                         SEQUENCE LISTING

<110>  INTEGRATED DNA TECHNOLOGIES, INC.
       Dobosy, Joseph
       Perschbacher, Katherine
       Beltz, Kristin
       Rose, Scott
       Behlke, Mark A.
 
<120>  RNASE H2 MUTANTS THAT REDUCE PRIMER DIMERS AND OFF-TARGET 
       AMPLIFICATION IN RHPCR-BASED AMPLICON SEQUENCING WITH 
       HIGH-FIDELITY DNA POLYMERASES

<130>  IDT01-018-PCT

<140>  PCT/US21/64879
<141>  2021-12-22

<150>  US63/277273
<151>  2021-11-09

<150>  US63/130548
<151>  2020-12-24

<160>  101   

<170>  PatentIn version 3.5

<210>  1
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  1

Met Lys Val Ala Gly Ala Asp Glu Ala Gly Arg Gly Pro Val Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Glu Glu Asp Lys Ile Arg Ser 
            20                  25                  30          


Leu Thr Lys Leu Gly Val Lys Asp Ser Lys Gln Leu Thr Pro Ala Gln 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Glu Val Ile Tyr Ile Asp Ser Ala Asp Val Lys Ala Glu 
            100                 105                 110         


Arg Phe Ala Glu Asn Ile Arg Ser Arg Leu Ala Tyr Glu Ala Lys Val 
        115                 120                 125             


Val Ala Glu His Lys Ala Asp Ala Lys Tyr Glu Ile Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Lys Lys Trp Leu Glu Glu Trp Tyr Ser Lys His Gly Asn Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Arg Thr Trp Asp Thr Ala Lys Lys Ile Glu Glu Lys Phe 
        195                 200                 205             


Lys Arg Ala Gln Leu Thr Leu Asp Asn Phe Leu Lys Arg Phe Arg Asn 
    210                 215                 220                 


Lys Leu Ala Ala Ala Leu Glu Ile Lys Arg Ala Ser Gln Pro Glu Leu 
225                 230                 235                 240 


Ala Pro Glu Asp Pro Glu Asp Val Glu His His His His His His 
                245                 250                 255 


<210>  2
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  2

Met Lys Val Ala Gly Ala Asp Glu Ala Gly Arg Gly Pro Val Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Lys Arg 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Ala Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Glu Val 
        115                 120                 125             


Val Ala Lys His Lys Ala Asp Asp Ile Phe Pro Val Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Lys Lys Trp Leu Glu Glu Trp Tyr Ser Lys His Gly Asn Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Arg Thr Trp Asp Thr Ala Lys Lys Ile Glu Glu Lys Phe 
        195                 200                 205             


Lys Arg Ala Gln Leu Thr Leu Asp Lys Phe Phe Lys Lys Pro Lys Leu 
    210                 215                 220                 


Ala Ala Ala Leu Glu Ile Lys Arg Ala Ser Gln Pro Glu Leu Ala Pro 
225                 230                 235                 240 


Glu Asp Pro Glu Asp Val Glu His His His His His His 
                245                 250             


<210>  3
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  3

Met Lys Val Ala Gly Ile Asp Glu Ala Gly Arg Gly Pro Ala Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Ala Gln 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Ala Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Lys Val 
        115                 120                 125             


Val Ala Glu His Lys Ala Asp Ala Lys Tyr Glu Ile Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Arg Ala Phe Leu Glu Asn Tyr Tyr Arg Glu His Gly Glu Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Lys Gly Trp Lys Thr Leu Lys Lys Ile Ala Glu Lys Val 
        195                 200                 205             


Glu Ser Glu Lys Lys Ala Glu Glu Arg Gln Ala Thr Leu Asp Arg Tyr 
    210                 215                 220                 


Phe Arg Lys Val Lys Leu Ala Ala Ala Leu Glu Ile Lys Arg Ala Ser 
225                 230                 235                 240 


Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Val Glu His His His 
                245                 250                 255     


His His His 
            


<210>  4
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  4
ggtgcagatg aagctggtcg tggttctgtt attggtccgc tggttattgt tgct             54


<210>  5
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  5
agcaacaata accagcggac caataacaga accacgacca gcttcatctg cacc             54


<210>  6
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  6
aagccggatg ttatttacgc tgatgccgta gatgttgatg aagaacgttt cgctaga          57


<210>  7
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  7
tctagcgaaa cgttcttcat caacatctac ggcatcagcg taaataacat ccggctt          57


<210>  8
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  8
ggtatagatg aagctggtcg tggttctgct attggtccgc tggttattgt tgct             54


<210>  9
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  9
agcaacaata accagcggac caatagcaga accacgacca gcttcatcta tacc             54


<210>  10
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  10
agactccaaa aagctgaccc cggcgcgccg tgaaaaactg ttcgatgaaa tcg              53


<210>  11
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  11
cgatttcatc gaacagtttt tcacggcgcg ccggggtcag ctttttggag tct              53


<210>  12
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  12
aagccggatg ttatttacgc tgatgccgta gatgttgatg aagaacgttt cgctaga          57


<210>  13
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  13
tctagcgaaa cgttcttcat caacatctac ggcatcagcg taaataacat ccggctt          57


<210>  14
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  14

Met Lys Val Ala Gly Ala Asp Glu Ala Gly Arg Gly Ser Val Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Lys Arg 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Ala Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Glu Val 
        115                 120                 125             


Val Ala Lys His Lys Ala Asp Asp Ile Phe Pro Val Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Lys Lys Trp Leu Glu Glu Trp Tyr Ser Lys His Gly Asn Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Arg Thr Trp Asp Thr Ala Lys Lys Ile Glu Glu Lys Phe 
        195                 200                 205             


Lys Arg Ala Gln Leu Thr Leu Asp Lys Phe Phe Lys Lys Pro Lys Leu 
    210                 215                 220                 


Ala Ala Ala Leu Glu Ile Lys Arg Ala Ser Gln Pro Glu Leu Ala Pro 
225                 230                 235                 240 


Glu Asp Pro Glu Asp Val Glu His His His His His His 
                245                 250             


<210>  15
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  15

Met Lys Val Ala Gly Ala Asp Glu Ala Gly Arg Gly Pro Val Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Lys Arg 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Val Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Glu Val 
        115                 120                 125             


Val Ala Lys His Lys Ala Asp Asp Ile Phe Pro Val Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Lys Lys Trp Leu Glu Glu Trp Tyr Ser Lys His Gly Asn Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Arg Thr Trp Asp Thr Ala Lys Lys Ile Glu Glu Lys Phe 
        195                 200                 205             


Lys Arg Ala Gln Leu Thr Leu Asp Lys Phe Phe Lys Lys Pro Lys Leu 
    210                 215                 220                 


Ala Ala Ala Leu Glu Ile Lys Arg Ala Ser Gln Pro Glu Leu Ala Pro 
225                 230                 235                 240 


Glu Asp Pro Glu Asp Val Glu His His His His His His 
                245                 250             


<210>  16
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  16

Met Lys Val Ala Gly Ala Asp Glu Ala Gly Arg Gly Ser Val Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Lys Arg 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Val Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Glu Val 
        115                 120                 125             


Val Ala Lys His Lys Ala Asp Asp Ile Phe Pro Val Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Lys Lys Trp Leu Glu Glu Trp Tyr Ser Lys His Gly Asn Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Arg Thr Trp Asp Thr Ala Lys Lys Ile Glu Glu Lys Phe 
        195                 200                 205             


Lys Arg Ala Gln Leu Thr Leu Asp Lys Phe Phe Lys Lys Pro Lys Leu 
    210                 215                 220                 


Ala Ala Ala Leu Glu Ile Lys Arg Ala Ser Gln Pro Glu Leu Ala Pro 
225                 230                 235                 240 


Glu Asp Pro Glu Asp Val Glu His His His His His His 
                245                 250             


<210>  17
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  17

Met Lys Val Ala Gly Ile Asp Glu Ala Gly Arg Gly Ser Ala Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Ala Gln 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Ala Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Lys Val 
        115                 120                 125             


Val Ala Glu His Lys Ala Asp Ala Lys Tyr Glu Ile Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Arg Ala Phe Leu Glu Asn Tyr Tyr Arg Glu His Gly Glu Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Lys Gly Trp Lys Thr Leu Lys Lys Ile Ala Glu Lys Val 
        195                 200                 205             


Glu Ser Glu Lys Lys Ala Glu Glu Arg Gln Ala Thr Leu Asp Arg Tyr 
    210                 215                 220                 


Phe Arg Lys Val Lys Leu Ala Ala Ala Leu Glu Ile Lys Arg Ala Ser 
225                 230                 235                 240 


Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Val Glu His His His 
                245                 250                 255     


His His His 
            


<210>  18
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  18

Met Lys Val Ala Gly Ile Asp Glu Ala Gly Arg Gly Pro Ala Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Ala Arg 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Ala Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Lys Val 
        115                 120                 125             


Val Ala Glu His Lys Ala Asp Ala Lys Tyr Glu Ile Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Arg Ala Phe Leu Glu Asn Tyr Tyr Arg Glu His Gly Glu Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Lys Gly Trp Lys Thr Leu Lys Lys Ile Ala Glu Lys Val 
        195                 200                 205             


Glu Ser Glu Lys Lys Ala Glu Glu Arg Gln Ala Thr Leu Asp Arg Tyr 
    210                 215                 220                 


Phe Arg Lys Val Lys Leu Ala Ala Ala Leu Glu Ile Lys Arg Ala Ser 
225                 230                 235                 240 


Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Val Glu His His His 
                245                 250                 255     


His His His 
            


<210>  19
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  19

Met Lys Val Ala Gly Ile Asp Glu Ala Gly Arg Gly Pro Ala Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Ala Gln 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Val Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Lys Val 
        115                 120                 125             


Val Ala Glu His Lys Ala Asp Ala Lys Tyr Glu Ile Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Arg Ala Phe Leu Glu Asn Tyr Tyr Arg Glu His Gly Glu Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Lys Gly Trp Lys Thr Leu Lys Lys Ile Ala Glu Lys Val 
        195                 200                 205             


Glu Ser Glu Lys Lys Ala Glu Glu Arg Gln Ala Thr Leu Asp Arg Tyr 
    210                 215                 220                 


Phe Arg Lys Val Lys Leu Ala Ala Ala Leu Glu Ile Lys Arg Ala Ser 
225                 230                 235                 240 


Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Val Glu His His His 
                245                 250                 255     


His His His 
            


<210>  20
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  20

Met Lys Val Ala Gly Ile Asp Glu Ala Gly Arg Gly Ser Ala Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Ala Gln 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Val Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Lys Val 
        115                 120                 125             


Val Ala Glu His Lys Ala Asp Ala Lys Tyr Glu Ile Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Arg Ala Phe Leu Glu Asn Tyr Tyr Arg Glu His Gly Glu Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Lys Gly Trp Lys Thr Leu Lys Lys Ile Ala Glu Lys Val 
        195                 200                 205             


Glu Ser Glu Lys Lys Ala Glu Glu Arg Gln Ala Thr Leu Asp Arg Tyr 
    210                 215                 220                 


Phe Arg Lys Val Lys Leu Ala Ala Ala Leu Glu Ile Lys Arg Ala Ser 
225                 230                 235                 240 


Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Val Glu His His His 
                245                 250                 255     


His His His 
            


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  21
cagcctcatc caaaagagga aa                                                22


<210>  22
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  3'-PROPRIETARY BLOCKER GROUP

<400>  22
cagcctcatc caaaagagga aacaggag                                          28


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  23
ctcactctaa accccagcat t                                                 21


<210>  24
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'- Iowa Black FLUORESCENT QUENCHER

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  3'-(6-FAM) FLUORESCENT LABEL

<400>  24
tataagctac cagcatggtt tttccatgct ggtagcttat a                           41


<210>  25
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  RIBONUCLEOTIDE

<400>  25
tataagctac cagcatggtt tttccatgct ggtagcttat a                           41


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  26
agctctgccc aaagattacc ctg                                               23


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  27
ctgagcttca tgcctttact gt                                                22


<210>  28
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  RIBONCLEOTIDE

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  3'-C3 spacer (propanediol) blocker group

<400>  28
ctgagcttca tgcctttact gtaccccc                                          28


<210>  29
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  3'-C3 spacer (propanediol) blocker group

<400>  29
ctgagcttca tgcctttact gtcccccc                                          28


<210>  30
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  3'-C3 spacer (propanediol) blocker group

<400>  30
ctgagcttca tgcctttact gtgccccc                                          28


<210>  31
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  3'-C3 spacer (propanediol) blocker group

<400>  31
ctgagcttca tgcctttact gtuccccc                                          28


<210>  32
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  32
agctctgccc aaagattacc ctgacagcta agtggcagtg gaagttggcc tcagaagtag       60

tggccagctg tgtgtcgggg aacagtaaag gcatgaagct cag                        103


<210>  33
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  33
agctctgccc aaagattacc ctgacagcta agtggcagtg gaagttggcc tcagaagtag       60

tggccagctg tgtgtcgggg cacagtaaag gcatgaagct cag                        103


<210>  34
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  34
agctctgccc aaagattacc ctgacagcta agtggcagtg gaagttggcc tcagaagtag       60

tggccagctg tgtgtcgggg gacagtaaag gcatgaagct cag                        103


<210>  35
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  35
agctctgccc aaagattacc ctgacagcta agtggcagtg gaagttggcc tcagaagtag       60

tggccagctg tgtgtcgggg tacagtaaag gcatgaagct cag                        103


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  36
gtgattttgg tctagctaca gt                                                22


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  37
cctcaattct taccatccac aaa                                               23


<210>  38
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  3'-C3 spacer (propanediol) blocker group

<400>  38
gtgattttgg tctagctaca gtgaaatg                                          28


<210>  39
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  3'-C3 spacer (propanediol) blocker group

<400>  39
gtgattttgg tctagctaca gagaaatg                                          28


<210>  40
<211>  401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  40
taagaggaaa gatgaagtac tatgttttaa agaatattat attacagaat tatagaaatt       60

agatctctta cctaaactct tcataatgct tgctctgata ggaaaatgag atctactgtt      120

ttcctttact tactacacct cagatatatt tcttcatgaa gacctcacag taaaaatagg      180

tgattttggt ctagctacag tgaaatctcg atggagtggg tcccatcagt ttgaacagtt      240

gtctggatcc attttgtgga tggtaagaat tgaggctatt tttccactga ttaaattttt      300

ggccctgaga tgctgctgag ttactagaaa gtcattgaag gtctcaacta tagtattttc      360

atagttccca gtattcacaa aaatcagtgt tcttattttt t                          401


<210>  41
<211>  401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  41
taagaggaaa gatgaagtac tatgttttaa agaatattat attacagaat tatagaaatt       60

agatctctta cctaaactct tcataatgct tgctctgata ggaaaatgag atctactgtt      120

ttcctttact tactacacct cagatatatt tcttcatgaa gacctcacag taaaaatagg      180

tgattttggt ctagctacag agaaatctcg atggagtggg tcccatcagt ttgaacagtt      240

gtctggatcc attttgtgga tggtaagaat tgaggctatt tttccactga ttaaattttt      300

ggccctgaga tgctgctgag ttactagaaa gtcattgaag gtctcaacta tagtattttc      360

atagttccca gtattcacaa aaatcagtgt tcttattttt t                          401


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  42
ggcagatttt cttctgcacc gcg                                               23


<210>  43
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  INTERNUCLEOTIDE C3 PROPANE DIOL SPACER

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  3'-C3 PROPANE DIOL SPACER

<400>  43
ggcagatttt cttctgcacc gcggttc                                           27


<210>  44
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  44
tcccgtcgag caccagcaat tttactc                                           27


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  45
ctttggataa ggaagaagcc aact                                              24


<210>  46
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  INTERNUCLEOTIDE C2 PROPANE DIOL

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  3'-C2 PROPANE DIOL

<400>  46
ctttggataa ggaagaagcc aacugcag                                          28


<210>  47
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  47
gggagcttga aatgaacaag gtgagaag                                          28


<210>  48
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  48
cagccagccg cagcacgttc gctcatagga gatatggtag agccgc                      46


<210>  49
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  49
gagagaattt gtaccacctc ccaccgggca catagcagtc ctagggacag t                51


<210>  50
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  50
ggcttggctc tgctaacacg tt                                                22


<210>  51
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  51
ggacgtttgt aatgtccgct cc                                                22


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-(6-carboxyfluorescein) MOIETY

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  3'-( Iowa Black FQ fluorescence quencher) MOIETY

<400>  52
acgtgctgcg gctggctggt                                                   20


<210>  53
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  53
ccaaagagta aagtccttct ctctcgagag actgttggcc cttgaagg                    48


<210>  54
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  54
gtgttgatgt tatccacctt ttgtggacta ggaaaacaga tcaatag                     47


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  55
taatcctgga actccggtgc                                                   20


<210>  56
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  56
tttatgccaa ttaacatttt gac                                               23


<210>  57
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-(6-carboxyfluorescein) MOIETY

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  RIBONCLEOTIDE

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  3'-(Iowa Black FQ fluorescence quencher) MOIETY

<400>  57
cctccctgtg gatgagagag aagg                                              24


<210>  58
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  3'-C3 PROPANE DIOL

<400>  58
cagccagccg cagcacgttc gctcatagga gatatggtag agccgcagac ag               52


<210>  59
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  3'-C3 PROPANE DIOL

<400>  59
gagagaattt gtaccacctc ccaccgggca catagcagtc ctagggacag tggcgtt          57


<210>  60
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  3'-C3 PROPANE DIOL

<400>  60
ggcttggctc tgctaacacg ttgctcaa                                          28


<210>  61
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  3'-C3 PROPANE DIOL

<400>  61
ggacgtttgt aatgtccgct ccggcact                                          28


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-(6-carboxyfluorescein) MOIETY

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  3'-(Iowa Black FQ fluorescence quencher) MOIETY

<400>  62
acgtgctgcg gctggctggt                                                   20


<210>  63
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  3'-C3 PROPANE DIOL

<400>  63
ccaaagagta aagtccttct ctctcgagag actgttggcc cttgaaggag agca             54


<210>  64
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  3'-C3 PROPANE DIOL

<400>  64
gtgttgatgt tatccacctt ttgtggacta ggaaaacaga tcaatagata agc              53


<210>  65
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  3'-C3 PROPANE DIOL

<400>  65
taatcctgga actccggtgc uaaggt                                            26


<210>  66
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  3'-C3 PROPANE DIOL

<400>  66
tttatgccaa ttaacatttt gacuttatt                                         29


<210>  67
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-(6-carboxyfluorescein) MOIETY

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  3'-(Iowa Black FQ fluorescence quencher) MOIETY

<400>  67
cctccctgtg gatgagagag aagg                                              24


<210>  68
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  2 C3 PROPANE DIOL INTERNUCLEOTIDE LINKAGES

<400>  68
cagccagccg cagcacgttc gctcatagga gatatggtag agccgcagag                  50


<210>  69
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  2 C3 PROPANE DIOL INTERNUCLEOTIDE LINKAGES

<400>  69
gagagaattt gtaccacctc ccaccgggca catagcagtc ctagggacag tggtt            55


<210>  70
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  2 C3 PROPANE DIOL INTERNUCLEOTIDE LINKAGES

<400>  70
ggcttggctc tgctaacacg ttgcaa                                            26


<210>  71
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  2 C3 PROPANE DIOL INTERNUCLEOTIDE LINKAGES

<400>  71
ggacgtttgt aatgtccgct ccggct                                            26


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-(6-carboxyfluorescein) MOIETY

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  3'-(Iowa Black FQ fluorescence quencher) MOIETY

<400>  72
acgtgctgcg gctggctggt                                                   20


<210>  73
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  2 C3 PROPANE DIOL INTERNUCLEOTIDE LINKAGES

<400>  73
ccaaagagta aagtccttct ctctcgagag actgttggcc cttgaaggag ca               52


<210>  74
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  2 C3 PROPANE DIOL INTERNUCLEOTIDE LINKAGES

<400>  74
gtgttgatgt tatccacctt ttgtggacta ggaaaacaga tcaatagatg c                51


<210>  75
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2 C3 PROPANE DIOL INTERNUCLEOTIDE LINKAGES

<400>  75
taatcctgga actccggtgc uagt                                              24


<210>  76
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  2 C3 PROPANE DIOL INTERNUCLEOTIDE LINKAGES

<400>  76
tttatgccaa ttaacatttt gacuttt                                           27


<210>  77
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-(6-carboxyfluorescein) MOIETY

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  3'-(Iowa Black FQ fluorescence quencher) MOIETY

<400>  77
cctccctgtg gatgagagag aagg                                              24


<210>  78
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  78
atgaaagttg caggtgcaga tgaagctggt cgtggtccag ttattggtcc gctggttatt       60

gttgctgctg ttgtggagga agacaaaatc cgctctctga ctaagctggg tgttaaagac      120

tccaaacagc tgaccccggc gcaacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggaa      300

gttatttaca ttgattccgc tgatgttaaa gctgaacgtt tcgctgaaaa cattcgcagc      360

cgtctggcgt acgaagcgaa agttgtagcc gaacataaag cggatgcgaa gtatgagatc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactaa gaaatggctg      540

gaagaatggt atagcaaaca cggcaatttc ccgccgatcg tgcgtcgtac ttgggatact      600

gcaaagaaaa tcgaagaaaa attcaaacgt gcgcagctga ccctggacaa cttcctgaag      660

cgttttcgca acaagcttgc ggccgcactc gagatcaaac gggctagcca gccagaactc      720

gccccggaag accccgagga tgtcgagcac caccaccacc accactga                   768


<210>  79
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  79
atgaaagttg caggtgcaga tgaagctggt cgtggtccag ttattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccgaa gcgacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgga agttgtagcc aaacataaag cggatgacat ctttccggtc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactaa gaaatggctg      540

gaagaatggt atagcaaaca cggcaatttc ccgccgatcg tgcgtcgtac ttgggatact      600

gcaaagaaaa tcgaagaaaa attcaaacgt gcgcagctga ccctggacaa gttcttcaag      660

aaacctaagc ttgcggccgc actcgagatc aaacgggcta gccagccaga actcgccccg      720

gaagaccccg aggatgtcga gcaccaccac caccaccact ga                         762


<210>  80
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  80
atgaaagttg caggtataga tgaagctggt cgtggtccag ctattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccggc gcaacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgaa agttgtagcc gaacataaag cggatgcgaa gtatgagatc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactag ggcattcctg      540

gaaaattact atagagaaca cggcgaattc ccgccgatcg tgcgtaaagg ttggaagact      600

ctaaagaaaa tcgcagaaaa agtcgaaagt gagaagaagg ctgaggaacg gcaggcgacc      660

ctggacaggt acttcaggaa ggttaagctt gcggccgcac tcgagatcaa acgggctagc      720

cagccagaac tcgccccgga agaccccgag gatgtcgagc accaccacca ccaccactga      780


<210>  81
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  81
atgaaagttg caggtgcaga tgaagctggt cgtggttctg ttattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccgaa gcgacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgga agttgtagcc aaacataaag cggatgacat ctttccggtc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactaa gaaatggctg      540

gaagaatggt atagcaaaca cggcaatttc ccgccgatcg tgcgtcgtac ttgggatact      600

gcaaagaaaa tcgaagaaaa attcaaacgt gcgcagctga ccctggacaa gttcttcaag      660

aaacctaagc ttgcggccgc actcgagatc aaacgggcta gccagccaga actcgccccg      720

gaagaccccg aggatgtcga gcaccaccac caccaccact ga                         762


<210>  82
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  82
atgaaagttg caggtgcaga tgaagctggt cgtggtccag ttattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccgaa gcgacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg tagatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgga agttgtagcc aaacataaag cggatgacat ctttccggtc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactaa gaaatggctg      540

gaagaatggt atagcaaaca cggcaatttc ccgccgatcg tgcgtcgtac ttgggatact      600

gcaaagaaaa tcgaagaaaa attcaaacgt gcgcagctga ccctggacaa gttcttcaag      660

aaacctaagc ttgcggccgc actcgagatc aaacgggcta gccagccaga actcgccccg      720

gaagaccccg aggatgtcga gcaccaccac caccaccact ga                         762


<210>  83
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  83
atgaaagttg caggtgcaga tgaagctggt cgtggttctg ttattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccgaa gcgacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg tagatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgga agttgtagcc aaacataaag cggatgacat ctttccggtc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactaa gaaatggctg      540

gaagaatggt atagcaaaca cggcaatttc ccgccgatcg tgcgtcgtac ttgggatact      600

gcaaagaaaa tcgaagaaaa attcaaacgt gcgcagctga ccctggacaa gttcttcaag      660

aaacctaagc ttgcggccgc actcgagatc aaacgggcta gccagccaga actcgccccg      720

gaagaccccg aggatgtcga gcaccaccac caccaccact ga                         762


<210>  84
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  84
atgaaagttg caggtataga tgaagctggt cgtggttctg ctattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccggc gcaacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgaa agttgtagcc gaacataaag cggatgcgaa gtatgagatc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactag ggcattcctg      540

gaaaattact atagagaaca cggcgaattc ccgccgatcg tgcgtaaagg ttggaagact      600

ctaaagaaaa tcgcagaaaa agtcgaaagt gagaagaagg ctgaggaacg gcaggcgacc      660

ctggacaggt acttcaggaa ggttaagctt gcggccgcac tcgagatcaa acgggctagc      720

cagccagaac tcgccccgga agaccccgag gatgtcgagc accaccacca ccaccactga      780


<210>  85
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  85
atgaaagttg caggtataga tgaagctggt cgtggtccag ctattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccggc gcgccgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgaa agttgtagcc gaacataaag cggatgcgaa gtatgagatc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactag ggcattcctg      540

gaaaattact atagagaaca cggcgaattc ccgccgatcg tgcgtaaagg ttggaagact      600

ctaaagaaaa tcgcagaaaa agtcgaaagt gagaagaagg ctgaggaacg gcaggcgacc      660

ctggacaggt acttcaggaa ggttaagctt gcggccgcac tcgagatcaa acgggctagc      720

cagccagaac tcgccccgga agaccccgag gatgtcgagc accaccacca ccaccactga      780


<210>  86
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  86
atgaaagttg caggtataga tgaagctggt cgtggtccag ctattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccggc gcaacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgt agatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgaa agttgtagcc gaacataaag cggatgcgaa gtatgagatc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactag ggcattcctg      540

gaaaattact atagagaaca cggcgaattc ccgccgatcg tgcgtaaagg ttggaagact      600

ctaaagaaaa tcgcagaaaa agtcgaaagt gagaagaagg ctgaggaacg gcaggcgacc      660

ctggacaggt acttcaggaa ggttaagctt gcggccgcac tcgagatcaa acgggctagc      720

cagccagaac tcgccccgga agaccccgag gatgtcgagc accaccacca ccaccactga      780


<210>  87
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  87
atgaaagttg caggtataga tgaagctggt cgtggttctg ctattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccggc gcaacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgt agatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgaa agttgtagcc gaacataaag cggatgcgaa gtatgagatc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactag ggcattcctg      540

gaaaattact atagagaaca cggcgaattc ccgccgatcg tgcgtaaagg ttggaagact      600

ctaaagaaaa tcgcagaaaa agtcgaaagt gagaagaagg ctgaggaacg gcaggcgacc      660

ctggacaggt acttcaggaa ggttaagctt gcggccgcac tcgagatcaa acgggctagc      720

cagccagaac tcgccccgga agaccccgag gatgtcgagc accaccacca ccaccactga      780


<210>  88
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  88

Met Lys Val Ala Gly Ala Asp Glu Ala Gly Arg Gly Ser Val Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Lys Arg 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Ala Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Glu Val 
        115                 120                 125             


Val Ala Lys His Lys Ala Asp Asp Ile Phe Pro Val Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Lys Lys Trp Leu Glu Glu Trp Tyr Ser Lys His Gly Asn Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Arg Thr Trp Asp Thr Ala Lys Lys Ile Glu Glu Lys Phe 
        195                 200                 205             


Lys Arg Ala Gln Leu Thr Leu Asp Lys Phe Phe Lys Lys Pro 
    210                 215                 220         


<210>  89
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  89

Met Lys Val Ala Gly Ala Asp Glu Ala Gly Arg Gly Pro Val Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Lys Arg 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Val Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Glu Val 
        115                 120                 125             


Val Ala Lys His Lys Ala Asp Asp Ile Phe Pro Val Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Lys Lys Trp Leu Glu Glu Trp Tyr Ser Lys His Gly Asn Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Arg Thr Trp Asp Thr Ala Lys Lys Ile Glu Glu Lys Phe 
        195                 200                 205             


Lys Arg Ala Gln Leu Thr Leu Asp Lys Phe Phe Lys Lys Pro 
    210                 215                 220         


<210>  90
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  90

Met Lys Val Ala Gly Ala Asp Glu Ala Gly Arg Gly Ser Val Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Lys Arg 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Val Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Glu Val 
        115                 120                 125             


Val Ala Lys His Lys Ala Asp Asp Ile Phe Pro Val Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Lys Lys Trp Leu Glu Glu Trp Tyr Ser Lys His Gly Asn Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Arg Thr Trp Asp Thr Ala Lys Lys Ile Glu Glu Lys Phe 
        195                 200                 205             


Lys Arg Ala Gln Leu Thr Leu Asp Lys Phe Phe Lys Lys Pro 
    210                 215                 220         


<210>  91
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  91

Met Lys Val Ala Gly Ile Asp Glu Ala Gly Arg Gly Ser Ala Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Ala Gln 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Ala Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Lys Val 
        115                 120                 125             


Val Ala Glu His Lys Ala Asp Ala Lys Tyr Glu Ile Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Arg Ala Phe Leu Glu Asn Tyr Tyr Arg Glu His Gly Glu Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Lys Gly Trp Lys Thr Leu Lys Lys Ile Ala Glu Lys Val 
        195                 200                 205             


Glu Ser Glu Lys Lys Ala Glu Glu Arg Gln Ala Thr Leu Asp Arg Tyr 
    210                 215                 220                 


Phe Arg Lys Val 
225             


<210>  92
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  92

Met Lys Val Ala Gly Ile Asp Glu Ala Gly Arg Gly Pro Ala Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Ala Arg 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Ala Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Lys Val 
        115                 120                 125             


Val Ala Glu His Lys Ala Asp Ala Lys Tyr Glu Ile Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Arg Ala Phe Leu Glu Asn Tyr Tyr Arg Glu His Gly Glu Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Lys Gly Trp Lys Thr Leu Lys Lys Ile Ala Glu Lys Val 
        195                 200                 205             


Glu Ser Glu Lys Lys Ala Glu Glu Arg Gln Ala Thr Leu Asp Arg Tyr 
    210                 215                 220                 


Phe Arg Lys Val 
225             


<210>  93
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  93

Met Lys Val Ala Gly Ile Asp Glu Ala Gly Arg Gly Pro Ala Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Ala Gln 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Val Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Lys Val 
        115                 120                 125             


Val Ala Glu His Lys Ala Asp Ala Lys Tyr Glu Ile Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Arg Ala Phe Leu Glu Asn Tyr Tyr Arg Glu His Gly Glu Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Lys Gly Trp Lys Thr Leu Lys Lys Ile Ala Glu Lys Val 
        195                 200                 205             


Glu Ser Glu Lys Lys Ala Glu Glu Arg Gln Ala Thr Leu Asp Arg Tyr 
    210                 215                 220                 


Phe Arg Lys Val 
225             


<210>  94
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  94

Met Lys Val Ala Gly Ile Asp Glu Ala Gly Arg Gly Ser Ala Ile Gly 
1               5                   10                  15      


Pro Leu Val Ile Val Ala Ala Val Val Asp Glu Asn Ser Leu Pro Lys 
            20                  25                  30          


Leu Glu Glu Leu Lys Val Arg Asp Ser Lys Lys Leu Thr Pro Ala Gln 
        35                  40                  45              


Arg Glu Lys Leu Phe Asp Glu Ile Val Lys Val Leu Asp Asp Tyr Ser 
    50                  55                  60                  


Val Val Ile Val Ser Pro Gln Asp Ile Asp Gly Arg Lys Gly Ser Met 
65                  70                  75                  80  


Asn Glu Leu Glu Val Glu Asn Phe Val Lys Ala Leu Asn Ser Leu Lys 
                85                  90                  95      


Val Lys Pro Asp Val Ile Tyr Ala Asp Ala Val Asp Val Asp Glu Glu 
            100                 105                 110         


Arg Phe Ala Arg Glu Leu Gly Glu Arg Leu Asn Phe Glu Ala Lys Val 
        115                 120                 125             


Val Ala Glu His Lys Ala Asp Ala Lys Tyr Glu Ile Val Ser Ala Ala 
    130                 135                 140                 


Ser Ile Leu Ala Lys Val Ile Arg Asp Arg Glu Ile Glu Lys Leu Lys 
145                 150                 155                 160 


Ala Glu Tyr Gly Asp Phe Gly Ser Gly Tyr Pro Ser Asp Pro Arg Thr 
                165                 170                 175     


Arg Ala Phe Leu Glu Asn Tyr Tyr Arg Glu His Gly Glu Phe Pro Pro 
            180                 185                 190         


Ile Val Arg Lys Gly Trp Lys Thr Leu Lys Lys Ile Ala Glu Lys Val 
        195                 200                 205             


Glu Ser Glu Lys Lys Ala Glu Glu Arg Gln Ala Thr Leu Asp Arg Tyr 
    210                 215                 220                 


Phe Arg Lys Val 
225             


<210>  95
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  95
atgaaagttg caggtgcaga tgaagctggt cgtggttctg ttattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccgaa gcgacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgga agttgtagcc aaacataaag cggatgacat ctttccggtc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactaa gaaatggctg      540

gaagaatggt atagcaaaca cggcaatttc ccgccgatcg tgcgtcgtac ttgggatact      600

gcaaagaaaa tcgaagaaaa attcaaacgt gcgcagctga ccctggacaa gttcttcaag      660

aaaccttga                                                              669


<210>  96
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  96
atgaaagttg caggtgcaga tgaagctggt cgtggtccag ttattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccgaa gcgacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg tagatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgga agttgtagcc aaacataaag cggatgacat ctttccggtc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactaa gaaatggctg      540

gaagaatggt atagcaaaca cggcaatttc ccgccgatcg tgcgtcgtac ttgggatact      600

gcaaagaaaa tcgaagaaaa attcaaacgt gcgcagctga ccctggacaa gttcttcaag      660

aaaccttga                                                              669


<210>  97
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  97
atgaaagttg caggtgcaga tgaagctggt cgtggttctg ttattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccgaa gcgacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg tagatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgga agttgtagcc aaacataaag cggatgacat ctttccggtc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactaa gaaatggctg      540

gaagaatggt atagcaaaca cggcaatttc ccgccgatcg tgcgtcgtac ttgggatact      600

gcaaagaaaa tcgaagaaaa attcaaacgt gcgcagctga ccctggacaa gttcttcaag      660

aaaccttga                                                              669


<210>  98
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  98
atgaaagttg caggtataga tgaagctggt cgtggttctg ctattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccggc gcaacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgaa agttgtagcc gaacataaag cggatgcgaa gtatgagatc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactag ggcattcctg      540

gaaaattact atagagaaca cggcgaattc ccgccgatcg tgcgtaaagg ttggaagact      600

ctaaagaaaa tcgcagaaaa agtcgaaagt gagaagaagg ctgaggaacg gcaggcgacc      660

ctggacaggt acttcaggaa ggtttga                                          687


<210>  99
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  99
atgaaagttg caggtataga tgaagctggt cgtggtccag ctattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccggc gcgccgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgc tgatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgaa agttgtagcc gaacataaag cggatgcgaa gtatgagatc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactag ggcattcctg      540

gaaaattact atagagaaca cggcgaattc ccgccgatcg tgcgtaaagg ttggaagact      600

ctaaagaaaa tcgcagaaaa agtcgaaagt gagaagaagg ctgaggaacg gcaggcgacc      660

ctggacaggt acttcaggaa ggtttga                                          687


<210>  100
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  100
atgaaagttg caggtataga tgaagctggt cgtggtccag ctattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccggc gcaacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgt agatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgaa agttgtagcc gaacataaag cggatgcgaa gtatgagatc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactag ggcattcctg      540

gaaaattact atagagaaca cggcgaattc ccgccgatcg tgcgtaaagg ttggaagact      600

ctaaagaaaa tcgcagaaaa agtcgaaagt gagaagaagg ctgaggaacg gcaggcgacc      660

ctggacaggt acttcaggaa ggtttga                                          687


<210>  101
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC SEQUENCE

<400>  101
atgaaagttg caggtataga tgaagctggt cgtggttctg ctattggtcc gctggttatt       60

gttgctgctg ttgtggatga aaacagtctc cccaagctgg aagagctgaa agttagagac      120

tccaaaaagc tgaccccggc gcaacgtgaa aaactgttcg atgaaatcgt aaaagtactg      180

gatgattact ctgtggtcat tgtgtccccg caggacattg acggtcgtaa gggcagcatg      240

aacgaactgg aggtagaaaa cttcgttaaa gccctgaata gcctgaaagt taagccggat      300

gttatttacg ctgatgccgt agatgttgat gaagaacgtt tcgctagaga gcttggcgag      360

cgtctgaact tcgaagcgaa agttgtagcc gaacataaag cggatgcgaa gtatgagatc      420

gtatccgcag cctctatcct ggcaaaagtt atccgtgacc gcgagatcga aaagctgaaa      480

gccgaatacg gtgattttgg ttccggttac ccgtctgatc cgcgtactag ggcattcctg      540

gaaaattact atagagaaca cggcgaattc ccgccgatcg tgcgtaaagg ttggaagact      600

ctaaagaaaa tcgcagaaaa agtcgaaagt gagaagaagg ctgaggaacg gcaggcgacc      660

ctggacaggt acttcaggaa ggtttga                                          687


