                               SEQUENCE LISTING

<110> SAREPTA THERAPEUTICS, INC.
      CHANDA, ARANI
      DILUZIO, WILLOW
      SANE, POOJA
      NAIK, SHIVANGA

 
<120> COMPOSITIONS COMPRISING EXON SKIPPING OLIGONUCLEOTIDE CONJUGATES 
      FOR TREATING MUSCULAR DYSTROPHY

<130> 8169.51.WO00

<140>
<141>

<150> 63/129,752
<151> 2020-12-23

<160> 60    

<170> PatentIn version 3.5

<210> 1
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1
ctccaacatc aaggaagatg gcatttctag                                        30


<210> 2
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 2
acctccaaca tcaaggaaga tggc                                              24


<210> 3
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 3
gtacctccaa catcaaggaa gatggcattt                                        30


<210> 4
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 4
gtacctccaa catcaaggaa gatggcat                                          28


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 5
tcaaggaaga tggcatttct                                                   20


<210> 6
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 6
ucaaggaaga uggcauuucu                                                   20


<210> 7
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 7
gttgcctccg gttctgaagg tgttc                                             25


<210> 8
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 8
gttgcctccg gttctgaagg tgttc                                             25


<210> 9
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 9
cctccggttc tgaaggtgtt c                                                 21


<210> 10
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
ctgaaggtgt tcttgtactt catcc                                             25


<210> 11
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 11
cctccggttc tgaaggtgtt cttgt                                             25


<210> 12
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
gttgcctccg gttctgaagg tgttcttg                                          28


<210> 13
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
ttgcctccgg ttctgaaggt gttcttgtac                                        30


<210> 14
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 14
ctgttgcctc cggttctgaa ggtg                                              24


<210> 15
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 15
cattcaactg ttgcctccgg ttctgaaggt g                                      31


<210> 16
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 16
ctgttgcctc cggttctg                                                     18


<210> 17
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 17
caatgccatc ctggagttcc tg                                                22


<210> 18
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 18
gctgcccaat gccatcctgg agttcctgta agat                                   34


<210> 19
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 19
gctgcccaat gccatcctgg agttcctg                                          28


<210> 20
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 20
gctgcccaat gccatcctgg agttcctgta a                                      31


<210> 21
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 21
caatgccatc ctggagttcc tgtaagatac c                                      31


<210> 22
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 22
caatgccatc ctggagttcc tgtaagat                                          28


<210> 23
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 23
tgccatcctg gagttcctgt aagatacc                                          28


<210> 24
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 24
gctgcccaat gccatcctgg agttcctgta agataccaa                              39


<210> 25
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 25
caatgccatc ctggagttcc tgtaaga                                           27


<210> 26
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 26
gctgcccaat gccatcctgg agttcctgta ag                                     32


<210> 27
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 27
gcccaatgcc atcctggagt tcctgtaaga tacc                                   34


<210> 28
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 28
gcccaatgcc atcctggagt tcctgtaaga t                                      31


<210> 29
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 29
ttgccgctgc ccaatgccat cctggagttc ctgtaagat                              39


<210> 30
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 30
gcccaatgcc atcctggagt tcctgtaa                                          28


<210> 31
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 31
gccgctgccc aatgccatcc tggagttcct gtaa                                   34


<210> 32
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 32
gcccaatgcc atcctggagt tcctg                                             25


<210> 33
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 33
gccgctgccc aatgccatcc tggagttcct g                                      31


<210> 34
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 34
cgctgcccaa tgccaucc                                                     18


<210> 35
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 35
gatctgtcaa atcgcctgca ggtaa                                             25


<210> 36
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 36
gatctgtcaa atcgcctgca gg                                                22


<210> 37
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 37
cagatctgtc aaatcgcctg cagg                                              24


<210> 38
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 38
gatctgtcaa atcgcctgca ggt                                               23


<210> 39
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 39
gatctgtcaa atcgcctgca g                                                 21


<210> 40
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 40
cagatctgtc aaatcgcctg caggt                                             25


<210> 41
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 41
cagatctgtc aaatcgcctg cag                                               23


<210> 42
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 42
gggatccagt atacttacag gc                                                22


<210> 43
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 43
gggatccagt atacttacag gctcc                                             25


<210> 44
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 44
gatccagtat acttacaggc tcc                                               23


<210> 45
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 45
ggatccagta tacttacagg ctcc                                              24


<210> 46
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 46
acttcctctt taacagaaaa gcatac                                            26


<210> 47
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 47
atccagtata cttacaggct cc                                                22


<210> 48
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 48
gagctcagat cttctaactt cctct                                             25


<210> 49
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 49
gggatccagt atacttacag gctc                                              24


<210> 50
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 50
atgggatcca gtatacttac aggctcc                                           27


<210> 51
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 51
ctgttccaaa tcctgcattg ttgcc                                             25


<210> 52
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Arg Arg Arg Arg Arg Arg Gly 
1               5           


<210> 53
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Arg Arg Arg Arg Arg Arg 
1               5       


<210> 54
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> 6-aminohexanoic acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> 6-aminohexanoic acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> 6-aminohexanoic acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> 6-aminohexanoic acid

<400> 54
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg 
1               5                   10          


<210> 55
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Arg Phe Phe Arg Phe Phe Arg Phe Phe Arg 
1               5                   10  


<210> 56
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> 6-aminohexanoic acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> 6-aminohexanoic acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> 6-aminohexanoic acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> 6-aminohexanoic acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> 6-aminohexanoic acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Beta-alanine

<400> 56
Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa Xaa 
1               5                   10                  


<210> 57
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (11)..(11)
<223> 6-aminohexanoic acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Beta-alanine

<400> 57
Arg Phe Phe Arg Phe Phe Arg Phe Phe Arg Xaa Xaa 
1               5                   10          


<210> 58
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Arg Phe Phe Arg Phe Phe Arg Phe Phe Arg Gly 
1               5                   10      


<210> 59
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Arg Arg Arg Arg Arg Gly 
1               5       


<210> 60
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Arg Arg Arg Arg Arg 
1               5   


