                         SEQUENCE LISTING

<110>  Ludwig Institute for Cancer Research Ltd.
       Centre Hospitalier Universitaire Vaudois
       University of Lausanne
 
<120>  GENETICALLY ENGINEERED LYMPHOCYTES FOR ADOPTIVE CELL THERAPY

<130>  084276.00319

<150>  63/199,376
<151>  2020-12-22

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Thr Gln Lys Val Thr Pro Ala Leu Ile Phe Ala Ile Thr Val 
1               5                   10                  15      


Ala Thr Ile Gly Ser Phe Gln Phe Gly Tyr Asn Thr Gly Val Ile Asn 
            20                  25                  30          


Ala Pro Glu Lys Ile Ile Lys Glu Phe Ile Asn Lys Thr Leu Thr Asp 
        35                  40                  45              


Lys Gly Asn Ala Pro Pro Ser Glu Val Leu Leu Thr Ser Leu Trp Ser 
    50                  55                  60                  


Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser Phe Ser 
65                  70                  75                  80  


Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met Leu Ile 
                85                  90                  95      


Val Asn Leu Leu Ala Val Thr Gly Gly Cys Phe Met Gly Leu Cys Lys 
            100                 105                 110         


Val Ala Lys Ser Val Glu Met Leu Ile Leu Gly Arg Leu Val Ile Gly 
        115                 120                 125             


Leu Phe Cys Gly Leu Cys Thr Gly Phe Val Pro Met Tyr Ile Gly Glu 
    130                 135                 140                 


Ile Ser Pro Thr Ala Leu Arg Gly Ala Phe Gly Thr Leu Asn Gln Leu 
145                 150                 155                 160 


Gly Ile Val Val Gly Ile Leu Val Ala Gln Ile Phe Gly Leu Glu Phe 
                165                 170                 175     


Ile Leu Gly Ser Glu Glu Leu Trp Pro Leu Leu Leu Gly Phe Thr Ile 
            180                 185                 190         


Leu Pro Ala Ile Leu Gln Ser Ala Ala Leu Pro Phe Cys Pro Glu Ser 
        195                 200                 205             


Pro Arg Phe Leu Leu Ile Asn Arg Lys Glu Glu Glu Asn Ala Lys Gln 
    210                 215                 220                 


Ile Leu Gln Arg Leu Trp Gly Thr Gln Asp Val Ser Gln Asp Ile Gln 
225                 230                 235                 240 


Glu Met Lys Asp Glu Ser Ala Arg Met Ser Gln Glu Lys Gln Val Thr 
                245                 250                 255     


Val Leu Glu Leu Phe Arg Val Ser Ser Tyr Arg Gln Pro Ile Ile Ile 
            260                 265                 270         


Ser Ile Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn Ala Val 
        275                 280                 285             


Phe Tyr Tyr Ser Thr Gly Ile Phe Lys Asp Ala Gly Val Gln Glu Pro 
    290                 295                 300                 


Ile Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Ile Phe Thr Val 
305                 310                 315                 320 


Val Ser Leu Phe Leu Val Glu Arg Ala Gly Arg Arg Thr Leu His Met 
                325                 330                 335     


Ile Gly Leu Gly Gly Met Ala Phe Cys Ser Thr Leu Met Thr Val Ser 
            340                 345                 350         


Leu Leu Leu Lys Asp Asn Tyr Asn Gly Met Ser Phe Val Cys Ile Gly 
        355                 360                 365             


Ala Ile Leu Val Phe Val Ala Phe Phe Glu Ile Gly Pro Gly Pro Ile 
    370                 375                 380                 


Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg Pro Ala 
385                 390                 395                 400 


Ala Met Ala Val Ala Gly Cys Ser Asn Trp Thr Ser Asn Phe Leu Val 
                405                 410                 415     


Gly Leu Leu Phe Pro Ser Ala Ala His Tyr Leu Gly Ala Tyr Val Phe 
            420                 425                 430         


Ile Ile Phe Thr Gly Phe Leu Ile Thr Phe Leu Ala Phe Thr Phe Phe 
        435                 440                 445             


Lys Val Pro Glu Thr Arg Gly Arg Thr Phe Glu Asp Ile Thr Arg Ala 
    450                 455                 460                 


Phe Glu Gly Gln Ala His Gly Ala Asp Arg Ser Gly Lys Asp Gly Val 
465                 470                 475                 480 


Met Glu Met Asn Ser Ile Glu Pro Ala Lys Glu Thr Thr Thr Asn Val 
                485                 490                 495     


<210>  2
<211>  493
<212>  PRT
<213>  Mus musculus

<400>  2

Met Gly Thr Thr Lys Val Thr Pro Ser Leu Val Phe Ala Val Thr Val 
1               5                   10                  15      


Ala Thr Ile Gly Ser Phe Gln Phe Gly Tyr Asn Thr Gly Val Ile Asn 
            20                  25                  30          


Ala Pro Glu Thr Ile Leu Lys Asp Phe Leu Asn Tyr Thr Leu Glu Glu 
        35                  40                  45              


Arg Leu Glu Asp Leu Pro Ser Glu Gly Leu Leu Thr Ala Leu Trp Ser 
    50                  55                  60                  


Leu Cys Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser Phe Ser 
65                  70                  75                  80  


Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met Leu Leu 
                85                  90                  95      


Val Asn Leu Leu Ala Ile Ile Ala Gly Cys Leu Met Gly Phe Ala Lys 
            100                 105                 110         


Ile Ala Glu Ser Val Glu Met Leu Ile Leu Gly Arg Leu Leu Ile Gly 
        115                 120                 125             


Ile Phe Cys Gly Leu Cys Thr Gly Phe Val Pro Met Tyr Ile Gly Glu 
    130                 135                 140                 


Val Ser Pro Thr Ala Leu Arg Gly Ala Phe Gly Thr Leu Asn Gln Leu 
145                 150                 155                 160 


Gly Ile Val Val Gly Ile Leu Val Ala Gln Ile Phe Gly Leu Asp Phe 
                165                 170                 175     


Ile Leu Gly Ser Glu Glu Leu Trp Pro Gly Leu Leu Gly Leu Thr Ile 
            180                 185                 190         


Ile Pro Ala Ile Leu Gln Ser Ala Ala Leu Pro Phe Cys Pro Glu Ser 
        195                 200                 205             


Pro Arg Phe Leu Leu Ile Asn Lys Lys Glu Glu Asp Gln Ala Thr Glu 
    210                 215                 220                 


Ile Leu Gln Arg Leu Trp Gly Thr Ser Asp Val Val Gln Glu Ile Gln 
225                 230                 235                 240 


Glu Met Lys Asp Glu Ser Val Arg Met Ser Gln Glu Lys Gln Val Thr 
                245                 250                 255     


Val Leu Glu Leu Phe Arg Ser Pro Asn Tyr Val Gln Pro Leu Leu Ile 
            260                 265                 270         


Ser Ile Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn Ala Val 
        275                 280                 285             


Phe Tyr Tyr Ser Thr Gly Ile Phe Lys Asp Ala Gly Val Gln Glu Pro 
    290                 295                 300                 


Ile Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Ile Phe Thr Val 
305                 310                 315                 320 


Val Ser Leu Phe Leu Val Glu Arg Ala Gly Arg Arg Thr Leu His Met 
                325                 330                 335     


Ile Gly Leu Gly Gly Met Ala Val Cys Ser Val Phe Met Thr Ile Ser 
            340                 345                 350         


Leu Leu Leu Lys Asp Asp Tyr Glu Ala Met Ser Phe Val Cys Ile Val 
        355                 360                 365             


Ala Ile Leu Ile Tyr Val Ala Phe Phe Glu Ile Gly Pro Gly Pro Ile 
    370                 375                 380                 


Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg Pro Ala 
385                 390                 395                 400 


Ala Ile Ala Val Ala Gly Cys Cys Asn Trp Thr Ser Asn Phe Leu Val 
                405                 410                 415     


Gly Met Leu Phe Pro Ser Ala Ala Ala Tyr Leu Gly Ala Tyr Val Phe 
            420                 425                 430         


Ile Ile Phe Ala Ala Phe Leu Ile Phe Phe Leu Ile Phe Thr Phe Phe 
        435                 440                 445             


Lys Val Pro Glu Thr Lys Gly Arg Thr Phe Glu Asp Ile Ala Arg Ala 
    450                 455                 460                 


Phe Glu Gly Gln Ala His Ser Gly Lys Gly Pro Ala Gly Val Glu Leu 
465                 470                 475                 480 


Asn Ser Met Gln Pro Val Lys Glu Thr Pro Gly Asn Ala 
                485                 490             


<210>  3
<211>  493
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Gly Thr Ala Lys Val Thr Pro Ser Leu Val Phe Ala Val Thr Val 
1               5                   10                  15      


Ala Thr Ile Gly Ser Phe Gln Phe Gly Tyr Asn Thr Gly Val Ile Asn 
            20                  25                  30          


Ala Pro Glu Thr Ile Ile Lys Asp Phe Leu Asn Tyr Thr Leu Glu Glu 
        35                  40                  45              


Arg Leu Glu Asp Leu Pro Ser Glu Gly Leu Leu Thr Thr Leu Trp Ser 
    50                  55                  60                  


Leu Cys Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser Phe Ser 
65                  70                  75                  80  


Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met Leu Leu 
                85                  90                  95      


Val Asn Leu Ile Ala Ile Leu Gly Gly Cys Leu Met Gly Phe Ala Lys 
            100                 105                 110         


Ile Ala Glu Ser Val Glu Met Leu Ile Leu Gly Arg Leu Ile Ile Gly 
        115                 120                 125             


Ile Phe Cys Gly Leu Cys Thr Gly Phe Val Pro Met Tyr Ile Gly Glu 
    130                 135                 140                 


Val Ser Pro Thr Ala Leu Arg Gly Ala Phe Gly Thr Leu Asn Gln Leu 
145                 150                 155                 160 


Gly Ile Val Val Gly Ile Leu Val Ala Gln Val Phe Gly Leu Asp Phe 
                165                 170                 175     


Ile Leu Gly Ser Glu Glu Leu Trp Pro Gly Leu Leu Gly Leu Thr Ile 
            180                 185                 190         


Ile Pro Ala Ile Leu Gln Ser Ala Ala Leu Pro Phe Cys Pro Glu Ser 
        195                 200                 205             


Pro Arg Phe Leu Leu Ile Asn Arg Lys Glu Glu Asp Gln Ala Thr Glu 
    210                 215                 220                 


Ile Leu Gln Arg Leu Trp Gly Thr Pro Asp Val Ile Gln Glu Ile Gln 
225                 230                 235                 240 


Glu Met Lys Asp Glu Ser Ile Arg Met Ser Gln Glu Lys Gln Val Thr 
                245                 250                 255     


Val Leu Glu Leu Phe Lys Ser Pro Ser Tyr Phe Gln Pro Leu Leu Ile 
            260                 265                 270         


Ser Val Val Leu Gln Leu Ser Gln Gln Phe Ser Gly Ile Asn Ala Val 
        275                 280                 285             


Phe Tyr Tyr Ser Thr Gly Ile Phe Gln Asp Ala Gly Val Gln Glu Pro 
    290                 295                 300                 


Ile Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Ile Phe Thr Val 
305                 310                 315                 320 


Val Ser Leu Phe Leu Val Glu Arg Ala Gly Arg Arg Thr Leu His Met 
                325                 330                 335     


Ile Gly Leu Gly Gly Met Ala Val Cys Ser Val Phe Met Thr Ile Ser 
            340                 345                 350         


Leu Leu Leu Lys Asp Glu Tyr Glu Ala Met Ser Phe Val Cys Ile Val 
        355                 360                 365             


Ala Ile Leu Val Tyr Val Ala Phe Phe Glu Ile Gly Pro Gly Pro Ile 
    370                 375                 380                 


Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg Pro Ala 
385                 390                 395                 400 


Ala Met Ala Val Ala Gly Cys Ser Asn Trp Thr Ser Asn Phe Leu Val 
                405                 410                 415     


Gly Met Phe Phe Pro Ser Ala Ala Ala Tyr Leu Gly Ala Tyr Val Phe 
            420                 425                 430         


Ile Ile Phe Ala Ala Phe Leu Val Phe Phe Leu Ile Phe Thr Phe Phe 
        435                 440                 445             


Lys Val Pro Glu Thr Lys Gly Arg Thr Phe Glu Asp Ile Thr Arg Ala 
    450                 455                 460                 


Phe Glu Gly Gln Ala Gln Ser Gly Lys Gly Ser Ala Gly Val Glu Leu 
465                 470                 475                 480 


Asn Ser Met Gln Pro Val Lys Glu Thr Pro Gly Asn Ala 
                485                 490             


<210>  4
<211>  493
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Gly Thr Ala Lys Val Thr Pro Ser Leu Val Phe Ala Val Thr Val 
1               5                   10                  15      


Ala Thr Ile Gly Ser Phe Gln Phe Gly Tyr Asn Thr Gly Val Ile Asn 
            20                  25                  30          


Ala Pro Glu Thr Ile Ile Lys Asp Phe Leu Asn Tyr Thr Leu Glu Glu 
        35                  40                  45              


Arg Leu Glu Asp Leu Pro Arg Glu Gly Leu Leu Thr Thr Leu Trp Ser 
    50                  55                  60                  


Leu Cys Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser Phe Ser 
65                  70                  75                  80  


Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met Leu Leu 
                85                  90                  95      


Val Asn Leu Ile Ala Ile Leu Gly Gly Cys Leu Met Gly Phe Ala Lys 
            100                 105                 110         


Ile Ala Glu Ser Val Glu Met Leu Ile Leu Gly Arg Leu Ile Ile Gly 
        115                 120                 125             


Ile Phe Cys Gly Leu Cys Thr Gly Phe Val Pro Met Tyr Ile Gly Glu 
    130                 135                 140                 


Val Ser Pro Thr Ala Leu Arg Gly Ala Phe Gly Thr Leu Asn Gln Leu 
145                 150                 155                 160 


Gly Ile Val Val Gly Ile Leu Val Ala Gln Val Phe Gly Leu Asp Phe 
                165                 170                 175     


Ile Leu Gly Ser Glu Glu Leu Trp Pro Gly Leu Leu Gly Leu Thr Ile 
            180                 185                 190         


Ile Pro Ala Ile Leu Gln Ser Ala Ala Leu Pro Phe Cys Pro Glu Ser 
        195                 200                 205             


Pro Arg Phe Leu Leu Ile Asn Arg Lys Glu Glu Asp Gln Ala Thr Glu 
    210                 215                 220                 


Ile Leu Gln Arg Leu Trp Gly Thr Pro Asp Val Ile Gln Glu Ile Gln 
225                 230                 235                 240 


Glu Met Lys Asp Glu Ser Ile Arg Met Ser Gln Glu Lys Gln Val Thr 
                245                 250                 255     


Val Leu Glu Leu Phe Lys Ser Pro Ser Tyr Phe Gln Pro Leu Leu Ile 
            260                 265                 270         


Ser Val Val Leu Gln Leu Ser Gln Gln Phe Ser Gly Ile Asn Ala Val 
        275                 280                 285             


Phe Tyr Tyr Ser Thr Gly Ile Phe Gln Asp Ala Gly Val Gln Glu Pro 
    290                 295                 300                 


Ile Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Ile Phe Thr Val 
305                 310                 315                 320 


Val Ser Leu Phe Leu Val Glu Arg Ala Gly Arg Arg Thr Leu His Met 
                325                 330                 335     


Ile Gly Leu Gly Gly Met Ala Val Cys Ser Val Phe Met Thr Ile Ser 
            340                 345                 350         


Leu Leu Leu Lys Asp Glu Tyr Glu Ala Met Ser Phe Val Cys Ile Val 
        355                 360                 365             


Ala Ile Leu Val Tyr Val Ala Phe Phe Glu Ile Gly Pro Gly Pro Ile 
    370                 375                 380                 


Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg Pro Ala 
385                 390                 395                 400 


Ala Met Ala Val Ala Gly Cys Ser Asn Trp Thr Ser Asn Phe Leu Val 
                405                 410                 415     


Gly Met Phe Phe Pro Ser Ala Ala Ala Tyr Leu Gly Ala Tyr Val Phe 
            420                 425                 430         


Ile Ile Phe Ala Ala Phe Leu Val Phe Phe Leu Ile Phe Thr Ser Phe 
        435                 440                 445             


Lys Val Pro Glu Thr Lys Gly Arg Thr Phe Glu Asp Ile Thr Arg Ala 
    450                 455                 460                 


Phe Glu Gly Gln Ala His Ser Gly Lys Gly Ser Ala Gly Val Glu Leu 
465                 470                 475                 480 


Asn Ser Met Gln Pro Val Lys Glu Thr Pro Gly Asn Ala 
                485                 490             


<210>  5
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Ala Asp Pro Pro Arg Asp Ser Lys Gly Leu Ala Ala Ala Glu 
1               5                   10                  15      


Pro Thr Ala Asn Gly Gly Leu Ala Leu Ala Ser Ile Glu Asp Gln Gly 
            20                  25                  30          


Ala Ala Ala Gly Gly Tyr Cys Gly Ser Arg Asp Gln Val Arg Arg Cys 
        35                  40                  45              


Leu Arg Ala Asn Leu Leu Val Leu Leu Thr Val Val Ala Val Val Ala 
    50                  55                  60                  


Gly Val Ala Leu Gly Leu Gly Val Ser Gly Ala Gly Gly Ala Leu Ala 
65                  70                  75                  80  


Leu Gly Pro Glu Arg Leu Ser Ala Phe Val Phe Pro Gly Glu Leu Leu 
                85                  90                  95      


Leu Arg Leu Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys Ser Leu 
            100                 105                 110         


Ile Gly Gly Ala Ala Ser Leu Asp Pro Gly Ala Leu Gly Arg Leu Gly 
        115                 120                 125             


Ala Trp Ala Leu Leu Phe Phe Leu Val Thr Thr Leu Leu Ala Ser Ala 
    130                 135                 140                 


Leu Gly Val Gly Leu Ala Leu Ala Leu Gln Pro Gly Ala Ala Ser Ala 
145                 150                 155                 160 


Ala Ile Asn Ala Ser Val Gly Ala Ala Gly Ser Ala Glu Asn Ala Pro 
                165                 170                 175     


Ser Lys Glu Val Leu Asp Ser Phe Leu Asp Leu Ala Arg Asn Ile Phe 
            180                 185                 190         


Pro Ser Asn Leu Val Ser Ala Ala Phe Arg Ser Tyr Ser Thr Thr Tyr 
        195                 200                 205             


Glu Glu Arg Asn Ile Thr Gly Thr Arg Val Lys Val Pro Val Gly Gln 
    210                 215                 220                 


Glu Val Glu Gly Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val 
225                 230                 235                 240 


Phe Gly Val Ala Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile 
                245                 250                 255     


Arg Phe Phe Asn Ser Phe Asn Glu Ala Thr Met Val Leu Val Ser Trp 
            260                 265                 270         


Ile Met Trp Tyr Ala Pro Val Gly Ile Met Phe Leu Val Ala Gly Lys 
        275                 280                 285             


Ile Val Glu Met Glu Asp Val Gly Leu Leu Phe Ala Arg Leu Gly Lys 
    290                 295                 300                 


Tyr Ile Leu Cys Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val 
305                 310                 315                 320 


Leu Pro Leu Ile Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe 
                325                 330                 335     


Leu Trp Gly Ile Val Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser 
            340                 345                 350         


Ser Ser Ala Thr Leu Pro Leu Met Met Lys Cys Val Glu Glu Asn Asn 
        355                 360                 365             


Gly Val Ala Lys His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr 
    370                 375                 380                 


Val Asn Met Asp Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe 
385                 390                 395                 400 


Ile Ala Gln Leu Ser Gln Gln Ser Leu Asp Phe Val Lys Ile Ile Thr 
                405                 410                 415     


Ile Leu Val Thr Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro 
            420                 425                 430         


Ala Gly Gly Val Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Asn Leu 
        435                 440                 445             


Pro Val Asp His Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp 
    450                 455                 460                 


Arg Ser Cys Thr Val Leu Asn Val Glu Gly Asp Ala Leu Gly Ala Gly 
465                 470                 475                 480 


Leu Leu Gln Asn Tyr Val Asp Arg Thr Glu Ser Arg Ser Thr Glu Pro 
                485                 490                 495     


Glu Leu Ile Gln Val Lys Ser Glu Leu Pro Leu Asp Pro Leu Pro Val 
            500                 505                 510         


Pro Thr Glu Glu Gly Asn Pro Leu Leu Lys His Tyr Arg Gly Pro Ala 
        515                 520                 525             


Gly Asp Ala Thr Val Ala Ser Glu Lys Glu Ser Val Met 
    530                 535                 540     


<210>  6
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val Phe Gly Val Ala 
1               5                   10                  15      


Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile Arg Phe Phe Asn 
            20                  25                  30          


Ser Phe Asn Glu Ala Thr Met Val Leu Val Ser Trp Ile Met Trp Tyr 
        35                  40                  45              


Ala Pro Val Gly Ile Met Phe Leu Val Ala Gly Lys Ile Val Glu Met 
    50                  55                  60                  


Glu Asp Val Gly Leu Leu Phe Ala Arg Leu Gly Lys Tyr Ile Leu Cys 
65                  70                  75                  80  


Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val Leu Pro Leu Ile 
                85                  90                  95      


Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe Leu Trp Gly Ile 
            100                 105                 110         


Val Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser Ser Ser Ala Thr 
        115                 120                 125             


Leu Pro Leu Met Met Lys Cys Val Glu Glu Asn Asn Gly Val Ala Lys 
    130                 135                 140                 


His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr Val Asn Met Asp 
145                 150                 155                 160 


Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe Ile Ala Gln Leu 
                165                 170                 175     


Ser Gln Gln Ser Leu Asp Phe Val Lys Ile Ile Thr Ile Leu Val Thr 
            180                 185                 190         


Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro Ala Gly Gly Val 
        195                 200                 205             


Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Asn Leu Pro Val Asp His 
    210                 215                 220                 


Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp Arg Ser Cys Thr 
225                 230                 235                 240 


Val Leu Asn Val Glu Gly Asp Ala Leu Gly Ala Gly Leu Leu Gln Asn 
                245                 250                 255     


Tyr Val Asp Arg Thr Glu Ser Arg Ser Thr Glu Pro Glu Leu Ile Gln 
            260                 265                 270         


Val Lys Ser Glu Leu Pro Leu Asp Pro Leu Pro Val Pro Thr Glu Glu 
        275                 280                 285             


Gly Asn Pro Leu Leu Lys His Tyr Arg Gly Pro Ala Gly Asp Ala Thr 
    290                 295                 300                 


Val Ala Ser Glu Lys Glu Ser Val Met 
305                 310             


<210>  7
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Tyr Ser Thr Thr Tyr Glu Glu Arg Asn Ile Thr Gly Thr Arg Val 
1               5                   10                  15      


Lys Val Pro Val Gly Gln Glu Val Glu Gly Met Asn Ile Leu Gly Leu 
            20                  25                  30          


Val Val Phe Ala Ile Val Phe Gly Val Ala Leu Arg Lys Leu Gly Pro 
        35                  40                  45              


Glu Gly Glu Leu Leu Ile Arg Phe Phe Asn Ser Phe Asn Glu Ala Thr 
    50                  55                  60                  


Met Val Leu Val Ser Trp Ile Met Trp Tyr Ala Pro Val Gly Ile Met 
65                  70                  75                  80  


Phe Leu Val Ala Gly Lys Ile Val Glu Met Glu Asp Val Gly Leu Leu 
                85                  90                  95      


Phe Ala Arg Leu Gly Lys Tyr Ile Leu Cys Cys Leu Leu Gly His Ala 
            100                 105                 110         


Ile His Gly Leu Leu Val Leu Pro Leu Ile Tyr Phe Leu Phe Thr Arg 
        115                 120                 125             


Lys Asn Pro Tyr Arg Phe Leu Trp Gly Ile Val Thr Pro Leu Ala Thr 
    130                 135                 140                 


Ala Phe Gly Thr Ser Ser Ser Ser Ala Thr Leu Pro Leu Met Met Lys 
145                 150                 155                 160 


Cys Val Glu Glu Asn Asn Gly Val Ala Lys His Ile Ser Arg Phe Ile 
                165                 170                 175     


Leu Pro Ile Gly Ala Thr Val Asn Met Asp Gly Ala Ala Leu Phe Gln 
            180                 185                 190         


Cys Val Ala Ala Val Phe Ile Ala Gln Leu Ser Gln Gln Ser Leu Asp 
        195                 200                 205             


Phe Val Lys Ile Ile Thr Ile Leu Val Thr Ala Thr Ala Ser Ser Val 
    210                 215                 220                 


Gly Ala Ala Gly Ile Pro Ala Gly Gly Val Leu Thr Leu Ala Ile Ile 
225                 230                 235                 240 


Leu Glu Ala Val Asn Leu Pro Val Asp His Ile Ser Leu Ile Leu Ala 
                245                 250                 255     


Val Asp Trp Leu Val Asp Arg Ser Cys Thr Val Leu Asn Val Glu Gly 
            260                 265                 270         


Asp Ala Leu Gly Ala Gly Leu Leu Gln Asn Tyr Val Asp Arg Thr Glu 
        275                 280                 285             


Ser Arg Ser Thr Glu Pro Glu Leu Ile Gln Val Lys Ser Glu Leu Pro 
    290                 295                 300                 


Leu Asp Pro Leu Pro Val Pro Thr Glu Glu Gly Asn Pro Leu Leu Lys 
305                 310                 315                 320 


His Tyr Arg Gly Pro Ala Gly Asp Ala Thr Val Ala Ser Glu Lys Glu 
                325                 330                 335     


Ser Val Met 
            


<210>  8
<211>  555
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ala Val Asp Pro Pro Lys Ala Asp Pro Lys Gly Val Val Ala Val 
1               5                   10                  15      


Asp Ser Thr Ala Asn Gly Gly Pro Ala Leu Gly Ser Arg Glu Asp Gln 
            20                  25                  30          


Ser Ala Lys Ala Gly Gly Cys Cys Gly Ser Arg Asp Arg Val Arg Arg 
        35                  40                  45              


Cys Ile Arg Ala Asn Leu Leu Val Leu Leu Thr Val Ala Ala Val Val 
    50                  55                  60                  


Ala Gly Val Gly Leu Gly Leu Gly Val Ser Ala Ala Gly Gly Ala Asp 
65                  70                  75                  80  


Ala Leu Gly Pro Ala Arg Leu Thr Ala Phe Ala Phe Pro Gly Glu Leu 
                85                  90                  95      


Leu Leu Arg Leu Leu Lys Met Ile Ile Leu Pro Leu Val Val Cys Ser 
            100                 105                 110         


Leu Ile Gly Gly Ala Ala Ser Leu Asp Pro Ser Ala Leu Gly Arg Val 
        115                 120                 125             


Gly Ala Trp Ala Leu Leu Phe Phe Leu Val Thr Thr Leu Leu Ala Ser 
    130                 135                 140                 


Ala Leu Gly Val Gly Leu Ala Leu Ala Leu Lys Pro Gly Ala Ala Val 
145                 150                 155                 160 


Thr Ala Ile Thr Ser Ile Asn Asp Ser Val Val Asp Pro Cys Ala Arg 
                165                 170                 175     


Ser Ala Pro Thr Lys Glu Val Leu Asp Ser Phe Leu Asp Leu Val Arg 
            180                 185                 190         


Asn Ile Phe Pro Ser Asn Leu Val Ser Ala Ala Phe Arg Ser Phe Ala 
        195                 200                 205             


Thr Ser Tyr Glu Pro Lys Asp Asn Ser Cys Lys Ile Pro Gln Ser Cys 
    210                 215                 220                 


Ile Gln Arg Glu Ile Asn Ser Thr Met Val Gln Leu Leu Cys Glu Val 
225                 230                 235                 240 


Glu Gly Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val Phe Gly 
                245                 250                 255     


Val Ala Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile Arg Phe 
            260                 265                 270         


Phe Asn Ser Phe Asn Asp Ala Thr Met Val Leu Val Ser Trp Ile Met 
        275                 280                 285             


Trp Tyr Ala Pro Val Gly Ile Leu Phe Leu Val Ala Ser Lys Ile Val 
    290                 295                 300                 


Glu Met Lys Asp Val Arg Gln Leu Phe Ile Ser Leu Gly Lys Tyr Ile 
305                 310                 315                 320 


Leu Cys Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val Leu Pro 
                325                 330                 335     


Leu Ile Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe Leu Trp 
            340                 345                 350         


Gly Ile Met Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser Ser Ser 
        355                 360                 365             


Ala Thr Leu Pro Leu Met Met Lys Cys Val Glu Glu Lys Asn Gly Val 
    370                 375                 380                 


Ala Lys His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr Val Asn 
385                 390                 395                 400 


Met Asp Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe Ile Ala 
                405                 410                 415     


Gln Leu Asn Gly Val Ser Leu Asp Phe Val Lys Ile Ile Thr Ile Leu 
            420                 425                 430         


Val Thr Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro Ala Gly 
        435                 440                 445             


Gly Val Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Ser Leu Pro Val 
    450                 455                 460                 


Lys Asp Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp Arg Ser 
465                 470                 475                 480 


Cys Thr Val Leu Asn Val Glu Gly Asp Ala Phe Gly Ala Gly Leu Leu 
                485                 490                 495     


Gln Ser Tyr Val Asp Arg Thr Lys Met Pro Ser Ser Glu Pro Glu Leu 
            500                 505                 510         


Ile Gln Val Lys Asn Glu Val Ser Leu Asn Pro Leu Pro Leu Ala Thr 
        515                 520                 525             


Glu Glu Gly Asn Pro Leu Leu Lys Gln Tyr Gln Gly Pro Thr Gly Asp 
    530                 535                 540                 


Ser Ser Ala Thr Phe Glu Lys Glu Ser Val Met 
545                 550                 555 


<210>  9
<211>  553
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ala Val Asp Pro Pro Lys Ala Asp Pro Lys Gly Val Ala Val Asp 
1               5                   10                  15      


Ser Ser Arg Arg Cys Pro Ala Leu Gly Ser Arg Glu Asp Gln Ser Ala 
            20                  25                  30          


Lys Ala Gly Gly Cys Cys Gly Ser Arg Asp Arg Val Arg Arg Cys Ile 
        35                  40                  45              


Arg Ala Asn Leu Leu Val Leu Leu Thr Val Ala Ala Val Val Ala Gly 
    50                  55                  60                  


Val Gly Leu Gly Leu Gly Val Ser Ala Ala Gly Gly Ala Asp Ala Leu 
65                  70                  75                  80  


Gly Pro Ala Arg Leu Thr Arg Phe Ala Phe Pro Gly Glu Leu Leu Leu 
                85                  90                  95      


Arg Leu Leu Lys Met Ile Ile Leu Pro Leu Val Val Cys Ser Leu Ile 
            100                 105                 110         


Gly Gly Ala Ala Ser Leu Asp Pro Ser Ala Leu Gly Arg Val Gly Ala 
        115                 120                 125             


Trp Ala Leu Leu Phe Phe Leu Val Thr Thr Leu Leu Ala Ser Ala Leu 
    130                 135                 140                 


Gly Val Gly Leu Ala Leu Ala Leu Lys Pro Gly Ala Ala Val Thr Ala 
145                 150                 155                 160 


Ile Thr Ser Ile Asn Asp Ser Val Val Asp Pro Cys Ala Arg Ser Ala 
                165                 170                 175     


Pro Thr Lys Glu Ala Leu Asp Ser Phe Leu Asp Leu Val Arg Asn Ile 
            180                 185                 190         


Phe Pro Ser Asn Leu Val Ser Ala Ala Phe Arg Ser Phe Ala Thr Ser 
        195                 200                 205             


Tyr Glu Pro Lys Asp Asn Ser Cys Lys Ile Pro Gln Ser Cys Ile Gln 
    210                 215                 220                 


Arg Glu Ile Asn Ser Thr Met Val Gln Leu Leu Cys Glu Val Glu Gly 
225                 230                 235                 240 


Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val Phe Gly Val Ala 
                245                 250                 255     


Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile Arg Phe Phe Asn 
            260                 265                 270         


Ser Phe Asn Asp Ala Thr Met Val Leu Val Ser Trp Ile Met Trp Tyr 
        275                 280                 285             


Ala Pro Val Gly Ile Leu Phe Leu Val Ala Ser Lys Ile Val Glu Met 
    290                 295                 300                 


Lys Asp Val Arg Gln Leu Phe Ile Ser Leu Gly Lys Tyr Ile Leu Cys 
305                 310                 315                 320 


Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val Leu Pro Leu Ile 
                325                 330                 335     


Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe Leu Trp Gly Ile 
            340                 345                 350         


Met Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser Ser Ser Ala Thr 
        355                 360                 365             


Leu Pro Leu Met Met Lys Cys Val Glu Glu Lys Asn Gly Val Ala Lys 
    370                 375                 380                 


His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr Val Asn Met Asp 
385                 390                 395                 400 


Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe Ile Ala Gln Leu 
                405                 410                 415     


Asn Gly Val Ser Leu Asp Phe Val Lys Ile Ile Thr Ile Leu Val Thr 
            420                 425                 430         


Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro Ala Gly Gly Val 
        435                 440                 445             


Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Ser Leu Pro Val Lys Asp 
    450                 455                 460                 


Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp Arg Ser Cys Thr 
465                 470                 475                 480 


Val Leu Asn Val Glu Gly Asp Ala Phe Gly Ala Gly Leu Leu Gln Ser 
                485                 490                 495     


Tyr Val Asp Arg Thr Lys Met Pro Ser Ser Glu Pro Glu Leu Ile Gln 
            500                 505                 510         


Val Lys Asn Glu Val Ser Leu Asn Pro Leu Pro Leu Ala Thr Glu Glu 
        515                 520                 525             


Gly Asn Pro Leu Leu Lys Gln Tyr Gln Gly Pro Thr Gly Asp Ser Ser 
    530                 535                 540                 


Ala Thr Phe Glu Lys Glu Ser Val Met 
545                 550             


<210>  10
<211>  539
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met Ala Val Asp Pro Pro Lys Ala Asp Pro Lys Gly Val Val Ala Val 
1               5                   10                  15      


Asp Pro Thr Ala Asn Cys Gly Ser Gly Leu Lys Ser Arg Glu Asp Gln 
            20                  25                  30          


Gly Ala Lys Ala Gly Gly Cys Cys Ser Ser Arg Asp Gln Val Cys Arg 
        35                  40                  45              


Cys Leu Arg Ala Asn Leu Leu Val Leu Leu Thr Val Ala Ala Ala Val 
    50                  55                  60                  


Ala Gly Val Val Leu Gly Leu Gly Val Ser Ala Ala Gly Gly Ala Glu 
65                  70                  75                  80  


Ala Leu Gly His Ala Arg Phe Thr Ala Phe Ala Phe Pro Gly Glu Leu 
                85                  90                  95      


Leu Leu Arg Leu Leu Glu Met Ile Ile Leu Pro Leu Val Val Cys Ser 
            100                 105                 110         


Leu Ile Gly Gly Ala Ala Ser Leu Asp Pro Ser Ala Leu Gly Arg Leu 
        115                 120                 125             


Gly Ala Trp Ala Leu Leu Phe Phe Leu Val Thr Thr Leu Leu Ser Ser 
    130                 135                 140                 


Ala Leu Gly Val Ala Leu Ala Leu Ala Leu Lys Pro Gly Ala Ala Phe 
145                 150                 155                 160 


Ala Ala Ile Asn Ser Ser Val Val Asp Ser Ser Val His Arg Ala Pro 
                165                 170                 175     


Thr Lys Glu Val Leu Asp Ser Phe Leu Glu Leu Leu Arg Asn Met Phe 
            180                 185                 190         


Pro Ser Asn Leu Val Ser Ala Ser Ala Ala Phe Arg Ile Pro Cys Gly 
        195                 200                 205             


Ala Cys Pro Gln Arg Ser Asn Ala Thr Met Asp Gln Pro His Cys Glu 
    210                 215                 220                 


Met Lys Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val Phe Gly 
225                 230                 235                 240 


Val Ala Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile Arg Phe 
                245                 250                 255     


Phe Asn Ser Phe Asn Asp Ala Thr Met Val Leu Val Ser Trp Ile Met 
            260                 265                 270         


Trp Tyr Ala Pro Ile Gly Ile Leu Phe Leu Val Ala Gly Lys Ile Val 
        275                 280                 285             


Glu Met Lys Asp Ile Arg Gln Leu Phe Ile Gly Leu Gly Lys Tyr Ile 
    290                 295                 300                 


Val Cys Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val Leu Pro 
305                 310                 315                 320 


Leu Ile Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe Leu Trp 
                325                 330                 335     


Gly Ile Val Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser Ser Ser 
            340                 345                 350         


Ala Thr Leu Pro Leu Met Met Lys Cys Val Glu Glu Lys Asn Gly Val 
        355                 360                 365             


Ala Lys His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr Val Asn 
    370                 375                 380                 


Met Asp Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe Ile Ala 
385                 390                 395                 400 


Gln Leu Asn Gly Met Ser Leu Asp Phe Val Lys Ile Ile Thr Ile Leu 
                405                 410                 415     


Val Thr Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro Ala Gly 
            420                 425                 430         


Gly Val Leu Thr Leu Ala Ile Ile Leu Glu Ala Ile Ser Leu Pro Val 
        435                 440                 445             


Lys Asp Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp Arg Ser 
    450                 455                 460                 


Cys Thr Val Leu Asn Val Glu Gly Asp Ala Phe Gly Ala Gly Leu Leu 
465                 470                 475                 480 


Gln Ser Tyr Val Asp Arg Thr Lys Met Pro Ser Ser Glu Pro Glu Leu 
                485                 490                 495     


Ile Gln Val Lys Asn Asp Val Ser Leu Lys Pro Leu Pro Leu Ala Thr 
            500                 505                 510         


Glu Glu Gly Asn Pro Leu Leu Lys Gln Cys Arg Glu Pro Ser Gly Asp 
        515                 520                 525             


Ser Ser Ala Thr Cys Glu Lys Glu Ser Val Met 
    530                 535                 


<210>  11
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
145                 150                 155                 160 


Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro 
                165                 170                 175     


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
            180                 185                 190         


Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
        195                 200                 205             


Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala 
    210                 215                 220                 


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
225                 230                 235                 240 


Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys 
                245                 250                 255     


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
            260                 265                 270         


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser 
        275                 280                 285             


Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln 
    290                 295                 300                 


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
305                 310                 315                 320 


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
                325                 330                 335     


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
            340                 345                 350         


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
        355                 360                 365             


Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile 
    370                 375                 380                 


Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe 
385                 390                 395                 400 


Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile 
                405                 410                 415     


Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
            420                 425                 430         


Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
        435                 440                 445             


Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg 
    450                 455                 460                 


Lys Leu Ser Phe Asp Phe Gln 
465                 470     


<210>  12
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp 
1               5                   10                  15      


Tyr Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His 
            20                  25                  30          


Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr 
        35                  40                  45              


Val Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val 
    50                  55                  60                  


Arg Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu 
65                  70                  75                  80  


Arg Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe 
                85                  90                  95      


Phe Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys 
            100                 105                 110         


Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met 
        115                 120                 125             


His Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp 
    130                 135                 140                 


Val Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr 
145                 150                 155                 160 


Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu 
                165                 170                 175     


Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe 
            180                 185                 190         


Ile Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys 
        195                 200                 205             


Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly 
    210                 215                 220                 


Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro 
225                 230                 235                 240 


Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe 
                245                 250                 255     


Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln 
            260                 265                 270         


Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr 
        275                 280                 285             


Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly 
    290                 295                 300                 


Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu 
305                 310                 315                 320 


Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe 
                325                 330                 335     


Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn 
            340                 345                 350         


Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp 
        355                 360                 365             


Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met 
    370                 375                 380                 


Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu 
385                 390                 395                 400 


Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val 
                405                 410                 415     


Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln 
            420                 425                 430 


<210>  13
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Leu His Ser Met Arg Lys Ala Arg Glu Arg Trp Ser Phe Ile 
1               5                   10                  15      


Arg Ala Leu His Lys Gly Ser Ala Ala Ala Pro Ala Leu Gln Lys Asp 
            20                  25                  30          


Ser Lys Lys Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Leu His 
        35                  40                  45              


Leu Gly Asn Tyr Leu Gly Ala Ile Glu Ser Trp Val Arg Leu Gln Asp 
    50                  55                  60                  


Glu Tyr Asp Ser Val Leu Tyr Ser Ile Val Asp Leu His Ser Ile Thr 
65                  70                  75                  80  


Val Pro Gln Asp Pro Ala Val Leu Arg Gln Ser Ile Leu Asp Met Thr 
                85                  90                  95      


Ala Val Leu Leu Ala Cys Gly Ile Asn Pro Glu Lys Ser Ile Leu Phe 
            100                 105                 110         


Gln Gln Ser Gln Val Ser Glu His Thr Gln Leu Ser Trp Ile Leu Ser 
        115                 120                 125             


Cys Met Val Arg Leu Pro Arg Leu Gln His Leu His Gln Trp Lys Ala 
    130                 135                 140                 


Lys Thr Thr Lys Gln Lys His Asp Gly Thr Val Gly Leu Leu Thr Tyr 
145                 150                 155                 160 


Pro Val Leu Gln Ala Ala Asp Ile Leu Leu Tyr Lys Ser Thr His Val 
                165                 170                 175     


Pro Val Gly Glu Asp Gln Val Gln His Met Glu Leu Val Gln Asp Leu 
            180                 185                 190         


Ala Gln Gly Phe Asn Lys Lys Tyr Gly Glu Phe Phe Pro Val Pro Glu 
        195                 200                 205             


Ser Ile Leu Thr Ser Met Lys Lys Val Lys Ser Leu Arg Asp Pro Ser 
    210                 215                 220                 


Ala Lys Met Ser Lys Ser Asp Pro Asp Lys Leu Ala Thr Val Arg Ile 
225                 230                 235                 240 


Thr Asp Ser Pro Glu Glu Ile Val Gln Lys Phe Arg Lys Ala Val Thr 
                245                 250                 255     


Asp Phe Thr Ser Glu Val Thr Tyr Asp Pro Ala Gly Arg Ala Gly Val 
            260                 265                 270         


Ser Asn Ile Val Ala Val His Ala Ala Val Thr Gly Leu Ser Val Glu 
        275                 280                 285             


Glu Val Val Arg Arg Ser Ala Gly Met Asn Thr Ala Arg Tyr Lys Leu 
    290                 295                 300                 


Ala Val Ala Asp Ala Val Ile Glu Lys Phe Ala Pro Ile Lys Arg Glu 
305                 310                 315                 320 


Ile Glu Lys Leu Lys Leu Asp Lys Asp His Leu Glu Lys Val Leu Gln 
                325                 330                 335     


Ile Gly Ser Ala Lys Ala Lys Glu Leu Ala Tyr Thr Val Cys Gln Glu 
            340                 345                 350         


Val Lys Lys Leu Val Gly Phe Leu 
        355                 360 


<210>  14
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Leu His Ser Met Arg Lys Ala Arg Glu Arg Trp Ser Phe Ile 
1               5                   10                  15      


Arg Ala Leu His Lys Gly Ser Ala Ala Ala Pro Ala Leu Gln Lys Asp 
            20                  25                  30          


Ser Lys Lys Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Leu His 
        35                  40                  45              


Leu Gly Asn Tyr Leu Gly Ala Ile Glu Ser Trp Val Arg Leu Gln Asp 
    50                  55                  60                  


Glu Tyr Asp Ser Val Leu Tyr Ser Ile Val Asp Leu His Ser Ile Thr 
65                  70                  75                  80  


Val Pro Gln Asp Pro Ala Val Leu Arg Gln Ser Ile Leu Asp Met Thr 
                85                  90                  95      


Ala Val Leu Leu Ala Cys Gly Ile Asn Pro Glu Lys Ser Ile Leu Phe 
            100                 105                 110         


Gln Gln Ser Gln Val Ser Glu His Thr Gln Leu Ser Trp Ile Leu Ser 
        115                 120                 125             


Cys Met Val Arg Leu Pro Arg Leu Gln His Leu His Gln Trp Lys Ala 
    130                 135                 140                 


Lys Thr Thr Lys Gln Lys His Asp Gly Thr Val Gly Leu Leu Thr Tyr 
145                 150                 155                 160 


Pro Val Leu Gln Ala Ala Asp Ile Leu Leu Tyr Lys Ser Thr His Val 
                165                 170                 175     


Pro Val Gly Glu Asp Gln Val Gln His Met Glu Leu Val Gln Asp Leu 
            180                 185                 190         


Ala Gln Gly Phe Asn Lys Lys Tyr Gly Glu Phe Phe Pro Val Pro Glu 
        195                 200                 205             


Ser Ile Leu Ser Met Cys Val Leu Val Phe Leu Thr 
    210                 215                 220 


<210>  15
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Met Val Ala Trp Thr Thr Lys Asp Ser Lys Lys Arg Val Phe Ser 
1               5                   10                  15      


Gly Ile Gln Pro Thr Gly Ile Leu His Leu Gly Asn Tyr Leu Gly Ala 
            20                  25                  30          


Ile Glu Ser Trp Val Arg Leu Gln Asp Glu Tyr Asp Ser Val Leu Tyr 
        35                  40                  45              


Ser Ile Val Asp Leu His Ser Ile Thr Val Pro Gln Asp Pro Ala Val 
    50                  55                  60                  


Leu Arg Gln Ser Ile Leu Asp Met Thr Ala Val Leu Leu Ala Cys Gly 
65                  70                  75                  80  


Ile Asn Pro Glu Lys Ser Ile Leu Phe Gln Gln Ser Gln Val Ser Glu 
                85                  90                  95      


His Thr Gln Leu Ser Trp Ile Leu Ser Cys Met Val Arg Leu Pro Arg 
            100                 105                 110         


Leu Gln His Leu His Gln Trp Lys Ala Lys Thr Thr Lys Gln Lys His 
        115                 120                 125             


Asp Gly Thr Val Gly Leu Leu Thr Tyr Pro Val Leu Gln Ala Ala Asp 
    130                 135                 140                 


Ile Leu Leu Tyr Lys Ser Thr His Val Pro Val Gly Glu Asp Gln Val 
145                 150                 155                 160 


Gln His Met Glu Leu Val Gln Asp Leu Ala Gln Gly Phe Asn Lys Lys 
                165                 170                 175     


Tyr Gly Glu Phe Phe Pro Val Pro Glu Ser Ile Leu Thr Ser Met Lys 
            180                 185                 190         


Lys Val Lys Ser Leu Arg Asp Pro Ser Ala Lys Met Ser Lys Ser Asp 
        195                 200                 205             


Pro Asp Lys Leu Ala Thr Val Arg Ile Thr Asp Ser Pro Glu Glu Ile 
    210                 215                 220                 


Val Gln Lys Phe Arg Lys Ala Val Thr Asp Phe Thr Ser Glu Val Thr 
225                 230                 235                 240 


Tyr Asp Pro Ala Gly Arg Ala Gly Val Ser Asn Ile Val Ala Val His 
                245                 250                 255     


Ala Ala Val Thr Gly Leu Ser Val Glu Glu Val Val Arg Arg Ser Ala 
            260                 265                 270         


Gly Met Asn Thr Ala Arg Tyr Lys Leu Ala Val Ala Asp Ala Val Ile 
        275                 280                 285             


Glu Lys Phe Ala Pro Ile Lys Arg Glu Ile Glu Lys Leu Lys Leu Asp 
    290                 295                 300                 


Lys Asp His Leu Glu Lys Val Leu Gln Ile Gly Ser Ala Lys Ala Lys 
305                 310                 315                 320 


Glu Leu Ala Tyr Thr Val Cys Gln Glu Val Lys Lys Leu Val Gly Phe 
                325                 330                 335     


Leu 
    


<210>  16

<400>  16
000

<210>  17
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Leu His Ser Met Arg Lys Ala Arg Glu Arg Trp Ser Phe Ile 
1               5                   10                  15      


Arg Ala Leu His Lys Gly Ser Ala Ala Ala Pro Ala Leu Gln Val Ser 
            20                  25                  30          


Glu His Thr Gln Leu Ser Trp Ile Leu Ser Cys Met Val Arg Leu Pro 
        35                  40                  45              


Arg Leu Gln His Leu His Gln Trp Lys Ala Lys Thr Thr Lys Gln Lys 
    50                  55                  60                  


His Asp Gly Thr Val Gly Leu Leu Thr Tyr Pro Val Leu Gln Ala Ala 
65                  70                  75                  80  


Asp Ile Leu Leu Tyr Lys Ser Thr His Val Pro Val Gly Glu Asp Gln 
                85                  90                  95      


Val Gln His Met Glu Leu Val Gln Asp Leu Ala Gln Gly Phe Asn Lys 
            100                 105                 110         


Lys Tyr Gly Glu Phe Phe Pro Val Pro Glu Ser Ile Leu Thr Ser Met 
        115                 120                 125             


Lys Lys Val Lys Ser Leu Arg Asp Pro Ser Ala Lys Met Ser Lys Ser 
    130                 135                 140                 


Asp Pro Asp Lys Leu Ala Thr Val Arg Ile Thr Asp Ser Pro Glu Glu 
145                 150                 155                 160 


Ile Val Gln Lys Phe Arg Lys Ala Val Thr Asp Phe Thr Ser Glu Val 
                165                 170                 175     


Thr Tyr Asp Pro Ala Gly Arg Ala Gly Val Ser Asn Ile Val Ala Val 
            180                 185                 190         


His Ala Ala Val Thr Gly Leu Ser Val Glu Glu Val Val Arg Arg Ser 
        195                 200                 205             


Ala Gly Met Asn Thr Ala Arg Tyr Lys Leu Ala Val Ala Asp Ala Val 
    210                 215                 220                 


Ile Glu Lys Phe Ala Pro Ile Lys Arg Glu Ile Glu Lys Leu Lys Leu 
225                 230                 235                 240 


Asp Lys Asp His Leu Glu Lys Val Leu Gln Ile Gly Ser Ala Lys Ala 
                245                 250                 255     


Lys Glu Leu Ala Tyr Thr Val Cys Gln Glu Val Lys Lys Leu Val Gly 
            260                 265                 270         


Phe Leu 
        


<210>  18
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Ala Val Leu Leu Ala Cys Gly Ile Asn Pro Glu Lys Ser Ile 
1               5                   10                  15      


Leu Phe Gln Gln Ser Gln Val Ser Glu His Thr Gln Leu Ser Trp Ile 
            20                  25                  30          


Leu Ser Cys Met Val Arg Leu Pro Arg Leu Gln His Leu His Gln Trp 
        35                  40                  45              


Lys Ala Lys Thr Thr Lys Gln Lys His Asp Gly Thr Val Gly Leu Leu 
    50                  55                  60                  


Thr Tyr Pro Val Leu Gln Ala Ala Asp Ile Leu Leu Tyr Lys Ser Thr 
65                  70                  75                  80  


His Val Pro Val Gly Glu Asp Gln Val Gln His Met Glu Leu Val Gln 
                85                  90                  95      


Asp Leu Ala Gln Gly Phe Asn Lys Lys Tyr Gly Glu Phe Phe Pro Val 
            100                 105                 110         


Pro Glu Ser Ile Leu Thr Ser Met Lys Lys Val Lys Ser Leu Arg Asp 
        115                 120                 125             


Pro Ser Ala Lys Met Ser Lys Ser Asp Pro Asp Lys Leu Ala Thr Val 
    130                 135                 140                 


Arg Ile Thr Asp Ser Pro Glu Glu Ile Val Gln Lys Phe Arg Lys Ala 
145                 150                 155                 160 


Val Thr Asp Phe Thr Ser Glu Val Thr Tyr Asp Pro Ala Gly Arg Ala 
                165                 170                 175     


Gly Val Ser Asn Ile Val Ala Val His Ala Ala Val Thr Gly Leu Ser 
            180                 185                 190         


Val Glu Glu Val Val Arg Arg Ser Ala Gly Met Asn Thr Ala Arg Tyr 
        195                 200                 205             


Lys Leu Ala Val Ala Asp Ala Val Ile Glu Lys Phe Ala Pro Ile Lys 
    210                 215                 220                 


Arg Glu Ile Glu Lys Leu Lys Leu Asp Lys Asp His Leu Glu Lys Val 
225                 230                 235                 240 


Leu Gln Ile Gly Ser Ala Lys Ala Lys Glu Leu Ala Tyr Thr Val Cys 
                245                 250                 255     


Gln Glu Val Lys Lys Leu Val Gly Phe Leu 
            260                 265     


<210>  19
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Leu His Ser Met Arg Lys Ala Arg Glu Arg Trp Ser Phe Ile 
1               5                   10                  15      


Arg Ala Leu His Lys Gly Ser Ala Ala Ala Pro Ala Leu Gln Lys Asp 
            20                  25                  30          


Ser Lys Lys Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Leu His 
        35                  40                  45              


Leu Gly Asn Tyr Leu Gly Ala Ile Glu Ser Trp Val Arg Leu Gln Asp 
    50                  55                  60                  


Glu Tyr Asp Ser Val Leu Tyr Ser Ile Val Asp Leu His Ser Ile Thr 
65                  70                  75                  80  


Val Pro Gln Asp Pro Ala Val Leu Arg Gln Ser Ile Leu Asp Met Thr 
                85                  90                  95      


Ala Val Leu Leu Ala Cys Gly Ile Asn Pro Glu Lys Ser Ile Leu Phe 
            100                 105                 110         


Gln Gln Ser Gln Val Ser Glu His Thr Gln Leu Ser Trp Ile Leu Ser 
        115                 120                 125             


Cys Met Val Arg Leu Pro Arg Leu Gln His Leu His Gln Trp Lys Val 
    130                 135                 140                 


His Thr Arg Ser Cys Trp Gly Gly Ser Ser Pro Ala His Gly Thr Ser 
145                 150                 155                 160 


Ser Gly Ser Ser Thr Arg Phe Gln Gln Glu Val Trp Gly Val Leu Ser 
                165                 170                 175     


Ser Ala Arg Val His Ser His Ile His Glu Glu Gly Lys Ile Pro Thr 
            180                 185                 190         


<210>  20
<211>  481
<212>  PRT
<213>  Mus musculus

<400>  20

Met Ala Asp Met Pro Ser Gly Glu Ser Cys Thr Ser Pro Leu Glu Leu 
1               5                   10                  15      


Phe Asn Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala 
            20                  25                  30          


Gly Asn Ala Pro Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Leu 
        35                  40                  45              


Ser Leu Lys Met Ser Tyr Lys Ala Ala Met Gly Glu Glu Tyr Lys Ala 
    50                  55                  60                  


Gly Cys Pro Pro Gly Asn Pro Thr Ala Gly Arg Asn Cys Asp Ser Asp 
65                  70                  75                  80  


Ala Thr Lys Ala Ser Glu Asp Phe Val Asp Pro Trp Thr Val Arg Thr 
                85                  90                  95      


Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe Gly 
            100                 105                 110         


Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr 
        115                 120                 125             


Gly Gln Arg Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser His 
    130                 135                 140                 


Arg Asp Met Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe 
145                 150                 155                 160 


Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu Gly 
                165                 170                 175     


His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn 
            180                 185                 190         


Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp Lys 
        195                 200                 205             


Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys 
    210                 215                 220                 


Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser 
225                 230                 235                 240 


Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe Tyr Arg Asn Val Val 
                245                 250                 255     


Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly 
            260                 265                 270         


Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Val Gln 
        275                 280                 285             


Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Lys Ile Phe Arg Asp Arg 
    290                 295                 300                 


Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr 
305                 310                 315                 320 


Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro 
                325                 330                 335     


Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr 
            340                 345                 350         


Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr 
        355                 360                 365             


Ala Lys Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly 
    370                 375                 380                 


Arg Asp Thr Val Glu Glu His Arg Gln Phe Gly Gly Asn Cys Glu Val 
385                 390                 395                 400 


Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg 
                405                 410                 415     


Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly 
            420                 425                 430         


Glu Leu Lys Lys Thr Leu Ile Asp Val Leu Gln Pro Leu Ile Ala Glu 
        435                 440                 445             


His Gln Ala Arg Arg Lys Ala Val Thr Glu Glu Thr Val Lys Glu Phe 
    450                 455                 460                 


Met Thr Pro Arg Gln Leu Ser Phe His Phe Gln Cys Phe Cys Phe Asp 
465                 470                 475                 480 


Thr 
    


<210>  21
<211>  475
<212>  PRT
<213>  Mus musculus

<400>  21

Met Ala Asp Met Pro Ser Gly Glu Ser Cys Thr Ser Pro Leu Glu Leu 
1               5                   10                  15      


Phe Asn Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala 
            20                  25                  30          


Gly Asn Ala Pro Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Leu 
        35                  40                  45              


Ser Leu Lys Met Ser Tyr Lys Ala Ala Met Gly Glu Glu Tyr Lys Ala 
    50                  55                  60                  


Gly Cys Pro Pro Gly Asn Pro Thr Ala Gly Arg Asn Cys Asp Ser Asp 
65                  70                  75                  80  


Ala Thr Lys Ala Ser Glu Asp Phe Val Asp Pro Trp Thr Val Arg Thr 
                85                  90                  95      


Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe Gly 
            100                 105                 110         


Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr 
        115                 120                 125             


Gly Gln Arg Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser His 
    130                 135                 140                 


Arg Asp Met Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe 
145                 150                 155                 160 


Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu Gly 
                165                 170                 175     


His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn 
            180                 185                 190         


Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp Lys 
        195                 200                 205             


Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys 
    210                 215                 220                 


Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser 
225                 230                 235                 240 


Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe Tyr Arg Asn Val Val 
                245                 250                 255     


Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly 
            260                 265                 270         


Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Val Gln 
        275                 280                 285             


Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Lys Ile Phe Arg Asp Arg 
    290                 295                 300                 


Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr 
305                 310                 315                 320 


Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro 
                325                 330                 335     


Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr 
            340                 345                 350         


Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr 
        355                 360                 365             


Ala Lys Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly 
    370                 375                 380                 


Arg Asp Thr Val Glu Glu His Arg Gln Phe Gly Gly Asn Cys Glu Val 
385                 390                 395                 400 


Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg 
                405                 410                 415     


Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly 
            420                 425                 430         


Glu Leu Lys Lys Thr Leu Ile Asp Val Leu Gln Pro Leu Ile Ala Glu 
        435                 440                 445             


His Gln Ala Arg Arg Lys Ala Val Thr Glu Glu Thr Val Lys Glu Phe 
    450                 455                 460                 


Met Thr Pro Arg Gln Leu Ser Phe His Phe Gln 
465                 470                 475 


<210>  22
<211>  481
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Met Ala Asp Met Pro Ser Gly Glu Ser Cys Thr Ser Pro Leu Glu Leu 
1               5                   10                  15      


Phe Asn Ser Ile Ala Ala Gln Gly Glu Leu Val Arg Ser Leu Lys Ala 
            20                  25                  30          


Gly Asn Ala Pro Lys Asp Glu Ile Glu Ser Ala Val Lys Met Leu Leu 
        35                  40                  45              


Ser Leu Lys Met Asn Tyr Lys Thr Ala Met Gly Glu Glu Tyr Lys Ala 
    50                  55                  60                  


Gly Cys Pro Pro Gly Asn Ser Thr Ala Gly Ser Asn Gly Asp Pro Asp 
65                  70                  75                  80  


Ala Thr Lys Ala Ser Glu Asp Phe Val Asp Pro Trp Thr Val Arg Thr 
                85                  90                  95      


Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe Gly 
            100                 105                 110         


Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr 
        115                 120                 125             


Gly Gln Arg Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser His 
    130                 135                 140                 


Arg Asp Met Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe 
145                 150                 155                 160 


Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu Gly 
                165                 170                 175     


His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asp 
            180                 185                 190         


Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp Lys 
        195                 200                 205             


Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys 
    210                 215                 220                 


Asp Ile Ile Ala Cys Gly Phe Asp Val Asn Lys Thr Phe Ile Phe Ser 
225                 230                 235                 240 


Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe Tyr Lys Asn Val Val 
                245                 250                 255     


Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly 
            260                 265                 270         


Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Val Gln 
        275                 280                 285             


Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Lys Ile Phe Arg Asp Arg 
    290                 295                 300                 


Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr 
305                 310                 315                 320 


Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro 
                325                 330                 335     


Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr 
            340                 345                 350         


Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr 
        355                 360                 365             


Ala Lys Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly 
    370                 375                 380                 


Arg Asp Thr Val Glu Glu His Arg Gln Phe Gly Gly Asn Cys Glu Val 
385                 390                 395                 400 


Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Ser 
                405                 410                 415     


Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly 
            420                 425                 430         


Glu Leu Lys Lys Thr Leu Ile Asp Val Leu Gln Pro Leu Ile Ala Glu 
        435                 440                 445             


His Gln Ala Arg Arg Lys Ala Val Thr Glu Glu Thr Val Lys Glu Phe 
    450                 455                 460                 


Met Ala Pro Arg Gln Leu Ser Phe His Phe Gln Cys Phe Cys Phe Asp 
465                 470                 475                 480 


Thr 
    


<210>  23
<211>  8
<212>  PRT
<213>  Gallus gallus

<400>  23

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Myc tag

<400>  24

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic FLAG tag

<400>  25

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic V5 tag

<400>  26

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


