                         SEQUENCE LISTING

<110>  IFM Due, Inc.
 
<120>  METHODS OF TREATING CANCER

<130>  47110-0063WO1

<150>  63/129,242
<151>  2020-12-22

<160>  91    

<170>  PatentIn version 3.5

<210>  1
<211>  1140
<212>  DNA
<213>  Homo sapiens

<400>  1
atgccccact ccagcctgca tccatccatc ccgtgtccca ggggtcacgg ggcccagaag       60

gcagccttgg ttctgctgag tgcctgcctg gtgacccttt gggggctagg agagccacca      120

gagcacactc tccggtacct ggtgctccac ctagcctccc tgcagctggg actgctgtta      180

aacggggtct gcagcctggc tgaggagctg cgccacatcc actccaggta ccggggcagc      240

tactggagga ctgtgcgggc ctgcctgggc tgccccctcc gccgtggggc cctgttgctg      300

ctgtccatct atttctacta ctccctccca aatgcggtcg gcccgccctt cacttggatg      360

cttgccctcc tgggcctctc gcaggcactg aacatcctcc tgggcctcaa gggcctggcc      420

ccagctgaga tctctgcagt gtgtgaaaaa gggaatttca acgtggccca tgggctggca      480

tggtcatatt acatcggata tctgcggctg atcctgccag agctccaggc ccggattcga      540

acttacaatc agcattacaa caacctgcta cggggtgcag tgagccagcg gctgtatatt      600

ctcctcccat tggactgtgg ggtgcctgat aacctgagta tggctgaccc caacattcgc      660

ttcctggata aactgcccca gcagaccggt gaccatgctg gcatcaagga tcgggtttac      720

agcaacagca tctatgagct tctggagaac gggcagcggg cgggcacctg tgtcctggag      780

tacgccaccc ccttgcagac tttgtttgcc atgtcacaat acagtcaagc tggctttagc      840

cgggaggata ggcttgagca ggccaaactc ttctgccgga cacttgagga catcctggca      900

gatgcccctg agtctcagaa caactgccgc ctcattgcct accaggaacc tgcagatgac      960

agcagcttct cgctgtccca ggaggttctc cggcacctgc ggcaggagga aaaggaagag     1020

gttactgtgg gcagcttgaa gacctcagcg gtgcccagta cctccacgat gtcccaagag     1080

cctgagctcc tcatcagtgg aatggaaaag cccctccctc tccgcacgga tttctcttga     1140


<210>  2
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro His Ser Ser Leu His Pro Ser Ile Pro Cys Pro Arg Gly His 
1               5                   10                  15      


Gly Ala Gln Lys Ala Ala Leu Val Leu Leu Ser Ala Cys Leu Val Thr 
            20                  25                  30          


Leu Trp Gly Leu Gly Glu Pro Pro Glu His Thr Leu Arg Tyr Leu Val 
        35                  40                  45              


Leu His Leu Ala Ser Leu Gln Leu Gly Leu Leu Leu Asn Gly Val Cys 
    50                  55                  60                  


Ser Leu Ala Glu Glu Leu Arg His Ile His Ser Arg Tyr Arg Gly Ser 
65                  70                  75                  80  


Tyr Trp Arg Thr Val Arg Ala Cys Leu Gly Cys Pro Leu Arg Arg Gly 
                85                  90                  95      


Ala Leu Leu Leu Leu Ser Ile Tyr Phe Tyr Tyr Ser Leu Pro Asn Ala 
            100                 105                 110         


Val Gly Pro Pro Phe Thr Trp Met Leu Ala Leu Leu Gly Leu Ser Gln 
        115                 120                 125             


Ala Leu Asn Ile Leu Leu Gly Leu Lys Gly Leu Ala Pro Ala Glu Ile 
    130                 135                 140                 


Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Glu Leu Gln 
                165                 170                 175     


Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn Asn Leu Leu Arg Gly 
            180                 185                 190         


Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile Arg Phe Leu Asp Lys 
    210                 215                 220                 


Leu Pro Gln Gln Thr Gly Asp His Ala Gly Ile Lys Asp Arg Val Tyr 
225                 230                 235                 240 


Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly Gln Arg Ala Gly Thr 
                245                 250                 255     


Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala Met Ser 
            260                 265                 270         


Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp Arg Leu Glu Gln Ala 
        275                 280                 285             


Lys Leu Phe Cys Arg Thr Leu Glu Asp Ile Leu Ala Asp Ala Pro Glu 
    290                 295                 300                 


Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln Glu Pro Ala Asp Asp 
305                 310                 315                 320 


Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg His Leu Arg Gln Glu 
                325                 330                 335     


Glu Lys Glu Glu Val Thr Val Gly Ser Leu Lys Thr Ser Ala Val Pro 
            340                 345                 350         


Ser Thr Ser Thr Met Ser Gln Glu Pro Glu Leu Leu Ile Ser Gly Met 
        355                 360                 365             


Glu Lys Pro Leu Pro Leu Arg Thr Asp Phe Ser 
    370                 375                 


<210>  3
<211>  852
<212>  DNA
<213>  Homo sapiens

<400>  3
atgccccact ccagcctgca tccatccatc ccgtgtccca ggggtcacgg ggcccagaag       60

gcagccttgg ttctgctgag tgcctgcctg gtgacccttt gggggctagg agagccacca      120

gagcacactc tccggtacct ggtgctccac ctagcctccc tgcagctggg actgctgtta      180

aacggggtct gcagcctggc tgaggagctg cgccacatcc actccaggta ccggggcagc      240

tactggagga ctgtgcgggc ctgcctgggc tgccccctcc gccgtggggc cctgttgctg      300

ctgtccatct atttctacta ctccctccca aatgcggtcg gcccgccctt cacttggatg      360

cttgccctcc tgggcctctc gcaggcactg aacatcctcc tgggcctcaa gggcctggcc      420

ccagctgaga tctctgcagt gtgtgaaaaa gggaatttca acgtggccca tgggctggca      480

tggtcatatt acatcggata tctgcggctg atcctgccag agctccaggc ccggattcga      540

acttacaatc agcattacaa caacctgcta cggggtgcag tgagccagcg gctgtatatt      600

ctcctcccat tggactgtgg ggtgcctgat aacctgagta tggctgaccc caacattcgc      660

ttcctggata aactgcccca gcagaccggt gaccatgctg gcatcaagga tcgggtttac      720

agcaacagca tctatgagct tctggagaac gggcagcgga acctgcagat gacagcagct      780

tctcgctgtc ccaggaggtt ctccggcacc tgcggcagga ggaaaaggaa gaggttactg      840

tgggcagctt ga                                                          852


<210>  4
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro His Ser Ser Leu His Pro Ser Ile Pro Cys Pro Arg Gly His 
1               5                   10                  15      


Gly Ala Gln Lys Ala Ala Leu Val Leu Leu Ser Ala Cys Leu Val Thr 
            20                  25                  30          


Leu Trp Gly Leu Gly Glu Pro Pro Glu His Thr Leu Arg Tyr Leu Val 
        35                  40                  45              


Leu His Leu Ala Ser Leu Gln Leu Gly Leu Leu Leu Asn Gly Val Cys 
    50                  55                  60                  


Ser Leu Ala Glu Glu Leu Arg His Ile His Ser Arg Tyr Arg Gly Ser 
65                  70                  75                  80  


Tyr Trp Arg Thr Val Arg Ala Cys Leu Gly Cys Pro Leu Arg Arg Gly 
                85                  90                  95      


Ala Leu Leu Leu Leu Ser Ile Tyr Phe Tyr Tyr Ser Leu Pro Asn Ala 
            100                 105                 110         


Val Gly Pro Pro Phe Thr Trp Met Leu Ala Leu Leu Gly Leu Ser Gln 
        115                 120                 125             


Ala Leu Asn Ile Leu Leu Gly Leu Lys Gly Leu Ala Pro Ala Glu Ile 
    130                 135                 140                 


Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Glu Leu Gln 
                165                 170                 175     


Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn Asn Leu Leu Arg Gly 
            180                 185                 190         


Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile Arg Phe Leu Asp Lys 
    210                 215                 220                 


Leu Pro Gln Gln Thr Gly Asp Arg Ala Gly Ile Lys Asp Arg Val Tyr 
225                 230                 235                 240 


Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly Gln Arg Asn Leu Gln 
                245                 250                 255     


Met Thr Ala Ala Ser Arg Cys Pro Arg Arg Phe Ser Gly Thr Cys Gly 
            260                 265                 270         


Arg Arg Lys Arg Lys Arg Leu Leu Trp Ala Ala 
        275                 280             


<210>  5
<211>  783
<212>  DNA
<213>  Homo sapiens

<400>  5
atgcttgccc tcctgggcct ctcgcaggca ctgaacatcc tcctgggcct caagggcctg       60

gccccagctg agatctctgc agtgtgtgaa aaagggaatt tcaacgtggc ccatgggctg      120

gcatggtcat attacatcgg atatctgcgg ctgatcctgc cagagctcca ggcccggatt      180

cgaacttaca atcagcatta caacaacctg ctacggggtg cagtgagcca gcggctgtat      240

attctcctcc cattggactg tggggtgcct gataacctga gtatggctga ccccaacatt      300

cgcttcctgg ataaactgcc ccagcagacc ggtgaccatg ctggcatcaa ggatcgggtt      360

tacagcaaca gcatctatga gcttctggag aacgggcagc gggcgggcac ctgtgtcctg      420

gagtacgcca cccccttgca gactttgttt gccatgtcac aatacagtca agctggcttt      480

agccgggagg ataggcttga gcaggccaaa ctcttctgcc ggacacttga ggacatcctg      540

gcagatgccc ctgagtctca gaacaactgc cgcctcattg cctaccagga acctgcagat      600

gacagcagct tctcgctgtc ccaggaggtt ctccggcacc tgcggcagga ggaaaaggaa      660

gaggttactg tgggcagctt gaagacctca gcggtgccca gtacctccac gatgtcccaa      720

gagcctgagc tcctcatcag tggaatggaa aagcccctcc ctctccgcac ggatttctct      780

tga                                                                    783


<210>  6
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Ala Leu Leu Gly Leu Ser Gln Ala Leu Asn Ile Leu Leu Gly 
1               5                   10                  15      


Leu Lys Gly Leu Ala Pro Ala Glu Ile Ser Ala Val Cys Glu Lys Gly 
            20                  25                  30          


Asn Phe Asn Val Ala His Gly Leu Ala Trp Ser Tyr Tyr Ile Gly Tyr 
        35                  40                  45              


Leu Arg Leu Ile Leu Pro Glu Leu Gln Ala Arg Ile Arg Thr Tyr Asn 
    50                  55                  60                  


Gln His Tyr Asn Asn Leu Leu Arg Gly Ala Val Ser Gln Arg Leu Tyr 
65                  70                  75                  80  


Ile Leu Leu Pro Leu Asp Cys Gly Val Pro Asp Asn Leu Ser Met Ala 
                85                  90                  95      


Asp Pro Asn Ile Arg Phe Leu Asp Lys Leu Pro Gln Gln Thr Gly Asp 
            100                 105                 110         


His Ala Gly Ile Lys Asp Arg Val Tyr Ser Asn Ser Ile Tyr Glu Leu 
        115                 120                 125             


Leu Glu Asn Gly Gln Arg Ala Gly Thr Cys Val Leu Glu Tyr Ala Thr 
    130                 135                 140                 


Pro Leu Gln Thr Leu Phe Ala Met Ser Gln Tyr Ser Gln Ala Gly Phe 
145                 150                 155                 160 


Ser Arg Glu Asp Arg Leu Glu Gln Ala Lys Leu Phe Cys Arg Thr Leu 
                165                 170                 175     


Glu Asp Ile Leu Ala Asp Ala Pro Glu Ser Gln Asn Asn Cys Arg Leu 
            180                 185                 190         


Ile Ala Tyr Gln Glu Pro Ala Asp Asp Ser Ser Phe Ser Leu Ser Gln 
        195                 200                 205             


Glu Val Leu Arg His Leu Arg Gln Glu Glu Lys Glu Glu Val Thr Val 
    210                 215                 220                 


Gly Ser Leu Lys Thr Ser Ala Val Pro Ser Thr Ser Thr Met Ser Gln 
225                 230                 235                 240 


Glu Pro Glu Leu Leu Ile Ser Gly Met Glu Lys Pro Leu Pro Leu Arg 
                245                 250                 255     


Thr Asp Phe Ser 
            260 


<210>  7
<211>  735
<212>  DNA
<213>  Homo sapiens

<400>  7
ctcaagggcc tggccccagc tgagatctct gcagtgtgtg aaaaagggaa tttcaacgtg       60

gcccatgggc tggcatggtc atattacatc ggatatctgc ggctgatcct gccagagctc      120

caggcccgga ttcgaactta caatcagcat tacaacaacc tgctacgggg tgcagtgagc      180

cagcggctgt atattctcct cccattggac tgtggggtgc ctgataacct gagtatggct      240

gaccccaaca ttcgcttcct ggataaactg ccccagcaga ccggtgacca tgctggcatc      300

aaggatcggg tttacagcaa cagcatctat gagcttctgg agaacgggca gcgggcgggc      360

acctgtgtcc tggagtacgc cacccccttg cagactttgt ttgccatgtc acaatacagt      420

caagctggct ttagccggga ggataggctt gagcaggcca aactcttctg ccggacactt      480

gaggacatcc tggcagatgc ccctgagtct cagaacaact gccgcctcat tgcctaccag      540

gaacctgcag atgacagcag cttctcgctg tcccaggagg ttctccggca cctgcggcag      600

gaggaaaagg aagaggttac tgtgggcagc ttgaagacct cagcggtgcc cagtacctcc      660

acgatgtccc aagagcctga gctcctcatc agtggaatgg aaaagcccct ccctctccgc      720

acggatttct cttga                                                       735


<210>  8
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  8

Leu Lys Gly Leu Ala Pro Ala Glu Ile Ser Ala Val Cys Glu Lys Gly 
1               5                   10                  15      


Asn Phe Asn Val Ala His Gly Leu Ala Trp Ser Tyr Tyr Ile Gly Tyr 
            20                  25                  30          


Leu Arg Leu Ile Leu Pro Glu Leu Gln Ala Arg Ile Arg Thr Tyr Asn 
        35                  40                  45              


Gln His Tyr Asn Asn Leu Leu Arg Gly Ala Val Ser Gln Arg Leu Tyr 
    50                  55                  60                  


Ile Leu Leu Pro Leu Asp Cys Gly Val Pro Asp Asn Leu Ser Met Ala 
65                  70                  75                  80  


Asp Pro Asn Ile Arg Phe Leu Asp Lys Leu Pro Gln Gln Thr Gly Asp 
                85                  90                  95      


His Ala Gly Ile Lys Asp Arg Val Tyr Ser Asn Ser Ile Tyr Glu Leu 
            100                 105                 110         


Leu Glu Asn Gly Gln Arg Ala Gly Thr Cys Val Leu Glu Tyr Ala Thr 
        115                 120                 125             


Pro Leu Gln Thr Leu Phe Ala Met Ser Gln Tyr Ser Gln Ala Gly Phe 
    130                 135                 140                 


Ser Arg Glu Asp Arg Leu Glu Gln Ala Lys Leu Phe Cys Arg Thr Leu 
145                 150                 155                 160 


Glu Asp Ile Leu Ala Asp Ala Pro Glu Ser Gln Asn Asn Cys Arg Leu 
                165                 170                 175     


Ile Ala Tyr Gln Glu Pro Ala Asp Asp Ser Ser Phe Ser Leu Ser Gln 
            180                 185                 190         


Glu Val Leu Arg His Leu Arg Gln Glu Glu Lys Glu Glu Val Thr Val 
        195                 200                 205             


Gly Ser Leu Lys Thr Ser Ala Val Pro Ser Thr Ser Thr Met Ser Gln 
    210                 215                 220                 


Glu Pro Glu Leu Leu Ile Ser Gly Met Glu Lys Pro Leu Pro Leu Arg 
225                 230                 235                 240 


Thr Asp Phe Ser 
                


<210>  9
<211>  945
<212>  DNA
<213>  Homo sapiens

<400>  9
atgggctcgc aggccctgcc cccggggccc atgcagaccc tcatcttttt cgacatggag       60

gccactggct tgcccttctc ccagcccaag gtcacggagc tgtgcctgct ggctgtccac      120

agatgtgccc tggagagccc ccccacctct caggggccac ctcccacagt tcctccacca      180

ccgcgtgtgg tagacaagct ctccctgtgt gtggctccgg ggaaggcctg cagccctgca      240

gccagcgaga tcacaggtct gagcacagct gtgctggcag cgcatgggcg tcaatgtttt      300

gatgacaacc tggccaacct gctcctagcc ttcctgcggc gccagccaca gccctggtgc      360

ctggtggcac acaatggtga ccgctacgac ttccccctgc tccaagcaga gctggctatg      420

ctgggcctca ccagtgctct ggatggtgcc ttctgtgtgg atagcatcac tgcgctgaag      480

gccctggagc gagcaagcag cccctcagaa cacggcccaa ggaagagcta tagcctaggc      540

agcatctaca ctcgcctgta tgggcagtcc cctccagact cgcacacggc tgagggtgat      600

gtcctggccc tgctcagcat ctgtcagtgg agaccacagg ccctgctgcg gtgggtggat      660

gctcacgcca ggcctttcgg caccatcagg cccatgtatg gggtcacagc ctctgctagg      720

accaagccaa gaccatctgc tgtcacaacc actgcacacc tggccacaac caggaacact      780

agtcccagcc ttggagagag caggggtacc aaggatcttc ctccagtgaa ggaccctgga      840

gccctatcca gggaggggct gctggcccca ctgggtctgc tggccatcct gaccttggca      900

gtagccacac tgtatggact atccctggcc acacctgggg agtag                      945


<210>  10
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Ser Gln Ala Leu Pro Pro Gly Pro Met Gln Thr Leu Ile Phe 
1               5                   10                  15      


Phe Asp Met Glu Ala Thr Gly Leu Pro Phe Ser Gln Pro Lys Val Thr 
            20                  25                  30          


Glu Leu Cys Leu Leu Ala Val His Arg Cys Ala Leu Glu Ser Pro Pro 
        35                  40                  45              


Thr Ser Gln Gly Pro Pro Pro Thr Val Pro Pro Pro Pro Arg Val Val 
    50                  55                  60                  


Asp Lys Leu Ser Leu Cys Val Ala Pro Gly Lys Ala Cys Ser Pro Ala 
65                  70                  75                  80  


Ala Ser Glu Ile Thr Gly Leu Ser Thr Ala Val Leu Ala Ala His Gly 
                85                  90                  95      


Arg Gln Cys Phe Asp Asp Asn Leu Ala Asn Leu Leu Leu Ala Phe Leu 
            100                 105                 110         


Arg Arg Gln Pro Gln Pro Trp Cys Leu Val Ala His Asn Gly Asp Arg 
        115                 120                 125             


Tyr Asp Phe Pro Leu Leu Gln Ala Glu Leu Ala Met Leu Gly Leu Thr 
    130                 135                 140                 


Ser Ala Leu Asp Gly Ala Phe Cys Val Asp Ser Ile Thr Ala Leu Lys 
145                 150                 155                 160 


Ala Leu Glu Arg Ala Ser Ser Pro Ser Glu His Gly Pro Arg Lys Ser 
                165                 170                 175     


Tyr Ser Leu Gly Ser Ile Tyr Thr Arg Leu Tyr Gly Gln Ser Pro Pro 
            180                 185                 190         


Asp Ser His Thr Ala Glu Gly Asp Val Leu Ala Leu Leu Ser Ile Cys 
        195                 200                 205             


Gln Trp Arg Pro Gln Ala Leu Leu Arg Trp Val Asp Ala His Ala Arg 
    210                 215                 220                 


Pro Phe Gly Thr Ile Arg Pro Met Tyr Gly Val Thr Ala Ser Ala Arg 
225                 230                 235                 240 


Thr Lys Pro Arg Pro Ser Ala Val Thr Thr Thr Ala His Leu Ala Thr 
                245                 250                 255     


Thr Arg Asn Thr Ser Pro Ser Leu Gly Glu Ser Arg Gly Thr Lys Asp 
            260                 265                 270         


Leu Pro Pro Val Lys Asp Pro Gly Ala Leu Ser Arg Glu Gly Leu Leu 
        275                 280                 285             


Ala Pro Leu Gly Leu Leu Ala Ile Leu Thr Leu Ala Val Ala Thr Leu 
    290                 295                 300                 


Tyr Gly Leu Ser Leu Ala Thr Pro Gly Glu 
305                 310                 


<210>  11
<211>  915
<212>  DNA
<213>  Homo sapiens

<400>  11
atgcagaccc tcatcttttt cgacatggag gccactggct tgcccttctc ccagcccaag       60

gtcacggagc tgtgcctgct ggctgtccac agatgtgccc tggagagccc ccccacctct      120

caggggccac ctcccacagt tcctccacca ccgcgtgtgg tagacaagct ctccctgtgt      180

gtggctccgg ggaaggcctg cagccctgca gccagcgaga tcacaggtct gagcacagct      240

gtgctggcag cgcatgggcg tcaatgtttt gatgacaacc tggccaacct gctcctagcc      300

ttcctgcggc gccagccaca gccctggtgc ctggtggcac acaatggtga ccgctacgac      360

ttccccctgc tccaagcaga gctggctatg ctgggcctca ccagtgctct ggatggtgcc      420

ttctgtgtgg atagcatcac tgcgctgaag gccctggagc gagcaagcag cccctcagaa      480

cacggcccaa ggaagagcta tagcctaggc agcatctaca ctcgcctgta tgggcagtcc      540

cctccagact cgcacacggc tgagggtgat gtcctggccc tgctcagcat ctgtcagtgg      600

agaccacagg ccctgctgcg gtgggtggat gctcacgcca ggcctttcgg caccatcagg      660

cccatgtatg gggtcacagc ctctgctagg accaagccaa gaccatctgc tgtcacaacc      720

actgcacacc tggccacaac caggaacact agtcccagcc ttggagagag caggggtacc      780

aaggatcttc ctccagtgaa ggaccctgga gccctatcca gggaggggct gctggcccca      840

ctgggtctgc tggccatcct gaccttggca gtagccacac tgtatggact atccctggcc      900

acacctgggg agtag                                                       915


<210>  12
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gln Thr Leu Ile Phe Phe Asp Met Glu Ala Thr Gly Leu Pro Phe 
1               5                   10                  15      


Ser Gln Pro Lys Val Thr Glu Leu Cys Leu Leu Ala Val His Arg Cys 
            20                  25                  30          


Ala Leu Glu Ser Pro Pro Thr Ser Gln Gly Pro Pro Pro Thr Val Pro 
        35                  40                  45              


Pro Pro Pro Arg Val Val Asp Lys Leu Ser Leu Cys Val Ala Pro Gly 
    50                  55                  60                  


Lys Ala Cys Ser Pro Ala Ala Ser Glu Ile Thr Gly Leu Ser Thr Ala 
65                  70                  75                  80  


Val Leu Ala Ala His Gly Arg Gln Cys Phe Asp Asp Asn Leu Ala Asn 
                85                  90                  95      


Leu Leu Leu Ala Phe Leu Arg Arg Gln Pro Gln Pro Trp Cys Leu Val 
            100                 105                 110         


Ala His Asn Gly Asp Arg Tyr Asp Phe Pro Leu Leu Gln Ala Glu Leu 
        115                 120                 125             


Ala Met Leu Gly Leu Thr Ser Ala Leu Asp Gly Ala Phe Cys Val Asp 
    130                 135                 140                 


Ser Ile Thr Ala Leu Lys Ala Leu Glu Arg Ala Ser Ser Pro Ser Glu 
145                 150                 155                 160 


His Gly Pro Arg Lys Ser Tyr Ser Leu Gly Ser Ile Tyr Thr Arg Leu 
                165                 170                 175     


Tyr Gly Gln Ser Pro Pro Asp Ser His Thr Ala Glu Gly Asp Val Leu 
            180                 185                 190         


Ala Leu Leu Ser Ile Cys Gln Trp Arg Pro Gln Ala Leu Leu Arg Trp 
        195                 200                 205             


Val Asp Ala His Ala Arg Pro Phe Gly Thr Ile Arg Pro Met Tyr Gly 
    210                 215                 220                 


Val Thr Ala Ser Ala Arg Thr Lys Pro Arg Pro Ser Ala Val Thr Thr 
225                 230                 235                 240 


Thr Ala His Leu Ala Thr Thr Arg Asn Thr Ser Pro Ser Leu Gly Glu 
                245                 250                 255     


Ser Arg Gly Thr Lys Asp Leu Pro Pro Val Lys Asp Pro Gly Ala Leu 
            260                 265                 270         


Ser Arg Glu Gly Leu Leu Ala Pro Leu Gly Leu Leu Ala Ile Leu Thr 
        275                 280                 285             


Leu Ala Val Ala Thr Leu Tyr Gly Leu Ser Leu Ala Thr Pro Gly Glu 
    290                 295                 300                 


<210>  13
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Pro Gly Ala Arg Arg Gln Gly Arg Ile Val Gln Gly Arg Pro 
1               5                   10                  15      


Glu Met Cys Phe Cys Pro Pro Pro Thr Pro Leu Pro Pro Leu Arg Ile 
            20                  25                  30          


Leu Thr Leu Gly Thr His Thr Pro Thr Pro Cys Ser Ser Pro Gly Ser 
        35                  40                  45              


Ala Ala Gly Thr Tyr Pro Thr Met Gly Ser Gln Ala Leu Pro Pro Gly 
    50                  55                  60                  


Pro Met Gln Thr Leu Ile Phe Phe Asp Met Glu Ala Thr Gly Leu Pro 
65                  70                  75                  80  


Phe Ser Gln Pro Lys Val Thr Glu Leu Cys Leu Leu Ala Val His Arg 
                85                  90                  95      


Cys Ala Leu Glu Ser Pro Pro Thr Ser Gln Gly Pro Pro Pro Thr Val 
            100                 105                 110         


Pro Pro Pro Pro Arg Val Val Asp Lys Leu Ser Leu Cys Val Ala Pro 
        115                 120                 125             


Gly Lys Ala Cys Ser Pro Ala Ala Ser Glu Ile Thr Gly Leu Ser Thr 
    130                 135                 140                 


Ala Val Leu Ala Ala His Gly Arg Gln Cys Phe Asp Asp Asn Leu Ala 
145                 150                 155                 160 


Asn Leu Leu Leu Ala Phe Leu Arg Arg Gln Pro Gln Pro Trp Cys Leu 
                165                 170                 175     


Val Ala His Asn Gly Asp Arg Tyr Asp Phe Pro Leu Leu Gln Ala Glu 
            180                 185                 190         


Leu Ala Met Leu Gly Leu Thr Ser Ala Leu Asp Gly Ala Phe Cys Val 
        195                 200                 205             


Asp Ser Ile Thr Ala Leu Lys Ala Leu Glu Arg Ala Ser Ser Pro Ser 
    210                 215                 220                 


Glu His Gly Pro Arg Lys Ser Tyr Ser Leu Gly Ser Ile Tyr Thr Arg 
225                 230                 235                 240 


Leu Tyr Gly Gln Ser Pro Pro Asp Ser His Thr Ala Glu Gly Asp Val 
                245                 250                 255     


Leu Ala Leu Leu Ser Ile Cys Gln Trp Arg Pro Gln Ala Leu Leu Arg 
            260                 265                 270         


Trp Val Asp Ala His Ala Arg Pro Phe Gly Thr Ile Arg Pro Met Tyr 
        275                 280                 285             


Gly Val Thr Ala Ser Ala Arg Thr Lys Pro Arg Pro Ser Ala Val Thr 
    290                 295                 300                 


Thr Thr Ala His Leu Ala Thr Thr Arg Asn Thr Ser Pro Ser Leu Gly 
305                 310                 315                 320 


Glu Ser Arg Gly Thr Lys Asp Leu Pro Pro Val Lys Asp Pro Gly Ala 
                325                 330                 335     


Leu Ser Arg Glu Gly Leu Leu Ala Pro Leu Gly Leu Leu Ala Ile Leu 
            340                 345                 350         


Thr Leu Ala Val Ala Thr Leu Tyr Gly Leu Ser Leu Ala Thr Pro Gly 
        355                 360                 365             


Glu 
    


<210>  14
<211>  5592
<212>  DNA
<213>  Homo sapiens

<400>  14
atggatttat ctgctcttcg cgttgaagaa gtacaaaatg tcattaatgc tatgcagaaa       60

atcttagagt gtcccatctg tctggagttg atcaaggaac ctgtctccac aaagtgtgac      120

cacatatttt gcaaattttg catgctgaaa cttctcaacc agaagaaagg gccttcacag      180

tgtcctttat gtaagaatga tataaccaaa aggagcctac aagaaagtac gagatttagt      240

caacttgttg aagagctatt gaaaatcatt tgtgcttttc agcttgacac aggtttggag      300

tatgcaaaca gctataattt tgcaaaaaag gaaaataact ctcctgaaca tctaaaagat      360

gaagtttcta tcatccaaag tatgggctac agaaaccgtg ccaaaagact tctacagagt      420

gaacccgaaa atccttcctt gcaggaaacc agtctcagtg tccaactctc taaccttgga      480

actgtgagaa ctctgaggac aaagcagcgg atacaacctc aaaagacgtc tgtctacatt      540

gaattgggat ctgattcttc tgaagatacc gttaataagg caacttattg cagtgtggga      600

gatcaagaat tgttacaaat cacccctcaa ggaaccaggg atgaaatcag tttggattct      660

gcaaaaaagg ctgcttgtga attttctgag acggatgtaa caaatactga acatcatcaa      720

cccagtaata atgatttgaa caccactgag aagcgtgcag ctgagaggca tccagaaaag      780

tatcagggta gttctgtttc aaacttgcat gtggagccat gtggcacaaa tactcatgcc      840

agctcattac agcatgagaa cagcagttta ttactcacta aagacagaat gaatgtagaa      900

aaggctgaat tctgtaataa aagcaaacag cctggcttag caaggagcca acataacaga      960

tgggctggaa gtaaggaaac atgtaatgat aggcggactc ccagcacaga aaaaaaggta     1020

gatctgaatg ctgatcccct gtgtgagaga aaagaatgga ataagcagaa actgccatgc     1080

tcagagaatc ctagagatac tgaagatgtt ccttggataa cactaaatag cagcattcag     1140

aaagttaatg agtggttttc cagaagtgat gaactgttag gttctgatga ctcacatgat     1200

ggggagtctg aatcaaatgc caaagtagct gatgtattgg acgttctaaa tgaggtagat     1260

gaatattctg gttcttcaga gaaaatagac ttactggcca gtgatcctca tgaggcttta     1320

atatgtaaaa gtgaaagagt tcactccaaa tcagtagaga gtaatattga agacaaaata     1380

tttgggaaaa cctatcggaa gaaggcaagc ctccccaact taagccatgt aactgaaaat     1440

ctaattatag gagcatttgt tactgagcca cagataatac aagagcgtcc cctcacaaat     1500

aaattaaagc gtaaaaggag acctacatca ggccttcatc ctgaggattt tatcaagaaa     1560

gcagatttgg cagttcaaaa gactcctgaa atgataaatc agggaactaa ccaaacggag     1620

cagaatggtc aagtgatgaa tattactaat agtggtcatg agaataaaac aaaaggtgat     1680

tctattcaga atgagaaaaa tcctaaccca atagaatcac tcgaaaaaga atctgctttc     1740

aaaacgaaag ctgaacctat aagcagcagt ataagcaata tggaactcga attaaatatc     1800

cacaattcaa aagcacctaa aaagaatagg ctgaggagga agtcttctac caggcatatt     1860

catgcgcttg aactagtagt cagtagaaat ctaagcccac ctaattgtac tgaattgcaa     1920

attgatagtt gttctagcag tgaagagata aagaaaaaaa agtacaacca aatgccagtc     1980

aggcacagca gaaacctaca actcatggaa ggtaaagaac ctgcaactgg agccaagaag     2040

agtaacaagc caaatgaaca gacaagtaaa agacatgaca gcgatacttt cccagagctg     2100

aagttaacaa atgcacctgg ttcttttact aagtgttcaa ataccagtga acttaaagaa     2160

tttgtcaatc ctagccttcc aagagaagaa aaagaagaga aactagaaac agttaaagtg     2220

tctaataatg ctgaagaccc caaagatctc atgttaagtg gagaaagggt tttgcaaact     2280

gaaagatctg tagagagtag cagtatttca ttggtacctg gtactgatta tggcactcag     2340

gaaagtatct cgttactgga agttagcact ctagggaagg caaaaacaga accaaataaa     2400

tgtgtgagtc agtgtgcagc atttgaaaac cccaagggac taattcatgg ttgttccaaa     2460

gataatagaa atgacacaga aggctttaag tatccattgg gacatgaagt taaccacagt     2520

cgggaaacaa gcatagaaat ggaagaaagt gaacttgatg ctcagtattt gcagaataca     2580

ttcaaggttt caaagcgcca gtcatttgct ccgttttcaa atccaggaaa tgcagaagag     2640

gaatgtgcaa cattctctgc ccactctggg tccttaaaga aacaaagtcc aaaagtcact     2700

tttgaatgtg aacaaaagga agaaaatcaa ggaaagaatg agtctaatat caagcctgta     2760

cagacagtta atatcactgc aggctttcct gtggttggtc agaaagataa gccagttgat     2820

aatgccaaat gtagtatcaa aggaggctct aggttttgtc tatcatctca gttcagaggc     2880

aacgaaactg gactcattac tccaaataaa catggacttt tacaaaaccc atatcgtata     2940

ccaccacttt ttcccatcaa gtcatttgtt aaaactaaat gtaagaaaaa tctgctagag     3000

gaaaactttg aggaacattc aatgtcacct gaaagagaaa tgggaaatga gaacattcca     3060

agtacagtga gcacaattag ccgtaataac attagagaaa atgtttttaa agaagccagc     3120

tcaagcaata ttaatgaagt aggttccagt actaatgaag tgggctccag tattaatgaa     3180

ataggttcca gtgatgaaaa cattcaagca gaactaggta gaaacagagg gccaaaattg     3240

aatgctatgc ttagattagg ggttttgcaa cctgaggtct ataaacaaag tcttcctgga     3300

agtaattgta agcatcctga aataaaaaag caagaatatg aagaagtagt tcagactgtt     3360

aatacagatt tctctccata tctgatttca gataacttag aacagcctat gggaagtagt     3420

catgcatctc aggtttgttc tgagacacct gatgacctgt tagatgatgg tgaaataaag     3480

gaagatacta gttttgctga aaatgacatt aaggaaagtt ctgctgtttt tagcaaaagc     3540

gtccagaaag gagagcttag caggagtcct agccctttca cccatacaca tttggctcag     3600

ggttaccgaa gaggggccaa gaaattagag tcctcagaag agaacttatc tagtgaggat     3660

gaagagcttc cctgcttcca acacttgtta tttggtaaag taaacaatat accttctcag     3720

tctactaggc atagcaccgt tgctaccgag tgtctgtcta agaacacaga ggagaattta     3780

ttatcattga agaatagctt aaatgactgc agtaaccagg taatattggc aaaggcatct     3840

caggaacatc accttagtga ggaaacaaaa tgttctgcta gcttgttttc ttcacagtgc     3900

agtgaattgg aagacttgac tgcaaataca aacacccagg atcctttctt gattggttct     3960

tccaaacaaa tgaggcatca gtctgaaagc cagggagttg gtctgagtga caaggaattg     4020

gtttcagatg atgaagaaag aggaacgggc ttggaagaaa ataatcaaga agagcaaagc     4080

atggattcaa acttaggtga agcagcatct gggtgtgaga gtgaaacaag cgtctctgaa     4140

gactgctcag ggctatcctc tcagagtgac attttaacca ctcagcagag ggataccatg     4200

caacataacc tgataaagct ccagcaggaa atggctgaac tagaagctgt gttagaacag     4260

catgggagcc agccttctaa cagctaccct tccatcataa gtgactcttc tgcccttgag     4320

gacctgcgaa atccagaaca aagcacatca gaaaaagcag tattaacttc acagaaaagt     4380

agtgaatacc ctataagcca gaatccagaa ggcctttctg ctgacaagtt tgaggtgtct     4440

gcagatagtt ctaccagtaa aaataaagaa ccaggagtgg aaaggtcatc cccttctaaa     4500

tgcccatcat tagatgatag gtggtacatg cacagttgct ctgggagtct tcagaataga     4560

aactacccat ctcaagagga gctcattaag gttgttgatg tggaggagca acagctggaa     4620

gagtctgggc cacacgattt gacggaaaca tcttacttgc caaggcaaga tctagaggga     4680

accccttacc tggaatctgg aatcagcctc ttctctgatg accctgaatc tgatccttct     4740

gaagacagag ccccagagtc agctcgtgtt ggcaacatac catcttcaac ctctgcattg     4800

aaagttcccc aattgaaagt tgcagaatct gcccagagtc cagctgctgc tcatactact     4860

gatactgctg ggtataatgc aatggaagaa agtgtgagca gggagaagcc agaattgaca     4920

gcttcaacag aaagggtcaa caaaagaatg tccatggtgg tgtctggcct gaccccagaa     4980

gaatttatgc tcgtgtacaa gtttgccaga aaacaccaca tcactttaac taatctaatt     5040

actgaagaga ctactcatgt tgttatgaaa acagatgctg agtttgtgtg tgaacggaca     5100

ctgaaatatt ttctaggaat tgcgggagga aaatgggtag ttagctattt ctgggtgacc     5160

cagtctatta aagaaagaaa aatgctgaat gagcatgatt ttgaagtcag aggagatgtg     5220

gtcaatggaa gaaaccacca aggtccaaag cgagcaagag aatcccagga cagaaagatc     5280

ttcagggggc tagaaatctg ttgctatggg cccttcacca acatgcccac agatcaactg     5340

gaatggatgg tacagctgtg tggtgcttct gtggtgaagg agctttcatc attcaccctt     5400

ggcacaggtg tccacccaat tgtggttgtg cagccagatg cctggacaga ggacaatggc     5460

ttccatgcaa ttgggcagat gtgtgaggca cctgtggtga cccgagagtg ggtgttggac     5520

agtgtagcac tctaccagtg ccaggagctg gacacctacc tgatacccca gatcccccac     5580

agccactact ga                                                         5592


<210>  15
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  16
<211>  5451
<212>  DNA
<213>  Homo sapiens

<400>  16
atgctgaaac ttctcaacca gaagaaaggg ccttcacagt gtcctttatg taagaatgat       60

ataaccaaaa ggagcctaca agaaagtacg agatttagtc aacttgttga agagctattg      120

aaaatcattt gtgcttttca gcttgacaca ggtttggagt atgcaaacag ctataatttt      180

gcaaaaaagg aaaataactc tcctgaacat ctaaaagatg aagtttctat catccaaagt      240

atgggctaca gaaaccgtgc caaaagactt ctacagagtg aacccgaaaa tccttccttg      300

caggaaacca gtctcagtgt ccaactctct aaccttggaa ctgtgagaac tctgaggaca      360

aagcagcgga tacaacctca aaagacgtct gtctacattg aattgggatc tgattcttct      420

gaagataccg ttaataaggc aacttattgc agtgtgggag atcaagaatt gttacaaatc      480

acccctcaag gaaccaggga tgaaatcagt ttggattctg caaaaaaggc tgcttgtgaa      540

ttttctgaga cggatgtaac aaatactgaa catcatcaac ccagtaataa tgatttgaac      600

accactgaga agcgtgcagc tgagaggcat ccagaaaagt atcagggtag ttctgtttca      660

aacttgcatg tggagccatg tggcacaaat actcatgcca gctcattaca gcatgagaac      720

agcagtttat tactcactaa agacagaatg aatgtagaaa aggctgaatt ctgtaataaa      780

agcaaacagc ctggcttagc aaggagccaa cataacagat gggctggaag taaggaaaca      840

tgtaatgata ggcggactcc cagcacagaa aaaaaggtag atctgaatgc tgatcccctg      900

tgtgagagaa aagaatggaa taagcagaaa ctgccatgct cagagaatcc tagagatact      960

gaagatgttc cttggataac actaaatagc agcattcaga aagttaatga gtggttttcc     1020

agaagtgatg aactgttagg ttctgatgac tcacatgatg gggagtctga atcaaatgcc     1080

aaagtagctg atgtattgga cgttctaaat gaggtagatg aatattctgg ttcttcagag     1140

aaaatagact tactggccag tgatcctcat gaggctttaa tatgtaaaag tgaaagagtt     1200

cactccaaat cagtagagag taatattgaa gacaaaatat ttgggaaaac ctatcggaag     1260

aaggcaagcc tccccaactt aagccatgta actgaaaatc taattatagg agcatttgtt     1320

actgagccac agataataca agagcgtccc ctcacaaata aattaaagcg taaaaggaga     1380

cctacatcag gccttcatcc tgaggatttt atcaagaaag cagatttggc agttcaaaag     1440

actcctgaaa tgataaatca gggaactaac caaacggagc agaatggtca agtgatgaat     1500

attactaata gtggtcatga gaataaaaca aaaggtgatt ctattcagaa tgagaaaaat     1560

cctaacccaa tagaatcact cgaaaaagaa tctgctttca aaacgaaagc tgaacctata     1620

agcagcagta taagcaatat ggaactcgaa ttaaatatcc acaattcaaa agcacctaaa     1680

aagaataggc tgaggaggaa gtcttctacc aggcatattc atgcgcttga actagtagtc     1740

agtagaaatc taagcccacc taattgtact gaattgcaaa ttgatagttg ttctagcagt     1800

gaagagataa agaaaaaaaa gtacaaccaa atgccagtca ggcacagcag aaacctacaa     1860

ctcatggaag gtaaagaacc tgcaactgga gccaagaaga gtaacaagcc aaatgaacag     1920

acaagtaaaa gacatgacag cgatactttc ccagagctga agttaacaaa tgcacctggt     1980

tcttttacta agtgttcaaa taccagtgaa cttaaagaat ttgtcaatcc tagccttcca     2040

agagaagaaa aagaagagaa actagaaaca gttaaagtgt ctaataatgc tgaagacccc     2100

aaagatctca tgttaagtgg agaaagggtt ttgcaaactg aaagatctgt agagagtagc     2160

agtatttcat tggtacctgg tactgattat ggcactcagg aaagtatctc gttactggaa     2220

gttagcactc tagggaaggc aaaaacagaa ccaaataaat gtgtgagtca gtgtgcagca     2280

tttgaaaacc ccaagggact aattcatggt tgttccaaag ataatagaaa tgacacagaa     2340

ggctttaagt atccattggg acatgaagtt aaccacagtc gggaaacaag catagaaatg     2400

gaagaaagtg aacttgatgc tcagtatttg cagaatacat tcaaggtttc aaagcgccag     2460

tcatttgctc cgttttcaaa tccaggaaat gcagaagagg aatgtgcaac attctctgcc     2520

cactctgggt ccttaaagaa acaaagtcca aaagtcactt ttgaatgtga acaaaaggaa     2580

gaaaatcaag gaaagaatga gtctaatatc aagcctgtac agacagttaa tatcactgca     2640

ggctttcctg tggttggtca gaaagataag ccagttgata atgccaaatg tagtatcaaa     2700

ggaggctcta ggttttgtct atcatctcag ttcagaggca acgaaactgg actcattact     2760

ccaaataaac atggactttt acaaaaccca tatcgtatac caccactttt tcccatcaag     2820

tcatttgtta aaactaaatg taagaaaaat ctgctagagg aaaactttga ggaacattca     2880

atgtcacctg aaagagaaat gggaaatgag aacattccaa gtacagtgag cacaattagc     2940

cgtaataaca ttagagaaaa tgtttttaaa gaagccagct caagcaatat taatgaagta     3000

ggttccagta ctaatgaagt gggctccagt attaatgaaa taggttccag tgatgaaaac     3060

attcaagcag aactaggtag aaacagaggg ccaaaattga atgctatgct tagattaggg     3120

gttttgcaac ctgaggtcta taaacaaagt cttcctggaa gtaattgtaa gcatcctgaa     3180

ataaaaaagc aagaatatga agaagtagtt cagactgtta atacagattt ctctccatat     3240

ctgatttcag ataacttaga acagcctatg ggaagtagtc atgcatctca ggtttgttct     3300

gagacacctg atgacctgtt agatgatggt gaaataaagg aagatactag ttttgctgaa     3360

aatgacatta aggaaagttc tgctgttttt agcaaaagcg tccagaaagg agagcttagc     3420

aggagtccta gccctttcac ccatacacat ttggctcagg gttaccgaag aggggccaag     3480

aaattagagt cctcagaaga gaacttatct agtgaggatg aagagcttcc ctgcttccaa     3540

cacttgttat ttggtaaagt aaacaatata ccttctcagt ctactaggca tagcaccgtt     3600

gctaccgagt gtctgtctaa gaacacagag gagaatttat tatcattgaa gaatagctta     3660

aatgactgca gtaaccaggt aatattggca aaggcatctc aggaacatca ccttagtgag     3720

gaaacaaaat gttctgctag cttgttttct tcacagtgca gtgaattgga agacttgact     3780

gcaaatacaa acacccagga tcctttcttg attggttctt ccaaacaaat gaggcatcag     3840

tctgaaagcc agggagttgg tctgagtgac aaggaattgg tttcagatga tgaagaaaga     3900

ggaacgggct tggaagaaaa taatcaagaa gagcaaagca tggattcaaa cttaggtgaa     3960

gcagcatctg ggtgtgagag tgaaacaagc gtctctgaag actgctcagg gctatcctct     4020

cagagtgaca ttttaaccac tcagcagagg gataccatgc aacataacct gataaagctc     4080

cagcaggaaa tggctgaact agaagctgtg ttagaacagc atgggagcca gccttctaac     4140

agctaccctt ccatcataag tgactcttct gcccttgagg acctgcgaaa tccagaacaa     4200

agcacatcag aaaaagcagt attaacttca cagaaaagta gtgaataccc tataagccag     4260

aatccagaag gcctttctgc tgacaagttt gaggtgtctg cagatagttc taccagtaaa     4320

aataaagaac caggagtgga aaggtcatcc ccttctaaat gcccatcatt agatgatagg     4380

tggtacatgc acagttgctc tgggagtctt cagaatagaa actacccatc tcaagaggag     4440

ctcattaagg ttgttgatgt ggaggagcaa cagctggaag agtctgggcc acacgatttg     4500

acggaaacat cttacttgcc aaggcaagat ctagagggaa ccccttacct ggaatctgga     4560

atcagcctct tctctgatga ccctgaatct gatccttctg aagacagagc cccagagtca     4620

gctcgtgttg gcaacatacc atcttcaacc tctgcattga aagttcccca attgaaagtt     4680

gcagaatctg cccagagtcc agctgctgct catactactg atactgctgg gtataatgca     4740

atggaagaaa gtgtgagcag ggagaagcca gaattgacag cttcaacaga aagggtcaac     4800

aaaagaatgt ccatggtggt gtctggcctg accccagaag aatttatgct cgtgtacaag     4860

tttgccagaa aacaccacat cactttaact aatctaatta ctgaagagac tactcatgtt     4920

gttatgaaaa cagatgctga gtttgtgtgt gaacggacac tgaaatattt tctaggaatt     4980

gcgggaggaa aatgggtagt tagctatttc tgggtgaccc agtctattaa agaaagaaaa     5040

atgctgaatg agcatgattt tgaagtcaga ggagatgtgg tcaatggaag aaaccaccaa     5100

ggtccaaagc gagcaagaga atcccaggac agaaagatct tcagggggct agaaatctgt     5160

tgctatgggc ccttcaccaa catgcccaca gatcaactgg aatggatggt acagctgtgt     5220

ggtgcttctg tggtgaagga gctttcatca ttcacccttg gcacaggtgt ccacccaatt     5280

gtggttgtgc agccagatgc ctggacagag gacaatggct tccatgcaat tgggcagatg     5340

tgtgaggcac ctgtggtgac ccgagagtgg gtgttggaca gtgtagcact ctaccagtgc     5400

caggagctgg acacctacct gataccccag atcccccaca gccactactg a              5451


<210>  17
<211>  1816
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu 
1               5                   10                  15      


Cys Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe 
            20                  25                  30          


Ser Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu 
        35                  40                  45              


Asp Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu 
    50                  55                  60                  


Asn Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser 
65                  70                  75                  80  


Met Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu 
                85                  90                  95      


Asn Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu 
            100                 105                 110         


Gly Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys 
        115                 120                 125             


Thr Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val 
    130                 135                 140                 


Asn Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile 
145                 150                 155                 160 


Thr Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys 
                165                 170                 175     


Ala Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His 
            180                 185                 190         


Gln Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu 
        195                 200                 205             


Arg His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val 
    210                 215                 220                 


Glu Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn 
225                 230                 235                 240 


Ser Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu 
                245                 250                 255     


Phe Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn 
            260                 265                 270         


Arg Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser 
        275                 280                 285             


Thr Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys 
    290                 295                 300                 


Glu Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr 
305                 310                 315                 320 


Glu Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn 
                325                 330                 335     


Glu Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His 
            340                 345                 350         


Asp Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val 
        355                 360                 365             


Leu Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu 
    370                 375                 380                 


Leu Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val 
385                 390                 395                 400 


His Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys 
                405                 410                 415     


Thr Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu 
            420                 425                 430         


Asn Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu 
        435                 440                 445             


Arg Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly 
    450                 455                 460                 


Leu His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys 
465                 470                 475                 480 


Thr Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly 
                485                 490                 495     


Gln Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly 
            500                 505                 510         


Asp Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu 
        515                 520                 525             


Lys Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile 
    530                 535                 540                 


Ser Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys 
545                 550                 555                 560 


Lys Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu 
                565                 570                 575     


Glu Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu 
            580                 585                 590         


Gln Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr 
        595                 600                 605             


Asn Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly 
    610                 615                 620                 


Lys Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln 
625                 630                 635                 640 


Thr Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr 
                645                 650                 655     


Asn Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys 
            660                 665                 670         


Glu Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu 
        675                 680                 685             


Glu Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met 
    690                 695                 700                 


Leu Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser 
705                 710                 715                 720 


Ser Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile 
                725                 730                 735     


Ser Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn 
            740                 745                 750         


Lys Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile 
        755                 760                 765             


His Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr 
    770                 775                 780                 


Pro Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met 
785                 790                 795                 800 


Glu Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val 
                805                 810                 815     


Ser Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu 
            820                 825                 830         


Glu Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln 
        835                 840                 845             


Ser Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly 
    850                 855                 860                 


Lys Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala 
865                 870                 875                 880 


Gly Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys 
                885                 890                 895     


Cys Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg 
            900                 905                 910         


Gly Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln 
        915                 920                 925             


Asn Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys 
    930                 935                 940                 


Thr Lys Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser 
945                 950                 955                 960 


Met Ser Pro Glu Arg Glu Met Gly Asn Glu Asn Ile Pro Ser Thr Val 
                965                 970                 975     


Ser Thr Ile Ser Arg Asn Asn Ile Arg Glu Asn Val Phe Lys Glu Ala 
            980                 985                 990         


Ser Ser Ser Asn Ile Asn Glu Val  Gly Ser Ser Thr Asn  Glu Val Gly 
        995                 1000                 1005             


Ser Ser  Ile Asn Glu Ile Gly  Ser Ser Asp Glu Asn  Ile Gln Ala 
    1010                 1015                 1020             


Glu Leu  Gly Arg Asn Arg Gly  Pro Lys Leu Asn Ala  Met Leu Arg 
    1025                 1030                 1035             


Leu Gly  Val Leu Gln Pro Glu  Val Tyr Lys Gln Ser  Leu Pro Gly 
    1040                 1045                 1050             


Ser Asn  Cys Lys His Pro Glu  Ile Lys Lys Gln Glu  Tyr Glu Glu 
    1055                 1060                 1065             


Val Val  Gln Thr Val Asn Thr  Asp Phe Ser Pro Tyr  Leu Ile Ser 
    1070                 1075                 1080             


Asp Asn  Leu Glu Gln Pro Met  Gly Ser Ser His Ala  Ser Gln Val 
    1085                 1090                 1095             


Cys Ser  Glu Thr Pro Asp Asp  Leu Leu Asp Asp Gly  Glu Ile Lys 
    1100                 1105                 1110             


Glu Asp  Thr Ser Phe Ala Glu  Asn Asp Ile Lys Glu  Ser Ser Ala 
    1115                 1120                 1125             


Val Phe  Ser Lys Ser Val Gln  Lys Gly Glu Leu Ser  Arg Ser Pro 
    1130                 1135                 1140             


Ser Pro  Phe Thr His Thr His  Leu Ala Gln Gly Tyr  Arg Arg Gly 
    1145                 1150                 1155             


Ala Lys  Lys Leu Glu Ser Ser  Glu Glu Asn Leu Ser  Ser Glu Asp 
    1160                 1165                 1170             


Glu Glu  Leu Pro Cys Phe Gln  His Leu Leu Phe Gly  Lys Val Asn 
    1175                 1180                 1185             


Asn Ile  Pro Ser Gln Ser Thr  Arg His Ser Thr Val  Ala Thr Glu 
    1190                 1195                 1200             


Cys Leu  Ser Lys Asn Thr Glu  Glu Asn Leu Leu Ser  Leu Lys Asn 
    1205                 1210                 1215             


Ser Leu  Asn Asp Cys Ser Asn  Gln Val Ile Leu Ala  Lys Ala Ser 
    1220                 1225                 1230             


Gln Glu  His His Leu Ser Glu  Glu Thr Lys Cys Ser  Ala Ser Leu 
    1235                 1240                 1245             


Phe Ser  Ser Gln Cys Ser Glu  Leu Glu Asp Leu Thr  Ala Asn Thr 
    1250                 1255                 1260             


Asn Thr  Gln Asp Pro Phe Leu  Ile Gly Ser Ser Lys  Gln Met Arg 
    1265                 1270                 1275             


His Gln  Ser Glu Ser Gln Gly  Val Gly Leu Ser Asp  Lys Glu Leu 
    1280                 1285                 1290             


Val Ser  Asp Asp Glu Glu Arg  Gly Thr Gly Leu Glu  Glu Asn Asn 
    1295                 1300                 1305             


Gln Glu  Glu Gln Ser Met Asp  Ser Asn Leu Gly Glu  Ala Ala Ser 
    1310                 1315                 1320             


Gly Cys  Glu Ser Glu Thr Ser  Val Ser Glu Asp Cys  Ser Gly Leu 
    1325                 1330                 1335             


Ser Ser  Gln Ser Asp Ile Leu  Thr Thr Gln Gln Arg  Asp Thr Met 
    1340                 1345                 1350             


Gln His  Asn Leu Ile Lys Leu  Gln Gln Glu Met Ala  Glu Leu Glu 
    1355                 1360                 1365             


Ala Val  Leu Glu Gln His Gly  Ser Gln Pro Ser Asn  Ser Tyr Pro 
    1370                 1375                 1380             


Ser Ile  Ile Ser Asp Ser Ser  Ala Leu Glu Asp Leu  Arg Asn Pro 
    1385                 1390                 1395             


Glu Gln  Ser Thr Ser Glu Lys  Ala Val Leu Thr Ser  Gln Lys Ser 
    1400                 1405                 1410             


Ser Glu  Tyr Pro Ile Ser Gln  Asn Pro Glu Gly Leu  Ser Ala Asp 
    1415                 1420                 1425             


Lys Phe  Glu Val Ser Ala Asp  Ser Ser Thr Ser Lys  Asn Lys Glu 
    1430                 1435                 1440             


Pro Gly  Val Glu Arg Ser Ser  Pro Ser Lys Cys Pro  Ser Leu Asp 
    1445                 1450                 1455             


Asp Arg  Trp Tyr Met His Ser  Cys Ser Gly Ser Leu  Gln Asn Arg 
    1460                 1465                 1470             


Asn Tyr  Pro Ser Gln Glu Glu  Leu Ile Lys Val Val  Asp Val Glu 
    1475                 1480                 1485             


Glu Gln  Gln Leu Glu Glu Ser  Gly Pro His Asp Leu  Thr Glu Thr 
    1490                 1495                 1500             


Ser Tyr  Leu Pro Arg Gln Asp  Leu Glu Gly Thr Pro  Tyr Leu Glu 
    1505                 1510                 1515             


Ser Gly  Ile Ser Leu Phe Ser  Asp Asp Pro Glu Ser  Asp Pro Ser 
    1520                 1525                 1530             


Glu Asp  Arg Ala Pro Glu Ser  Ala Arg Val Gly Asn  Ile Pro Ser 
    1535                 1540                 1545             


Ser Thr  Ser Ala Leu Lys Val  Pro Gln Leu Lys Val  Ala Glu Ser 
    1550                 1555                 1560             


Ala Gln  Ser Pro Ala Ala Ala  His Thr Thr Asp Thr  Ala Gly Tyr 
    1565                 1570                 1575             


Asn Ala  Met Glu Glu Ser Val  Ser Arg Glu Lys Pro  Glu Leu Thr 
    1580                 1585                 1590             


Ala Ser  Thr Glu Arg Val Asn  Lys Arg Met Ser Met  Val Val Ser 
    1595                 1600                 1605             


Gly Leu  Thr Pro Glu Glu Phe  Met Leu Val Tyr Lys  Phe Ala Arg 
    1610                 1615                 1620             


Lys His  His Ile Thr Leu Thr  Asn Leu Ile Thr Glu  Glu Thr Thr 
    1625                 1630                 1635             


His Val  Val Met Lys Thr Asp  Ala Glu Phe Val Cys  Glu Arg Thr 
    1640                 1645                 1650             


Leu Lys  Tyr Phe Leu Gly Ile  Ala Gly Gly Lys Trp  Val Val Ser 
    1655                 1660                 1665             


Tyr Phe  Trp Val Thr Gln Ser  Ile Lys Glu Arg Lys  Met Leu Asn 
    1670                 1675                 1680             


Glu His  Asp Phe Glu Val Arg  Gly Asp Val Val Asn  Gly Arg Asn 
    1685                 1690                 1695             


His Gln  Gly Pro Lys Arg Ala  Arg Glu Ser Gln Asp  Arg Lys Ile 
    1700                 1705                 1710             


Phe Arg  Gly Leu Glu Ile Cys  Cys Tyr Gly Pro Phe  Thr Asn Met 
    1715                 1720                 1725             


Pro Thr  Asp Gln Leu Glu Trp  Met Val Gln Leu Cys  Gly Ala Ser 
    1730                 1735                 1740             


Val Val  Lys Glu Leu Ser Ser  Phe Thr Leu Gly Thr  Gly Val His 
    1745                 1750                 1755             


Pro Ile  Val Val Val Gln Pro  Asp Ala Trp Thr Glu  Asp Asn Gly 
    1760                 1765                 1770             


Phe His  Ala Ile Gly Gln Met  Cys Glu Ala Pro Val  Val Thr Arg 
    1775                 1780                 1785             


Glu Trp  Val Leu Asp Ser Val  Ala Leu Tyr Gln Cys  Gln Glu Leu 
    1790                 1795                 1800             


Asp Thr  Tyr Leu Ile Pro Gln  Ile Pro His Ser His  Tyr 
    1805                 1810                 1815     


<210>  18
<211>  2280
<212>  DNA
<213>  Homo sapiens

<400>  18
atggatttat ctgctcttcg cgttgaagaa gtacaaaatg tcattaatgc tatgcagaaa       60

atcttagagt gtcccatctg tctggagttg atcaaggaac ctgtctccac aaagtgtgac      120

cacatatttt gcaaattttg catgctgaaa cttctcaacc agaagaaagg gccttcacag      180

tgtcctttat gtaagaatga tataaccaaa aggagcctac aagaaagtac gagatttagt      240

caacttgttg aagagctatt gaaaatcatt tgtgcttttc agcttgacac aggtttggag      300

tatgcaaaca gctataattt tgcaaaaaag gaaaataact ctcctgaaca tctaaaagat      360

gaagtttcta tcatccaaag tatgggctac agaaaccgtg ccaaaagact tctacagagt      420

gaacccgaaa atccttcctt gcaggaaacc agtctcagtg tccaactctc taaccttgga      480

actgtgagaa ctctgaggac aaagcagcgg atacaacctc aaaagacgtc tgtctacatt      540

gaattgggat ctgattcttc tgaagatacc gttaataagg caacttattg cagtgtggga      600

gatcaagaat tgttacaaat cacccctcaa ggaaccaggg atgaaatcag tttggattct      660

gcaaaaaagg ctgcttgtga attttctgag acggatgtaa caaatactga acatcatcaa      720

cccagtaata atgatttgaa caccactgag aagcgtgcag ctgagaggca tccagaaaag      780

tatcagggtg aagcagcatc tgggtgtgag agtgaaacaa gcgtctctga agactgctca      840

gggctatcct ctcagagtga cattttaacc actcagcaga gggataccat gcaacataac      900

ctgataaagc tccagcagga aatggctgaa ctagaagctg tgttagaaca gcatgggagc      960

cagccttcta acagctaccc ttccatcata agtgactctt ctgcccttga ggacctgcga     1020

aatccagaac aaagcacatc agaaaaagta ttaacttcac agaaaagtag tgaataccct     1080

ataagccaga atccagaagg cctttctgct gacaagtttg aggtgtctgc agatagttct     1140

accagtaaaa ataaagaacc aggagtggaa aggtcatccc cttctaaatg cccatcatta     1200

gatgataggt ggtacatgca cagttgctct gggagtcttc agaatagaaa ctacccatct     1260

caagaggagc tcattaaggt tgttgatgtg gaggagcaac agctggaaga gtctgggcca     1320

cacgatttga cggaaacatc ttacttgcca aggcaagatc tagagggaac cccttacctg     1380

gaatctggaa tcagcctctt ctctgatgac cctgaatctg atccttctga agacagagcc     1440

ccagagtcag ctcgtgttgg caacatacca tcttcaacct ctgcattgaa agttccccaa     1500

ttgaaagttg cagaatctgc ccagagtcca gctgctgctc atactactga tactgctggg     1560

tataatgcaa tggaagaaag tgtgagcagg gagaagccag aattgacagc ttcaacagaa     1620

agggtcaaca aaagaatgtc catggtggtg tctggcctga ccccagaaga atttatgctc     1680

gtgtacaagt ttgccagaaa acaccacatc actttaacta atctaattac tgaagagact     1740

actcatgttg ttatgaaaac agatgctgag tttgtgtgtg aacggacact gaaatatttt     1800

ctaggaattg cgggaggaaa atgggtagtt agctatttct gggtgaccca gtctattaaa     1860

gaaagaaaaa tgctgaatga gcatgatttt gaagtcagag gagatgtggt caatggaaga     1920

aaccaccaag gtccaaagcg agcaagagaa tcccaggaca gaaagatctt cagggggcta     1980

gaaatctgtt gctatgggcc cttcaccaac atgcccacag atcaactgga atggatggta     2040

cagctgtgtg gtgcttctgt ggtgaaggag ctttcatcat tcacccttgg cacaggtgtc     2100

cacccaattg tggttgtgca gccagatgcc tggacagagg acaatggctt ccatgcaatt     2160

gggcagatgt gtgaggcacc tgtggtgacc cgagagtggg tgttggacag tgtagcactc     2220

taccagtgcc aggagctgga cacctacctg ataccccaga tcccccacag ccactactga     2280


<210>  19
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu 
            260                 265                 270         


Thr Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile 
        275                 280                 285             


Leu Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu 
    290                 295                 300                 


Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser 
305                 310                 315                 320 


Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu 
                325                 330                 335     


Glu Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Val Leu Thr 
            340                 345                 350         


Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 
        355                 360                 365             


Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn 
    370                 375                 380                 


Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 
385                 390                 395                 400 


Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 
                405                 410                 415     


Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 
            420                 425                 430         


Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr Glu Thr Ser Tyr 
        435                 440                 445             


Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile 
    450                 455                 460                 


Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 
465                 470                 475                 480 


Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu 
                485                 490                 495     


Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala 
            500                 505                 510         


Ala His Thr Thr Asp Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 
        515                 520                 525             


Ser Arg Glu Lys Pro Glu Leu Thr Ala Ser Thr Glu Arg Val Asn Lys 
    530                 535                 540                 


Arg Met Ser Met Val Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu 
545                 550                 555                 560 


Val Tyr Lys Phe Ala Arg Lys His His Ile Thr Leu Thr Asn Leu Ile 
                565                 570                 575     


Thr Glu Glu Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe Val 
            580                 585                 590         


Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 
        595                 600                 605             


Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met 
    610                 615                 620                 


Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg 
625                 630                 635                 640 


Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile 
                645                 650                 655     


Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro 
            660                 665                 670         


Thr Asp Gln Leu Glu Trp Met Val Gln Leu Cys Gly Ala Ser Val Val 
        675                 680                 685             


Lys Glu Leu Ser Ser Phe Thr Leu Gly Thr Gly Val His Pro Ile Val 
    690                 695                 700                 


Val Val Gln Pro Asp Ala Trp Thr Glu Asp Asn Gly Phe His Ala Ile 
705                 710                 715                 720 


Gly Gln Met Cys Glu Ala Pro Val Val Thr Arg Glu Trp Val Leu Asp 
                725                 730                 735     


Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu Asp Thr Tyr Leu Ile Pro 
            740                 745                 750         


Gln Ile Pro His Ser His Tyr 
        755                 


<210>  20
<211>  2100
<212>  DNA
<213>  Homo sapiens

<400>  20
atggatttat ctgctcttcg cgttgaagaa gtacaaaatg tcattaatgc tatgcagaaa       60

atcttagagt gtcccatctg tctggagttg atcaaggaac ctgtctccac aaagtgtgac      120

cacatatttt gcaaattttg catgctgaaa cttctcaacc agaagaaagg gccttcacag      180

tgtcctttat gtaagaatga tataaccaaa aggagcctac aagaaagtac gagatttagt      240

caacttgttg aagagctatt gaaaatcatt tgtgcttttc agcttgacac aggtttggag      300

tatgcaaaca gctataattt tgcaaaaaag gaaaataact ctcctgaaca tctaaaagat      360

gaagtttcta tcatccaaag tatgggctac agaaaccgtg ccaaaagact tctacagagt      420

gaacccgaaa atccttcctt gcaggaaacc agtctcagtg tccaactctc taaccttgga      480

actgtgagaa ctctgaggac aaagcagcgg atacaacctc aaaagacgtc tgtctacatt      540

gaattgggat ctgattcttc tgaagatacc gttaataagg caacttattg cagtgtggga      600

gatcaagaat tgttacaaat cacccctcaa ggaaccaggg atgaaatcag tttggattct      660

gcaaaaaagg ctgcttgtga attttctgag acggatgtaa caaatactga acatcatcaa      720

cccagtaata atgatttgaa caccactgag aagcgtgcag ctgagaggca tccagaaaag      780

tatcagggtg aagcagcatc tgggtgtgag agtgaaacaa gcgtctctga agactgctca      840

gggctatcct ctcagagtga cattttaacc actcagcaga gggataccat gcaacataac      900

ctgataaagc tccagcagga aatggctgaa ctagaagctg tgttagaaca gcatgggagc      960

cagccttcta acagctaccc ttccatcata agtgactctt ctgcccttga ggacctgcga     1020

aatccagaac aaagcacatc agaaaaagta ttaacttcac agaaaagtag tgaataccct     1080

ataagccaga atccagaagg cctttctgct gacaagtttg aggtgtctgc agatagttct     1140

accagtaaaa ataaagaacc aggagtggaa aggtcatccc cttctaaatg cccatcatta     1200

gatgataggt ggtacatgca cagttgctct gggagtcttc agaatagaaa ctacccatct     1260

caagaggagc tcattaaggt tgttgatgtg gaggagcaac agctggaaga gtctgggcca     1320

cacgatttga cggaaacatc ttacttgcca aggcaagatc tagagggaac cccttacctg     1380

gaatctggaa tcagcctctt ctctgatgac cctgaatctg atccttctga agacagagcc     1440

ccagagtcag ctcgtgttgg caacatacca tcttcaacct ctgcattgaa agttccccaa     1500

ttgaaagttg cagaatctgc ccagagtcca gctgctgctc atactactga tactgctggg     1560

tataatgcaa tggaagaaag tgtgagcagg gagaagccag aattgacagc ttcaacagaa     1620

agggtcaaca aaagaatgtc catggtggtg tctggcctga ccccagaaga atttatgctc     1680

gtgtacaagt ttgccagaaa acaccacatc actttaacta atctaattac tgaagagact     1740

actcatgttg ttatgaaaac agatgctgag tttgtgtgtg aacggacact gaaatatttt     1800

ctaggaattg cgggaggaaa atgggtagtt agctatttct gggtgaccca gtctattaaa     1860

gaaagaaaaa tgctgaatga gcatgatttt gaagtcagag gagatgtggt caatggaaga     1920

aaccaccaag gtccaaagcg agcaagagaa tcccaggaca gaaagatctt cagggggcta     1980

gaaatctgtt gctatgggcc cttcaccaac atgcccacag ggtgtccacc caattgtggt     2040

tgtgcagcca gatgcctgga cagaggacaa tggcttccat gcaattgggc agatgtgtga     2100


<210>  21
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu 
            260                 265                 270         


Thr Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile 
        275                 280                 285             


Leu Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu 
    290                 295                 300                 


Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser 
305                 310                 315                 320 


Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu 
                325                 330                 335     


Glu Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Val Leu Thr 
            340                 345                 350         


Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 
        355                 360                 365             


Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn 
    370                 375                 380                 


Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 
385                 390                 395                 400 


Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 
                405                 410                 415     


Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 
            420                 425                 430         


Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr Glu Thr Ser Tyr 
        435                 440                 445             


Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile 
    450                 455                 460                 


Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 
465                 470                 475                 480 


Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu 
                485                 490                 495     


Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala 
            500                 505                 510         


Ala His Thr Thr Asp Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 
        515                 520                 525             


Ser Arg Glu Lys Pro Glu Leu Thr Ala Ser Thr Glu Arg Val Asn Lys 
    530                 535                 540                 


Arg Met Ser Met Val Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu 
545                 550                 555                 560 


Val Tyr Lys Phe Ala Arg Lys His His Ile Thr Leu Thr Asn Leu Ile 
                565                 570                 575     


Thr Glu Glu Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe Val 
            580                 585                 590         


Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 
        595                 600                 605             


Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met 
    610                 615                 620                 


Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg 
625                 630                 635                 640 


Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile 
                645                 650                 655     


Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro 
            660                 665                 670         


Thr Gly Cys Pro Pro Asn Cys Gly Cys Ala Ala Arg Cys Leu Asp Arg 
        675                 680                 685             


Gly Gln Trp Leu Pro Cys Asn Trp Ala Asp Val 
    690                 695                 


<210>  22
<211>  5655
<212>  DNA
<213>  Homo sapiens

<400>  22
atggatttat ctgctcttcg cgttgaagaa gtacaaaatg tcattaatgc tatgcagaaa       60

atcttagagt gtcccatctg tctggagttg atcaaggaac ctgtctccac aaagtgtgac      120

cacatatttt gcaaattttg catgctgaaa cttctcaacc agaagaaagg gccttcacag      180

tgtcctttat gtaagaatga tataaccaaa aggagcctac aagaaagtac gagatttagt      240

caacttgttg aagagctatt gaaaatcatt tgtgcttttc agcttgacac aggtttggag      300

tatgcaaaca gctataattt tgcaaaaaag gaaaataact ctcctgaaca tctaaaagat      360

gaagtttcta tcatccaaag tatgggctac agaaaccgtg ccaaaagact tctacagagt      420

gaacccgaaa atccttcctt gcaggaaacc agtctcagtg tccaactctc taaccttgga      480

actgtgagaa ctctgaggac aaagcagcgg atacaacctc aaaagacgtc tgtctacatt      540

gaattgggat ctgattcttc tgaagatacc gttaataagg caacttattg cagtgtggga      600

gatcaagaat tgttacaaat cacccctcaa ggaaccaggg atgaaatcag tttggattct      660

gcaaaaaagg ctgcttgtga attttctgag acggatgtaa caaatactga acatcatcaa      720

cccagtaata atgatttgaa caccactgag aagcgtgcag ctgagaggca tccagaaaag      780

tatcagggta gttctgtttc aaacttgcat gtggagccat gtggcacaaa tactcatgcc      840

agctcattac agcatgagaa cagcagttta ttactcacta aagacagaat gaatgtagaa      900

aaggctgaat tctgtaataa aagcaaacag cctggcttag caaggagcca acataacaga      960

tgggctggaa gtaaggaaac atgtaatgat aggcggactc ccagcacaga aaaaaaggta     1020

gatctgaatg ctgatcccct gtgtgagaga aaagaatgga ataagcagaa actgccatgc     1080

tcagagaatc ctagagatac tgaagatgtt ccttggataa cactaaatag cagcattcag     1140

aaagttaatg agtggttttc cagaagtgat gaactgttag gttctgatga ctcacatgat     1200

ggggagtctg aatcaaatgc caaagtagct gatgtattgg acgttctaaa tgaggtagat     1260

gaatattctg gttcttcaga gaaaatagac ttactggcca gtgatcctca tgaggcttta     1320

atatgtaaaa gtgaaagagt tcactccaaa tcagtagaga gtaatattga agacaaaata     1380

tttgggaaaa cctatcggaa gaaggcaagc ctccccaact taagccatgt aactgaaaat     1440

ctaattatag gagcatttgt tactgagcca cagataatac aagagcgtcc cctcacaaat     1500

aaattaaagc gtaaaaggag acctacatca ggccttcatc ctgaggattt tatcaagaaa     1560

gcagatttgg cagttcaaaa gactcctgaa atgataaatc agggaactaa ccaaacggag     1620

cagaatggtc aagtgatgaa tattactaat agtggtcatg agaataaaac aaaaggtgat     1680

tctattcaga atgagaaaaa tcctaaccca atagaatcac tcgaaaaaga atctgctttc     1740

aaaacgaaag ctgaacctat aagcagcagt ataagcaata tggaactcga attaaatatc     1800

cacaattcaa aagcacctaa aaagaatagg ctgaggagga agtcttctac caggcatatt     1860

catgcgcttg aactagtagt cagtagaaat ctaagcccac ctaattgtac tgaattgcaa     1920

attgatagtt gttctagcag tgaagagata aagaaaaaaa agtacaacca aatgccagtc     1980

aggcacagca gaaacctaca actcatggaa ggtaaagaac ctgcaactgg agccaagaag     2040

agtaacaagc caaatgaaca gacaagtaaa agacatgaca gcgatacttt cccagagctg     2100

aagttaacaa atgcacctgg ttcttttact aagtgttcaa ataccagtga acttaaagaa     2160

tttgtcaatc ctagccttcc aagagaagaa aaagaagaga aactagaaac agttaaagtg     2220

tctaataatg ctgaagaccc caaagatctc atgttaagtg gagaaagggt tttgcaaact     2280

gaaagatctg tagagagtag cagtatttca ttggtacctg gtactgatta tggcactcag     2340

gaaagtatct cgttactgga agttagcact ctagggaagg caaaaacaga accaaataaa     2400

tgtgtgagtc agtgtgcagc atttgaaaac cccaagggac taattcatgg ttgttccaaa     2460

gataatagaa atgacacaga aggctttaag tatccattgg gacatgaagt taaccacagt     2520

cgggaaacaa gcatagaaat ggaagaaagt gaacttgatg ctcagtattt gcagaataca     2580

ttcaaggttt caaagcgcca gtcatttgct ccgttttcaa atccaggaaa tgcagaagag     2640

gaatgtgcaa cattctctgc ccactctggg tccttaaaga aacaaagtcc aaaagtcact     2700

tttgaatgtg aacaaaagga agaaaatcaa ggaaagaatg agtctaatat caagcctgta     2760

cagacagtta atatcactgc aggctttcct gtggttggtc agaaagataa gccagttgat     2820

aatgccaaat gtagtatcaa aggaggctct aggttttgtc tatcatctca gttcagaggc     2880

aacgaaactg gactcattac tccaaataaa catggacttt tacaaaaccc atatcgtata     2940

ccaccacttt ttcccatcaa gtcatttgtt aaaactaaat gtaagaaaaa tctgctagag     3000

gaaaactttg aggaacattc aatgtcacct gaaagagaaa tgggaaatga gaacattcca     3060

agtacagtga gcacaattag ccgtaataac attagagaaa atgtttttaa agaagccagc     3120

tcaagcaata ttaatgaagt aggttccagt actaatgaag tgggctccag tattaatgaa     3180

ataggttcca gtgatgaaaa cattcaagca gaactaggta gaaacagagg gccaaaattg     3240

aatgctatgc ttagattagg ggttttgcaa cctgaggtct ataaacaaag tcttcctgga     3300

agtaattgta agcatcctga aataaaaaag caagaatatg aagaagtagt tcagactgtt     3360

aatacagatt tctctccata tctgatttca gataacttag aacagcctat gggaagtagt     3420

catgcatctc aggtttgttc tgagacacct gatgacctgt tagatgatgg tgaaataaag     3480

gaagatacta gttttgctga aaatgacatt aaggaaagtt ctgctgtttt tagcaaaagc     3540

gtccagaaag gagagcttag caggagtcct agccctttca cccatacaca tttggctcag     3600

ggttaccgaa gaggggccaa gaaattagag tcctcagaag agaacttatc tagtgaggat     3660

gaagagcttc cctgcttcca acacttgtta tttggtaaag taaacaatat accttctcag     3720

tctactaggc atagcaccgt tgctaccgag tgtctgtcta agaacacaga ggagaattta     3780

ttatcattga agaatagctt aaatgactgc agtaaccagg taatattggc aaaggcatct     3840

caggaacatc accttagtga ggaaacaaaa tgttctgcta gcttgttttc ttcacagtgc     3900

agtgaattgg aagacttgac tgcaaataca aacacccagg atcctttctt gattggttct     3960

tccaaacaaa tgaggcatca gtctgaaagc cagggagttg gtctgagtga caaggaattg     4020

gtttcagatg atgaagaaag aggaacgggc ttggaagaaa ataatcaaga agagcaaagc     4080

atggattcaa acttaggtga agcagcatct gggtgtgaga gtgaaacaag cgtctctgaa     4140

gactgctcag ggctatcctc tcagagtgac attttaacca ctcagcagag ggataccatg     4200

caacataacc tgataaagct ccagcaggaa atggctgaac tagaagctgt gttagaacag     4260

catgggagcc agccttctaa cagctaccct tccatcataa gtgactcttc tgcccttgag     4320

gacctgcgaa atccagaaca aagcacatca gaaaaagatt cgcatataca tggccaaagg     4380

aacaactcca tgttttctaa aaggcctaga gaacatatat cagtattaac ttcacagaaa     4440

agtagtgaat accctataag ccagaatcca gaaggccttt ctgctgacaa gtttgaggtg     4500

tctgcagata gttctaccag taaaaataaa gaaccaggag tggaaaggtc atccccttct     4560

aaatgcccat cattagatga taggtggtac atgcacagtt gctctgggag tcttcagaat     4620

agaaactacc catctcaaga ggagctcatt aaggttgttg atgtggagga gcaacagctg     4680

gaagagtctg ggccacacga tttgacggaa acatcttact tgccaaggca agatctagag     4740

ggaacccctt acctggaatc tggaatcagc ctcttctctg atgaccctga atctgatcct     4800

tctgaagaca gagccccaga gtcagctcgt gttggcaaca taccatcttc aacctctgca     4860

ttgaaagttc cccaattgaa agttgcagaa tctgcccaga gtccagctgc tgctcatact     4920

actgatactg ctgggtataa tgcaatggaa gaaagtgtga gcagggagaa gccagaattg     4980

acagcttcaa cagaaagggt caacaaaaga atgtccatgg tggtgtctgg cctgacccca     5040

gaagaattta tgctcgtgta caagtttgcc agaaaacacc acatcacttt aactaatcta     5100

attactgaag agactactca tgttgttatg aaaacagatg ctgagtttgt gtgtgaacgg     5160

acactgaaat attttctagg aattgcggga ggaaaatggg tagttagcta tttctgggtg     5220

acccagtcta ttaaagaaag aaaaatgctg aatgagcatg attttgaagt cagaggagat     5280

gtggtcaatg gaagaaacca ccaaggtcca aagcgagcaa gagaatccca ggacagaaag     5340

atcttcaggg ggctagaaat ctgttgctat gggcccttca ccaacatgcc cacagatcaa     5400

ctggaatgga tggtacagct gtgtggtgct tctgtggtga aggagctttc atcattcacc     5460

cttggcacag gtgtccaccc aattgtggtt gtgcagccag atgcctggac agaggacaat     5520

ggcttccatg caattgggca gatgtgtgag gcacctgtgg tgacccgaga gtgggtgttg     5580

gacagtgtag cactctacca gtgccaggag ctggacacct acctgatacc ccagatcccc     5640

cacagccact actga                                                      5655


<210>  23
<211>  1884
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Asp Ser His  Ile His Gly 
    1445                 1450                 1455             


Gln Arg  Asn Asn Ser Met Phe  Ser Lys Arg Pro Arg  Glu His Ile 
    1460                 1465                 1470             


Ser Val  Leu Thr Ser Gln Lys  Ser Ser Glu Tyr Pro  Ile Ser Gln 
    1475                 1480                 1485             


Asn Pro  Glu Gly Leu Ser Ala  Asp Lys Phe Glu Val  Ser Ala Asp 
    1490                 1495                 1500             


Ser Ser  Thr Ser Lys Asn Lys  Glu Pro Gly Val Glu  Arg Ser Ser 
    1505                 1510                 1515             


Pro Ser  Lys Cys Pro Ser Leu  Asp Asp Arg Trp Tyr  Met His Ser 
    1520                 1525                 1530             


Cys Ser  Gly Ser Leu Gln Asn  Arg Asn Tyr Pro Ser  Gln Glu Glu 
    1535                 1540                 1545             


Leu Ile  Lys Val Val Asp Val  Glu Glu Gln Gln Leu  Glu Glu Ser 
    1550                 1555                 1560             


Gly Pro  His Asp Leu Thr Glu  Thr Ser Tyr Leu Pro  Arg Gln Asp 
    1565                 1570                 1575             


Leu Glu  Gly Thr Pro Tyr Leu  Glu Ser Gly Ile Ser  Leu Phe Ser 
    1580                 1585                 1590             


Asp Asp  Pro Glu Ser Asp Pro  Ser Glu Asp Arg Ala  Pro Glu Ser 
    1595                 1600                 1605             


Ala Arg  Val Gly Asn Ile Pro  Ser Ser Thr Ser Ala  Leu Lys Val 
    1610                 1615                 1620             


Pro Gln  Leu Lys Val Ala Glu  Ser Ala Gln Ser Pro  Ala Ala Ala 
    1625                 1630                 1635             


His Thr  Thr Asp Thr Ala Gly  Tyr Asn Ala Met Glu  Glu Ser Val 
    1640                 1645                 1650             


Ser Arg  Glu Lys Pro Glu Leu  Thr Ala Ser Thr Glu  Arg Val Asn 
    1655                 1660                 1665             


Lys Arg  Met Ser Met Val Val  Ser Gly Leu Thr Pro  Glu Glu Phe 
    1670                 1675                 1680             


Met Leu  Val Tyr Lys Phe Ala  Arg Lys His His Ile  Thr Leu Thr 
    1685                 1690                 1695             


Asn Leu  Ile Thr Glu Glu Thr  Thr His Val Val Met  Lys Thr Asp 
    1700                 1705                 1710             


Ala Glu  Phe Val Cys Glu Arg  Thr Leu Lys Tyr Phe  Leu Gly Ile 
    1715                 1720                 1725             


Ala Gly  Gly Lys Trp Val Val  Ser Tyr Phe Trp Val  Thr Gln Ser 
    1730                 1735                 1740             


Ile Lys  Glu Arg Lys Met Leu  Asn Glu His Asp Phe  Glu Val Arg 
    1745                 1750                 1755             


Gly Asp  Val Val Asn Gly Arg  Asn His Gln Gly Pro  Lys Arg Ala 
    1760                 1765                 1770             


Arg Glu  Ser Gln Asp Arg Lys  Ile Phe Arg Gly Leu  Glu Ile Cys 
    1775                 1780                 1785             


Cys Tyr  Gly Pro Phe Thr Asn  Met Pro Thr Asp Gln  Leu Glu Trp 
    1790                 1795                 1800             


Met Val  Gln Leu Cys Gly Ala  Ser Val Val Lys Glu  Leu Ser Ser 
    1805                 1810                 1815             


Phe Thr  Leu Gly Thr Gly Val  His Pro Ile Val Val  Val Gln Pro 
    1820                 1825                 1830             


Asp Ala  Trp Thr Glu Asp Asn  Gly Phe His Ala Ile  Gly Gln Met 
    1835                 1840                 1845             


Cys Glu  Ala Pro Val Val Thr  Arg Glu Trp Val Leu  Asp Ser Val 
    1850                 1855                 1860             


Ala Leu  Tyr Gln Cys Gln Glu  Leu Asp Thr Tyr Leu  Ile Pro Gln 
    1865                 1870                 1875             


Ile Pro  His Ser His Tyr 
    1880                 


<210>  24
<211>  10257
<212>  DNA
<213>  Homo sapiens

<400>  24
atgcctattg gatccaaaga gaggccaaca ttttttgaaa tttttaagac acgctgcaac       60

aaagcagatt taggaccaat aagtcttaat tggtttgaag aactttcttc agaagctcca      120

ccctataatt ctgaacctgc agaagaatct gaacataaaa acaacaatta cgaaccaaac      180

ctatttaaaa ctccacaaag gaaaccatct tataatcagc tggcttcaac tccaataata      240

ttcaaagagc aagggctgac tctgccgctg taccaatctc ctgtaaaaga attagataaa      300

ttcaaattag acttaggaag gaatgttccc aatagtagac ataaaagtct tcgcacagtg      360

aaaactaaaa tggatcaagc agatgatgtt tcctgtccac ttctaaattc ttgtcttagt      420

gaaagtcctg ttgttctaca atgtacacat gtaacaccac aaagagataa gtcagtggta      480

tgtgggagtt tgtttcatac accaaagttt gtgaagggtc gtcagacacc aaaacatatt      540

tctgaaagtc taggagctga ggtggatcct gatatgtctt ggtcaagttc tttagctaca      600

ccacccaccc ttagttctac tgtgctcata gtcagaaatg aagaagcatc tgaaactgta      660

tttcctcatg atactactgc taatgtgaaa agctattttt ccaatcatga tgaaagtctg      720

aagaaaaatg atagatttat cgcttctgtg acagacagtg aaaacacaaa tcaaagagaa      780

gctgcaagtc atggatttgg aaaaacatca gggaattcat ttaaagtaaa tagctgcaaa      840

gaccacattg gaaagtcaat gccaaatgtc ctagaagatg aagtatatga aacagttgta      900

gatacctctg aagaagatag tttttcatta tgtttttcta aatgtagaac aaaaaatcta      960

caaaaagtaa gaactagcaa gactaggaaa aaaattttcc atgaagcaaa cgctgatgaa     1020

tgtgaaaaat ctaaaaacca agtgaaagaa aaatactcat ttgtatctga agtggaacca     1080

aatgatactg atccattaga ttcaaatgta gcaaatcaga agccctttga gagtggaagt     1140

gacaaaatct ccaaggaagt tgtaccgtct ttggcctgtg aatggtctca actaaccctt     1200

tcaggtctaa atggagccca gatggagaaa atacccctat tgcatatttc ttcatgtgac     1260

caaaatattt cagaaaaaga cctattagac acagagaaca aaagaaagaa agattttctt     1320

acttcagaga attctttgcc acgtatttct agcctaccaa aatcagagaa gccattaaat     1380

gaggaaacag tggtaaataa gagagatgaa gagcagcatc ttgaatctca tacagactgc     1440

attcttgcag taaagcaggc aatatctgga acttctccag tggcttcttc atttcagggt     1500

atcaaaaagt ctatattcag aataagagaa tcacctaaag agactttcaa tgcaagtttt     1560

tcaggtcata tgactgatcc aaactttaaa aaagaaactg aagcctctga aagtggactg     1620

gaaatacata ctgtttgctc acagaaggag gactccttat gtccaaattt aattgataat     1680

ggaagctggc cagccaccac cacacagaat tctgtagctt tgaagaatgc aggtttaata     1740

tccactttga aaaagaaaac aaataagttt atttatgcta tacatgatga aacatcttat     1800

aaaggaaaaa aaataccgaa agaccaaaaa tcagaactaa ttaactgttc agcccagttt     1860

gaagcaaatg cttttgaagc accacttaca tttgcaaatg ctgattcagg tttattgcat     1920

tcttctgtga aaagaagctg ttcacagaat gattctgaag aaccaacttt gtccttaact     1980

agctcttttg ggacaattct gaggaaatgt tctagaaatg aaacatgttc taataataca     2040

gtaatctctc aggatcttga ttataaagaa gcaaaatgta ataaggaaaa actacagtta     2100

tttattaccc cagaagctga ttctctgtca tgcctgcagg aaggacagtg tgaaaatgat     2160

ccaaaaagca aaaaagtttc agatataaaa gaagaggtct tggctgcagc atgtcaccca     2220

gtacaacatt caaaagtgga atacagtgat actgactttc aatcccagaa aagtctttta     2280

tatgatcatg aaaatgccag cactcttatt ttaactccta cttccaagga tgttctgtca     2340

aacctagtca tgatttctag aggcaaagaa tcatacaaaa tgtcagacaa gctcaaaggt     2400

aacaattatg aatctgatgt tgaattaacc aaaaatattc ccatggaaaa gaatcaagat     2460

gtatgtgctt taaatgaaaa ttataaaaac gttgagctgt tgccacctga aaaatacatg     2520

agagtagcat caccttcaag aaaggtacaa ttcaaccaaa acacaaatct aagagtaatc     2580

caaaaaaatc aagaagaaac tacttcaatt tcaaaaataa ctgtcaatcc agactctgaa     2640

gaacttttct cagacaatga gaataatttt gtcttccaag tagctaatga aaggaataat     2700

cttgctttag gaaatactaa ggaacttcat gaaacagact tgacttgtgt aaacgaaccc     2760

attttcaaga actctaccat ggttttatat ggagacacag gtgataaaca agcaacccaa     2820

gtgtcaatta aaaaagattt ggtttatgtt cttgcagagg agaacaaaaa tagtgtaaag     2880

cagcatataa aaatgactct aggtcaagat ttaaaatcgg acatctcctt gaatatagat     2940

aaaataccag aaaaaaataa tgattacatg aacaaatggg caggactctt aggtccaatt     3000

tcaaatcaca gttttggagg tagcttcaga acagcttcaa ataaggaaat caagctctct     3060

gaacataaca ttaagaagag caaaatgttc ttcaaagata ttgaagaaca atatcctact     3120

agtttagctt gtgttgaaat tgtaaatacc ttggcattag ataatcaaaa gaaactgagc     3180

aagcctcagt caattaatac tgtatctgca catttacaga gtagtgtagt tgtttctgat     3240

tgtaaaaata gtcatataac ccctcagatg ttattttcca agcaggattt taattcaaac     3300

cataatttaa cacctagcca aaaggcagaa attacagaac tttctactat attagaagaa     3360

tcaggaagtc agtttgaatt tactcagttt agaaaaccaa gctacatatt gcagaagagt     3420

acatttgaag tgcctgaaaa ccagatgact atcttaaaga ccacttctga ggaatgcaga     3480

gatgctgatc ttcatgtcat aatgaatgcc ccatcgattg gtcaggtaga cagcagcaag     3540

caatttgaag gtacagttga aattaaacgg aagtttgctg gcctgttgaa aaatgactgt     3600

aacaaaagtg cttctggtta tttaacagat gaaaatgaag tggggtttag gggcttttat     3660

tctgctcatg gcacaaaact gaatgtttct actgaagctc tgcaaaaagc tgtgaaactg     3720

tttagtgata ttgagaatat tagtgaggaa acttctgcag aggtacatcc aataagttta     3780

tcttcaagta aatgtcatga ttctgttgtt tcaatgttta agatagaaaa tcataatgat     3840

aaaactgtaa gtgaaaaaaa taataaatgc caactgatat tacaaaataa tattgaaatg     3900

actactggca cttttgttga agaaattact gaaaattaca agagaaatac tgaaaatgaa     3960

gataacaaat atactgctgc cagtagaaat tctcataact tagaatttga tggcagtgat     4020

tcaagtaaaa atgatactgt ttgtattcat aaagatgaaa cggacttgct atttactgat     4080

cagcacaaca tatgtcttaa attatctggc cagtttatga aggagggaaa cactcagatt     4140

aaagaagatt tgtcagattt aacttttttg gaagttgcga aagctcaaga agcatgtcat     4200

ggtaatactt caaataaaga acagttaact gctactaaaa cggagcaaaa tataaaagat     4260

tttgagactt ctgatacatt ttttcagact gcaagtggga aaaatattag tgtcgccaaa     4320

gagtcattta ataaaattgt aaatttcttt gatcagaaac cagaagaatt gcataacttt     4380

tccttaaatt ctgaattaca ttctgacata agaaagaaca aaatggacat tctaagttat     4440

gaggaaacag acatagttaa acacaaaata ctgaaagaaa gtgtcccagt tggtactgga     4500

aatcaactag tgaccttcca gggacaaccc gaacgtgatg aaaagatcaa agaacctact     4560

ctattgggtt ttcatacagc tagcgggaaa aaagttaaaa ttgcaaagga atctttggac     4620

aaagtgaaaa acctttttga tgaaaaagag caaggtacta gtgaaatcac cagttttagc     4680

catcaatggg caaagaccct aaagtacaga gaggcctgta aagaccttga attagcatgt     4740

gagaccattg agatcacagc tgccccaaag tgtaaagaaa tgcagaattc tctcaataat     4800

gataaaaacc ttgtttctat tgagactgtg gtgccaccta agctcttaag tgataattta     4860

tgtagacaaa ctgaaaatct caaaacatca aaaagtatct ttttgaaagt taaagtacat     4920

gaaaatgtag aaaaagaaac agcaaaaagt cctgcaactt gttacacaaa tcagtcccct     4980

tattcagtca ttgaaaattc agccttagct ttttacacaa gttgtagtag aaaaacttct     5040

gtgagtcaga cttcattact tgaagcaaaa aaatggctta gagaaggaat atttgatggt     5100

caaccagaaa gaataaatac tgcagattat gtaggaaatt atttgtatga aaataattca     5160

aacagtacta tagctgaaaa tgacaaaaat catctctccg aaaaacaaga tacttattta     5220

agtaacagta gcatgtctaa cagctattcc taccattctg atgaggtata taatgattca     5280

ggatatctct caaaaaataa acttgattct ggtattgagc cagtattgaa gaatgttgaa     5340

gatcaaaaaa acactagttt ttccaaagta atatccaatg taaaagatgc aaatgcatac     5400

ccacaaactg taaatgaaga tatttgcgtt gaggaacttg tgactagctc ttcaccctgc     5460

aaaaataaaa atgcagccat taaattgtcc atatctaata gtaataattt tgaggtaggg     5520

ccacctgcat ttaggatagc cagtggtaaa atcgtttgtg tttcacatga aacaattaaa     5580

aaagtgaaag acatatttac agacagtttc agtaaagtaa ttaaggaaaa caacgagaat     5640

aaatcaaaaa tttgccaaac gaaaattatg gcaggttgtt acgaggcatt ggatgattca     5700

gaggatattc ttcataactc tctagataat gatgaatgta gcacgcattc acataaggtt     5760

tttgctgaca ttcagagtga agaaatttta caacataacc aaaatatgtc tggattggag     5820

aaagtttcta aaatatcacc ttgtgatgtt agtttggaaa cttcagatat atgtaaatgt     5880

agtataggga agcttcataa gtcagtctca tctgcaaata cttgtgggat ttttagcaca     5940

gcaagtggaa aatctgtcca ggtatcagat gcttcattac aaaacgcaag acaagtgttt     6000

tctgaaatag aagatagtac caagcaagtc ttttccaaag tattgtttaa aagtaacgaa     6060

cattcagacc agctcacaag agaagaaaat actgctatac gtactccaga acatttaata     6120

tcccaaaaag gcttttcata taatgtggta aattcatctg ctttctctgg atttagtaca     6180

gcaagtggaa agcaagtttc cattttagaa agttccttac acaaagttaa gggagtgtta     6240

gaggaatttg atttaatcag aactgagcat agtcttcact attcacctac gtctagacaa     6300

aatgtatcaa aaatacttcc tcgtgttgat aagagaaacc cagagcactg tgtaaactca     6360

gaaatggaaa aaacctgcag taaagaattt aaattatcaa ataacttaaa tgttgaaggt     6420

ggttcttcag aaaataatca ctctattaaa gtttctccat atctctctca atttcaacaa     6480

gacaaacaac agttggtatt aggaaccaaa gtgtcacttg ttgagaacat tcatgttttg     6540

ggaaaagaac aggcttcacc taaaaacgta aaaatggaaa ttggtaaaac tgaaactttt     6600

tctgatgttc ctgtgaaaac aaatatagaa gtttgttcta cttactccaa agattcagaa     6660

aactactttg aaacagaagc agtagaaatt gctaaagctt ttatggaaga tgatgaactg     6720

acagattcta aactgccaag tcatgccaca cattctcttt ttacatgtcc cgaaaatgag     6780

gaaatggttt tgtcaaattc aagaattgga aaaagaagag gagagcccct tatcttagtg     6840

ggagaaccct caatcaaaag aaacttatta aatgaatttg acaggataat agaaaatcaa     6900

gaaaaatcct taaaggcttc aaaaagcact ccagatggca caataaaaga tcgaagattg     6960

tttatgcatc atgtttcttt agagccgatt acctgtgtac cctttcgcac aactaaggaa     7020

cgtcaagaga tacagaatcc aaattttacc gcacctggtc aagaatttct gtctaaatct     7080

catttgtatg aacatctgac tttggaaaaa tcttcaagca atttagcagt ttcaggacat     7140

ccattttatc aagtttctgc tacaagaaat gaaaaaatga gacacttgat tactacaggc     7200

agaccaacca aagtctttgt tccacctttt aaaactaaat cacattttca cagagttgaa     7260

cagtgtgtta ggaatattaa cttggaggaa aacagacaaa agcaaaacat tgatggacat     7320

ggctctgatg atagtaaaaa taagattaat gacaatgaga ttcatcagtt taacaaaaac     7380

aactccaatc aagcagtagc tgtaactttc acaaagtgtg aagaagaacc tttagattta     7440

attacaagtc ttcagaatgc cagagatata caggatatgc gaattaagaa gaaacaaagg     7500

caacgcgtct ttccacagcc aggcagtctg tatcttgcaa aaacatccac tctgcctcga     7560

atctctctga aagcagcagt aggaggccaa gttccctctg cgtgttctca taaacagctg     7620

tatacgtatg gcgtttctaa acattgcata aaaattaaca gcaaaaatgc agagtctttt     7680

cagtttcaca ctgaagatta ttttggtaag gaaagtttat ggactggaaa aggaatacag     7740

ttggctgatg gtggatggct cataccctcc aatgatggaa aggctggaaa agaagaattt     7800

tatagggctc tgtgtgacac tccaggtgtg gatccaaagc ttatttctag aatttgggtt     7860

tataatcact atagatggat catatggaaa ctggcagcta tggaatgtgc ctttcctaag     7920

gaatttgcta atagatgcct aagcccagaa agggtgcttc ttcaactaaa atacagatat     7980

gatacggaaa ttgatagaag cagaagatcg gctataaaaa agataatgga aagggatgac     8040

acagctgcaa aaacacttgt tctctgtgtt tctgacataa tttcattgag cgcaaatata     8100

tctgaaactt ctagcaataa aactagtagt gcagataccc aaaaagtggc cattattgaa     8160

cttacagatg ggtggtatgc tgttaaggcc cagttagatc ctcccctctt agctgtctta     8220

aagaatggca gactgacagt tggtcagaag attattcttc atggagcaga actggtgggc     8280

tctcctgatg cctgtacacc tcttgaagcc ccagaatctc ttatgttaaa gatttctgct     8340

aacagtactc ggcctgctcg ctggtatacc aaacttggat tctttcctga ccctagacct     8400

tttcctctgc ccttatcatc gcttttcagt gatggaggaa atgttggttg tgttgatgta     8460

attattcaaa gagcataccc tatacagtgg atggagaaga catcatctgg attatacata     8520

tttcgcaatg aaagagagga agaaaaggaa gcagcaaaat atgtggaggc ccaacaaaag     8580

agactagaag ccttattcac taaaattcag gaggaatttg aagaacatga agaaaacaca     8640

acaaaaccat atttaccatc acgtgcacta acaagacagc aagttcgtgc tttgcaagat     8700

ggtgcagagc tttatgaagc agtgaagaat gcagcagacc cagcttacct tgagggttat     8760

ttcagtgaag agcagttaag agccttgaat aatcacaggc aaatgttgaa tgataagaaa     8820

caagctcaga tccagttgga aattaggaag gccatggaat ctgctgaaca aaaggaacaa     8880

ggtttatcaa gggatgtcac aaccgtgtgg aagttgcgta ttgtaagcta ttcaaaaaaa     8940

gaaaaagatt cagttatact gagtatttgg cgtccatcat cagatttata ttctctgtta     9000

acagaaggaa agagatacag aatttatcat cttgcaactt caaaatctaa aagtaaatct     9060

gaaagagcta acatacagtt agcagcgaca aaaaaaactc agtatcaaca actaccggtt     9120

tcagatgaaa ttttatttca gatttaccag ccacgggagc cccttcactt cagcaaattt     9180

ttagatccag actttcagcc atcttgttct gaggtggacc taataggatt tgtcgtttct     9240

gttgtgaaaa aaacaggact tgcccctttc gtctatttgt cagacgaatg ttacaattta     9300

ctggcaataa agttttggat agaccttaat gaggacatta ttaagcctca tatgttaatt     9360

gctgcaagca acctccagtg gcgaccagaa tccaaatcag gccttcttac tttatttgct     9420

ggagattttt ctgtgttttc tgctagtcca aaagagggcc actttcaaga gacattcaac     9480

aaaatgaaaa atactgttga gaatattgac atactttgca atgaagcaga aaacaagctt     9540

atgcatatac tgcatgcaaa tgatcccaag tggtccaccc caactaaaga ctgtacttca     9600

gggccgtaca ctgctcaaat cattcctggt acaggaaaca agcttctgat gtcttctcct     9660

aattgtgaga tatattatca aagtccttta tcactttgta tggccaaaag gaagtctgtt     9720

tccacacctg tctcagccca gatgacttca aagtcttgta aaggggagaa agagattgat     9780

gaccaaaaga actgcaaaaa gagaagagcc ttggatttct tgagtagact gcctttacct     9840

ccacctgtta gtcccatttg tacatttgtt tctccggctg cacagaaggc atttcagcca     9900

ccaaggagtt gtggcaccaa atacgaaaca cccataaaga aaaaagaact gaattctcct     9960

cagatgactc catttaaaaa attcaatgaa atttctcttt tggaaagtaa ttcaatagct    10020

gacgaagaac ttgcattgat aaatacccaa gctcttttgt ctggttcaac aggagaaaaa    10080

caatttatat ctgtcagtga atccactagg actgctccca ccagttcaga agattatctc    10140

agactgaaac gacgttgtac tacatctctg atcaaagaac aggagagttc ccaggccagt    10200

acggaagaat gtgagaaaaa taagcaggac acaattacaa ctaaaaaata tatctaa       10257


<210>  25
<211>  3418
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Pro Ile Gly Ser Lys Glu Arg Pro Thr Phe Phe Glu Ile Phe Lys 
1               5                   10                  15      


Thr Arg Cys Asn Lys Ala Asp Leu Gly Pro Ile Ser Leu Asn Trp Phe 
            20                  25                  30          


Glu Glu Leu Ser Ser Glu Ala Pro Pro Tyr Asn Ser Glu Pro Ala Glu 
        35                  40                  45              


Glu Ser Glu His Lys Asn Asn Asn Tyr Glu Pro Asn Leu Phe Lys Thr 
    50                  55                  60                  


Pro Gln Arg Lys Pro Ser Tyr Asn Gln Leu Ala Ser Thr Pro Ile Ile 
65                  70                  75                  80  


Phe Lys Glu Gln Gly Leu Thr Leu Pro Leu Tyr Gln Ser Pro Val Lys 
                85                  90                  95      


Glu Leu Asp Lys Phe Lys Leu Asp Leu Gly Arg Asn Val Pro Asn Ser 
            100                 105                 110         


Arg His Lys Ser Leu Arg Thr Val Lys Thr Lys Met Asp Gln Ala Asp 
        115                 120                 125             


Asp Val Ser Cys Pro Leu Leu Asn Ser Cys Leu Ser Glu Ser Pro Val 
    130                 135                 140                 


Val Leu Gln Cys Thr His Val Thr Pro Gln Arg Asp Lys Ser Val Val 
145                 150                 155                 160 


Cys Gly Ser Leu Phe His Thr Pro Lys Phe Val Lys Gly Arg Gln Thr 
                165                 170                 175     


Pro Lys His Ile Ser Glu Ser Leu Gly Ala Glu Val Asp Pro Asp Met 
            180                 185                 190         


Ser Trp Ser Ser Ser Leu Ala Thr Pro Pro Thr Leu Ser Ser Thr Val 
        195                 200                 205             


Leu Ile Val Arg Asn Glu Glu Ala Ser Glu Thr Val Phe Pro His Asp 
    210                 215                 220                 


Thr Thr Ala Asn Val Lys Ser Tyr Phe Ser Asn His Asp Glu Ser Leu 
225                 230                 235                 240 


Lys Lys Asn Asp Arg Phe Ile Ala Ser Val Thr Asp Ser Glu Asn Thr 
                245                 250                 255     


Asn Gln Arg Glu Ala Ala Ser His Gly Phe Gly Lys Thr Ser Gly Asn 
            260                 265                 270         


Ser Phe Lys Val Asn Ser Cys Lys Asp His Ile Gly Lys Ser Met Pro 
        275                 280                 285             


Asn Val Leu Glu Asp Glu Val Tyr Glu Thr Val Val Asp Thr Ser Glu 
    290                 295                 300                 


Glu Asp Ser Phe Ser Leu Cys Phe Ser Lys Cys Arg Thr Lys Asn Leu 
305                 310                 315                 320 


Gln Lys Val Arg Thr Ser Lys Thr Arg Lys Lys Ile Phe His Glu Ala 
                325                 330                 335     


Asn Ala Asp Glu Cys Glu Lys Ser Lys Asn Gln Val Lys Glu Lys Tyr 
            340                 345                 350         


Ser Phe Val Ser Glu Val Glu Pro Asn Asp Thr Asp Pro Leu Asp Ser 
        355                 360                 365             


Asn Val Ala Asn Gln Lys Pro Phe Glu Ser Gly Ser Asp Lys Ile Ser 
    370                 375                 380                 


Lys Glu Val Val Pro Ser Leu Ala Cys Glu Trp Ser Gln Leu Thr Leu 
385                 390                 395                 400 


Ser Gly Leu Asn Gly Ala Gln Met Glu Lys Ile Pro Leu Leu His Ile 
                405                 410                 415     


Ser Ser Cys Asp Gln Asn Ile Ser Glu Lys Asp Leu Leu Asp Thr Glu 
            420                 425                 430         


Asn Lys Arg Lys Lys Asp Phe Leu Thr Ser Glu Asn Ser Leu Pro Arg 
        435                 440                 445             


Ile Ser Ser Leu Pro Lys Ser Glu Lys Pro Leu Asn Glu Glu Thr Val 
    450                 455                 460                 


Val Asn Lys Arg Asp Glu Glu Gln His Leu Glu Ser His Thr Asp Cys 
465                 470                 475                 480 


Ile Leu Ala Val Lys Gln Ala Ile Ser Gly Thr Ser Pro Val Ala Ser 
                485                 490                 495     


Ser Phe Gln Gly Ile Lys Lys Ser Ile Phe Arg Ile Arg Glu Ser Pro 
            500                 505                 510         


Lys Glu Thr Phe Asn Ala Ser Phe Ser Gly His Met Thr Asp Pro Asn 
        515                 520                 525             


Phe Lys Lys Glu Thr Glu Ala Ser Glu Ser Gly Leu Glu Ile His Thr 
    530                 535                 540                 


Val Cys Ser Gln Lys Glu Asp Ser Leu Cys Pro Asn Leu Ile Asp Asn 
545                 550                 555                 560 


Gly Ser Trp Pro Ala Thr Thr Thr Gln Asn Ser Val Ala Leu Lys Asn 
                565                 570                 575     


Ala Gly Leu Ile Ser Thr Leu Lys Lys Lys Thr Asn Lys Phe Ile Tyr 
            580                 585                 590         


Ala Ile His Asp Glu Thr Ser Tyr Lys Gly Lys Lys Ile Pro Lys Asp 
        595                 600                 605             


Gln Lys Ser Glu Leu Ile Asn Cys Ser Ala Gln Phe Glu Ala Asn Ala 
    610                 615                 620                 


Phe Glu Ala Pro Leu Thr Phe Ala Asn Ala Asp Ser Gly Leu Leu His 
625                 630                 635                 640 


Ser Ser Val Lys Arg Ser Cys Ser Gln Asn Asp Ser Glu Glu Pro Thr 
                645                 650                 655     


Leu Ser Leu Thr Ser Ser Phe Gly Thr Ile Leu Arg Lys Cys Ser Arg 
            660                 665                 670         


Asn Glu Thr Cys Ser Asn Asn Thr Val Ile Ser Gln Asp Leu Asp Tyr 
        675                 680                 685             


Lys Glu Ala Lys Cys Asn Lys Glu Lys Leu Gln Leu Phe Ile Thr Pro 
    690                 695                 700                 


Glu Ala Asp Ser Leu Ser Cys Leu Gln Glu Gly Gln Cys Glu Asn Asp 
705                 710                 715                 720 


Pro Lys Ser Lys Lys Val Ser Asp Ile Lys Glu Glu Val Leu Ala Ala 
                725                 730                 735     


Ala Cys His Pro Val Gln His Ser Lys Val Glu Tyr Ser Asp Thr Asp 
            740                 745                 750         


Phe Gln Ser Gln Lys Ser Leu Leu Tyr Asp His Glu Asn Ala Ser Thr 
        755                 760                 765             


Leu Ile Leu Thr Pro Thr Ser Lys Asp Val Leu Ser Asn Leu Val Met 
    770                 775                 780                 


Ile Ser Arg Gly Lys Glu Ser Tyr Lys Met Ser Asp Lys Leu Lys Gly 
785                 790                 795                 800 


Asn Asn Tyr Glu Ser Asp Val Glu Leu Thr Lys Asn Ile Pro Met Glu 
                805                 810                 815     


Lys Asn Gln Asp Val Cys Ala Leu Asn Glu Asn Tyr Lys Asn Val Glu 
            820                 825                 830         


Leu Leu Pro Pro Glu Lys Tyr Met Arg Val Ala Ser Pro Ser Arg Lys 
        835                 840                 845             


Val Gln Phe Asn Gln Asn Thr Asn Leu Arg Val Ile Gln Lys Asn Gln 
    850                 855                 860                 


Glu Glu Thr Thr Ser Ile Ser Lys Ile Thr Val Asn Pro Asp Ser Glu 
865                 870                 875                 880 


Glu Leu Phe Ser Asp Asn Glu Asn Asn Phe Val Phe Gln Val Ala Asn 
                885                 890                 895     


Glu Arg Asn Asn Leu Ala Leu Gly Asn Thr Lys Glu Leu His Glu Thr 
            900                 905                 910         


Asp Leu Thr Cys Val Asn Glu Pro Ile Phe Lys Asn Ser Thr Met Val 
        915                 920                 925             


Leu Tyr Gly Asp Thr Gly Asp Lys Gln Ala Thr Gln Val Ser Ile Lys 
    930                 935                 940                 


Lys Asp Leu Val Tyr Val Leu Ala Glu Glu Asn Lys Asn Ser Val Lys 
945                 950                 955                 960 


Gln His Ile Lys Met Thr Leu Gly Gln Asp Leu Lys Ser Asp Ile Ser 
                965                 970                 975     


Leu Asn Ile Asp Lys Ile Pro Glu Lys Asn Asn Asp Tyr Met Asn Lys 
            980                 985                 990         


Trp Ala Gly Leu Leu Gly Pro Ile  Ser Asn His Ser Phe  Gly Gly Ser 
        995                 1000                 1005             


Phe Arg  Thr Ala Ser Asn Lys  Glu Ile Lys Leu Ser  Glu His Asn 
    1010                 1015                 1020             


Ile Lys  Lys Ser Lys Met Phe  Phe Lys Asp Ile Glu  Glu Gln Tyr 
    1025                 1030                 1035             


Pro Thr  Ser Leu Ala Cys Val  Glu Ile Val Asn Thr  Leu Ala Leu 
    1040                 1045                 1050             


Asp Asn  Gln Lys Lys Leu Ser  Lys Pro Gln Ser Ile  Asn Thr Val 
    1055                 1060                 1065             


Ser Ala  His Leu Gln Ser Ser  Val Val Val Ser Asp  Cys Lys Asn 
    1070                 1075                 1080             


Ser His  Ile Thr Pro Gln Met  Leu Phe Ser Lys Gln  Asp Phe Asn 
    1085                 1090                 1095             


Ser Asn  His Asn Leu Thr Pro  Ser Gln Lys Ala Glu  Ile Thr Glu 
    1100                 1105                 1110             


Leu Ser  Thr Ile Leu Glu Glu  Ser Gly Ser Gln Phe  Glu Phe Thr 
    1115                 1120                 1125             


Gln Phe  Arg Lys Pro Ser Tyr  Ile Leu Gln Lys Ser  Thr Phe Glu 
    1130                 1135                 1140             


Val Pro  Glu Asn Gln Met Thr  Ile Leu Lys Thr Thr  Ser Glu Glu 
    1145                 1150                 1155             


Cys Arg  Asp Ala Asp Leu His  Val Ile Met Asn Ala  Pro Ser Ile 
    1160                 1165                 1170             


Gly Gln  Val Asp Ser Ser Lys  Gln Phe Glu Gly Thr  Val Glu Ile 
    1175                 1180                 1185             


Lys Arg  Lys Phe Ala Gly Leu  Leu Lys Asn Asp Cys  Asn Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Tyr Leu Thr Asp  Glu Asn Glu Val Gly  Phe Arg Gly 
    1205                 1210                 1215             


Phe Tyr  Ser Ala His Gly Thr  Lys Leu Asn Val Ser  Thr Glu Ala 
    1220                 1225                 1230             


Leu Gln  Lys Ala Val Lys Leu  Phe Ser Asp Ile Glu  Asn Ile Ser 
    1235                 1240                 1245             


Glu Glu  Thr Ser Ala Glu Val  His Pro Ile Ser Leu  Ser Ser Ser 
    1250                 1255                 1260             


Lys Cys  His Asp Ser Val Val  Ser Met Phe Lys Ile  Glu Asn His 
    1265                 1270                 1275             


Asn Asp  Lys Thr Val Ser Glu  Lys Asn Asn Lys Cys  Gln Leu Ile 
    1280                 1285                 1290             


Leu Gln  Asn Asn Ile Glu Met  Thr Thr Gly Thr Phe  Val Glu Glu 
    1295                 1300                 1305             


Ile Thr  Glu Asn Tyr Lys Arg  Asn Thr Glu Asn Glu  Asp Asn Lys 
    1310                 1315                 1320             


Tyr Thr  Ala Ala Ser Arg Asn  Ser His Asn Leu Glu  Phe Asp Gly 
    1325                 1330                 1335             


Ser Asp  Ser Ser Lys Asn Asp  Thr Val Cys Ile His  Lys Asp Glu 
    1340                 1345                 1350             


Thr Asp  Leu Leu Phe Thr Asp  Gln His Asn Ile Cys  Leu Lys Leu 
    1355                 1360                 1365             


Ser Gly  Gln Phe Met Lys Glu  Gly Asn Thr Gln Ile  Lys Glu Asp 
    1370                 1375                 1380             


Leu Ser  Asp Leu Thr Phe Leu  Glu Val Ala Lys Ala  Gln Glu Ala 
    1385                 1390                 1395             


Cys His  Gly Asn Thr Ser Asn  Lys Glu Gln Leu Thr  Ala Thr Lys 
    1400                 1405                 1410             


Thr Glu  Gln Asn Ile Lys Asp  Phe Glu Thr Ser Asp  Thr Phe Phe 
    1415                 1420                 1425             


Gln Thr  Ala Ser Gly Lys Asn  Ile Ser Val Ala Lys  Glu Ser Phe 
    1430                 1435                 1440             


Asn Lys  Ile Val Asn Phe Phe  Asp Gln Lys Pro Glu  Glu Leu His 
    1445                 1450                 1455             


Asn Phe  Ser Leu Asn Ser Glu  Leu His Ser Asp Ile  Arg Lys Asn 
    1460                 1465                 1470             


Lys Met  Asp Ile Leu Ser Tyr  Glu Glu Thr Asp Ile  Val Lys His 
    1475                 1480                 1485             


Lys Ile  Leu Lys Glu Ser Val  Pro Val Gly Thr Gly  Asn Gln Leu 
    1490                 1495                 1500             


Val Thr  Phe Gln Gly Gln Pro  Glu Arg Asp Glu Lys  Ile Lys Glu 
    1505                 1510                 1515             


Pro Thr  Leu Leu Gly Phe His  Thr Ala Ser Gly Lys  Lys Val Lys 
    1520                 1525                 1530             


Ile Ala  Lys Glu Ser Leu Asp  Lys Val Lys Asn Leu  Phe Asp Glu 
    1535                 1540                 1545             


Lys Glu  Gln Gly Thr Ser Glu  Ile Thr Ser Phe Ser  His Gln Trp 
    1550                 1555                 1560             


Ala Lys  Thr Leu Lys Tyr Arg  Glu Ala Cys Lys Asp  Leu Glu Leu 
    1565                 1570                 1575             


Ala Cys  Glu Thr Ile Glu Ile  Thr Ala Ala Pro Lys  Cys Lys Glu 
    1580                 1585                 1590             


Met Gln  Asn Ser Leu Asn Asn  Asp Lys Asn Leu Val  Ser Ile Glu 
    1595                 1600                 1605             


Thr Val  Val Pro Pro Lys Leu  Leu Ser Asp Asn Leu  Cys Arg Gln 
    1610                 1615                 1620             


Thr Glu  Asn Leu Lys Thr Ser  Lys Ser Ile Phe Leu  Lys Val Lys 
    1625                 1630                 1635             


Val His  Glu Asn Val Glu Lys  Glu Thr Ala Lys Ser  Pro Ala Thr 
    1640                 1645                 1650             


Cys Tyr  Thr Asn Gln Ser Pro  Tyr Ser Val Ile Glu  Asn Ser Ala 
    1655                 1660                 1665             


Leu Ala  Phe Tyr Thr Ser Cys  Ser Arg Lys Thr Ser  Val Ser Gln 
    1670                 1675                 1680             


Thr Ser  Leu Leu Glu Ala Lys  Lys Trp Leu Arg Glu  Gly Ile Phe 
    1685                 1690                 1695             


Asp Gly  Gln Pro Glu Arg Ile  Asn Thr Ala Asp Tyr  Val Gly Asn 
    1700                 1705                 1710             


Tyr Leu  Tyr Glu Asn Asn Ser  Asn Ser Thr Ile Ala  Glu Asn Asp 
    1715                 1720                 1725             


Lys Asn  His Leu Ser Glu Lys  Gln Asp Thr Tyr Leu  Ser Asn Ser 
    1730                 1735                 1740             


Ser Met  Ser Asn Ser Tyr Ser  Tyr His Ser Asp Glu  Val Tyr Asn 
    1745                 1750                 1755             


Asp Ser  Gly Tyr Leu Ser Lys  Asn Lys Leu Asp Ser  Gly Ile Glu 
    1760                 1765                 1770             


Pro Val  Leu Lys Asn Val Glu  Asp Gln Lys Asn Thr  Ser Phe Ser 
    1775                 1780                 1785             


Lys Val  Ile Ser Asn Val Lys  Asp Ala Asn Ala Tyr  Pro Gln Thr 
    1790                 1795                 1800             


Val Asn  Glu Asp Ile Cys Val  Glu Glu Leu Val Thr  Ser Ser Ser 
    1805                 1810                 1815             


Pro Cys  Lys Asn Lys Asn Ala  Ala Ile Lys Leu Ser  Ile Ser Asn 
    1820                 1825                 1830             


Ser Asn  Asn Phe Glu Val Gly  Pro Pro Ala Phe Arg  Ile Ala Ser 
    1835                 1840                 1845             


Gly Lys  Ile Val Cys Val Ser  His Glu Thr Ile Lys  Lys Val Lys 
    1850                 1855                 1860             


Asp Ile  Phe Thr Asp Ser Phe  Ser Lys Val Ile Lys  Glu Asn Asn 
    1865                 1870                 1875             


Glu Asn  Lys Ser Lys Ile Cys  Gln Thr Lys Ile Met  Ala Gly Cys 
    1880                 1885                 1890             


Tyr Glu  Ala Leu Asp Asp Ser  Glu Asp Ile Leu His  Asn Ser Leu 
    1895                 1900                 1905             


Asp Asn  Asp Glu Cys Ser Thr  His Ser His Lys Val  Phe Ala Asp 
    1910                 1915                 1920             


Ile Gln  Ser Glu Glu Ile Leu  Gln His Asn Gln Asn  Met Ser Gly 
    1925                 1930                 1935             


Leu Glu  Lys Val Ser Lys Ile  Ser Pro Cys Asp Val  Ser Leu Glu 
    1940                 1945                 1950             


Thr Ser  Asp Ile Cys Lys Cys  Ser Ile Gly Lys Leu  His Lys Ser 
    1955                 1960                 1965             


Val Ser  Ser Ala Asn Thr Cys  Gly Ile Phe Ser Thr  Ala Ser Gly 
    1970                 1975                 1980             


Lys Ser  Val Gln Val Ser Asp  Ala Ser Leu Gln Asn  Ala Arg Gln 
    1985                 1990                 1995             


Val Phe  Ser Glu Ile Glu Asp  Ser Thr Lys Gln Val  Phe Ser Lys 
    2000                 2005                 2010             


Val Leu  Phe Lys Ser Asn Glu  His Ser Asp Gln Leu  Thr Arg Glu 
    2015                 2020                 2025             


Glu Asn  Thr Ala Ile Arg Thr  Pro Glu His Leu Ile  Ser Gln Lys 
    2030                 2035                 2040             


Gly Phe  Ser Tyr Asn Val Val  Asn Ser Ser Ala Phe  Ser Gly Phe 
    2045                 2050                 2055             


Ser Thr  Ala Ser Gly Lys Gln  Val Ser Ile Leu Glu  Ser Ser Leu 
    2060                 2065                 2070             


His Lys  Val Lys Gly Val Leu  Glu Glu Phe Asp Leu  Ile Arg Thr 
    2075                 2080                 2085             


Glu His  Ser Leu His Tyr Ser  Pro Thr Ser Arg Gln  Asn Val Ser 
    2090                 2095                 2100             


Lys Ile  Leu Pro Arg Val Asp  Lys Arg Asn Pro Glu  His Cys Val 
    2105                 2110                 2115             


Asn Ser  Glu Met Glu Lys Thr  Cys Ser Lys Glu Phe  Lys Leu Ser 
    2120                 2125                 2130             


Asn Asn  Leu Asn Val Glu Gly  Gly Ser Ser Glu Asn  Asn His Ser 
    2135                 2140                 2145             


Ile Lys  Val Ser Pro Tyr Leu  Ser Gln Phe Gln Gln  Asp Lys Gln 
    2150                 2155                 2160             


Gln Leu  Val Leu Gly Thr Lys  Val Ser Leu Val Glu  Asn Ile His 
    2165                 2170                 2175             


Val Leu  Gly Lys Glu Gln Ala  Ser Pro Lys Asn Val  Lys Met Glu 
    2180                 2185                 2190             


Ile Gly  Lys Thr Glu Thr Phe  Ser Asp Val Pro Val  Lys Thr Asn 
    2195                 2200                 2205             


Ile Glu  Val Cys Ser Thr Tyr  Ser Lys Asp Ser Glu  Asn Tyr Phe 
    2210                 2215                 2220             


Glu Thr  Glu Ala Val Glu Ile  Ala Lys Ala Phe Met  Glu Asp Asp 
    2225                 2230                 2235             


Glu Leu  Thr Asp Ser Lys Leu  Pro Ser His Ala Thr  His Ser Leu 
    2240                 2245                 2250             


Phe Thr  Cys Pro Glu Asn Glu  Glu Met Val Leu Ser  Asn Ser Arg 
    2255                 2260                 2265             


Ile Gly  Lys Arg Arg Gly Glu  Pro Leu Ile Leu Val  Gly Glu Pro 
    2270                 2275                 2280             


Ser Ile  Lys Arg Asn Leu Leu  Asn Glu Phe Asp Arg  Ile Ile Glu 
    2285                 2290                 2295             


Asn Gln  Glu Lys Ser Leu Lys  Ala Ser Lys Ser Thr  Pro Asp Gly 
    2300                 2305                 2310             


Thr Ile  Lys Asp Arg Arg Leu  Phe Met His His Val  Ser Leu Glu 
    2315                 2320                 2325             


Pro Ile  Thr Cys Val Pro Phe  Arg Thr Thr Lys Glu  Arg Gln Glu 
    2330                 2335                 2340             


Ile Gln  Asn Pro Asn Phe Thr  Ala Pro Gly Gln Glu  Phe Leu Ser 
    2345                 2350                 2355             


Lys Ser  His Leu Tyr Glu His  Leu Thr Leu Glu Lys  Ser Ser Ser 
    2360                 2365                 2370             


Asn Leu  Ala Val Ser Gly His  Pro Phe Tyr Gln Val  Ser Ala Thr 
    2375                 2380                 2385             


Arg Asn  Glu Lys Met Arg His  Leu Ile Thr Thr Gly  Arg Pro Thr 
    2390                 2395                 2400             


Lys Val  Phe Val Pro Pro Phe  Lys Thr Lys Ser His  Phe His Arg 
    2405                 2410                 2415             


Val Glu  Gln Cys Val Arg Asn  Ile Asn Leu Glu Glu  Asn Arg Gln 
    2420                 2425                 2430             


Lys Gln  Asn Ile Asp Gly His  Gly Ser Asp Asp Ser  Lys Asn Lys 
    2435                 2440                 2445             


Ile Asn  Asp Asn Glu Ile His  Gln Phe Asn Lys Asn  Asn Ser Asn 
    2450                 2455                 2460             


Gln Ala  Val Ala Val Thr Phe  Thr Lys Cys Glu Glu  Glu Pro Leu 
    2465                 2470                 2475             


Asp Leu  Ile Thr Ser Leu Gln  Asn Ala Arg Asp Ile  Gln Asp Met 
    2480                 2485                 2490             


Arg Ile  Lys Lys Lys Gln Arg  Gln Arg Val Phe Pro  Gln Pro Gly 
    2495                 2500                 2505             


Ser Leu  Tyr Leu Ala Lys Thr  Ser Thr Leu Pro Arg  Ile Ser Leu 
    2510                 2515                 2520             


Lys Ala  Ala Val Gly Gly Gln  Val Pro Ser Ala Cys  Ser His Lys 
    2525                 2530                 2535             


Gln Leu  Tyr Thr Tyr Gly Val  Ser Lys His Cys Ile  Lys Ile Asn 
    2540                 2545                 2550             


Ser Lys  Asn Ala Glu Ser Phe  Gln Phe His Thr Glu  Asp Tyr Phe 
    2555                 2560                 2565             


Gly Lys  Glu Ser Leu Trp Thr  Gly Lys Gly Ile Gln  Leu Ala Asp 
    2570                 2575                 2580             


Gly Gly  Trp Leu Ile Pro Ser  Asn Asp Gly Lys Ala  Gly Lys Glu 
    2585                 2590                 2595             


Glu Phe  Tyr Arg Ala Leu Cys  Asp Thr Pro Gly Val  Asp Pro Lys 
    2600                 2605                 2610             


Leu Ile  Ser Arg Ile Trp Val  Tyr Asn His Tyr Arg  Trp Ile Ile 
    2615                 2620                 2625             


Trp Lys  Leu Ala Ala Met Glu  Cys Ala Phe Pro Lys  Glu Phe Ala 
    2630                 2635                 2640             


Asn Arg  Cys Leu Ser Pro Glu  Arg Val Leu Leu Gln  Leu Lys Tyr 
    2645                 2650                 2655             


Arg Tyr  Asp Thr Glu Ile Asp  Arg Ser Arg Arg Ser  Ala Ile Lys 
    2660                 2665                 2670             


Lys Ile  Met Glu Arg Asp Asp  Thr Ala Ala Lys Thr  Leu Val Leu 
    2675                 2680                 2685             


Cys Val  Ser Asp Ile Ile Ser  Leu Ser Ala Asn Ile  Ser Glu Thr 
    2690                 2695                 2700             


Ser Ser  Asn Lys Thr Ser Ser  Ala Asp Thr Gln Lys  Val Ala Ile 
    2705                 2710                 2715             


Ile Glu  Leu Thr Asp Gly Trp  Tyr Ala Val Lys Ala  Gln Leu Asp 
    2720                 2725                 2730             


Pro Pro  Leu Leu Ala Val Leu  Lys Asn Gly Arg Leu  Thr Val Gly 
    2735                 2740                 2745             


Gln Lys  Ile Ile Leu His Gly  Ala Glu Leu Val Gly  Ser Pro Asp 
    2750                 2755                 2760             


Ala Cys  Thr Pro Leu Glu Ala  Pro Glu Ser Leu Met  Leu Lys Ile 
    2765                 2770                 2775             


Ser Ala  Asn Ser Thr Arg Pro  Ala Arg Trp Tyr Thr  Lys Leu Gly 
    2780                 2785                 2790             


Phe Phe  Pro Asp Pro Arg Pro  Phe Pro Leu Pro Leu  Ser Ser Leu 
    2795                 2800                 2805             


Phe Ser  Asp Gly Gly Asn Val  Gly Cys Val Asp Val  Ile Ile Gln 
    2810                 2815                 2820             


Arg Ala  Tyr Pro Ile Gln Trp  Met Glu Lys Thr Ser  Ser Gly Leu 
    2825                 2830                 2835             


Tyr Ile  Phe Arg Asn Glu Arg  Glu Glu Glu Lys Glu  Ala Ala Lys 
    2840                 2845                 2850             


Tyr Val  Glu Ala Gln Gln Lys  Arg Leu Glu Ala Leu  Phe Thr Lys 
    2855                 2860                 2865             


Ile Gln  Glu Glu Phe Glu Glu  His Glu Glu Asn Thr  Thr Lys Pro 
    2870                 2875                 2880             


Tyr Leu  Pro Ser Arg Ala Leu  Thr Arg Gln Gln Val  Arg Ala Leu 
    2885                 2890                 2895             


Gln Asp  Gly Ala Glu Leu Tyr  Glu Ala Val Lys Asn  Ala Ala Asp 
    2900                 2905                 2910             


Pro Ala  Tyr Leu Glu Gly Tyr  Phe Ser Glu Glu Gln  Leu Arg Ala 
    2915                 2920                 2925             


Leu Asn  Asn His Arg Gln Met  Leu Asn Asp Lys Lys  Gln Ala Gln 
    2930                 2935                 2940             


Ile Gln  Leu Glu Ile Arg Lys  Ala Met Glu Ser Ala  Glu Gln Lys 
    2945                 2950                 2955             


Glu Gln  Gly Leu Ser Arg Asp  Val Thr Thr Val Trp  Lys Leu Arg 
    2960                 2965                 2970             


Ile Val  Ser Tyr Ser Lys Lys  Glu Lys Asp Ser Val  Ile Leu Ser 
    2975                 2980                 2985             


Ile Trp  Arg Pro Ser Ser Asp  Leu Tyr Ser Leu Leu  Thr Glu Gly 
    2990                 2995                 3000             


Lys Arg  Tyr Arg Ile Tyr His  Leu Ala Thr Ser Lys  Ser Lys Ser 
    3005                 3010                 3015             


Lys Ser  Glu Arg Ala Asn Ile  Gln Leu Ala Ala Thr  Lys Lys Thr 
    3020                 3025                 3030             


Gln Tyr  Gln Gln Leu Pro Val  Ser Asp Glu Ile Leu  Phe Gln Ile 
    3035                 3040                 3045             


Tyr Gln  Pro Arg Glu Pro Leu  His Phe Ser Lys Phe  Leu Asp Pro 
    3050                 3055                 3060             


Asp Phe  Gln Pro Ser Cys Ser  Glu Val Asp Leu Ile  Gly Phe Val 
    3065                 3070                 3075             


Val Ser  Val Val Lys Lys Thr  Gly Leu Ala Pro Phe  Val Tyr Leu 
    3080                 3085                 3090             


Ser Asp  Glu Cys Tyr Asn Leu  Leu Ala Ile Lys Phe  Trp Ile Asp 
    3095                 3100                 3105             


Leu Asn  Glu Asp Ile Ile Lys  Pro His Met Leu Ile  Ala Ala Ser 
    3110                 3115                 3120             


Asn Leu  Gln Trp Arg Pro Glu  Ser Lys Ser Gly Leu  Leu Thr Leu 
    3125                 3130                 3135             


Phe Ala  Gly Asp Phe Ser Val  Phe Ser Ala Ser Pro  Lys Glu Gly 
    3140                 3145                 3150             


His Phe  Gln Glu Thr Phe Asn  Lys Met Lys Asn Thr  Val Glu Asn 
    3155                 3160                 3165             


Ile Asp  Ile Leu Cys Asn Glu  Ala Glu Asn Lys Leu  Met His Ile 
    3170                 3175                 3180             


Leu His  Ala Asn Asp Pro Lys  Trp Ser Thr Pro Thr  Lys Asp Cys 
    3185                 3190                 3195             


Thr Ser  Gly Pro Tyr Thr Ala  Gln Ile Ile Pro Gly  Thr Gly Asn 
    3200                 3205                 3210             


Lys Leu  Leu Met Ser Ser Pro  Asn Cys Glu Ile Tyr  Tyr Gln Ser 
    3215                 3220                 3225             


Pro Leu  Ser Leu Cys Met Ala  Lys Arg Lys Ser Val  Ser Thr Pro 
    3230                 3235                 3240             


Val Ser  Ala Gln Met Thr Ser  Lys Ser Cys Lys Gly  Glu Lys Glu 
    3245                 3250                 3255             


Ile Asp  Asp Gln Lys Asn Cys  Lys Lys Arg Arg Ala  Leu Asp Phe 
    3260                 3265                 3270             


Leu Ser  Arg Leu Pro Leu Pro  Pro Pro Val Ser Pro  Ile Cys Thr 
    3275                 3280                 3285             


Phe Val  Ser Pro Ala Ala Gln  Lys Ala Phe Gln Pro  Pro Arg Ser 
    3290                 3295                 3300             


Cys Gly  Thr Lys Tyr Glu Thr  Pro Ile Lys Lys Lys  Glu Leu Asn 
    3305                 3310                 3315             


Ser Pro  Gln Met Thr Pro Phe  Lys Lys Phe Asn Glu  Ile Ser Leu 
    3320                 3325                 3330             


Leu Glu  Ser Asn Ser Ile Ala  Asp Glu Glu Leu Ala  Leu Ile Asn 
    3335                 3340                 3345             


Thr Gln  Ala Leu Leu Ser Gly  Ser Thr Gly Glu Lys  Gln Phe Ile 
    3350                 3355                 3360             


Ser Val  Ser Glu Ser Thr Arg  Thr Ala Pro Thr Ser  Ser Glu Asp 
    3365                 3370                 3375             


Tyr Leu  Arg Leu Lys Arg Arg  Cys Thr Thr Ser Leu  Ile Lys Glu 
    3380                 3385                 3390             


Gln Glu  Ser Ser Gln Ala Ser  Thr Glu Glu Cys Glu  Lys Asn Lys 
    3395                 3400                 3405             


Gln Asp  Thr Ile Thr Thr Lys  Lys Tyr Ile 
    3410                 3415             


<210>  26
<211>  1881
<212>  DNA
<213>  Homo sapiens

<400>  26
atgcagcgag ccgattccga gcagccctcc aagcgtcccc gttgcgatga cagcccgaga       60

accccctcaa acaccccttc cgcagaggca gactggtccc cgggcctgga actccatccc      120

gactacaaga catggggtcc ggagcaggtg tgctccttcc tcaggcgcgg tggctttgaa      180

gagccggtgc tgctgaagaa catccgagaa aatgaaatca caggcgcatt actgccttgt      240

cttgatgagt ctcgttttga aaatcttgga gtaagttcct tgggggagag gaagaagctg      300

cttagttata tccagcgatt ggttcaaatc cacgttgata caatgaaggt aattaatgat      360

cctatccatg gccacattga gctccaccct ctcctcgtcc gaatcattga tacacctcaa      420

tttcaacgtc ttcgatacat caaacagctg ggaggtggtt actatgtttt tccaggagct      480

tcacacaatc gatttgagca tagtctaggg gtggggtatc tagcaggatg tctagttcac      540

gcactgggtg aaaaacaacc agagctgcag ataagtgaac gagatgttct ctgtgttcag      600

attgctggac tttgtcatga tctcggtcat gggccatttt ctcacatgtt tgatggacga      660

tttattccac ttgctcgccc ggaggtgaaa tggacgcatg aacaaggctc agttatgatg      720

tttgagcacc ttattaattc taatggaatt aagcctgtca tggaacaata tggtctcatc      780

cctgaagaag atatttgctt tataaaggaa caaattgtag gaccacttga atcacctgtc      840

gaagattcat tgtggccata taaagggcgt cctgaaaaca aaagcttcct ttatgagata      900

gtatctaata aaagaaatgg cattgatgtg gacaaatggg attattttgc cagggactgc      960

catcatcttg gaatccaaaa taattttgat tacaagcgct ttattaagtt tgcccgtgtc     1020

tgtgaagtag acaatgagtt gcgtatttgt gctagagata aggaagttgg aaatctgtat     1080

gacatgttcc acactcgcaa ctctttacac cgtagagctt atcaacacaa agttggcaac     1140

attattgata caatgattac agatgctttc ctcaaagcag atgactacat agagattaca     1200

ggtgctggag gaaaaaagta tcgcatttct acagcaattg acgacatgga agcctatact     1260

aagctgacag ataacatttt tctggagatt ttatactcta ctgatcccaa attgaaagac     1320

gcacgagaga ttttaaaaca aattgaatac cgtaatctat tcaagtatgt gggtgagacg     1380

cagccaacag gacaaataaa gattaaaagg gaggactatg aatctcttcc aaaagaggtt     1440

gccagtgcta aacccaaagt attgctagac gtgaaactga aggctgaaga ttttatagtg     1500

gatgttatca acatggatta tggaatgcaa gaaaagaatc caattgatca tgttagcttc     1560

tattgtaaga ctgcccccaa cagagcaatc aggattacta aaaaccaggt ttcacaactt     1620

ctgccagaga aatttgcaga gcagctgatt cgagtatatt gtaagaaggt ggacagaaag     1680

agtttgtatg ccgcaagaca atattttgtt cagtggtgtg cagacagaaa tttcaccaag     1740

ccgcaggatg gcgatgttat agccccactc ataacacctc aaaaaaagga atggaacgac     1800

agtacttcag tccaaaatcc aactcgcctc cgagaagcat ccaaaagcag agtccagctt     1860

tttaaagatg acccaatgtg a                                               1881


<210>  27
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gln Arg Ala Asp Ser Glu Gln Pro Ser Lys Arg Pro Arg Cys Asp 
1               5                   10                  15      


Asp Ser Pro Arg Thr Pro Ser Asn Thr Pro Ser Ala Glu Ala Asp Trp 
            20                  25                  30          


Ser Pro Gly Leu Glu Leu His Pro Asp Tyr Lys Thr Trp Gly Pro Glu 
        35                  40                  45              


Gln Val Cys Ser Phe Leu Arg Arg Gly Gly Phe Glu Glu Pro Val Leu 
    50                  55                  60                  


Leu Lys Asn Ile Arg Glu Asn Glu Ile Thr Gly Ala Leu Leu Pro Cys 
65                  70                  75                  80  


Leu Asp Glu Ser Arg Phe Glu Asn Leu Gly Val Ser Ser Leu Gly Glu 
                85                  90                  95      


Arg Lys Lys Leu Leu Ser Tyr Ile Gln Arg Leu Val Gln Ile His Val 
            100                 105                 110         


Asp Thr Met Lys Val Ile Asn Asp Pro Ile His Gly His Ile Glu Leu 
        115                 120                 125             


His Pro Leu Leu Val Arg Ile Ile Asp Thr Pro Gln Phe Gln Arg Leu 
    130                 135                 140                 


Arg Tyr Ile Lys Gln Leu Gly Gly Gly Tyr Tyr Val Phe Pro Gly Ala 
145                 150                 155                 160 


Ser His Asn Arg Phe Glu His Ser Leu Gly Val Gly Tyr Leu Ala Gly 
                165                 170                 175     


Cys Leu Val His Ala Leu Gly Glu Lys Gln Pro Glu Leu Gln Ile Ser 
            180                 185                 190         


Glu Arg Asp Val Leu Cys Val Gln Ile Ala Gly Leu Cys His Asp Leu 
        195                 200                 205             


Gly His Gly Pro Phe Ser His Met Phe Asp Gly Arg Phe Ile Pro Leu 
    210                 215                 220                 


Ala Arg Pro Glu Val Lys Trp Thr His Glu Gln Gly Ser Val Met Met 
225                 230                 235                 240 


Phe Glu His Leu Ile Asn Ser Asn Gly Ile Lys Pro Val Met Glu Gln 
                245                 250                 255     


Tyr Gly Leu Ile Pro Glu Glu Asp Ile Cys Phe Ile Lys Glu Gln Ile 
            260                 265                 270         


Val Gly Pro Leu Glu Ser Pro Val Glu Asp Ser Leu Trp Pro Tyr Lys 
        275                 280                 285             


Gly Arg Pro Glu Asn Lys Ser Phe Leu Tyr Glu Ile Val Ser Asn Lys 
    290                 295                 300                 


Arg Asn Gly Ile Asp Val Asp Lys Trp Asp Tyr Phe Ala Arg Asp Cys 
305                 310                 315                 320 


His His Leu Gly Ile Gln Asn Asn Phe Asp Tyr Lys Arg Phe Ile Lys 
                325                 330                 335     


Phe Ala Arg Val Cys Glu Val Asp Asn Glu Leu Arg Ile Cys Ala Arg 
            340                 345                 350         


Asp Lys Glu Val Gly Asn Leu Tyr Asp Met Phe His Thr Arg Asn Ser 
        355                 360                 365             


Leu His Arg Arg Ala Tyr Gln His Lys Val Gly Asn Ile Ile Asp Thr 
    370                 375                 380                 


Met Ile Thr Asp Ala Phe Leu Lys Ala Asp Asp Tyr Ile Glu Ile Thr 
385                 390                 395                 400 


Gly Ala Gly Gly Lys Lys Tyr Arg Ile Ser Thr Ala Ile Asp Asp Met 
                405                 410                 415     


Glu Ala Tyr Thr Lys Leu Thr Asp Asn Ile Phe Leu Glu Ile Leu Tyr 
            420                 425                 430         


Ser Thr Asp Pro Lys Leu Lys Asp Ala Arg Glu Ile Leu Lys Gln Ile 
        435                 440                 445             


Glu Tyr Arg Asn Leu Phe Lys Tyr Val Gly Glu Thr Gln Pro Thr Gly 
    450                 455                 460                 


Gln Ile Lys Ile Lys Arg Glu Asp Tyr Glu Ser Leu Pro Lys Glu Val 
465                 470                 475                 480 


Ala Ser Ala Lys Pro Lys Val Leu Leu Asp Val Lys Leu Lys Ala Glu 
                485                 490                 495     


Asp Phe Ile Val Asp Val Ile Asn Met Asp Tyr Gly Met Gln Glu Lys 
            500                 505                 510         


Asn Pro Ile Asp His Val Ser Phe Tyr Cys Lys Thr Ala Pro Asn Arg 
        515                 520                 525             


Ala Ile Arg Ile Thr Lys Asn Gln Val Ser Gln Leu Leu Pro Glu Lys 
    530                 535                 540                 


Phe Ala Glu Gln Leu Ile Arg Val Tyr Cys Lys Lys Val Asp Arg Lys 
545                 550                 555                 560 


Ser Leu Tyr Ala Ala Arg Gln Tyr Phe Val Gln Trp Cys Ala Asp Arg 
                565                 570                 575     


Asn Phe Thr Lys Pro Gln Asp Gly Asp Val Ile Ala Pro Leu Ile Thr 
            580                 585                 590         


Pro Gln Lys Lys Glu Trp Asn Asp Ser Thr Ser Val Gln Asn Pro Thr 
        595                 600                 605             


Arg Leu Arg Glu Ala Ser Lys Ser Arg Val Gln Leu Phe Lys Asp Asp 
    610                 615                 620                 


Pro Met 
625     


<210>  28
<211>  1776
<212>  DNA
<213>  Homo sapiens

<400>  28
atgcagcgag ccgattccga gcagccctcc aagcgtcccc gttgcgatga cagcccgaga       60

accccctcaa acaccccttc cgcagaggca gactggtccc cgggcctgga actccatccc      120

gactacaaga catggggtcc ggagcaggtg tgctccttcc tcaggcgcgg tggctttgaa      180

gagccggtgc tgctgaagaa catccgagaa aatgaaatca caggcgcatt actgccttgt      240

cttgatgagt ctcgttttga aaatcttgga gtaagttcct tgggggagag gaagaagctg      300

cttagttata tccagcgatt ggttcaaatc cacgttgata caatgaaggt aattaatgat      360

cctatccatg gccacattga gctccaccct ctcctcgtcc gaatcattga tacacctcaa      420

tttcaacgtc ttcgatacat caaacagctg ggaggtggtt actatgtttt tccaggagct      480

tcacacaatc gatttgagca tagtctaggg gtggggtatc tagcaggatg tctagttcac      540

gcactgggtg aaaaacaacc agagctgcag ataagtgaac gagatgttct ctgtgttcag      600

attgctggac tttgtcatga tctcggtcat gggccatttt ctcacatgtt tgatggacga      660

tttattccac ttgctcgccc ggaggtgaaa tggacgcatg aacaaggctc agttatgatg      720

tttgagcacc ttattaattc taatggaatt aagcctgtca tggaacaata tggtctcatc      780

cctgaagaag atatttgctt tataaaggaa caaattgtag gaccacttga atcacctgtc      840

gaagattcat tgtggccata taaagggcgt cctgaaaaca aaagcttcct ttatgagata      900

gtatctaata aaagaaatgg cattgatgtg gacaaatggg attattttgc cagggactgc      960

catcatcttg gaatccaaaa taattttgat tacaagcgct ttattaagtt tgcccgtgtc     1020

tgtgaagtag acaatgagtt gcgtatttgt gctagagata aggaagttgg aaatctgtat     1080

gacatgttcc acactcgcaa ctctttacac cgtagagctt atcaacacaa agttggcaac     1140

attattgata caatgattac agatgctttc ctcaaagcag atgactacat agagattaca     1200

ggtgctggag gaaaaaagta tcgcatttct acagcaattg acgacatgga agcctatact     1260

aagctgacag ataacatttt tctggagatt ttatactcta ctgatcccaa attgaaagac     1320

gcacgagaga ttttaaaaca aattgaatac cgtaatctat tcaagtatgt gggtgagacg     1380

cagccaacag gacaaataaa gattaaaagg gaggactatg aatctcttcc aaaagaggtt     1440

gccagtgcta aacccaaagt attgctagac gtgaaactga aggctgaaga ttttatagtg     1500

gatgtttcac aacttctgcc agagaaattt gcagagcagc tgattcgagt atattgtaag     1560

aaggtggaca gaaagagttt gtatgccgca agacaatatt ttgttcagtg gtgtgcagac     1620

agaaatttca ccaagccgca ggatggcgat gttatagccc cactcataac acctcaaaaa     1680

aaggaatgga acgacagtac ttcagtccaa aatccaactc gcctccgaga agcatccaaa     1740

agcagagtcc agctttttaa agatgaccca atgtga                               1776


<210>  29
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gln Arg Ala Asp Ser Glu Gln Pro Ser Lys Arg Pro Arg Cys Asp 
1               5                   10                  15      


Asp Ser Pro Arg Thr Pro Ser Asn Thr Pro Ser Ala Glu Ala Asp Trp 
            20                  25                  30          


Ser Pro Gly Leu Glu Leu His Pro Asp Tyr Lys Thr Trp Gly Pro Glu 
        35                  40                  45              


Gln Val Cys Ser Phe Leu Arg Arg Gly Gly Phe Glu Glu Pro Val Leu 
    50                  55                  60                  


Leu Lys Asn Ile Arg Glu Asn Glu Ile Thr Gly Ala Leu Leu Pro Cys 
65                  70                  75                  80  


Leu Asp Glu Ser Arg Phe Glu Asn Leu Gly Val Ser Ser Leu Gly Glu 
                85                  90                  95      


Arg Lys Lys Leu Leu Ser Tyr Ile Gln Arg Leu Val Gln Ile His Val 
            100                 105                 110         


Asp Thr Met Lys Val Ile Asn Asp Pro Ile His Gly His Ile Glu Leu 
        115                 120                 125             


His Pro Leu Leu Val Arg Ile Ile Asp Thr Pro Gln Phe Gln Arg Leu 
    130                 135                 140                 


Arg Tyr Ile Lys Gln Leu Gly Gly Gly Tyr Tyr Val Phe Pro Gly Ala 
145                 150                 155                 160 


Ser His Asn Arg Phe Glu His Ser Leu Gly Val Gly Tyr Leu Ala Gly 
                165                 170                 175     


Cys Leu Val His Ala Leu Gly Glu Lys Gln Pro Glu Leu Gln Ile Ser 
            180                 185                 190         


Glu Arg Asp Val Leu Cys Val Gln Ile Ala Gly Leu Cys His Asp Leu 
        195                 200                 205             


Gly His Gly Pro Phe Ser His Met Phe Asp Gly Arg Phe Ile Pro Leu 
    210                 215                 220                 


Ala Arg Pro Glu Val Lys Trp Thr His Glu Gln Gly Ser Val Met Met 
225                 230                 235                 240 


Phe Glu His Leu Ile Asn Ser Asn Gly Ile Lys Pro Val Met Glu Gln 
                245                 250                 255     


Tyr Gly Leu Ile Pro Glu Glu Asp Ile Cys Phe Ile Lys Glu Gln Ile 
            260                 265                 270         


Val Gly Pro Leu Glu Ser Pro Val Glu Asp Ser Leu Trp Pro Tyr Lys 
        275                 280                 285             


Gly Arg Pro Glu Asn Lys Ser Phe Leu Tyr Glu Ile Val Ser Asn Lys 
    290                 295                 300                 


Arg Asn Gly Ile Asp Val Asp Lys Trp Asp Tyr Phe Ala Arg Asp Cys 
305                 310                 315                 320 


His His Leu Gly Ile Gln Asn Asn Phe Asp Tyr Lys Arg Phe Ile Lys 
                325                 330                 335     


Phe Ala Arg Val Cys Glu Val Asp Asn Glu Leu Arg Ile Cys Ala Arg 
            340                 345                 350         


Asp Lys Glu Val Gly Asn Leu Tyr Asp Met Phe His Thr Arg Asn Ser 
        355                 360                 365             


Leu His Arg Arg Ala Tyr Gln His Lys Val Gly Asn Ile Ile Asp Thr 
    370                 375                 380                 


Met Ile Thr Asp Ala Phe Leu Lys Ala Asp Asp Tyr Ile Glu Ile Thr 
385                 390                 395                 400 


Gly Ala Gly Gly Lys Lys Tyr Arg Ile Ser Thr Ala Ile Asp Asp Met 
                405                 410                 415     


Glu Ala Tyr Thr Lys Leu Thr Asp Asn Ile Phe Leu Glu Ile Leu Tyr 
            420                 425                 430         


Ser Thr Asp Pro Lys Leu Lys Asp Ala Arg Glu Ile Leu Lys Gln Ile 
        435                 440                 445             


Glu Tyr Arg Asn Leu Phe Lys Tyr Val Gly Glu Thr Gln Pro Thr Gly 
    450                 455                 460                 


Gln Ile Lys Ile Lys Arg Glu Asp Tyr Glu Ser Leu Pro Lys Glu Val 
465                 470                 475                 480 


Ala Ser Ala Lys Pro Lys Val Leu Leu Asp Val Lys Leu Lys Ala Glu 
                485                 490                 495     


Asp Phe Ile Val Asp Val Ser Gln Leu Leu Pro Glu Lys Phe Ala Glu 
            500                 505                 510         


Gln Leu Ile Arg Val Tyr Cys Lys Lys Val Asp Arg Lys Ser Leu Tyr 
        515                 520                 525             


Ala Ala Arg Gln Tyr Phe Val Gln Trp Cys Ala Asp Arg Asn Phe Thr 
    530                 535                 540                 


Lys Pro Gln Asp Gly Asp Val Ile Ala Pro Leu Ile Thr Pro Gln Lys 
545                 550                 555                 560 


Lys Glu Trp Asn Asp Ser Thr Ser Val Gln Asn Pro Thr Arg Leu Arg 
                565                 570                 575     


Glu Ala Ser Lys Ser Arg Val Gln Leu Phe Lys Asp Asp Pro Met 
            580                 585                 590     


<210>  30
<211>  1770
<212>  DNA
<213>  Homo sapiens

<400>  30
atgcagcgag ccgattccga gcagccctcc aagcgtcccc gttgcgatga cagcccgaga       60

accccctcaa acaccccttc cgcagaggca gactggtccc cgggcctgga actccatccc      120

gactacaaga catggggtcc ggagcaggtg tgctccttcc tcaggcgcgg tggctttgaa      180

gagccggtgc tgctgaagaa catccgagaa aatgaaatca caggcgcatt actgccttgt      240

cttgatgagt ctcgttttga aaatcttgga gtaagttcct tgggggagag gaagaagctg      300

cttagttata tccagcgatt ggttcaaatc cacgttgata caatgaaggt aattaatgat      360

cctatccatg gccacattga gctccaccct ctcctcgtcc gaatcattga tacacctcaa      420

tttcaacgtc ttcgatacat caaacagctg ggaggtggtt actatgtttt tccaggagct      480

tcacacaatc gatttgagca tagtctaggg gtggggtatc tagcaggatg tctagttcac      540

gcactgggtg aaaaacaacc agagctgcag ataagtgaac gagatgttct ctgtgttcag      600

attgctggac tttgtcatga tctcggtcat gggccatttt ctcacatgtt tgatggacga      660

tttattccac ttgctcgccc ggaggtgaaa tggacgcatg aacaaggctc agttatgatg      720

tttgagcacc ttattaattc taatggaatt aagcctgtca tggaacaata tggtctcatc      780

cctgaagaag atatttgctt tataaaggaa caaattgtag gaccacttga atcacctgtc      840

gaagattcat tgtggccata taaagggcgt cctgaaaaca aaagcttcct ttatgagata      900

gtatctaata aaagaaatgg cattgatgtg gacaaatggg attattttgc cagggactgc      960

catcatcttg gaatccaaaa taattttgat tacaagcgct ttattaagtt tgcccgtgtc     1020

tgtgaagtag acaatgagtt gcgtatttgt gctagagata aggaagttgg aaatctgtat     1080

gacatgttcc acactcgcaa ctctttacac cgtagagctt atcaacacaa agttggcaac     1140

attattgata caatgattac agatgctttc ctcaaagcag atgactacat agagattaca     1200

ggtgctggag gaaaaaagta tcgcatttct acagcaattg acgacatgga agcctatact     1260

aagctgacag ataacatttt tctggagatt ttatactcta ctgatcccaa attgaaagac     1320

gcacgagaga ttttaaaaca aattgaatac cgtaatctat tcaagtatgt gggtgagacg     1380

cagccaacag gacaaataaa gattaaaagg gaggactatg aatctcttcc aaaagaggtt     1440

gccagtgcta aacccaaagt attgctagac gtgaaactga aggctgaaga ttttatagtg     1500

gatgttatca acatggatta tggaatgcaa gaaaagaatc caattgatca tgttagcttc     1560

tattgtaaga ctgcccccaa cagagcaatc aggattacta aaaaccaggt ttcacaactt     1620

ctgccagaga aatttgcaga gcagctgatt cgagtatatt gtaagaaggt ggacagaaag     1680

agtttgtatg ccgcaagaca atattttgtt cagtggtgtg cagacagaaa tttcaccaag     1740

ccgcagtctc ccaccagagc ctcccactga                                      1770


<210>  31
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Gln Arg Ala Asp Ser Glu Gln Pro Ser Lys Arg Pro Arg Cys Asp 
1               5                   10                  15      


Asp Ser Pro Arg Thr Pro Ser Asn Thr Pro Ser Ala Glu Ala Asp Trp 
            20                  25                  30          


Ser Pro Gly Leu Glu Leu His Pro Asp Tyr Lys Thr Trp Gly Pro Glu 
        35                  40                  45              


Gln Val Cys Ser Phe Leu Arg Arg Gly Gly Phe Glu Glu Pro Val Leu 
    50                  55                  60                  


Leu Lys Asn Ile Arg Glu Asn Glu Ile Thr Gly Ala Leu Leu Pro Cys 
65                  70                  75                  80  


Leu Asp Glu Ser Arg Phe Glu Asn Leu Gly Val Ser Ser Leu Gly Glu 
                85                  90                  95      


Arg Lys Lys Leu Leu Ser Tyr Ile Gln Arg Leu Val Gln Ile His Val 
            100                 105                 110         


Asp Thr Met Lys Val Ile Asn Asp Pro Ile His Gly His Ile Glu Leu 
        115                 120                 125             


His Pro Leu Leu Val Arg Ile Ile Asp Thr Pro Gln Phe Gln Arg Leu 
    130                 135                 140                 


Arg Tyr Ile Lys Gln Leu Gly Gly Gly Tyr Tyr Val Phe Pro Gly Ala 
145                 150                 155                 160 


Ser His Asn Arg Phe Glu His Ser Leu Gly Val Gly Tyr Leu Ala Gly 
                165                 170                 175     


Cys Leu Val His Ala Leu Gly Glu Lys Gln Pro Glu Leu Gln Ile Ser 
            180                 185                 190         


Glu Arg Asp Val Leu Cys Val Gln Ile Ala Gly Leu Cys His Asp Leu 
        195                 200                 205             


Gly His Gly Pro Phe Ser His Met Phe Asp Gly Arg Phe Ile Pro Leu 
    210                 215                 220                 


Ala Arg Pro Glu Val Lys Trp Thr His Glu Gln Gly Ser Val Met Met 
225                 230                 235                 240 


Phe Glu His Leu Ile Asn Ser Asn Gly Ile Lys Pro Val Met Glu Gln 
                245                 250                 255     


Tyr Gly Leu Ile Pro Glu Glu Asp Ile Cys Phe Ile Lys Glu Gln Ile 
            260                 265                 270         


Val Gly Pro Leu Glu Ser Pro Val Glu Asp Ser Leu Trp Pro Tyr Lys 
        275                 280                 285             


Gly Arg Pro Glu Asn Lys Ser Phe Leu Tyr Glu Ile Val Ser Asn Lys 
    290                 295                 300                 


Arg Asn Gly Ile Asp Val Asp Lys Trp Asp Tyr Phe Ala Arg Asp Cys 
305                 310                 315                 320 


His His Leu Gly Ile Gln Asn Asn Phe Asp Tyr Lys Arg Phe Ile Lys 
                325                 330                 335     


Phe Ala Arg Val Cys Glu Val Asp Asn Glu Leu Arg Ile Cys Ala Arg 
            340                 345                 350         


Asp Lys Glu Val Gly Asn Leu Tyr Asp Met Phe His Thr Arg Asn Ser 
        355                 360                 365             


Leu His Arg Arg Ala Tyr Gln His Lys Val Gly Asn Ile Ile Asp Thr 
    370                 375                 380                 


Met Ile Thr Asp Ala Phe Leu Lys Ala Asp Asp Tyr Ile Glu Ile Thr 
385                 390                 395                 400 


Gly Ala Gly Gly Lys Lys Tyr Arg Ile Ser Thr Ala Ile Asp Asp Met 
                405                 410                 415     


Glu Ala Tyr Thr Lys Leu Thr Asp Asn Ile Phe Leu Glu Ile Leu Tyr 
            420                 425                 430         


Ser Thr Asp Pro Lys Leu Lys Asp Ala Arg Glu Ile Leu Lys Gln Ile 
        435                 440                 445             


Glu Tyr Arg Asn Leu Phe Lys Tyr Val Gly Glu Thr Gln Pro Thr Gly 
    450                 455                 460                 


Gln Ile Lys Ile Lys Arg Glu Asp Tyr Glu Ser Leu Pro Lys Glu Val 
465                 470                 475                 480 


Ala Ser Ala Lys Pro Lys Val Leu Leu Asp Val Lys Leu Lys Ala Glu 
                485                 490                 495     


Asp Phe Ile Val Asp Val Ile Asn Met Asp Tyr Gly Met Gln Glu Lys 
            500                 505                 510         


Asn Pro Ile Asp His Val Ser Phe Tyr Cys Lys Thr Ala Pro Asn Arg 
        515                 520                 525             


Ala Ile Arg Ile Thr Lys Asn Gln Val Ser Gln Leu Leu Pro Glu Lys 
    530                 535                 540                 


Phe Ala Glu Gln Leu Ile Arg Val Tyr Cys Lys Lys Val Asp Arg Lys 
545                 550                 555                 560 


Ser Leu Tyr Ala Ala Arg Gln Tyr Phe Val Gln Trp Cys Ala Asp Arg 
                565                 570                 575     


Asn Phe Thr Lys Pro Gln Ser Pro Thr Arg Ala Ser His 
            580                 585                 


<210>  32
<211>  1083
<212>  DNA
<213>  Homo sapiens

<400>  32
atgatcccgc tgctgctggc agcgctgctg tgcgtccccg ccggggccct gacctgctac       60

ggggactccg ggcagcctgt agactggttc gtggtctaca agctgccagc tcttagaggg      120

tccggggagg cggcgcagag agggctgcag tacaagtatc tggacgagag ctccggaggc      180

tggcgggacg gcagggcact catcaacagc ccggaggggg ccgtgggccg aagcctgcag      240

ccgctgtacc ggagcaacac cagccagctc gccttcctgc tctacaatga ccaaccgcct      300

caacccagca aggctcagga ctcttccatg cgtgggcaca cgaagggtgt cctgctcctt      360

gaccacgatg ggggcttctg gctggtccac agtgtaccta acttccctcc accggcctcc      420

tctgctgcat acagctggcc tcatagcgcc tgtacctacg ggcagaccct gctctgtgtg      480

tcttttccct tcgctcagtt ctcgaagatg ggcaagcagc tgacctacac ctacccctgg      540

gtctataact accagctgga agggatcttt gcccaggaat tccccgactt ggagaatgtg      600

gtcaagggcc accacgttag ccaagaaccc tggaacagca gcatcacact cacatcccag      660

gccggggctg ttttccagag ctttgccaag ttcagcaaat ttggagatga cctgtactcc      720

ggctggttgg cagcagccct tggtaccaac ctgcaggtcc agttctggca caaaactgta      780

ggcatcctgc cctctaactg ctcggatatc tggcaggttc tgaatgtgaa ccagatagct      840

ttccctggac cagccggccc aagcttcaac agcacagagg accactccaa atggtgcgtg      900

tccccaaaag ggccctggac ctgcgtgggt gacatgaatc ggaaccaggg agaggagcaa      960

cggggtgggg gcacactgtg tgcccagctg ccagccctct ggaaagcctt ccagccgctg     1020

gtgaagaact accagccctg taatggcatg gccaggaagc ccagcagagc ttataagatc     1080

taa                                                                   1083


<210>  33
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ile Pro Leu Leu Leu Ala Ala Leu Leu Cys Val Pro Ala Gly Ala 
1               5                   10                  15      


Leu Thr Cys Tyr Gly Asp Ser Gly Gln Pro Val Asp Trp Phe Val Val 
            20                  25                  30          


Tyr Lys Leu Pro Ala Leu Arg Gly Ser Gly Glu Ala Ala Gln Arg Gly 
        35                  40                  45              


Leu Gln Tyr Lys Tyr Leu Asp Glu Ser Ser Gly Gly Trp Arg Asp Gly 
    50                  55                  60                  


Arg Ala Leu Ile Asn Ser Pro Glu Gly Ala Val Gly Arg Ser Leu Gln 
65                  70                  75                  80  


Pro Leu Tyr Arg Ser Asn Thr Ser Gln Leu Ala Phe Leu Leu Tyr Asn 
                85                  90                  95      


Asp Gln Pro Pro Gln Pro Ser Lys Ala Gln Asp Ser Ser Met Arg Gly 
            100                 105                 110         


His Thr Lys Gly Val Leu Leu Leu Asp His Asp Gly Gly Phe Trp Leu 
        115                 120                 125             


Val His Ser Val Pro Asn Phe Pro Pro Pro Ala Ser Ser Ala Ala Tyr 
    130                 135                 140                 


Ser Trp Pro His Ser Ala Cys Thr Tyr Gly Gln Thr Leu Leu Cys Val 
145                 150                 155                 160 


Ser Phe Pro Phe Ala Gln Phe Ser Lys Met Gly Lys Gln Leu Thr Tyr 
                165                 170                 175     


Thr Tyr Pro Trp Val Tyr Asn Tyr Gln Leu Glu Gly Ile Phe Ala Gln 
            180                 185                 190         


Glu Phe Pro Asp Leu Glu Asn Val Val Lys Gly His His Val Ser Gln 
        195                 200                 205             


Glu Pro Trp Asn Ser Ser Ile Thr Leu Thr Ser Gln Ala Gly Ala Val 
    210                 215                 220                 


Phe Gln Ser Phe Ala Lys Phe Ser Lys Phe Gly Asp Asp Leu Tyr Ser 
225                 230                 235                 240 


Gly Trp Leu Ala Ala Ala Leu Gly Thr Asn Leu Gln Val Gln Phe Trp 
                245                 250                 255     


His Lys Thr Val Gly Ile Leu Pro Ser Asn Cys Ser Asp Ile Trp Gln 
            260                 265                 270         


Val Leu Asn Val Asn Gln Ile Ala Phe Pro Gly Pro Ala Gly Pro Ser 
        275                 280                 285             


Phe Asn Ser Thr Glu Asp His Ser Lys Trp Cys Val Ser Pro Lys Gly 
    290                 295                 300                 


Pro Trp Thr Cys Val Gly Asp Met Asn Arg Asn Gln Gly Glu Glu Gln 
305                 310                 315                 320 


Arg Gly Gly Gly Thr Leu Cys Ala Gln Leu Pro Ala Leu Trp Lys Ala 
                325                 330                 335     


Phe Gln Pro Leu Val Lys Asn Tyr Gln Pro Cys Asn Gly Met Ala Arg 
            340                 345                 350         


Lys Pro Ser Arg Ala Tyr Lys Ile 
        355                 360 


<210>  34
<211>  1029
<212>  DNA
<213>  Homo sapiens

<400>  34
tgctacgggg actccgggca gcctgtagac tggttcgtgg tctacaagct gccagctctt       60

agagggtccg gggaggcggc gcagagaggg ctgcagtaca agtatctgga cgagagctcc      120

ggaggctggc gggacggcag ggcactcatc aacagcccgg agggggccgt gggccgaagc      180

ctgcagccgc tgtaccggag caacaccagc cagctcgcct tcctgctcta caatgaccaa      240

ccgcctcaac ccagcaaggc tcaggactct tccatgcgtg ggcacacgaa gggtgtcctg      300

ctccttgacc acgatggggg cttctggctg gtccacagtg tacctaactt ccctccaccg      360

gcctcctctg ctgcatacag ctggcctcat agcgcctgta cctacgggca gaccctgctc      420

tgtgtgtctt ttcccttcgc tcagttctcg aagatgggca agcagctgac ctacacctac      480

ccctgggtct ataactacca gctggaaggg atctttgccc aggaattccc cgacttggag      540

aatgtggtca agggccacca cgttagccaa gaaccctgga acagcagcat cacactcaca      600

tcccaggccg gggctgtttt ccagagcttt gccaagttca gcaaatttgg agatgacctg      660

tactccggct ggttggcagc agcccttggt accaacctgc aggtccagtt ctggcacaaa      720

actgtaggca tcctgccctc taactgctcg gatatctggc aggttctgaa tgtgaaccag      780

atagctttcc ctggaccagc cggcccaagc ttcaacagca cagaggacca ctccaaatgg      840

tgcgtgtccc caaaagggcc ctggacctgc gtgggtgaca tgaatcggaa ccagggagag      900

gagcaacggg gtgggggcac actgtgtgcc cagctgccag ccctctggaa agccttccag      960

ccgctggtga agaactacca gccctgtaat ggcatggcca ggaagcccag cagagcttat     1020

aagatctaa                                                             1029


<210>  35
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  35

Cys Tyr Gly Asp Ser Gly Gln Pro Val Asp Trp Phe Val Val Tyr Lys 
1               5                   10                  15      


Leu Pro Ala Leu Arg Gly Ser Gly Glu Ala Ala Gln Arg Gly Leu Gln 
            20                  25                  30          


Tyr Lys Tyr Leu Asp Glu Ser Ser Gly Gly Trp Arg Asp Gly Arg Ala 
        35                  40                  45              


Leu Ile Asn Ser Pro Glu Gly Ala Val Gly Arg Ser Leu Gln Pro Leu 
    50                  55                  60                  


Tyr Arg Ser Asn Thr Ser Gln Leu Ala Phe Leu Leu Tyr Asn Asp Gln 
65                  70                  75                  80  


Pro Pro Gln Pro Ser Lys Ala Gln Asp Ser Ser Met Arg Gly His Thr 
                85                  90                  95      


Lys Gly Val Leu Leu Leu Asp His Asp Gly Gly Phe Trp Leu Val His 
            100                 105                 110         


Ser Val Pro Asn Phe Pro Pro Pro Ala Ser Ser Ala Ala Tyr Ser Trp 
        115                 120                 125             


Pro His Ser Ala Cys Thr Tyr Gly Gln Thr Leu Leu Cys Val Ser Phe 
    130                 135                 140                 


Pro Phe Ala Gln Phe Ser Lys Met Gly Lys Gln Leu Thr Tyr Thr Tyr 
145                 150                 155                 160 


Pro Trp Val Tyr Asn Tyr Gln Leu Glu Gly Ile Phe Ala Gln Glu Phe 
                165                 170                 175     


Pro Asp Leu Glu Asn Val Val Lys Gly His His Val Ser Gln Glu Pro 
            180                 185                 190         


Trp Asn Ser Ser Ile Thr Leu Thr Ser Gln Ala Gly Ala Val Phe Gln 
        195                 200                 205             


Ser Phe Ala Lys Phe Ser Lys Phe Gly Asp Asp Leu Tyr Ser Gly Trp 
    210                 215                 220                 


Leu Ala Ala Ala Leu Gly Thr Asn Leu Gln Val Gln Phe Trp His Lys 
225                 230                 235                 240 


Thr Val Gly Ile Leu Pro Ser Asn Cys Ser Asp Ile Trp Gln Val Leu 
                245                 250                 255     


Asn Val Asn Gln Ile Ala Phe Pro Gly Pro Ala Gly Pro Ser Phe Asn 
            260                 265                 270         


Ser Thr Glu Asp His Ser Lys Trp Cys Val Ser Pro Lys Gly Pro Trp 
        275                 280                 285             


Thr Cys Val Gly Asp Met Asn Arg Asn Gln Gly Glu Glu Gln Arg Gly 
    290                 295                 300                 


Gly Gly Thr Leu Cys Ala Gln Leu Pro Ala Leu Trp Lys Ala Phe Gln 
305                 310                 315                 320 


Pro Leu Val Lys Asn Tyr Gln Pro Cys Asn Gly Met Ala Arg Lys Pro 
                325                 330                 335     


Ser Arg Ala Tyr Lys Ile 
            340         


<210>  36
<211>  4254
<212>  DNA
<213>  Homo sapiens

<400>  36
atggctgctg ttcctcaaaa taatctacag gagcaactag aacgtcactc agccagaaca       60

cttaataata aattaagtct ttcaaaacca aaattttcag gtttcacttt taaaaagaaa      120

acatcttcag ataacaatgt atctgtaact aatgtgtcag tagcaaaaac acctgtatta      180

agaaataaag atgttaatgt taccgaagac ttttccttca gtgaacctct acccaacacc      240

acaaatcagc aaagggtcaa ggacttcttt aaaaatgctc cagcaggaca ggaaacacag      300

agaggtggat caaaatcatt attgccagat ttcttgcaga ctccgaagga agttgtatgc      360

actacccaaa acacaccaac tgtaaagaaa tcccgggata ctgctctcaa gaaattagaa      420

tttagttctt caccagattc tttaagtacc atcaatgatt gggatgatat ggatgacttt      480

gatacttctg agacttcaaa atcatttgtt acaccacccc aaagtcactt tgtaagagta      540

agcactgctc agaaatcaaa aaagggtaag agaaactttt ttaaagcaca gctttataca      600

acaaacacag taaagactga tttgcctcca ccctcctctg aaagcgagca aatagatttg      660

actgaggaac agaaggatga ctcagaatgg ttaagcagcg atgtgatttg catcgatgat      720

ggccccattg ctgaagtgca tataaatgaa gatgctcagg aaagtgactc tctgaaaact      780

catttggaag atgaaagaga taatagcgaa aagaagaaga atttggaaga agctgaatta      840

cattcaactg agaaagttcc atgtattgaa tttgatgatg atgattatga tacggatttt      900

gttccacctt ctccagaaga aattatttct gcttcttctt cctcttcaaa atgccttagt      960

acgttaaagg accttgacac ctctgacaga aaagaggatg ttcttagcac atcaaaagat     1020

cttttgtcaa aacctgagaa aatgagtatg caggagctga atccagaaac cagcacagac     1080

tgtgacgcta gacagataag tttacagcag cagcttattc atgtgatgga gcacatctgt     1140

aaattaattg atactattcc tgatgataaa ctgaaacttt tggattgtgg gaacgaactg     1200

cttcagcagc ggaacataag aaggaaactt ctaacggaag tagattttaa taaaagtgat     1260

gccagtcttc ttggctcatt gtggagatac aggcctgatt cacttgatgg ccctatggag     1320

ggtgattcct gccctacagg gaattctatg aaggagttaa atttttcaca ccttccctca     1380

aattctgttt ctcctgggga ctgtttactg actaccaccc taggaaagac aggattctct     1440

gccaccagga agaatctttt tgaaaggcct ttattcaata cccatttaca gaagtccttt     1500

gtaagtagca actgggctga aacaccaaga ctaggaaaaa aaaatgaaag ctcttatttc     1560

ccaggaaatg ttctcacaag cactgctgtg aaagatcaga ataaacatac tgcttcaata     1620

aatgacttag aaagagaaac ccaaccttcc tatgatattg ataattttga catagatgac     1680

tttgatgatg atgatgactg ggaagacata atgcataatt tagcagccag caaatcttcc     1740

acagctgcct atcaacccat caaggaaggt cggccaatta aatcagtatc agaaagactt     1800

tcctcagcca agacagactg tcttccagtg tcatctactg ctcaaaatat aaacttctca     1860

gagtcaattc agaattatac tgacaagtca gcacaaaatt tagcatccag aaatctgaaa     1920

catgagcgtt tccaaagtct tagttttcct catacaaagg aaatgatgaa gatttttcat     1980

aaaaaatttg gcctgcataa ttttagaact aatcagctag aggcgatcaa tgctgcactg     2040

cttggtgaag actgttttat cctgatgccg actggaggtg gtaagagttt gtgttaccag     2100

ctccctgcct gtgtttctcc tggggtcact gttgtcattt ctcccttgag atcacttatc     2160

gtagatcaag tccaaaagct gacttccttg gatattccag ctacatatct gacaggtgat     2220

aagactgact cagaagctac aaatatttac ctccagttat caaaaaaaga cccaatcata     2280

aaacttctat atgtcactcc agaaaagatc tgtgcaagta acagactcat ttctactctg     2340

gagaatctct atgagaggaa gctcttggca cgttttgtta ttgatgaagc acattgtgtc     2400

agtcagtggg gacatgattt tcgtcaagat tacaaaagaa tgaatatgct tcgccagaag     2460

tttccttctg ttccggtgat ggctcttacg gccacagcta atcccagggt acagaaggac     2520

atcctgactc agctgaagat tctcagacct caggtgttta gcatgagctt taacagacat     2580

aatctgaaat actatgtatt accgaaaaag cctaaaaagg tggcatttga ttgcctagaa     2640

tggatcagaa agcaccaccc atatgattca gggataattt actgcctctc caggcgagaa     2700

tgtgacacca tggctgacac gttacagaga gatgggctcg ctgctcttgc ttaccatgct     2760

ggcctcagtg attctgccag agatgaagtg cagcagaagt ggattaatca ggatggctgt     2820

caggttatct gtgctacaat tgcatttgga atggggattg acaaaccgga cgtgcgattt     2880

gtgattcatg catctctccc taaatctgtg gagggttact accaagaatc tggcagagct     2940

ggaagagatg gggaaatatc tcactgcctg cttttctata cctatcatga tgtgaccaga     3000

ctgaaaagac ttataatgat ggaaaaagat ggaaaccatc atacaagaga aactcacttc     3060

aataatttgt atagcatggt acattactgt gaaaatataa cggaatgcag gagaatacag     3120

cttttggcct actttggtga aaatggattt aatcctgatt tttgtaagaa acacccagat     3180

gtttcttgtg ataattgctg taaaacaaag gattataaaa caagagatgt gactgacgat     3240

gtgaaaagta ttgtaagatt tgttcaagaa catagttcat cacaaggaat gagaaatata     3300

aaacatgtag gtccttctgg aagatttact atgaatatgc tggtcgacat tttcttgggg     3360

agtaagagtg caaaaatcca gtcaggtata tttggaaaag gatctgctta ttcacgacac     3420

aatgccgaaa gactttttaa aaagctgata cttgacaaga ttttggatga agacttatat     3480

atcaatgcca atgaccaggc gatcgcttat gtgatgctcg gaaataaagc ccaaactgta     3540

ctaaatggca atttaaaggt agactttatg gaaacagaaa attccagcag tgtgaaaaaa     3600

caaaaagcgt tagtagcaaa agtgtctcag agggaagaga tggttaaaaa atgtcttgga     3660

gaacttacag aagtctgcaa atctctgggg aaagtttttg gtgtccatta cttcaatatt     3720

tttaataccg tcactctcaa gaagcttgca gaatctttat cttctgatcc tgaggttttg     3780

cttcaaattg atggtgttac tgaagacaaa ctggaaaaat atggtgcgga agtgatttca     3840

gtattacaga aatactctga atggacatcg ccagctgaag acagttcccc agggataagc     3900

ctgtccagca gcagaggccc cggaagaagt gccgctgagg agctcgacga ggaaataccc     3960

gtatcttccc actactttgc aagtaaaacc agaaatgaaa ggaagaggaa aaagatgcca     4020

gcctcccaaa ggtctaagag gagaaaaact gcttccagtg gttccaaggc aaaggggggg     4080

tctgccacat gtagaaagat atcttccaaa acgaaatcct ccagcatcat tggatccagt     4140

tcagcctcac atacttctca agcgacatca ggagccaata gcaaattggg gattatggct     4200

ccaccgaagc ctataaatag accgtttctt aagccttcat atgcattctc ataa           4254


<210>  37
<211>  1417
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Thr Tyr His Asp Val Thr Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Thr  Arg Glu Thr His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Thr Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Thr Lys  Asp Tyr Lys Thr Arg  Asp Val Thr Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Thr  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Gly  Ser Lys Ser Ala Lys  Ile Gln Ser 
    1115                 1120                 1125             


Gly Ile  Phe Gly Lys Gly Ser  Ala Tyr Ser Arg His  Asn Ala Glu 
    1130                 1135                 1140             


Arg Leu  Phe Lys Lys Leu Ile  Leu Asp Lys Ile Leu  Asp Glu Asp 
    1145                 1150                 1155             


Leu Tyr  Ile Asn Ala Asn Asp  Gln Ala Ile Ala Tyr  Val Met Leu 
    1160                 1165                 1170             


Gly Asn  Lys Ala Gln Thr Val  Leu Asn Gly Asn Leu  Lys Val Asp 
    1175                 1180                 1185             


Phe Met  Glu Thr Glu Asn Ser  Ser Ser Val Lys Lys  Gln Lys Ala 
    1190                 1195                 1200             


Leu Val  Ala Lys Val Ser Gln  Arg Glu Glu Met Val  Lys Lys Cys 
    1205                 1210                 1215             


Leu Gly  Glu Leu Thr Glu Val  Cys Lys Ser Leu Gly  Lys Val Phe 
    1220                 1225                 1230             


Gly Val  His Tyr Phe Asn Ile  Phe Asn Thr Val Thr  Leu Lys Lys 
    1235                 1240                 1245             


Leu Ala  Glu Ser Leu Ser Ser  Asp Pro Glu Val Leu  Leu Gln Ile 
    1250                 1255                 1260             


Asp Gly  Val Thr Glu Asp Lys  Leu Glu Lys Tyr Gly  Ala Glu Val 
    1265                 1270                 1275             


Ile Ser  Val Leu Gln Lys Tyr  Ser Glu Trp Thr Ser  Pro Ala Glu 
    1280                 1285                 1290             


Asp Ser  Ser Pro Gly Ile Ser  Leu Ser Ser Ser Arg  Gly Pro Gly 
    1295                 1300                 1305             


Arg Ser  Ala Ala Glu Glu Leu  Asp Glu Glu Ile Pro  Val Ser Ser 
    1310                 1315                 1320             


His Tyr  Phe Ala Ser Lys Thr  Arg Asn Glu Arg Lys  Arg Lys Lys 
    1325                 1330                 1335             


Met Pro  Ala Ser Gln Arg Ser  Lys Arg Arg Lys Thr  Ala Ser Ser 
    1340                 1345                 1350             


Gly Ser  Lys Ala Lys Gly Gly  Ser Ala Thr Cys Arg  Lys Ile Ser 
    1355                 1360                 1365             


Ser Lys  Thr Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
    1370                 1375                 1380             


His Thr  Ser Gln Ala Thr Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1385                 1390                 1395             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1400                 1405                 1410             


Tyr Ala  Phe Ser 
    1415         


<210>  38
<211>  3861
<212>  DNA
<213>  Homo sapiens

<400>  38
atggctgctg ttcctcaaaa taatctacag gagcaactag aacgtcactc agccagaaca       60

cttaataata aattaagtct ttcaaaacca aaattttcag gtttcacttt taaaaagaaa      120

acatcttcag ataacaatgt atctgtaact aatgtgtcag tagcaaaaac acctgtatta      180

agaaataaag atgttaatgt taccgaagac ttttccttca gtgaacctct acccaacacc      240

acaaatcagc aaagggtcaa ggacttcttt aaaaatgctc cagcaggaca ggaaacacag      300

agaggtggat caaaatcatt attgccagat ttcttgcaga ctccgaagga agttgtatgc      360

actacccaaa acacaccaac tgtaaagaaa tcccgggata ctgctctcaa gaaattagaa      420

tttagttctt caccagattc tttaagtacc atcaatgatt gggatgatat ggatgacttt      480

gatacttctg agacttcaaa atcatttgtt acaccacccc aaagtcactt tgtaagagta      540

agcactgctc agaaatcaaa aaagggtaag agaaactttt ttaaagcaca gctttataca      600

acaaacacag taaagactga tttgcctcca ccctcctctg aaagcgagca aatagatttg      660

actgaggaac agaaggatga ctcagaatgg ttaagcagcg atgtgatttg catcgatgat      720

ggccccattg ctgaagtgca tataaatgaa gatgctcagg aaagtgactc tctgaaaact      780

catttggaag atgaaagaga taatagcgaa aagaagaaga atttggaaga agctgaatta      840

cattcaactg agaaagttcc atgtattgaa tttgatgatg atgattatga tacggatttt      900

gttccacctt ctccagaaga aattatttct gcttcttctt cctcttcaaa atgccttagt      960

acgttaaagg accttgacac ctctgacaga aaagaggatg ttcttagcac atcaaaagat     1020

cttttgtcaa aacctgagaa aatgagtatg caggagctga atccagaaac cagcacagac     1080

tgtgacgcta gacagataag tttacagcag cagcttattc atgtgatgga gcacatctgt     1140

aaattaattg atactattcc tgatgataaa ctgaaacttt tggattgtgg gaacgaactg     1200

cttcagcagc ggaacataag aaggaaactt ctaacggaag tagattttaa taaaagtgat     1260

gccagtcttc ttggctcatt gtggagatac aggcctgatt cacttgatgg ccctatggag     1320

ggtgattcct gccctacagg gaattctatg aaggagttaa atttttcaca ccttccctca     1380

aattctgttt ctcctgggga ctgtttactg actaccaccc taggaaagac aggattctct     1440

gccaccagga agaatctttt tgaaaggcct ttattcaata cccatttaca gaagtccttt     1500

gtaagtagca actgggctga aacaccaaga ctaggaaaaa aaaatgaaag ctcttatttc     1560

ccaggaaatg ttctcacaag cactgctgtg aaagatcaga ataaacatac tgcttcaata     1620

aatgacttag aaagagaaac ccaaccttcc tatgatattg ataattttga catagatgac     1680

tttgatgatg atgatgactg ggaagacata atgcataatt tagcagccag caaatcttcc     1740

acagctgcct atcaacccat caaggaaggt cggccaatta aatcagtatc agaaagactt     1800

tcctcagcca agacagactg tcttccagtg tcatctactg ctcaaaatat aaacttctca     1860

gagtcaattc agaattatac tgacaagtca gcacaaaatt tagcatccag aaatctgaaa     1920

catgagcgtt tccaaagtct tagttttcct catacaaagg aaatgatgaa gatttttcat     1980

aaaaaatttg gcctgcataa ttttagaact aatcagctag aggcgatcaa tgctgcactg     2040

cttggtgaag actgttttat cctgatgccg actggaggtg gtaagagttt gtgttaccag     2100

ctccctgcct gtgtttctcc tggggtcact gttgtcattt ctcccttgag atcacttatc     2160

gtagatcaag tccaaaagct gacttccttg gatattccag ctacatatct gacaggtgat     2220

aagactgact cagaagctac aaatatttac ctccagttat caaaaaaaga cccaatcata     2280

aaacttctat atgtcactcc agaaaagatc tgtgcaagta acagactcat ttctactctg     2340

gagaatctct atgagaggaa gctcttggca cgttttgtta ttgatgaagc acattgtgtc     2400

agtcagtggg gacatgattt tcgtcaagat tacaaaagaa tgaatatgct tcgccagaag     2460

tttccttctg ttccggtgat ggctcttacg gccacagcta atcccagggt acagaaggac     2520

atcctgactc agctgaagat tctcagacct caggtgttta gcatgagctt taacagacat     2580

aatctgaaat actatgtatt accgaaaaag cctaaaaagg tggcatttga ttgcctagaa     2640

tggatcagaa agcaccaccc atatgattca gggataattt actgcctctc caggcgagaa     2700

tgtgacacca tggctgacac gttacagaga gatgggctcg ctgctcttgc ttaccatgct     2760

ggcctcagtg attctgccag agatgaagtg cagcagaagt ggattaatca ggatggctgt     2820

caggttatct gtgctacaat tgcatttgga atggggattg acaaaccgga cgtgcgattt     2880

gtgattcatg catctctccc taaatctgtg gagggttact accaagaatc tggcagagct     2940

ggaagagatg gggaaatatc tcactgcctg cttttctata cctatcatga tgtgaccaga     3000

ctgaaaagac ttataatgat ggaaaaagat ggaaaccatc atacaagaga aactcacttc     3060

aataatttgt atagcatggt acattactgt gaaaatataa cggaatgcag gagaatacag     3120

cttttggcct actttggtga aaatggattt aatcctgatt tttgtaagaa acacccagat     3180

gtttcttgtg ataattgctg taaaacaaag gattataaaa caagagatgt gactgacgat     3240

gtgaaaagta ttgtaagatt tgttcaagaa catagttcat cacaaggaat gagaaatata     3300

aaacatgtag gtccttctgg aagatttact atgaatatgc tggtcgacat tttcttggaa     3360

tctttatctt ctgatcctga ggttttgctt caaattgatg gtgttactga agacaaactg     3420

gaaaaatatg gtgcggaagt gatttcagta ttacagaaat actctgaatg gacatcgcca     3480

gctgaagaca gttccccagg gataagcctg tccagcagca gaggccccgg aagaagtgcc     3540

gctgaggagc tcgacgagga aatacccgta tcttcccact actttgcaag taaaaccaga     3600

aatgaaagga agaggaaaaa gatgccagcc tcccaaaggt ctaagaggag aaaaactgct     3660

tccagtggtt ccaaggcaaa gggggggtct gccacatgta gaaagatatc ttccaaaacg     3720

aaatcctcca gcatcattgg atccagttca gcctcacata cttctcaagc gacatcagga     3780

gccaatagca aattggggat tatggctcca ccgaagccta taaatagacc gtttcttaag     3840

ccttcatatg cattctcata a                                               3861


<210>  39
<211>  1286
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Thr Tyr His Asp Val Thr Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Thr  Arg Glu Thr His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Thr Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Thr Lys  Asp Tyr Lys Thr Arg  Asp Val Thr Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Thr  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Glu  Ser Leu Ser Ser Asp  Pro Glu Val 
    1115                 1120                 1125             


Leu Leu  Gln Ile Asp Gly Val  Thr Glu Asp Lys Leu  Glu Lys Tyr 
    1130                 1135                 1140             


Gly Ala  Glu Val Ile Ser Val  Leu Gln Lys Tyr Ser  Glu Trp Thr 
    1145                 1150                 1155             


Ser Pro  Ala Glu Asp Ser Ser  Pro Gly Ile Ser Leu  Ser Ser Ser 
    1160                 1165                 1170             


Arg Gly  Pro Gly Arg Ser Ala  Ala Glu Glu Leu Asp  Glu Glu Ile 
    1175                 1180                 1185             


Pro Val  Ser Ser His Tyr Phe  Ala Ser Lys Thr Arg  Asn Glu Arg 
    1190                 1195                 1200             


Lys Arg  Lys Lys Met Pro Ala  Ser Gln Arg Ser Lys  Arg Arg Lys 
    1205                 1210                 1215             


Thr Ala  Ser Ser Gly Ser Lys  Ala Lys Gly Gly Ser  Ala Thr Cys 
    1220                 1225                 1230             


Arg Lys  Ile Ser Ser Lys Thr  Lys Ser Ser Ser Ile  Ile Gly Ser 
    1235                 1240                 1245             


Ser Ser  Ala Ser His Thr Ser  Gln Ala Thr Ser Gly  Ala Asn Ser 
    1250                 1255                 1260             


Lys Leu  Gly Ile Met Ala Pro  Pro Lys Pro Ile Asn  Arg Pro Phe 
    1265                 1270                 1275             


Leu Lys  Pro Ser Tyr Ala Phe  Ser 
    1280                 1285     


<210>  40
<211>  3129
<212>  DNA
<213>  Homo sapiens

<400>  40
atggagcaca tctgtaaatt aattgatact attcctgatg ataaactgaa acttttggat       60

tgtgggaacg aactgcttca gcagcggaac ataagaagga aacttctaac ggaagtagat      120

tttaataaaa gtgatgccag tcttcttggc tcattgtgga gatacaggcc tgattcactt      180

gatggcccta tggagggtga ttcctgccct acagggaatt ctatgaagga gttaaatttt      240

tcacaccttc cctcaaattc tgtttctcct ggggactgtt tactgactac caccctagga      300

aagacaggat tctctgccac caggaagaat ctttttgaaa ggcctttatt caatacccat      360

ttacagaagt cctttgtaag tagcaactgg gctgaaacac caagactagg aaaaaaaaat      420

gaaagctctt atttcccagg aaatgttctc acaagcactg ctgtgaaaga tcagaataaa      480

catactgctt caataaatga cttagaaaga gaaacccaac cttcctatga tattgataat      540

tttgacatag atgactttga tgatgatgat gactgggaag acataatgca taatttagca      600

gccagcaaat cttccacagc tgcctatcaa cccatcaagg aaggtcggcc aattaaatca      660

gtatcagaaa gactttcctc agccaagaca gactgtcttc cagtgtcatc tactgctcaa      720

aatataaact tctcagagtc aattcagaat tatactgaca agtcagcaca aaatttagca      780

tccagaaatc tgaaacatga gcgtttccaa agtcttagtt ttcctcatac aaaggaaatg      840

atgaagattt ttcataaaaa atttggcctg cataatttta gaactaatca gctagaggcg      900

atcaatgctg cactgcttgg tgaagactgt tttatcctga tgccgactgg aggtggtaag      960

agtttgtgtt accagctccc tgcctgtgtt tctcctgggg tcactgttgt catttctccc     1020

ttgagatcac ttatcgtaga tcaagtccaa aagctgactt ccttggatat tccagctaca     1080

tatctgacag gtgataagac tgactcagaa gctacaaata tttacctcca gttatcaaaa     1140

aaagacccaa tcataaaact tctatatgtc actccagaaa agatctgtgc aagtaacaga     1200

ctcatttcta ctctggagaa tctctatgag aggaagctct tggcacgttt tgttattgat     1260

gaagcacatt gtgtcagtca gtggggacat gattttcgtc aagattacaa aagaatgaat     1320

atgcttcgcc agaagtttcc ttctgttccg gtgatggctc ttacggccac agctaatccc     1380

agggtacaga aggacatcct gactcagctg aagattctca gacctcaggt gtttagcatg     1440

agctttaaca gacataatct gaaatactat gtattaccga aaaagcctaa aaaggtggca     1500

tttgattgcc tagaatggat cagaaagcac cacccatatg attcagggat aatttactgc     1560

ctctccaggc gagaatgtga caccatggct gacacgttac agagagatgg gctcgctgct     1620

cttgcttacc atgctggcct cagtgattct gccagagatg aagtgcagca gaagtggatt     1680

aatcaggatg gctgtcaggt tatctgtgct acaattgcat ttggaatggg gattgacaaa     1740

ccggacgtgc gatttgtgat tcatgcatct ctccctaaat ctgtggaggg ttactaccaa     1800

gaatctggca gagctggaag agatggggaa atatctcact gcctgctttt ctatacctat     1860

catgatgtga ccagactgaa aagacttata atgatggaaa aagatggaaa ccatcataca     1920

agagaaactc acttcaataa tttgtatagc atggtacatt actgtgaaaa tataacggaa     1980

tgcaggagaa tacagctttt ggcctacttt ggtgaaaatg gatttaatcc tgatttttgt     2040

aagaaacacc cagatgtttc ttgtgataat tgctgtaaaa caaaggatta taaaacaaga     2100

gatgtgactg acgatgtgaa aagtattgta agatttgttc aagaacatag ttcatcacaa     2160

ggaatgagaa atataaaaca tgtaggtcct tctggaagat ttactatgaa tatgctggtc     2220

gacattttct tggggagtaa gagtgcaaaa atccagtcag gtatatttgg aaaaggatct     2280

gcttattcac gacacaatgc cgaaagactt tttaaaaagc tgatacttga caagattttg     2340

gatgaagact tatatatcaa tgccaatgac caggcgatcg cttatgtgat gctcggaaat     2400

aaagcccaaa ctgtactaaa tggcaattta aaggtagact ttatggaaac agaaaattcc     2460

agcagtgtga aaaaacaaaa agcgttagta gcaaaagtgt ctcagaggga agagatggtt     2520

aaaaaatgtc ttggagaact tacagaagtc tgcaaatctc tggggaaagt ttttggtgtc     2580

cattacttca atatttttaa taccgtcact ctcaagaagc ttgcagaatc tttatcttct     2640

gatcctgagg ttttgcttca aattgatggt gttactgaag acaaactgga aaaatatggt     2700

gcggaagtga tttcagtatt acagaaatac tctgaatgga catcgccagc tgaagacagt     2760

tccccaggga taagcctgtc cagcagcaga ggccccggaa gaagtgccgc tgaggagctc     2820

gacgaggaaa tacccgtatc ttcccactac tttgcaagta aaaccagaaa tgaaaggaag     2880

aggaaaaaga tgccagcctc ccaaaggtct aagaggagaa aaactgcttc cagtggttcc     2940

aaggcaaagg gggggtctgc cacatgtaga aagatatctt ccaaaacgaa atcctccagc     3000

atcattggat ccagttcagc ctcacatact tctcaagcga catcaggagc caatagcaaa     3060

ttggggatta tggctccacc gaagcctata aatagaccgt ttcttaagcc ttcatatgca     3120

ttctcataa                                                             3129


<210>  41
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu His Ile Cys Lys Leu Ile Asp Thr Ile Pro Asp Asp Lys Leu 
1               5                   10                  15      


Lys Leu Leu Asp Cys Gly Asn Glu Leu Leu Gln Gln Arg Asn Ile Arg 
            20                  25                  30          


Arg Lys Leu Leu Thr Glu Val Asp Phe Asn Lys Ser Asp Ala Ser Leu 
        35                  40                  45              


Leu Gly Ser Leu Trp Arg Tyr Arg Pro Asp Ser Leu Asp Gly Pro Met 
    50                  55                  60                  


Glu Gly Asp Ser Cys Pro Thr Gly Asn Ser Met Lys Glu Leu Asn Phe 
65                  70                  75                  80  


Ser His Leu Pro Ser Asn Ser Val Ser Pro Gly Asp Cys Leu Leu Thr 
                85                  90                  95      


Thr Thr Leu Gly Lys Thr Gly Phe Ser Ala Thr Arg Lys Asn Leu Phe 
            100                 105                 110         


Glu Arg Pro Leu Phe Asn Thr His Leu Gln Lys Ser Phe Val Ser Ser 
        115                 120                 125             


Asn Trp Ala Glu Thr Pro Arg Leu Gly Lys Lys Asn Glu Ser Ser Tyr 
    130                 135                 140                 


Phe Pro Gly Asn Val Leu Thr Ser Thr Ala Val Lys Asp Gln Asn Lys 
145                 150                 155                 160 


His Thr Ala Ser Ile Asn Asp Leu Glu Arg Glu Thr Gln Pro Ser Tyr 
                165                 170                 175     


Asp Ile Asp Asn Phe Asp Ile Asp Asp Phe Asp Asp Asp Asp Asp Trp 
            180                 185                 190         


Glu Asp Ile Met His Asn Leu Ala Ala Ser Lys Ser Ser Thr Ala Ala 
        195                 200                 205             


Tyr Gln Pro Ile Lys Glu Gly Arg Pro Ile Lys Ser Val Ser Glu Arg 
    210                 215                 220                 


Leu Ser Ser Ala Lys Thr Asp Cys Leu Pro Val Ser Ser Thr Ala Gln 
225                 230                 235                 240 


Asn Ile Asn Phe Ser Glu Ser Ile Gln Asn Tyr Thr Asp Lys Ser Ala 
                245                 250                 255     


Gln Asn Leu Ala Ser Arg Asn Leu Lys His Glu Arg Phe Gln Ser Leu 
            260                 265                 270         


Ser Phe Pro His Thr Lys Glu Met Met Lys Ile Phe His Lys Lys Phe 
        275                 280                 285             


Gly Leu His Asn Phe Arg Thr Asn Gln Leu Glu Ala Ile Asn Ala Ala 
    290                 295                 300                 


Leu Leu Gly Glu Asp Cys Phe Ile Leu Met Pro Thr Gly Gly Gly Lys 
305                 310                 315                 320 


Ser Leu Cys Tyr Gln Leu Pro Ala Cys Val Ser Pro Gly Val Thr Val 
                325                 330                 335     


Val Ile Ser Pro Leu Arg Ser Leu Ile Val Asp Gln Val Gln Lys Leu 
            340                 345                 350         


Thr Ser Leu Asp Ile Pro Ala Thr Tyr Leu Thr Gly Asp Lys Thr Asp 
        355                 360                 365             


Ser Glu Ala Thr Asn Ile Tyr Leu Gln Leu Ser Lys Lys Asp Pro Ile 
    370                 375                 380                 


Ile Lys Leu Leu Tyr Val Thr Pro Glu Lys Ile Cys Ala Ser Asn Arg 
385                 390                 395                 400 


Leu Ile Ser Thr Leu Glu Asn Leu Tyr Glu Arg Lys Leu Leu Ala Arg 
                405                 410                 415     


Phe Val Ile Asp Glu Ala His Cys Val Ser Gln Trp Gly His Asp Phe 
            420                 425                 430         


Arg Gln Asp Tyr Lys Arg Met Asn Met Leu Arg Gln Lys Phe Pro Ser 
        435                 440                 445             


Val Pro Val Met Ala Leu Thr Ala Thr Ala Asn Pro Arg Val Gln Lys 
    450                 455                 460                 


Asp Ile Leu Thr Gln Leu Lys Ile Leu Arg Pro Gln Val Phe Ser Met 
465                 470                 475                 480 


Ser Phe Asn Arg His Asn Leu Lys Tyr Tyr Val Leu Pro Lys Lys Pro 
                485                 490                 495     


Lys Lys Val Ala Phe Asp Cys Leu Glu Trp Ile Arg Lys His His Pro 
            500                 505                 510         


Tyr Asp Ser Gly Ile Ile Tyr Cys Leu Ser Arg Arg Glu Cys Asp Thr 
        515                 520                 525             


Met Ala Asp Thr Leu Gln Arg Asp Gly Leu Ala Ala Leu Ala Tyr His 
    530                 535                 540                 


Ala Gly Leu Ser Asp Ser Ala Arg Asp Glu Val Gln Gln Lys Trp Ile 
545                 550                 555                 560 


Asn Gln Asp Gly Cys Gln Val Ile Cys Ala Thr Ile Ala Phe Gly Met 
                565                 570                 575     


Gly Ile Asp Lys Pro Asp Val Arg Phe Val Ile His Ala Ser Leu Pro 
            580                 585                 590         


Lys Ser Val Glu Gly Tyr Tyr Gln Glu Ser Gly Arg Ala Gly Arg Asp 
        595                 600                 605             


Gly Glu Ile Ser His Cys Leu Leu Phe Tyr Thr Tyr His Asp Val Thr 
    610                 615                 620                 


Arg Leu Lys Arg Leu Ile Met Met Glu Lys Asp Gly Asn His His Thr 
625                 630                 635                 640 


Arg Glu Thr His Phe Asn Asn Leu Tyr Ser Met Val His Tyr Cys Glu 
                645                 650                 655     


Asn Ile Thr Glu Cys Arg Arg Ile Gln Leu Leu Ala Tyr Phe Gly Glu 
            660                 665                 670         


Asn Gly Phe Asn Pro Asp Phe Cys Lys Lys His Pro Asp Val Ser Cys 
        675                 680                 685             


Asp Asn Cys Cys Lys Thr Lys Asp Tyr Lys Thr Arg Asp Val Thr Asp 
    690                 695                 700                 


Asp Val Lys Ser Ile Val Arg Phe Val Gln Glu His Ser Ser Ser Gln 
705                 710                 715                 720 


Gly Met Arg Asn Ile Lys His Val Gly Pro Ser Gly Arg Phe Thr Met 
                725                 730                 735     


Asn Met Leu Val Asp Ile Phe Leu Gly Ser Lys Ser Ala Lys Ile Gln 
            740                 745                 750         


Ser Gly Ile Phe Gly Lys Gly Ser Ala Tyr Ser Arg His Asn Ala Glu 
        755                 760                 765             


Arg Leu Phe Lys Lys Leu Ile Leu Asp Lys Ile Leu Asp Glu Asp Leu 
    770                 775                 780                 


Tyr Ile Asn Ala Asn Asp Gln Ala Ile Ala Tyr Val Met Leu Gly Asn 
785                 790                 795                 800 


Lys Ala Gln Thr Val Leu Asn Gly Asn Leu Lys Val Asp Phe Met Glu 
                805                 810                 815     


Thr Glu Asn Ser Ser Ser Val Lys Lys Gln Lys Ala Leu Val Ala Lys 
            820                 825                 830         


Val Ser Gln Arg Glu Glu Met Val Lys Lys Cys Leu Gly Glu Leu Thr 
        835                 840                 845             


Glu Val Cys Lys Ser Leu Gly Lys Val Phe Gly Val His Tyr Phe Asn 
    850                 855                 860                 


Ile Phe Asn Thr Val Thr Leu Lys Lys Leu Ala Glu Ser Leu Ser Ser 
865                 870                 875                 880 


Asp Pro Glu Val Leu Leu Gln Ile Asp Gly Val Thr Glu Asp Lys Leu 
                885                 890                 895     


Glu Lys Tyr Gly Ala Glu Val Ile Ser Val Leu Gln Lys Tyr Ser Glu 
            900                 905                 910         


Trp Thr Ser Pro Ala Glu Asp Ser Ser Pro Gly Ile Ser Leu Ser Ser 
        915                 920                 925             


Ser Arg Gly Pro Gly Arg Ser Ala Ala Glu Glu Leu Asp Glu Glu Ile 
    930                 935                 940                 


Pro Val Ser Ser His Tyr Phe Ala Ser Lys Thr Arg Asn Glu Arg Lys 
945                 950                 955                 960 


Arg Lys Lys Met Pro Ala Ser Gln Arg Ser Lys Arg Arg Lys Thr Ala 
                965                 970                 975     


Ser Ser Gly Ser Lys Ala Lys Gly Gly Ser Ala Thr Cys Arg Lys Ile 
            980                 985                 990         


Ser Ser Lys Thr Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
        995                 1000                 1005             


His Thr  Ser Gln Ala Thr Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1010                 1015                 1020             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1025                 1030                 1035             


Tyr Ala  Phe Ser 
    1040         


<210>  42
<211>  3045
<212>  DNA
<213>  Homo sapiens

<400>  42
atggcggagt cttcggataa gctctatcga gtcgagtacg ccaagagcgg gcgcgcctct       60

tgcaagaaat gcagcgagag catccccaag gactcgctcc ggatggccat catggtgcag      120

tcgcccatgt ttgatggaaa agtcccacac tggtaccact tctcctgctt ctggaaggtg      180

ggccactcca tccggcaccc tgacgttgag gtggatgggt tctctgagct tcggtgggat      240

gaccagcaga aagtcaagaa gacagcggaa gctggaggag tgacaggcaa aggccaggat      300

ggaattggta gcaaggcaga gaagactctg ggtgactttg cagcagagta tgccaagtcc      360

aacagaagta cgtgcaaggg gtgtatggag aagatagaaa agggccaggt gcgcctgtcc      420

aagaagatgg tggacccgga gaagccacag ctaggcatga ttgaccgctg gtaccatcca      480

ggctgctttg tcaagaacag ggaggagctg ggtttccggc ccgagtacag tgcgagtcag      540

ctcaagggct tcagcctcct tgctacagag gataaagaag ccctgaagaa gcagctccca      600

ggagtcaaga gtgaaggaaa gagaaaaggc gatgaggtgg atggagtgga tgaagtggcg      660

aagaagaaat ctaaaaaaga aaaagacaag gatagtaagc ttgaaaaagc cctaaaggct      720

cagaacgacc tgatctggaa catcaaggac gagctaaaga aagtgtgttc aactaatgac      780

ctgaaggagc tactcatctt caacaagcag caagtgcctt ctggggagtc ggcgatcttg      840

gaccgagtag ctgatggcat ggtgttcggt gccctccttc cctgcgagga atgctcgggt      900

cagctggtct tcaagagcga tgcctattac tgcactgggg acgtcactgc ctggaccaag      960

tgtatggtca agacacagac acccaaccgg aaggagtggg taaccccaaa ggaattccga     1020

gaaatctctt acctcaagaa attgaaggtt aaaaaacagg accgtatatt ccccccagaa     1080

accagcgcct ccgtggcggc cacgcctccg ccctccacag cctcggctcc tgctgctgtg     1140

aactcctctg cttcagcaga taagccatta tccaacatga agatcctgac tctcgggaag     1200

ctgtcccgga acaaggatga agtgaaggcc atgattgaga aactcggggg gaagttgacg     1260

gggacggcca acaaggcttc cctgtgcatc agcaccaaaa aggaggtgga aaagatgaat     1320

aagaagatgg aggaagtaaa ggaagccaac atccgagttg tgtctgagga cttcctccag     1380

gacgtctccg cctccaccaa gagccttcag gagttgttct tagcgcacat cttgtcccct     1440

tggggggcag aggtgaaggc agagcctgtt gaagttgtgg ccccaagagg gaagtcaggg     1500

gctgcgctct ccaaaaaaag caagggccag gtcaaggagg aaggtatcaa caaatctgaa     1560

aagagaatga aattaactct taaaggagga gcagctgtgg atcctgattc tggactggaa     1620

cactctgcgc atgtcctgga gaaaggtggg aaggtcttca gtgccaccct tggcctggtg     1680

gacatcgtta aaggaaccaa ctcctactac aagctgcagc ttctggagga cgacaaggaa     1740

aacaggtatt ggatattcag gtcctggggc cgtgtgggta cggtgatcgg tagcaacaaa     1800

ctggaacaga tgccgtccaa ggaggatgcc attgagcact tcatgaaatt atatgaagaa     1860

aaaaccggga acgcttggca ctccaaaaat ttcacgaagt atcccaaaaa gttctacccc     1920

ctggagattg actatggcca ggatgaagag gcagtgaaga agctgacagt aaatcctggc     1980

accaagtcca agctccccaa gccagttcag gacctcatca agatgatctt tgatgtggaa     2040

agtatgaaga aagccatggt ggagtatgag atcgaccttc agaagatgcc cttggggaag     2100

ctgagcaaaa ggcagatcca ggccgcatac tccatcctca gtgaggtcca gcaggcggtg     2160

tctcagggca gcagcgactc tcagatcctg gatctctcaa atcgctttta caccctgatc     2220

ccccacgact ttgggatgaa gaagcctccg ctcctgaaca atgcagacag tgtgcaggcc     2280

aaggtggaaa tgcttgacaa cctgctggac atcgaggtgg cctacagtct gctcagggga     2340

gggtctgatg atagcagcaa ggatcccatc gatgtcaact atgagaagct caaaactgac     2400

attaaggtgg ttgacagaga ttctgaagaa gccgagatca tcaggaagta tgttaagaac     2460

actcatgcaa ccacacacaa tgcgtatgac ttggaagtca tcgatatctt taagatagag     2520

cgtgaaggcg aatgccagcg ttacaagccc tttaagcagc ttcataaccg aagattgctg     2580

tggcacgggt ccaggaccac caactttgct gggatcctgt cccagggtct tcggatagcc     2640

ccgcctgaag cgcccgtgac aggctacatg tttggtaaag ggatctattt cgctgacatg     2700

gtctccaaga gtgccaacta ctgccatacg tctcagggag acccaatagg cttaatcctg     2760

ttgggagaag ttgcccttgg aaacatgtat gaactgaagc acgcttcaca tatcagcaag     2820

ttacccaagg gcaagcacag tgtcaaaggt ttgggcaaaa ctacccctga tccttcagct     2880

aacattagtc tggatggtgt agacgttcct cttgggaccg ggatttcatc tggtgtgaat     2940

gacacctctc tactatataa cgagtacatt gtctatgata ttgctcaggt aaatctgaag     3000

tatctgctga aactgaaatt caattttaag acctccctgt ggtaa                     3045


<210>  43
<211>  1014
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser 
1               5                   10                  15      


Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser 
            20                  25                  30          


Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val 
        35                  40                  45              


Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile 
    50                  55                  60                  


Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp 
65                  70                  75                  80  


Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly 
                85                  90                  95      


Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp 
            100                 105                 110         


Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys 
        115                 120                 125             


Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val 
    130                 135                 140                 


Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro 
145                 150                 155                 160 


Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr 
                165                 170                 175     


Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys 
            180                 185                 190         


Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg 
        195                 200                 205             


Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser 
    210                 215                 220                 


Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala 
225                 230                 235                 240 


Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys 
                245                 250                 255     


Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val 
            260                 265                 270         


Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val 
        275                 280                 285             


Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe 
    290                 295                 300                 


Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys 
305                 310                 315                 320 


Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro 
                325                 330                 335     


Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys 
            340                 345                 350         


Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr 
        355                 360                 365             


Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala 
    370                 375                 380                 


Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys 
385                 390                 395                 400 


Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly 
                405                 410                 415     


Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr 
            420                 425                 430         


Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu 
        435                 440                 445             


Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala 
    450                 455                 460                 


Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro 
465                 470                 475                 480 


Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg 
                485                 490                 495     


Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys 
            500                 505                 510         


Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys 
        515                 520                 525             


Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His 
    530                 535                 540                 


Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val 
545                 550                 555                 560 


Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu 
                565                 570                 575     


Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val 
            580                 585                 590         


Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu 
        595                 600                 605             


Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn 
    610                 615                 620                 


Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro 
625                 630                 635                 640 


Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr 
                645                 650                 655     


Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu 
            660                 665                 670         


Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu 
        675                 680                 685             


Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg 
    690                 695                 700                 


Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val 
705                 710                 715                 720 


Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe 
                725                 730                 735     


Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu 
            740                 745                 750         


Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu 
        755                 760                 765             


Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp 
    770                 775                 780                 


Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp 
785                 790                 795                 800 


Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys 
                805                 810                 815     


Tyr Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu 
            820                 825                 830         


Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr 
        835                 840                 845             


Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser 
    850                 855                 860                 


Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala 
865                 870                 875                 880 


Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr 
                885                 890                 895     


Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln 
            900                 905                 910         


Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn 
        915                 920                 925             


Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly 
    930                 935                 940                 


Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala 
945                 950                 955                 960 


Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser 
                965                 970                 975     


Ser Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr 
            980                 985                 990         


Asp Ile Ala Gln Val Asn Leu Lys  Tyr Leu Leu Lys Leu  Lys Phe Asn 
        995                 1000                 1005             


Phe Lys  Thr Ser Leu Trp 
    1010                 


<210>  44
<211>  1851
<212>  DNA
<213>  Homo sapiens

<400>  44
atggtcggcc aactgagcga gggggccatt gcggccatca tgcagaaggg ggatacaaac       60

ataaagccca tcctccaagt catcaacatc cgtcccatta ctacggggaa tagtccgccg      120

cgttatcgac tgctcatgag tgatggattg aacactctat cctctttcat gttggcgaca      180

cagttgaacc ctctcgtgga ggaagaacaa ttgtccagca actgtgtatg ccagattcac      240

agatttattg tgaacactct gaaagacgga aggagagtag ttatcttgat ggaattagaa      300

gttttgaagt cagctgaagc agttggagtg aagattggca atccagtgcc ctataatgaa      360

ggactcgggc agccgcaagt agctcctcca gcgccagcag ccagcccagc agcaagcagc      420

aggccccagc cgcagaatgg aagctcggga atgggttcta ctgtttctaa ggcttatggt      480

gcttcaaaga catttggaaa agctgcaggt cccagcctgt cacacacttc tgggggaaca      540

cagtccaaag tggtgcccat tgccagcctc actccttacc agtccaagtg gaccatttgt      600

gctcgtgtta ccaacaaaag tcagatccgt acctggagca actcccgagg ggaagggaag      660

cttttctccc tagaactggt tgacgaaagt ggtgaaatcc gagctacagc tttcaatgag      720

caagtggaca agttctttcc tcttattgaa gtgaacaagg tgtattattt ctcgaaaggc      780

accctgaaga ttgctaacaa gcagttcaca gctgttaaaa atgactacga gatgaccttc      840

aataacgaga cttccgtcat gccctgtgag gacgaccatc atttacctac ggttcagttt      900

gatttcacgg ggattgatga cctcgagaac aagtcgaaag actcacttgt agacatcatc      960

gggatctgca agagctatga agacgccact aaaatcacag tgaggtctaa caacagagaa     1020

gttgccaaga ggaatatcta cttgatggac acatccggga aggtggtgac tgctacactg     1080

tggggggaag atgctgataa atttgatggt tctagacagc ccgtgttggc tatcaaagga     1140

gcccgagtct ctgatttcgg tggacggagc ctctccgtgc tgtcttcaag cactatcatt     1200

gcgaatcctg acatcccaga ggcctataag cttcgtggat ggtttgacgc agaaggacaa     1260

gccttagatg gtgtttccat ctctgatcta aagagcggcg gagtcggagg gagtaacacc     1320

aactggaaaa ccttgtatga ggtcaaatcc gagaacctgg gccaaggcga caagccggac     1380

tactttagtt ctgtggccac agtggtgtat cttcgcaaag agaactgcat gtaccaagcc     1440

tgcccgactc aggactgcaa taagaaagtg attgatcaac agaatggatt gtaccgctgt     1500

gagaagtgcg acaccgaatt tcccaatttc aagtaccgca tgatcctgtc agtaaatatt     1560

gcagattttc aagagaatca gtgggtgact tgtttccagg agtctgctga agctatcctt     1620

ggacaaaatg ctgcttatct tggggaatta aaagacaaga atgaacaggc atttgaagaa     1680

gttttccaga atgccaactt ccgatctttc atattcagag tcagggtcaa agtggagacc     1740

tacaacgacg agtctcgaat taaggccact gtgatggacg tgaagcccgt ggactacaga     1800

gagtatggcc gaaggctggt catgagcatc aggagaagtg cattgatgtg a              1851


<210>  45
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Val Gly Gln Leu Ser Glu Gly Ala Ile Ala Ala Ile Met Gln Lys 
1               5                   10                  15      


Gly Asp Thr Asn Ile Lys Pro Ile Leu Gln Val Ile Asn Ile Arg Pro 
            20                  25                  30          


Ile Thr Thr Gly Asn Ser Pro Pro Arg Tyr Arg Leu Leu Met Ser Asp 
        35                  40                  45              


Gly Leu Asn Thr Leu Ser Ser Phe Met Leu Ala Thr Gln Leu Asn Pro 
    50                  55                  60                  


Leu Val Glu Glu Glu Gln Leu Ser Ser Asn Cys Val Cys Gln Ile His 
65                  70                  75                  80  


Arg Phe Ile Val Asn Thr Leu Lys Asp Gly Arg Arg Val Val Ile Leu 
                85                  90                  95      


Met Glu Leu Glu Val Leu Lys Ser Ala Glu Ala Val Gly Val Lys Ile 
            100                 105                 110         


Gly Asn Pro Val Pro Tyr Asn Glu Gly Leu Gly Gln Pro Gln Val Ala 
        115                 120                 125             


Pro Pro Ala Pro Ala Ala Ser Pro Ala Ala Ser Ser Arg Pro Gln Pro 
    130                 135                 140                 


Gln Asn Gly Ser Ser Gly Met Gly Ser Thr Val Ser Lys Ala Tyr Gly 
145                 150                 155                 160 


Ala Ser Lys Thr Phe Gly Lys Ala Ala Gly Pro Ser Leu Ser His Thr 
                165                 170                 175     


Ser Gly Gly Thr Gln Ser Lys Val Val Pro Ile Ala Ser Leu Thr Pro 
            180                 185                 190         


Tyr Gln Ser Lys Trp Thr Ile Cys Ala Arg Val Thr Asn Lys Ser Gln 
        195                 200                 205             


Ile Arg Thr Trp Ser Asn Ser Arg Gly Glu Gly Lys Leu Phe Ser Leu 
    210                 215                 220                 


Glu Leu Val Asp Glu Ser Gly Glu Ile Arg Ala Thr Ala Phe Asn Glu 
225                 230                 235                 240 


Gln Val Asp Lys Phe Phe Pro Leu Ile Glu Val Asn Lys Val Tyr Tyr 
                245                 250                 255     


Phe Ser Lys Gly Thr Leu Lys Ile Ala Asn Lys Gln Phe Thr Ala Val 
            260                 265                 270         


Lys Asn Asp Tyr Glu Met Thr Phe Asn Asn Glu Thr Ser Val Met Pro 
        275                 280                 285             


Cys Glu Asp Asp His His Leu Pro Thr Val Gln Phe Asp Phe Thr Gly 
    290                 295                 300                 


Ile Asp Asp Leu Glu Asn Lys Ser Lys Asp Ser Leu Val Asp Ile Ile 
305                 310                 315                 320 


Gly Ile Cys Lys Ser Tyr Glu Asp Ala Thr Lys Ile Thr Val Arg Ser 
                325                 330                 335     


Asn Asn Arg Glu Val Ala Lys Arg Asn Ile Tyr Leu Met Asp Thr Ser 
            340                 345                 350         


Gly Lys Val Val Thr Ala Thr Leu Trp Gly Glu Asp Ala Asp Lys Phe 
        355                 360                 365             


Asp Gly Ser Arg Gln Pro Val Leu Ala Ile Lys Gly Ala Arg Val Ser 
    370                 375                 380                 


Asp Phe Gly Gly Arg Ser Leu Ser Val Leu Ser Ser Ser Thr Ile Ile 
385                 390                 395                 400 


Ala Asn Pro Asp Ile Pro Glu Ala Tyr Lys Leu Arg Gly Trp Phe Asp 
                405                 410                 415     


Ala Glu Gly Gln Ala Leu Asp Gly Val Ser Ile Ser Asp Leu Lys Ser 
            420                 425                 430         


Gly Gly Val Gly Gly Ser Asn Thr Asn Trp Lys Thr Leu Tyr Glu Val 
        435                 440                 445             


Lys Ser Glu Asn Leu Gly Gln Gly Asp Lys Pro Asp Tyr Phe Ser Ser 
    450                 455                 460                 


Val Ala Thr Val Val Tyr Leu Arg Lys Glu Asn Cys Met Tyr Gln Ala 
465                 470                 475                 480 


Cys Pro Thr Gln Asp Cys Asn Lys Lys Val Ile Asp Gln Gln Asn Gly 
                485                 490                 495     


Leu Tyr Arg Cys Glu Lys Cys Asp Thr Glu Phe Pro Asn Phe Lys Tyr 
            500                 505                 510         


Arg Met Ile Leu Ser Val Asn Ile Ala Asp Phe Gln Glu Asn Gln Trp 
        515                 520                 525             


Val Thr Cys Phe Gln Glu Ser Ala Glu Ala Ile Leu Gly Gln Asn Ala 
    530                 535                 540                 


Ala Tyr Leu Gly Glu Leu Lys Asp Lys Asn Glu Gln Ala Phe Glu Glu 
545                 550                 555                 560 


Val Phe Gln Asn Ala Asn Phe Arg Ser Phe Ile Phe Arg Val Arg Val 
                565                 570                 575     


Lys Val Glu Thr Tyr Asn Asp Glu Ser Arg Ile Lys Ala Thr Val Met 
            580                 585                 590         


Asp Val Lys Pro Val Asp Tyr Arg Glu Tyr Gly Arg Arg Leu Val Met 
        595                 600                 605             


Ser Ile Arg Arg Ser Ala Leu Met 
    610                 615     


<210>  46
<211>  1812
<212>  DNA
<213>  Homo sapiens

<400>  46
atgcagaagg gggatacaaa cataaagccc atcctccaag tcatcaacat ccgtcccatt       60

actacgggga atagtccgcc gcgttatcga ctgctcatga gtgatggatt gaacactcta      120

tcctctttca tgttggcgac acagttgaac cctctcgtgg aggaagaaca attgtccagc      180

aactgtgtat gccagattca cagatttatt gtgaacactc tgaaagacgg aaggagagta      240

gttatcttga tggaattaga agttttgaag tcagctgaag cagttggagt gaagattggc      300

aatccagtgc cctataatga aggactcggg cagccgcaag tagctcctcc agcgccagca      360

gccagcccag cagcaagcag caggccccag ccgcagaatg gaagctcggg aatgggttct      420

actgtttcta aggcttatgg tgcttcaaag acatttggaa aagctgcagg tcccagcctg      480

tcacacactt ctgggggaac acagtccaaa gtggtgccca ttgccagcct cactccttac      540

cagtccaagt ggaccatttg tgctcgtgtt accaacaaaa gtcagatccg tacctggagc      600

aactcccgag gggaagggaa gcttttctcc ctagaactgg ttgacgaaag tggtgaaatc      660

cgagctacag ctttcaatga gcaagtggac aagttctttc ctcttattga agtgaacaag      720

gtgtattatt tctcgaaagg caccctgaag attgctaaca agcagttcac agctgttaaa      780

aatgactacg agatgacctt caataacgag acttccgtca tgccctgtga ggacgaccat      840

catttaccta cggttcagtt tgatttcacg gggattgatg acctcgagaa caagtcgaaa      900

gactcacttg tagacatcat cgggatctgc aagagctatg aagacgccac taaaatcaca      960

gtgaggtcta acaacagaga agttgccaag aggaatatct acttgatgga cacatccggg     1020

aaggtggtga ctgctacact gtggggggaa gatgctgata aatttgatgg ttctagacag     1080

cccgtgttgg ctatcaaagg agcccgagtc tctgatttcg gtggacggag cctctccgtg     1140

ctgtcttcaa gcactatcat tgcgaatcct gacatcccag aggcctataa gcttcgtgga     1200

tggtttgacg cagaaggaca agccttagat ggtgtttcca tctctgatct aaagagcggc     1260

ggagtcggag ggagtaacac caactggaaa accttgtatg aggtcaaatc cgagaacctg     1320

ggccaaggcg acaagccgga ctactttagt tctgtggcca cagtggtgta tcttcgcaaa     1380

gagaactgca tgtaccaagc ctgcccgact caggactgca ataagaaagt gattgatcaa     1440

cagaatggat tgtaccgctg tgagaagtgc gacaccgaat ttcccaattt caagtaccgc     1500

atgatcctgt cagtaaatat tgcagatttt caagagaatc agtgggtgac ttgtttccag     1560

gagtctgctg aagctatcct tggacaaaat gctgcttatc ttggggaatt aaaagacaag     1620

aatgaacagg catttgaaga agttttccag aatgccaact tccgatcttt catattcaga     1680

gtcagggtca aagtggagac ctacaacgac gagtctcgaa ttaaggccac tgtgatggac     1740

gtgaagcccg tggactacag agagtatggc cgaaggctgg tcatgagcat caggagaagt     1800

gcattgatgt ga                                                         1812


<210>  47
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gln Lys Gly Asp Thr Asn Ile Lys Pro Ile Leu Gln Val Ile Asn 
1               5                   10                  15      


Ile Arg Pro Ile Thr Thr Gly Asn Ser Pro Pro Arg Tyr Arg Leu Leu 
            20                  25                  30          


Met Ser Asp Gly Leu Asn Thr Leu Ser Ser Phe Met Leu Ala Thr Gln 
        35                  40                  45              


Leu Asn Pro Leu Val Glu Glu Glu Gln Leu Ser Ser Asn Cys Val Cys 
    50                  55                  60                  


Gln Ile His Arg Phe Ile Val Asn Thr Leu Lys Asp Gly Arg Arg Val 
65                  70                  75                  80  


Val Ile Leu Met Glu Leu Glu Val Leu Lys Ser Ala Glu Ala Val Gly 
                85                  90                  95      


Val Lys Ile Gly Asn Pro Val Pro Tyr Asn Glu Gly Leu Gly Gln Pro 
            100                 105                 110         


Gln Val Ala Pro Pro Ala Pro Ala Ala Ser Pro Ala Ala Ser Ser Arg 
        115                 120                 125             


Pro Gln Pro Gln Asn Gly Ser Ser Gly Met Gly Ser Thr Val Ser Lys 
    130                 135                 140                 


Ala Tyr Gly Ala Ser Lys Thr Phe Gly Lys Ala Ala Gly Pro Ser Leu 
145                 150                 155                 160 


Ser His Thr Ser Gly Gly Thr Gln Ser Lys Val Val Pro Ile Ala Ser 
                165                 170                 175     


Leu Thr Pro Tyr Gln Ser Lys Trp Thr Ile Cys Ala Arg Val Thr Asn 
            180                 185                 190         


Lys Ser Gln Ile Arg Thr Trp Ser Asn Ser Arg Gly Glu Gly Lys Leu 
        195                 200                 205             


Phe Ser Leu Glu Leu Val Asp Glu Ser Gly Glu Ile Arg Ala Thr Ala 
    210                 215                 220                 


Phe Asn Glu Gln Val Asp Lys Phe Phe Pro Leu Ile Glu Val Asn Lys 
225                 230                 235                 240 


Val Tyr Tyr Phe Ser Lys Gly Thr Leu Lys Ile Ala Asn Lys Gln Phe 
                245                 250                 255     


Thr Ala Val Lys Asn Asp Tyr Glu Met Thr Phe Asn Asn Glu Thr Ser 
            260                 265                 270         


Val Met Pro Cys Glu Asp Asp His His Leu Pro Thr Val Gln Phe Asp 
        275                 280                 285             


Phe Thr Gly Ile Asp Asp Leu Glu Asn Lys Ser Lys Asp Ser Leu Val 
    290                 295                 300                 


Asp Ile Ile Gly Ile Cys Lys Ser Tyr Glu Asp Ala Thr Lys Ile Thr 
305                 310                 315                 320 


Val Arg Ser Asn Asn Arg Glu Val Ala Lys Arg Asn Ile Tyr Leu Met 
                325                 330                 335     


Asp Thr Ser Gly Lys Val Val Thr Ala Thr Leu Trp Gly Glu Asp Ala 
            340                 345                 350         


Asp Lys Phe Asp Gly Ser Arg Gln Pro Val Leu Ala Ile Lys Gly Ala 
        355                 360                 365             


Arg Val Ser Asp Phe Gly Gly Arg Ser Leu Ser Val Leu Ser Ser Ser 
    370                 375                 380                 


Thr Ile Ile Ala Asn Pro Asp Ile Pro Glu Ala Tyr Lys Leu Arg Gly 
385                 390                 395                 400 


Trp Phe Asp Ala Glu Gly Gln Ala Leu Asp Gly Val Ser Ile Ser Asp 
                405                 410                 415     


Leu Lys Ser Gly Gly Val Gly Gly Ser Asn Thr Asn Trp Lys Thr Leu 
            420                 425                 430         


Tyr Glu Val Lys Ser Glu Asn Leu Gly Gln Gly Asp Lys Pro Asp Tyr 
        435                 440                 445             


Phe Ser Ser Val Ala Thr Val Val Tyr Leu Arg Lys Glu Asn Cys Met 
    450                 455                 460                 


Tyr Gln Ala Cys Pro Thr Gln Asp Cys Asn Lys Lys Val Ile Asp Gln 
465                 470                 475                 480 


Gln Asn Gly Leu Tyr Arg Cys Glu Lys Cys Asp Thr Glu Phe Pro Asn 
                485                 490                 495     


Phe Lys Tyr Arg Met Ile Leu Ser Val Asn Ile Ala Asp Phe Gln Glu 
            500                 505                 510         


Asn Gln Trp Val Thr Cys Phe Gln Glu Ser Ala Glu Ala Ile Leu Gly 
        515                 520                 525             


Gln Asn Ala Ala Tyr Leu Gly Glu Leu Lys Asp Lys Asn Glu Gln Ala 
    530                 535                 540                 


Phe Glu Glu Val Phe Gln Asn Ala Asn Phe Arg Ser Phe Ile Phe Arg 
545                 550                 555                 560 


Val Arg Val Lys Val Glu Thr Tyr Asn Asp Glu Ser Arg Ile Lys Ala 
                565                 570                 575     


Thr Val Met Asp Val Lys Pro Val Asp Tyr Arg Glu Tyr Gly Arg Arg 
            580                 585                 590         


Leu Val Met Ser Ile Arg Arg Ser Ala Leu Met 
        595                 600             


<210>  48
<211>  1674
<212>  DNA
<213>  Homo sapiens

<400>  48
atggtcggcc aactgagcga gggggccatt gcggccatca tgcagaaggg ggatacaaac       60

ataaagccca tcctccaagt catcaacatc cgtcccatta ctacggggaa tagtccgccg      120

cgttatcgac tgctcatgag tgatggattg aacactctat cctctttcat gttggcgaca      180

cagttgaacc ctctcgtgga ggaagaacaa ttgtccagca actgtgtatg ccagattcac      240

agatttattg tgaacactct gaaagacgga aggagagtag ttatcttgat ggaattagaa      300

gttttgaagt cagctgaagc agttggagtg aagattggca atccagtgcc ctataatgaa      360

ggactcgggc agccgcaagt agctcctcca gcgccagcag ccagcccagc agcaagcagc      420

aggccccagc cgcagaatgg aagctcggga atgggttcta ctgtttctaa ggcttatggt      480

gcttcaaaga catttggaaa agctgcaggt cccagcctgt cacacacttc tgggggaaca      540

cagtccaaag tggtgcccat tgccagcctc actccttacc agtccaagtg gaccatttgt      600

gctcgtgtta ccaacaaaag tcagatccgt acctggagca actcccgagg ggaagggaag      660

cttttctccc tagaactggt tgacgaaagt ggtgaaatcc gagctacagc tttcaatgag      720

caagtggaca agttctttcc tcttattgaa gtgaacaagg tgtattattt ctcgaaaggc      780

accctgaaga ttgctaacaa gcagttcaca gctgttaaaa atgactacga gatgaccttc      840

aataacgaga cttccgtcat gccctgtgag gacgaccatc atttacctac ggttcagttt      900

gatttcacgg ggattgatga cctcgagaac aagtcgaaag actcacttgt agacatcatc      960

gggatctgca agagctatga agacgccact aaaatcacag tgaggtctaa caacagagaa     1020

gttgccaaga ggaatatcta cttgatggac acatccggga aggtggtgac tgctacactg     1080

tggggggaag atgctgataa atttgatggt tctagacagc ccgtgttggc tatcaaagga     1140

gcccgagtct ctgatttcgg tggacggagc ctctccgtgc tgtcttcaag cactatcatt     1200

gcgaatcctg acatcccaga ggcctataag cttcgtggat ggtttgacgc agaaggacaa     1260

gccttagatg gtgtttccat ctctgatcta aagagcggcg gagtcggagg gagtaacacc     1320

aactggaaaa ccttgtatga ggtcaaatcc gagaacctgg gccaaggcga caaggtaaat     1380

attgcagatt ttcaagagaa tcagtgggtg acttgtttcc aggagtctgc tgaagctatc     1440

cttggacaaa atgctgctta tcttggggaa ttaaaagaca agaatgaaca ggcatttgaa     1500

gaagttttcc agaatgccaa cttccgatct ttcatattca gagtcagggt caaagtggag     1560

acctacaacg acgagtctcg aattaaggcc actgtgatgg acgtgaagcc cgtggactac     1620

agagagtatg gccgaaggct ggtcatgagc atcaggagaa gtgcattgat gtga           1674


<210>  49
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Val Gly Gln Leu Ser Glu Gly Ala Ile Ala Ala Ile Met Gln Lys 
1               5                   10                  15      


Gly Asp Thr Asn Ile Lys Pro Ile Leu Gln Val Ile Asn Ile Arg Pro 
            20                  25                  30          


Ile Thr Thr Gly Asn Ser Pro Pro Arg Tyr Arg Leu Leu Met Ser Asp 
        35                  40                  45              


Gly Leu Asn Thr Leu Ser Ser Phe Met Leu Ala Thr Gln Leu Asn Pro 
    50                  55                  60                  


Leu Val Glu Glu Glu Gln Leu Ser Ser Asn Cys Val Cys Gln Ile His 
65                  70                  75                  80  


Arg Phe Ile Val Asn Thr Leu Lys Asp Gly Arg Arg Val Val Ile Leu 
                85                  90                  95      


Met Glu Leu Glu Val Leu Lys Ser Ala Glu Ala Val Gly Val Lys Ile 
            100                 105                 110         


Gly Asn Pro Val Pro Tyr Asn Glu Gly Leu Gly Gln Pro Gln Val Ala 
        115                 120                 125             


Pro Pro Ala Pro Ala Ala Ser Pro Ala Ala Ser Ser Arg Pro Gln Pro 
    130                 135                 140                 


Gln Asn Gly Ser Ser Gly Met Gly Ser Thr Val Ser Lys Ala Tyr Gly 
145                 150                 155                 160 


Ala Ser Lys Thr Phe Gly Lys Ala Ala Gly Pro Ser Leu Ser His Thr 
                165                 170                 175     


Ser Gly Gly Thr Gln Ser Lys Val Val Pro Ile Ala Ser Leu Thr Pro 
            180                 185                 190         


Tyr Gln Ser Lys Trp Thr Ile Cys Ala Arg Val Thr Asn Lys Ser Gln 
        195                 200                 205             


Ile Arg Thr Trp Ser Asn Ser Arg Gly Glu Gly Lys Leu Phe Ser Leu 
    210                 215                 220                 


Glu Leu Val Asp Glu Ser Gly Glu Ile Arg Ala Thr Ala Phe Asn Glu 
225                 230                 235                 240 


Gln Val Asp Lys Phe Phe Pro Leu Ile Glu Val Asn Lys Val Tyr Tyr 
                245                 250                 255     


Phe Ser Lys Gly Thr Leu Lys Ile Ala Asn Lys Gln Phe Thr Ala Val 
            260                 265                 270         


Lys Asn Asp Tyr Glu Met Thr Phe Asn Asn Glu Thr Ser Val Met Pro 
        275                 280                 285             


Cys Glu Asp Asp His His Leu Pro Thr Val Gln Phe Asp Phe Thr Gly 
    290                 295                 300                 


Ile Asp Asp Leu Glu Asn Lys Ser Lys Asp Ser Leu Val Asp Ile Ile 
305                 310                 315                 320 


Gly Ile Cys Lys Ser Tyr Glu Asp Ala Thr Lys Ile Thr Val Arg Ser 
                325                 330                 335     


Asn Asn Arg Glu Val Ala Lys Arg Asn Ile Tyr Leu Met Asp Thr Ser 
            340                 345                 350         


Gly Lys Val Val Thr Ala Thr Leu Trp Gly Glu Asp Ala Asp Lys Phe 
        355                 360                 365             


Asp Gly Ser Arg Gln Pro Val Leu Ala Ile Lys Gly Ala Arg Val Ser 
    370                 375                 380                 


Asp Phe Gly Gly Arg Ser Leu Ser Val Leu Ser Ser Ser Thr Ile Ile 
385                 390                 395                 400 


Ala Asn Pro Asp Ile Pro Glu Ala Tyr Lys Leu Arg Gly Trp Phe Asp 
                405                 410                 415     


Ala Glu Gly Gln Ala Leu Asp Gly Val Ser Ile Ser Asp Leu Lys Ser 
            420                 425                 430         


Gly Gly Val Gly Gly Ser Asn Thr Asn Trp Lys Thr Leu Tyr Glu Val 
        435                 440                 445             


Lys Ser Glu Asn Leu Gly Gln Gly Asp Lys Val Asn Ile Ala Asp Phe 
    450                 455                 460                 


Gln Glu Asn Gln Trp Val Thr Cys Phe Gln Glu Ser Ala Glu Ala Ile 
465                 470                 475                 480 


Leu Gly Gln Asn Ala Ala Tyr Leu Gly Glu Leu Lys Asp Lys Asn Glu 
                485                 490                 495     


Gln Ala Phe Glu Glu Val Phe Gln Asn Ala Asn Phe Arg Ser Phe Ile 
            500                 505                 510         


Phe Arg Val Arg Val Lys Val Glu Thr Tyr Asn Asp Glu Ser Arg Ile 
        515                 520                 525             


Lys Ala Thr Val Met Asp Val Lys Pro Val Asp Tyr Arg Glu Tyr Gly 
    530                 535                 540                 


Arg Arg Leu Val Met Ser Ile Arg Arg Ser Ala Leu Met 
545                 550                 555         


<210>  50
<211>  1020
<212>  DNA
<213>  Homo sapiens

<400>  50
atggcaatgc agatgcagct tgaagcaaat gcagatactt cagtggaaga agaaagcttt       60

ggcccacaac ccatttcacg gttagagcag tgtggcataa atgccaacga tgtgaagaaa      120

ttggaagaag ctggattcca tactgtggag gctgttgcct atgcgccaaa gaaggagcta      180

ataaatatta agggaattag tgaagccaaa gctgataaaa ttctggctga ggcagctaaa      240

ttagttccaa tgggtttcac cactgcaact gaattccacc aaaggcggtc agagatcata      300

cagattacta ctggctccaa agagcttgac aaactacttc aaggtggaat tgagactgga      360

tctatcacag aaatgtttgg agaattccga actgggaaga cccagatctg tcatacgcta      420

gctgtcacct gccagcttcc cattgaccgg ggtggaggtg aaggaaaggc catgtacatt      480

gacactgagg gtacctttag gccagaacgg ctgctggcag tggctgagag gtatggtctc      540

tctggcagtg atgtcctgga taatgtagca tatgctcgag cgttcaacac agaccaccag      600

acccagctcc tttatcaagc atcagccatg atggtagaat ctaggtatgc actgcttatt      660

gtagacagtg ccaccgccct ttacagaaca gactactcgg gtcgaggtga gctttcagcc      720

aggcagatgc acttggccag gtttctgcgg atgcttctgc gactcgctga tgagtttggt      780

gtagcagtgg taatcactaa tcaggtggta gctcaagtgg atggagcagc gatgtttgct      840

gctgatccca aaaaacctat tggaggaaat atcatcgccc atgcatcaac aaccagattg      900

tatctgagga aaggaagagg ggaaaccaga atctgcaaaa tctacgactc tccctgtctt      960

cctgaagctg aagctatgtt cgccattaat gcagatggag tgggagatgc caaagactga     1020


<210>  51
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  52
<211>  1023
<212>  DNA
<213>  Homo sapiens

<400>  52
atggcaatgc agatgcagct tgaagcaaat gcagatactt cagtggaaga agaaagcttt       60

ggcccacaac ccatttcacg gttagagcag tgtggcataa atgccaacga tgtgaagaaa      120

ttggaagaag ctggattcca tactgtggag gctgttgcct atgcgccaaa gaaggagcta      180

ataaatatta agggaattag tgaagccaaa gctgataaaa ttctgacgga gtctcgctct      240

gttgccaggc tggagtgcaa tagcgtgatc ttggtctact gcaccctccg cctctcaggt      300

tcaagtgatt ctcctgcctc agcctcccga gtagttggga ctacaggtgg aattgagact      360

ggatctatca cagaaatgtt tggagaattc cgaactggga agacccagat ctgtcatacg      420

ctagctgtca cctgccagct tcccattgac cggggtggag gtgaaggaaa ggccatgtac      480

attgacactg agggtacctt taggccagaa cggctgctgg cagtggctga gaggtatggt      540

ctctctggca gtgatgtcct ggataatgta gcatatgctc gagcgttcaa cacagaccac      600

cagacccagc tcctttatca agcatcagcc atgatggtag aatctaggta tgcactgctt      660

attgtagaca gtgccaccgc cctttacaga acagactact cgggtcgagg tgagctttca      720

gccaggcaga tgcacttggc caggtttctg cggatgcttc tgcgactcgc tgatgagttt      780

ggtgtagcag tggtaatcac taatcaggtg gtagctcaag tggatggagc agcgatgttt      840

gctgctgatc ccaaaaaacc tattggagga aatatcatcg cccatgcatc aacaaccaga      900

ttgtatctga ggaaaggaag aggggaaacc agaatctgca aaatctacga ctctccctgt      960

cttcctgaag ctgaagctat gttcgccatt aatgcagatg gagtgggaga tgccaaagac     1020

tga                                                                   1023


<210>  53
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ser Arg Ser 
65                  70                  75                  80  


Val Ala Arg Leu Glu Cys Asn Ser Val Ile Leu Val Tyr Cys Thr Leu 
                85                  90                  95      


Arg Leu Ser Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val Val 
            100                 105                 110         


Gly Thr Thr Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly 
        115                 120                 125             


Glu Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr 
    130                 135                 140                 


Cys Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr 
145                 150                 155                 160 


Ile Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala 
                165                 170                 175     


Glu Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr 
            180                 185                 190         


Ala Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala 
        195                 200                 205             


Ser Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser 
    210                 215                 220                 


Ala Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser 
225                 230                 235                 240 


Ala Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu 
                245                 250                 255     


Ala Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala 
            260                 265                 270         


Gln Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile 
        275                 280                 285             


Gly Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg 
    290                 295                 300                 


Lys Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys 
305                 310                 315                 320 


Leu Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly 
                325                 330                 335     


Asp Ala Lys Asp 
            340 


<210>  54
<211>  843
<212>  DNA
<213>  Homo sapiens

<400>  54
atggcaatgc agatgcagct tgaagcaaat gcagatactt cagtggaaga agaaagcttt       60

ggcccacaac ccatttcacg gttagagcag tgtggcataa atgccaacga tgtgaagaaa      120

ttggaagaag ctggattcca tactgtggag gctgttgcct atgcgccaaa gaaggagcta      180

ataaatatta agggaattag tgaagccaaa gctgataaaa ttctggctga ggcagctaaa      240

ttagttccaa tgggtttcac cactgcaact gaattccacc aaaggcggtc agagatcata      300

cagattacta ctggctccaa agagcttgac aaactacttc aaggtggaat tgagactgga      360

tctatcacag aaatgtttgg agaattccga actgggaaga cccagatctg tcatacgcta      420

gctgtcacct gccagcttcc cattgaccgg ggtggaggtg aaggaaaggc catgtacatt      480

gacactgagg gtacctttag gccagaacgg ctgctggcag tggctgagag gtatggtctc      540

tctggcagtg atgtcctgga taatgtagca tatgctcgag cgttcaacac agaccaccag      600

acccagctcc tttatcaagc atcagccatg atggtagaat ctaggtatgc actgcttatt      660

gtagacagtg ccaccgccct ttacagaaca gactactcgg gtcgaggtga gctttcagcc      720

aggcagatgc acttggccag gtttctgcgg atgcttctgc gactcgctga tgagattgta      780

tctgaggaaa ggaagagggg aaaccagaat ctgcaaaatc tacgactctc cctgtcttcc      840

tga                                                                    843


<210>  55
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Ile Val Ser Glu Glu Arg Lys Arg Gly Asn Gln Asn Leu Gln 
            260                 265                 270         


Asn Leu Arg Leu Ser Leu Ser Ser 
        275                 280 


<210>  56
<211>  1659
<212>  DNA
<213>  Homo sapiens

<400>  56
atggcggccc cggtccgcct gggccggaag cgcccgctgc ctgcctgtcc caacccgctc       60

ttcgttcgct ggctgaccga gtggcgggac gaggcgaccc gcagcaggcg ccgcacgcgc      120

ttcgtatttc agaaggcgct gcgttccctc cgacggtacc cactgccgct gcgcagcggg      180

aaggaagcta agatcctaca gcacttcgga gacgggctct gccggatgct ggacgagcgg      240

ctgcagcggc accgaacatc gggcggtgac catgccccgg actcaccatc tggagagaac      300

agtccagccc cgcaggggcg acttgcggaa gtccaggact cttccatgcc agttcctgcc      360

cagcccaaag cgggaggctc tggcagctac tggccagctc ggcactcagg agcccgagtg      420

atactgctgg tgctctaccg ggagcacctg aatcctaatg gtcaccactt cttaaccaag      480

gaggagctgc tgcagaggtg tgctcagaag tcccccaggg tagcccctgg gagtgctcga      540

ccctggccag ccctccgctc cctccttcac aggaacctgg tcctcaggac acaccagcca      600

gccaggtact cattgacccc agagggcctg gagctggccc agaagttggc cgagtcagaa      660

ggcctgagct tgctgaatgt gggcatcggg cccaaggagc cccctgggga ggagacagca      720

gtgccaggag cagcttcagc agagcttgcc agtgaagcag gggtccagca gcagccactg      780

gagctgaggc ctggagagta cagggtgctg ttgtgtgtgg acattggcga gacccggggg      840

ggcgggcaca ggccggagct gctccgagag ctacagcggc tgcacgtgac ccacacggtg      900

cgcaagctgc acgttggaga ttttgtgtgg gtggcccagg agaccaatcc tagagaccca      960

gcagcaaacc ctggggagtt ggtactggat cacattgtgg agcgcaagcg actggatgac     1020

ctttgcagca gcatcatcga cggccgcttc cgggagcaga agttccggct gaagcgctgt     1080

ggtctggagc gccgggtata cctggtggaa gagcatggtt ccgtccacaa cctcagcctt     1140

cctgagagca cactgctgca ggctgtcacc aacactcagg tcattgatgg cttttttgtg     1200

aagcgcacag cagacattaa ggagtcagcc gcctacctgg ccctcttgac gcggggcctg     1260

cagagactct accagggcca caccctacgc agccgcccct ggggaacccc tgggaaccct     1320

gaatcagggg ccatgacctc tccaaaccct ctctgctcac tcctcacctt cagtgacttc     1380

aacgcaggag ccatcaagaa taaggcccag tcggtgcgag aagtgtttgc ccggcagctg     1440

atgcaggtgc gcggagtgag tggggagaag gcagcagccc tggtggatcg atacagcacc     1500

cctgccagcc tcctggccgc ctatgatgcc tgtgccaccc ccaaggaaca agagacactg     1560

ctgagcacca ttaagtgtgg gcgtctacag aggaatctgg ggcctgctct gagcaggacc     1620

ttatcccagc tctactgcag ctacggcccc ttgacctga                            1659


<210>  57
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Ala Pro Val Arg Leu Gly Arg Lys Arg Pro Leu Pro Ala Cys 
1               5                   10                  15      


Pro Asn Pro Leu Phe Val Arg Trp Leu Thr Glu Trp Arg Asp Glu Ala 
            20                  25                  30          


Thr Arg Ser Arg Arg Arg Thr Arg Phe Val Phe Gln Lys Ala Leu Arg 
        35                  40                  45              


Ser Leu Arg Arg Tyr Pro Leu Pro Leu Arg Ser Gly Lys Glu Ala Lys 
    50                  55                  60                  


Ile Leu Gln His Phe Gly Asp Gly Leu Cys Arg Met Leu Asp Glu Arg 
65                  70                  75                  80  


Leu Gln Arg His Arg Thr Ser Gly Gly Asp His Ala Pro Asp Ser Pro 
                85                  90                  95      


Ser Gly Glu Asn Ser Pro Ala Pro Gln Gly Arg Leu Ala Glu Val Gln 
            100                 105                 110         


Asp Ser Ser Met Pro Val Pro Ala Gln Pro Lys Ala Gly Gly Ser Gly 
        115                 120                 125             


Ser Tyr Trp Pro Ala Arg His Ser Gly Ala Arg Val Ile Leu Leu Val 
    130                 135                 140                 


Leu Tyr Arg Glu His Leu Asn Pro Asn Gly His His Phe Leu Thr Lys 
145                 150                 155                 160 


Glu Glu Leu Leu Gln Arg Cys Ala Gln Lys Ser Pro Arg Val Ala Pro 
                165                 170                 175     


Gly Ser Ala Arg Pro Trp Pro Ala Leu Arg Ser Leu Leu His Arg Asn 
            180                 185                 190         


Leu Val Leu Arg Thr His Gln Pro Ala Arg Tyr Ser Leu Thr Pro Glu 
        195                 200                 205             


Gly Leu Glu Leu Ala Gln Lys Leu Ala Glu Ser Glu Gly Leu Ser Leu 
    210                 215                 220                 


Leu Asn Val Gly Ile Gly Pro Lys Glu Pro Pro Gly Glu Glu Thr Ala 
225                 230                 235                 240 


Val Pro Gly Ala Ala Ser Ala Glu Leu Ala Ser Glu Ala Gly Val Gln 
                245                 250                 255     


Gln Gln Pro Leu Glu Leu Arg Pro Gly Glu Tyr Arg Val Leu Leu Cys 
            260                 265                 270         


Val Asp Ile Gly Glu Thr Arg Gly Gly Gly His Arg Pro Glu Leu Leu 
        275                 280                 285             


Arg Glu Leu Gln Arg Leu His Val Thr His Thr Val Arg Lys Leu His 
    290                 295                 300                 


Val Gly Asp Phe Val Trp Val Ala Gln Glu Thr Asn Pro Arg Asp Pro 
305                 310                 315                 320 


Ala Ala Asn Pro Gly Glu Leu Val Leu Asp His Ile Val Glu Arg Lys 
                325                 330                 335     


Arg Leu Asp Asp Leu Cys Ser Ser Ile Ile Asp Gly Arg Phe Arg Glu 
            340                 345                 350         


Gln Lys Phe Arg Leu Lys Arg Cys Gly Leu Glu Arg Arg Val Tyr Leu 
        355                 360                 365             


Val Glu Glu His Gly Ser Val His Asn Leu Ser Leu Pro Glu Ser Thr 
    370                 375                 380                 


Leu Leu Gln Ala Val Thr Asn Thr Gln Val Ile Asp Gly Phe Phe Val 
385                 390                 395                 400 


Lys Arg Thr Ala Asp Ile Lys Glu Ser Ala Ala Tyr Leu Ala Leu Leu 
                405                 410                 415     


Thr Arg Gly Leu Gln Arg Leu Tyr Gln Gly His Thr Leu Arg Ser Arg 
            420                 425                 430         


Pro Trp Gly Thr Pro Gly Asn Pro Glu Ser Gly Ala Met Thr Ser Pro 
        435                 440                 445             


Asn Pro Leu Cys Ser Leu Leu Thr Phe Ser Asp Phe Asn Ala Gly Ala 
    450                 455                 460                 


Ile Lys Asn Lys Ala Gln Ser Val Arg Glu Val Phe Ala Arg Gln Leu 
465                 470                 475                 480 


Met Gln Val Arg Gly Val Ser Gly Glu Lys Ala Ala Ala Leu Val Asp 
                485                 490                 495     


Arg Tyr Ser Thr Pro Ala Ser Leu Leu Ala Ala Tyr Asp Ala Cys Ala 
            500                 505                 510         


Thr Pro Lys Glu Gln Glu Thr Leu Leu Ser Thr Ile Lys Cys Gly Arg 
        515                 520                 525             


Leu Gln Arg Asn Leu Gly Pro Ala Leu Ser Arg Thr Leu Ser Gln Leu 
    530                 535                 540                 


Tyr Cys Ser Tyr Gly Pro Leu Thr 
545                 550         


<210>  58
<211>  1656
<212>  DNA
<213>  Homo sapiens

<400>  58
atggcggccc cggtccgcct gggccggaag cgcccgctgc ctgcctgtcc caacccgctc       60

ttcgttcgct ggctgaccga gtggcgggac gaggcgaccc gcagcaggcg ccgcacgcgc      120

ttcgtatttc agaaggcgct gcgttccctc cgacggtacc cactgccgct gcgcagcggg      180

aaggaagcta agatcctaca gcacttcgga gacgggctct gccggatgct ggacgagcgg      240

ctgcagcggc accgaacatc gggcggtgac catgccccgg actcaccatc tggagagaac      300

agtccagccc cgcaggggcg acttgcggaa gtccaggact cttccatgcc agttcctgcc      360

cagcccaaag cgggaggctc tggcagctac tggccagctc ggcactcagg agcccgagtg      420

atactgctgg tgctctaccg ggagcacctg aatcctaatg gtcaccactt cttaaccaag      480

gaggagctgc tgcagaggtg tgctcagaag tcccccaggg tagcccctgg gagtgctcga      540

ccctggccag ccctccgctc cctccttcac aggaacctgg tcctcaggac acaccagcca      600

gccaggtact cattgacccc agagggcctg gagctggccc agaagttggc cgagtcagaa      660

ggcctgagct tgctgaatgt gggcatcggg cccaaggagc cccctgggga ggagacagca      720

gtgccaggag cagcttcagc agagcttgcc agtgaagcag gggtccagca gcagccactg      780

gagctgaggc ctggagagta cagggtgctg ttgtgtgtgg acattggcga gacccggggg      840

ggcgggcaca ggccggagct gctccgagag ctacagcggc tgcacgtgac ccacacggtg      900

cgcaagctgc acgttggaga ttttgtgtgg gtggcccagg agaccaatcc tagagaccca      960

gcaaaccctg gggagttggt actggatcac attgtggagc gcaagcgact ggatgacctt     1020

tgcagcagca tcatcgacgg ccgcttccgg gagcagaagt tccggctgaa gcgctgtggt     1080

ctggagcgcc gggtatacct ggtggaagag catggttccg tccacaacct cagccttcct     1140

gagagcacac tgctgcaggc tgtcaccaac actcaggtca ttgatggctt ttttgtgaag     1200

cgcacagcag acattaagga gtcagccgcc tacctggccc tcttgacgcg gggcctgcag     1260

agactctacc agggccacac cctacgcagc cgcccctggg gaacccctgg gaaccctgaa     1320

tcaggggcca tgacctctcc aaaccctctc tgctcactcc tcaccttcag tgacttcaac     1380

gcaggagcca tcaagaataa ggcccagtcg gtgcgagaag tgtttgcccg gcagctgatg     1440

caggtgcgcg gagtgagtgg ggagaaggca gcagccctgg tggatcgata cagcacccct     1500

gccagcctcc tggccgccta tgatgcctgt gccaccccca aggaacaaga gacactgctg     1560

agcaccatta agtgtgggcg tctacagagg aatctggggc ctgctctgag caggacctta     1620

tcccagctct actgcagcta cggccccttg acctga                               1656


<210>  59
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ala Ala Pro Val Arg Leu Gly Arg Lys Arg Pro Leu Pro Ala Cys 
1               5                   10                  15      


Pro Asn Pro Leu Phe Val Arg Trp Leu Thr Glu Trp Arg Asp Glu Ala 
            20                  25                  30          


Thr Arg Ser Arg Arg Arg Thr Arg Phe Val Phe Gln Lys Ala Leu Arg 
        35                  40                  45              


Ser Leu Arg Arg Tyr Pro Leu Pro Leu Arg Ser Gly Lys Glu Ala Lys 
    50                  55                  60                  


Ile Leu Gln His Phe Gly Asp Gly Leu Cys Arg Met Leu Asp Glu Arg 
65                  70                  75                  80  


Leu Gln Arg His Arg Thr Ser Gly Gly Asp His Ala Pro Asp Ser Pro 
                85                  90                  95      


Ser Gly Glu Asn Ser Pro Ala Pro Gln Gly Arg Leu Ala Glu Val Gln 
            100                 105                 110         


Asp Ser Ser Met Pro Val Pro Ala Gln Pro Lys Ala Gly Gly Ser Gly 
        115                 120                 125             


Ser Tyr Trp Pro Ala Arg His Ser Gly Ala Arg Val Ile Leu Leu Val 
    130                 135                 140                 


Leu Tyr Arg Glu His Leu Asn Pro Asn Gly His His Phe Leu Thr Lys 
145                 150                 155                 160 


Glu Glu Leu Leu Gln Arg Cys Ala Gln Lys Ser Pro Arg Val Ala Pro 
                165                 170                 175     


Gly Ser Ala Arg Pro Trp Pro Ala Leu Arg Ser Leu Leu His Arg Asn 
            180                 185                 190         


Leu Val Leu Arg Thr His Gln Pro Ala Arg Tyr Ser Leu Thr Pro Glu 
        195                 200                 205             


Gly Leu Glu Leu Ala Gln Lys Leu Ala Glu Ser Glu Gly Leu Ser Leu 
    210                 215                 220                 


Leu Asn Val Gly Ile Gly Pro Lys Glu Pro Pro Gly Glu Glu Thr Ala 
225                 230                 235                 240 


Val Pro Gly Ala Ala Ser Ala Glu Leu Ala Ser Glu Ala Gly Val Gln 
                245                 250                 255     


Gln Gln Pro Leu Glu Leu Arg Pro Gly Glu Tyr Arg Val Leu Leu Cys 
            260                 265                 270         


Val Asp Ile Gly Glu Thr Arg Gly Gly Gly His Arg Pro Glu Leu Leu 
        275                 280                 285             


Arg Glu Leu Gln Arg Leu His Val Thr His Thr Val Arg Lys Leu His 
    290                 295                 300                 


Val Gly Asp Phe Val Trp Val Ala Gln Glu Thr Asn Pro Arg Asp Pro 
305                 310                 315                 320 


Ala Asn Pro Gly Glu Leu Val Leu Asp His Ile Val Glu Arg Lys Arg 
                325                 330                 335     


Leu Asp Asp Leu Cys Ser Ser Ile Ile Asp Gly Arg Phe Arg Glu Gln 
            340                 345                 350         


Lys Phe Arg Leu Lys Arg Cys Gly Leu Glu Arg Arg Val Tyr Leu Val 
        355                 360                 365             


Glu Glu His Gly Ser Val His Asn Leu Ser Leu Pro Glu Ser Thr Leu 
    370                 375                 380                 


Leu Gln Ala Val Thr Asn Thr Gln Val Ile Asp Gly Phe Phe Val Lys 
385                 390                 395                 400 


Arg Thr Ala Asp Ile Lys Glu Ser Ala Ala Tyr Leu Ala Leu Leu Thr 
                405                 410                 415     


Arg Gly Leu Gln Arg Leu Tyr Gln Gly His Thr Leu Arg Ser Arg Pro 
            420                 425                 430         


Trp Gly Thr Pro Gly Asn Pro Glu Ser Gly Ala Met Thr Ser Pro Asn 
        435                 440                 445             


Pro Leu Cys Ser Leu Leu Thr Phe Ser Asp Phe Asn Ala Gly Ala Ile 
    450                 455                 460                 


Lys Asn Lys Ala Gln Ser Val Arg Glu Val Phe Ala Arg Gln Leu Met 
465                 470                 475                 480 


Gln Val Arg Gly Val Ser Gly Glu Lys Ala Ala Ala Leu Val Asp Arg 
                485                 490                 495     


Tyr Ser Thr Pro Ala Ser Leu Leu Ala Ala Tyr Asp Ala Cys Ala Thr 
            500                 505                 510         


Pro Lys Glu Gln Glu Thr Leu Leu Ser Thr Ile Lys Cys Gly Arg Leu 
        515                 520                 525             


Gln Arg Asn Leu Gly Pro Ala Leu Ser Arg Thr Leu Ser Gln Leu Tyr 
    530                 535                 540                 


Cys Ser Tyr Gly Pro Leu Thr 
545                 550     


<210>  60
<211>  2358
<212>  DNA
<213>  Homo sapiens

<400>  60
atgggaaaaa aatacaagaa cattgttcta ctaaaaggat tagaggtcat caatgattat       60

cattttagaa tggttaagtc cttactgagc aacgatttaa aacttaattt aaaaatgaga      120

gaagagtatg acaaaattca gattgctgac ttgatggaag aaaagttccg aggtgatgct      180

ggtttgggca aactaataaa aattttcgaa gatataccaa cgcttgaaga cctggctgaa      240

actcttaaaa aagaaaagtt aaaagtaaaa ggaccagccc tatcaagaaa gaggaagaag      300

gaagtggatg ctacttcacc tgcaccctcc acaagcagca ctgtcaaaac tgaaggagca      360

gaggcaactc ctggagctca gaaaagaaaa aaatcaacca aagaaaaggc tggacccaaa      420

gggagtaagg tgtccgagga acagactcag cctccctctc ctgcaggagc cggcatgtcc      480

acagccatgg gccgttcccc atctcccaag acctcattgt cagctccacc caacagttct      540

tcaactgaga acccgaaaac agtggccaaa tgtcaggtaa ctcccagaag aaatgttctc      600

caaaaacgcc cagtgatagt gaaggtactg agtacaacaa agccatttga atatgagacc      660

ccagaaatgg agaaaaaaat aatgtttcat gctacagtgg ctacacagac acagttcttc      720

catgtgaagg ttttaaacac cagcttgaag gagaaattca atggaaagaa aatcatcatc      780

atatcagatt atttggaata tgatagtctc ctagaggtca atgaagaatc tactgtatct      840

gaagctggtc ctaaccaaac gtttgaggtt ccaaataaaa tcatcaacag agcaaaggaa      900

actctgaaga ttgatattct tcacaaacaa gcttcaggaa atattgtata tggggtattt      960

atgctacata agaaaacagt aaatcagaag accacaatct acgaaattca ggatgataga     1020

ggaaaaatgg atgtagtggg gacaggacaa tgtcacaata tcccctgtga agaaggagat     1080

aagctccaac ttttctgctt tcgacttaga aaaaagaacc agatgtcaaa actgatttca     1140

gaaatgcata gttttatcca gataaagaaa aaaacaaacc cgagaaacaa tgaccccaag     1200

agcatgaagc taccccagga acagcgtcag cttccatatc cttcagaggc cagcacaacc     1260

ttccctgaga gccatcttcg gactcctcag atgccaccaa caactccatc cagcagtttc     1320

ttcaccaaga aaagtgaaga cacaatctcc aaaatgaatg acttcatgag gatgcagata     1380

ctgaaggaag ggagtcattt tccaggaccg ttcatgacca gcataggccc agctgagagc     1440

catccccaca ctcctcagat gcctccatca acaccaagca gcagtttctt aaccacgaaa     1500

agtgaagaca caatctccaa aatgaatgac ttcatgagga tgcagatact gaaggaaggg     1560

agtcattttc caggaccgtt catgaccagc ataggcccag ctgagagcca tccccacact     1620

cctcagatgc ctccatcaac accaagcagc agtttcttaa ccacgttgaa accaagactg     1680

aagactgaac ctgaagaagt ttccatagaa gacagtgccc agagtgacct caaagaagtg     1740

atggtgctga acgcaacaga atcatttgta tatgagccca aagagcagaa gaaaatgttt     1800

catgccacag tggcaactga gaatgaagtc ttccgagtga aggtttttaa tattgaccta     1860

aaggagaagt tcaccccaaa gaagatcatt gccatagcaa attatgtttg ccgcaatggg     1920

ttcctggagg tatatccttt cacacttgtg gctgatgtga atgctgaccg aaacatggag     1980

atcccaaaag gattgattag aagtgccagc gtaactccta aaatcaatca gctttgctca     2040

caaactaaag gaagttttgt gaatggggtg tttgaggtac ataagaaaaa tgtaaggggt     2100

gaattcactt attatgaaat acaagataat acagggaaga tggaagtggt ggtgcatgga     2160

cgactgacca caatcaactg tgaggaagga gataaactga aactcacctg ctttgaattg     2220

gcaccgaaaa gtgggaatac cggggagttg agatctgtaa ttcatagtca catcaaggtc     2280

atcaagacca ggaaaaacaa gaaagacata ctcaatcctg attcaagtat ggaaacttca     2340

ccagactttt tcttctaa                                                   2358


<210>  61
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg 
                85                  90                  95      


Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala Pro Ser Thr Ser 
            100                 105                 110         


Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Lys 
        115                 120                 125             


Arg Lys Lys Ser Thr Lys Glu Lys Ala Gly Pro Lys Gly Ser Lys Val 
    130                 135                 140                 


Ser Glu Glu Gln Thr Gln Pro Pro Ser Pro Ala Gly Ala Gly Met Ser 
145                 150                 155                 160 


Thr Ala Met Gly Arg Ser Pro Ser Pro Lys Thr Ser Leu Ser Ala Pro 
                165                 170                 175     


Pro Asn Ser Ser Ser Thr Glu Asn Pro Lys Thr Val Ala Lys Cys Gln 
            180                 185                 190         


Val Thr Pro Arg Arg Asn Val Leu Gln Lys Arg Pro Val Ile Val Lys 
        195                 200                 205             


Val Leu Ser Thr Thr Lys Pro Phe Glu Tyr Glu Thr Pro Glu Met Glu 
    210                 215                 220                 


Lys Lys Ile Met Phe His Ala Thr Val Ala Thr Gln Thr Gln Phe Phe 
225                 230                 235                 240 


His Val Lys Val Leu Asn Thr Ser Leu Lys Glu Lys Phe Asn Gly Lys 
                245                 250                 255     


Lys Ile Ile Ile Ile Ser Asp Tyr Leu Glu Tyr Asp Ser Leu Leu Glu 
            260                 265                 270         


Val Asn Glu Glu Ser Thr Val Ser Glu Ala Gly Pro Asn Gln Thr Phe 
        275                 280                 285             


Glu Val Pro Asn Lys Ile Ile Asn Arg Ala Lys Glu Thr Leu Lys Ile 
    290                 295                 300                 


Asp Ile Leu His Lys Gln Ala Ser Gly Asn Ile Val Tyr Gly Val Phe 
305                 310                 315                 320 


Met Leu His Lys Lys Thr Val Asn Gln Lys Thr Thr Ile Tyr Glu Ile 
                325                 330                 335     


Gln Asp Asp Arg Gly Lys Met Asp Val Val Gly Thr Gly Gln Cys His 
            340                 345                 350         


Asn Ile Pro Cys Glu Glu Gly Asp Lys Leu Gln Leu Phe Cys Phe Arg 
        355                 360                 365             


Leu Arg Lys Lys Asn Gln Met Ser Lys Leu Ile Ser Glu Met His Ser 
    370                 375                 380                 


Phe Ile Gln Ile Lys Lys Lys Thr Asn Pro Arg Asn Asn Asp Pro Lys 
385                 390                 395                 400 


Ser Met Lys Leu Pro Gln Glu Gln Arg Gln Leu Pro Tyr Pro Ser Glu 
                405                 410                 415     


Ala Ser Thr Thr Phe Pro Glu Ser His Leu Arg Thr Pro Gln Met Pro 
            420                 425                 430         


Pro Thr Thr Pro Ser Ser Ser Phe Phe Thr Lys Lys Ser Glu Asp Thr 
        435                 440                 445             


Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly 
    450                 455                 460                 


Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser 
465                 470                 475                 480 


His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe 
                485                 490                 495     


Leu Thr Thr Lys Ser Glu Asp Thr Ile Ser Lys Met Asn Asp Phe Met 
            500                 505                 510         


Arg Met Gln Ile Leu Lys Glu Gly Ser His Phe Pro Gly Pro Phe Met 
        515                 520                 525             


Thr Ser Ile Gly Pro Ala Glu Ser His Pro His Thr Pro Gln Met Pro 
    530                 535                 540                 


Pro Ser Thr Pro Ser Ser Ser Phe Leu Thr Thr Leu Lys Pro Arg Leu 
545                 550                 555                 560 


Lys Thr Glu Pro Glu Glu Val Ser Ile Glu Asp Ser Ala Gln Ser Asp 
                565                 570                 575     


Leu Lys Glu Val Met Val Leu Asn Ala Thr Glu Ser Phe Val Tyr Glu 
            580                 585                 590         


Pro Lys Glu Gln Lys Lys Met Phe His Ala Thr Val Ala Thr Glu Asn 
        595                 600                 605             


Glu Val Phe Arg Val Lys Val Phe Asn Ile Asp Leu Lys Glu Lys Phe 
    610                 615                 620                 


Thr Pro Lys Lys Ile Ile Ala Ile Ala Asn Tyr Val Cys Arg Asn Gly 
625                 630                 635                 640 


Phe Leu Glu Val Tyr Pro Phe Thr Leu Val Ala Asp Val Asn Ala Asp 
                645                 650                 655     


Arg Asn Met Glu Ile Pro Lys Gly Leu Ile Arg Ser Ala Ser Val Thr 
            660                 665                 670         


Pro Lys Ile Asn Gln Leu Cys Ser Gln Thr Lys Gly Ser Phe Val Asn 
        675                 680                 685             


Gly Val Phe Glu Val His Lys Lys Asn Val Arg Gly Glu Phe Thr Tyr 
    690                 695                 700                 


Tyr Glu Ile Gln Asp Asn Thr Gly Lys Met Glu Val Val Val His Gly 
705                 710                 715                 720 


Arg Leu Thr Thr Ile Asn Cys Glu Glu Gly Asp Lys Leu Lys Leu Thr 
                725                 730                 735     


Cys Phe Glu Leu Ala Pro Lys Ser Gly Asn Thr Gly Glu Leu Arg Ser 
            740                 745                 750         


Val Ile His Ser His Ile Lys Val Ile Lys Thr Arg Lys Asn Lys Lys 
        755                 760                 765             


Asp Ile Leu Asn Pro Asp Ser Ser Met Glu Thr Ser Pro Asp Phe Phe 
    770                 775                 780                 


Phe 
785 


<210>  62
<211>  2190
<212>  DNA
<213>  Homo sapiens

<400>  62
atgggaaaaa aatacaagaa cattgttcta ctaaaaggat tagaggtcat caatgattat       60

cattttagaa tggttaagtc cttactgagc aacgatttaa aacttaattt aaaaatgaga      120

gaagagtatg acaaaattca gattgctgac ttgatggaag aaaagttccg aggtgatgct      180

ggtttgggca aactaataaa aattttcgaa gatataccaa cgcttgaaga cctggctgaa      240

actcttaaaa aagaaaagtt aaaagtaaaa ggaccagccc tatcaagaaa gaggaagaag      300

gaagtggatg ctacttcacc tgcaccctcc acaagcagca ctgtcaaaac tgaaggagca      360

gaggcaactc ctggagctca gaaaagaaaa aaatcaacca aagaaaaggc tggacccaaa      420

gggagtaagg tgtccgagga acagactcag cctccctctc ctgcaggagc cggcatgtcc      480

acagccatgg gccgttcccc atctcccaag acctcattgt cagctccacc caacagttct      540

tcaactgaga acccgaaaac agtggccaaa tgtcaggtaa ctcccagaag aaatgttctc      600

caaaaacgcc cagtgatagt gaaggtactg agtacaacaa agccatttga atatgagacc      660

ccagaaatgg agaaaaaaat aatgtttcat gctacagtgg ctacacagac acagttcttc      720

catgtgaagg ttttaaacac cagcttgaag gagaaattca atggaaagaa aatcatcatc      780

atatcagatt atttggaata tgatagtctc ctagaggtca atgaagaatc tactgtatct      840

gaagctggtc ctaaccaaac gtttgaggtt ccaaataaaa tcatcaacag agcaaaggaa      900

actctgaaga ttgatattct tcacaaacaa gcttcaggaa atattgtata tggggtattt      960

atgctacata agaaaacagt aaatcagaag accacaatct acgaaattca ggatgataga     1020

ggaaaaatgg atgtagtggg gacaggacaa tgtcacaata tcccctgtga agaaggagat     1080

aagctccaac ttttctgctt tcgacttaga aaaaagaacc agatgtcaaa actgatttca     1140

gaaatgcata gttttatcca gataaagaaa aaaacaaacc cgagaaacaa tgaccccaag     1200

agcatgaagc taccccagga acagcgtcag cttccatatc cttcagaggc cagcacaacc     1260

ttccctgaga gccatcttcg gactcctcag atgccaccaa caactccatc cagcagtttc     1320

ttcaccaaga aaagtgaaga cacaatctcc aaaatgaatg acttcatgag gatgcagata     1380

ctgaaggaag ggagtcattt tccaggaccg ttcatgacca gcataggccc agctgagagc     1440

catccccaca ctcctcagat gcctccatca acaccaagca gcagtttctt aaccacgttg     1500

aaaccaagac tgaagactga acctgaagaa gtttccatag aagacagtgc ccagagtgac     1560

ctcaaagaag tgatggtgct gaacgcaaca gaatcatttg tatatgagcc caaagagcag     1620

aagaaaatgt ttcatgccac agtggcaact gagaatgaag tcttccgagt gaaggttttt     1680

aatattgacc taaaggagaa gttcacccca aagaagatca ttgccatagc aaattatgtt     1740

tgccgcaatg ggttcctgga ggtatatcct ttcacacttg tggctgatgt gaatgctgac     1800

cgaaacatgg agatcccaaa aggattgatt agaagtgcca gcgtaactcc taaaatcaat     1860

cagctttgct cacaaactaa aggaagtttt gtgaatgggg tgtttgaggt acataagaaa     1920

aatgtaaggg gtgaattcac ttattatgaa atacaagata atacagggaa gatggaagtg     1980

gtggtgcatg gacgactgac cacaatcaac tgtgaggaag gagataaact gaaactcacc     2040

tgctttgaat tggcaccgaa aagtgggaat accggggagt tgagatctgt aattcatagt     2100

cacatcaagg tcatcaagac caggaaaaac aagaaagaca tactcaatcc tgattcaagt     2160

atggaaactt caccagactt tttcttctaa                                      2190


<210>  63
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg 
                85                  90                  95      


Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala Pro Ser Thr Ser 
            100                 105                 110         


Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Lys 
        115                 120                 125             


Arg Lys Lys Ser Thr Lys Glu Lys Ala Gly Pro Lys Gly Ser Lys Val 
    130                 135                 140                 


Ser Glu Glu Gln Thr Gln Pro Pro Ser Pro Ala Gly Ala Gly Met Ser 
145                 150                 155                 160 


Thr Ala Met Gly Arg Ser Pro Ser Pro Lys Thr Ser Leu Ser Ala Pro 
                165                 170                 175     


Pro Asn Ser Ser Ser Thr Glu Asn Pro Lys Thr Val Ala Lys Cys Gln 
            180                 185                 190         


Val Thr Pro Arg Arg Asn Val Leu Gln Lys Arg Pro Val Ile Val Lys 
        195                 200                 205             


Val Leu Ser Thr Thr Lys Pro Phe Glu Tyr Glu Thr Pro Glu Met Glu 
    210                 215                 220                 


Lys Lys Ile Met Phe His Ala Thr Val Ala Thr Gln Thr Gln Phe Phe 
225                 230                 235                 240 


His Val Lys Val Leu Asn Thr Ser Leu Lys Glu Lys Phe Asn Gly Lys 
                245                 250                 255     


Lys Ile Ile Ile Ile Ser Asp Tyr Leu Glu Tyr Asp Ser Leu Leu Glu 
            260                 265                 270         


Val Asn Glu Glu Ser Thr Val Ser Glu Ala Gly Pro Asn Gln Thr Phe 
        275                 280                 285             


Glu Val Pro Asn Lys Ile Ile Asn Arg Ala Lys Glu Thr Leu Lys Ile 
    290                 295                 300                 


Asp Ile Leu His Lys Gln Ala Ser Gly Asn Ile Val Tyr Gly Val Phe 
305                 310                 315                 320 


Met Leu His Lys Lys Thr Val Asn Gln Lys Thr Thr Ile Tyr Glu Ile 
                325                 330                 335     


Gln Asp Asp Arg Gly Lys Met Asp Val Val Gly Thr Gly Gln Cys His 
            340                 345                 350         


Asn Ile Pro Cys Glu Glu Gly Asp Lys Leu Gln Leu Phe Cys Phe Arg 
        355                 360                 365             


Leu Arg Lys Lys Asn Gln Met Ser Lys Leu Ile Ser Glu Met His Ser 
    370                 375                 380                 


Phe Ile Gln Ile Lys Lys Lys Thr Asn Pro Arg Asn Asn Asp Pro Lys 
385                 390                 395                 400 


Ser Met Lys Leu Pro Gln Glu Gln Arg Gln Leu Pro Tyr Pro Ser Glu 
                405                 410                 415     


Ala Ser Thr Thr Phe Pro Glu Ser His Leu Arg Thr Pro Gln Met Pro 
            420                 425                 430         


Pro Thr Thr Pro Ser Ser Ser Phe Phe Thr Lys Lys Ser Glu Asp Thr 
        435                 440                 445             


Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly 
    450                 455                 460                 


Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser 
465                 470                 475                 480 


His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe 
                485                 490                 495     


Leu Thr Thr Leu Lys Pro Arg Leu Lys Thr Glu Pro Glu Glu Val Ser 
            500                 505                 510         


Ile Glu Asp Ser Ala Gln Ser Asp Leu Lys Glu Val Met Val Leu Asn 
        515                 520                 525             


Ala Thr Glu Ser Phe Val Tyr Glu Pro Lys Glu Gln Lys Lys Met Phe 
    530                 535                 540                 


His Ala Thr Val Ala Thr Glu Asn Glu Val Phe Arg Val Lys Val Phe 
545                 550                 555                 560 


Asn Ile Asp Leu Lys Glu Lys Phe Thr Pro Lys Lys Ile Ile Ala Ile 
                565                 570                 575     


Ala Asn Tyr Val Cys Arg Asn Gly Phe Leu Glu Val Tyr Pro Phe Thr 
            580                 585                 590         


Leu Val Ala Asp Val Asn Ala Asp Arg Asn Met Glu Ile Pro Lys Gly 
        595                 600                 605             


Leu Ile Arg Ser Ala Ser Val Thr Pro Lys Ile Asn Gln Leu Cys Ser 
    610                 615                 620                 


Gln Thr Lys Gly Ser Phe Val Asn Gly Val Phe Glu Val His Lys Lys 
625                 630                 635                 640 


Asn Val Arg Gly Glu Phe Thr Tyr Tyr Glu Ile Gln Asp Asn Thr Gly 
                645                 650                 655     


Lys Met Glu Val Val Val His Gly Arg Leu Thr Thr Ile Asn Cys Glu 
            660                 665                 670         


Glu Gly Asp Lys Leu Lys Leu Thr Cys Phe Glu Leu Ala Pro Lys Ser 
        675                 680                 685             


Gly Asn Thr Gly Glu Leu Arg Ser Val Ile His Ser His Ile Lys Val 
    690                 695                 700                 


Ile Lys Thr Arg Lys Asn Lys Lys Asp Ile Leu Asn Pro Asp Ser Ser 
705                 710                 715                 720 


Met Glu Thr Ser Pro Asp Phe Phe Phe 
                725                 


<210>  64
<211>  2190
<212>  DNA
<213>  Homo sapiens

<400>  64
atgggaaaaa aatacaagaa cattgttcta ctaaaaggat tagaggtcat caatgattat       60

cattttagaa tggttaagtc cttactgagc aacgatttaa aacttaattt aaaaatgaga      120

gaagagtatg acaaaattca gattgctgac ttgatggaag aaaagttccg aggtgatgct      180

ggtttgggca aactaataaa aattttcgaa gatataccaa cgcttgaaga cctggctgaa      240

actcttaaaa aagaaaagtt aaaagtaaaa ggaccagccc tatcaagaaa gaggaagaag      300

gaagtggatg ctacttcacc tgcaccctcc acaagcagca ctgtcaaaac tgaaggagca      360

gaggcaactc ctggagctca gaacccgaaa acagtggcca aatgtcaggt aactcccaga      420

agaaatgttc tccaaaaacg cccagtgata gtgaaggtac tgagtacaac aaagccattt      480

gaatatgaga ccccagaaat ggagaaaaaa ataatgtttc atgctacagt ggctacacag      540

acacagttct tccatgtgaa ggttttaaac accagcttga aggagaaatt caatggaaag      600

aaaatcatca tcatatcaga ttatttggaa tatgatagtc tcctagaggt caatgaagaa      660

tctactgtat ctgaagctgg tcctaaccaa acgtttgagg ttccaaataa aatcatcaac      720

agagcaaagg aaactctgaa gattgatatt cttcacaaac aagcttcagg aaatattgta      780

tatggggtat ttatgctaca taagaaaaca gtaaatcaga agaccacaat ctacgaaatt      840

caggatgata gaggaaaaat ggatgtagtg gggacaggac aatgtcacaa tatcccctgt      900

gaagaaggag ataagctcca acttttctgc tttcgactta gaaaaaagaa ccagatgtca      960

aaactgattt cagaaatgca tagttttatc cagataaaga aaaaaacaaa cccgagaaac     1020

aatgacccca agagcatgaa gctaccccag gaacagcgtc agcttccata tccttcagag     1080

gccagcacaa ccttccctga gagccatctt cggactcctc agatgccacc aacaactcca     1140

tccagcagtt tcttcaccaa gaaaagtgaa gacacaatct ccaaaatgaa tgacttcatg     1200

aggatgcaga tactgaagga agggagtcat tttccaggac cgttcatgac cagcataggc     1260

ccagctgaga gccatcccca cactcctcag atgcctccat caacaccaag cagcagtttc     1320

ttaaccacga aaagtgaaga cacaatctcc aaaatgaatg acttcatgag gatgcagata     1380

ctgaaggaag ggagtcattt tccaggaccg ttcatgacca gcataggccc agctgagagc     1440

catccccaca ctcctcagat gcctccatca acaccaagca gcagtttctt aaccacgttg     1500

aaaccaagac tgaagactga acctgaagaa gtttccatag aagacagtgc ccagagtgac     1560

ctcaaagaag tgatggtgct gaacgcaaca gaatcatttg tatatgagcc caaagagcag     1620

aagaaaatgt ttcatgccac agtggcaact gagaatgaag tcttccgagt gaaggttttt     1680

aatattgacc taaaggagaa gttcacccca aagaagatca ttgccatagc aaattatgtt     1740

tgccgcaatg ggttcctgga ggtatatcct ttcacacttg tggctgatgt gaatgctgac     1800

cgaaacatgg agatcccaaa aggattgatt agaagtgcca gcgtaactcc taaaatcaat     1860

cagctttgct cacaaactaa aggaagtttt gtgaatgggg tgtttgaggt acataagaaa     1920

aatgtaaggg gtgaattcac ttattatgaa atacaagata atacagggaa gatggaagtg     1980

gtggtgcatg gacgactgac cacaatcaac tgtgaggaag gagataaact gaaactcacc     2040

tgctttgaat tggcaccgaa aagtgggaat accggggagt tgagatctgt aattcatagt     2100

cacatcaagg tcatcaagac caggaaaaac aagaaagaca tactcaatcc tgattcaagt     2160

atggaaactt caccagactt tttcttctaa                                      2190


<210>  65
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg 
                85                  90                  95      


Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala Pro Ser Thr Ser 
            100                 105                 110         


Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Asn 
        115                 120                 125             


Pro Lys Thr Val Ala Lys Cys Gln Val Thr Pro Arg Arg Asn Val Leu 
    130                 135                 140                 


Gln Lys Arg Pro Val Ile Val Lys Val Leu Ser Thr Thr Lys Pro Phe 
145                 150                 155                 160 


Glu Tyr Glu Thr Pro Glu Met Glu Lys Lys Ile Met Phe His Ala Thr 
                165                 170                 175     


Val Ala Thr Gln Thr Gln Phe Phe His Val Lys Val Leu Asn Thr Ser 
            180                 185                 190         


Leu Lys Glu Lys Phe Asn Gly Lys Lys Ile Ile Ile Ile Ser Asp Tyr 
        195                 200                 205             


Leu Glu Tyr Asp Ser Leu Leu Glu Val Asn Glu Glu Ser Thr Val Ser 
    210                 215                 220                 


Glu Ala Gly Pro Asn Gln Thr Phe Glu Val Pro Asn Lys Ile Ile Asn 
225                 230                 235                 240 


Arg Ala Lys Glu Thr Leu Lys Ile Asp Ile Leu His Lys Gln Ala Ser 
                245                 250                 255     


Gly Asn Ile Val Tyr Gly Val Phe Met Leu His Lys Lys Thr Val Asn 
            260                 265                 270         


Gln Lys Thr Thr Ile Tyr Glu Ile Gln Asp Asp Arg Gly Lys Met Asp 
        275                 280                 285             


Val Val Gly Thr Gly Gln Cys His Asn Ile Pro Cys Glu Glu Gly Asp 
    290                 295                 300                 


Lys Leu Gln Leu Phe Cys Phe Arg Leu Arg Lys Lys Asn Gln Met Ser 
305                 310                 315                 320 


Lys Leu Ile Ser Glu Met His Ser Phe Ile Gln Ile Lys Lys Lys Thr 
                325                 330                 335     


Asn Pro Arg Asn Asn Asp Pro Lys Ser Met Lys Leu Pro Gln Glu Gln 
            340                 345                 350         


Arg Gln Leu Pro Tyr Pro Ser Glu Ala Ser Thr Thr Phe Pro Glu Ser 
        355                 360                 365             


His Leu Arg Thr Pro Gln Met Pro Pro Thr Thr Pro Ser Ser Ser Phe 
    370                 375                 380                 


Phe Thr Lys Lys Ser Glu Asp Thr Ile Ser Lys Met Asn Asp Phe Met 
385                 390                 395                 400 


Arg Met Gln Ile Leu Lys Glu Gly Ser His Phe Pro Gly Pro Phe Met 
                405                 410                 415     


Thr Ser Ile Gly Pro Ala Glu Ser His Pro His Thr Pro Gln Met Pro 
            420                 425                 430         


Pro Ser Thr Pro Ser Ser Ser Phe Leu Thr Thr Lys Ser Glu Asp Thr 
        435                 440                 445             


Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly 
    450                 455                 460                 


Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser 
465                 470                 475                 480 


His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe 
                485                 490                 495     


Leu Thr Thr Leu Lys Pro Arg Leu Lys Thr Glu Pro Glu Glu Val Ser 
            500                 505                 510         


Ile Glu Asp Ser Ala Gln Ser Asp Leu Lys Glu Val Met Val Leu Asn 
        515                 520                 525             


Ala Thr Glu Ser Phe Val Tyr Glu Pro Lys Glu Gln Lys Lys Met Phe 
    530                 535                 540                 


His Ala Thr Val Ala Thr Glu Asn Glu Val Phe Arg Val Lys Val Phe 
545                 550                 555                 560 


Asn Ile Asp Leu Lys Glu Lys Phe Thr Pro Lys Lys Ile Ile Ala Ile 
                565                 570                 575     


Ala Asn Tyr Val Cys Arg Asn Gly Phe Leu Glu Val Tyr Pro Phe Thr 
            580                 585                 590         


Leu Val Ala Asp Val Asn Ala Asp Arg Asn Met Glu Ile Pro Lys Gly 
        595                 600                 605             


Leu Ile Arg Ser Ala Ser Val Thr Pro Lys Ile Asn Gln Leu Cys Ser 
    610                 615                 620                 


Gln Thr Lys Gly Ser Phe Val Asn Gly Val Phe Glu Val His Lys Lys 
625                 630                 635                 640 


Asn Val Arg Gly Glu Phe Thr Tyr Tyr Glu Ile Gln Asp Asn Thr Gly 
                645                 650                 655     


Lys Met Glu Val Val Val His Gly Arg Leu Thr Thr Ile Asn Cys Glu 
            660                 665                 670         


Glu Gly Asp Lys Leu Lys Leu Thr Cys Phe Glu Leu Ala Pro Lys Ser 
        675                 680                 685             


Gly Asn Thr Gly Glu Leu Arg Ser Val Ile His Ser His Ile Lys Val 
    690                 695                 700                 


Ile Lys Thr Arg Lys Asn Lys Lys Asp Ile Leu Asn Pro Asp Ser Ser 
705                 710                 715                 720 


Met Glu Thr Ser Pro Asp Phe Phe Phe 
                725                 


<210>  66
<211>  1569
<212>  DNA
<213>  Homo sapiens

<400>  66
atgcagcctt ggcacggaaa ggccatgcag agagcttccg aggccggagc cactgccccc       60

aaggcttccg cacggaatgc caggggcgcc ccgatggatc ccaccgagtc tccggctgcc      120

cccgaggccg ccctgcctaa ggcgggaaag ttcggccccg ccaggaagtc gggatcccgg      180

cagaaaaaga gcgccccgga cacccaggag aggccgcccg tccgcgcaac tggggcccgc      240

gccaaaaagg cccctcagcg cgcccaggac acgcagccgt ctgacgccac cagcgcccct      300

ggggcagagg ggctggagcc tcctgcggct cgggagccgg ctctttccag ggctggttct      360

tgccgccaga ggggcgcgcg ctgctccacg aagccaagac ctccgcccgg gccctgggac      420

gtgcccagcc ccggcctgcc ggtctcggcc cccattctcg tacggaggga tgcggcgcct      480

ggggcctcga agctccgggc ggttttggag aagttgaagc tcagccgcga tgatatctcc      540

acggcggcgg ggatggtgaa aggggttgtg gaccacctgc tgctcagact gaagtgcgac      600

tccgcgttca gaggcgtcgg gctgctgaac accgggagct actatgagca cgtgaagatt      660

tctgcaccta atgaatttga tgtcatgttt aaactggaag tccccagaat tcaactagaa      720

gaatattcca acactcgtgc atattacttt gtgaaattta aaagaaatcc gaaagaaaat      780

cctctgagtc agtttttaga aggtgaaata ttatcagctt ctaagatgct gtcaaagttt      840

aggaaaatca ttaaggaaga aattaacgac attaaagata cagatgtcat catgaagagg      900

aaaagaggag ggagccctgc tgtaacactt cttattagtg aaaaaatatc tgtggatata      960

accctggctt tggaatcaaa aagtagctgg cctgctagca cccaagaagg cctgcgcatt     1020

caaaactggc tttcagcaaa agttaggaag caactacgac taaagccatt ttaccttgta     1080

cccaagcatg caaaggaagg aaatggtttc caagaagaaa catggcggct atccttctct     1140

cacatcgaaa aggaaatttt gaacaatcat ggaaaatcta aaacgtgctg tgaaaacaaa     1200

gaagagaaat gttgcaggaa agattgttta aaactaatga aatacctttt agaacagctg     1260

aaagaaaggt ttaaagacaa aaaacatctg gataaattct cttcttatca tgtgaaaact     1320

gccttctttc acgtatgtac ccagaaccct caagacagtc agtgggaccg caaagacctg     1380

ggcctctgct ttgataactg cgtgacatac tttcttcagt gcctcaggac agaaaaactt     1440

gagaattatt ttattcctga attcaatcta ttctctagca acttaattga caaaagaagt     1500

aaggaatttc tgacaaagca aattgaatat gaaagaaaca atgagtttcc agtttttgat     1560

gaattttga                                                             1569


<210>  67
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Gln Pro Trp His Gly Lys Ala Met Gln Arg Ala Ser Glu Ala Gly 
1               5                   10                  15      


Ala Thr Ala Pro Lys Ala Ser Ala Arg Asn Ala Arg Gly Ala Pro Met 
            20                  25                  30          


Asp Pro Thr Glu Ser Pro Ala Ala Pro Glu Ala Ala Leu Pro Lys Ala 
        35                  40                  45              


Gly Lys Phe Gly Pro Ala Arg Lys Ser Gly Ser Arg Gln Lys Lys Ser 
    50                  55                  60                  


Ala Pro Asp Thr Gln Glu Arg Pro Pro Val Arg Ala Thr Gly Ala Arg 
65                  70                  75                  80  


Ala Lys Lys Ala Pro Gln Arg Ala Gln Asp Thr Gln Pro Ser Asp Ala 
                85                  90                  95      


Thr Ser Ala Pro Gly Ala Glu Gly Leu Glu Pro Pro Ala Ala Arg Glu 
            100                 105                 110         


Pro Ala Leu Ser Arg Ala Gly Ser Cys Arg Gln Arg Gly Ala Arg Cys 
        115                 120                 125             


Ser Thr Lys Pro Arg Pro Pro Pro Gly Pro Trp Asp Val Pro Ser Pro 
    130                 135                 140                 


Gly Leu Pro Val Ser Ala Pro Ile Leu Val Arg Arg Asp Ala Ala Pro 
145                 150                 155                 160 


Gly Ala Ser Lys Leu Arg Ala Val Leu Glu Lys Leu Lys Leu Ser Arg 
                165                 170                 175     


Asp Asp Ile Ser Thr Ala Ala Gly Met Val Lys Gly Val Val Asp His 
            180                 185                 190         


Leu Leu Leu Arg Leu Lys Cys Asp Ser Ala Phe Arg Gly Val Gly Leu 
        195                 200                 205             


Leu Asn Thr Gly Ser Tyr Tyr Glu His Val Lys Ile Ser Ala Pro Asn 
    210                 215                 220                 


Glu Phe Asp Val Met Phe Lys Leu Glu Val Pro Arg Ile Gln Leu Glu 
225                 230                 235                 240 


Glu Tyr Ser Asn Thr Arg Ala Tyr Tyr Phe Val Lys Phe Lys Arg Asn 
                245                 250                 255     


Pro Lys Glu Asn Pro Leu Ser Gln Phe Leu Glu Gly Glu Ile Leu Ser 
            260                 265                 270         


Ala Ser Lys Met Leu Ser Lys Phe Arg Lys Ile Ile Lys Glu Glu Ile 
        275                 280                 285             


Asn Asp Ile Lys Asp Thr Asp Val Ile Met Lys Arg Lys Arg Gly Gly 
    290                 295                 300                 


Ser Pro Ala Val Thr Leu Leu Ile Ser Glu Lys Ile Ser Val Asp Ile 
305                 310                 315                 320 


Thr Leu Ala Leu Glu Ser Lys Ser Ser Trp Pro Ala Ser Thr Gln Glu 
                325                 330                 335     


Gly Leu Arg Ile Gln Asn Trp Leu Ser Ala Lys Val Arg Lys Gln Leu 
            340                 345                 350         


Arg Leu Lys Pro Phe Tyr Leu Val Pro Lys His Ala Lys Glu Gly Asn 
        355                 360                 365             


Gly Phe Gln Glu Glu Thr Trp Arg Leu Ser Phe Ser His Ile Glu Lys 
    370                 375                 380                 


Glu Ile Leu Asn Asn His Gly Lys Ser Lys Thr Cys Cys Glu Asn Lys 
385                 390                 395                 400 


Glu Glu Lys Cys Cys Arg Lys Asp Cys Leu Lys Leu Met Lys Tyr Leu 
                405                 410                 415     


Leu Glu Gln Leu Lys Glu Arg Phe Lys Asp Lys Lys His Leu Asp Lys 
            420                 425                 430         


Phe Ser Ser Tyr His Val Lys Thr Ala Phe Phe His Val Cys Thr Gln 
        435                 440                 445             


Asn Pro Gln Asp Ser Gln Trp Asp Arg Lys Asp Leu Gly Leu Cys Phe 
    450                 455                 460                 


Asp Asn Cys Val Thr Tyr Phe Leu Gln Cys Leu Arg Thr Glu Lys Leu 
465                 470                 475                 480 


Glu Asn Tyr Phe Ile Pro Glu Phe Asn Leu Phe Ser Ser Asn Leu Ile 
                485                 490                 495     


Asp Lys Arg Ser Lys Glu Phe Leu Thr Lys Gln Ile Glu Tyr Glu Arg 
            500                 505                 510         


Asn Asn Glu Phe Pro Val Phe Asp Glu Phe 
        515                 520         


<210>  68
<211>  1869
<212>  DNA
<213>  Homo sapiens

<400>  68
atggaggagt cggaacccga acggaagcgg gctcgcaccg acgaggtgcc tgccggagga       60

agccgctccg aggcggaaga tgaggacgac gaggactacg tgccctatgt gccgttacgg      120

cagcgccggc agctactgct ccagaagctg ctgcagcgaa gacgcaaggg agctgcggag      180

gaagagcagc aggacagcgg tagtgaaccc cggggagatg aggacgacat cccgctaggc      240

cctcagtcca acgtcagcct cctggatcag caccagcacc ttaaagagaa ggctgaagcg      300

cgcaaagagt ctgccaagga gaagcagctg aaggaagaag agaagatcct ggagagtgtt      360

gccgagggcc gagcattgat gtcagtgaag gagatggcta agggcattac gtatgatgac      420

cccatcaaaa ccagctggac tccaccccgt tatgttctga gcatgtctga agagcgacat      480

gagcgcgtgc ggaagaaata ccacatcctg gtggagggag acggtatccc accacccatc      540

aagagcttca aggaaatgaa gtttcctgca gccatcctga gaggcctgaa gaagaaaggc      600

attcaccacc caacacccat tcagatccag ggcatcccca ccattctatc tggccgtgac      660

atgataggca tcgctttcac gggttcaggc aagacactgg tgttcacgtt gcccgtcatc      720

atgttctgcc tggaacaaga gaagaggtta cccttctcaa agcgcgaggg gccctatgga      780

ctcatcatct gcccctcgcg ggagctggcc cggcagaccc atggcatcct ggagtactac      840

tgccgcctgc tgcaggagga cagctcacca ctcctgcgct gcgccctctg cattgggggc      900

atgtccgtga aagagcagat ggagaccatc cgacacggtg tacacatgat ggtggccacc      960

ccggggcgcc tcatggattt gctgcagaag aagatggtca gcctagacat ctgtcgctac     1020

ctggccctgg acgaggctga ccgcatgatc gacatgggct tcgagggtga catccgtacc     1080

atcttctcct acttcaaggg ccagcgacag accctgctct tcagtgccac catgccgaag     1140

aagattcaga actttgctaa gagtgccctt gtaaagcctg tgaccatcaa tgtggggcgc     1200

gctggggctg ccagcctgga tgtcatccag gaggtagaat atgtgaagga ggaggccaag     1260

atggtgtacc tgctcgagtg cctgcagaag acacccccgc ctgtactcat ctttgcagag     1320

aagaaggcag acgtggacgc catccacgag tacctgctgc tcaagggggt tgaggccgta     1380

gccatccatg ggggcaaaga ccaggaggaa cggactaagg ccatcgaggc attccgggag     1440

ggcaagaagg atgtcctagt agccacagac gttgcctcca agggcctgga cttccctgcc     1500

atccagcacg tcatcaatta tgacatgcca gaggagattg agaactatgt acaccggatt     1560

ggccgcaccg ggcgctcggg aaacacaggc atcgccacta ccttcatcaa caaagcgtgt     1620

gatgagtcag tgctgatgga cctcaaagcg ctgctgctag aagccaagca gaaggtgccg     1680

cccgtgctgc aggtgctgca ttgcggggat gagtccatgc tggacattgg aggagagcgc     1740

ggctgtgcct tctgcggggg cctgggtcat cggatcactg actgccccaa actcgaggct     1800

atgcagacca agcaggtcag caacatcggt cgcaaggact acctggccca cagctccatg     1860

gacttctga                                                             1869


<210>  69
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Glu Glu Ser Glu Pro Glu Arg Lys Arg Ala Arg Thr Asp Glu Val 
1               5                   10                  15      


Pro Ala Gly Gly Ser Arg Ser Glu Ala Glu Asp Glu Asp Asp Glu Asp 
            20                  25                  30          


Tyr Val Pro Tyr Val Pro Leu Arg Gln Arg Arg Gln Leu Leu Leu Gln 
        35                  40                  45              


Lys Leu Leu Gln Arg Arg Arg Lys Gly Ala Ala Glu Glu Glu Gln Gln 
    50                  55                  60                  


Asp Ser Gly Ser Glu Pro Arg Gly Asp Glu Asp Asp Ile Pro Leu Gly 
65                  70                  75                  80  


Pro Gln Ser Asn Val Ser Leu Leu Asp Gln His Gln His Leu Lys Glu 
                85                  90                  95      


Lys Ala Glu Ala Arg Lys Glu Ser Ala Lys Glu Lys Gln Leu Lys Glu 
            100                 105                 110         


Glu Glu Lys Ile Leu Glu Ser Val Ala Glu Gly Arg Ala Leu Met Ser 
        115                 120                 125             


Val Lys Glu Met Ala Lys Gly Ile Thr Tyr Asp Asp Pro Ile Lys Thr 
    130                 135                 140                 


Ser Trp Thr Pro Pro Arg Tyr Val Leu Ser Met Ser Glu Glu Arg His 
145                 150                 155                 160 


Glu Arg Val Arg Lys Lys Tyr His Ile Leu Val Glu Gly Asp Gly Ile 
                165                 170                 175     


Pro Pro Pro Ile Lys Ser Phe Lys Glu Met Lys Phe Pro Ala Ala Ile 
            180                 185                 190         


Leu Arg Gly Leu Lys Lys Lys Gly Ile His His Pro Thr Pro Ile Gln 
        195                 200                 205             


Ile Gln Gly Ile Pro Thr Ile Leu Ser Gly Arg Asp Met Ile Gly Ile 
    210                 215                 220                 


Ala Phe Thr Gly Ser Gly Lys Thr Leu Val Phe Thr Leu Pro Val Ile 
225                 230                 235                 240 


Met Phe Cys Leu Glu Gln Glu Lys Arg Leu Pro Phe Ser Lys Arg Glu 
                245                 250                 255     


Gly Pro Tyr Gly Leu Ile Ile Cys Pro Ser Arg Glu Leu Ala Arg Gln 
            260                 265                 270         


Thr His Gly Ile Leu Glu Tyr Tyr Cys Arg Leu Leu Gln Glu Asp Ser 
        275                 280                 285             


Ser Pro Leu Leu Arg Cys Ala Leu Cys Ile Gly Gly Met Ser Val Lys 
    290                 295                 300                 


Glu Gln Met Glu Thr Ile Arg His Gly Val His Met Met Val Ala Thr 
305                 310                 315                 320 


Pro Gly Arg Leu Met Asp Leu Leu Gln Lys Lys Met Val Ser Leu Asp 
                325                 330                 335     


Ile Cys Arg Tyr Leu Ala Leu Asp Glu Ala Asp Arg Met Ile Asp Met 
            340                 345                 350         


Gly Phe Glu Gly Asp Ile Arg Thr Ile Phe Ser Tyr Phe Lys Gly Gln 
        355                 360                 365             


Arg Gln Thr Leu Leu Phe Ser Ala Thr Met Pro Lys Lys Ile Gln Asn 
    370                 375                 380                 


Phe Ala Lys Ser Ala Leu Val Lys Pro Val Thr Ile Asn Val Gly Arg 
385                 390                 395                 400 


Ala Gly Ala Ala Ser Leu Asp Val Ile Gln Glu Val Glu Tyr Val Lys 
                405                 410                 415     


Glu Glu Ala Lys Met Val Tyr Leu Leu Glu Cys Leu Gln Lys Thr Pro 
            420                 425                 430         


Pro Pro Val Leu Ile Phe Ala Glu Lys Lys Ala Asp Val Asp Ala Ile 
        435                 440                 445             


His Glu Tyr Leu Leu Leu Lys Gly Val Glu Ala Val Ala Ile His Gly 
    450                 455                 460                 


Gly Lys Asp Gln Glu Glu Arg Thr Lys Ala Ile Glu Ala Phe Arg Glu 
465                 470                 475                 480 


Gly Lys Lys Asp Val Leu Val Ala Thr Asp Val Ala Ser Lys Gly Leu 
                485                 490                 495     


Asp Phe Pro Ala Ile Gln His Val Ile Asn Tyr Asp Met Pro Glu Glu 
            500                 505                 510         


Ile Glu Asn Tyr Val His Arg Ile Gly Arg Thr Gly Arg Ser Gly Asn 
        515                 520                 525             


Thr Gly Ile Ala Thr Thr Phe Ile Asn Lys Ala Cys Asp Glu Ser Val 
    530                 535                 540                 


Leu Met Asp Leu Lys Ala Leu Leu Leu Glu Ala Lys Gln Lys Val Pro 
545                 550                 555                 560 


Pro Val Leu Gln Val Leu His Cys Gly Asp Glu Ser Met Leu Asp Ile 
                565                 570                 575     


Gly Gly Glu Arg Gly Cys Ala Phe Cys Gly Gly Leu Gly His Arg Ile 
            580                 585                 590         


Thr Asp Cys Pro Lys Leu Glu Ala Met Gln Thr Lys Gln Val Ser Asn 
        595                 600                 605             


Ile Gly Arg Lys Asp Tyr Leu Ala His Ser Ser Met Asp Phe 
    610                 615                 620         


<210>  70
<211>  1491
<212>  DNA
<213>  Homo sapiens

<400>  70
atgtcagtga aggagatggc taagggcatt acgtatgatg accccatcaa aaccagctgg       60

actccacccc gttatgttct gagcatgtct gaagagcgac atgagcgcgt gcggaagaaa      120

taccacatcc tggtggaggg agacggtatc ccaccaccca tcaagagctt caaggaaatg      180

aagtttcctg cagccatcct gagaggcctg aagaagaaag gcattcacca cccaacaccc      240

attcagatcc agggcatccc caccattcta tctggccgtg acatgatagg catcgctttc      300

acgggttcag gcaagacact ggtgttcacg ttgcccgtca tcatgttctg cctggaacaa      360

gagaagaggt tacccttctc aaagcgcgag gggccctatg gactcatcat ctgcccctcg      420

cgggagctgg cccggcagac ccatggcatc ctggagtact actgccgcct gctgcaggag      480

gacagctcac cactcctgcg ctgcgccctc tgcattgggg gcatgtccgt gaaagagcag      540

atggagacca tccgacacgg tgtacacatg atggtggcca ccccggggcg cctcatggat      600

ttgctgcaga agaagatggt cagcctagac atctgtcgct acctggccct ggacgaggct      660

gaccgcatga tcgacatggg cttcgagggt gacatccgta ccatcttctc ctacttcaag      720

ggccagcgac agaccctgct cttcagtgcc accatgccga agaagattca gaactttgct      780

aagagtgccc ttgtaaagcc tgtgaccatc aatgtggggc gcgctggggc tgccagcctg      840

gatgtcatcc aggaggtaga atatgtgaag gaggaggcca agatggtgta cctgctcgag      900

tgcctgcaga agacaccccc gcctgtactc atctttgcag agaagaaggc agacgtggac      960

gccatccacg agtacctgct gctcaagggg gttgaggccg tagccatcca tgggggcaaa     1020

gaccaggagg aacggactaa ggccatcgag gcattccggg agggcaagaa ggatgtccta     1080

gtagccacag acgttgcctc caagggcctg gacttccctg ccatccagca cgtcatcaat     1140

tatgacatgc cagaggagat tgagaactat gtacaccgga ttggccgcac cgggcgctcg     1200

ggaaacacag gcatcgccac taccttcatc aacaaagcgt gtgatgagtc agtgctgatg     1260

gacctcaaag cgctgctgct agaagccaag cagaaggtgc cgcccgtgct gcaggtgctg     1320

cattgcgggg atgagtccat gctggacatt ggaggagagc gcggctgtgc cttctgcggg     1380

ggcctgggtc atcggatcac tgactgcccc aaactcgagg ctatgcagac caagcaggtc     1440

agcaacatcg gtcgcaagga ctacctggcc cacagctcca tggacttctg a              1491


<210>  71
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ser Val Lys Glu Met Ala Lys Gly Ile Thr Tyr Asp Asp Pro Ile 
1               5                   10                  15      


Lys Thr Ser Trp Thr Pro Pro Arg Tyr Val Leu Ser Met Ser Glu Glu 
            20                  25                  30          


Arg His Glu Arg Val Arg Lys Lys Tyr His Ile Leu Val Glu Gly Asp 
        35                  40                  45              


Gly Ile Pro Pro Pro Ile Lys Ser Phe Lys Glu Met Lys Phe Pro Ala 
    50                  55                  60                  


Ala Ile Leu Arg Gly Leu Lys Lys Lys Gly Ile His His Pro Thr Pro 
65                  70                  75                  80  


Ile Gln Ile Gln Gly Ile Pro Thr Ile Leu Ser Gly Arg Asp Met Ile 
                85                  90                  95      


Gly Ile Ala Phe Thr Gly Ser Gly Lys Thr Leu Val Phe Thr Leu Pro 
            100                 105                 110         


Val Ile Met Phe Cys Leu Glu Gln Glu Lys Arg Leu Pro Phe Ser Lys 
        115                 120                 125             


Arg Glu Gly Pro Tyr Gly Leu Ile Ile Cys Pro Ser Arg Glu Leu Ala 
    130                 135                 140                 


Arg Gln Thr His Gly Ile Leu Glu Tyr Tyr Cys Arg Leu Leu Gln Glu 
145                 150                 155                 160 


Asp Ser Ser Pro Leu Leu Arg Cys Ala Leu Cys Ile Gly Gly Met Ser 
                165                 170                 175     


Val Lys Glu Gln Met Glu Thr Ile Arg His Gly Val His Met Met Val 
            180                 185                 190         


Ala Thr Pro Gly Arg Leu Met Asp Leu Leu Gln Lys Lys Met Val Ser 
        195                 200                 205             


Leu Asp Ile Cys Arg Tyr Leu Ala Leu Asp Glu Ala Asp Arg Met Ile 
    210                 215                 220                 


Asp Met Gly Phe Glu Gly Asp Ile Arg Thr Ile Phe Ser Tyr Phe Lys 
225                 230                 235                 240 


Gly Gln Arg Gln Thr Leu Leu Phe Ser Ala Thr Met Pro Lys Lys Ile 
                245                 250                 255     


Gln Asn Phe Ala Lys Ser Ala Leu Val Lys Pro Val Thr Ile Asn Val 
            260                 265                 270         


Gly Arg Ala Gly Ala Ala Ser Leu Asp Val Ile Gln Glu Val Glu Tyr 
        275                 280                 285             


Val Lys Glu Glu Ala Lys Met Val Tyr Leu Leu Glu Cys Leu Gln Lys 
    290                 295                 300                 


Thr Pro Pro Pro Val Leu Ile Phe Ala Glu Lys Lys Ala Asp Val Asp 
305                 310                 315                 320 


Ala Ile His Glu Tyr Leu Leu Leu Lys Gly Val Glu Ala Val Ala Ile 
                325                 330                 335     


His Gly Gly Lys Asp Gln Glu Glu Arg Thr Lys Ala Ile Glu Ala Phe 
            340                 345                 350         


Arg Glu Gly Lys Lys Asp Val Leu Val Ala Thr Asp Val Ala Ser Lys 
        355                 360                 365             


Gly Leu Asp Phe Pro Ala Ile Gln His Val Ile Asn Tyr Asp Met Pro 
    370                 375                 380                 


Glu Glu Ile Glu Asn Tyr Val His Arg Ile Gly Arg Thr Gly Arg Ser 
385                 390                 395                 400 


Gly Asn Thr Gly Ile Ala Thr Thr Phe Ile Asn Lys Ala Cys Asp Glu 
                405                 410                 415     


Ser Val Leu Met Asp Leu Lys Ala Leu Leu Leu Glu Ala Lys Gln Lys 
            420                 425                 430         


Val Pro Pro Val Leu Gln Val Leu His Cys Gly Asp Glu Ser Met Leu 
        435                 440                 445             


Asp Ile Gly Gly Glu Arg Gly Cys Ala Phe Cys Gly Gly Leu Gly His 
    450                 455                 460                 


Arg Ile Thr Asp Cys Pro Lys Leu Glu Ala Met Gln Thr Lys Gln Val 
465                 470                 475                 480 


Ser Asn Ile Gly Arg Lys Asp Tyr Leu Ala His Ser Ser Met Asp Phe 
                485                 490                 495     


<210>  72
<211>  2541
<212>  DNA
<213>  Homo sapiens

<400>  72
atggggatac agggattgct acaatttatc aaagaagctt cagaacccat ccatgtgagg       60

aagtataaag ggcaggtagt agctgtggat acatattgct ggcttcacaa aggagctatt      120

gcttgtgctg aaaaactagc caaaggtgaa cctactgata ggtatgtagg attttgtatg      180

aaatttgtaa atatgttact atctcatggg atcaagccta ttctcgtatt tgatggatgt      240

actttacctt ctaaaaagga agtagagaga tctagaagag aaagacgaca agccaatctt      300

cttaagggaa agcaacttct tcgtgagggg aaagtctcgg aagctcgaga gtgtttcacc      360

cggtctatca atatcacaca tgccatggcc cacaaagtaa ttaaagctgc ccggtctcag      420

ggggtagatt gcctcgtggc tccctatgaa gctgatgcgc agttggccta tcttaacaaa      480

gcgggaattg tgcaagccat aattacagag gactcggatc tcctagcttt tggctgtaaa      540

aaggtaattt taaagatgga ccagtttgga aatggacttg aaattgatca agctcggcta      600

ggaatgtgca gacagcttgg ggatgtattc acggaagaga agtttcgtta catgtgtatt      660

ctttcaggtt gtgactacct gtcatcactg cgtgggattg gattagcaaa ggcatgcaaa      720

gtcctaagac tagccaataa tccagatata gtaaaggtta tcaagaaaat tggacattat      780

ctcaagatga atatcacggt accagaggat tacatcaacg ggtttattcg ggccaacaat      840

accttcctct atcagctagt ttttgatccc atcaaaagga aacttattcc tctgaacgcc      900

tatgaagatg atgttgatcc tgaaacacta agctacgctg ggcaatatgt tgatgattcc      960

atagctcttc aaatagcact tggaaataaa gatataaata cttttgaaca gatcgatgac     1020

tacaatccag acactgctat gcctgcccat tcaagaagtc atagttggga tgacaaaaca     1080

tgtcaaaagt cagctaatgt tagcagcatt tggcatagga attactctcc cagaccagag     1140

tcgggtactg tttcagatgc cccacaattg aaggaaaatc caagtactgt gggagtggaa     1200

cgagtgatta gtactaaagg gttaaatctc ccaaggaaat catccattgt gaaaagacca     1260

agaagtgcag agctgtcaga agatgacctg ttgagtcagt attctctttc atttacgaag     1320

aagaccaaga aaaatagctc tgaaggcaat aaatcattga gcttttctga agtgtttgtg     1380

cctgacctgg taaatggacc tactaacaaa aagagtgtaa gcactccacc taggacgaga     1440

aataaatttg caacattttt acaaaggaaa aatgaagaaa gtggtgcagt tgtggttcca     1500

gggaccagaa gcaggttttt ttgcagttca gattctactg actgtgtatc aaacaaagtg     1560

agcatccagc ctctggatga aactgctgtc acagataaag agaacaatct gcatgaatca     1620

gagtatggag accaagaagg caagagactg gttgacacag atgtagcacg taattcaagt     1680

gatgacattc cgaataatca tattccaggt gatcatattc cagacaaggc aacagtgttt     1740

acagatgaag agtcctactc ttttgagagc agcaaattta caaggaccat ttcaccaccc     1800

actttgggaa cactaagaag ttgttttagt tggtctggag gtcttggaga tttttcaaga     1860

acgccgagcc cctctccaag cacagcattg cagcagttcc gaagaaagag cgattccccc     1920

acctctttgc ctgagaataa tatgtctgat gtgtcgcagt taaagagcga ggagtccagt     1980

gacgatgagt ctcatccctt acgagaagag gcatgttctt cacagtccca ggaaagtgga     2040

gaattctcac tgcagagttc aaatgcatca aagctttctc agtgctctag taaggactct     2100

gattcagagg aatctgattg caatattaag ttacttgaca gtcaaagtga ccagacctcc     2160

aagctacgtt tatctcattt ctcaaaaaaa gacacacctc taaggaacaa ggttcctggg     2220

ctatataagt ccagttctgc agactctctt tctacaacca agatcaaacc tctaggacct     2280

gccagagcca gtgggctgag caagaagccg gcaagcatcc agaagagaaa gcatcataat     2340

gccgagaaca agccggggtt acagatcaaa ctcaatgagc tctggaaaaa ctttggattt     2400

aaaaaagatt ctgaaaagct tcctccttgt aagaaacccc tgtccccagt cagagataac     2460

atccaactaa ctccagaagc ggaagaggat atatttaaca aacctgaatg tggccgtgtt     2520

caaagagcaa tattccagta a                                               2541


<210>  73
<211>  846
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 
            420                 425                 430         


Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 
        435                 440                 445             


Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 
    450                 455                 460                 


Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 
465                 470                 475                 480 


Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 
                485                 490                 495     


Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 
            500                 505                 510         


Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 
        515                 520                 525             


Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 
    530                 535                 540                 


Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 
545                 550                 555                 560 


Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 
                565                 570                 575     


Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 
            580                 585                 590         


Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 
        595                 600                 605             


Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 
    610                 615                 620                 


Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 
625                 630                 635                 640 


Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 
                645                 650                 655     


Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys 
            660                 665                 670         


Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 
        675                 680                 685             


Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 
    690                 695                 700                 


Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 
                725                 730                 735     


Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 
            740                 745                 750         


Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 
        755                 760                 765             


Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 
    770                 775                 780                 


Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 
785                 790                 795                 800 


Lys Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro 
                805                 810                 815     


Val Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe 
            820                 825                 830         


Asn Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 
        835                 840                 845     


<210>  74
<211>  2538
<212>  DNA
<213>  Homo sapiens

<400>  74
atggggatac agggattgct acaatttatc aaagaagctt cagaacccat ccatgtgagg       60

aagtataaag ggcaggtagt agctgtggat acatattgct ggcttcacaa aggagctatt      120

gcttgtgctg aaaaactagc caaaggtgaa cctactgata ggtatgtagg attttgtatg      180

aaatttgtaa atatgttact atctcatggg atcaagccta ttctcgtatt tgatggatgt      240

actttacctt ctaaaaagga agtagagaga tctagaagag aaagacgaca agccaatctt      300

cttaagggaa agcaacttct tcgtgagggg aaagtctcgg aagctcgaga gtgtttcacc      360

cggtctatca atatcacaca tgccatggcc cacaaagtaa ttaaagctgc ccggtctcag      420

ggggtagatt gcctcgtggc tccctatgaa gctgatgcgc agttggccta tcttaacaaa      480

gcgggaattg tgcaagccat aattacagag gactcggatc tcctagcttt tggctgtaaa      540

aaggtaattt taaagatgga ccagtttgga aatggacttg aaattgatca agctcggcta      600

ggaatgtgca gacagcttgg ggatgtattc acggaagaga agtttcgtta catgtgtatt      660

ctttcaggtt gtgactacct gtcatcactg cgtgggattg gattagcaaa ggcatgcaaa      720

gtcctaagac tagccaataa tccagatata gtaaaggtta tcaagaaaat tggacattat      780

ctcaagatga atatcacggt accagaggat tacatcaacg ggtttattcg ggccaacaat      840

accttcctct atcagctagt ttttgatccc atcaaaagga aacttattcc tctgaacgcc      900

tatgaagatg atgttgatcc tgaaacacta agctacgctg ggcaatatgt tgatgattcc      960

atagctcttc aaatagcact tggaaataaa gatataaata cttttgaaca gatcgatgac     1020

tacaatccag acactgctat gcctgcccat tcaagaagtc atagttggga tgacaaaaca     1080

tgtcaaaagt cagctaatgt tagcagcatt tggcatagga attactctcc cagaccagag     1140

tcgggtactg tttcagatgc cccacaattg aaggaaaatc caagtactgt gggagtggaa     1200

cgagtgatta gtactaaagg gttaaatctc ccaaggaaat catccattgt gaaaagacca     1260

agaagtgagc tgtcagaaga tgacctgttg agtcagtatt ctctttcatt tacgaagaag     1320

accaagaaaa atagctctga aggcaataaa tcattgagct tttctgaagt gtttgtgcct     1380

gacctggtaa atggacctac taacaaaaag agtgtaagca ctccacctag gacgagaaat     1440

aaatttgcaa catttttaca aaggaaaaat gaagaaagtg gtgcagttgt ggttccaggg     1500

accagaagca ggtttttttg cagttcagat tctactgact gtgtatcaaa caaagtgagc     1560

atccagcctc tggatgaaac tgctgtcaca gataaagaga acaatctgca tgaatcagag     1620

tatggagacc aagaaggcaa gagactggtt gacacagatg tagcacgtaa ttcaagtgat     1680

gacattccga ataatcatat tccaggtgat catattccag acaaggcaac agtgtttaca     1740

gatgaagagt cctactcttt tgagagcagc aaatttacaa ggaccatttc accacccact     1800

ttgggaacac taagaagttg ttttagttgg tctggaggtc ttggagattt ttcaagaacg     1860

ccgagcccct ctccaagcac agcattgcag cagttccgaa gaaagagcga ttcccccacc     1920

tctttgcctg agaataatat gtctgatgtg tcgcagttaa agagcgagga gtccagtgac     1980

gatgagtctc atcccttacg agaagaggca tgttcttcac agtcccagga aagtggagaa     2040

ttctcactgc agagttcaaa tgcatcaaag ctttctcagt gctctagtaa ggactctgat     2100

tcagaggaat ctgattgcaa tattaagtta cttgacagtc aaagtgacca gacctccaag     2160

ctacgtttat ctcatttctc aaaaaaagac acacctctaa ggaacaaggt tcctgggcta     2220

tataagtcca gttctgcaga ctctctttct acaaccaaga tcaaacctct aggacctgcc     2280

agagccagtg ggctgagcaa gaagccggca agcatccaga agagaaagca tcataatgcc     2340

gagaacaagc cggggttaca gatcaaactc aatgagctct ggaaaaactt tggatttaaa     2400

aaagattctg aaaagcttcc tccttgtaag aaacccctgt ccccagtcag agataacatc     2460

caactaactc cagaagcgga agaggatata tttaacaaac ctgaatgtgg ccgtgttcaa     2520

agagcaatat tccagtaa                                                   2538


<210>  75
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Glu Leu Ser Glu Asp Asp Leu Leu Ser Gln 
            420                 425                 430         


Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu Gly 
        435                 440                 445             


Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val Asn 
    450                 455                 460                 


Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg Asn 
465                 470                 475                 480 


Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala Val 
                485                 490                 495     


Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser Thr 
            500                 505                 510         


Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr Ala 
        515                 520                 525             


Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp Gln 
    530                 535                 540                 


Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser Asp 
545                 550                 555                 560 


Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys Ala 
                565                 570                 575     


Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys Phe 
            580                 585                 590         


Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys Phe 
        595                 600                 605             


Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro Ser 
    610                 615                 620                 


Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro Thr 
625                 630                 635                 640 


Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser Glu 
                645                 650                 655     


Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys Ser 
            660                 665                 670         


Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn Ala 
        675                 680                 685             


Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu Ser 
    690                 695                 700                 


Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser Lys 
705                 710                 715                 720 


Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn Lys 
                725                 730                 735     


Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr Thr 
            740                 745                 750         


Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys Lys 
        755                 760                 765             


Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys Pro 
    770                 775                 780                 


Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe Lys 
785                 790                 795                 800 


Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro Val 
                805                 810                 815     


Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe Asn 
            820                 825                 830         


Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 
        835                 840                 845 


<210>  76
<211>  2412
<212>  DNA
<213>  Homo sapiens

<400>  76
atggggatac agggattgct acaatttatc aaagaagctt cagaacccat ccatgtgagg       60

aagtataaag ggcaggtagt agctgtggat acatattgct ggcttcacaa aggagctatt      120

gcttgtgctg aaaaactagc caaaggtgaa cctactgata ggtatgtagg attttgtatg      180

aaatttgtaa atatgttact atctcatggg atcaagccta ttctcgtatt tgatggatgt      240

actttacctt ctaaaaagga agtagagaga tctagaagag aaagacgaca agccaatctt      300

cttaagggaa agcaacttct tcgtgagggg aaagtctcgg aagctcgaga gtgtttcacc      360

cggtctatca atatcacaca tgccatggcc cacaaagtaa ttaaagctgc ccggtctcag      420

ggggtagatt gcctcgtggc tccctatgaa gctgatgcgc agttggccta tcttaacaaa      480

gcgggaattg tgcaagccat aattacagag gactcggatc tcctagcttt tggctgtaaa      540

aaggtaattt taaagatgga ccagtttgga aatggacttg aaattgatca agctcggcta      600

ggaatgtgca gacagcttgg ggatgtattc acggaagaga agtttcgtta catgtgtatt      660

ctttcaggtt gtgactacct gtcatcactg cgtgggattg gattagcaaa ggcatgcaaa      720

gtcctaagac tagccaataa tccagatata gtaaaggtta tcaagaaaat tggacattat      780

ctcaagatga atatcacggt accagaggat tacatcaacg ggtttattcg ggccaacaat      840

accttcctct atcagctagt ttttgatccc atcaaaagga aacttattcc tctgaacgcc      900

tatgaagatg atgttgatcc tgaaacacta agctacgctg ggcaatatgt tgatgattcc      960

atagctcttc aaatagcact tggaaataaa gatataaata cttttgaaca gatcgatgac     1020

tacaatccag acactgctat gcctgcccat tcaagaagtc atagttggga tgacaaaaca     1080

tgtcaaaagt cagctaatgt tagcagcatt tggcatagga attactctcc cagaccagag     1140

tcgggtactg tttcagatgc cccacaattg aaggaaaatc caagtactgt gggagtggaa     1200

cgagtgatta gtactaaagg gttaaatctc ccaaggaaat catccattgt gaaaagacca     1260

agaagtgcag agctgtcaga agatgacctg ttgagtcagt attctctttc atttacgaag     1320

aagaccaaga aaaatagctc tgaaggcaat aaatcattga gcttttctga agtgtttgtg     1380

cctgacctgg taaatggacc tactaacaaa aagagtgtaa gcactccacc taggacgaga     1440

aataaatttg caacattttt acaaaggaaa aatgaagaaa gtggtgcagt tgtggttcca     1500

gggaccagaa gcaggttttt ttgcagttca gattctactg actgtgtatc aaacaaagtg     1560

agcatccagc ctctggatga aactgctgtc acagataaag agaacaatct gcatgaatca     1620

gagtatggag accaagaagg caagagactg gttgacacag atgtagcacg taattcaagt     1680

gatgacattc cgaataatca tattccaggt gatcatattc cagacaaggc aacagtgttt     1740

acagatgaag agtcctactc ttttgagagc agcaaattta caaggaccat ttcaccaccc     1800

actttgggaa cactaagaag ttgttttagt tggtctggag gtcttggaga tttttcaaga     1860

acgccgagcc cctctccaag cacagcattg cagcagttcc gaagaaagag cgattccccc     1920

acctctttgc ctgagaataa tatgtctgat gtgtcgcagt taaagagcga ggagtccagt     1980

gacgatgagt ctcatccctt acgagaagag gcatgttctt cacagtccca ggaaagtgga     2040

gaattctcac tgcagagttc aaatgcatca aagctttctc agtgctctag taaggactct     2100

gattcagagg aatctgattg caatattaag ttacttgaca gtcaaagtga ccagacctcc     2160

aagctacgtt tatctcattt ctcaaaaaaa gacacacctc taaggaacaa ggttcctggg     2220

ctatataagt ccagttctgc agactctctt tctacaacca agatcaaacc tctaggacct     2280

gccagagcca gtgggctgag caagaagccg gcaagcatcc agaagagaaa gcatcataat     2340

gccgagaaca agccggggtt acagatcaaa ctcaatgagc tctggaaaaa ctttggattt     2400

aaaaaattct ga                                                         2412


<210>  77
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 
            420                 425                 430         


Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 
        435                 440                 445             


Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 
    450                 455                 460                 


Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 
465                 470                 475                 480 


Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 
                485                 490                 495     


Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 
            500                 505                 510         


Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 
        515                 520                 525             


Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 
    530                 535                 540                 


Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 
545                 550                 555                 560 


Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 
                565                 570                 575     


Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 
            580                 585                 590         


Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 
        595                 600                 605             


Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 
    610                 615                 620                 


Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 
625                 630                 635                 640 


Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 
                645                 650                 655     


Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys 
            660                 665                 670         


Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 
        675                 680                 685             


Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 
    690                 695                 700                 


Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 
                725                 730                 735     


Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 
            740                 745                 750         


Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 
        755                 760                 765             


Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 
    770                 775                 780                 


Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 
785                 790                 795                 800 


Lys Lys Phe 
            


<210>  78
<211>  3183
<212>  DNA
<213>  Homo sapiens

<400>  78
atggagcagc tgaacgaact ggagctgctg atggagaaga gtttttggga ggaggcggag       60

ctgccggcgg agctatttca gaagaaagtg gtagcttcct ttccaagaac agttctgagc      120

acaggaatgg ataaccggta cctggtgttg gcagtcaata ctgtacagaa caaagaggga      180

aactgtgaaa agcgcctggt catcactgct tcacagtcac tagaaaataa agaactatgc      240

atccttagga atgactggtg ttctgttcca gtagagccag gagatatcat tcatttggag      300

ggagactgca catctgacac ttggataata gataaagatt ttggatattt gattctgtat      360

ccagacatgc tgatttctgg caccagcata gccagtagta ttcgatgtat gagaagagct      420

gtcctgagtg aaacttttag gagctctgat ccagccacac gccaaatgct aattggtacg      480

gttctccatg aggtgtttca aaaagccata aataatagct ttgccccaga aaagctacaa      540

gaacttgctt ttcaaacaat tcaagaaata agacatttga aggaaatgta ccgcttaaat      600

ctaagtcaag atgaaataaa acaagaagta gaggactatc ttccttcgtt ttgtaaatgg      660

gcaggagatt tcatgcataa aaacacttcg actgacttcc ctcagatgca gctctctctg      720

ccaagtgata atagtaagga taattcaaca tgtaacattg aagtcgtgaa accaatggat      780

attgaagaaa gcatttggtc ccctaggttt ggattgaaag gcaaaataga tgttacagtt      840

ggtgtgaaaa tacatcgagg gtataaaaca aaatacaaga taatgccgct ggaacttaaa      900

actggcaaag aatcaaattc tattgaacac cgtagtcagg ttgttctgta cactctacta      960

agccaagaga gaagagctga tccagaggct ggcttgcttc tctacctcaa gactggtcag     1020

atgtaccctg tgcctgccaa ccatctagat aaaagagaat tattaaagct aagaaaccag     1080

atggcattct cattgtttca ccgtattagc aaatctgcta ctagacagaa gacacagctt     1140

gcttctttgc cacaaataat tgaggaagag aaaacttgta aatattgttc acaaattggc     1200

aattgtgctc tttatagcag agcagttgaa caacagatgg attgtagttc agtcccaatt     1260

gtgatgctgc ccaaaataga agaagaaacc cagcatctga agcaaacaca cttagaatat     1320

ttcagccttt ggtgtctaat gttaaccctg gagtcacaat cgaaggataa taaaaagaat     1380

caccaaaata tctggctaat gcctgcttcg gaaatggaga agagtggcag ttgcattgga     1440

aacctgatta gaatggaaca tgtaaagata gtttgtgatg ggcaatattt acataatttc     1500

caatgtaaac atggtgccat acctgtcaca aatctaatgg caggtgacag agttattgta     1560

agtggagaag aaaggtcact gtttgctttg tctagaggat atgtgaagga gattaacatg     1620

acaacagtaa cttgtttatt agacagaaac ttgtcggtcc ttccagaatc aactttgttc     1680

agattagacc aagaagaaaa aaattgtgat atagataccc cattaggaaa tctttccaaa     1740

ttgatggaaa acacgtttgt cagcaaaaaa cttcgagatt taattattga ctttcgtgaa     1800

cctcagttta tatcctacct tagttctgtt cttccacatg atgcaaagga tacagttgcc     1860

tgcattctaa agggtttgaa taagcctcag aggcaagcga tgaaaaaggt acttctttca     1920

aaagactaca cactcatcgt gggtatgcct gggacaggaa aaacaactac gatatgtact     1980

ctcgtaagaa ttctctacgc ctgtggtttt agcgttttgt tgaccagcta tacacactct     2040

gctgttgaca atattctttt gaagttagcc aagtttaaaa taggattttt gcgtttgggt     2100

cagattcaga aggttcatcc agctatccag caatttacag agcaagaaat ttgcagatca     2160

aagtccatta aatccttagc tcttctagaa gaactctaca atagtcaact tatagttgca     2220

acaacatgta tgggaataaa ccatccaata ttttcccgta aaatttttga tttttgtatt     2280

gtggatgaag cctctcaaat tagccaacca atttgtctgg gccccctttt tttttcacgg     2340

agatttgtgt tagtggggga ccatcagcag cttcctcccc tggtgctaaa ccgtgaagca     2400

agagctcttg gcatgagtga aagcttattc aagaggctgg agcagaataa gagtgctgtt     2460

gtacagttaa ccgtgcagta cagaatgaac agtaaaatta tgtccttaag taataagctg     2520

acctatgagg gcaagctgga gtgtggatca gacaaagtgg ccaatgcagt gataaaccta     2580

cgtcacttta aagatgtgaa gctggaactg gaattttatg ctgactattc tgataatcct     2640

tggttgatgg gagtatttga acccaacaat cctgtttgtt tccttaatac agacaaggtt     2700

ccagcgccag aacaagttga aaaaggtggt gtgagcaatg taacagaagc caaactcata     2760

gttttcctaa cctccatttt tgttaaggct ggatgcagtc cctctgatat tggtattatt     2820

gcaccgtaca ggcagcaatt aaagatcatc aatgatttat tggcacgttc tattgggatg     2880

gtcgaagtta atacagtaga caaataccaa ggaagggaca aaagtattgt cctagtatct     2940

tttgttagaa gtaataagga tggaactgtt ggtgaactct tgaaagattg gcgacgtctt     3000

aatgttgcta taaccagagc caaacataaa ctgattcttc tggggtgtgt gccctcacta     3060

aattgctatc ctcctttgga gaagctgctt aatcatttaa actcagaaaa attaatcatt     3120

gatcttccat caagagaaca tgaaagtctt tgccacatat tgggtgactt tcaaagagaa     3180

taa                                                                   3183


<210>  79
<211>  1060
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Glu Gln Leu Asn Glu Leu Glu Leu Leu Met Glu Lys Ser Phe Trp 
1               5                   10                  15      


Glu Glu Ala Glu Leu Pro Ala Glu Leu Phe Gln Lys Lys Val Val Ala 
            20                  25                  30          


Ser Phe Pro Arg Thr Val Leu Ser Thr Gly Met Asp Asn Arg Tyr Leu 
        35                  40                  45              


Val Leu Ala Val Asn Thr Val Gln Asn Lys Glu Gly Asn Cys Glu Lys 
    50                  55                  60                  


Arg Leu Val Ile Thr Ala Ser Gln Ser Leu Glu Asn Lys Glu Leu Cys 
65                  70                  75                  80  


Ile Leu Arg Asn Asp Trp Cys Ser Val Pro Val Glu Pro Gly Asp Ile 
                85                  90                  95      


Ile His Leu Glu Gly Asp Cys Thr Ser Asp Thr Trp Ile Ile Asp Lys 
            100                 105                 110         


Asp Phe Gly Tyr Leu Ile Leu Tyr Pro Asp Met Leu Ile Ser Gly Thr 
        115                 120                 125             


Ser Ile Ala Ser Ser Ile Arg Cys Met Arg Arg Ala Val Leu Ser Glu 
    130                 135                 140                 


Thr Phe Arg Ser Ser Asp Pro Ala Thr Arg Gln Met Leu Ile Gly Thr 
145                 150                 155                 160 


Val Leu His Glu Val Phe Gln Lys Ala Ile Asn Asn Ser Phe Ala Pro 
                165                 170                 175     


Glu Lys Leu Gln Glu Leu Ala Phe Gln Thr Ile Gln Glu Ile Arg His 
            180                 185                 190         


Leu Lys Glu Met Tyr Arg Leu Asn Leu Ser Gln Asp Glu Ile Lys Gln 
        195                 200                 205             


Glu Val Glu Asp Tyr Leu Pro Ser Phe Cys Lys Trp Ala Gly Asp Phe 
    210                 215                 220                 


Met His Lys Asn Thr Ser Thr Asp Phe Pro Gln Met Gln Leu Ser Leu 
225                 230                 235                 240 


Pro Ser Asp Asn Ser Lys Asp Asn Ser Thr Cys Asn Ile Glu Val Val 
                245                 250                 255     


Lys Pro Met Asp Ile Glu Glu Ser Ile Trp Ser Pro Arg Phe Gly Leu 
            260                 265                 270         


Lys Gly Lys Ile Asp Val Thr Val Gly Val Lys Ile His Arg Gly Tyr 
        275                 280                 285             


Lys Thr Lys Tyr Lys Ile Met Pro Leu Glu Leu Lys Thr Gly Lys Glu 
    290                 295                 300                 


Ser Asn Ser Ile Glu His Arg Ser Gln Val Val Leu Tyr Thr Leu Leu 
305                 310                 315                 320 


Ser Gln Glu Arg Arg Ala Asp Pro Glu Ala Gly Leu Leu Leu Tyr Leu 
                325                 330                 335     


Lys Thr Gly Gln Met Tyr Pro Val Pro Ala Asn His Leu Asp Lys Arg 
            340                 345                 350         


Glu Leu Leu Lys Leu Arg Asn Gln Met Ala Phe Ser Leu Phe His Arg 
        355                 360                 365             


Ile Ser Lys Ser Ala Thr Arg Gln Lys Thr Gln Leu Ala Ser Leu Pro 
    370                 375                 380                 


Gln Ile Ile Glu Glu Glu Lys Thr Cys Lys Tyr Cys Ser Gln Ile Gly 
385                 390                 395                 400 


Asn Cys Ala Leu Tyr Ser Arg Ala Val Glu Gln Gln Met Asp Cys Ser 
                405                 410                 415     


Ser Val Pro Ile Val Met Leu Pro Lys Ile Glu Glu Glu Thr Gln His 
            420                 425                 430         


Leu Lys Gln Thr His Leu Glu Tyr Phe Ser Leu Trp Cys Leu Met Leu 
        435                 440                 445             


Thr Leu Glu Ser Gln Ser Lys Asp Asn Lys Lys Asn His Gln Asn Ile 
    450                 455                 460                 


Trp Leu Met Pro Ala Ser Glu Met Glu Lys Ser Gly Ser Cys Ile Gly 
465                 470                 475                 480 


Asn Leu Ile Arg Met Glu His Val Lys Ile Val Cys Asp Gly Gln Tyr 
                485                 490                 495     


Leu His Asn Phe Gln Cys Lys His Gly Ala Ile Pro Val Thr Asn Leu 
            500                 505                 510         


Met Ala Gly Asp Arg Val Ile Val Ser Gly Glu Glu Arg Ser Leu Phe 
        515                 520                 525             


Ala Leu Ser Arg Gly Tyr Val Lys Glu Ile Asn Met Thr Thr Val Thr 
    530                 535                 540                 


Cys Leu Leu Asp Arg Asn Leu Ser Val Leu Pro Glu Ser Thr Leu Phe 
545                 550                 555                 560 


Arg Leu Asp Gln Glu Glu Lys Asn Cys Asp Ile Asp Thr Pro Leu Gly 
                565                 570                 575     


Asn Leu Ser Lys Leu Met Glu Asn Thr Phe Val Ser Lys Lys Leu Arg 
            580                 585                 590         


Asp Leu Ile Ile Asp Phe Arg Glu Pro Gln Phe Ile Ser Tyr Leu Ser 
        595                 600                 605             


Ser Val Leu Pro His Asp Ala Lys Asp Thr Val Ala Cys Ile Leu Lys 
    610                 615                 620                 


Gly Leu Asn Lys Pro Gln Arg Gln Ala Met Lys Lys Val Leu Leu Ser 
625                 630                 635                 640 


Lys Asp Tyr Thr Leu Ile Val Gly Met Pro Gly Thr Gly Lys Thr Thr 
                645                 650                 655     


Thr Ile Cys Thr Leu Val Arg Ile Leu Tyr Ala Cys Gly Phe Ser Val 
            660                 665                 670         


Leu Leu Thr Ser Tyr Thr His Ser Ala Val Asp Asn Ile Leu Leu Lys 
        675                 680                 685             


Leu Ala Lys Phe Lys Ile Gly Phe Leu Arg Leu Gly Gln Ile Gln Lys 
    690                 695                 700                 


Val His Pro Ala Ile Gln Gln Phe Thr Glu Gln Glu Ile Cys Arg Ser 
705                 710                 715                 720 


Lys Ser Ile Lys Ser Leu Ala Leu Leu Glu Glu Leu Tyr Asn Ser Gln 
                725                 730                 735     


Leu Ile Val Ala Thr Thr Cys Met Gly Ile Asn His Pro Ile Phe Ser 
            740                 745                 750         


Arg Lys Ile Phe Asp Phe Cys Ile Val Asp Glu Ala Ser Gln Ile Ser 
        755                 760                 765             


Gln Pro Ile Cys Leu Gly Pro Leu Phe Phe Ser Arg Arg Phe Val Leu 
    770                 775                 780                 


Val Gly Asp His Gln Gln Leu Pro Pro Leu Val Leu Asn Arg Glu Ala 
785                 790                 795                 800 


Arg Ala Leu Gly Met Ser Glu Ser Leu Phe Lys Arg Leu Glu Gln Asn 
                805                 810                 815     


Lys Ser Ala Val Val Gln Leu Thr Val Gln Tyr Arg Met Asn Ser Lys 
            820                 825                 830         


Ile Met Ser Leu Ser Asn Lys Leu Thr Tyr Glu Gly Lys Leu Glu Cys 
        835                 840                 845             


Gly Ser Asp Lys Val Ala Asn Ala Val Ile Asn Leu Arg His Phe Lys 
    850                 855                 860                 


Asp Val Lys Leu Glu Leu Glu Phe Tyr Ala Asp Tyr Ser Asp Asn Pro 
865                 870                 875                 880 


Trp Leu Met Gly Val Phe Glu Pro Asn Asn Pro Val Cys Phe Leu Asn 
                885                 890                 895     


Thr Asp Lys Val Pro Ala Pro Glu Gln Val Glu Lys Gly Gly Val Ser 
            900                 905                 910         


Asn Val Thr Glu Ala Lys Leu Ile Val Phe Leu Thr Ser Ile Phe Val 
        915                 920                 925             


Lys Ala Gly Cys Ser Pro Ser Asp Ile Gly Ile Ile Ala Pro Tyr Arg 
    930                 935                 940                 


Gln Gln Leu Lys Ile Ile Asn Asp Leu Leu Ala Arg Ser Ile Gly Met 
945                 950                 955                 960 


Val Glu Val Asn Thr Val Asp Lys Tyr Gln Gly Arg Asp Lys Ser Ile 
                965                 970                 975     


Val Leu Val Ser Phe Val Arg Ser Asn Lys Asp Gly Thr Val Gly Glu 
            980                 985                 990         


Leu Leu Lys Asp Trp Arg Arg Leu  Asn Val Ala Ile Thr  Arg Ala Lys 
        995                 1000                 1005             


His Lys  Leu Ile Leu Leu Gly  Cys Val Pro Ser Leu  Asn Cys Tyr 
    1010                 1015                 1020             


Pro Pro  Leu Glu Lys Leu Leu  Asn His Leu Asn Ser  Glu Lys Leu 
    1025                 1030                 1035             


Ile Ile  Asp Leu Pro Ser Arg  Glu His Glu Ser Leu  Cys His Ile 
    1040                 1045                 1050             


Leu Gly  Asp Phe Gln Arg Glu  
    1055                 1060 


<210>  80
<211>  2694
<212>  DNA
<213>  Homo sapiens

<400>  80
atgaacatct cgggaagcag ctgtggaagc cctaactctg cagatacatc tagtgacttt       60

aaggaccttt ggacaaaact aaaagaatgt catgatagag aagtacaagg tttacaagta      120

aaagtaacca agctaaaaca ggaacgaatc ttagatgcac aaagactaga agaattcttc      180

accaaaaatc aacagctgag ggaacagcag aaagtccttc atgaaaccat taaagtttta      240

gaagatcggt taagagcagg cttatgtgat cgctgtgcag taactgaaga acatatgcgg      300

aaaaaacagc aagagtttga aaatatccgg cagcagaatc ttaaacttat tacagaactt      360

atgaatgaaa ggaatactct acaggaagaa aataaaaagc tttctgaaca actccagcag      420

aaaattgaga atgatcaaca gcatcaagca gctgagcttg aatgtgagga agacgttatt      480

ccagattcac cgataacagc cttctcattt tctggcgtta accggctacg aagaaaggag      540

aacccccatg tccgatacat agaacaaaca catactaaat tggagcactc tgtgtgtgca      600

aatgaaatga gaaaagtttc caagtcttca actcatccac aacataatcc taatgaaaat      660

gaaattctag tagctgacac ttatgaccaa agtcaatctc caatggccaa agcacatgga      720

acaagcagct atacccctga taagtcatct tttaatttag ctacagttgt tgctgaaaca      780

cttggacttg gtgttcaaga agaatctgaa actcaaggtc ccatgagccc ccttggtgat      840

gagctctacc actgtctgga aggaaatcac aagaaacagc cttttgagga atctacaaga      900

aatactgaag atagtttaag attttcagat tctacttcaa agactcctcc tcaagaagaa      960

ttacctactc gagtgtcatc tcctgtattt ggagctacct ctagtatcaa aagtggttta     1020

gatttgaata caagtttgtc cccttctctt ttacagcctg ggaaaaaaaa acatctgaaa     1080

acactccctt ttagcaacac ttgtatatct agattagaaa aaactagatc aaaatctgaa     1140

gatagtgccc ttttcacaca tcacagtctt gggtctgaag tgaacaagat cattatccag     1200

tcatctaata aacagatact tataaataaa aatataagtg aatccctagg tgaacagaat     1260

aggactgagt acggtaaaga ttctaacact gataaacatt tggagcccct gaaatcattg     1320

ggaggccgaa catccaaaag gaagaaaact gaggaagaaa gtgaacatga agtaagctgc     1380

ccccaagctt cttttgataa agaaaatgct ttcccttttc caatggataa tcagttttcc     1440

atgaatggag actgtgtgat ggataaacct ctggatctgt ctgatcgatt ttcagctatt     1500

cagcgtcaag agaaaagcca aggaagtgag acttctaaaa acaaatttag gcaagtgact     1560

ctttatgagg ctttgaagac cattccaaag ggcttttcct caagccgtaa ggcctcagat     1620

ggcaactgca cgttgcccaa agattcccca ggggagccct gttcacagga atgcatcatc     1680

cttcagccct tgaataaatg ctctccagac aataaaccat cattacaaat aaaagaagaa     1740

aatgctgtct ttaaaattcc tctacgtcca cgtgaaagtt tggagactga gaatgtttta     1800

gatgacataa agagtgctgg ttctcatgag ccaataaaaa tacaaaccag gtcagaccat     1860

ggaggatgtg aacttgcatc agttcttcag ttaaatccat gtagaactgg taaaataaag     1920

tctctacaaa acaaccaaga tgtatccttt gaaaatatcc agtggagtat agatccggga     1980

gcagaccttt ctcagtataa aatggatgtt actgtaatag atacaaagga tggcagtcag     2040

tcaaaattag gaggagagac agtggacatg gactgtacat tggttagtga aaccgttctc     2100

ttaaaaatga agaagcaaga gcagaaggga gaaaaaagtt caaatgaaga aagaaaaatg     2160

aatgatagct tggaagatat gtttgatcgg acaacacatg aagagtatga atcctgtttg     2220

gcagacagtt tctcccaagc agcagatgaa gaggaggaat tgtctactgc cacaaagaaa     2280

ctacacactc atggtgataa acaagacaaa gtcaagcaga aagcgtttgt ggagccgtat     2340

tttaaaggtg atgaaagaga gactagcttg caaaattttc ctcatattga ggtggttcgg     2400

aaaaaagagg agagaagaaa actgcttggg cacacgtgta aggaatgtga aatttattat     2460

gcagatatgc cagcagaaga aagagaaaag aaattggctt cctgctcaag acaccgattc     2520

cgctacattc cacccaacac accagagaat ttttgggaag ttggttttcc ttccactcag     2580

acttgtatgg aaagaggtta tattaaggaa gatcttgatc cttgtcctcg tccaaaaaga     2640

cgtcagcctt acaacgcaat attttctcca aaaggcaagg agcagaagac atag           2694


<210>  81
<211>  897
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp 
            20                  25                  30          


Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu 
        35                  40                  45              


Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln 
    50                  55                  60                  


Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu 
65                  70                  75                  80  


Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu 
                85                  90                  95      


Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln 
            100                 105                 110         


Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln 
        115                 120                 125             


Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn 
    130                 135                 140                 


Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile 
145                 150                 155                 160 


Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu 
                165                 170                 175     


Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr 
            180                 185                 190         


Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys 
        195                 200                 205             


Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val 
    210                 215                 220                 


Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly 
225                 230                 235                 240 


Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val 
                245                 250                 255     


Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln 
            260                 265                 270         


Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly 
        275                 280                 285             


Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp 
    290                 295                 300                 


Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu 
305                 310                 315                 320 


Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile 
                325                 330                 335     


Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln 
            340                 345                 350         


Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys 
        355                 360                 365             


Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu 
    370                 375                 380                 


Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln 
385                 390                 395                 400 


Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu 
                405                 410                 415     


Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys 
            420                 425                 430         


His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys 
        435                 440                 445             


Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser 
    450                 455                 460                 


Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser 
465                 470                 475                 480 


Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg 
                485                 490                 495     


Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser 
            500                 505                 510         


Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile 
        515                 520                 525             


Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr 
    530                 535                 540                 


Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile 
545                 550                 555                 560 


Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln 
                565                 570                 575     


Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu 
            580                 585                 590         


Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser 
        595                 600                 605             


His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu 
    610                 615                 620                 


Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys 
625                 630                 635                 640 


Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser 
                645                 650                 655     


Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val 
            660                 665                 670         


Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val 
        675                 680                 685             


Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys 
    690                 695                 700                 


Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met 
705                 710                 715                 720 


Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr 
                725                 730                 735     


Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu 
            740                 745                 750         


Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln 
        755                 760                 765             


Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp 
    770                 775                 780                 


Glu Arg Glu Thr Ser Leu Gln Asn Phe Pro His Ile Glu Val Val Arg 
785                 790                 795                 800 


Lys Lys Glu Glu Arg Arg Lys Leu Leu Gly His Thr Cys Lys Glu Cys 
                805                 810                 815     


Glu Ile Tyr Tyr Ala Asp Met Pro Ala Glu Glu Arg Glu Lys Lys Leu 
            820                 825                 830         


Ala Ser Cys Ser Arg His Arg Phe Arg Tyr Ile Pro Pro Asn Thr Pro 
        835                 840                 845             


Glu Asn Phe Trp Glu Val Gly Phe Pro Ser Thr Gln Thr Cys Met Glu 
    850                 855                 860                 


Arg Gly Tyr Ile Lys Glu Asp Leu Asp Pro Cys Pro Arg Pro Lys Arg 
865                 870                 875                 880 


Arg Gln Pro Tyr Asn Ala Ile Phe Ser Pro Lys Gly Lys Glu Gln Lys 
                885                 890                 895     


Thr 
    


<210>  82
<211>  2604
<212>  DNA
<213>  Homo sapiens

<400>  82
atgaacatct cgggaagcag ctgtggaagc cctaactctg cagatacatc tagtgacttt       60

aaggaccttt ggacaaaact aaaagaatgt catgatagag aagtacaagg tttacaagta      120

aaagtaacca agctaaaaca ggaacgaatc ttagatgcac aaagactaga agaattcttc      180

accaaaaatc aacagctgag ggaacagcag aaagtccttc atgaaaccat taaagtttta      240

gaagatcggt taagagcagg cttatgtgat cgctgtgcag taactgaaga acatatgcgg      300

aaaaaacagc aagagtttga aaatatccgg cagcagaatc ttaaacttat tacagaactt      360

atgaatgaaa ggaatactct acaggaagaa aataaaaagc tttctgaaca actccagcag      420

aaaattgaga atgatcaaca gcatcaagca gctgagcttg aatgtgagga agacgttatt      480

ccagattcac cgataacagc cttctcattt tctggcgtta accggctacg aagaaaggag      540

aacccccatg tccgatacat agaacaaaca catactaaat tggagcactc tgtgtgtgca      600

aatgaaatga gaaaagtttc caagtcttca actcatccac aacataatcc taatgaaaat      660

gaaattctag tagctgacac ttatgaccaa agtcaatctc caatggccaa agcacatgga      720

acaagcagct atacccctga taagtcatct tttaatttag ctacagttgt tgctgaaaca      780

cttggacttg gtgttcaaga agaatctgaa actcaaggtc ccatgagccc ccttggtgat      840

gagctctacc actgtctgga aggaaatcac aagaaacagc cttttgagga atctacaaga      900

aatactgaag atagtttaag attttcagat tctacttcaa agactcctcc tcaagaagaa      960

ttacctactc gagtgtcatc tcctgtattt ggagctacct ctagtatcaa aagtggttta     1020

gatttgaata caagtttgtc cccttctctt ttacagcctg ggaaaaaaaa acatctgaaa     1080

acactccctt ttagcaacac ttgtatatct agattagaaa aaactagatc aaaatctgaa     1140

gatagtgccc ttttcacaca tcacagtctt gggtctgaag tgaacaagat cattatccag     1200

tcatctaata aacagatact tataaataaa aatataagtg aatccctagg tgaacagaat     1260

aggactgagt acggtaaaga ttctaacact gataaacatt tggagcccct gaaatcattg     1320

ggaggccgaa catccaaaag gaagaaaact gaggaagaaa gtgaacatga agtaagctgc     1380

ccccaagctt cttttgataa agaaaatgct ttcccttttc caatggataa tcagttttcc     1440

atgaatggag actgtgtgat ggataaacct ctggatctgt ctgatcgatt ttcagctatt     1500

cagcgtcaag agaaaagcca aggaagtgag acttctaaaa acaaatttag gcaagtgact     1560

ctttatgagg ctttgaagac cattccaaag ggcttttcct caagccgtaa ggcctcagat     1620

ggcaactgca cgttgcccaa agattcccca ggggagccct gttcacagga atgcatcatc     1680

cttcagccct tgaataaatg ctctccagac aataaaccat cattacaaat aaaagaagaa     1740

aatgctgtct ttaaaattcc tctacgtcca cgtgaaagtt tggagactga gaatgtttta     1800

gatgacataa agagtgctgg ttctcatgag ccaataaaaa tacaaaccag gtcagaccat     1860

ggaggatgtg aacttgcatc agttcttcag ttaaatccat gtagaactgg taaaataaag     1920

tctctacaaa acaaccaaga tgtatccttt gaaaatatcc agtggagtat agatccggga     1980

gcagaccttt ctcagtataa aatggatgtt actgtaatag atacaaagga tggcagtcag     2040

tcaaaattag gaggagagac agtggacatg gactgtacat tggttagtga aaccgttctc     2100

ttaaaaatga agaagcaaga gcagaaggga gaaaaaagtt caaatgaaga aagaaaaatg     2160

aatgatagct tggaagatat gtttgatcgg acaacacatg aagagtatga atcctgtttg     2220

gcagacagtt tctcccaagc agcagatgaa gaggaggaat tgtctactgc cacaaagaaa     2280

ctacacactc atggtgataa acaagacaaa gtcaagcaga aagcgtttgt ggagccgtat     2340

tttaaaggtg atgaaagtat tatgcagata tgccagcaga agaaagagaa aagaaattgg     2400

cttcctgctc aagacaccga ttccgctaca ttccacccaa cacaccagag aatttttggg     2460

aagttggttt tccttccact cagacttgta tggaaagagg ttatattaag gaagatcttg     2520

atccttgtcc tcgtccaaaa agacgtcagc cttacaacgc aatattttct ccaaaaggca     2580

aggagcagaa gacatagacg ttga                                            2604


<210>  83
<211>  867
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp 
            20                  25                  30          


Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu 
        35                  40                  45              


Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln 
    50                  55                  60                  


Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu 
65                  70                  75                  80  


Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu 
                85                  90                  95      


Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln 
            100                 105                 110         


Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln 
        115                 120                 125             


Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn 
    130                 135                 140                 


Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile 
145                 150                 155                 160 


Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu 
                165                 170                 175     


Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr 
            180                 185                 190         


Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys 
        195                 200                 205             


Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val 
    210                 215                 220                 


Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly 
225                 230                 235                 240 


Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val 
                245                 250                 255     


Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln 
            260                 265                 270         


Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly 
        275                 280                 285             


Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp 
    290                 295                 300                 


Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu 
305                 310                 315                 320 


Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile 
                325                 330                 335     


Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln 
            340                 345                 350         


Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys 
        355                 360                 365             


Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu 
    370                 375                 380                 


Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln 
385                 390                 395                 400 


Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu 
                405                 410                 415     


Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys 
            420                 425                 430         


His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys 
        435                 440                 445             


Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser 
    450                 455                 460                 


Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser 
465                 470                 475                 480 


Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg 
                485                 490                 495     


Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser 
            500                 505                 510         


Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile 
        515                 520                 525             


Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr 
    530                 535                 540                 


Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile 
545                 550                 555                 560 


Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln 
                565                 570                 575     


Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu 
            580                 585                 590         


Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser 
        595                 600                 605             


His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu 
    610                 615                 620                 


Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys 
625                 630                 635                 640 


Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser 
                645                 650                 655     


Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val 
            660                 665                 670         


Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val 
        675                 680                 685             


Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys 
    690                 695                 700                 


Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met 
705                 710                 715                 720 


Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr 
                725                 730                 735     


Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu 
            740                 745                 750         


Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln 
        755                 760                 765             


Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp 
    770                 775                 780                 


Glu Ser Ile Met Gln Ile Cys Gln Gln Lys Lys Glu Lys Arg Asn Trp 
785                 790                 795                 800 


Leu Pro Ala Gln Asp Thr Asp Ser Ala Thr Phe His Pro Thr His Gln 
                805                 810                 815     


Arg Ile Phe Gly Lys Leu Val Phe Leu Pro Leu Arg Leu Val Trp Lys 
            820                 825                 830         


Glu Val Ile Leu Arg Lys Ile Leu Ile Leu Val Leu Val Gln Lys Asp 
        835                 840                 845             


Val Ser Leu Thr Thr Gln Tyr Phe Leu Gln Lys Ala Arg Ser Arg Arg 
    850                 855                 860                 


His Arg Arg 
865         


<210>  84
<211>  2127
<212>  DNA
<213>  Homo sapiens

<400>  84
atgagtactg cagatgcact tgatgatgaa aacacattta aaatattagt tgcaacagat       60

attcatcttg gatttatgga gaaagatgca gtcagaggaa atgatacgtt tgtaacactc      120

gatgaaattt taagacttgc ccaggaaaat gaagtggatt ttattttgtt aggtggtgat      180

ctttttcatg aaaataagcc ctcaaggaaa acattacata cctgcctcga gttattaaga      240

aaatattgta tgggtgatcg gcctgtccag tttgaaattc tcagtgatca gtcagtcaac      300

tttggtttta gtaagtttcc atgggtgaac tatcaagatg gcaacctcaa catttcaatt      360

ccagtgttta gtattcatgg caatcatgac gatcccacag gggcagatgc actttgtgcc      420

ttggacattt taagttgtgc tggatttgta aatcactttg gacgttcaat gtctgtggag      480

aagatagaca ttagtccggt tttgcttcaa aaaggaagca caaagattgc gctatatggt      540

ttaggatcca ttccagatga aaggctctat cgaatgtttg tcaataaaaa agtaacaatg      600

ttgagaccaa aggaagatga gaactcttgg tttaacttat ttgtgattca tcagaacagg      660

agtaaacatg gaagtactaa cttcattcca gaacaatttt tggatgactt cattgatctt      720

gttatctggg gccatgaaca tgagtgtaaa atagctccaa ccaaaaatga acaacagctg      780

ttttatatct cacaacctgg aagctcagtg gttacttctc tttccccagg agaagctgta      840

aagaaacatg ttggtttgct gcgtattaaa gggaggaaga tgaatatgca taaaattcct      900

cttcacacag tgcggcagtt tttcatggag gatattgttc tagctaatca tccagacatt      960

tttaacccag ataatcctaa agtaacccaa gccatacaaa gcttctgttt ggagaagatt     1020

gaagaaatgc ttgaaaatgc tgaacgggaa cgtctgggta attctcacca gccagagaag     1080

cctcttgtac gactgcgagt ggactatagt ggaggttttg aacctttcag tgttcttcgc     1140

tttagccaga aatttgtgga tcgggtagct aatccaaaag acattatcca ttttttcagg     1200

catagagaac aaaaggaaaa aacaggagaa gagatcaact ttgggaaact tatcacaaag     1260

ccttcagaag gaacaacttt aagggtagaa gatcttgtaa aacagtactt tcaaaccgca     1320

gagaagaatg tgcagctctc actgctaaca gaaagaggga tgggtgaagc agtacaagaa     1380

tttgtggaca aggaggagaa agatgccatt gaggaattag tgaaatacca gttggaaaaa     1440

acacagcgat ttcttaaaga acgtcatatt gatgccctcg aagacaaaat cgatgaggag     1500

gtacgtcgtt tcagagaaac cagacaaaaa aatactaatg aagaagatga tgaagtccgt     1560

gaggctatga ccagggccag agcactcaga tctcagtcag aggagtctgc ttctgccttt     1620

agtgctgatg accttatgag tatagattta gcagaacaga tggctaatga ctctgatgat     1680

agcatctcag cagcaaccaa caaaggaaga ggccgaggaa gaggtcgaag aggtggaaga     1740

gggcagaatt cagcatcgag aggagggtct caaagaggaa gagcagacac tggtctggag     1800

acttctaccc gtagcaggaa ctcaaagact gctgtgtcag catctagaaa tatgtctatt     1860

atagatgcct ttaaatctac aagacagcag ccttcccgaa atgtcactac taagaattat     1920

tcagaggtga ttgaggtaga tgaatcagat gtggaagaag acatttttcc taccacttca     1980

aagacagatc aaaggtggtc cagcacatca tccagcaaaa tcatgtccca gagtcaagta     2040

tcgaaagggg ttgattttga atcaagtgag gatgatgatg atgatccttt tatgaacact     2100

agttctttaa gaagaaatag aagataa                                         2127


<210>  85
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Ala Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser Arg Asn Ser 
        595                 600                 605             


Lys Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile Asp Ala Phe 
    610                 615                 620                 


Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr Lys Asn Tyr 
625                 630                 635                 640 


Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu Asp Ile Phe 
                645                 650                 655     


Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr Ser Ser Ser 
            660                 665                 670         


Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp Phe Glu Ser 
        675                 680                 685             


Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser Ser Leu Arg 
    690                 695                 700                 


Arg Asn Arg Arg 
705             


<210>  86
<211>  2043
<212>  DNA
<213>  Homo sapiens

<400>  86
atgagtactg cagatgcact tgatgatgaa aacacattta aaatattagt tgcaacagat       60

attcatcttg gatttatgga gaaagatgca gtcagaggaa atgatacgtt tgtaacactc      120

gatgaaattt taagacttgc ccaggaaaat gaagtggatt ttattttgtt aggtggtgat      180

ctttttcatg aaaataagcc ctcaaggaaa acattacata cctgcctcga gttattaaga      240

aaatattgta tgggtgatcg gcctgtccag tttgaaattc tcagtgatca gtcagtcaac      300

tttggtttta gtaagtttcc atgggtgaac tatcaagatg gcaacctcaa catttcaatt      360

ccagtgttta gtattcatgg caatcatgac gatcccacag gggcagatgc actttgtgcc      420

ttggacattt taagttgtgc tggatttgta aatcactttg gacgttcaat gtctgtggag      480

aagatagaca ttagtccggt tttgcttcaa aaaggaagca caaagattgc gctatatggt      540

ttaggatcca ttccagatga aaggctctat cgaatgtttg tcaataaaaa agtaacaatg      600

ttgagaccaa aggaagatga gaactcttgg tttaacttat ttgtgattca tcagaacagg      660

agtaaacatg gaagtactaa cttcattcca gaacaatttt tggatgactt cattgatctt      720

gttatctggg gccatgaaca tgagtgtaaa atagctccaa ccaaaaatga acaacagctg      780

ttttatatct cacaacctgg aagctcagtg gttacttctc tttccccagg agaagctgta      840

aagaaacatg ttggtttgct gcgtattaaa gggaggaaga tgaatatgca taaaattcct      900

cttcacacag tgcggcagtt tttcatggag gatattgttc tagctaatca tccagacatt      960

tttaacccag ataatcctaa agtaacccaa gccatacaaa gcttctgttt ggagaagatt     1020

gaagaaatgc ttgaaaatgc tgaacgggaa cgtctgggta attctcacca gccagagaag     1080

cctcttgtac gactgcgagt ggactatagt ggaggttttg aacctttcag tgttcttcgc     1140

tttagccaga aatttgtgga tcgggtagct aatccaaaag acattatcca ttttttcagg     1200

catagagaac aaaaggaaaa aacaggagaa gagatcaact ttgggaaact tatcacaaag     1260

ccttcagaag gaacaacttt aagggtagaa gatcttgtaa aacagtactt tcaaaccgca     1320

gagaagaatg tgcagctctc actgctaaca gaaagaggga tgggtgaagc agtacaagaa     1380

tttgtggaca aggaggagaa agatgccatt gaggaattag tgaaatacca gttggaaaaa     1440

acacagcgat ttcttaaaga acgtcatatt gatgccctcg aagacaaaat cgatgaggag     1500

gtacgtcgtt tcagagaaac cagacaaaaa aatactaatg aagaagatga tgaagtccgt     1560

gaggctatga ccagggccag agcactcaga tctcagtcag aggagtctgc ttctgccttt     1620

agtgctgatg accttatgag tatagattta gcagaacaga tggctaatga ctctgatgat     1680

agcatctcag cagcaaccaa caaaggaaga ggccgaggaa gaggtcgaag aggtggaaga     1740

gggcagaatt cagcatcgag aggagggtct caaagaggaa gagcctttaa atctacaaga     1800

cagcagcctt cccgaaatgt cactactaag aattattcag aggtgattga ggtagatgaa     1860

tcagatgtgg aagaagacat ttttcctacc acttcaaaga cagatcaaag gtggtccagc     1920

acatcatcca gcaaaatcat gtcccagagt caagtatcga aaggggttga ttttgaatca     1980

agtgaggatg atgatgatga tccttttatg aacactagtt ctttaagaag aaatagaaga     2040

taa                                                                   2043


<210>  87
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Ala Phe Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr 
        595                 600                 605             


Thr Lys Asn Tyr Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu 
    610                 615                 620                 


Glu Asp Ile Phe Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser 
625                 630                 635                 640 


Thr Ser Ser Ser Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val 
                645                 650                 655     


Asp Phe Glu Ser Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr 
            660                 665                 670         


Ser Ser Leu Arg Arg Asn Arg Arg 
        675                 680 


<210>  88
<211>  2124
<212>  DNA
<213>  Homo sapiens

<400>  88
atgagtactg cagatgcact tgatgatgaa aacacattta aaatattagt tgcaacagat       60

attcatcttg gatttatgga gaaagatgca gtcagaggaa atgatacgtt tgtaacactc      120

gatgaaattt taagacttgc ccaggaaaat gaagtggatt ttattttgtt aggtggtgat      180

ctttttcatg aaaataagcc ctcaaggaaa acattacata cctgcctcga gttattaaga      240

aaatattgta tgggtgatcg gcctgtccag tttgaaattc tcagtgatca gtcagtcaac      300

tttggtttta gtaagtttcc atgggtgaac tatcaagatg gcaacctcaa catttcaatt      360

ccagtgttta gtattcatgg caatcatgac gatcccacag gggcagatgc actttgtgcc      420

ttggacattt taagttgtgc tggatttgta aatcactttg gacgttcaat gtctgtggag      480

aagatagaca ttagtccggt tttgcttcaa aaaggaagca caaagattgc gctatatggt      540

ttaggatcca ttccagatga aaggctctat cgaatgtttg tcaataaaaa agtaacaatg      600

ttgagaccaa aggaagatga gaactcttgg tttaacttat ttgtgattca tcagaacagg      660

agtaaacatg gaagtactaa cttcattcca gaacaatttt tggatgactt cattgatctt      720

gttatctggg gccatgaaca tgagtgtaaa atagctccaa ccaaaaatga acaacagctg      780

ttttatatct cacaacctgg aagctcagtg gttacttctc tttccccagg agaagctgta      840

aagaaacatg ttggtttgct gcgtattaaa gggaggaaga tgaatatgca taaaattcct      900

cttcacacag tgcggcagtt tttcatggag gatattgttc tagctaatca tccagacatt      960

tttaacccag ataatcctaa agtaacccaa gccatacaaa gcttctgttt ggagaagatt     1020

gaagaaatgc ttgaaaatgc tgaacgggaa cgtctgggta attctcacca gccagagaag     1080

cctcttgtac gactgcgagt ggactatagt ggaggttttg aacctttcag tgttcttcgc     1140

tttagccaga aatttgtgga tcgggtagct aatccaaaag acattatcca ttttttcagg     1200

catagagaac aaaaggaaaa aacaggagaa gagatcaact ttgggaaact tatcacaaag     1260

ccttcagaag gaacaacttt aagggtagaa gatcttgtaa aacagtactt tcaaaccgca     1320

gagaagaatg tgcagctctc actgctaaca gaaagaggga tgggtgaagc agtacaagaa     1380

tttgtggaca aggaggagaa agatgccatt gaggaattag tgaaatacca gttggaaaaa     1440

acacagcgat ttcttaaaga acgtcatatt gatgccctcg aagacaaaat cgatgaggag     1500

gtacgtcgtt tcagagaaac cagacaaaaa aatactaatg aagaagatga tgaagtccgt     1560

gaggctatga ccagggccag agcactcaga tctcagtcag aggagtctgc ttctgccttt     1620

agtgctgatg accttatgag tatagattta gcagaacaga tggctaatga ctctgatgat     1680

agcatctcag cagcaaccaa caaaggaaga ggccgaggaa gaggtcgaag aggtggaaga     1740

gggcagaatt cagcatcgag aggagggtct caaagaggaa gagacactgg tctggagact     1800

tctacccgta gcaggaactc aaagactgct gtgtcagcat ctagaaatat gtctattata     1860

gatgccttta aatctacaag acagcagcct tcccgaaatg tcactactaa gaattattca     1920

gaggtgattg aggtagatga atcagatgtg gaagaagaca tttttcctac cacttcaaag     1980

acagatcaaa ggtggtccag cacatcatcc agcaaaatca tgtcccagag tcaagtatcg     2040

aaaggggttg attttgaatc aagtgaggat gatgatgatg atccttttat gaacactagt     2100

tctttaagaa gaaatagaag ataa                                            2124


<210>  89
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser Arg Asn Ser Lys 
        595                 600                 605             


Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile Asp Ala Phe Lys 
    610                 615                 620                 


Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr Lys Asn Tyr Ser 
625                 630                 635                 640 


Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu Asp Ile Phe Pro 
                645                 650                 655     


Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr Ser Ser Ser Lys 
            660                 665                 670         


Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp Phe Glu Ser Ser 
        675                 680                 685             


Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser Ser Leu Arg Arg 
    690                 695                 700                 


Asn Arg Arg 
705         


<210>  90
<211>  2644
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg 
1               5                   10                  15      


Glu Leu Gly Ser Ala Thr Pro Glu Glu Tyr Asn Thr Val Val Gln Lys 
            20                  25                  30          


Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Thr Asp Val 
        35                  40                  45              


Asn Val Val Ala Val Glu Leu Val Lys Lys Thr Asp Ser Gln Pro Thr 
    50                  55                  60                  


Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro 
65                  70                  75                  80  


Leu Met Phe Val Asn Val Ser Gly Ser His Glu Ala Lys Gly Ser Cys 
                85                  90                  95      


Ile Glu Phe Ser Asn Trp Ile Ile Thr Arg Leu Leu Arg Ile Ala Ala 
            100                 105                 110         


Thr Pro Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys 
        115                 120                 125             


Ser Leu Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val 
    130                 135                 140                 


Leu Thr Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His 
145                 150                 155                 160 


Arg Arg Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser 
                165                 170                 175     


Arg Phe Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala 
            180                 185                 190         


Pro Leu Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Thr 
        195                 200                 205             


Leu Leu Met Val Leu Thr Arg Ile Ile Ala Ile Val Phe Phe Arg Arg 
    210                 215                 220                 


Gln Glu Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly 
225                 230                 235                 240 


Ser Pro Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Thr Glu Leu Phe 
                245                 250                 255     


Gln Leu Gly Gly Leu Pro Ala Gln Pro Ala Ser Thr Phe Phe Ser Ser 
            260                 265                 270         


Phe Leu Glu Leu Leu Lys His Leu Val Glu Met Asp Thr Asp Gln Leu 
        275                 280                 285             


Lys Leu Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Thr Leu Phe Pro 
    290                 295                 300                 


Phe Glu Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met 
305                 310                 315                 320 


Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg 
                325                 330                 335     


Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr 
            340                 345                 350         


Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg 
        355                 360                 365             


Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly 
    370                 375                 380                 


Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu 
385                 390                 395                 400 


Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Thr Gln 
                405                 410                 415     


Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Thr 
        435                 440                 445             


Glu Glu Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser 
    450                 455                 460                 


Ala Leu Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser 
465                 470                 475                 480 


Gly Leu Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val 
                485                 490                 495     


Leu Gln Leu Thr Ala Leu Cys Thr Val His Cys Ser His Gln Asn Met 
            500                 505                 510         


Asn Cys Arg Thr Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro 
        515                 520                 525             


Ser Val Val Ile Thr Trp Met Ser Leu Asp Phe Tyr Thr Lys Val Leu 
    530                 535                 540                 


Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu 
545                 550                 555                 560 


Ala Thr Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met 
                565                 570                 575     


Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly 
            580                 585                 590         


Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu 
        595                 600                 605             


Lys Leu Thr Thr Phe Ala Ala Asn Leu Leu Thr Leu Ser Cys Arg Ile 
    610                 615                 620                 


Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu 
625                 630                 635                 640 


Thr Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Thr Ala Val Tyr 
                645                 650                 655     


Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val 
            660                 665                 670         


Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val 
        675                 680                 685             


Pro Lys Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys 
    690                 695                 700                 


Lys Glu Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Thr Leu His Gly 
705                 710                 715                 720 


Met Phe Tyr Leu Thr Ser Ser Leu Thr Glu Pro Phe Ser Glu His Gly 
                725                 730                 735     


His Val Asp Leu Phe Cys Arg Asn Leu Lys Ala Thr Ser Gln His Glu 
            740                 745                 750         


Cys Ser Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe 
        755                 760                 765             


Leu Leu Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp 
    770                 775                 780                 


Asn Leu His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Thr 
785                 790                 795                 800 


Asp Val Lys Ala Val Leu Gly Thr Leu Leu Asn Leu Met Glu Asp Pro 
                805                 810                 815     


Asp Lys Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu 
            820                 825                 830         


Glu Ser Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu 
        835                 840                 845             


Arg Met Lys Glu Ala Tyr Thr His Ala Gln Ile Ser Arg Asn Asn Glu 
    850                 855                 860                 


Leu Lys Asp Thr Leu Ile Leu Thr Thr Gly Asp Ile Gly Arg Ala Ala 
865                 870                 875                 880 


Lys Gly Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu 
                885                 890                 895     


Leu Ser Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Thr Glu Ile Arg 
            900                 905                 910         


Ala Leu Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln 
        915                 920                 925             


Tyr Lys Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser 
    930                 935                 940                 


Gln Met Thr Ala Leu Pro Asn Thr Pro Cys Gln Asn Ala Asp Val Arg 
945                 950                 955                 960 


Lys Gln Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Thr Leu Ser 
                965                 970                 975     


Glu Ile Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Thr 
            980                 985                 990         


Arg Thr Leu Gln Val Leu Leu Pro  Asp Leu Ala Ala Lys  Ala Ser Pro 
        995                 1000                 1005             


Ala Ala  Ser Ala Leu Ile Arg  Thr Leu Gly Lys Gln  Leu Asn Val 
    1010                 1015                 1020             


Asn Arg  Arg Glu Ile Leu Ile  Asn Asn Phe Lys Tyr  Ile Phe Ser 
    1025                 1030                 1035             


His Leu  Val Cys Ser Cys Ser  Lys Asp Glu Leu Glu  Arg Ala Leu 
    1040                 1045                 1050             


His Tyr  Leu Lys Asn Glu Thr  Glu Ile Glu Leu Gly  Ser Leu Leu 
    1055                 1060                 1065             


Arg Gln  Asp Phe Gln Gly Leu  His Asn Glu Leu Leu  Leu Arg Ile 
    1070                 1075                 1080             


Gly Glu  His Tyr Gln Gln Val  Phe Asn Gly Leu Ser  Ile Leu Ala 
    1085                 1090                 1095             


Ser Phe  Ala Ser Ser Asp Asp  Pro Tyr Gln Gly Pro  Arg Asp Ile 
    1100                 1105                 1110             


Ile Ser  Pro Glu Leu Met Ala  Asp Tyr Leu Gln Pro  Lys Leu Leu 
    1115                 1120                 1125             


Gly Ile  Leu Ala Phe Phe Asn  Met Gln Leu Leu Ser  Ser Ser Val 
    1130                 1135                 1140             


Gly Ile  Glu Asp Lys Lys Met  Ala Leu Asn Ser Leu  Met Ser Leu 
    1145                 1150                 1155             


Met Lys  Leu Met Gly Pro Lys  His Val Ser Ser Val  Arg Val Lys 
    1160                 1165                 1170             


Met Met  Thr Thr Leu Arg Thr  Gly Leu Arg Phe Lys  Asp Asp Phe 
    1175                 1180                 1185             


Pro Glu  Leu Cys Cys Arg Ala  Trp Asp Cys Phe Val  Arg Cys Leu 
    1190                 1195                 1200             


Asp His  Ala Cys Leu Gly Ser  Leu Leu Ser His Val  Ile Val Ala 
    1205                 1210                 1215             


Leu Leu  Pro Leu Ile His Ile  Gln Pro Lys Glu Thr  Ala Ala Ile 
    1220                 1225                 1230             


Phe His  Tyr Leu Ile Ile Glu  Asn Arg Asp Ala Val  Gln Asp Phe 
    1235                 1240                 1245             


Leu His  Glu Ile Tyr Phe Leu  Pro Asp His Pro Glu  Leu Lys Lys 
    1250                 1255                 1260             


Ile Lys  Ala Val Leu Gln Glu  Tyr Arg Lys Glu Thr  Ser Glu Ser 
    1265                 1270                 1275             


Thr Asp  Leu Gln Thr Thr Leu  Gln Leu Ser Met Lys  Ala Ile Gln 
    1280                 1285                 1290             


His Glu  Asn Val Asp Val Arg  Ile His Ala Leu Thr  Ser Leu Lys 
    1295                 1300                 1305             


Glu Thr  Leu Tyr Lys Asn Gln  Glu Lys Leu Ile Lys  Tyr Ala Thr 
    1310                 1315                 1320             


Asp Ser  Glu Thr Val Glu Pro  Ile Ile Ser Gln Leu  Val Thr Val 
    1325                 1330                 1335             


Leu Leu  Lys Gly Cys Gln Asp  Ala Asn Ser Gln Ala  Arg Leu Leu 
    1340                 1345                 1350             


Cys Gly  Glu Cys Leu Gly Glu  Leu Gly Ala Ile Asp  Pro Gly Arg 
    1355                 1360                 1365             


Leu Asp  Phe Ser Thr Thr Glu  Thr Gln Gly Lys Asp  Phe Thr Phe 
    1370                 1375                 1380             


Val Thr  Gly Val Glu Asp Ser  Ser Phe Ala Tyr Gly  Leu Leu Met 
    1385                 1390                 1395             


Glu Leu  Thr Arg Ala Tyr Leu  Ala Tyr Ala Asp Asn  Ser Arg Ala 
    1400                 1405                 1410             


Gln Asp  Ser Ala Ala Tyr Ala  Ile Gln Glu Leu Leu  Ser Ile Tyr 
    1415                 1420                 1425             


Asp Cys  Arg Glu Met Glu Thr  Asn Gly Pro Gly His  Gln Leu Trp 
    1430                 1435                 1440             


Arg Arg  Phe Pro Glu His Val  Arg Glu Ile Leu Glu  Pro His Leu 
    1445                 1450                 1455             


Asn Thr  Arg Tyr Lys Ser Ser  Gln Lys Ser Thr Asp  Trp Ser Gly 
    1460                 1465                 1470             


Val Lys  Lys Pro Ile Tyr Leu  Ser Lys Leu Gly Ser  Asn Phe Ala 
    1475                 1480                 1485             


Glu Trp  Ser Ala Ser Trp Ala  Gly Tyr Leu Ile Thr  Lys Val Arg 
    1490                 1495                 1500             


His Asp  Leu Ala Ser Lys Ile  Phe Thr Cys Cys Ser  Ile Met Met 
    1505                 1510                 1515             


Lys His  Asp Phe Lys Val Thr  Ile Tyr Leu Leu Pro  His Ile Leu 
    1520                 1525                 1530             


Val Tyr  Val Leu Leu Gly Cys  Asn Gln Glu Asp Gln  Gln Glu Val 
    1535                 1540                 1545             


Tyr Ala  Glu Ile Met Ala Val  Leu Lys His Asp Asp  Gln His Thr 
    1550                 1555                 1560             


Ile Asn  Thr Gln Asp Ile Ala  Ser Asp Leu Cys Gln  Leu Ser Thr 
    1565                 1570                 1575             


Gln Thr  Val Phe Ser Met Leu  Asp His Leu Thr Gln  Trp Ala Arg 
    1580                 1585                 1590             


His Lys  Phe Gln Ala Leu Lys  Ala Glu Lys Cys Pro  His Ser Lys 
    1595                 1600                 1605             


Ser Asn  Arg Asn Lys Val Asp  Ser Met Val Ser Thr  Val Asp Tyr 
    1610                 1615                 1620             


Glu Asp  Tyr Gln Ser Val Thr  Arg Phe Leu Asp Leu  Ile Pro Gln 
    1625                 1630                 1635             


Asp Thr  Leu Ala Val Ala Ser  Phe Arg Ser Lys Ala  Tyr Thr Arg 
    1640                 1645                 1650             


Ala Val  Met His Phe Glu Ser  Phe Ile Thr Glu Lys  Lys Gln Asn 
    1655                 1660                 1665             


Ile Gln  Glu His Leu Gly Phe  Leu Gln Lys Leu Tyr  Ala Ala Met 
    1670                 1675                 1680             


His Glu  Pro Asp Gly Val Ala  Gly Val Ser Ala Ile  Arg Lys Ala 
    1685                 1690                 1695             


Glu Pro  Ser Leu Lys Glu Gln  Ile Leu Glu His Glu  Ser Leu Gly 
    1700                 1705                 1710             


Leu Leu  Arg Asp Ala Thr Ala  Cys Tyr Asp Arg Ala  Ile Gln Leu 
    1715                 1720                 1725             


Glu Pro  Asp Gln Ile Ile His  Tyr His Gly Val Val  Lys Ser Met 
    1730                 1735                 1740             


Leu Gly  Leu Gly Gln Leu Ser  Thr Val Ile Thr Gln  Val Asn Gly 
    1745                 1750                 1755             


Val His  Ala Asn Arg Ser Glu  Trp Thr Asp Glu Leu  Asn Thr Tyr 
    1760                 1765                 1770             


Arg Val  Glu Ala Ala Trp Lys  Leu Ser Gln Trp Asp  Leu Val Glu 
    1775                 1780                 1785             


Asn Tyr  Leu Ala Ala Asp Gly  Lys Ser Thr Thr Trp  Ser Val Arg 
    1790                 1795                 1800             


Leu Gly  Gln Leu Leu Leu Ser  Ala Lys Lys Arg Asp  Ile Thr Ala 
    1805                 1810                 1815             


Phe Tyr  Asp Ser Leu Lys Leu  Val Arg Ala Glu Gln  Ile Val Pro 
    1820                 1825                 1830             


Leu Ser  Ala Ala Ser Phe Glu  Arg Gly Ser Tyr Gln  Arg Gly Tyr 
    1835                 1840                 1845             


Glu Tyr  Ile Val Arg Leu His  Met Leu Cys Glu Leu  Glu His Ser 
    1850                 1855                 1860             


Ile Lys  Pro Leu Phe Gln His  Ser Pro Gly Asp Ser  Ser Gln Glu 
    1865                 1870                 1875             


Asp Ser  Leu Asn Trp Val Ala  Arg Leu Glu Met Thr  Gln Asn Ser 
    1880                 1885                 1890             


Tyr Arg  Ala Lys Glu Pro Ile  Leu Ala Leu Arg Arg  Ala Leu Leu 
    1895                 1900                 1905             


Ser Leu  Asn Lys Arg Pro Asp  Tyr Asn Glu Met Val  Gly Glu Cys 
    1910                 1915                 1920             


Trp Leu  Gln Ser Ala Arg Val  Ala Arg Lys Ala Gly  His His Gln 
    1925                 1930                 1935             


Thr Ala  Tyr Asn Ala Leu Leu  Asn Ala Gly Glu Ser  Arg Leu Ala 
    1940                 1945                 1950             


Glu Leu  Tyr Val Glu Arg Ala  Lys Trp Leu Trp Ser  Lys Gly Asp 
    1955                 1960                 1965             


Val His  Gln Ala Leu Ile Val  Leu Gln Lys Gly Val  Glu Leu Cys 
    1970                 1975                 1980             


Phe Pro  Glu Asn Glu Thr Pro  Pro Glu Gly Lys Asn  Met Leu Ile 
    1985                 1990                 1995             


His Gly  Arg Ala Met Leu Leu  Val Gly Arg Phe Met  Glu Glu Thr 
    2000                 2005                 2010             


Ala Asn  Phe Glu Ser Asn Ala  Ile Met Lys Lys Tyr  Lys Asp Val 
    2015                 2020                 2025             


Thr Ala  Cys Leu Pro Glu Trp  Glu Asp Gly His Phe  Tyr Leu Ala 
    2030                 2035                 2040             


Lys Tyr  Tyr Asp Lys Leu Met  Pro Met Val Thr Asp  Asn Lys Met 
    2045                 2050                 2055             


Glu Lys  Gln Gly Asp Leu Ile  Arg Tyr Ile Val Leu  His Phe Gly 
    2060                 2065                 2070             


Arg Ser  Leu Gln Tyr Gly Asn  Gln Phe Ile Tyr Gln  Ser Met Pro 
    2075                 2080                 2085             


Arg Met  Leu Thr Leu Trp Leu  Asp Tyr Gly Thr Lys  Ala Tyr Glu 
    2090                 2095                 2100             


Trp Glu  Lys Ala Gly Arg Ser  Asp Arg Val Gln Met  Arg Asn Asp 
    2105                 2110                 2115             


Leu Gly  Lys Ile Asn Lys Val  Ile Thr Glu His Thr  Asn Tyr Leu 
    2120                 2125                 2130             


Ala Pro  Tyr Gln Phe Leu Thr  Ala Phe Ser Gln Leu  Ile Ser Arg 
    2135                 2140                 2145             


Ile Cys  His Ser His Asp Glu  Val Phe Val Val Leu  Met Glu Ile 
    2150                 2155                 2160             


Ile Ala  Lys Val Phe Leu Ala  Tyr Pro Gln Gln Ala  Met Trp Met 
    2165                 2170                 2175             


Met Thr  Ala Val Ser Lys Ser  Ser Tyr Pro Met Arg  Val Asn Arg 
    2180                 2185                 2190             


Cys Lys  Glu Ile Leu Asn Lys  Ala Ile His Met Lys  Lys Ser Leu 
    2195                 2200                 2205             


Glu Lys  Phe Val Gly Asp Ala  Thr Arg Leu Thr Asp  Lys Leu Leu 
    2210                 2215                 2220             


Glu Leu  Cys Asn Lys Pro Val  Asp Gly Ser Ser Ser  Thr Leu Ser 
    2225                 2230                 2235             


Met Ser  Thr His Phe Lys Met  Leu Lys Lys Leu Val  Glu Glu Ala 
    2240                 2245                 2250             


Thr Phe  Ser Glu Ile Leu Ile  Pro Leu Gln Ser Val  Met Ile Pro 
    2255                 2260                 2265             


Thr Leu  Pro Ser Ile Leu Gly  Thr His Ala Asn His  Ala Ser His 
    2270                 2275                 2280             


Glu Pro  Phe Pro Gly His Trp  Ala Tyr Ile Ala Gly  Phe Asp Asp 
    2285                 2290                 2295             


Met Val  Glu Ile Leu Ala Ser  Leu Gln Lys Pro Lys  Lys Ile Ser 
    2300                 2305                 2310             


Leu Lys  Gly Ser Asp Gly Lys  Phe Tyr Ile Met Met  Cys Lys Pro 
    2315                 2320                 2325             


Lys Asp  Asp Leu Arg Lys Asp  Cys Arg Leu Met Glu  Phe Asn Ser 
    2330                 2335                 2340             


Leu Ile  Asn Lys Cys Leu Arg  Lys Asp Ala Glu Ser  Arg Arg Arg 
    2345                 2350                 2355             


Glu Leu  His Ile Arg Thr Tyr  Ala Val Ile Pro Leu  Asn Asp Glu 
    2360                 2365                 2370             


Cys Gly  Ile Ile Glu Trp Val  Asn Asn Thr Ala Gly  Leu Arg Pro 
    2375                 2380                 2385             


Ile Leu  Thr Lys Leu Tyr Lys  Glu Lys Gly Val Tyr  Met Thr Gly 
    2390                 2395                 2400             


Lys Glu  Leu Arg Gln Cys Met  Leu Pro Lys Ser Ala  Ala Leu Ser 
    2405                 2410                 2415             


Glu Lys  Leu Lys Val Phe Arg  Glu Phe Leu Leu Pro  Arg His Pro 
    2420                 2425                 2430             


Pro Ile  Phe His Glu Trp Phe  Leu Arg Thr Phe Pro  Asp Pro Thr 
    2435                 2440                 2445             


Ser Trp  Tyr Ser Ser Arg Ser  Ala Tyr Cys Arg Ser  Thr Ala Val 
    2450                 2455                 2460             


Met Ser  Met Val Gly Tyr Ile  Leu Gly Leu Gly Asp  Arg His Gly 
    2465                 2470                 2475             


Glu Asn  Ile Leu Phe Asp Ser  Leu Thr Gly Glu Cys  Val His Val 
    2480                 2485                 2490             


Asp Phe  Asn Cys Leu Phe Asn  Lys Gly Glu Thr Phe  Glu Val Pro 
    2495                 2500                 2505             


Glu Ile  Val Pro Phe Arg Leu  Thr His Asn Met Val  Asn Gly Met 
    2510                 2515                 2520             


Gly Pro  Met Gly Thr Glu Gly  Leu Phe Arg Arg Ala  Cys Glu Val 
    2525                 2530                 2535             


Thr Met  Arg Leu Met Arg Asp  Gln Arg Glu Pro Leu  Met Ser Val 
    2540                 2545                 2550             


Leu Lys  Thr Phe Leu His Asp  Pro Leu Val Glu Trp  Ser Lys Pro 
    2555                 2560                 2565             


Val Lys  Gly His Ser Lys Ala  Pro Leu Asn Glu Thr  Gly Glu Val 
    2570                 2575                 2580             


Val Asn  Glu Lys Ala Lys Thr  His Val Leu Asp Ile  Glu Gln Arg 
    2585                 2590                 2595             


Leu Gln  Gly Val Ile Lys Thr  Arg Asn Arg Val Thr  Gly Leu Pro 
    2600                 2605                 2610             


Leu Ser  Ile Glu Gly His Val  His Tyr Leu Ile Gln  Glu Ala Thr 
    2615                 2620                 2625             


Asp Glu  Asn Leu Leu Cys Gln  Met Tyr Leu Gly Trp  Thr Pro Tyr 
    2630                 2635                 2640             


Met 
    


<210>  91
<211>  8158
<212>  DNA
<213>  Homo sapiens

<400>  91
gtggttgact agtgcctcgc agcctcagca tgggggaaca tggcctggag ctggcttcca       60

tgatccccgc cctgcgggag ctgggcagtg ccacaccaga ggaatataat acagttgtac      120

agaagccaag acaaattctg tgtcaattca ttgaccggat acttacagat gtaaatgttg      180

ttgctgtaga acttgtaaag aaaactgact ctcagccaac ctccgtgatg ttgcttgatt      240

tcatccagca tatcatgaaa tcctccccac ttatgtttgt aaatgtgagt ggaagccatg      300

aggccaaagg cagttgtatt gaattcagta attggatcat aacgagactt ctgcggattg      360

cagcaactcc ctcctgtcat ttgttacaca agaaaatctg tgaagtcatc tgttcattat      420

tatttctttt taaaagcaag agtcctgcta tttttggggt actcacaaaa gaattattac      480

aactttttga agacttggtt tacctccata gaagaaatgt gatgggtcat gctgtggaat      540

ggccagtggt catgagccga tttttaagtc aattagatga acacatggga tatttacaat      600

cagctccttt gcagttgatg agtatgcaaa atttagaatt tattgaagtc actttattaa      660

tggttcttac tcgtattatt gcaattgtgt tttttagaag gcaagaactc ttactttggc      720

agataggttg tgttctgcta gagtatggta gtccaaaaat taaatcccta gcaattagct      780

ttttaacaga actttttcag cttggaggac taccagcaca accagctagc acttttttca      840

gctcattttt ggaattatta aaacaccttg tagaaatgga tactgaccaa ttgaaactct      900

atgaagagcc attatcaaag ctgataaaga cactatttcc ctttgaagca gaagcttata      960

gaaatattga acctgtctat ttaaatatgc tgctggaaaa actctgtgtc atgtttgaag     1020

acggtgtgct catgcggctt aagtctgatt tgctaaaagc agctttgtgc catttactgc     1080

agtatttcct taaatttgtg ccagctgggt atgaatctgc tttacaagtc aggaaggtct     1140

atgtgagaaa tatttgtaaa gctcttttgg atgtgcttgg aattgaggta gatgcagagt     1200

acttgttggg cccactttat gcagctttga aaatggaaag tatggaaatc attgaggaga     1260

ttcaatgcca aactcaacag gaaaacctca gcagtaatag tgatggaata tcacccaaaa     1320

ggcgtcgtct cagctcgtct ctaaaccctt ctaaaagagc accaaaacag actgaggaaa     1380

ttaaacatgt ggacatgaac caaaagagca tattatggag tgcactgaaa cagaaagctg     1440

aatcccttca gatttccctt gaatacagtg gcctaaagaa tcctgttatt gagatgttag     1500

aaggaattgc tgttgtctta caactgactg ctctgtgtac tgttcattgt tctcatcaaa     1560

acatgaactg ccgtactttc aaggactgtc aacataaatc caagaagaaa ccttctgtag     1620

tgataacttg gatgtcattg gatttttaca caaaagtgct taagagctgt agaagtttgt     1680

tagaatctgt tcagaaactg gacctggagg caaccattga taaggtggtg aaaatttatg     1740

atgctttgat ttatatgcaa gtaaacagtt catttgaaga tcatatcctg gaagatttat     1800

gtggtatgct ctcacttcca tggatttatt cccattctga tgatggctgt ttaaagttga     1860

ccacatttgc cgctaatctt ctaacattaa gctgtaggat ttcagatagc tattcaccac     1920

aggcacaatc acgatgtgtg tttcttctga ctctgtttcc aagaagaata ttccttgagt     1980

ggagaacagc agtttacaac tgggccctgc agagctccca tgaagtaatc cgggctagtt     2040

gtgttagtgg attttttatc ttattgcagc agcagaattc ttgtaacaga gttcccaaga     2100

ttcttataga taaagtcaaa gatgattctg acattgtcaa gaaagaattt gcttctatac     2160

ttggtcaact tgtctgtact cttcacggca tgttttatct gacaagttct ttaacagaac     2220

ctttctctga acacggacat gtggacctct tctgtaggaa cttgaaagcc acttctcaac     2280

atgaatgttc atcttctcaa ctaaaagctt ctgtctgcaa gccattcctt ttcctactga     2340

aaaaaaaaat acctagtcca gtaaaacttg ctttcataga taatctacat catctttgta     2400

agcatcttga ttttagagaa gatgaaacag atgtaaaagc agttcttgga actttattaa     2460

atttaatgga agatccagac aaagatgtta gagtggcttt tagtggaaat atcaagcaca     2520

tattggaatc cttggactct gaagatggat ttataaagga gctttttgtc ttaagaatga     2580

aggaagcata tacacatgcc caaatatcaa gaaataatga gctgaaggat accttgattc     2640

ttacaacagg ggatattgga agggccgcaa aaggagattt ggtaccattt gcactcttac     2700

acttattgca ttgtttgtta tccaagtcag catctgtctc tggagcagca tacacagaaa     2760

ttagagctct ggttgcagct aaaagtgtta aactgcaaag ttttttcagc cagtataaga     2820

aacccatctg tcagtttttg gtagaatccc ttcactctag tcagatgaca gcacttccga     2880

atactccatg ccagaatgct gacgtgcgaa aacaagatgt ggctcaccag agagaaatgg     2940

ctttaaatac gttgtctgaa attgccaacg ttttcgactt tcctgatctt aatcgttttc     3000

ttactaggac attacaagtt ctactacctg atcttgctgc caaagcaagc cctgcagctt     3060

ctgctctcat tcgaacttta ggaaaacaat taaatgtcaa tcgtagagag attttaataa     3120

acaacttcaa atatattttt tctcatttgg tctgttcttg ttccaaagat gaattagaac     3180

gtgcccttca ttatctgaag aatgaaacag aaattgaact ggggagcctg ttgagacaag     3240

atttccaagg attgcataat gaattattgc tgcgtattgg agaacactat caacaggttt     3300

ttaatggttt gtcaatactt gcctcatttg catccagtga tgatccatat cagggcccga     3360

gagatatcat atcacctgaa ctgatggctg attatttaca acccaaattg ttgggcattt     3420

tggctttttt taacatgcag ttactgagct ctagtgttgg cattgaagat aagaaaatgg     3480

ccttgaacag tttgatgtct ttgatgaagt taatgggacc caaacatgtc agttctgtga     3540

gggtgaagat gatgaccaca ctgagaactg gccttcgatt caaggatgat tttcctgaat     3600

tgtgttgcag agcttgggac tgctttgttc gctgcctgga tcatgcttgt ctgggctccc     3660

ttctcagtca tgtaatagta gctttgttac ctcttataca catccagcct aaagaaactg     3720

cagctatctt ccactacctc ataattgaaa acagggatgc tgtgcaagat tttcttcatg     3780

aaatatattt tttacctgat catccagaat taaaaaagat aaaagccgtt ctccaggaat     3840

acagaaagga gacctctgag agcactgatc ttcagacaac tcttcagctc tctatgaagg     3900

ccattcaaca tgaaaatgtc gatgttcgta ttcatgctct tacaagcttg aaggaaacct     3960

tgtataaaaa tcaggaaaaa ctgataaagt atgcaacaga cagtgaaaca gtagaaccta     4020

ttatctcaca gttggtgaca gtgcttttga aaggttgcca agatgcaaac tctcaagctc     4080

ggttgctctg tggggaatgt ttaggggaat tgggggcgat agatccaggt cgattagatt     4140

tctcaacaac tgaaactcaa ggaaaagatt ttacatttgt gactggagta gaagattcaa     4200

gctttgccta tggattattg atggagctaa caagagctta ccttgcgtat gctgataata     4260

gccgagctca agattcagct gcctatgcca ttcaggagtt gctttctatt tatgactgta     4320

gagagatgga gaccaacggc ccaggtcacc aattgtggag gagatttcct gagcatgttc     4380

gggaaatact agaacctcat ctaaatacca gatacaagag ttctcagaag tcaaccgatt     4440

ggtctggagt aaagaagcca atttacttaa gtaaattggg tagtaacttt gcagaatggt     4500

cagcatcttg ggcaggttat cttattacaa aggttcgaca tgatcttgcc agtaaaattt     4560

tcacctgctg tagcattatg atgaagcatg atttcaaagt gaccatctat cttcttccac     4620

atattctggt gtatgtctta ctgggttgta atcaagaaga tcagcaggag gtttatgcag     4680

aaattatggc agttctaaag catgacgatc agcataccat aaatacccaa gacattgcat     4740

ctgatctgtg tcaactcagt acacagactg tgttctccat gcttgaccat ctcacacagt     4800

gggcaaggca caaatttcag gcactgaaag ctgagaaatg tccacacagc aaatcaaaca     4860

gaaataaggt agactcaatg gtatctactg tggattatga agactatcag agtgtaaccc     4920

gttttctaga cctcataccc caggatactc tggcagtagc ttcctttcgc tccaaagcat     4980

acacacgagc tgtaatgcac tttgaatcat ttattacaga aaagaagcaa aatattcagg     5040

aacatcttgg atttttacag aaattgtatg ctgctatgca tgaacctgat ggagtggccg     5100

gagtcagtgc aattagaaag gcagaaccat ctctaaaaga acagatcctt gaacatgaaa     5160

gccttggctt gctgagggat gccactgctt gttatgacag ggctattcag ctagaaccag     5220

accagatcat tcattatcat ggtgtagtaa agtccatgtt aggtcttggt cagctgtcta     5280

ctgttatcac tcaggtgaat ggagtgcatg ctaacaggtc cgagtggaca gatgaattaa     5340

acacgtacag agtggaagca gcttggaaat tgtcacagtg ggatttggtg gaaaactatt     5400

tggcagcaga tggaaaatct acaacatgga gtgtcagact gggacagcta ttattatcag     5460

ccaaaaaaag agatatcaca gctttttatg actcactgaa actagtgaga gcagaacaaa     5520

ttgtacctct ttcagctgca agctttgaaa gaggctccta ccaacgagga tatgaatata     5580

ttgtgagatt gcacatgtta tgtgagttgg agcatagcat caaaccactt ttccagcatt     5640

ctccaggtga cagttctcaa gaagattctc taaactgggt agctcgacta gaaatgaccc     5700

agaattccta cagagccaag gagcctatcc tggctctccg gagggcttta ctaagcctca     5760

acaaaagacc agattacaat gaaatggttg gagaatgctg gctgcagagt gccagggtag     5820

ctagaaaggc tggtcaccac cagacagcct acaatgctct ccttaatgca ggggaatcac     5880

gactcgctga actgtacgtg gaaagggcaa agtggctctg gtccaagggt gatgttcacc     5940

aggcactaat tgttcttcaa aaaggtgttg aattatgttt tcctgaaaat gaaaccccac     6000

ctgagggtaa gaacatgtta atccatggtc gagctatgct actagtgggc cgatttatgg     6060

aagaaacagc taactttgaa agcaatgcaa ttatgaaaaa atataaggat gtgaccgcgt     6120

gcctgccaga atgggaggat gggcattttt accttgccaa gtactatgac aaattgatgc     6180

ccatggtcac agacaacaaa atggaaaagc aaggtgatct catccggtat atagttcttc     6240

attttggcag atctctacaa tatggaaatc agttcatata tcagtcaatg ccacgaatgt     6300

taactctatg gcttgattat ggtacaaagg catatgaatg ggaaaaagct ggccgctccg     6360

atcgtgtaca aatgaggaat gatttgggta aaataaacaa ggttatcaca gagcatacaa     6420

actatttagc tccatatcaa tttttgactg ctttttcaca attgatctct cgaatttgtc     6480

attctcacga tgaagttttt gttgtcttga tggaaataat agccaaagta tttctagcct     6540

atcctcaaca agcaatgtgg atgatgacag ctgtgtcaaa gtcatcttat cccatgcgtg     6600

tgaacagatg caaggaaatc ctcaataaag ctattcatat gaaaaaatcc ttagagaagt     6660

ttgttggaga tgcaactcgc ctaacagata agcttctaga attgtgcaat aaaccggttg     6720

atggaagtag ttccacatta agcatgagca ctcattttaa aatgcttaaa aagctggtag     6780

aagaagcaac atttagtgaa atcctcattc ctctacaatc agtcatgata cctacacttc     6840

catcaattct gggtacccat gctaaccatg ctagccatga accatttcct ggacattggg     6900

cctatattgc agggtttgat gatatggtgg aaattcttgc ttctcttcag aaaccaaaga     6960

agatttcttt aaaaggctca gatggaaagt tctacatcat gatgtgtaag ccaaaagatg     7020

acctgagaaa ggattgtaga ctaatggaat tcaattcctt gattaataag tgcttaagaa     7080

aagatgcaga gtctcgtaga agagaacttc atattcgaac atatgcagtt attccactaa     7140

atgatgaatg tgggattatt gaatgggtga acaacactgc tggtttgaga cctattctga     7200

ccaaactata taaagaaaag ggagtgtata tgacaggaaa agaacttcgc cagtgtatgc     7260

taccaaagtc agcagcttta tctgaaaaac tcaaagtatt ccgagaattt ctcctgccca     7320

ggcatcctcc tatttttcat gagtggtttc tgagaacatt ccctgatcct acatcatggt     7380

acagtagtag atcagcttac tgccgttcca ctgcagtaat gtcaatggtt ggttatattc     7440

tggggcttgg agaccgtcat ggtgaaaata ttctctttga ttctttgact ggtgaatgcg     7500

tacatgtaga tttcaattgt cttttcaata agggagaaac ctttgaagtt ccagaaattg     7560

tgccatttcg cctgactcat aatatggtta atggaatggg tcctatggga acagagggtc     7620

tttttcgaag agcatgtgaa gttacaatga ggctgatgcg tgatcagcga gagcctttaa     7680

tgagtgtctt aaagactttt ctacatgatc ctcttgtgga atggagtaaa ccagtgaaag     7740

ggcattccaa agcgccactg aatgaaactg gagaagttgt caatgaaaag gccaagaccc     7800

atgttcttga cattgagcag cgactacaag gtgtaatcaa gactcgaaat agagtgacag     7860

gactgccgtt atctattgaa ggacatgtgc attaccttat acaggaagct actgatgaaa     7920

acttactatg ccagatgtat cttggttgga ctccatatat gtgaaatgaa attatgtaaa     7980

agaatatgtt aataatctaa aagtaatgca tttggtatga atctgtggtt gtatctgttc     8040

aattctaaag tacaacataa atttacgttc tcagcaactg ttatttctct ctgatcatta     8100

attatatgta aaataatata cattcagtta ttaagaaata aactgctttc ttaataca       8158


