                         SEQUENCE LISTING

<110>  University of Kentucky Research Foundation
 
<120>  STRUCTURE-BASED DESIGN AND DISCOVERY OF LONG-ACTING COCAINE 
       HYDROLASE MUTANTS WITH IMPROVED BINDING AFFINITY TO NEONATAL FC 
       RECEPTOR FOR TREATMENT OF SUBSTANCE USE DISORDERS AND 
       ORGANOPHOSPHORUS TOXICITY

<130>  13177N/2517US

<150>  63/128,774
<151>  2020-12-21

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  1

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Phe Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Leu Glu Met Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys 
    530                 535                 540                 


Ala Gly Phe His Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln 
545                 550                 555                 560 


Phe Asn Asp Tyr Thr Ser Lys Lys Glu Ser Cys Val Gly Leu 
                565                 570                 


<210>  2
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  2

Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  3
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  3

Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  4
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  4

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ser Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Ala Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Gly Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Trp Phe Leu Val Gly Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Gly Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Leu Glu Met Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys 
    530                 535                 540                 


Ala Gly Phe His Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln 
545                 550                 555                 560 


Phe Asn Asp Tyr Thr Ser Lys Lys Glu Ser Cys Val Gly Leu 
                565                 570                 


<210>  5
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  5

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ser Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Ala Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Ala Leu Gly Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Trp Phe Leu Val Gly Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Gly Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Leu Glu Met Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys 
    530                 535                 540                 


Ala Gly Phe His Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln 
545                 550                 555                 560 


Phe Asn Asp Tyr Thr Ser Lys Lys Glu Ser Cys Val Gly Leu 
                565                 570                 


<210>  6
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  6

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  7
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  7

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  8
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  8

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Tyr Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  9
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  9

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ser Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Ala Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Gly Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Trp Phe Leu Val Gly Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            660                 665                 670         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  10
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  10

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ser Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Ala Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Gly Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Trp Phe Leu Val Gly Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            660                 665                 670         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  11
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  11

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ser Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Ala Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Gly Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Trp Phe Leu Val Gly Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            660                 665                 670         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  12
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  12

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ser Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Ala Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Gly Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Trp Phe Leu Val Gly Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Tyr Ile Ser Arg Thr Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            660                 665                 670         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  13
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  13

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ser Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Ala Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Gly Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Trp Phe Leu Val Gly Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Gly Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            660                 665                 670         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  14
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  14

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ser Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Ala Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Ala Leu Gly Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Trp Phe Leu Val Gly Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Gly Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            660                 665                 670         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  15
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  15

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ser Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Ala Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Ala Leu Gly Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Trp Phe Leu Val Gly Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Gly Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Tyr Ile Ser Arg Thr Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            660                 665                 670         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  16
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  16

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ser Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Ala Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Ala Leu Gly Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Trp Phe Leu Val Gly Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Gly Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            660                 665                 670         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  17
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  17

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Phe Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            660                 665                 670         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  18
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  18

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Phe Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Tyr Ile Ser Arg Thr Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            660                 665                 670         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  19
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  19

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
1               5                   10                  15      


Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
            20                  25                  30          


Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
        35                  40                  45              


Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
    50                  55                  60                  


Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
65                  70                  75                  80  


Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
                85                  90                  95      


Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
            100                 105                 110         


Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
        115                 120                 125             


Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
    130                 135                 140                 


Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
145                 150                 155                 160 


Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
                165                 170                 175     


Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
            180                 185                 190         


Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu 
        195                 200                 205             


Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
    210                 215                 220                 


Gly Ser Phe Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
225                 230                 235                 240 


Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
                245                 250                 255     


Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
            260                 265                 270         


Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val 
        275                 280                 285             


Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
    290                 295                 300                 


Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
305                 310                 315                 320 


Val Asn Lys Asp Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly 
                325                 330                 335     


Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
            340                 345                 350         


Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
        355                 360                 365             


Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
    370                 375                 380                 


Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
                405                 410                 415     


Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
            420                 425                 430         


Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
        435                 440                 445             


Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
    450                 455                 460                 


Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
465                 470                 475                 480 


Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
                485                 490                 495     


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
            500                 505                 510         


Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys 
        515                 520                 525             


Val Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            660                 665                 670         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  20
<211>  1722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  20
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagtgcagga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttcctt taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctcctttgtc agtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac agctttttta gtctatggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctggacat cattttttcc aaaagtcttg gaaatgacag gaaatattga tgaagcagaa     1620

tgggagtgga aagcaggatt ccatcgctgg aacaattaca tgatggactg gaaaaatcaa     1680

tttaacgatt acactagcaa gaaagaaagt tgtgtgggtc tc                        1722


<210>  21
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  21
gcagagccta agtcctgcga caaaactcac acatgcccac cgtgcccagc acctgaactc       60

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      120

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      180

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      240

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      300

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa      360

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      420

cgggacgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc      480

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      540

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag      600

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcacgaggc tctgcacaac      660

cactacacgc agaagagcct ctccctgtct ccgggtaaa                             699


<210>  22
<211>  1722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  22
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagttccgga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttccgc taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctcctttggg tgtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac atggttttta gtcggtggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctggacat cattttttcc aaaagtcttg gaaatgacag gaaatattga tgaagcagaa     1620

tgggagtgga aagcaggatt ccatcgctgg aacaattaca tgatggactg gaaaaatcaa     1680

tttaacgatt acactagcaa gaaagaaagt tgtgtgggtc tc                        1722


<210>  23
<211>  1722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  23
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagttccgga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttccgc taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctcctttggg tgtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac atggttttta gtcggtggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctgggctt cattttttcc aaaagtcttg gaaatgacag gaaatattga tgaagcagaa     1620

tgggagtgga aagcaggatt ccatcgctgg aacaattaca tgatggactg gaaaaatcaa     1680

tttaacgatt acactagcaa gaaagaaagt tgtgtgggtc tc                        1722


<210>  24
<211>  1722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  24
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagttccgga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttccgc taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctgctttggg tgtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac atggttttta gtcggtggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctgggctt cattttttcc aaaagtcttg gaaatgacag gaaatattga tgaagcagaa     1620

tgggagtgga aagcaggatt ccatcgctgg aacaattaca tgatggactg gaaaaatcaa     1680

tttaacgatt acactagcaa gaaagaaagt tgtgtgggtc tc                        1722


<210>  25
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  25
gtggagccta agtcctgcga caaaactcac acatgcccac cgtgcccagc acctgaactc       60

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct ctatatcacc      120

cgggaacctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      180

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      240

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      300

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa      360

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      420

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc      480

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      540

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag      600

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcacgaggc tctgcacaac      660

cactacacgc agaagagcct ctccctgtct ccgggtaaa                             699


<210>  26
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  26
gtggagccta agtcctgcga caaaactcac acatgcccac cgtgcccagc acctgaactc       60

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      120

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      180

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      240

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      300

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa      360

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      420

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc      480

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      540

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag      600

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcacgaggc tctgcacaac      660

cactacacgc agaagagcct ctccctgtct ccgggtaaa                             699


<210>  27
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  27
gtggagccta agtcctgcga caaaactcac acatgcccac cgtgcccagc acctgaactc       60

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct ctatatctcc      120

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      180

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      240

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      300

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa      360

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      420

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc      480

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      540

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag      600

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcacgaggc tctgcacaac      660

cactacacgc agaagagcct ctccctgtct ccgggtaaa                             699


<210>  28
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  28
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagttccgga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttccgc taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctcctttggg tgtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac atggttttta gtcggtggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctggacat cattttttcc aaaagtcgca gagcctaagt cctgcgacaa aactcacaca     1620

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1680

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1740

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1800

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1860

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1920

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1980

ccacaggtgt acaccctgcc cccatcccgg gacgagctga ccaagaacca ggtcagcctg     2040

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2100

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2160

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2220

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2280

ggtaaa                                                                2286


<210>  29
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  29
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagttccgga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttccgc taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctcctttggg tgtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac atggttttta gtcggtggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctggacat cattttttcc aaaagtcgtg gagcctaagt cctgcgacaa aactcacaca     1620

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1680

aaacccaagg acaccctcta tatcacccgg gaacctgagg tcacatgcgt ggtggtggac     1740

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1800

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1860

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1920

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1980

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     2040

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2100

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2160

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2220

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2280

ggtaaa                                                                2286


<210>  30
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  30
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagttccgga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttccgc taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctcctttggg tgtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac atggttttta gtcggtggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctggacat cattttttcc aaaagtcgtg gagcctaagt cctgcgacaa aactcacaca     1620

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1680

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1740

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1800

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1860

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1920

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1980

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     2040

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2100

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2160

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2220

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2280

ggtaaa                                                                2286


<210>  31
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  31
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagttccgga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttccgc taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctcctttggg tgtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac atggttttta gtcggtggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctggacat cattttttcc aaaagtcgtg gagcctaagt cctgcgacaa aactcacaca     1620

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1680

aaacccaagg acaccctcta tatctcccgg acccctgagg tcacatgcgt ggtggtggac     1740

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1800

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1860

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1920

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1980

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     2040

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2100

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2160

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2220

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2280

ggtaaa                                                                2286


<210>  32
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  32
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagttccgga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttccgc taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctcctttggg tgtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac atggttttta gtcggtggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctgggctt cattttttcc aaaagtcgtg gagcctaagt cctgcgacaa aactcacaca     1620

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1680

aaacccaagg acaccctcta tatcacccgg gaacctgagg tcacatgcgt ggtggtggac     1740

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1800

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1860

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1920

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1980

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     2040

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2100

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2160

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2220

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2280

ggtaaa                                                                2286


<210>  33
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  33
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagttccgga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttccgc taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctgctttggg tgtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac atggttttta gtcggtggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctgggctt cattttttcc aaaagtcgtg gagcctaagt cctgcgacaa aactcacaca     1620

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1680

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1740

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1800

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1860

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1920

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1980

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     2040

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2100

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2160

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2220

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2280

ggtaaa                                                                2286


<210>  34
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  34
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagttccgga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttccgc taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctgctttggg tgtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac atggttttta gtcggtggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctgggctt cattttttcc aaaagtcgtg gagcctaagt cctgcgacaa aactcacaca     1620

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1680

aaacccaagg acaccctcta tatctcccgg acccctgagg tcacatgcgt ggtggtggac     1740

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1800

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1860

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1920

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1980

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     2040

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2100

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2160

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2220

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2280

ggtaaa                                                                2286


<210>  35
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  35
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagttccgga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttccgc taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctgctttggg tgtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac atggttttta gtcggtggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctgggctt cattttttcc aaaagtcgtg gagcctaagt cctgcgacaa aactcacaca     1620

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1680

aaacccaagg acaccctcta tatcacccgg gaacctgagg tcacatgcgt ggtggtggac     1740

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1800

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1860

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1920

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1980

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     2040

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2100

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2160

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2220

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2280

ggtaaa                                                                2286


<210>  36
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  36
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagtgcagga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttcctt taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctcctttgtc agtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac agctttttta gtctatggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctggacat cattttttcc aaaagtcgtg gagcctaagt cctgcgacaa aactcacaca     1620

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1680

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1740

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1800

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1860

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1920

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1980

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     2040

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2100

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2160

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2220

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2280

ggtaaa                                                                2286


<210>  37
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  37
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagtgcagga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttcctt taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctcctttgtc agtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac agctttttta gtctatggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctggacat cattttttcc aaaagtcgtg gagcctaagt cctgcgacaa aactcacaca     1620

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1680

aaacccaagg acaccctcta tatctcccgg acccctgagg tcacatgcgt ggtggtggac     1740

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1800

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1860

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1920

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1980

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     2040

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2100

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2160

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2220

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2280

ggtaaa                                                                2286


<210>  38
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant

<400>  38
gaagatgaca tcataattgc aacaaagaat ggaaaagtca gagggatgaa cttgacagtt       60

tttggtggca cggtaacagc ctttcttgga attccctatg cacagccacc tcttggtaga      120

cttcgattca aaaagccaca gtctctgacc aagtggtctg atatttggaa tgccacaaaa      180

tatgcaaatt cttgctgtca gaacatagat caaagttttc caggcttcca tggatcagag      240

atgtggaacc caaacactga cctcagtgaa gactgtttat atctaaatgt atggattcca      300

gcacctaaac caaaaaatgc cactgtattg atatggattt atggtggtgg ttttcaaact      360

ggaacatcat ctttacatgt ttatgatggc aagtttctgg ctcgggttga aagagttatt      420

gtagtgtcaa tgaactatag ggtgggtgcc ctaggattct tagctttgcc aggaaatcct      480

gaggctccag ggaacatggg tttatttgat caacagttgg ctcttcagtg ggttcaaaaa      540

aatatagcag cctttggtgg aaatcctaaa agtgtaactc tctttggaga aagtgcagga      600

gcagcttcag ttagcctgca tttgctttct cctggaagcc attcattgtt caccagagcc      660

attctgcaaa gtggttcctt taatgctcct tgggcggtaa catctcttta tgaagctagg      720

aacagaacgt tgaacttagc taaattgact ggttgctcta gagagaatga gactgaaata      780

atcaagtgtc ttagaaataa agatccccaa gaaattcttc tgaatgaagc atttgttgtc      840

ccctatggga ctcctttgtc agtaaacttt ggtccgaccg tggatggtga ttttctcact      900

gacatgccag acatattact tgaacttgga caatttaaaa aaacccagat tttggtgggt      960

gttaataaag atgaagggac agctttttta gtctatggtg ctcctggctt cagcaaagat     1020

aacaatagta tcataactag aaaagaattt caggaaggtt taaaaatatt ttttccagga     1080

gtgagtgagt ttggaaagga atccatcctt tttcattaca cagactgggt agatgatcag     1140

agacctgaaa actaccgtga ggccttgggt gatgttgttg gggattataa tttcatatgc     1200

cctgccttgg agttcaccaa gaagttctca gaatggggaa ataatgcctt tttctactat     1260

tttgaacacc gatcctccaa acttccgtgg ccagaatgga tgggagtgat gcatggctat     1320

gaaattgaat ttgtctttgg tttacctctg gaaagaagag ataattacac aaaagccgag     1380

gaaattttga gtagatccat agtgaaacgg tgggcaaatt ttgcaaaata tgggaatcca     1440

aatgagactc agaacaatag cacaagctgg cctgtcttca aaagcactga acaaaaatat     1500

ctaaccttga atacagagtc aacaagaata atgacgaaac tacgtgctca acaatgtcga     1560

ttctggacat cattttttcc aaaagtcgtg gagcctaagt cctgcgacaa aactcacaca     1620

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1680

aaacccaagg acaccctcta tatcacccgg gaacctgagg tcacatgcgt ggtggtggac     1740

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1800

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1860

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1920

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1980

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     2040

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2100

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2160

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2220

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2280

ggtaaa                                                                2286


