                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  METHODS FOR OBTAINING ANTIBODIES THAT BIND TRANSMEMBRANE PROTEINS
       AND CELLS THAT PRODUCE THE SAME

<130>  36526 (10465WO01)

<150>  63/130,044
<151>  2020-12-23

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  1

Met Gly His His His His His His Ile Glu Gly Arg 
1               5                   10          


<210>  2
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  2

Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys 
1               5                   10                  15      


Leu Arg Glu Gln Leu Gly 
            20          


<210>  3
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  3

Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly 
1               5                   10                  15      


Leu Arg Gln Glu Met Ser 
            20          


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  4

Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln 
1               5                   10      


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  5

Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu 
1               5                   10                  15      


Tyr Arg Gln Lys Val Glu 
            20          


<210>  6
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  6

Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
1               5                   10                  15      


Leu Gln Glu Lys Leu Ser 
            20          


<210>  7
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  7

Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala 
1               5                   10                  15      


Leu Arg Thr His Leu Ala 
            20          


<210>  8
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  8

Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala 
1               5                   10                  15      


Leu Lys Glu Asn Gly Gly 
            20          


<210>  9
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  9

Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr 
1               5                   10                  15      


Leu Ser Glu Lys Ala Lys 
            20          


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  10

Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu 
1               5                   10      


<210>  11
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  11

Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu 
1               5                   10                  15      


Tyr Thr Lys Lys Leu Asn Thr Gln 
            20                  


<210>  12
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  12

Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 
1               5                   10                  15      


Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 
        115                 120                 125             


Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 
    130                 135                 140                 


Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 
145                 150                 155                 160 


Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 
                165                 170                 175     


Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 
            180                 185                 190         


Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 
        195                 200                 205             


Leu Asn Thr Gln 
    210         


<210>  13
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  13

Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 
1               5                   10                  15      


Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 
        115                 120                 125             


Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 
    130                 135                 140                 


Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 
145                 150                 155                 160 


Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 
                165                 170                 175     


Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 
            180                 185                 190         


Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 
        195                 200                 205             


Leu Asn Thr Gln Gly Thr Leu Lys Leu Leu Asp Asn Trp Asp Ser Val 
    210                 215                 220                 


Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln 
225                 230                 235                 240 


Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu 
                245                 250                 255     


Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu 
            260                 265                 270         


Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln 
        275                 280                 285             


Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys 
    290                 295                 300                 


Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg 
305                 310                 315                 320 


Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro 
                325                 330                 335     


Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu 
            340                 345                 350         


Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr 
        355                 360                 365             


Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp 
    370                 375                 380                 


Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe 
385                 390                 395                 400 


Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
                405                 410                 


<210>  14
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  14

Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 
1               5                   10                  15      


Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Tyr Leu Asp Asp Phe Gln 
                85                  90                  95      


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
            100                 105                 110         


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
        115                 120                 125             


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
    130                 135                 140                 


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
145                 150                 155                 160 


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
                165                 170                 175     


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
            180                 185                 190         


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
        195                 200                 205             


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
    210                 215                 220                 


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
225                 230                 


<210>  15
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  15

Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 
1               5                   10                  15      


Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr 
        115                 120                 125             


Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg 
    130                 135                 140                 


Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu 
145                 150                 155                 160 


Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu 
                165                 170                 175     


Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu 
            180                 185                 190         


Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys 
        195                 200                 205             


Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu 
    210                 215                 220                 


Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val 
225                 230                 235                 240 


Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
                245                 250                 255     


<210>  16
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  16

Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 
1               5                   10                  15      


Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 
        115                 120                 125             


Arg Thr His Leu Ala Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln 
    130                 135                 140                 


Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu 
145                 150                 155                 160 


Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu 
                165                 170                 175     


Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp 
            180                 185                 190         


Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg 
        195                 200                 205             


Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu 
    210                 215                 220                 


Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu 
225                 230                 235                 240 


Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val 
                245                 250                 255     


Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr 
            260                 265                 270         


Lys Lys Leu Asn Thr Gln 
        275             


<210>  17
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  17

Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 
        115                 120                 125             


Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 
    130                 135                 140                 


Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 
145                 150                 155                 160 


Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 
                165                 170                 175     


Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 
            180                 185                 190         


Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 
        195                 200                 205             


Leu Asn Thr Gln 
    210         


<210>  18
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  18

Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly 
            20              


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  19

Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly 
1               5                   10      


<210>  20
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  20

Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Pro Val Thr Gln Glu Phe Trp Asp Asn 
            20                  25                  30          


Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu 
        35                  40                  45              


Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys 
    50                  55                  60                  


Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu 
65                  70                  75                  80  


Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln 
                85                  90                  95      


Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala 
            100                 105                 110         


His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu 
        115                 120                 125             


Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly 
    130                 135                 140                 


Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr 
145                 150                 155                 160 


Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu 
                165                 170                 175     


Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu 
            180                 185                 190         


Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
        195                 200     


<210>  21
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  21

Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 
        115                 120                 125             


Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 
    130                 135                 140                 


Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 
145                 150                 155                 160 


Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 
                165                 170                 175     


Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 
            180                 185                 190         


Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 
        195                 200                 205             


Leu Asn Thr Gln Gly Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    210                 215                 220                 


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
225                 230                 235                 240 


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                245                 250                 255     


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            260                 265                 270         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        275                 280                 285             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    290                 295                 300                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
305                 310                 315                 320 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                325                 330                 335     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            340                 345                 350         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        355                 360                 365             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    370                 375                 380                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
385                 390                 395                 400 


Asn Thr Gln 
            


<210>  22
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  22

Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 
        115                 120                 125             


Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 
    130                 135                 140                 


Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 
145                 150                 155                 160 


Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 
                165                 170                 175     


Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 
            180                 185                 190         


Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 
        195                 200                 205             


Leu Asn Thr Gln Gly Thr Pro Val Thr Gln Glu Phe Trp Asp Asn Leu 
    210                 215                 220                 


Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu 
225                 230                 235                 240 


Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys 
                245                 250                 255     


Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg 
            260                 265                 270         


Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu 
        275                 280                 285             


Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His 
    290                 295                 300                 


Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg 
305                 310                 315                 320 


Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala 
                325                 330                 335     


Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu 
            340                 345                 350         


Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu 
        355                 360                 365             


Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu 
    370                 375                 380                 


Tyr Thr Lys Lys Leu Asn Thr Gln 
385                 390         


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  23

Arg Glu Gln Leu Gly 
1               5   


<210>  24
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  24

Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 
        115                 120                 125             


Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 
    130                 135                 140                 


Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 
145                 150                 155                 160 


Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 
                165                 170                 175     


Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 
            180                 185                 190         


Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 
        195                 200                 205             


Leu Asn Thr Gln Gly Thr Arg Glu Gln Leu Gly Pro Val Thr Gln Glu 
    210                 215                 220                 


Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met 
225                 230                 235                 240 


Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp 
                245                 250                 255     


Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys 
            260                 265                 270         


Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu 
        275                 280                 285             


His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp 
    290                 295                 300                 


Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr 
305                 310                 315                 320 


Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys 
                325                 330                 335     


Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu 
            340                 345                 350         


His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu 
        355                 360                 365             


Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu 
    370                 375                 380                 


Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
385                 390                 395         


