                         SEQUENCE LISTING

<110>  Vertex Pharmaceuticals Incorporated
 
<120>  Compositions Comprising an RNA Guide Targeting DMPK and Uses 
       Thereof

<130>  01245-0033-00PCT

<150>  US 63/129,124
<151>  2020-12-22

<150>  US 63/142,637
<151>  2021-01-28

<160>  156   

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
guugcaaaac ccaagaaauc cgucuuucau ugacgg                                 36


<210>  2
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2
aauagcggcc cuaagaaauc cgucuuucau ugacgg                                 36


<210>  3
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
auuggaacug gcgagaaauc cgucuuucau ugacgg                                 36


<210>  4
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
ccagcaacac cuaagaaauc cgucuuucau ugacgg                                 36


<210>  5
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5
cggcgcucga auaggaaauc cgucuuucau ugacgg                                 36


<210>  6
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
guggcaacac cuaagaaauc cgucuuucau ugacgg                                 36


<210>  7
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
guugcaacac cuaagaaauc cgucuuucau ugacgg                                 36


<210>  8
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
guugcaaugc cuaagaaauc cgucuuucau ugacgg                                 36


<210>  9
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
gcaacaccua agaaauccgu cuuucauuga cggg                                   34


<210>  10
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
agaaauccgu cuuucauuga cgg                                               23


<210>  11
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
gggcagatgg agggcctttt attcgcgagg                                        30


<210>  12
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
ggcagatgga gggcctttta ttcgcgaggg                                        30


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
tattcgcgag ggtcgggggt gggggtccta                                        30


<210>  14
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
attcgcgagg gtcgggggtg ggggtcctag                                        30


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
ttcgcgaggg tcgggggtgg gggtcctagg                                        30


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
gcgagggtcg ggggtggggg tcctaggtgg                                        30


<210>  17
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
gggttgttgg gggtcctgta gcctgtcagc                                        30


<210>  18
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
ttgggggtcc tgtagcctgt cagcgagtcg                                        30


<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
ggggtcctgt agcctgtcag cgagtcggag                                        30


<210>  20
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
ggcaaaagca aatttcccga gtaagcaggc                                        30


<210>  21
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
gcaaaagcaa atttcccgag taagcaggca                                        30


<210>  22
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22
cccgagtaag caggcagaga tcgcgccaga                                        30


<210>  23
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23
ccgagtaagc aggcagagat cgcgccagac                                        30


<210>  24
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24
gcactttgcg aaccaacgat aggtgggggt                                        30


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25
cactttgcga accaacgata ggtgggggtg                                        30


<210>  26
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26
gcgaaccaac gataggtggg ggtgcgtgga                                        30


<210>  27
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27
cgaaccaacg ataggtgggg gtgcgtggag                                        30


<210>  28
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28
ctgccttccc aggcctgcag tttgcccatc                                        30


<210>  29
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29
ccaggcctgc agtttgccca tccacgtcag                                        30


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30
gcccatccac gtcagggcct cagcctggcc                                        30


<210>  31
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31
cccatccacg tcagggcctc agcctggccg                                        30


<210>  32
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32
ccggctacaa ggacccttcg agccccgttc                                        30


<210>  33
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33
gagccccgtt cgccggccgc ggacccggcc                                        30


<210>  34
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
gccggccgcg gacccggccc ctccctcccc                                        30


<210>  35
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35
tgaactggca ggcggtgggc gcggcttctg                                        30


<210>  36
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
tgtgccgtgc cccgggcact cagtcttcca                                        30


<210>  37
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37
caacggggcc ccggagtcga agacagttct                                        30


<210>  38
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38
tagggttcag ggagcgcggg cggctcctgg                                        30


<210>  39
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39
agggagcgcg ggcggctcct gggcggcgcc                                        30


<210>  40
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40
gactccgggg ccccgttgga agactgagtg                                        30


<210>  41
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41
gaagactgag tgcccggggc acggcacaga                                        30


<210>  42
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42
acaaccgctc cgagcgtggg tctccgccca                                        30


<210>  43
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43
tagccgggaa tgctgctgct gctgctgctg                                        30


<210>  44
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
ctttctttcg gccaggctga ggccctgacg                                        30


<210>  45
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45
tttctttcgg ccaggctgag gccctgacgt                                        30


<210>  46
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46
ctttcggcca ggctgaggcc ctgacgtgga                                        30


<210>  47
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47
tttcggccag gctgaggccc tgacgtggat                                        30


<210>  48
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48
cggccaggct gaggccctga cgtggatggg                                        30


<210>  49
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49
ggccaggctg aggccctgac gtggatgggc                                        30


<210>  50
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50
catcctccac gcacccccac ctatcgttgg                                        30


<210>  51
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51
gttcgcaaag tgcaaagctt tcttgtgcat                                        30


<210>  52
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52
gcaaagtgca aagctttctt gtgcatgacg                                        30


<210>  53
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53
cttgtgcatg acgccctgct ctggggagcg                                        30


<210>  54
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54
ttgtgcatga cgccctgctc tggggagcgt                                        30


<210>  55
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55
tgcatgacgc cctgctctgg ggagcgtctg                                        30


<210>  56
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56
ctcgggaaat ttgcttttgc caaacccgct                                        30


<210>  57
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57
gcttttgcca aacccgcttt ttcggggatc                                        30


<210>  58
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58
cttttgccaa acccgctttt tcggggatcc                                        30


<210>  59
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59
tgccaaaccc gctttttcgg ggatcccgcg                                        30


<210>  60
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60
gccaaacccg ctttttcggg gatcccgcgc                                        30


<210>  61
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61
ccaaacccgc tttttcgggg atcccgcgcc                                        30


<210>  62
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62
ttcggggatc ccgcgccccc ctcctcactt                                        30


<210>  63
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63
tcggggatcc cgcgcccccc tcctcacttg                                        30


<210>  64
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64
cggggatccc gcgcccccct cctcacttgc                                        30


<210>  65
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65
ggggatcccg cgcccccctc ctcacttgcg                                        30


<210>  66
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66
cgctgctctc ggagccccag ccggctccgc                                        30


<210>  67
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67
ggcggtttgg atatttattg acctcgtcct                                        30


<210>  68
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68
ggatatttat tgacctcgtc ctccgactcg                                        30


<210>  69
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69
gatatttatt gacctcgtcc tccgactcgc                                        30


<210>  70
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70
attgacctcg tcctccgact cgctgacagg                                        30


<210>  71
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71
ttgacctcgt cctccgactc gctgacaggc                                        30


<210>  72
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72
acctcgtcct ccgactcgct gacaggctac                                        30


<210>  73
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  73
tggatgcact gagaccccga cattcctcgg                                        30


<210>  74
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74
ggatgcactg agaccccgac attcctcggt                                        30


<210>  75
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  75
gatgcactga gaccccgaca ttcctcggta                                        30


<210>  76
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76
ctcggtattt attgtctgtc cccacctagg                                        30


<210>  77
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  77
attgtctgtc cccacctagg acccccaccc                                        30


<210>  78
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78
ttgtctgtcc ccacctagga cccccacccc                                        30


<210>  79
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  79
tctgtcccca cctaggaccc ccacccccga                                        30


<210>  80
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80
gggcagaugg agggccuuuu auucgcgagg                                        30


<210>  81
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  81
ggcagaugga gggccuuuua uucgcgaggg                                        30


<210>  82
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82
uauucgcgag ggucgggggu ggggguccua                                        30


<210>  83
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  83
auucgcgagg gucgggggug gggguccuag                                        30


<210>  84
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84
uucgcgaggg ucgggggugg ggguccuagg                                        30


<210>  85
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  85
gcgagggucg gggguggggg uccuaggugg                                        30


<210>  86
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86
ggguuguugg ggguccugua gccugucagc                                        30


<210>  87
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  87
uugggggucc uguagccugu cagcgagucg                                        30


<210>  88
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88
gggguccugu agccugucag cgagucggag                                        30


<210>  89
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  89
ggcaaaagca aauuucccga guaagcaggc                                        30


<210>  90
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  90
gcaaaagcaa auuucccgag uaagcaggca                                        30


<210>  91
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  91
cccgaguaag caggcagaga ucgcgccaga                                        30


<210>  92
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  92
ccgaguaagc aggcagagau cgcgccagac                                        30


<210>  93
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  93
gcacuuugcg aaccaacgau aggugggggu                                        30


<210>  94
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  94
cacuuugcga accaacgaua ggugggggug                                        30


<210>  95
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  95
gcgaaccaac gauagguggg ggugcgugga                                        30


<210>  96
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  96
cgaaccaacg auaggugggg gugcguggag                                        30


<210>  97
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  97
cugccuuccc aggccugcag uuugcccauc                                        30


<210>  98
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  98
ccaggccugc aguuugccca uccacgucag                                        30


<210>  99
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  99
gcccauccac gucagggccu cagccuggcc                                        30


<210>  100
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  100
cccauccacg ucagggccuc agccuggccg                                        30


<210>  101
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  101
ccggcuacaa ggacccuucg agccccguuc                                        30


<210>  102
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  102
gagccccguu cgccggccgc ggacccggcc                                        30


<210>  103
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  103
gccggccgcg gacccggccc cucccucccc                                        30


<210>  104
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  104
ugaacuggca ggcggugggc gcggcuucug                                        30


<210>  105
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  105
ugugccgugc cccgggcacu cagucuucca                                        30


<210>  106
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  106
caacggggcc ccggagucga agacaguucu                                        30


<210>  107
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  107
uaggguucag ggagcgcggg cggcuccugg                                        30


<210>  108
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  108
agggagcgcg ggcggcuccu gggcggcgcc                                        30


<210>  109
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  109
gacuccgggg ccccguugga agacugagug                                        30


<210>  110
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  110
gaagacugag ugcccggggc acggcacaga                                        30


<210>  111
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  111
acaaccgcuc cgagcguggg ucuccgccca                                        30


<210>  112
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  112
uagccgggaa ugcugcugcu gcugcugcug                                        30


<210>  113
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  113
cuuucuuucg gccaggcuga ggcccugacg                                        30


<210>  114
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  114
uuucuuucgg ccaggcugag gcccugacgu                                        30


<210>  115
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  115
cuuucggcca ggcugaggcc cugacgugga                                        30


<210>  116
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  116
uuucggccag gcugaggccc ugacguggau                                        30


<210>  117
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  117
cggccaggcu gaggcccuga cguggauggg                                        30


<210>  118
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  118
ggccaggcug aggcccugac guggaugggc                                        30


<210>  119
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  119
cauccuccac gcacccccac cuaucguugg                                        30


<210>  120
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  120
guucgcaaag ugcaaagcuu ucuugugcau                                        30


<210>  121
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  121
gcaaagugca aagcuuucuu gugcaugacg                                        30


<210>  122
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  122
cuugugcaug acgcccugcu cuggggagcg                                        30


<210>  123
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  123
uugugcauga cgcccugcuc uggggagcgu                                        30


<210>  124
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  124
ugcaugacgc ccugcucugg ggagcgucug                                        30


<210>  125
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  125
cucgggaaau uugcuuuugc caaacccgcu                                        30


<210>  126
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  126
gcuuuugcca aacccgcuuu uucggggauc                                        30


<210>  127
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  127
cuuuugccaa acccgcuuuu ucggggaucc                                        30


<210>  128
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  128
ugccaaaccc gcuuuuucgg ggaucccgcg                                        30


<210>  129
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  129
gccaaacccg cuuuuucggg gaucccgcgc                                        30


<210>  130
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  130
ccaaacccgc uuuuucgggg aucccgcgcc                                        30


<210>  131
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  131
uucggggauc ccgcgccccc cuccucacuu                                        30


<210>  132
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  132
ucggggaucc cgcgcccccc uccucacuug                                        30


<210>  133
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  133
cggggauccc gcgccccccu ccucacuugc                                        30


<210>  134
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  134
ggggaucccg cgccccccuc cucacuugcg                                        30


<210>  135
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  135
cgcugcucuc ggagccccag ccggcuccgc                                        30


<210>  136
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  136
ggcgguuugg auauuuauug accucguccu                                        30


<210>  137
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  137
ggauauuuau ugaccucguc cuccgacucg                                        30


<210>  138
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  138
gauauuuauu gaccucgucc uccgacucgc                                        30


<210>  139
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  139
auugaccucg uccuccgacu cgcugacagg                                        30


<210>  140
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  140
uugaccucgu ccuccgacuc gcugacaggc                                        30


<210>  141
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  141
accucguccu ccgacucgcu gacaggcuac                                        30


<210>  142
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  142
uggaugcacu gagaccccga cauuccucgg                                        30


<210>  143
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  143
ggaugcacug agaccccgac auuccucggu                                        30


<210>  144
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  144
gaugcacuga gaccccgaca uuccucggua                                        30


<210>  145
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  145
cucgguauuu auugucuguc cccaccuagg                                        30


<210>  146
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  146
auugucuguc cccaccuagg acccccaccc                                        30


<210>  147
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  147
uugucugucc ccaccuagga cccccacccc                                        30


<210>  148
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  148
ucugucccca ccuaggaccc ccacccccga                                        30


<210>  149
<211>  3162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  149
atgagcagcg cgatcaaaag ctacaagagc gttctgcgtc cgaacgagcg taagaaccaa       60

ctgctgaaaa gcaccattca gtgcctggaa gacggtagcg cgttcttttt caagatgctg      120

caaggcctgt ttggtggcat caccccggag attgttcgtt tcagcaccga acaggagaaa      180

cagcaacagg atatcgcgct gtggtgcgcg gttaactggt tccgtccggt gagccaagac      240

agcctgaccc acaccattgc gagcgataac ctggtggaga agtttgagga atactatggt      300

ggcaccgcga gcgacgcgat caaacagtac ttcagcgcga gcattggcga aagctactat      360

tggaacgact gccgtcaaca gtactatgat ctgtgccgtg agctgggtgt tgaggtgagc      420

gacctgaccc atgatctgga gatcctgtgc cgtgaaaagt gcctggcggt tgcgaccgag      480

agcaaccaga acaacagcat cattagcgtt ctgtttggca ccggcgaaaa agaggaccgt      540

agcgtgaaac tgcgtatcac caagaaaatt ctggaggcga tcagcaacct gaaagaaatc      600

ccgaagaacg ttgcgccgat tcaagagatc attctgaacg tggcgaaagc gaccaaggaa      660

accttccgtc aggtgtatgc gggtaacctg ggtgcgccga gcaccctgga gaaatttatc      720

gcgaaggacg gccaaaaaga gttcgatctg aagaaactgc agaccgacct gaagaaagtt      780

attcgtggta aaagcaagga gcgtgattgg tgctgccagg aagagctgcg tagctacgtg      840

gagcaaaaca ccatccagta tgacctgtgg gcgtggggcg aaatgttcaa caaagcgcac      900

accgcgctga aaatcaagag cacccgtaac tacaactttg cgaagcaacg tctggaacag      960

ttcaaagaga ttcagagcct gaacaacctg ctggttgtga agaagctgaa cgactttttc     1020

gatagcgaat ttttcagcgg cgaggaaacc tacaccatct gcgttcacca tctgggtggc     1080

aaggacctga gcaaactgta taaggcgtgg gaggatgatc cggcggaccc ggaaaacgcg     1140

attgtggttc tgtgcgacga tctgaaaaac aactttaaga aagagccgat ccgtaacatt     1200

ctgcgttaca tcttcaccat tcgtcaagaa tgcagcgcgc aggacatcct ggcggcggcg     1260

aagtacaacc aacagctgga tcgttataaa agccaaaagg cgaacccgag cgttctgggt     1320

aaccagggct ttacctggac caacgcggtg atcctgccgg agaaggcgca gcgtaacgac     1380

cgtccgaaca gcctggatct gcgtatttgg ctgtacctga aactgcgtca cccggacggt     1440

cgttggaaga aacaccatat cccgttctac gatacccgtt tcttccaaga aatttatgcg     1500

gcgggcaaca gcccggttga cacctgccag tttcgtaccc cgcgtttcgg ttatcacctg     1560

ccgaaactga ccgatcagac cgcgatccgt gttaacaaga aacatgtgaa agcggcgaag     1620

accgaggcgc gtattcgtct ggcgatccaa cagggcaccc tgccggtgag caacctgaag     1680

atcaccgaaa ttagcgcgac catcaacagc aaaggtcaag tgcgtattcc ggttaagttt     1740

gacgtgggtc gtcaaaaagg caccctgcag atcggtgacc gtttctgcgg ctacgatcaa     1800

aaccagaccg cgagccacgc gtatagcctg tgggaagtgg ttaaagaggg tcaataccat     1860

aaagagctgg gctgctttgt tcgtttcatc agcagcggtg acatcgtgag cattaccgag     1920

aaccgtggca accaatttga tcagctgagc tatgaaggtc tggcgtaccc gcaatatgcg     1980

gactggcgta agaaagcgag caagttcgtg agcctgtggc agatcaccaa gaaaaacaag     2040

aaaaaggaaa tcgtgaccgt tgaagcgaaa gagaagtttg acgcgatctg caagtaccag     2100

ccgcgtctgt ataaattcaa caaggagtac gcgtatctgc tgcgtgatat tgttcgtggc     2160

aaaagcctgg tggaactgca acagattcgt caagagatct ttcgtttcat tgaacaggac     2220

tgcggtgtta cccgtctggg cagcctgagc ctgagcaccc tggaaaccgt gaaagcggtt     2280

aagggtatca tttacagcta ttttagcacc gcgctgaacg cgagcaagaa caacccgatc     2340

agcgacgaac agcgtaaaga gtttgatccg gaactgttcg cgctgctgga aaagctggag     2400

ctgattcgta cccgtaaaaa gaaacaaaaa gtggaacgta tcgcgaacag cctgattcag     2460

acctgcctgg agaacaacat caagttcatt cgtggtgaag gcgacctgag caccaccaac     2520

aacgcgacca agaaaaaggc gaacagccgt agcatggatt ggttggcgcg tggtgttttt     2580

aacaaaatcc gtcaactggc gccgatgcac aacattaccc tgttcggttg cggcagcctg     2640

tacaccagcc accaggaccc gctggtgcat cgtaacccgg ataaagcgat gaagtgccgt     2700

tgggcggcga tcccggttaa ggacattggc gattgggtgc tgcgtaagct gagccaaaac     2760

ctgcgtgcga aaaacatcgg caccggcgag tactatcacc aaggtgttaa agagttcctg     2820

agccattatg aactgcagga cctggaggaa gagctgctga agtggcgtag cgatcgtaaa     2880

agcaacattc cgtgctgggt gctgcagaac cgtctggcgg agaagctggg caacaaagaa     2940

gcggtggttt acatcccggt tcgtggtggc cgtatttatt ttgcgaccca caaggtggcg     3000

accggtgcgg tgagcatcgt tttcgaccaa aaacaagtgt gggtttgcaa cgcggatcat     3060

gttgcggcgg cgaacatcgc gctgaccgtg aagggtattg gcgaacaaag cagcgacgaa     3120

gagaacccgg atggtagccg tatcaaactg cagctgacca gc                        3162


<210>  150
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  150

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  151
<211>  866
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  151
gcctccggcc cacaacgcaa accgcggaca ctgtggagtc cagagctttg ggcagatgga       60

gggcctttta ttcgcgaggg tcgggggtgg gggtcctagg tggggacaga caataaatac      120

cgaggaatgt cggggtctca gtgcatccaa aacgtggatt ggggttgttg ggggtcctgt      180

agcctgtcag cgagtcggag gacgaggtca ataaatatcc aaaccgccga agcgggcgga      240

gccggctggg gctccgagag cagcgcaagt gaggaggggg gcgcgggatc cccgaaaaag      300

cgggtttggc aaaagcaaat ttcccgagta agcaggcaga gatcgcgcca gacgctcccc      360

agagcagggc gtcatgcaca agaaagcttt gcactttgcg aaccaacgat aggtgggggt      420

gcgtggagga tggaacacgg acggcccggc ttgctgcctt cccaggcctg cagtttgccc      480

atccacgtca gggcctcagc ctggccgaaa gaaagaaatg gtctgtgatc cccccagcag      540

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcattcc      600

cggctacaag gacccttcga gccccgttcg ccggccgcgg acccggcccc tccctccccg      660

gccgctaggg ggcgggcccg gatcacagga ctggagctgg gcggagaccc acgctcggag      720

cggttgtgaa ctggcaggcg gtgggcgcgg cttctgtgcc gtgccccggg cactcagtct      780

tccaacgggg ccccggagtc gaagacagtt ctagggttca gggagcgcgg gcggctcctg      840

ggcggcgcca gactgcggtg agttgg                                           866


<210>  152
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  152

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Arg Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  153
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  153

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  154
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  154

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Gly Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  155
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  155

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Arg Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Arg 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Arg  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Gly Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  156
<211>  3258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  156
atgaaaatcg aagaaggtaa aggtcaccat caccatcacc acatgagctc cgccatcaag       60

tcctacaagt ctgtgctgcg gccaaacgag agaaagaatc agctgctgaa gagcaccatc      120

cagtgcctgg aggacggctc cgccttcttt ttcaagatgc tgcagggcct gtttggcggc      180

atcacccccg agatcgtgag attcagcaca gagcaggaga agcagcagca ggatatcgcc      240

ctgtggtgtg ccgtgaattg gttcaggcct gtgagccagg actccctgac ccacacaatc      300

gcctccgata acctggtgga gaagtttgag gagtactatg gcggcacagc cagcgacgcc      360

atcaagcagt acttcagcgc ctccatcggc gagtcctact attggaatga ctgccgccag      420

cagtactatg atctgtgtcg ggagctgggc gtggaggtgt ctgacctgac ccacgatctg      480

gagatcctgt gccgggagaa gtgtctggcc gtggccacag agagcaacca gaacaattct      540

atcatcagcg tgctgtttgg caccggcgag aaggaggata ggtctgtgaa gctgcgcatc      600

acaaagaaga tcctggaggc catcagcaac ctgaaggaga tcccaaagaa tgtggccccc      660

atccaggaga tcatcctgaa tgtggccaag gccaccaagg agacattcag acaggtgtac      720

gcaggaaacc tgggagcacc atccaccctg gagaagttta tcgccaagga cggccagaag      780

gagttcgatc tgaagaagct gcagacagac ctgaagaaag tgatccgggg caagtctaag      840

gagagagatt ggtgctgtca ggaggagctg aggagctacg tggagcagaa taccatccag      900

tatgacctgt gggcctgggg cgagatgttc aacaaggccc acaccgccct gaagatcaag      960

tccacaagaa actacaattt tgccaagcag aggctggagc agttcaagga gatccagtct     1020

ctgaacaatc tgctggtggt gaagaagctg aacgactttt tcgatagcga gtttttctcc     1080

ggcgaggaga cctacacaat ctgcgtgcac cacctgggcg gcaaggacct gtccaagctg     1140

tataaggcct gggaggacga tcccgccgat cctgagaatg ccatcgtggt gctgtgcgac     1200

gatctgaaga acaattttaa gaaggagcct atcaggaaca tcctgcgcta catcttcacc     1260

atccgccagg agtgtagcgc acaggacatc ctggcagcag caaagtacaa tcagcagctg     1320

gatcggtata agagccagaa ggccaaccca tccgtgctgg gcaatcaggg ctttacctgg     1380

acaaacgccg tgatcctgcc agagaaggcc cagcggaacg acagacccaa ttctctggat     1440

ctgcgcatct ggctgtacct gaagctgcgg caccctgacg gcagatggaa gaagcaccac     1500

atcccattct acgatacccg gtttttccag gagatctatg ccgccggcaa tagccctgtg     1560

gacacctgtc agtttaggac accccgcttc ggctatcacc tgcctaagct gaccgatcag     1620

acagccatcc gcgtgaacaa gaagcacgtg aaggcagcaa agaccgaggc acggatcaga     1680

ctggccatcc agcagggcac actgccagtg tccaatctga agatcaccga gatctccgcc     1740

acaatcaact ctaagggcca ggtgcgcatc cccgtgaagt ttgacgtggg aaggcagaag     1800

ggaaccctgc agatcggcga ccggttctgc ggctacgatc agaaccagac agcctctcac     1860

gcctatagcc tgtgggaggt ggtgaaggag ggccagtacc acaaggagct gggctgtttt     1920

gtgcgcttca tctctagcgg cgacatcgtg tccatcaccg agaaccgggg caatcagttt     1980

gatcagctgt cttatgaggg cctggcctac ccccagtatg ccgactggag aaagaaggcc     2040

tccaagttcg tgtctctgtg gcagatcacc aagaagaaca agaagaagga gatcgtgaca     2100

gtggaggcca aggagaagtt tgacgccatc tgcaagtacc agcctaggct gtataagttc     2160

aacaaggagt acgcctatct gctgcgggat atcgtgagag gcaagagcct ggtggagctg     2220

cagcagatca ggcaggagat ctttcgcttc atcgagcagg actgtggagt gacccgcctg     2280

ggatctctga gcctgtccac cctggagaca gtgaaggccg tgaagggcat catctactcc     2340

tatttttcta cagccctgaa tgcctctaag aacaatccca tcagcgacga gcagcggaag     2400

gagtttgatc ctgagctgtt cgccctgctg gagaagctgg agctgatcag gactcggaag     2460

aagaagcaga aggtggagag aatcgccaat agcctgatcc agacatgcct ggagaacaat     2520

atcaagttca tcaggggcga gggcgacctg tccaccacaa acaatgccac caagaagaag     2580

gccaactcta ggagcatgga ttggctggcc agaggcgtgt ttaataagat ccggcagctg     2640

gccccaatgc acaacatcac cctgttcggc tgcggcagcc tgtacacatc ccaccaggac     2700

cctctggtgc acagaaaccc agataaggcc atgaagtgta gatgggcagc aatcccagtg     2760

aaggacatcg gcgattgggt gctgagaaag ctgtcccaga acctgagggc caagaatatc     2820

ggcaccggcg agtactatca ccagggcgtg aaggagttcc tgtctcacta tgagctgcag     2880

gacctggagg aggagctgct gaagtggcgg tctgatagaa agagcaacat cccttgctgg     2940

gtgctgcaga atagactggc cgagaagctg ggcaacaagg aggccgtggt gtacatccca     3000

gtgaggggcg gccgcatcta ttttgcaacc cacaaggtgg caacaggagc cgtgagcatc     3060

gtgttcgacc agaagcaagt gtgggtgtgt aatgcagatc acgtggcagc agcaaacatc     3120

gcactgaccg tgaagggcat cggcgagcag tcctctgacg aggagaaccc cgatggctcc     3180

aggatcaagc tgcagctgac atctaaaagg ccggcggcca cgaaaaaggc cggccaggca     3240

aaaaagaaaa agtaataa                                                   3258


