                         SEQUENCE LISTING

<110>  Massachusetts Institute of Technology
 
<120>  Modified Bacterium for Oxalate Degradation and Uses Thereof

<130>  21-1553-WO

<150>  63/129,776
<151>  2020-12-23

<150>  63/129,790
<151>  2020-12-23

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  891
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Ala Val Thr Asn Val Ala Glu Leu Asn Ala Leu Val Glu Arg Val 
1               5                   10                  15      


Lys Lys Ala Gln Arg Glu Tyr Ala Ser Phe Thr Gln Glu Gln Val Asp 
            20                  25                  30          


Lys Ile Phe Arg Ala Ala Ala Leu Ala Ala Ala Asp Ala Arg Ile Pro 
        35                  40                  45              


Leu Ala Lys Met Ala Val Ala Glu Ser Gly Met Gly Ile Val Glu Asp 
    50                  55                  60                  


Lys Val Ile Lys Asn His Phe Ala Ser Glu Tyr Ile Tyr Asn Ala Tyr 
65                  70                  75                  80  


Lys Asp Glu Lys Thr Cys Gly Val Leu Ser Glu Asp Asp Thr Phe Gly 
                85                  90                  95      


Thr Ile Thr Ile Ala Glu Pro Ile Gly Ile Ile Cys Gly Ile Val Pro 
            100                 105                 110         


Thr Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Ser Leu Ile Ser Leu 
        115                 120                 125             


Lys Thr Arg Asn Ala Ile Ile Phe Ser Pro His Pro Arg Ala Lys Asp 
    130                 135                 140                 


Ala Thr Asn Lys Ala Ala Asp Ile Val Leu Gln Ala Ala Ile Ala Ala 
145                 150                 155                 160 


Gly Ala Pro Lys Asp Leu Ile Gly Trp Ile Asp Gln Pro Ser Val Glu 
                165                 170                 175     


Leu Ser Asn Ala Leu Met His His Pro Asp Ile Asn Leu Ile Leu Ala 
            180                 185                 190         


Thr Gly Gly Pro Gly Met Val Lys Ala Ala Tyr Ser Ser Gly Lys Pro 
        195                 200                 205             


Ala Ile Gly Val Gly Ala Gly Asn Thr Pro Val Val Ile Asp Glu Thr 
    210                 215                 220                 


Ala Asp Ile Lys Arg Ala Val Ala Ser Val Leu Met Ser Lys Thr Phe 
225                 230                 235                 240 


Asp Asn Gly Val Ile Cys Ala Ser Glu Gln Ser Val Val Val Val Asp 
                245                 250                 255     


Ser Val Tyr Asp Ala Val Arg Glu Arg Phe Ala Thr His Gly Gly Tyr 
            260                 265                 270         


Leu Leu Gln Gly Lys Glu Leu Lys Ala Val Gln Asp Val Ile Leu Lys 
        275                 280                 285             


Asn Gly Ala Leu Asn Ala Ala Ile Val Gly Gln Pro Ala Tyr Lys Ile 
    290                 295                 300                 


Ala Glu Leu Ala Gly Phe Ser Val Pro Glu Asn Thr Lys Ile Leu Ile 
305                 310                 315                 320 


Gly Glu Val Thr Val Val Asp Glu Ser Glu Pro Phe Ala His Glu Lys 
                325                 330                 335     


Leu Ser Pro Thr Leu Ala Met Tyr Arg Ala Lys Asp Phe Glu Asp Ala 
            340                 345                 350         


Val Glu Lys Ala Glu Lys Leu Val Ala Met Gly Gly Ile Gly His Thr 
        355                 360                 365             


Ser Cys Leu Tyr Thr Asp Gln Asp Asn Gln Pro Ala Arg Val Ser Tyr 
    370                 375                 380                 


Phe Gly Gln Lys Met Lys Thr Ala Arg Ile Leu Ile Asn Thr Pro Ala 
385                 390                 395                 400 


Ser Gln Gly Gly Ile Gly Asp Leu Tyr Asn Phe Lys Leu Ala Pro Ser 
                405                 410                 415     


Leu Thr Leu Gly Cys Gly Ser Trp Gly Gly Asn Ser Ile Ser Glu Asn 
            420                 425                 430         


Val Gly Pro Lys His Leu Ile Asn Lys Lys Thr Val Ala Lys Arg Ala 
        435                 440                 445             


Glu Asn Met Leu Trp His Lys Leu Pro Lys Ser Ile Tyr Phe Arg Arg 
    450                 455                 460                 


Gly Ser Leu Pro Ile Ala Leu Asp Glu Val Ile Thr Asp Gly His Lys 
465                 470                 475                 480 


Arg Ala Leu Ile Val Thr Asp Arg Phe Leu Phe Asn Asn Gly Tyr Ala 
                485                 490                 495     


Asp Gln Ile Thr Ser Val Leu Lys Ala Ala Gly Val Glu Thr Glu Val 
            500                 505                 510         


Phe Phe Glu Val Glu Ala Asp Pro Thr Leu Ser Ile Val Arg Lys Gly 
        515                 520                 525             


Ala Glu Leu Ala Asn Ser Phe Lys Pro Asp Val Ile Ile Ala Leu Gly 
    530                 535                 540                 


Gly Gly Ser Pro Met Asp Ala Ala Lys Ile Met Trp Val Met Tyr Glu 
545                 550                 555                 560 


His Pro Glu Thr His Phe Glu Glu Leu Ala Leu Arg Phe Met Asp Ile 
                565                 570                 575     


Arg Lys Arg Ile Tyr Lys Phe Pro Lys Met Gly Val Lys Ala Lys Met 
            580                 585                 590         


Ile Ala Val Thr Thr Thr Ser Gly Thr Gly Ser Glu Val Thr Pro Phe 
        595                 600                 605             


Ala Val Val Thr Asp Asp Ala Thr Gly Gln Lys Tyr Pro Leu Ala Asp 
    610                 615                 620                 


Tyr Ala Leu Thr Pro Asp Met Ala Ile Val Asp Ala Asn Leu Val Met 
625                 630                 635                 640 


Asp Met Pro Lys Ser Leu Cys Ala Phe Gly Gly Leu Asp Ala Val Thr 
                645                 650                 655     


His Ala Met Glu Ala Tyr Val Ser Val Leu Ala Ser Glu Phe Ser Asp 
            660                 665                 670         


Gly Gln Ala Leu Gln Ala Leu Lys Leu Leu Lys Glu Tyr Leu Pro Ala 
        675                 680                 685             


Ser Tyr His Glu Gly Ser Lys Asn Pro Val Ala Arg Glu Arg Val His 
    690                 695                 700                 


Ser Ala Ala Thr Ile Ala Gly Ile Ala Phe Ala Asn Ala Phe Leu Gly 
705                 710                 715                 720 


Val Cys His Ser Met Ala His Lys Leu Gly Ser Gln Phe His Ile Pro 
                725                 730                 735     


His Gly Leu Ala Asn Ala Leu Leu Ile Cys Asn Val Ile Arg Tyr Asn 
            740                 745                 750         


Ala Asn Asp Asn Pro Thr Lys Gln Thr Ala Phe Ser Gln Tyr Asp Arg 
        755                 760                 765             


Pro Gln Ala Arg Arg Arg Tyr Ala Glu Ile Ala Asp His Leu Gly Leu 
    770                 775                 780                 


Ser Ala Pro Gly Asp Arg Thr Ala Ala Lys Ile Glu Lys Leu Leu Ala 
785                 790                 795                 800 


Trp Leu Glu Thr Leu Lys Ala Glu Leu Gly Ile Pro Lys Ser Ile Arg 
                805                 810                 815     


Glu Ala Gly Val Gln Glu Ala Asp Phe Leu Ala Asn Val Asp Lys Leu 
            820                 825                 830         


Ser Glu Asp Ala Phe Asp Asp Gln Cys Thr Gly Ala Asn Pro Arg Tyr 
        835                 840                 845             


Pro Leu Ile Ser Glu Leu Lys Gln Ile Leu Leu Asp Thr Tyr Tyr Gly 
    850                 855                 860                 


Arg Asp Tyr Val Glu Gly Glu Thr Ala Ala Lys Lys Glu Ala Ala Pro 
865                 870                 875                 880 


Ala Lys Ala Glu Lys Lys Ala Lys Lys Ser Ala 
                885                 890     


<210>  2
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Asn Gln Gln Asp Ile Glu Gln Val Val Lys Ala Val Leu Leu Lys 
1               5                   10                  15      


Met Gln Ser Ser Asp Thr Pro Ser Ala Ala Val His Glu Met Gly Val 
            20                  25                  30          


Phe Ala Ser Leu Asp Asp Ala Val Ala Ala Ala Lys Val Ala Gln Gln 
        35                  40                  45              


Gly Leu Lys Ser Val Ala Met Arg Gln Leu Ala Ile Ala Ala Ile Arg 
    50                  55                  60                  


Glu Ala Gly Glu Lys His Ala Arg Asp Leu Ala Glu Leu Ala Val Ser 
65                  70                  75                  80  


Glu Thr Gly Met Gly Arg Val Glu Asp Lys Phe Ala Lys Asn Val Ala 
                85                  90                  95      


Gln Ala Arg Gly Thr Pro Gly Val Glu Cys Leu Ser Pro Gln Val Leu 
            100                 105                 110         


Thr Gly Asp Asn Gly Leu Thr Leu Ile Glu Asn Ala Pro Trp Gly Val 
        115                 120                 125             


Val Ala Ser Val Thr Pro Ser Thr Asn Pro Ala Ala Thr Val Ile Asn 
    130                 135                 140                 


Asn Ala Ile Ser Leu Ile Ala Ala Gly Asn Ser Val Ile Phe Ala Pro 
145                 150                 155                 160 


His Pro Ala Ala Lys Lys Val Ser Gln Arg Ala Ile Thr Leu Leu Asn 
                165                 170                 175     


Gln Ala Ile Val Ala Ala Gly Gly Pro Glu Asn Leu Leu Val Thr Val 
            180                 185                 190         


Ala Asn Pro Asp Ile Glu Thr Ala Gln Arg Leu Phe Lys Phe Pro Gly 
        195                 200                 205             


Ile Gly Leu Leu Val Val Thr Gly Gly Glu Ala Val Val Glu Ala Ala 
    210                 215                 220                 


Arg Lys His Thr Asn Lys Arg Leu Ile Ala Ala Gly Ala Gly Asn Pro 
225                 230                 235                 240 


Pro Val Val Val Asp Glu Thr Ala Asp Leu Ala Arg Ala Ala Gln Ser 
                245                 250                 255     


Ile Val Lys Gly Ala Ser Phe Asp Asn Asn Ile Ile Cys Ala Asp Glu 
            260                 265                 270         


Lys Val Leu Ile Val Val Asp Ser Val Ala Asp Glu Leu Met Arg Leu 
        275                 280                 285             


Met Glu Gly Gln His Ala Val Lys Leu Thr Ala Glu Gln Ala Gln Gln 
    290                 295                 300                 


Leu Gln Pro Val Leu Leu Lys Asn Ile Asp Glu Arg Gly Lys Gly Thr 
305                 310                 315                 320 


Val Ser Arg Asp Trp Val Gly Arg Asp Ala Gly Lys Ile Ala Ala Ala 
                325                 330                 335     


Ile Gly Leu Lys Val Pro Gln Glu Thr Arg Leu Leu Phe Val Glu Thr 
            340                 345                 350         


Thr Ala Glu His Pro Phe Ala Val Thr Glu Leu Met Met Pro Val Leu 
        355                 360                 365             


Pro Val Val Arg Val Ala Asn Val Ala Asp Ala Ile Ala Leu Ala Val 
    370                 375                 380                 


Lys Leu Glu Gly Gly Cys His His Thr Ala Ala Met His Ser Arg Asn 
385                 390                 395                 400 


Ile Glu Asn Met Asn Gln Met Ala Asn Ala Ile Asp Thr Ser Ile Phe 
                405                 410                 415     


Val Lys Asn Gly Pro Cys Ile Ala Gly Leu Gly Leu Gly Gly Glu Gly 
            420                 425                 430         


Trp Thr Thr Met Thr Ile Thr Thr Pro Thr Gly Glu Gly Val Thr Ser 
        435                 440                 445             


Ala Arg Thr Phe Val Arg Leu Arg Arg Cys Val Leu Val Asp Ala Phe 
    450                 455                 460                 


Arg Ile Val 
465         


<210>  3
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Lys Leu Ala Val Val Thr Gly Gln Ile Val Cys Thr Val Arg His 
1               5                   10                  15      


His Gly Leu Ala His Asp Lys Leu Leu Met Val Glu Met Ile Asp Pro 
            20                  25                  30          


Gln Gly Asn Pro Asp Gly Gln Cys Ala Val Ala Ile Asp Asn Ile Gly 
        35                  40                  45              


Ala Gly Thr Gly Glu Trp Val Leu Leu Val Ser Gly Ser Ser Ala Arg 
    50                  55                  60                  


Gln Ala His Lys Ser Glu Thr Ser Pro Val Asp Leu Cys Val Ile Gly 
65                  70                  75                  80  


Ile Val Asp Glu Val Val Ser Gly Gly Gln Val Ile Phe His Lys 
                85                  90                  95  


<210>  4
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Ser Ser Phe Asp Tyr Leu Lys Thr Ala Ile Lys Gln Gln Gly Cys 
1               5                   10                  15      


Thr Leu Gln Gln Val Ala Asp Ala Ser Gly Met Thr Lys Gly Tyr Leu 
            20                  25                  30          


Ser Gln Leu Leu Asn Ala Lys Ile Lys Ser Pro Ser Ala Gln Lys Leu 
        35                  40                  45              


Glu Ala Leu His Arg Phe Leu Gly Leu Glu Phe Pro Arg Gln Lys Lys 
    50                  55                  60                  


Thr Ile Gly Val Val Phe Gly Lys Phe Tyr Pro Leu His Thr Gly His 
65                  70                  75                  80  


Ile Tyr Leu Ile Gln Arg Ala Cys Ser Gln Val Asp Glu Leu His Ile 
                85                  90                  95      


Ile Met Gly Phe Asp Asp Thr Arg Asp Arg Ala Leu Phe Glu Asp Ser 
            100                 105                 110         


Ala Met Ser Gln Gln Pro Thr Val Pro Asp Arg Leu Arg Trp Leu Leu 
        115                 120                 125             


Gln Thr Phe Lys Tyr Gln Lys Asn Ile Arg Ile His Ala Phe Asn Glu 
    130                 135                 140                 


Glu Gly Met Glu Pro Tyr Pro His Gly Trp Asp Val Trp Ser Asn Gly 
145                 150                 155                 160 


Ile Lys Lys Phe Met Ala Glu Lys Gly Ile Gln Pro Asp Leu Ile Tyr 
                165                 170                 175     


Thr Ser Glu Glu Ala Asp Ala Pro Gln Tyr Met Glu His Leu Gly Ile 
            180                 185                 190         


Glu Thr Val Leu Val Asp Pro Lys Arg Thr Phe Met Ser Ile Ser Gly 
        195                 200                 205             


Ala Gln Ile Arg Glu Asn Pro Phe Arg Tyr Trp Glu Tyr Ile Pro Thr 
    210                 215                 220                 


Glu Val Lys Pro Phe Phe Val Arg Thr Val Ala Ile Leu Gly Gly Glu 
225                 230                 235                 240 


Ser Ser Gly Lys Ser Thr Leu Val Asn Lys Leu Ala Asn Ile Phe Asn 
                245                 250                 255     


Thr Thr Ser Ala Trp Glu Tyr Gly Arg Asp Tyr Val Phe Ser His Leu 
            260                 265                 270         


Gly Gly Asp Glu Ile Ala Leu Gln Tyr Ser Asp Tyr Asp Lys Ile Ala 
        275                 280                 285             


Leu Gly His Ala Gln Tyr Ile Asp Phe Ala Val Lys Tyr Ala Asn Lys 
    290                 295                 300                 


Val Ala Phe Ile Asp Thr Asp Phe Val Thr Thr Gln Ala Phe Cys Lys 
305                 310                 315                 320 


Lys Tyr Glu Gly Arg Glu His Pro Phe Val Gln Ala Leu Ile Asp Glu 
                325                 330                 335     


Tyr Arg Phe Asp Leu Val Ile Leu Leu Glu Asn Asn Thr Pro Trp Val 
            340                 345                 350         


Ala Asp Gly Leu Arg Ser Leu Gly Ser Ser Val Asp Arg Lys Glu Phe 
        355                 360                 365             


Gln Asn Leu Leu Val Glu Met Leu Glu Glu Asn Asn Ile Glu Phe Val 
    370                 375                 380                 


Arg Val Glu Glu Glu Asp Tyr Asp Ser Arg Phe Leu Arg Cys Val Glu 
385                 390                 395                 400 


Leu Val Arg Glu Met Met Gly Glu Gln Arg 
                405                 410 


<210>  5
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Pro His Ser Tyr Asp Tyr Asp Ala Ile Val Ile Gly Ser Gly Pro 
1               5                   10                  15      


Gly Gly Glu Gly Ala Ala Met Gly Leu Val Lys Gln Gly Ala Arg Val 
            20                  25                  30          


Ala Val Ile Glu Arg Tyr Gln Asn Val Gly Gly Gly Cys Thr His Trp 
        35                  40                  45              


Gly Thr Ile Pro Ser Lys Ala Leu Arg His Ala Val Ser Arg Ile Ile 
    50                  55                  60                  


Glu Phe Asn Gln Asn Pro Leu Tyr Ser Asp His Ser Arg Leu Leu Arg 
65                  70                  75                  80  


Ser Ser Phe Ala Asp Ile Leu Asn His Ala Asp Asn Val Ile Asn Gln 
                85                  90                  95      


Gln Thr Arg Met Arg Gln Gly Phe Tyr Glu Arg Asn His Cys Glu Ile 
            100                 105                 110         


Leu Gln Gly Asn Ala Arg Phe Val Asp Glu His Thr Leu Ala Leu Asp 
        115                 120                 125             


Cys Pro Asp Gly Ser Val Glu Thr Leu Thr Ala Glu Lys Phe Val Ile 
    130                 135                 140                 


Ala Cys Gly Ser Arg Pro Tyr His Pro Thr Asp Val Asp Phe Thr His 
145                 150                 155                 160 


Pro Arg Ile Tyr Asp Ser Asp Ser Ile Leu Ser Met His His Glu Pro 
                165                 170                 175     


Arg His Val Leu Ile Tyr Gly Ala Gly Val Ile Gly Cys Glu Tyr Ala 
            180                 185                 190         


Ser Ile Phe Arg Gly Met Asp Val Lys Val Asp Leu Ile Asn Thr Arg 
        195                 200                 205             


Asp Arg Leu Leu Ala Phe Leu Asp Gln Glu Met Ser Asp Ser Leu Ser 
    210                 215                 220                 


Tyr His Phe Trp Asn Ser Gly Val Val Ile Arg His Asn Glu Glu Tyr 
225                 230                 235                 240 


Glu Lys Ile Glu Gly Cys Asp Asp Gly Val Ile Met His Leu Lys Ser 
                245                 250                 255     


Gly Lys Lys Leu Lys Ala Asp Cys Leu Leu Tyr Ala Asn Gly Arg Thr 
            260                 265                 270         


Gly Asn Thr Asp Ser Leu Ala Leu Gln Asn Ile Gly Leu Glu Thr Asp 
        275                 280                 285             


Ser Arg Gly Gln Leu Lys Val Asn Ser Met Tyr Gln Thr Ala Gln Pro 
    290                 295                 300                 


His Val Tyr Ala Val Gly Asp Val Ile Gly Tyr Pro Ser Leu Ala Ser 
305                 310                 315                 320 


Ala Ala Tyr Asp Gln Gly Arg Ile Ala Ala Gln Ala Leu Val Lys Gly 
                325                 330                 335     


Glu Ala Thr Ala His Leu Ile Glu Asp Ile Pro Thr Gly Ile Tyr Thr 
            340                 345                 350         


Ile Pro Glu Ile Ser Ser Val Gly Lys Thr Glu Gln Gln Leu Thr Ala 
        355                 360                 365             


Met Lys Val Pro Tyr Glu Val Gly Arg Ala Gln Phe Lys His Leu Ala 
    370                 375                 380                 


Arg Ala Gln Ile Val Gly Met Asn Val Gly Thr Leu Lys Ile Leu Phe 
385                 390                 395                 400 


His Arg Glu Thr Lys Glu Ile Leu Gly Ile His Cys Phe Gly Glu Arg 
                405                 410                 415     


Ala Ala Glu Ile Ile His Ile Gly Gln Ala Ile Met Glu Gln Lys Gly 
            420                 425                 430         


Gly Gly Asn Thr Ile Glu Tyr Phe Val Asn Thr Thr Phe Asn Tyr Pro 
        435                 440                 445             


Thr Met Ala Glu Ala Tyr Arg Val Ala Ala Leu Asn Gly Leu Asn Arg 
    450                 455                 460                 


Leu Phe 
465     


<210>  6
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Glu Ser Lys Val Val Val Pro Ala Gln Gly Lys Lys Ile Thr Leu 
1               5                   10                  15      


Gln Asn Gly Lys Leu Asn Val Pro Glu Asn Pro Ile Ile Pro Tyr Ile 
            20                  25                  30          


Glu Gly Asp Gly Ile Gly Val Asp Val Thr Pro Ala Met Leu Lys Val 
        35                  40                  45              


Val Asp Ala Ala Val Glu Lys Ala Tyr Lys Gly Glu Arg Lys Ile Ser 
    50                  55                  60                  


Trp Met Glu Ile Tyr Thr Gly Glu Lys Ser Thr Gln Val Tyr Gly Gln 
65                  70                  75                  80  


Asp Val Trp Leu Pro Ala Glu Thr Leu Asp Leu Ile Arg Glu Tyr Arg 
                85                  90                  95      


Val Ala Ile Lys Gly Pro Leu Thr Thr Pro Val Gly Gly Gly Ile Arg 
            100                 105                 110         


Ser Leu Asn Val Ala Leu Arg Gln Glu Leu Asp Leu Tyr Ile Cys Leu 
        115                 120                 125             


Arg Pro Val Arg Tyr Tyr Gln Gly Thr Pro Ser Pro Val Lys His Pro 
    130                 135                 140                 


Glu Leu Thr Asp Met Val Ile Phe Arg Glu Asn Ser Glu Asp Ile Tyr 
145                 150                 155                 160 


Ala Gly Ile Glu Trp Lys Ala Asp Ser Ala Asp Ala Glu Lys Val Ile 
                165                 170                 175     


Lys Phe Leu Arg Glu Glu Met Gly Val Lys Lys Ile Arg Phe Pro Glu 
            180                 185                 190         


His Cys Gly Ile Gly Ile Lys Pro Cys Ser Glu Glu Gly Thr Lys Arg 
        195                 200                 205             


Leu Val Arg Ala Ala Ile Glu Tyr Ala Ile Ala Asn Asp Arg Asp Ser 
    210                 215                 220                 


Val Thr Leu Val His Lys Gly Asn Ile Met Lys Phe Thr Glu Gly Ala 
225                 230                 235                 240 


Phe Lys Asp Trp Gly Tyr Gln Leu Ala Arg Glu Glu Phe Gly Gly Glu 
                245                 250                 255     


Leu Ile Asp Gly Gly Pro Trp Leu Lys Val Lys Asn Pro Asn Thr Gly 
            260                 265                 270         


Lys Glu Ile Val Ile Lys Asp Val Ile Ala Asp Ala Phe Leu Gln Gln 
        275                 280                 285             


Ile Leu Leu Arg Pro Ala Glu Tyr Asp Val Ile Ala Cys Met Asn Leu 
    290                 295                 300                 


Asn Gly Asp Tyr Ile Ser Asp Ala Leu Ala Ala Gln Val Gly Gly Ile 
305                 310                 315                 320 


Gly Ile Ala Pro Gly Ala Asn Ile Gly Asp Glu Cys Ala Leu Phe Glu 
                325                 330                 335     


Ala Thr His Gly Thr Ala Pro Lys Tyr Ala Gly Gln Asp Lys Val Asn 
            340                 345                 350         


Pro Gly Ser Ile Ile Leu Ser Ala Glu Met Met Leu Arg His Met Gly 
        355                 360                 365             


Trp Thr Glu Ala Ala Asp Leu Ile Val Lys Gly Met Glu Gly Ala Ile 
    370                 375                 380                 


Asn Ala Lys Thr Val Thr Tyr Asp Phe Glu Arg Leu Met Asp Gly Ala 
385                 390                 395                 400 


Lys Leu Leu Lys Cys Ser Glu Phe Gly Asp Ala Ile Ile Glu Asn Met 
                405                 410                 415     


<210>  7
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Pro Arg Gly Leu Glu Leu Leu Ile Ala Gln Thr Ile Leu Gln Gly 
1               5                   10                  15      


Phe Asp Ala Gln Tyr Gly Arg Phe Leu Glu Val Thr Ser Gly Ala Gln 
            20                  25                  30          


Gln Arg Phe Glu Gln Ala Asp Trp His Ala Val Gln Gln Ala Met Lys 
        35                  40                  45              


Asn Arg Ile His Leu Tyr Asp His His Val Gly Leu Val Val Glu Gln 
    50                  55                  60                  


Leu Arg Cys Ile Thr Asn Gly Gln Ser Thr Asp Ala Ala Phe Leu Leu 
65                  70                  75                  80  


Arg Val Lys Glu His Tyr Thr Arg Leu Leu Pro Asp Tyr Pro Arg Phe 
                85                  90                  95      


Glu Ile Ala Glu Ser Phe Phe Asn Ser Val Tyr Cys Arg Leu Phe Asp 
            100                 105                 110         


His Arg Ser Leu Thr Pro Glu Arg Leu Phe Ile Phe Ser Ser Gln Pro 
        115                 120                 125             


Glu Arg Arg Phe Arg Thr Ile Pro Arg Pro Leu Ala Lys Asp Phe His 
    130                 135                 140                 


Pro Asp His Gly Trp Glu Ser Leu Leu Met Arg Val Ile Ser Asp Leu 
145                 150                 155                 160 


Pro Leu Arg Leu Arg Trp Gln Asn Lys Ser Arg Asp Ile His Tyr Ile 
                165                 170                 175     


Ile Arg His Leu Thr Glu Thr Leu Gly Thr Asp Asn Leu Ala Glu Ser 
            180                 185                 190         


His Leu Gln Val Ala Asn Glu Leu Phe Tyr Arg Asn Lys Ala Ala Trp 
        195                 200                 205             


Leu Val Gly Lys Leu Ile Thr Pro Ser Gly Thr Leu Pro Phe Leu Leu 
    210                 215                 220                 


Pro Ile His Gln Thr Asp Asp Gly Glu Leu Phe Ile Asp Thr Cys Leu 
225                 230                 235                 240 


Thr Thr Thr Ala Glu Ala Ser Ile Val Phe Gly Phe Ala Arg Ser Tyr 
                245                 250                 255     


Phe Met Val Tyr Ala Pro Leu Pro Ala Ala Leu Val Glu Trp Leu Arg 
            260                 265                 270         


Glu Ile Leu Pro Gly Lys Thr Thr Ala Glu Leu Tyr Met Ala Ile Gly 
        275                 280                 285             


Cys Gln Lys His Ala Lys Thr Glu Ser Tyr Arg Glu Tyr Leu Val Tyr 
    290                 295                 300                 


Leu Gln Gly Cys Asn Glu Gln Phe Ile Glu Ala Pro Gly Ile Arg Gly 
305                 310                 315                 320 


Met Val Met Leu Val Phe Thr Leu Pro Gly Phe Asp Arg Val Phe Lys 
                325                 330                 335     


Val Ile Lys Asp Arg Phe Ala Pro Gln Lys Glu Met Ser Ala Ala His 
            340                 345                 350         


Val Arg Ala Cys Tyr Gln Leu Val Lys Glu His Asp Arg Val Gly Arg 
        355                 360                 365             


Met Ala Asp Thr Gln Glu Phe Glu Asn Phe Val Leu Glu Lys Arg His 
    370                 375                 380                 


Ile Ser Pro Ala Leu Met Glu Leu Leu Leu Gln Glu Ala Ala Glu Lys 
385                 390                 395                 400 


Ile Thr Asp Leu Gly Glu Gln Ile Val Ile Arg His Leu Tyr Ile Glu 
                405                 410                 415     


Arg Arg Met Val Pro Leu Asn Ile Trp Leu Glu Gln Val Glu Gly Gln 
            420                 425                 430         


Gln Leu Arg Asp Ala Ile Glu Glu Tyr Gly Asn Ala Ile Arg Gln Leu 
        435                 440                 445             


Ala Ala Ala Asn Ile Phe Pro Gly Asp Met Leu Phe Lys Asn Phe Gly 
    450                 455                 460                 


Val Thr Arg His Gly Arg Val Val Phe Tyr Asp Tyr Asp Glu Ile Cys 
465                 470                 475                 480 


Tyr Met Thr Glu Val Asn Phe Arg Asp Ile Pro Pro Pro Arg Tyr Pro 
                485                 490                 495     


Glu Asp Glu Leu Ala Ser Glu Pro Trp Tyr Ser Val Ser Pro Gly Asp 
            500                 505                 510         


Val Phe Pro Glu Glu Phe Arg His Trp Leu Cys Ala Asp Pro Arg Ile 
        515                 520                 525             


Gly Pro Leu Phe Glu Glu Met His Ala Asp Leu Phe Arg Ala Asp Tyr 
    530                 535                 540                 


Trp Arg Ala Leu Gln Asn Arg Ile Arg Glu Gly His Val Glu Asp Val 
545                 550                 555                 560 


Tyr Ala Tyr Arg Arg Arg Gln Arg Phe Ser Val Arg Tyr Gly Glu Met 
                565                 570                 575     


Leu Phe 
        


<210>  8
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Val Ala Pro Ile Pro Ala Lys Arg Gly Arg Lys Pro Ala Val Ala 
1               5                   10                  15      


Thr Ala Pro Ala Thr Gly Gln Val Gln Ser Leu Thr Arg Gly Leu Lys 
            20                  25                  30          


Leu Leu Glu Trp Ile Ala Glu Ser Asn Gly Ser Val Ala Leu Thr Glu 
        35                  40                  45              


Leu Ala Gln Gln Ala Gly Leu Pro Asn Ser Thr Thr His Arg Leu Leu 
    50                  55                  60                  


Thr Thr Met Gln Gln Gln Gly Phe Val Arg Gln Val Gly Glu Leu Gly 
65                  70                  75                  80  


His Trp Ala Ile Gly Ala His Ala Phe Met Val Gly Ser Ser Phe Leu 
                85                  90                  95      


Gln Ser Arg Asn Leu Leu Ala Ile Val His Pro Ile Leu Arg Asn Leu 
            100                 105                 110         


Met Glu Glu Ser Gly Glu Thr Val Asn Met Ala Val Leu Asp Gln Ser 
        115                 120                 125             


Asp His Glu Ala Ile Ile Ile Asp Gln Val Gln Cys Thr His Leu Met 
    130                 135                 140                 


Arg Met Ser Ala Pro Ile Gly Gly Lys Leu Pro Met His Ala Ser Gly 
145                 150                 155                 160 


Ala Gly Lys Ala Phe Leu Ala Gln Leu Ser Glu Glu Gln Val Thr Lys 
                165                 170                 175     


Leu Leu His Arg Lys Gly Leu His Ala Tyr Thr His Ala Thr Leu Val 
            180                 185                 190         


Ser Pro Val His Leu Lys Glu Asp Leu Ala Gln Thr Arg Lys Arg Gly 
        195                 200                 205             


Tyr Ser Phe Asp Asp Glu Glu His Ala Leu Gly Leu Arg Cys Leu Ala 
    210                 215                 220                 


Ala Cys Ile Phe Asp Glu His Arg Glu Pro Phe Ala Ala Ile Ser Ile 
225                 230                 235                 240 


Ser Gly Pro Ile Ser Arg Ile Thr Asp Asp Arg Val Thr Glu Phe Gly 
                245                 250                 255     


Ala Met Val Ile Lys Ala Ala Lys Glu Val Thr Leu Ala Tyr Gly Gly 
            260                 265                 270         


Met Arg 
        


<210>  9
<211>  1342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Val Tyr Ser Tyr Thr Glu Lys Lys Arg Ile Arg Lys Asp Phe Gly 
1               5                   10                  15      


Lys Arg Pro Gln Val Leu Asp Val Pro Tyr Leu Leu Ser Ile Gln Leu 
            20                  25                  30          


Asp Ser Phe Gln Lys Phe Ile Glu Gln Asp Pro Glu Gly Gln Tyr Gly 
        35                  40                  45              


Leu Glu Ala Ala Phe Arg Ser Val Phe Pro Ile Gln Ser Tyr Ser Gly 
    50                  55                  60                  


Asn Ser Glu Leu Gln Tyr Val Ser Tyr Arg Leu Gly Glu Pro Val Phe 
65                  70                  75                  80  


Asp Val Gln Glu Cys Gln Ile Arg Gly Val Thr Tyr Ser Ala Pro Leu 
                85                  90                  95      


Arg Val Lys Leu Arg Leu Val Ile Tyr Glu Arg Glu Ala Pro Glu Gly 
            100                 105                 110         


Thr Val Lys Asp Ile Lys Glu Gln Glu Val Tyr Met Gly Glu Ile Pro 
        115                 120                 125             


Leu Met Thr Asp Asn Gly Thr Phe Val Ile Asn Gly Thr Glu Arg Val 
    130                 135                 140                 


Ile Val Ser Gln Leu His Arg Ser Pro Gly Val Phe Phe Asp Ser Asp 
145                 150                 155                 160 


Lys Gly Lys Thr His Ser Ser Gly Lys Val Leu Tyr Asn Ala Arg Ile 
                165                 170                 175     


Ile Pro Tyr Arg Gly Ser Trp Leu Asp Phe Glu Phe Asp Pro Lys Asp 
            180                 185                 190         


Asn Leu Phe Val Arg Ile Asp Arg Arg Arg Lys Leu Pro Ala Thr Ile 
        195                 200                 205             


Ile Leu Arg Ala Leu Asn Tyr Thr Thr Glu Gln Ile Leu Asp Leu Phe 
    210                 215                 220                 


Phe Glu Lys Val Ile Phe Glu Ile Arg Asp Asn Lys Leu Gln Met Glu 
225                 230                 235                 240 


Leu Val Pro Glu Arg Leu Arg Gly Glu Thr Ala Ser Phe Asp Ile Glu 
                245                 250                 255     


Ala Asn Gly Lys Val Tyr Val Glu Lys Gly Arg Arg Ile Thr Ala Arg 
            260                 265                 270         


His Ile Arg Gln Leu Glu Lys Asp Asp Val Lys Leu Ile Glu Val Pro 
        275                 280                 285             


Val Glu Tyr Ile Ala Gly Lys Val Val Ala Lys Asp Tyr Ile Asp Glu 
    290                 295                 300                 


Ser Thr Gly Glu Leu Ile Cys Ala Ala Asn Met Glu Leu Ser Leu Asp 
305                 310                 315                 320 


Leu Leu Ala Lys Leu Ser Gln Ser Gly His Lys Arg Ile Glu Thr Leu 
                325                 330                 335     


Phe Thr Asn Asp Leu Asp His Gly Pro Tyr Ile Ser Glu Thr Leu Arg 
            340                 345                 350         


Val Asp Pro Thr Asn Asp Arg Leu Ser Ala Leu Val Glu Ile Tyr Arg 
        355                 360                 365             


Met Met Arg Pro Gly Glu Pro Pro Thr Arg Glu Ala Ala Glu Ser Leu 
    370                 375                 380                 


Phe Glu Asn Leu Phe Phe Ser Glu Asp Arg Tyr Asp Leu Ser Ala Val 
385                 390                 395                 400 


Gly Arg Met Lys Phe Asn Arg Ser Leu Leu Arg Glu Glu Ile Glu Gly 
                405                 410                 415     


Ser Gly Ile Leu Ser Lys Asp Asp Ile Ile Asp Val Met Lys Lys Leu 
            420                 425                 430         


Ile Asp Ile Arg Asn Gly Lys Gly Glu Val Asp Asp Ile Asp His Leu 
        435                 440                 445             


Gly Asn Arg Arg Ile Arg Ser Val Gly Glu Met Ala Glu Asn Gln Phe 
    450                 455                 460                 


Arg Val Gly Leu Val Arg Val Glu Arg Ala Val Lys Glu Arg Leu Ser 
465                 470                 475                 480 


Leu Gly Asp Leu Asp Thr Leu Met Pro Gln Asp Met Ile Asn Ala Lys 
                485                 490                 495     


Pro Ile Ser Ala Ala Val Lys Glu Phe Phe Gly Ser Ser Gln Leu Ser 
            500                 505                 510         


Gln Phe Met Asp Gln Asn Asn Pro Leu Ser Glu Ile Thr His Lys Arg 
        515                 520                 525             


Arg Ile Ser Ala Leu Gly Pro Gly Gly Leu Thr Arg Glu Arg Ala Gly 
    530                 535                 540                 


Phe Glu Val Arg Asp Val His Pro Thr His Tyr Gly Arg Val Cys Pro 
545                 550                 555                 560 


Ile Glu Thr Pro Glu Gly Pro Asn Ile Gly Leu Ile Asn Ser Leu Ser 
                565                 570                 575     


Val Tyr Ala Gln Thr Asn Glu Tyr Gly Phe Leu Glu Thr Pro Tyr Arg 
            580                 585                 590         


Lys Val Thr Asp Gly Val Val Thr Asp Glu Ile His Tyr Leu Ser Ala 
        595                 600                 605             


Ile Glu Glu Gly Asn Tyr Val Ile Ala Gln Ala Asn Ser Asn Leu Asp 
    610                 615                 620                 


Glu Glu Gly His Phe Val Glu Asp Leu Val Thr Cys Arg Ser Lys Gly 
625                 630                 635                 640 


Glu Ser Ser Leu Phe Ser Arg Asp Gln Val Asp Tyr Met Asp Val Ser 
                645                 650                 655     


Thr Gln Gln Val Val Ser Val Gly Ala Ser Leu Ile Pro Phe Leu Glu 
            660                 665                 670         


His Asp Asp Ala Asn Arg Ala Leu Met Gly Ala Asn Met Gln Arg Gln 
        675                 680                 685             


Ala Val Pro Thr Leu Arg Ala Asp Lys Pro Leu Val Gly Thr Gly Met 
    690                 695                 700                 


Glu Arg Ala Val Ala Val Asp Ser Gly Val Thr Ala Val Ala Lys Arg 
705                 710                 715                 720 


Gly Gly Val Val Gln Tyr Val Asp Ala Ser Arg Ile Val Ile Lys Val 
                725                 730                 735     


Asn Glu Asp Glu Met Tyr Pro Gly Glu Ala Gly Ile Asp Ile Tyr Asn 
            740                 745                 750         


Leu Thr Lys Tyr Thr Arg Ser Asn Gln Asn Thr Cys Ile Asn Gln Met 
        755                 760                 765             


Pro Cys Val Ser Leu Gly Glu Pro Val Glu Arg Gly Asp Val Leu Ala 
    770                 775                 780                 


Asp Gly Pro Ser Thr Asp Leu Gly Glu Leu Ala Leu Gly Gln Asn Met 
785                 790                 795                 800 


Arg Val Ala Phe Met Pro Trp Asn Gly Tyr Asn Phe Glu Asp Ser Ile 
                805                 810                 815     


Leu Val Ser Glu Arg Val Val Gln Glu Asp Arg Phe Thr Thr Ile His 
            820                 825                 830         


Ile Gln Glu Leu Ala Cys Val Ser Arg Asp Thr Lys Leu Gly Pro Glu 
        835                 840                 845             


Glu Ile Thr Ala Asp Ile Pro Asn Val Gly Glu Ala Ala Leu Ser Lys 
    850                 855                 860                 


Leu Asp Glu Ser Gly Ile Val Tyr Ile Gly Ala Glu Val Thr Gly Gly 
865                 870                 875                 880 


Asp Ile Leu Val Gly Lys Val Thr Pro Lys Gly Glu Thr Gln Leu Thr 
                885                 890                 895     


Pro Glu Glu Lys Leu Leu Arg Ala Ile Phe Gly Glu Lys Ala Ser Asp 
            900                 905                 910         


Val Lys Asp Ser Ser Leu Arg Val Pro Asn Gly Val Ser Gly Thr Val 
        915                 920                 925             


Ile Asp Val Gln Val Phe Thr Arg Asp Gly Val Glu Lys Asp Lys Arg 
    930                 935                 940                 


Ala Leu Glu Ile Glu Glu Met Gln Leu Lys Gln Ala Lys Lys Asp Leu 
945                 950                 955                 960 


Ser Glu Glu Leu Gln Ile Leu Glu Ala Gly Leu Phe Ser Arg Ile Arg 
                965                 970                 975     


Ala Val Leu Val Ala Gly Gly Val Glu Ala Glu Lys Leu Asp Lys Leu 
            980                 985                 990         


Pro Arg Asp Arg Trp Leu Glu Leu  Gly Leu Thr Asp Glu  Glu Lys Gln 
        995                 1000                 1005             


Asn Gln  Leu Glu Gln Leu Ala  Glu Gln Tyr Asp Glu  Leu Lys His 
    1010                 1015                 1020             


Glu Phe  Glu Lys Lys Leu Glu  Ala Lys Arg Arg Lys  Ile Thr Gln 
    1025                 1030                 1035             


Gly Asp  Asp Leu Ala Pro Gly  Val Leu Lys Ile Val  Lys Val Tyr 
    1040                 1045                 1050             


Leu Ala  Val Lys Arg Arg Ile  Gln Pro Gly Asp Lys  Met Ala Gly 
    1055                 1060                 1065             


Arg His  Gly Asn Lys Gly Val  Ile Ser Lys Ile Asn  Pro Ile Glu 
    1070                 1075                 1080             


Asp Met  Pro Tyr Asp Glu Asn  Gly Thr Pro Val Asp  Ile Val Leu 
    1085                 1090                 1095             


Asn Pro  Leu Gly Val Pro Ser  Arg Met Asn Ile Gly  Gln Ile Leu 
    1100                 1105                 1110             


Glu Thr  His Leu Gly Met Ala  Ala Lys Gly Ile Gly  Asp Lys Ile 
    1115                 1120                 1125             


Asn Ala  Met Leu Lys Gln Gln  Gln Glu Val Ala Lys  Leu Arg Glu 
    1130                 1135                 1140             


Phe Ile  Gln Arg Ala Tyr Asp  Leu Gly Ala Asp Val  Arg Gln Lys 
    1145                 1150                 1155             


Val Asp  Leu Ser Thr Phe Ser  Asp Glu Glu Val Met  Arg Leu Ala 
    1160                 1165                 1170             


Glu Asn  Leu Arg Lys Gly Met  Pro Ile Ala Thr Pro  Val Phe Asp 
    1175                 1180                 1185             


Gly Ala  Lys Glu Ala Glu Ile  Lys Glu Leu Leu Lys  Leu Gly Asp 
    1190                 1195                 1200             


Leu Pro  Thr Ser Gly Gln Ile  Arg Leu Tyr Asp Gly  Arg Thr Gly 
    1205                 1210                 1215             


Glu Gln  Phe Glu Arg Pro Val  Thr Val Gly Tyr Met  Tyr Met Leu 
    1220                 1225                 1230             


Lys Leu  Asn His Leu Val Asp  Asp Lys Met His Ala  Arg Ser Thr 
    1235                 1240                 1245             


Gly Ser  Tyr Ser Leu Val Thr  Gln Gln Pro Leu Gly  Gly Lys Ala 
    1250                 1255                 1260             


Gln Phe  Gly Gly Gln Arg Phe  Gly Glu Met Glu Val  Trp Ala Leu 
    1265                 1270                 1275             


Glu Ala  Tyr Gly Ala Ala Tyr  Thr Leu Gln Glu Met  Leu Thr Val 
    1280                 1285                 1290             


Lys Ser  Asp Asp Val Asn Gly  Arg Thr Lys Met Tyr  Lys Asn Ile 
    1295                 1300                 1305             


Val Asp  Gly Asn His Gln Met  Glu Pro Gly Met Pro  Glu Ser Phe 
    1310                 1315                 1320             


Asn Val  Leu Leu Lys Glu Ile  Arg Ser Leu Gly Ile  Asn Ile Glu 
    1325                 1330                 1335             


Leu Glu  Asp Glu 
    1340         


<210>  10
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Ser Gln Asn Thr Leu Lys Val His Asp Leu Asn Glu Asp Ala Glu 
1               5                   10                  15      


Phe Asp Glu Asn Gly Val Glu Val Phe Asp Glu Lys Ala Leu Val Glu 
            20                  25                  30          


Gln Glu Pro Ser Asp Asn Asp Leu Ala Glu Glu Glu Leu Leu Ser Gln 
        35                  40                  45              


Gly Ala Thr Gln Arg Val Leu Asp Ala Thr Gln Leu Tyr Leu Gly Glu 
    50                  55                  60                  


Ile Gly Tyr Ser Pro Leu Leu Thr Ala Glu Glu Glu Val Tyr Phe Ala 
65                  70                  75                  80  


Arg Arg Ala Leu Arg Gly Asp Val Ala Ser Arg Arg Arg Met Ile Glu 
                85                  90                  95      


Ser Asn Leu Arg Leu Val Val Lys Ile Ala Arg Arg Tyr Gly Asn Arg 
            100                 105                 110         


Gly Leu Ala Leu Leu Asp Leu Ile Glu Glu Gly Asn Leu Gly Leu Ile 
        115                 120                 125             


Arg Ala Val Glu Lys Phe Asp Pro Glu Arg Gly Phe Arg Phe Ser Thr 
    130                 135                 140                 


Tyr Ala Thr Trp Trp Ile Arg Gln Thr Ile Glu Arg Ala Ile Met Asn 
145                 150                 155                 160 


Gln Thr Arg Thr Ile Arg Leu Pro Ile His Ile Val Lys Glu Leu Asn 
                165                 170                 175     


Val Tyr Leu Arg Thr Ala Arg Glu Leu Ser His Lys Leu Asp His Glu 
            180                 185                 190         


Pro Ser Ala Glu Glu Ile Ala Glu Gln Leu Asp Lys Pro Val Asp Asp 
        195                 200                 205             


Val Ser Arg Met Leu Arg Leu Asn Glu Arg Ile Thr Ser Val Asp Thr 
    210                 215                 220                 


Pro Leu Gly Gly Asp Ser Glu Lys Ala Leu Leu Asp Ile Leu Ala Asp 
225                 230                 235                 240 


Glu Lys Glu Asn Gly Pro Glu Asp Thr Thr Gln Asp Asp Asp Met Lys 
                245                 250                 255     


Gln Ser Ile Val Lys Trp Leu Phe Glu Leu Asn Ala Lys Gln Arg Glu 
            260                 265                 270         


Val Leu Ala Arg Arg Phe Gly Leu Leu Gly Tyr Glu Ala Ala Thr Leu 
        275                 280                 285             


Glu Asp Val Gly Arg Glu Ile Gly Leu Thr Arg Glu Arg Val Arg Gln 
    290                 295                 300                 


Ile Gln Val Glu Gly Leu Arg Arg Leu Arg Glu Ile Leu Gln Thr Gln 
305                 310                 315                 320 


Gly Leu Asn Ile Glu Ala Leu Phe Arg Glu 
                325                 330 


<210>  11
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Thr Ala Glu Leu Leu Val Asn Val Thr Pro Ser Glu Thr Arg Val 
1               5                   10                  15      


Ala Tyr Ile Asp Gly Gly Ile Leu Gln Glu Ile His Ile Glu Arg Glu 
            20                  25                  30          


Ala Arg Arg Gly Ile Val Gly Asn Ile Tyr Lys Gly Arg Val Ser Arg 
        35                  40                  45              


Val Leu Pro Gly Met Gln Ala Ala Phe Val Asp Ile Gly Leu Asp Lys 
    50                  55                  60                  


Ala Ala Phe Leu His Ala Ser Asp Ile Met Pro His Thr Glu Cys Val 
65                  70                  75                  80  


Ala Gly Glu Glu Gln Lys Gln Phe Thr Val Arg Asp Ile Ser Glu Leu 
                85                  90                  95      


Val Arg Gln Gly Gln Asp Leu Met Val Gln Val Val Lys Asp Pro Leu 
            100                 105                 110         


Gly Thr Lys Gly Ala Arg Leu Thr Thr Asp Ile Thr Leu Pro Ser Arg 
        115                 120                 125             


Tyr Leu Val Phe Met Pro Gly Ala Ser His Val Gly Val Ser Gln Arg 
    130                 135                 140                 


Ile Glu Ser Glu Ser Glu Arg Glu Arg Leu Lys Lys Val Val Ala Glu 
145                 150                 155                 160 


Tyr Cys Asp Glu Gln Gly Gly Phe Ile Ile Arg Thr Ala Ala Glu Gly 
                165                 170                 175     


Val Gly Glu Ala Glu Leu Ala Ser Asp Ala Ala Tyr Leu Lys Arg Val 
            180                 185                 190         


Trp Thr Lys Val Met Glu Arg Lys Lys Arg Pro Gln Thr Arg Tyr Gln 
        195                 200                 205             


Leu Tyr Gly Glu Leu Ala Leu Ala Gln Arg Val Leu Arg Asp Phe Ala 
    210                 215                 220                 


Asp Ala Glu Leu Asp Arg Ile Arg Val Asp Ser Arg Leu Thr Tyr Glu 
225                 230                 235                 240 


Ala Leu Leu Glu Phe Thr Ser Glu Tyr Ile Pro Glu Met Thr Ser Lys 
                245                 250                 255     


Leu Glu His Tyr Thr Gly Arg Gln Pro Ile Phe Asp Leu Phe Asp Val 
            260                 265                 270         


Glu Asn Glu Ile Gln Arg Ala Leu Glu Arg Lys Val Glu Leu Lys Ser 
        275                 280                 285             


Gly Gly Tyr Leu Ile Ile Asp Gln Thr Glu Ala Met Thr Thr Val Asp 
    290                 295                 300                 


Ile Asn Thr Gly Ala Phe Val Gly His Arg Asn Leu Asp Asp Thr Ile 
305                 310                 315                 320 


Phe Asn Thr Asn Ile Glu Ala Thr Gln Ala Ile Ala Arg Gln Leu Arg 
                325                 330                 335     


Leu Arg Asn Leu Gly Gly Ile Ile Ile Ile Asp Phe Ile Asp Met Asn 
            340                 345                 350         


Asn Glu Asp His Arg Arg Arg Val Leu His Ser Leu Glu Gln Ala Leu 
        355                 360                 365             


Ser Lys Asp Arg Val Lys Thr Ser Val Asn Gly Phe Ser Ala Leu Gly 
    370                 375                 380                 


Leu Val Glu Met Thr Arg Lys Arg Thr Arg Glu Ser Ile Glu His Val 
385                 390                 395                 400 


Leu Cys Asn Glu Cys Pro Thr Cys His Gly Arg Gly Thr Val Lys Thr 
                405                 410                 415     


Val Glu Thr Val Cys Tyr Glu Ile Met Arg Glu Ile Val Arg Val His 
            420                 425                 430         


His Ala Tyr Asp Ser Asp Arg Phe Leu Val Tyr Ala Ser Pro Ala Val 
        435                 440                 445             


Ala Glu Ala Leu Lys Gly Glu Glu Ser His Ser Leu Ala Glu Val Glu 
    450                 455                 460                 


Ile Phe Val Gly Lys Gln Val Lys Val Gln Ile Glu Pro Leu Tyr Asn 
465                 470                 475                 480 


Gln Glu Gln Phe Asp Val Val Met Met 
                485                 


<210>  12
<211>  940
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Lys Met Ile Phe Thr Gly Lys Val Ser Gly Glu Lys Thr Val Leu 
1               5                   10                  15      


Thr Val Gly Gly Arg His Thr Val Lys Ala Gln Pro Gly Glu Gln Tyr 
            20                  25                  30          


Gly Leu Ile Asp Glu Val Thr Gly Leu Val Pro Asp Gly Val Glu Ala 
        35                  40                  45              


Asp Arg Ser Gly Asp Asp Leu Ile Leu Arg Lys Lys Glu Glu Asp Thr 
    50                  55                  60                  


Glu Val Arg Ile Glu Gly Phe Trp Glu Glu Cys Gln Pro Gly Glu Thr 
65                  70                  75                  80  


Gln Cys Thr Ala Val Phe Asn Ile Val Gly Glu Asp Gly Gln Val Thr 
                85                  90                  95      


Glu Ala Val Leu Thr Gln Asp Gly Pro Val Leu Asp Asp Ile Thr Ala 
            100                 105                 110         


Gly Gln Ser Gly Thr Leu Ser Asp Asp Asp Arg Gly Gly Phe Ile Trp 
        115                 120                 125             


Leu Gly Gly Leu Ala Phe Gly Gly Gly Leu Ala Ala Met Ala Leu Ala 
    130                 135                 140                 


Ala Gly Gly Gly Gly Ser Lys His Arg His Glu Asn Asp Asp Ser Asp 
145                 150                 155                 160 


Thr Thr Ala Pro Ser Ser Pro Ala Leu Lys Ala Glu Asp Asp Gly Ser 
                165                 170                 175     


Val Ser Val Glu Leu Pro Gly Asp Ala Asn Lys Gly Asp Thr Val Asp 
            180                 185                 190         


Val Thr Phe Glu Asp Glu Lys Gly Gly Lys His Thr Val Thr Leu Glu 
        195                 200                 205             


Lys Gly Asp Asn Gly Trp Thr Ser Ser Asp Pro Thr Leu Ile Pro Asp 
    210                 215                 220                 


Ser Thr Gly Asp Lys Ala Thr Ile Pro Ala Asp Asn Val Lys Asp Asn 
225                 230                 235                 240 


Ser Glu Val Thr Gly Val Ala Lys Asp Pro Ser Gly Asn Glu Ser Asp 
                245                 250                 255     


Pro Ser Thr Val Thr Ser Lys Thr Asp Val Leu Pro Thr Val Ser Ile 
            260                 265                 270         


Ser Val Glu Thr Thr Ser Thr Asp Val Asn Gly Asp Gly Phe Thr Gly 
        275                 280                 285             


Ile Ala Ser Val Asn Gly Thr Val Met Asp Val Pro Ala Thr Ile Glu 
    290                 295                 300                 


Asp Lys Asp Asp Ser Thr Gly Leu Val Tyr Thr Val Ser Leu Asn His 
305                 310                 315                 320 


Val Thr Thr Thr Asp Val Thr Val Thr Val Thr Leu Gly Ser Gly Ala 
                325                 330                 335     


Gly His Ser Asp Ala Ala Asp Tyr Ser Asp Ile Gly Gly Ala Gln His 
            340                 345                 350         


Asn Gly Lys Ile Gly Leu His Gly Asp Thr Gly Lys Val Thr Tyr Asp 
        355                 360                 365             


Gly Ala Thr Thr Val Thr Ile Val Ile Pro Ala Gly Ser Lys Ser Val 
    370                 375                 380                 


Ser Phe Ile Val Asp Pro Thr Leu Glu Ala Asn Gln Asp Ala Phe Asn 
385                 390                 395                 400 


Ala Glu Gly Met Glu Lys Val Val Ala Thr Ile Thr Gly Thr Ser Asp 
                405                 410                 415     


Asn Val Thr Ala Ala Thr Asp Ile Val Asp Asn Ala Gly Ala Ser Ala 
            420                 425                 430         


Thr Gly Val Ile Tyr Asp Gly Asn Ala Ile Ser Leu Arg Asn Leu Asp 
        435                 440                 445             


Gly Asp Phe Thr Leu Lys Tyr Ser Leu Ser Ser Ser Ile Ala Glu Lys 
    450                 455                 460                 


Gly Asp Phe Gly Tyr Thr Ile Gly Ala Asn Ser Gly Glu Asn Asp Pro 
465                 470                 475                 480 


Met Val Thr Thr Asp Tyr Asn Asp Thr Val Tyr Val Gly Tyr Tyr Gln 
                485                 490                 495     


Ser Gly Lys Glu Thr Thr Ser Tyr Ser Asn Val Ala Asn Ser Gln Asp 
            500                 505                 510         


Asn Gly Pro Asp Gly Thr Lys Thr Asp Gly Asn Gln Ser Ile Thr Thr 
        515                 520                 525             


Val Asp Leu Gly Ala Gly Asp Asp Leu Met Val Ile Arg Gly Asn Met 
    530                 535                 540                 


Leu Ala Asn Thr Arg Val Tyr Thr Gly Glu Gly Asn Asp Thr Phe Thr 
545                 550                 555                 560 


Met Asp Gly Met Asn Thr Ala Leu Arg Val Met Tyr Ala Gly Ser Tyr 
                565                 570                 575     


Ile Phe Thr Glu Ser Gly Asp Asp Ile Val Thr Ile Lys Arg Thr Gly 
            580                 585                 590         


Val Thr Asn Ala Gly Gln Ile Tyr Leu Gly Ser Gly Ser Asp Thr Phe 
        595                 600                 605             


Ile Gln Gly Asp Ala Thr Asp Asn Asn Asp Thr Thr Leu Ser Gly Leu 
    610                 615                 620                 


Leu Asp Leu Gly Ser Gly Thr Lys Asp Ile Ser Asn Met Pro Lys Glu 
625                 630                 635                 640 


Tyr Leu Ser Val Tyr Gln Asp Gly Ser Asn Leu Ser Leu Gly Asn Asp 
                645                 650                 655     


Asn Asn Ile Asp Thr Ala Thr Asp Val Asn Thr Val Thr Ile Tyr Gly 
            660                 665                 670         


Ser Val Ser Gly Glu Ile Leu Gly Gly Tyr Gly Ser Asp Asn Ile Thr 
        675                 680                 685             


Val Thr Lys Asn Leu Thr Gly Asn Ile Ser Val Gly Asp Asn Ala Asp 
    690                 695                 700                 


Thr Leu Thr Ala Gly Trp Ile Tyr Gly Gly Ser Thr Val Ser Met Gly 
705                 710                 715                 720 


Asp Gly Asn Asp Thr Val Thr Ile Thr Asp Gly Ala Tyr Asn Thr Thr 
                725                 730                 735     


Ile Ser Leu Gly Ala Gly Asp Asp Val Phe Asp Ala Thr Ser Gly Val 
            740                 745                 750         


Met Gly Asp Ser Ala Tyr Ala Thr Val Val Asn Gly Glu Asp Gly Asn 
        755                 760                 765             


Asp Thr Phe Lys Leu Gly Thr Ile Ala Lys Asn Leu Thr Ile Asp Ala 
    770                 775                 780                 


Gly Ala Gly Asp Asp Ile Val Val Leu Thr Lys Asp Tyr Asp Ser Thr 
785                 790                 795                 800 


Ser Ser Gly Asn Gln Gly Tyr Ile Asn Gly Gly Glu Gly Ser Asp Thr 
                805                 810                 815     


Leu Val Leu Thr Gly Thr Ile Ser Val Asn Leu Ala Ala Gly Lys Asn 
            820                 825                 830         


Glu Gly Ile Ala Gly Phe Glu Lys Val Asp Met Thr Val Gly Ser Asp 
        835                 840                 845             


Leu Lys Ala Asp Asn Ala Ala Gln Leu Val Lys Leu Thr Ala Ser Asp 
    850                 855                 860                 


Val Leu Gly Ile Asn Asp Asn Ser Thr Ile Tyr Ile Ser Gly Asp Ala 
865                 870                 875                 880 


Asn Asp Lys Val Asp Leu Gly Ala Asp Gly Ala Gly Ser Leu Gly Thr 
                885                 890                 895     


Phe Thr Ala Thr Ala Thr Thr Val Lys Ala Thr Ala Leu Asp Gly Ile 
            900                 905                 910         


Glu His Thr Tyr Thr Leu Tyr Ser Ser Val Ser Gly Ala Asn Val Tyr 
        915                 920                 925             


Ile Asp Asn Asn Ile Ile Asp Ala Asn Gly Val Ile 
    930                 935                 940 


<210>  13
<211>  886
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Ser Gln Arg Gly Leu Glu Ala Leu Leu Arg Pro Lys Ser Ile Ala 
1               5                   10                  15      


Val Ile Gly Ala Ser Met Lys Pro Asn Arg Ala Gly Tyr Leu Met Met 
            20                  25                  30          


Arg Asn Leu Leu Ala Gly Gly Phe Asn Gly Pro Val Leu Pro Val Thr 
        35                  40                  45              


Pro Ala Trp Lys Ala Val Leu Gly Val Leu Ala Trp Pro Asp Ile Ala 
    50                  55                  60                  


Ser Leu Pro Phe Thr Pro Asp Leu Ala Val Leu Cys Thr Asn Ala Ser 
65                  70                  75                  80  


Arg Asn Leu Ala Leu Leu Glu Glu Leu Gly Glu Lys Gly Cys Lys Thr 
                85                  90                  95      


Cys Ile Ile Leu Ser Ala Pro Ala Ser Gln His Glu Asp Leu Arg Ala 
            100                 105                 110         


Cys Ala Leu Arg His Asn Met Arg Leu Leu Gly Pro Asn Ser Leu Gly 
        115                 120                 125             


Leu Leu Ala Pro Trp Gln Gly Leu Asn Ala Ser Phe Ser Pro Val Pro 
    130                 135                 140                 


Ile Lys Arg Gly Lys Leu Ala Phe Ile Ser Gln Ser Ala Ala Val Ser 
145                 150                 155                 160 


Asn Thr Ile Leu Asp Trp Ala Gln Gln Arg Lys Met Gly Phe Ser Tyr 
                165                 170                 175     


Phe Ile Ala Leu Gly Asp Ser Leu Asp Ile Asp Val Asp Glu Leu Leu 
            180                 185                 190         


Asp Tyr Leu Ala Arg Asp Ser Lys Thr Ser Ala Ile Leu Leu Tyr Leu 
        195                 200                 205             


Glu Gln Leu Ser Asp Ala Arg Arg Phe Val Ser Ala Ala Arg Ser Ala 
    210                 215                 220                 


Ser Arg Asn Lys Pro Ile Leu Val Ile Lys Ser Gly Arg Ser Pro Ala 
225                 230                 235                 240 


Ala Gln Arg Leu Leu Asn Thr Thr Ala Gly Met Asp Pro Ala Trp Asp 
                245                 250                 255     


Ala Ala Ile Gln Arg Ala Gly Leu Leu Arg Val Gln Asp Thr His Glu 
            260                 265                 270         


Leu Phe Ser Ala Val Glu Thr Leu Ser His Met Arg Pro Leu Arg Gly 
        275                 280                 285             


Asp Arg Leu Met Ile Ile Ser Asn Gly Ala Ala Pro Ala Ala Leu Ala 
    290                 295                 300                 


Leu Asp Ala Leu Trp Ser Arg Asn Gly Lys Leu Ala Thr Leu Ser Glu 
305                 310                 315                 320 


Glu Thr Cys Gln Lys Leu Arg Asp Ala Leu Pro Glu His Val Ala Ile 
                325                 330                 335     


Ser Asn Pro Leu Asp Leu Arg Asp Asp Ala Ser Ser Glu His Tyr Ile 
            340                 345                 350         


Lys Thr Leu Asp Ile Leu Leu His Ser Gln Asp Phe Asp Ala Leu Met 
        355                 360                 365             


Val Ile His Ser Pro Ser Ala Ala Ala Pro Ala Thr Glu Ser Ala Gln 
    370                 375                 380                 


Val Leu Ile Glu Ala Val Lys His His Pro Arg Ser Lys Tyr Val Ser 
385                 390                 395                 400 


Leu Leu Thr Asn Trp Cys Gly Glu His Ser Ser Gln Glu Ala Arg Arg 
                405                 410                 415     


Leu Phe Ser Glu Ala Gly Leu Pro Thr Tyr Arg Thr Pro Glu Gly Thr 
            420                 425                 430         


Ile Thr Ala Phe Met His Met Val Glu Tyr Arg Arg Asn Gln Lys Gln 
        435                 440                 445             


Leu Arg Glu Thr Pro Ala Leu Pro Ser Asn Leu Thr Ser Asn Thr Ala 
    450                 455                 460                 


Glu Ala His Leu Leu Leu Gln Gln Ala Ile Ala Glu Gly Ala Thr Ser 
465                 470                 475                 480 


Leu Asp Thr His Glu Val Gln Pro Ile Leu Gln Ala Tyr Gly Met Asn 
                485                 490                 495     


Thr Leu Pro Thr Trp Ile Ala Ser Asp Ser Thr Glu Ala Val His Ile 
            500                 505                 510         


Ala Glu Gln Ile Gly Tyr Pro Val Ala Leu Lys Leu Arg Ser Pro Asp 
        515                 520                 525             


Ile Pro His Lys Ser Glu Val Gln Gly Val Met Leu Tyr Leu Arg Thr 
    530                 535                 540                 


Ala Asn Glu Val Gln Gln Ala Ala Asn Ala Ile Phe Asp Arg Val Lys 
545                 550                 555                 560 


Met Ala Trp Pro Gln Ala Arg Val His Gly Leu Leu Val Gln Ser Met 
                565                 570                 575     


Ala Asn Arg Ala Gly Ala Gln Glu Leu Arg Val Val Val Glu His Asp 
            580                 585                 590         


Pro Val Phe Gly Pro Leu Ile Met Leu Gly Glu Gly Gly Val Glu Trp 
        595                 600                 605             


Arg Pro Glu Asp Gln Ala Val Val Ala Leu Pro Pro Leu Asn Met Asn 
    610                 615                 620                 


Leu Ala Arg Tyr Leu Val Ile Gln Gly Ile Lys Ser Lys Lys Ile Arg 
625                 630                 635                 640 


Ala Arg Ser Ala Leu Arg Pro Leu Asp Val Ala Gly Leu Ser Gln Leu 
                645                 650                 655     


Leu Val Gln Val Ser Asn Leu Ile Val Asp Cys Pro Glu Ile Gln Arg 
            660                 665                 670         


Leu Asp Ile His Pro Leu Leu Ala Ser Gly Ser Glu Phe Thr Ala Leu 
        675                 680                 685             


Asp Val Thr Leu Asp Ile Ser Pro Phe Glu Gly Asp Asn Glu Ser Arg 
    690                 695                 700                 


Leu Ala Val Arg Pro Tyr Pro His Gln Leu Glu Glu Trp Val Glu Leu 
705                 710                 715                 720 


Lys Asn Gly Glu Arg Cys Leu Phe Arg Pro Ile Leu Pro Glu Asp Glu 
                725                 730                 735     


Pro Gln Leu Gln Gln Phe Ile Ser Arg Val Thr Lys Glu Asp Leu Tyr 
            740                 745                 750         


Tyr Arg Tyr Phe Ser Glu Ile Asn Glu Phe Thr His Glu Asp Leu Ala 
        755                 760                 765             


Asn Met Thr Gln Ile Asp Tyr Asp Arg Glu Met Ala Phe Val Ala Val 
    770                 775                 780                 


Arg Arg Ile Asp Gln Thr Glu Glu Ile Leu Gly Val Thr Arg Ala Ile 
785                 790                 795                 800 


Ser Asp Pro Asp Asn Ile Asp Ala Glu Phe Ala Val Leu Val Arg Ser 
                805                 810                 815     


Asp Leu Lys Gly Leu Gly Leu Gly Arg Arg Leu Met Glu Lys Leu Ile 
            820                 825                 830         


Thr Tyr Thr Arg Asp His Gly Leu Gln Arg Leu Asn Gly Ile Thr Met 
        835                 840                 845             


Pro Asn Asn Arg Gly Met Val Ala Leu Ala Arg Lys Leu Gly Phe Asn 
    850                 855                 860                 


Val Asp Ile Gln Leu Glu Glu Gly Ile Val Gly Leu Thr Leu Asn Leu 
865                 870                 875                 880 


Ala Gln Arg Glu Glu Ser 
                885     


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Asn Gln Gln Asp Ile Glu Gln Val Leu Lys Ala Val Gln Leu Lys 
1               5                   10                  15      


Met Gln Ser Ser 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Glu Ile Asn Glu Lys Leu Leu Arg Gln Ile Ile Glu Asp Val Leu 
1               5                   10                  15      


Arg Asp Met Lys 
            20  


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Asn Thr Ser Glu Leu Glu Thr Leu Ile Arg Thr Ile Leu Ser Glu 
1               5                   10                  15      


Gln Leu 
        


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Asn Gln Gln Asp Ile Glu Gln Val Val Lys Ala Val Leu Leu Lys 
1               5                   10                  15      


Met Lys 
        


<210>  18
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Asn Gln Gln Asp Ile Glu Gln Val Leu Lys Ala Val Leu Leu Lys 
1               5                   10                  15      


Met Lys 
        


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Asn Gln Gln Asp Ile Glu Gln Val Val Lys Ala Val Gln Leu Lys 
1               5                   10                  15      


Met Lys 
        


<210>  20
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
tagagataat aactctaatg tttaaaatct tttagtaaat aacagtgagt atgagcgcga       60

g                                                                       61


