                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  THERAPEUTIC PEPTIDE FORMULATIONS

<130>  X22102

<150>  US 63/129,157
<151>  2020-12-22

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys at position 20 is chemically modified by conjugation of the 
       epsilon-amino group of the Lys side chain with 
       ([2-(2-aminoethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)18CO2H

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  Gly at position 34 is amidated

<400>  1

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Lys Ala Lys Glu Phe Val Glu Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly 
        


<210>  2
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys at position 20 is chemically modified by conjugation of the 
       epsilon-amino group of the Lys side chain with 
       ([2-(2-aminoethoxy)-ethoxy]-acetyl)2-(gamma-Glu)2-CO-(CH2)18CO2H

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  Gly at position 34 is amidated

<400>  2

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Lys Ala Lys Glu Phe Val Glu Trp Leu Leu Ser Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly 
        


<210>  3
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys at position 20 is chemically modified by conjugation of the 
       epsilon-amino group of the Lys side chain with 
       ([2-(2-aminoethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)16CO2H

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  Gly at position 34 is amidated

<400>  3

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Lys Ala Lys Glu Phe Val Glu Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly 
        


<210>  4
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys at position 20 is chemically modified by conjugation of the 
       epsilon-amino group of the Lys side chain with 
       ([2-(2-aminoethoxy)-ethoxy]-acetyl)2-(gamma-Glu)2-CO-(CH2)16CO2H

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  Gly at position 34 is amidated

<400>  4

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Lys Ala Lys Glu Phe Val Glu Trp Leu Leu Ser Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly 
        


<210>  5
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys at position 20 is chemically modified by conjugation of the 
       epsilon-amino group of the Lys side chain with a C14-C24 fatty 
       acid via a linker, wherein the linker is 
       ([2-(2-aminoethoxy)-ethoxy]-acetyl)2-(gamma-Glu)t, wherein t is 1
       

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is Glu or Ser

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  Gly at position 34 is optionally amidated

<400>  5

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Lys Ala Lys Glu Phe Val Glu Trp Leu Leu Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly 
        


