640 


Ile Ser His Leu Ser Tyr Glu Pro Leu Phe Asn Cys Pro Leu Glu Glu 
                645                 650                 655     


Lys Ala Ser Tyr Lys Gln Lys Ile Arg Gly Arg Glu Lys Ile Ile Ser 
            660                 665                 670         


Val Lys Pro Leu Ser Glu Ser Arg Ala Glu Ile Val Arg Phe Ile Ala 
        675                 680                 685             


Ser Gln Thr Asp Met Lys Lys Leu Leu Gly Tyr Asp Ala Val Asn Asp 
    690                 695                 700                 


Phe Asn Met Lys Met Val Gln Leu Arg Arg Arg Leu Ser Val Tyr Ala 
705                 710                 715                 720 


Asn Lys Gln Glu Thr Ile Glu Lys Met Ile Asn Lys Ala Lys Thr Pro 
                725                 730                 735     


Asn Asp Phe Tyr Asn Leu Tyr Lys Leu Lys Gly Ile Glu Cys Ile Asn 
            740                 745                 750         


Gln His Leu Leu Lys Val Ile Gly Val Thr Glu Ala Glu Lys Arg Ile 
        755                 760                 765             


Glu Lys Gln Ile Glu Glu Gly Asn Glu Lys Tyr 
    770                 775                 


<210> 260
<211> 840
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 260
Met Leu Lys His Lys Arg Lys Asn Lys Asn Ser Leu Ala Arg Val Val 
1               5                   10                  15      


Leu Ser Asn Tyr Asp Ser Asn Asn Ile Tyr Glu Ile Lys Ile Lys Tyr 
            20                  25                  30          


Glu Lys Leu Ala Lys Leu Asp Lys Ile Asn Ile Ile Glu Met Asp Tyr 
        35                  40                  45              


Asp Ala Asp Asn Asn Val Met Phe Lys Lys Val Leu Phe Asn Asn Lys 
    50                  55                  60                  


Glu Ile Asp Leu Ser His Lys Asp Lys Thr Lys Ile Asn Ile Glu Leu 
65                  70                  75                  80  


Asp Asn Lys Lys Tyr Asn Ile Ser Ala Lys Lys Gln Ile Gly Lys Thr 
                85                  90                  95      


His Leu Val Val Arg Asn Lys Gln Thr Ser Lys Ile Ser Arg Ile Lys 
            100                 105                 110         


Lys Ile Gln Asp Thr Tyr Tyr Arg Gly Lys Asp Val Phe Ile Leu Asp 
        115                 120                 125             


Asn Asn Ile Glu Ile Leu Asp Lys Lys Gln Thr Lys Asp Lys Phe Ile 
    130                 135                 140                 


Val Thr Leu Asn Asp Ile Thr Asn Asn Lys Thr Thr Ser Thr Glu Ala 
145                 150                 155                 160 


Glu Leu Ile Asp Asp Thr Lys Asp Ile Phe Lys Lys Ile Ser Ala Lys 
                165                 170                 175     


Lys Asp Leu Lys Ser Ser Asp Ile Tyr Lys Ile Lys Arg Phe Ile Ser 
            180                 185                 190         


Ile Arg Ser Asn Phe Ser Phe Tyr Tyr Thr Phe Val Asp Asn Tyr Phe 
        195                 200                 205             


Lys Ile Phe His Ala Lys Lys Asp Lys Asn Lys Glu Glu Leu Tyr Lys 
    210                 215                 220                 


Ile Lys Phe Lys Asp Glu Ile Asn Ile Lys Pro Tyr Leu Glu Asn Ile 
225                 230                 235                 240 


Leu Asp Asn Met Lys Asn Lys Asn Gly Ile Leu Tyr Asn Tyr Ala Asn 
                245                 250                 255     


Asp Arg Lys Lys Val Leu Asn Asp Leu Arg Asn Ile Gln Tyr Val Phe 
            260                 265                 270         


Lys Glu Phe Arg His Lys Leu Ala His Phe Asp Tyr Asn Phe Leu Asp 
        275                 280                 285             


Asn Phe Phe Ser Asn Ser Val Glu Glu Lys Tyr Lys Gln Lys Val Asn 
    290                 295                 300                 


Glu Ile Lys Leu Leu Asp Ile Leu Leu Asp Asn Ile Asp Ser Leu Asn 
305                 310                 315                 320 


Val Val Pro Lys Gln Asn Tyr Ile Glu Asp Glu Thr Ile Ser Val Phe 
                325                 330                 335     


Asp Ala Lys Asp Ile Lys Leu Lys Arg Leu Tyr Thr Tyr Tyr Ile Lys 
            340                 345                 350         


Leu Thr Ile Asn Tyr Pro Gly Phe Lys Lys Leu Ile Asn Ser Phe Phe 
        355                 360                 365             


Ile Gln Asp Gly Ile Glu Asn Gln Glu Leu Lys Glu Tyr Ile Asn Asn 
    370                 375                 380                 


Lys Glu Lys Asp Thr Gln Val Leu Lys Glu Leu Asp Asn Lys Ala Tyr 
385                 390                 395                 400 


Tyr Met Asp Ile Ser Gln Tyr Arg Lys Tyr Lys Asn Ile Tyr Asn Lys 
                405                 410                 415     


His Lys Glu Leu Val Ser Glu Lys Glu Leu Ser Ser Asp Gly Lys Lys 
            420                 425                 430         


Ile Asn Ser Leu Asn Gln Lys Ile Asn Lys Leu Lys Ile Asp Met Lys 
        435                 440                 445             


Asn Ile Thr Lys Pro Asn Ala Leu Asn Arg Leu Ile Tyr Arg Leu Arg 
    450                 455                 460                 


Val Ala Phe Gly Phe Ile Tyr Lys Glu Tyr Ala Thr Ile Asn Asn Phe 
465                 470                 475                 480 


Asn Lys Ser Phe Leu Gln Asp Thr Lys Thr Lys Arg Phe Glu Asn Ile 
                485                 490                 495     


Ser Gln Gln Asp Ile Lys Ser Tyr Leu Asp Ile Ser Tyr Gln Asp Lys 
            500                 505                 510         


Gly Lys Phe Phe Val Lys Ser Lys Lys Thr Phe Lys Asn Lys Thr Thr 
        515                 520                 525             


Val Lys Tyr Thr Phe Glu Asp Leu Asp Leu Thr Leu Asn Glu Ile Ile 
    530                 535                 540                 


Thr Gln Asp Asp Ile Phe Val Lys Val Ile Phe Leu Phe Ser Ile Phe 
545                 550                 555                 560 


Met Pro Lys Glu Leu Asn Gly Asp Phe Phe Gly Phe Ile Asn Met Tyr 
                565                 570                 575     


Tyr His Lys Met Lys Asn Ile Ser Tyr Asp Thr Lys Asp Ile Asp Met 
            580                 585                 590         


Leu Asp Thr Ile Ser Gln Asn Met Lys Leu Lys Ile Leu Glu Gln Asn 
        595                 600                 605             


Ile Lys Lys Thr Tyr Val Phe Lys Tyr Tyr Leu Asp Leu Asp Ser Ser 
    610                 615                 620                 


Ile Tyr Ser Lys Leu Val Gln Asn Ile Lys Ile Thr Glu Asp Ile Asp 
625                 630                 635                 640 


Ser Lys Lys Tyr Leu Tyr Ala Lys Ile Phe Lys Tyr Tyr Gln His Leu 
                645                 650                 655     


Tyr Lys Leu Ile Ser Asp Val Glu Ile Tyr Leu Leu Tyr Lys Tyr Asn 
            660                 665                 670         


Ser Lys Glu Asn Leu Ser Ile Thr Ile Asp Lys Asp Glu Leu Lys His 
        675                 680                 685             


Arg Gly Tyr Tyr Asn Phe Gln Ser Leu Leu Ile Lys Asn Asn Ile Asn 
    690                 695                 700                 


Lys Asp Asp Ala Tyr Trp Ser Ile Val Asn Met Arg Asn Asn Leu Ser 
705                 710                 715                 720 


His Gln Asn Ile Asp Glu Leu Val Gly His Phe Cys Lys Gly Cys Leu 
                725                 730                 735     


Arg Lys Ser Thr Thr Asp Ile Ala Glu Leu Trp Leu Arg Lys Asp Ile 
            740                 745                 750         


Leu Thr Ile Thr Asn Glu Ile Ile Asn Lys Ile Glu Ser Phe Lys Asp 
        755                 760                 765             


Ile Lys Ile Thr Leu Gly Tyr Asp Cys Val Asn Asp Phe Thr Gln Lys 
    770                 775                 780                 


Val Lys Gln Tyr Lys Gln Lys Leu Lys Ala Ser Asn Glu Arg Leu Ala 
785                 790                 795                 800 


Lys Lys Ile Glu Glu Lys Gln Asn Gln Val Val Asp Glu Lys Asn Lys 
                805                 810                 815     


Glu Glu Leu Glu Lys Asn Ile Leu Asn Met Lys Asn Ile Gln Lys Ile 
            820                 825                 830         


Asn Arg Tyr Ile Leu Asp Ile Leu 
        835                 840 


<210> 261
<211> 840
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 261
Met Leu Lys His Lys Arg Lys Asn Lys Asn Ser Leu Ala Arg Val Val 
1               5                   10                  15      


Leu Ser Asn Tyr Asp Ser Asn Asn Ile Tyr Glu Ile Lys Ile Lys Tyr 
            20                  25                  30          


Glu Lys Leu Ala Lys Leu Asp Lys Ile Asn Ile Ile Glu Met Asp Tyr 
        35                  40                  45              


Asp Ala Asp Asn Asn Val Met Phe Lys Lys Val Leu Phe Asn Asn Lys 
    50                  55                  60                  


Glu Ile Asp Leu Ser His Lys Asp Lys Thr Lys Ile Asn Ile Glu Leu 
65                  70                  75                  80  


Asp Asn Lys Lys Tyr Asn Ile Ser Ala Lys Lys Gln Ile Gly Lys Thr 
                85                  90                  95      


His Leu Val Val Arg Asp Lys Gln Thr Ser Lys Ile Ser Arg Ile Lys 
            100                 105                 110         


Lys Ile Gln Asp Thr Tyr Tyr Arg Gly Lys Asp Val Phe Ile Leu Asp 
        115                 120                 125             


Asn Asn Ile Glu Ile Leu Asp Lys Lys Gln Thr Lys Asp Lys Phe Ile 
    130                 135                 140                 


Val Thr Leu Asn Asp Ile Thr Asn Asp Lys Thr Thr Ser Thr Glu Ala 
145                 150                 155                 160 


Glu Leu Ile Asp Asp Thr Lys Asp Ile Phe Lys Lys Ile Ser Ala Lys 
                165                 170                 175     


Lys Asp Leu Lys Ser Ser Asp Ile Tyr Lys Ile Lys Arg Phe Ile Ser 
            180                 185                 190         


Ile Arg Ser Asn Phe Ser Phe Tyr Tyr Thr Phe Val Asp Asn Tyr Phe 
        195                 200                 205             


Lys Ile Phe His Ala Lys Lys Asp Lys Asn Lys Glu Glu Leu Tyr Lys 
    210                 215                 220                 


Ile Lys Phe Lys Asp Glu Ile Asn Ile Lys Pro Tyr Leu Glu Asn Ile 
225                 230                 235                 240 


Leu Asp Asn Met Lys Asn Lys Asn Gly Ile Leu Tyr Asp Tyr Ala Asp 
                245                 250                 255     


Asp Arg Glu Lys Val Leu Asn Asp Leu Lys Asn Ile Gln Tyr Val Phe 
            260                 265                 270         


Thr Glu Phe Arg His Lys Leu Ala His Phe Asp Tyr Asn Phe Leu Asp 
        275                 280                 285             


Asn Phe Phe Ser Asn Ser Val Thr Asp Gln Tyr Lys Gln Lys Val Asn 
    290                 295                 300                 


Glu Ile Lys Leu Leu Asp Ile Leu Leu Asp Asn Ile Asp Ser Leu Asn 
305                 310                 315                 320 


Val Val Pro Lys Gln Asn Tyr Ile Glu Asp Glu Thr Ile Ser Val Phe 
                325                 330                 335     


Asp Ala Lys Asp Ile Lys Leu Lys Arg Leu Tyr Thr Tyr Tyr Ile Lys 
            340                 345                 350         


Leu Thr Ile Asn Tyr Pro Gly Phe Lys Lys Leu Ile Asn Ser Phe Phe 
        355                 360                 365             


Ile Gln Asp Gly Ile Glu Asn Gln Glu Leu Lys Glu Tyr Ile Asn Asn 
    370                 375                 380                 


Lys Glu Lys Asp Thr Gln Val Leu Lys Glu Leu Asp Asn Lys Ala Tyr 
385                 390                 395                 400 


Tyr Met Asp Ile Ser Gln Tyr Arg Lys Tyr Lys Asn Ile Tyr Asn Lys 
                405                 410                 415     


His Lys Glu Leu Val Ser Glu Lys Glu Leu Ser Ser Asp Gly Gln Lys 
            420                 425                 430         


Ile Asn Ser Leu Asn Gln Lys Ile Asn Lys Leu Lys Ile Glu Met Lys 
        435                 440                 445             


Asn Ile Thr Lys Pro Asn Ala Leu Asn Arg Leu Ile Tyr Arg Leu Arg 
    450                 455                 460                 


Val Ala Phe Gly Phe Ile Tyr Lys Glu Tyr Ala Thr Ile Asn Asn Phe 
465                 470                 475                 480 


Asn Lys Ser Phe Leu Gln Asp Thr Lys Ile Lys Arg Phe Glu Asn Ile 
                485                 490                 495     


Ser Gln Gln Asp Ile Lys Asn Tyr Leu Asp Ile Ser Tyr Gln Asp Lys 
            500                 505                 510         


Gly Lys Phe Phe Val Lys Ser Lys Lys Thr Phe Lys Asn Lys Thr Thr 
        515                 520                 525             


Ile Lys Tyr Thr Phe Glu Asp Leu Asp Leu Thr Leu Asn Glu Ile Ile 
    530                 535                 540                 


Thr Gln Asp Asp Ile Phe Val Lys Val Ile Phe Leu Phe Ser Ile Phe 
545                 550                 555                 560 


Met Pro Lys Glu Leu Asn Gly Asp Phe Phe Gly Phe Ile Asn Met Tyr 
                565                 570                 575     


Tyr His Lys Met Lys Asn Ile Ser Tyr Asp Thr Lys Asp Ile Asp Met 
            580                 585                 590         


Leu Asp Thr Ile Ser Gln Asn Met Lys Leu Lys Ile Leu Glu Gln Asn 
        595                 600                 605             


Ile Lys Lys Thr Tyr Val Phe Lys Tyr Tyr Leu Asp Leu Asp Ser Ser 
    610                 615                 620                 


Ile Tyr Ser Lys Leu Val Gln Asn Ile Lys Ile Thr Glu Asp Ile Asp 
625                 630                 635                 640 


Ser Lys Lys Tyr Leu Tyr Ala Lys Ile Phe Lys Tyr Tyr Gln His Leu 
                645                 650                 655     


Tyr Lys Leu Ile Ser Asp Val Glu Ile Tyr Leu Leu Tyr Lys Tyr Asn 
            660                 665                 670         


Ser Lys Glu Asn Leu Ser Ile Thr Ile Asp Lys Asp Glu Leu Lys His 
        675                 680                 685             


Arg Gly Tyr Tyr Asn Phe Gln Ser Leu Leu Ile Lys Asn Asn Ile Asn 
    690                 695                 700                 


Lys Asp Asp Ala Tyr Trp Ser Ile Val Asn Met Arg Asn Asn Leu Ser 
705                 710                 715                 720 


His Gln Asn Ile Asp Glu Leu Val Gly His Phe Cys Lys Gly Cys Leu 
                725                 730                 735     


Arg Lys Ser Thr Thr Asp Ile Ala Glu Leu Trp Leu Arg Lys Asp Ile 
            740                 745                 750         


Leu Thr Ile Thr Asn Glu Ile Ile Asn Lys Ile Glu Ser Phe Lys Asp 
        755                 760                 765             


Ile Lys Ile Thr Leu Gly Tyr Asp Cys Val Asn Asp Phe Thr Gln Lys 
    770                 775                 780                 


Val Lys Gln Tyr Lys Gln Lys Leu Lys Ala Ser Asn Glu Arg Leu Ala 
785                 790                 795                 800 


Lys Lys Ile Glu Glu Lys Gln Asn Gln Val Val Asp Glu Lys Asn Lys 
                805                 810                 815     


Glu Glu Leu Glu Lys Lys Ile Leu Asn Met Lys Asn Ile Gln Lys Ile 
            820                 825                 830         


Asn Arg Tyr Ile Leu Asp Ile Leu 
        835                 840 


<210> 262
<211> 589
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas13c sequence

<400> 262
Ile Gln Lys Phe Phe Asp Asn Gly Leu Asp Ala Thr Lys Tyr Asp Ile 
1               5                   10                  15      


Ser Thr Ile Ser Leu Leu Lys Thr Leu Leu Glu Lys Thr Glu Glu Lys 
            20                  25                  30          


Ile Tyr His Glu Lys Asn Asn Tyr Ile Glu Asp Thr Asp Thr Leu Ser 
        35                  40                  45              


Ile Phe Asp Glu Lys Glu Ile Gly Phe Ser Lys Leu His Asn Phe Tyr 
    50                  55                  60                  


Thr Lys Ile Ser Gln Lys Lys Pro Ala Phe Asn Lys Leu Ile Asn Ser 
65                  70                  75                  80  


Phe Leu Ser Lys Asp Gly Val Pro Asn Glu Pro Phe Lys Ala Tyr Leu 
                85                  90                  95      


His Gly Lys Gly Tyr Asp Tyr Phe Glu Asp Ile His Ala Asp Lys Ser 
            100                 105                 110         


Tyr Lys Ala Ile Tyr Val Gln His Lys Leu Leu Val Ala Gln Lys Gln 
        115                 120                 125             


Lys Glu Glu Ala Glu Glu Lys Pro Asp Gly Tyr Lys Leu Lys Ala Tyr 
    130                 135                 140                 


Asn Asp Lys Leu Gln Glu Leu Lys Ile Gln Met Glu Ser Ile Thr Lys 
145                 150                 155                 160 


Ala Asn Ser Leu Lys Arg Leu Glu Val Lys Met Arg Leu Ala Phe Gly 
                165                 170                 175     


Phe Ile Thr Asn Glu Tyr Lys Tyr Asp Phe Lys Lys Phe Asn Ala Glu 
            180                 185                 190         


Phe Thr Leu Asp Val Lys Thr Lys Glu Lys Leu Asp Arg Phe Lys Ala 
        195                 200                 205             


Thr Ser Asp Glu Arg Leu Gln His Tyr Phe Glu Ser Thr Phe Glu Glu 
    210                 215                 220                 


Lys Thr Phe Phe His Phe Thr Val Ser Ser Tyr Asp Lys Lys Gln Lys 
225                 230                 235                 240 


Lys Ser Val Glu Lys Val Lys Thr Ile Phe Asn Leu Val Glu Asn Glu 
                245                 250                 255     


Thr Leu Gln Thr Leu Val Gln Asp Ser Pro Leu Leu Gln Ile Ile Thr 
            260                 265                 270         


Leu Leu Tyr Leu Phe Ile Pro Lys Glu Leu Gln Gly Asp Phe Ile Gly 
        275                 280                 285             


Phe Ile Leu Arg Ile Tyr His Gln Ile Lys Asn Ile Thr Ser Asp Thr 
    290                 295                 300                 


Lys Glu Asp Glu Ile Ser Ile Glu Glu Ser Gln Asn Ser Phe Ala Leu 
305                 310                 315                 320 


Lys Leu Lys Val Leu Ala Lys Ser Leu Arg Gly Leu Gln Leu Phe Asn 
                325                 330                 335     


Tyr Ser Leu Ser His Glu Thr Leu Tyr Asn Lys Asn Glu His Phe Phe 
            340                 345                 350         


Tyr Glu Lys Gly Asn Arg Trp Lys Asn Ile Tyr Lys Ala Leu Gly Ile 
        355                 360                 365             


Ser His Asn Thr Glu Glu Phe Asp Ile His Leu Val Ala Pro Ile Ile 
    370                 375                 380                 


Lys Tyr His Ile Asn Leu Tyr Lys Leu Ile Gly Asp Phe Glu Ile Tyr 
385                 390                 395                 400 


Ala Leu Leu Thr Phe Ala Lys Lys Ser Arg Ser His Glu Thr Leu Ser 
                405                 410                 415     


Val Ile Ser Lys Ser Asp Ala Leu Lys Phe Lys Glu Asn Tyr Asn Phe 
            420                 425                 430         


Ser Thr Leu Leu Ser Lys Ala Phe Arg Ile Asp Val Asn Asn Lys Asn 
        435                 440                 445             


Asn Pro Pro Tyr Ile Gln Thr Leu Lys Gln Ile Arg Asn Asn Ile Ser 
    450                 455                 460                 


His Gln Asn Ile Glu Lys Met Met Thr Ala Phe Glu Gln Asn Asp Ile 
465                 470                 475                 480 


Ser Lys Gln Arg Lys Glu Ile Ile Ile Tyr Leu Gln Thr Asp His Gln 
                485                 490                 495     


Glu Met Gln Lys Leu Leu His Tyr Asn Pro Val Asn Asp Phe Thr Met 
            500                 505                 510         


Lys Thr Val Gln Tyr Arg Ile Met Leu Asp Lys Tyr Lys Thr Gly Met 
        515                 520                 525             


Ala Asp Asn Asp Glu Arg Ile Glu Asn Arg Ala Asp Leu Ile Ile Lys 
    530                 535                 540                 


Gln Leu Lys Lys Glu Thr Pro Asn Asp Tyr Tyr Leu Ile Tyr Lys Leu 
545                 550                 555                 560 


Lys Ala Ile Glu Leu Leu Lys Gln Lys Met Ile Glu Ala Ile Gly Glu 
                565                 570                 575     


Thr Glu Gln Glu Lys Lys Ile Arg Lys Ala Ile Ala Lys 
            580                 585                 


<210> 263
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 263
auugcuccuu acgaggagac gagcuggugg cguaggc                                37


<210> 264
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 264
auugcuccuu acgaggagac gagcugaugg cguaggc                                37


<210> 265
<211> 53
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 265
cuuucaagac uaauagauug cuccuuacga ggagacgagc ugguggcgua ggc              53


<210> 266
<211> 53
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 266
cuuucaagac uaauagauug cuccuuacga ggagacgagc ugauggcgua ggc              53


<210> 267
<211> 53
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 267
cuuucaagac uaauagauug cuccuuacga ggagacccua cgccaucagc ucc              53


<210> 268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 268
gtagttggag ctggtggcgt                                                   20


<210> 269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 269
gtagttggag ctgatggcgt                                                   20


<210> 270
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 270
gttagaatat aaccctgttt gtaggggtaa taaaac                                 36


<210> 271
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 271
ttgactacac tctctatctc ttagggagac tgaaac                                 36


<210> 272
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 272
actagactat acccccattt gagaggggac taaaac                                 36


<210> 273
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 273
ccagctccaa ctaccacaag tttat                                             25


<210> 274
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 274
accagctcca actaccacaa gttta                                             25


<210> 275
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 275
caccagctcc aactaccaca agttt                                             25


<210> 276
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 276
ccaccagctc caactaccac aagtt                                             25


<210> 277
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 277
gccaccagct ccaactacca caagt                                             25


<210> 278
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 278
cgccaccagc tccaactacc acaag                                             25


<210> 279
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 279
acgccaccag ctccaactac cacaa                                             25


<210> 280
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 280
tacgccacca gctccaacta ccaca                                             25


<210> 281
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 281
ctacgccacc agctccaact accac                                             25


<210> 282
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 282
cctacgccac cagctccaac tacca                                             25


<210> 283
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 283
gcctacgcca ccagctccaa ctacc                                             25


<210> 284
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 284
tgcctacgcc accagctcca actac                                             25


<210> 285
<211> 53
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 285
cuuucaagac uaauagauug cuccuuacga ggagacgagc ugguggcgua ggc              53


