                               SEQUENCE LISTING

<110> EMPIRICO INC.
 
<120> GALNAC COMPOSITIONS FOR IMPROVING SIRNA BIOAVAILABILITY

<130> 54462-723.601

<140>
<141>

<150> 63/129,126
<151> 2020-12-22

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 1
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 2
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 2
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 3
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 3
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 4
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220> 
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 4
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 5
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 5
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 6
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 6
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 7
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, u, g, unknown or other

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 7
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210> 8
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, u, g, unknown or other

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 8
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210> 9
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, u, g, unknown or other

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 9
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210> 10
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, u, g, unknown or other

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 10
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210> 11
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 11
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 12
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (3)..(3)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 12
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 13
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 13
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 14
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 14
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 15
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220> 
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 15
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 16
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 16
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 17
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 17
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 18
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 18
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 19
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 19
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 20
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 20
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 21
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 21
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (4)..(5)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (7)..(7)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (8)..(8)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (9)..(9)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (9)..(10)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (10)..(10)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (11)..(11)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (11)..(12)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (12)..(12)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (12)..(13)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (13)..(13)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (13)..(14)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (14)..(15)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (15)..(15)
<223> Any deoxynucleotide

<220>
<221> misc_feature
<222> (15)..(16)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (16)..(17)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (17)..(18)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 22
nnnnnnnnnn nnnnnnnnnn                                                   20


<210> 23
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
ggacaauacu uccacucua                                                    19


<210> 24
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 24
ggacaauacu uccacucuau u                                                 21


<210> 25
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 25
ggacaauacu uccacucuau u                                                 21


<210> 26
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 26
ggacaauacu uccacucuau u                                                 21


<210> 27
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
uagaguggaa guauugucc                                                    19


<210> 28
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2' fluoro-modified nucleoside

<220>
<221> misc_feature
<222> (2)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (6)..(6)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (14)..(14)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (16)..(16)
<223> 2' fluoro-modified nucleoside

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (19)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'O-methyl or 2'O-methoxyethyl-modified nucleoside

<400> 28
uagaguggaa guauuguccu u                                                 21


