                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       Mastaitis, Jason
       Murphy, Andrew J.
       McWhirter, John
       Voronina, Vera
       Gromada, Jesper
 
<120>  NUCLEIC ACIDS ENCODING ANCHOR MODIFIED ANTIBODIES AND USES 
       THEREOF

<130>  009108.507WO1/10507WO01

<150>  63/129,893
<151>  2020-12-23

<150>  63/219,402
<151>  2021-07-08

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  855
<212>  DNA
<213>  Homo sapiens

<400>  1
gagacaggga cagacgtagg ccaagagagg ggaaccagag aggaaccaga ggggagagac       60

agagcagcaa gcagtggatt gctccttgac gacgccagca tgagctcctt ctccaccacc      120

accgtgagct tcctcctttt actggcattc cagctcctag gtcagaccag agctaatccc      180

atgtacaatg ccgtgtccaa cgcagacctg atggatttca agaatttgct ggaccatttg      240

gaagaaaaga tgcctttaga agatgaggtc gtgcccccac aagtgctcag tgagccgaat      300

gaagaagcgg gggctgctct cagccccctc cctgaggtgc ctccctggac cggggaagtc      360

agcccagccc agagagatgg aggtgccctc gggcggggcc cctgggactc ctctgatcga      420

tctgccctcc taaaaagcaa gctgagggcg ctgctcactg cccctcggag cctgcggaga      480

tccagctgct tcgggggcag gatggacagg attggagccc agagcggact gggctgtaac      540

agcttccggt actgaagata acagccaggg aggacaagca gggctgggcc tagggacaga      600

ctgcaagagg ctcctgtccc ctggggtctc tgctgcattt gtgtcatctt gttgccatgg      660

agttgtgatc atcccatcta agctgcagct tcctgtcaac acttctcaca tcttatgcta      720

actgtagata aagtggtttg atggtgactt cctcgcctct cccaccccat gcattaaatt      780

ttaaggtaga acctcacctg ttactgaaag tggtttgaaa gtgaataaac ttcagcacca      840

tggacagaag acaaa                                                       855


<210>  2
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          


Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              


Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  


Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  


Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      


Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys 
            100                 105                 110         


Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser 
        115                 120                 125             


Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu 
    130                 135                 140                 


Gly Cys Asn Ser Phe Arg Tyr 
145                 150     


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Ser Phe Arg Tyr 
1               5   


<210>  4
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G4S DNA sequence


<220>
<221>  CDS
<222>  (1)..(15)

<400>  4
ggt ggc ggc ggt agc                                                     15
Gly Gly Gly Gly Ser                                                       
1               5                                                         


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Gly Gly Gly Gly Ser 
1               5   


<210>  6
<211>  107
<212>  DNA
<213>  Homo sapiens

<400>  6
gcagctacag gtaaggggct tcctagtcct aaggctgagg aagggatcct ggtttagtta       60

aagaggattt tattcacccc tgtgtcctgt ccacaggtgt ccagtcc                    107


<210>  7
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  8
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ANP-VH1-69 without leader


<220>
<221>  CDS
<222>  (1)..(327)

<400>  8
aac agc ttc cgg tac ggt ggc ggc ggt agc cag gtc cag ctg gtg cag         48
Asn Ser Phe Arg Tyr Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln           
1               5                   10                  15                

tct ggg gct gag gtg aag aag cct ggg tcc tcg gtg aag gtc tcc tgc         96
Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys           
            20                  25                  30                    

aag gct tct gga ggc acc ttc agc agc tat gct atc agc tgg gtg cga        144
Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg           
        35                  40                  45                        

cag gcc cct gga caa ggg ctt gag tgg atg gga ggg atc atc cct atc        192
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile           
    50                  55                  60                            

ttt ggt aca gca aac tac gca cag aag ttc cag ggc aga gtc acg att        240
Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile           
65                  70                  75                  80            

acc acg gac gaa tcc acg agc aca gcc tac atg gag ctg agc agc ctg        288
Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu           
                85                  90                  95                

aga tct gag gac acg gcc gtg tat tac tgt gcg aga gac                    327
Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp                       
            100                 105                                       


<210>  9
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Asn Ser Phe Arg Tyr Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
1               5                   10                  15      


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
            20                  25                  30          


Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile 
    50                  55                  60                  


Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile 
65                  70                  75                  80  


Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                85                  90                  95      


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
            100                 105                 


<210>  10
<211>  583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ANP-VH1-69 Cas9/BHR donor

<400>  10
ctcgagcagc tacaggtaag gggcttccta gtcctaaggc tgaggaaggg atcctggttt       60

agttaaagag gattttattc acccctgtgt cctgtccaca ggtgtccagt ccaacagctt      120

ccggtacggt ggcggcggta gccaggtcca gctggtgcag tctggggctg aggtgaagaa      180

gcctgggtcc tcggtgaagg tctcctgcaa ggcttctgga ggcaccttca gcagctatgc      240

tatcagctgg gtgcgacagg cccctggaca agggcttgag tggatgggag ggatcatccc      300

tatctttggt acagcaaact acgcacagaa gttccagggc agagtcacga ttaccacgga      360

cgaatccacg agcacagcct acatggagct gagcagcctg agatctgagg acacggccgt      420

gtattactgt gcgagagaca cagtgtgaaa acccacatcc tgagagtgac aaaaaccctg      480

agggcgccgg cggaattcaa gcttcctagg cgccggcgag aaggcagctg tgccgggctg      540

aggagatgac aggggttatt aggtttaagg ctgtttactc gag                        583


<210>  11
<211>  19726
<212>  DNA
<213>  Mus musculus

<400>  11
aagcttatct ctctgttgct cagactcatc taggaatttc agaaatttct gttctagcat       60

ctcttccagc ttttgtctcc aaccctcatt ctcttctttc tttttttttt taaattatat      120

gttctctgtc tttttaaaaa actttttaaa attaggtatt tatgtcattt acatttccaa      180

tgctatccca aaagtcccac ccacgctccc caacccacta tcccacccac ccactcccac      240

ttcttggccc tggcattcac agtgtactga gacatataaa gtttgcacaa ccaatgggcc      300

tctctttcca ctgatggccg actaggccat cttctgatac atatgcagct agagacacga      360

gattctgggg gtactggtta gttcatattg ttgttccacc tatagggttg cagatccttt      420

tagctccttg ggtactttct ctagctcctc cattgggggc cctgtgatcc atccaatagc      480

tgactgtgag catccacttc tgtgtttgct aggccccaga tagtctcaca agagacagct      540

atatctgggt cctttcagca aaatcttgct agtgtatgca acggtgtcag agtttggaag      600

ctgattatgg gatggatccc cggatatggc attctctagt tggttcatcc ttttgtctca      660

gctccaaact ttgtctctgt aactccttcc atgggtgttt tgttcccagt tctaaggagg      720

ggcaaagtat ccacactttg gtcttcattc ttcttgagtt tcatgtgttt tgcaaattgt      780

atcttatatc ttgggtattc taagtttctg ggctaatatc cacttatcag tgagtacaca      840

ttgtgtgagt tcttttgtga ttgggttacc tcactcagta tgatgccctc caggtccatc      900

catttgccta ggaatttcat aaattcattc tttttaatag ctcagtagta ctccattgtg      960

tagatgtacc acattttctg tattcattcc tctgttgagg ggcatctggg ttctttccag     1020

cttctggcta ttataaataa ggctgctatg aacatagtgg agcatgtgac cttcttaccg     1080

gttgggacat cttctggata tatgcccagg agaggtattg ctggatcttc cggtagtact     1140

atgtccaatt ttctgaggaa ctgacaaact gatttccaga gtggttagta ccagcttgca     1200

atcccaccaa caatgagagg agtgttcgtc tttctccaca tcctcaccag catgctgctg     1260

tcacctgaat ttttgatgct tagccattct gactggtgtg aggtggaatc tcagggttgt     1320

tttgatttgt atttccctga tgattaagga tgctgaacat tttctcaggt gcttctcagc     1380

cattcagtat tctttaggtg agaattcttt gtttagctct aagccccatt tttttaatgg     1440

ggttatttga ttttctggag tccaccttct tgagtttttt tttccatttt ttattacata     1500

atttcctcaa ttacatttcc aatgctatcc caaaagtccc ccataccctc ccccccccaa     1560

ttccctaccc accccttccc atttttttgg ccctggcgtt cccctgtact ggggcatata     1620

aagtttgtgt gtccaatggg cttctctttc cagtgatggc tgactaggcc atcttttgat     1680

acatatgcag ctagagtcaa gagctcccgg gtactggtta gttcataatg ttgttccacc     1740

tatagggttg cagatccctt tagcttcttg ggtactttct ctagctcctc cattgggagc     1800

cctgtgatcc atccaatagc tgactgtgag catccacttc tgtgtttgct aggccccggc     1860

atagtctcac aagagacagc tacatctggg tccttttgat aaaatcttgc tagtgtatgc     1920

aagggtgtca gcatttggaa gctgattatg gggtggatcc ctggatatgg cagtctctac     1980

atggtccatc cttttgtctc agctccaaac tttgtctctg taacttcttc catgagtgtt     2040

ttgttcccaa ttctaaggag gggcatagtg tccacacttc attcttcatt cttcttgagt     2100

ttcatgtgtt tagcaaattg tatcttatat cttgggtatc ctaggttttg ggctaatatc     2160

cacttatcag tgagtacata ttgtgtgagt tcctttgtaa atgtgttacc tcactcagga     2220

tgacgccctc caggtccatc catttggcta ggaatttcat aaattcattc tttttaatag     2280

ctgagtagta ctccattgtg taaatgtacc acattttctg tactcattcc tctgttgagg     2340

ggcatctggg ttctttatag gttctggcta ttataaataa ggttgctatg aacatagtgg     2400

agcatgtgtc cttcttaccg gttgagacat cttctggata tatgcccagg cgaggtattg     2460

ctggatcctc cggtagtact atgtccaatt ttctgaggaa ctgccagact gatttccaga     2520

gtggttgtac aagcctgcac tctcaccaac aatggaggag tgttcctctt tctccacatc     2580

cacgccagca tctgctgtca cctgaatttt tgatcttagc cattctgact ggtgtgaggt     2640

ggaatctcag ggttgttttg atttgcattt ccctgatgat taaggatgtt gaacattttt     2700

ttcaggtgct tctctgccat tcggtattcc tcaggtgaga attctttgtt cagttctgag     2760

ccccattttt taatggggtt atttgatttt ctgaagtcca ccttcttgag ttctttatat     2820

atgttggata ttagtcccct atctgattta cgataggtaa agatcctttc ccaatctgtt     2880

ggtggtcttt ttctcttatt gacggtgtct tttgccttgc agaaactttg gagtgagttc     2940

tttatatata ttggatatta gtcccctatc tgatttagga taggtaaaga tcctttccca     3000

atctgttggt gacctttttg tcttattgac ggtgtctttt gccttgcaga atctttgcaa     3060

ttttatgagg tcgcatttgt caattctcga tcttacagca caagtcattg ctgttctgtt     3120

caggaatttt tcctctgtgc ccatatcttc gaggctttta cctgctttct cctctatatg     3180

tttgagtgtc tctggtttaa tgtggagttc cttaatccac ttagatttga ccttagtaca     3240

aggagatagg aatggatcaa ttcgcattct tctacatgat aaccgctagt tgtgccagca     3300

ccatttgttg ataatgctgt cttttttcca ctggatggtt tttgctccct tgtctaagat     3360

caagtgacca taggtgtgtg ggttcatttc tgggtcttca attctatttc attggtctac     3420

ttgtctgttg ttataccagt accatgcaga ttttatcaca attgctctgt agtagagttt     3480

taggtcaggc atggtgatta caccagaggt tttttttatc cttgagcaga gtttttgcta     3540

tcctaggttt tgtgttattt cagatgaatt tgcagattgc cctttccagt tcgttgaaga     3600

attgagttgg aattttgatg gggattgcat tgaatctgta gattgctttg gcaatatagc     3660

catttttact atattgatcc tgccaatcca tgagcatggg agatctttcc atcttctcaa     3720

atcttcttta atttctttct tcagagactt gaagttcttg tcatacagat ctttcacttc     3780

cttagttaga gtcacgctaa ggtattttat attatttgtg actattgaga agggtgttgt     3840

ttccctaatt tctttctcag cctgtttatc ctttgtgtac agaaaagcca ttgacttgtg     3900

ttagttaatc tcatatccag ctacttcact gaagcggttt atcaggttta ggagttctct     3960

ggtgtaattt ttagggtcac tcatatatac tatcatatca tctgcaaaaa gtgacatttt     4020

gacttcttcc tttccaattt gtatcccctt gatctccttt tgttgtcgaa ttgctctggc     4080

aaggacatca agtactatat tgaataggta gggagaaaat cggcaccctt gtctagtccc     4140

tgattttagt aggattgctt caagtttctc accatttact ttgatgttgg ctactggttt     4200

gctgttgaat gctttttatc atgtttaggt atgggccttg aattcctgat ctttccaaga     4260

cttttatcat gaaagggtgt tggattttgt caaatgcttt ctccagcctt tcattctgag     4320

gttgtgtctg tctttttccc tgagatgggt ttcctgtaag cagcaaaatg ttgggtcctg     4380

tttgtgtagc ccgtctgtta ttctatgtct ttttattggg gagttgagtc cattgatatt     4440

aagatatatt aaggaaaagt aattgttgct tcctattatt tttgttttta aagttggcat     4500

tctgttcttg tggctgtctt cttttaggtt tgttgaagga ttcctttctt gctttttcta     4560

ggtcgtggtt tccatccttg tattcatttt ttttctgtta ttatcctttg aaggactgga     4620

ttcatggata gataatgtgt gaatttggtt ttgtcttgga atacttttgt ttctccatct     4680

acggtaattg agagtttggc tgggtatagt agcctgggct ggcaattgtg ttgtcttagt     4740

gtctatataa tgtctgtcca ggatcttctg gctttcatag tctgtggtga aaaatctggt     4800

gtaattctga taggcttgcc tttatatgtt acttgaattt ttcacttact gcttttaata     4860

ttctttcttt atttagtgca tttgttgttc tgattattat gtgtcgggag gaatttcttt     4920

tctggtccag tctatttgga gttctgtagg cttcttgtat gttcacgggc atctctttct     4980

ttaggtttgg gaagttttct tctataattt tgttgaagat atttgctggc ccttcaagtt     5040

gaaaatgttc attctcatct actcctatta ttcgtatggt tggtcttctc attgtgtcct     5100

ggatttcctg gatgttttga gttaggatct ttttgcattt tccattttct ttgattgttg     5160

tgcagatgtt ctctatggaa tcttctgcac ctgatattct ctcttccatc tcttgtagtc     5220

tgttgctgat gctcgcatct atggttccag atttctttcc tagggtttct atctccagtg     5280

ttgccccact ttgggttttc tgtatagtgt ctacttccct ttttagatct agtatggttt     5340

tgttcatttc catcacctgt ttgggtgtgt tttcctgttt ttctttaaag acttgcaact     5400

ctttagcaga gttctcctgt atttaagtga gttattaaag tccttcttga tgtccagtac     5460

cataattgtg agatatgcct ttaaatccaa gtctaggttt ttgggtgtgt tggggtgccc     5520

tggactggct gagttgggag tgctgcattc tgatgatggt gagtggtctt ggtttctgct     5580

agtaagattc ttacatctgc ctttcgccat ctggtaatct ctggagtcag ttgttaaagt     5640

tgtctctggt taaagcttgt tcctctcgtg attctgttat tctcttccag cagacctggg     5700

agactagctc tttcctgagt ttcagtggtc agagcactct ctgcaggcag gatttcctct     5760

ttcagggaag gtgcacagat atctggtgtt cagatttgcc tcctggcaga agatgatggc     5820

ctgaaacagg acctgtccca gaagctgtta gcttctgtag tcaacactgt cacctgtgca     5880

gactagtctc ggtggagtcc gggaaccaag atgtctcctg cagatgctct ggcattccct     5940

tctgggccgg gtgatcacct ctcctctggc agggaaggtg ccctggtgtc tggaacccga     6000

aaagggggct gcctcagaag ctctgtggct actgcctgtc ccagaagctg ttagcttctg     6060

tagtccacac tctcacctgt gcagactagt cttggtggag tctgggaacc aagatgtctc     6120

ccgcagatgc tccagccatt ctcctctttc tgttgcttat tttgacctat gaaatcctgg     6180

acatatagtt ctagtgttgc ttgtaatctc ttttctaagc caaggaattt tttttatcta     6240

gggcacaatc ttttgagaag acatattaaa tcaagagaat aaatattgca agaccaataa     6300

atgataaggt atctattttc tttaaatcca tcgctgtcaa accattcaaa atatcctcac     6360

ataaagccaa aaagatattt attgtgtttc ccatcttagt tgagttcaag tcaatatttt     6420

ggtgccattt tgttgcagta aatctctaac acaaatatgc ctgggcaatg aaaacacaac     6480

tcagttaata tgaatacaga ttgttcagat ctaccactac actaccatct tcttcatcta     6540

agagacccct tagaacttgc agtttctcca ggccttgtgc ttctgcgctg cttttcttct     6600

tcttcctctt ctacattgct tctctcataa acctacttct ttttttccct ccttctgttc     6660

catcttccct tttatctgcc caatcattag ctctccttta ttttacaaat taaggtgtga     6720

agccggtttc taggaaatca cctgagtgct gacttgttcc ttgttcagag ccacgcacag     6780

gagaacagaa ttaacatcaa atataattat ccccagggct atccacaaca cgtgcatcct     6840

ataagatcac cacggactaa tgctggtctt caattacaac ataaacaaca aaaaccccac     6900

atatatgtgg aaacaaatcg aactatacaa agaatcaatg aaaccaggag cttgttcttt     6960

gagaaaaatc aacaagatag ataaaccctt agccagacta accagagggc acagagacag     7020

tatccaaatt aataaagtca gaaatgaaag gaagacataa caatgaaata tatcttaaaa     7080

taattaatct gtttgtagac tattagcagt tgaaaatatt aaaatcatgt tctacaaacg     7140

tggaattatt attgataatt ttctcactgt gcttgaaatt agcattttct taatgtttaa     7200

cttcaaagag tttttgctat tttgaaatat taaacatata cttactgata aaataatttc     7260

cctcctaaca acactgataa tcttttttta agtaaactga ttattagaca atgtacacag     7320

atatataatg tgttttaaat actctcccac tgtcaggtgg tatcatatag ggcctttgaa     7380

tatattttta aatgtattat ttgtaatatt ttatggtctc tcctatgctt atttctgaaa     7440

gaatattttg tatgttttga aacaatttag tatttaacat tagatatagg atcctcagtt     7500

atggatagta ttaaatattc attaatgata tttttaaggt ataaaaggat atgaatataa     7560

aagtttaaca aattttatgt attatttgat tctaaaaata ctcaatatta ttaatatgtt     7620

tgatgtttaa aatgcattta aataataaaa acatttaaaa aaataaaatc aagaaatgag     7680

gttctaagca gaggtcaagg aaaatgagga atagaaaaat agtaaaaatc aatatgtcca     7740

tttattcaag gaaagctcct acatagacat tgcaccagat tagcaaatat tatggtcctc     7800

atattagttt aagttaggag actatgctta tgttatctat ttacattcta aggagcctag     7860

acatttgtga atggattaca ttataagagg aggatgtcta cttaagtagg catgaacgcc     7920

tgtgcattgc accctatgag ttccatcagc attccatgat tggagtatga agaacagcat     7980

tatagacatt acccagaacc ttagtggttc tagaatgcca agataaaaca atctaacctt     8040

ctggatagta gggataaatg ttcctatatc atcagaattc actggtgccc tgaggatgtt     8100

accctgctaa ctgacaattc acaggacatc acatggattc tgataagttg cagaaaagag     8160

gagatgcatt caattggtcc tcctccttct aagctgcaat attaggtgca tccaatttgt     8220

gaacttcaat ttagattaca atagacatga ataatctgaa ttcatgtagt acatattttt     8280

gttttaatat gagttaccat tgttcagaaa attaaataca catgatcaca tattcctaca     8340

tagtgctgtt agtttttcac atctctggga caatattcca aatatctcct tcattagtga     8400

aaatatcaac tactgtaaag cttagctaac atgcctttgc aggaataaga acatcctgga     8460

ttgaaagcta cacagggaga tgtaaaactt tctaagcaca cacattctcc atccattagg     8520

atcatggtcc atgagatttt tctctctctc ttcttcccat taaatgcatg tacatgcagg     8580

ttgggaaaca gattgtgttg cagaatacat ttgcttgatt tccacttcct tctcaatgca     8640

aatatttttg aagtgttaat tttgctgtga gtaccacagt ggttcttgct ctttctgttg     8700

actcctgtct gtgaatgttc caggaattca cacatggaca cacgtggggc tgcatctgag     8760

ctccagactc actgttgtcc ttctgtcctc agctgctctg gcccaggcac agcctcgtga     8820

attcaacaaa gaccctgatc tctcttgttt acacctcatt acaaatggga actgttagag     8880

gtggacccaa ctgcatttcc atgaggaaag cacatgagtt tgagagggtc gttgatgata     8940

aggtagaaac aactttaatt cataggctga gatatcagtc atcacctcca gataaacaag     9000

agccatttct tcctgcatct gagccctgta agcacactag ctttaggaat atgttactgc     9060

tgaagtcaga ttgggcaact tcatagtata caatagaaaa tctacctgca gatgagttca     9120

gaaccagcag ggggcacaat ggggccaaga atccctagca gagagatgtg gtgtgtgtgc     9180

aggggactct gcatcctctg tggtttcctt tcttaactta catgtacctg tagtgattga     9240

catgtaacgt ttccacgctc aaacactgtg aagatacttt gctaaacact tcaaagattt     9300

atgttttctt gatgtgtgca tgtgtgtatt cttttttgtt tttagacaca gggtttctct     9360

gtgtagtcct ggctgccctg gaactcactc tgtagaccag gctggcctcg aactcagaaa     9420

tctgcctgct tctgcctccc aagtgctgaa gttaaagaca tgtgccacca ttgcctggcc     9480

atgtgtgtat tcttgatgca ctcttctgtt gacagataca cagtttattt ccataattta     9540

tttattgtga tggtgctgca ataatcactt atgtacaaat gtttctgaag tatatttagt     9600

tttggtcatt tgggtgatta tttttttctt tctagtatat agcattttgg aaaggtagat     9660

attaattgta tgtatgggaa ggaggctgta aattctaata acttagctgc ttttgaaatt     9720

tgtcctcaat tctatcatcc ttgtaaccac cttaaatcca tctattagcc ttgtcacaag     9780

tgagccactg tctcaggctg caaatctttt tatagattag gtcgtgatgt tacatccaca     9840

gcctctgcac aatgctcagg ggtgggatat gggatgaatt ccctcagaca gcattaggac     9900

ttggatctca gcagactgat tcttgaccca aatgtctctt cttctctagc aggagtaagt     9960

ccttatctaa gatgtactct gctcatgaat atgcaaatca attgagtcta tggtggtaaa    10020

tatagggatg tctacacccc tcaaaaactt aagatcactg tcgtcttcac agtcacagga    10080

gtacacagga catcaccatg tgttggagct gtatcatcct cttcctgtta gcaacagctg    10140

cacgtaaggg gcttacagta gcaggcttga ggtctggcca tacactcatg tgacaatgac    10200

atccactctg tccttccctt cacaggtgtg cactcccagg tccagctgca gcagtctggg    10260

gctgagctgg tgaggcctgg ggcctcagtg aagatttcct gcaaggcttt tggctacacc    10320

ttcacaaacc atcatataaa ctgggtgaag cagaggcctg gacagggcct ggactggatt    10380

ggatatatta atccttataa tgattatact agctacagaa ccagaagttc aagggcaagg    10440

ccacattgac tgtagacaaa tcctccagca cagcctatat ggagcttagc agcctgacat    10500

ctgaggactc tgcagtctat tactgtgcaa gacacagtgc tacaaacaca tcctgagtgt    10560

gtcagaaacc ctggaggaga agcaagcaga gctggaatgg agatgacaga aagattatca    10620

tttagacttg ctcagaaaga gaaattttga atgcccattt attgcctctt ccttacagta    10680

ctatagtgcc tgtttttgtt gacattttca aactaatttc caaagtcact accacaattt    10740

acaatcacat aaaaagcaag caaggataac attattttct gtgcttactt gccatttata    10800

ttcttgctta ttctcatctc actgaggtca tattgggaca ttaaatttct ggggttactt    10860

tttattaaaa atttttcatt attcattcac tttacatcct tctagtcttc ctctcacaca    10920

tgccctatcc ctttctcctc tgagaggatg gagccctccc taccctcgta tccccttacc    10980

caggcacatc aagtgtctgc agtactagga atattctctg tcaatgctgc cagacaaggc    11040

agacaagtta ggggatcagg attcacagga aggcaacagc ttgagggaca gcccccactg    11100

aagttattgg tggattcaca tgaagactga gttgcacatc tgctacatat attcaggggt    11160

cctatttaca gctcaagtag actcttgttg gtggtttagt ctcttagaac cccaagtgtc    11220

caggttagtt gactctgtgg gtcttccttt ggagttccta tcccctccag atccctcagt    11280

tcttctccca actcttccat aagacacccg taggtccatc caatgtttgg ttttgggttt    11340

ttctgcatct gcttcagtca gctgctgggt ggagcatctc tgaggataat tatgagaagc    11400

tcttatgtgc aagcataaca ggatatcatt attagtgtca gggactggtg cttggccatg    11460

ggatgggtct caagtttggt cagttatttg gccattccca cagtctctga taatctttgt    11520

ccctgcattt cttgtagaca ggaaaaatat tgggttgaaa gttttgtggg tgggttggcg    11580

tctctattgc tccactgggc ttctttctgg atataggagt ttgcctcttc aggttccata    11640

ttcccaaagt agtgtgtcac actaaggtca ctcccataca gagggacact cattctcttg    11700

ccacgtctct gtccaccttc attggacctg aggttcctga atcatacaga actgcatgtg    11760

tgcaaccaca cagaacaagg ctatctatca gaggcctacc ataccaggac catcaaggtt    11820

caccttactc ccaatactga ctacaaaaag aacatcaagg accaatgcag tctatatgga    11880

taaacacact tgaaagaaca caaacaagat tgagggcaac atgacacctc caaagcatac    11940

ctaaccgagt acagcatgcc ctggatatcc taacacaatc aaaacacaag aaagttacct    12000

taaatccagt cttataaagg tgatgaaggc ctttaaatag gaaatgaatt aatccttagg    12060

ataatacagg acaatacatt cgaacagata gaggtcttta ggaggaaaga aataaatccc    12120

tcaaagacat acatgaaaat acaattaaac aggtgaaagt aataactaca atggtgtaag    12180

acctaaaaat ggaaatagaa gcaataaagt aacacaaact tagaatcttg aaggtggaaa    12240

acctagagaa caggaatact agatgcaagg atgatatctt ctaggtccat ccatttgctt    12300

gcacaattta tcatgtcctt gcttttaata gttgaacagt atttcattgt ttaaatgaac    12360

cacatgttct gtctccattc tctggatgag ggggtgagca agtttttcca cattctggct    12420

attacaaata gagctgctat gaacctagta gaaaacatat cctgtgtatg gtggagagtt    12480

ttggagtata tcaccaagag tgttatagct gggtcttcat gtagaactat tcctaatttt    12540

ctgagaaatc ccaagtcaga tttctagaat ggttgttcaa gtgttcactc caaccatcaa    12600

tggaggactg ttttccttgc cagcatgtgc tgtattttga gtttttgatc ctagccagtt    12660

ttatcctgca tttcacactt agatatggac tatggtacag gacagagaga aaccaacctt    12720

ctactcacca ggatattcta cctgctacca atttatttat ttatttattt atttatttat    12780

ttatttattt atttatttat attagagaac aacaccatgc agtttagaag aagtactaag    12840

acgtcagtga tgttatactg tgcctaacct tgcattgtac aatctcagct ttcaggtaag    12900

acagtgcatg actcttatgc agtgccaact gttttctgat tgtatttatg gtctattgcc    12960

taggaatgac ctcctctcaa ataaacatgg tcaaaagccc atggcctgag atgacagagc    13020

ccctagtaga ccctagttgt atttctgaag tttagatatc ataatgactt ataaatactt    13080

atgtttatac aatagattag agctgctctc agccatgacc aaggagcttc tgtgttcaat    13140

gaataatgat tgatgcagac attcgtgagt ggtcaaagtg gtgagaatga ttagagagtc    13200

ctcagccaca caagcgttaa tgatatgaac tttccaatat attaactgta ttaatgaata    13260

aatgcagaca tcatatgaga tctcattagt agttcttagg tattgcattt ttatatacaa    13320

ttatgcatat cagtacatta tagtgtataa aggaaattgt ctagcataat agagaaaaat    13380

aggacagtca agaaacaaaa gagtagaaat tatgggtgaa atatgcagtg tgaaatattt    13440

acatgaaaat tttaaccata tgtaaaattg ttatttttgt ttttcagaat gagtttgctc    13500

attctttgac atttttattc ctgtgtgaaa tatatcagga tcatatgtat cccattctga    13560

tggtctgact tccactggga atttccaata tatctcttcc aactaactga ccagtttctt    13620

tttttcttat tttctctctt tctcgttttg ttttgctttg ttttgttttt caagacaggg    13680

tttctctgtg tagctctggc tgtcctggaa ctcactttgt agatcaggct ggcttcgagc    13740

tcataaatcc acttgcctct gcctcctgag tgctgggatt aaaggagtgg ctaccacgcc    13800

cggctagttt ttttttttct tataagaaca acatttactg gatggtcact tacatattca    13860

gaggttcagt caattattat caaggcagaa gcatggcagt ggtccagtag tcatggcact    13920

ggggaaggag ctgagagatc tacatcttgc tccaaaggga aagaggaata gtctgacttc    13980

catgtgtttc agaggagggt ttcatttccc acccccacag tgacacactt cctccaacac    14040

ggccacacct cctaatattg ccactcttgg atcaagcata ttcacaccac aaaggaaagt    14100

ttagagataa acattaagaa aattaatgaa gtcattttat cttatatgct caacatgact    14160

agtacttaaa accataattt tacatgtaca atatttcatg gcataacata ttttttatat    14220

ttttattaga tattttcttt atttatattt caaatgtgat accctttccc aattcccctc    14280

caaaaatccc ctatgccttc ccctcatagc cagctcccaa acccacccac tcctgctttc    14340

tggtcctggc attcccctat actggggcat aaaaccttca caggaccaag tgcctcttct    14400

ccattgatgg ccaattaggc catcctctgc tacatatgca gctagagcca tgagttccac    14460

catgtgtttt ctttgattgg tggtttagtt ccagggagct ctgggggtat tggttagttc    14520

atattgttcc tcctatgggg ctgcaaaccc tttcagcccc ttgggtattt tttctagctc    14580

cttcattggg gaccctgtgc tccatccaat ggatgagtga gcctccactt ttgtatttgt    14640

caggaactgg cagagtctct caggagacaa ttatatcagg ctcctgtcag caaaatctcg    14700

ttggcatctg caatagtgtc tgggtttggt ggttgtttat gggatggatt tctgggtggg    14760

gcagtctctg gattgtcatt cctttagtct ctgcttccac ctttgtcttt gtaactccat    14820

ccatgggtat tttgttcccc cttcaaagaa ggatcaaaat atccacactt tagtcttcct    14880

tcttcttgag tctcatgtgt ttttcaaatt gtatcttggg tattctgagc ttctaggcta    14940

atatccactt atcagtgagt gattatcatg tctgttcttt tgtgattgag ttacctcact    15000

tagcatgata tcctccaggt ctatccattt gtctaagaat ttcataaagt cattgtcttt    15060

aatagctgca tcgtactcaa ttgtgtaaat gcaccacatt ttctttatcc attcctctgt    15120

tgagggacac ttggtttttc ccagcttctg gttattataa ataaggctgc tatgaacata    15180

gtggaacatg tgtccttagt acatgttgga acatcttctg ggtatatgcc caggagtggt    15240

attgctggat cttctggtgg tactatgtcc aaatttttgg ggaaccatca aactgatttc    15300

ctgagtggtt gtacaagctt gcaatcccac accagcaata gtggaatgtt catctttgtc    15360

caagtccttg ccagcatctg ctgtcacctg agtttttgat cttagccatt cttactggtg    15420

tgaggtggaa tcttggggtt gttttgattt gcatttccct gatgtttaag ggttttgaac    15480

atttttaggt gcttattaga catttggtat tcctcagttt agaaatcttt gtttagctct    15540

gtaccacatt tttgaatagg gttatttggt tttctggagt ctaacttctt gagttctttg    15600

tacatattgg atattagccc tctatcagat ttagaattag taaggatctt tccccaaact    15660

gttggtggtt cttttgtctt attgacagtg tactttgcct tagagaagct ttgcaatttt    15720

atgaggtccc atttgtcaat tcttgatctt atagtacaag ccattggtct tttgttcagg    15780

aatttttccc atgtgtccat atgttcaagg catttcccca ctttctccac tacaagtttt    15840

agtgtctctg gttttatgtg gaggtccttg atccacttag atttgagctt tgtacaagga    15900

gataagaatg gatagattca cattcttcta catgctctct gccagttgag ctagcaccat    15960

ttgttgaaaa tgctgtcttt tttttccccc actggatggt ttttagctct tttggccaag    16020

atcaagtgac cattggtgtg tgggttcatt tcttggtctt caattctagt tcactgactt    16080

acctgtttgt cactgtacaa ggaccatgca gcttttttca caattgctct gtagtacagc    16140

ttgaggtctg ggatggtgat tctaccagag agattctttt actgttgtga ataatttttg    16200

ctatcatagg atattttttt atttcagatg aatttacaaa ttgctctttc taactctgtg    16260

aacaattgag ttggaatttt gattgtgatt gctttgaata ctcaagatat aatttacaaa    16320

acacatgaaa cttaacaagg actactaaag tgcagatact tcgatccttc ttagaagggg    16380

gaacaaaata cccatagatg gagttacaga gacaaagttc ggagcagaga ctataggaac    16440

gaccatccag aggtccacct ggggatccat catgtaaaca accacccaaa acagacacta    16500

ttgtggatgc caagaagaac ttgctgacag gagtctgata tagctgtctc ttgagaggct    16560

ctgccagggc ctcagaaagt ggaggctcac agccatccat tggatggagc acagggtccc    16620

caatgaagga gctagagaaa gtactcaagg agctgaaggg gtttgcagcc ccataggagg    16680

aacaacaata tgaactaacc agtaccccca gagctccctg ggactaaacc accaatcaaa    16740

gaaaacacat ggagggactt gaagctcttg ctgcatttat agcagaggat ggcctagatg    16800

gtcatcaatg ggaggagagg tcaatggtcc tgggaaggtt ccatgcccca gtatagggga    16860

atgccagggc caggaagcag gagtgggtgg gctggggatc agggaggggg agatgatagg    16920

gcattttcag tggggaaact aggaaagagg ataacattta aaatataaat aaagaaaata    16980

tctaattaaa aaggattacc tatgtgcatg ggagctcatg agcagcaggg gtcactctaa    17040

ggccaataat ccacatagag cgatgagctg tgtgtgaaca ggactctgta tcctctgtgg    17100

tttcctttct taagtgtatt aactgatctg tccagctgtg attgacatgt gatgtctcca    17160

tgctcaagcc cagtaaagat tctctgttaa ataccttaca gacttatgtt tacttgtttt    17220

tatttgcttt tcatattttt ttaaaaagtc atacaatgta ttctaataac tcattctccc    17280

atctccaatt tattctaagt ttttcttaac tcatccaacc acacactttt taattctgat    17340

aaagcacccc cccccccaaa aaaaaaccca accaaccaaa aaaaaaaaaa gccaaggaat    17400

ttaaaagggg attgaaagca aataaaaact aaacaaaaaa gtaaaaacta cacacacaca    17460

cacacacaca cacacacaca cacacacaca cacacactca cacacacaca cacacaccac    17520

acacacacac acccatgcac gaacacacac acacacacac acacacacac acacacacac    17580

acacacacac acacatggaa tccagtaaaa ccacaactct ttacccatga tacacaggaa    17640

aatataagtc aaacaaacag aatggaagaa ggtggtatta taaaaatgtc tgcacaaata    17700

ccattaagtt cattttcttg ttggctacca actgctaagc ctgtctccct tgattaattg    17760

tgcttatcat cccctatgaa ctccattgga ggacactaat ttttccttct gtctccagga    17820

attgaagtgt tgcagaactc tcagtagctt tatttacctg cacaatacag cctctaatcc    17880

aaccagtgaa aattaccaca tgagagactt ccaaatgaaa gaacaggtaa agttgtctac    17940

tggcaagctt agtaatatca tgtaaatgcc ttagaattta atgacatatg tcatcctctg    18000

aggttaataa atccattttg gtgcatatat accctgaact caccactaac ataatacaac    18060

aattaaaaaa ttccaacatg gatgcagagg aatccctgag ggacatttgt tgatttgtga    18120

gcacaatata attatttttt gggggggaaa tgtctgaatg ttaactcttt accagtgata    18180

atctattcta ttaatgtgta cataggtagc actaattaaa atcactgtgt tatcaggtaa    18240

tgaaacagag gaagtaggat gctgggaaac agacttttgg aaggtcccaa gggaaaccac    18300

agggacctag tggtgataga ttatggtgag agtcctgaga gtggtcatag attatagcat    18360

atttcatatg caattgaaaa tttcaaagaa tgaaaatcct tatgaaatat agaaataaca    18420

actttactta tgtacatata cttcatagta caatttttac actgtgcata tttctcctgt    18480

aacatctggt tcctcctatt ttcctttatt ctcctagaca atttcactga tacaatctca    18540

tgtttttgta taaatagttg tatataacta ttaaatacat aagctgttaa tgagtcttca    18600

ttaatgtctg tgattttttt attgtcttaa ttaatactat tatctctaat tgcatccaca    18660

ttttcaaaag caatgtaaat ttcttactca tttctgttca aaaacttctg ttgttgtatc    18720

attaccatgc cttagtgata aaatcctttc ttgacacatc tatagctatt gctataattt    18780

agttattgat gatcctcctg caataatcat tgataggtaa atattttaag cacttttact    18840

tttagtcatt ttagtgagat ttgaagtagt atataacctg ttggaaaggc aaatattaat    18900

tccatatatg tgaaagaaga cgctaaaact aaaaacatta gccactttta gatatcttct    18960

ccttcttctt cttcttcttc ttcttcttct tcttcttctt cttcttcttc ttcttcttct    19020

tcttcttctt cttcttttct tcttcttctt ctccttctcc ttctccttct ccttctcctt    19080

ctcctcttcc tcctccttcc ttccttcctt ccttccttcc ttccttcctt ccttccttcc    19140

ttccttcctt ccttccttcc ttccttcctt ccttccttcc ttccttcctt ccttccttcc    19200

ttcctttctt tctttctttc tttctttctt tctttctttc tttctttctt tctttctttc    19260

tttctttctt tctttctttc tttctttctt ctcctcctcc ttctttttcc ttctccttcc    19320

ccttcacctt ccccttcctt cctctttccc ttccccttct ccttctcctc aatctacaat    19380

ctgttaacat attaacatgt cccagagtag agcaacagac tcaggtcaaa catctactga    19440

gaaatttgcc catgtagtta acatctacag catctgtcta ggggttacaa aaagtctatg    19500

ggatacaatt cctcagaaag gaataggatt tggacctgag catactgctg cctaacacat    19560

gaaatggcag ttcttctcca gctggactag gtccttaact aagaaatgca ctgctcatga    19620

atatgcaaat tacccaagtc tatggcagta aatacagaga tgtccacacc ctgaagacaa    19680

cctatgaaca atgttctctc cacagtccct gaagacactg attcta                   19726


<210>  12
<211>  7928
<212>  DNA
<213>  Mus musculus

<400>  12
ctgagcattg cagactaatc ttggatattt gtccctgagg gagccggctg agagaagttg       60

ggaaataaac tgtctaggga tctcagagcc tttaggacag attatctcca catctttgaa      120

aaactaagaa tctgtgtgat ggtgttggtg gagtccctgg atgatgggat agggactttg      180

gaggctcatt tgagggagat gctaaaacaa tcctatggct ggagggatag ttggggctgt      240

agttggagat tttcagtttt tagaataaaa gtattagctg cggaatatac ttcaggacca      300

cctctgtgac agcatttata cagtatccga tgcataggga caaagagtgg agtggggcac      360

tttctttaga tttgtgagga atgttccaca ctagattgtt taaaacttca tttgttggaa      420

ggagagctgt cttagtgatt gagtcaaggg agaaaggcat ctagcctcgg tctcaaaagg      480

gtagttgctg tctagagagg tctggtggag cctgcaaaag tccagctttc aaaggaacac      540

agaagtatgt gtatggaata ttagaagatg ttgcttttac tcttaagttg gttcctagga      600

aaaatagtta aatactgtga ctttaaaatg tgagagggtt ttcaagtact cattttttta      660

aatgtccaaa attcttgtca atcagtttga ggtcttgttt gtgtagaact gatattactt      720

aaagtttaac cgaggaatgg gagtgaggct ctctcataac ctattcagaa ctgactttta      780

acaataataa attaagtttc aaatattttt aaatgaattg agcaatgttg agttggagtc      840

aagatggccg atcagaacca gaacacctgc agcagctggc aggaagcagg tcatgtggca      900

aggctatttg gggaagggaa aataaaacca ctaggtaaac ttgtagctgt ggtttgaaga      960

agtggttttg aaacactctg tccagcccca ccaaaccgaa agtccaggct gagcaaaaca     1020

ccacctgggt aatttgcatt tctaaaataa gttgaggatt cagccgaaac tggagaggtc     1080

ctcttttaac ttattgagtt caacctttta attttagctt gagtagttct agtttcccca     1140

aacttaagtt tatcgacttc taaaatgtat ttagaattca ttttcaaaat taggttatgt     1200

aagaaattga aggactttag tgtctttaat ttctaatata tttagaaaac ttcttaaaat     1260

tactctatta ttcttccctc tgattattgg tctccattca attcttttcc aatacccgaa     1320

gcatttacag tgactttgtt catgatcttt tttagttgtt tgttttgcct tactattaag     1380

actttgacat tctggtcaaa acggcttcac aaatcttttt caagaccact ttctgagtat     1440

tcattttagg agaaagactt tttttttaaa tgaatgcaat tatctagact tatttcagtt     1500

gaacatgctg gttggtggtt gagaggacac tcagtcagtc agtgacgtga agggcttcta     1560

agccagtcca catgctctgt gtgaactccc tctggccctg cttattgttg aatgggccaa     1620

aggtctgaga ccaggctgct gctgggtagg cctggacttt gggtctccca cccagacctg     1680

ggaatgtatg gttgtggctt ctgccaccca tccacctggc tgctcatgga ccagccagcc     1740

tcggtggctt tgaaggaaca attccacaca aagactctgg acctctccga aaccaggcac     1800

cgcaaatggt aagccagagg cagccacagc tgtggctgct gctcttaaag cttgtaaact     1860

gtttctgctt aagagggact gagtcttcag tcattgcttt agggggagaa agagacattt     1920

gtgtgtcttt tgagtaccgt tgtctgggtc actcacattt aactttcctt gaaaaactag     1980

taaaagaaaa atgttgcctg ttaaccaata atcatagagc tcatggtact ttgaggaaat     2040

cttagaaagc gtgtatacaa ttgtctggaa ttatttcagt taagtgtatt agttgaggta     2100

ctgatgctgt ctctacttca gttatacatg tgggtttgaa ttttgaatct attctggctc     2160

ttcttaagca gaaaatttag ataaaatgga tacctcagtg gtttttaatg gtgggtttaa     2220

tatagaagga atttaaattg gaagctaatt tagaatcagt aaggagggac ccaggctaag     2280

aaggcaatcc tgggattctg gaagaaaaga tgtttttagt ttttatagaa aacactacta     2340

cattcttgat ctacaactca atgtggttta atgaatttga agttgccagt aaatgtactt     2400

cctggttgtt aaagaatggt atcaaaggac agtgcttaga tccgaggtga gtgtgagagg     2460

acaggggctg gggtatggat acgcagaagg aaggccacag ctgtacagaa ttgagaaaga     2520

atagagacct gcagttgagg ccagcaggtc ggctggacta actctccagc cacagtaatg     2580

acccagacag agaaagccag actcataaag cttgctgagc aaaattaagg gaacaaggtt     2640

gagagcccta gtaagcgagg ctctaaaaag cacagctgag ctgagatggg tgggcttctc     2700

tgagtgcttc taaaatgcgc taaactgagg tgattactct gaggtaagca aagctgggct     2760

tgagccaaaa tgaagtagac tgtaatgaac tggaatgagc tgggccgcta agctaaacta     2820

ggctggctta accgagatga gccaaactgg aatgaacttc attaatctag gttgaataga     2880

gctaaactct actgcctaca ctggactgtt ctgagctgag atgagctggg gtgagctcag     2940

ctatgctacg ctgtgttggg gtgagctgat ctgaaatgag atactctgga gtagctgaga     3000

tggggtgaga tggggtgagc tgagctgggc tgagctagac tgagctgagc tagggtgagc     3060

tgagctgggt gagctgagct aagctggggt gagctgagct gagcttggct gagctagggt     3120

gagctgggct gagctggggt gagctgagct gagctggggt aagctgggat gagctggggt     3180

gagctgagct gagctggagt gagctgagct gggctgagct ggggtgagct gggctgagct     3240

gggctgagct gggctgagct ggggtgagct gagctggggt gagctgagct gagctggggt     3300

gagctgagct gagctggggt gagctggggt gagctgagct ggggtgagct gagctgagct     3360

ggggtgagct gagctggggt gagctgagct gagctggggt gagctgagct gagctgagct     3420

gagctgagct ggggtgagct gagctgagct gagctggggt gagctggggt gagctgagct     3480

gagctggagt gagctgagct gggctgagct ggggtgagct gggctgagct ggggtgagct     3540

gagctgagct gagctgagct ggggtgagct gagctgagct ggggtgagct gagctggggt     3600

gagctgggct gagctgagct gagctgagct gagctgagct gagctgagct gagctgagct     3660

gagctgagct gagctgagct gagctgagct gagctggggt gagctgagct gagctgggct     3720

gagctggggt gagctgggct gagctgggct gagctgggct gagctggggt gagctgagct     3780

ggggtgagct gagctgagct gggctgagct gagctgagct ggggtgagct gagctgagct     3840

ggggtgagct gagctgagct gagctggggt gagctgagct gagctgggct gagcagggct     3900

gagctggggt gagctgagct gagctggggt gagctgggct gagctgggct gagctgagct     3960

gagctgggct gagctgggct gagctgggct gagctgggct gagctgggct gagctggggt     4020

gagctgagct ggggtgagct ggggtgagct gagctggggt gagctgagct ggggtgagct     4080

gagctgagct ggggtgagct gagctggggt gagctgagct gagctggggt gagctgagct     4140

gagctggggt gagctgagct agggtgaact gggctgggtg agctggagtg agctgagctg     4200

aggtgaactg gggtgagccg ggatgttttg agttgagctg gggtaagatg agctgaactg     4260

gggtaaactg ggatgagctg tggtgagcgg agctggattg aactgagctg tgtgagctga     4320

gctggggtca gctgagcaag agtgagtaga gctggctggc cagaaccaga atcaattagg     4380

ctaagtgagc cagattgtgc tgggatcagc tgtactcaga tgagctggga tgaggtaggc     4440

tgggatgagc tgggctagct gacatggatt atgtgaggct gagctagcat gggctggcct     4500

agctgatgag ctaagcttga atgagcgggg ctgagctgga ctcagatgtg ctagactgag     4560

ctgtactgga tgatctggtg tagggtgatc tggactcaac tgggctggct gatgggatgc     4620

gccaggttga actaggctca gataagttag gctgagtagg gcctggttga gatggttcgg     4680

gatgagctgg gaaaagatgg actcggacca tgaactgggc tgagctgggt tgggagacca     4740

tgaattgagc tgaactgagt gcagctggga taaactgggt tgagctaaga atagactacc     4800

tgaattgtgc caaactcggc tgggatcaat tggaaattat caggatttag atgagccgga     4860

ctaaactatg ctgagctgga ctggttggat gtgttgaact ggcctgctgc tgggctggca     4920

tagctgagtt gaacttaaat gaggaaggct gagcaaggct agcctgcttg catagagctg     4980

aactttagcc tagcctgagc tggaccagcc tgagctgagt aggtctaaac tgagttaaaa     5040

atcaacaggg ataatttaac agctaattta acaagcctga ggtctgagat tgaatgagca     5100

gagctgggat gaactgaatg agtttcacca ggcctggacc agttaggcta ggacctcgtt     5160

ctatagaggc agactgtgtg ctacagtgga gtttcaagat gattccatga gtcctccccg     5220

cccccaacat aacccacctt cctcctaccc tacacgcctg tctggtgtgt aaatcccagc     5280

tttgtgtgct gatacagaag cctgagcccc tcccccacct ccacctacct attactttgg     5340

gatgagaata gttctcccag ccagtgtctc agagggaagc caagcaggac aggcccaagg     5400

ctacttgaga agccaggatc taggcctctc cctgagaacg ggtgttcatg cccctagagt     5460

tggctgaagg gccagatcca cctactctag aggcatctct ccctgtctgt gaaggcttcc     5520

aaagtcacgt tcctgtggct agaaggcagc tccatagccc tgctgcagtt tcgtcctgta     5580

taccaggttc acctactacc atatctagcc ctgcctgcct taagagtagc aacaaggaaa     5640

tagcagggtg tagagggatc tcctgtctga caggaggcaa gaagacagat tcttacccct     5700

ccatttctct tttatccctc tctggtcctc agagagtcag tccttcccaa atgtcttccc     5760

cctcgtctcc tgcgagagcc ccctgtctga taagaatctg gtggccatgg gctgcctggc     5820

ccgggacttc ctgcccagca ccatttcctt cacctggaac taccagaaca acactgaagt     5880

catccagggt atcagaacct tcccaacact gaggacaggg ggcaagtacc tagccacctc     5940

gcaggtgttg ctgtctccca agagcatcct tgaaggttca gatgaatacc tggtatgcaa     6000

aatccactac ggaggcaaaa acaaagatct gcatgtgccc attccaggta agaaccaaac     6060

cctcccagca ggggtgccca ggcccaggca tggcccagag ggagcagcgg ggtggggctt     6120

aggccaagct gagctcacac cttgaccttt cattccagct gtcgcagaga tgaaccccaa     6180

tgtaaatgtg ttcgtcccac cacgggatgg cttctctggc cctgcaccac gcaagtctaa     6240

actcatctgc gaggccacga acttcactcc aaaaccgatc acagtatcct ggctaaagga     6300

tgggaagctc gtggaatctg gcttcaccac agatccggtg accatcgaga acaaaggatc     6360

cacaccccaa acctacaagg tcataagcac acttaccatc tctgaaatcg actggctgaa     6420

cctgaatgtg tacacctgcc gtgtggatca caggggtctc accttcttga agaacgtgtc     6480

ctccacatgt gctgccagtg agtggcctgg gctaagccca atgcctagcc ctcccagatt     6540

agggaagtcc tcctacaatt atggccaatg ccacccagac atggtcattt gctccttgaa     6600

ctttggctcc ccagagtggc caaggacaag aatgagcaat aggcagtaga ggggtgagaa     6660

tcagctggaa ggaccagcat cttcccttaa gtaggtttgg gggatggaga ctaagctttt     6720

ttccaacttc acaactagat atgtcataac ctgacacagt gttctcttga ctgcaggtcc     6780

ctccacagac atcctaacct tcaccatccc cccctccttt gccgacatct tcctcagcaa     6840

gtccgctaac ctgacctgtc tggtctcaaa cctggcaacc tatgaaaccc tgaatatctc     6900

ctgggcttct caaagtggtg aaccactgga aaccaaaatt aaaatcatgg aaagccctcc     6960

caatggcacc ttcagtgcta agggtgtggc tagtgtttgt gtggaagact ggaataacag     7020

gaaggaattt gtgcgtactg tgactcacag ggatctgcct tcaccacaga agaaattcat     7080

ctcaaaaccc aatggtaggt atcccccctt cccttcccct ccaattgcag gacccttcct     7140

gtacctcata gggagggcag gtcctcttcc accctatcct cactactgtc ttcatttaca     7200

gaggtgcaca aacatccacc tgctgtgtac ctgctgccac cagctcgtga gcaactgaac     7260

ctgagggagt cagccacagt cacctgcctg gtgaagggct tctctcctgc agacatcagt     7320

gtgcagtggc ttcagagagg gcaactcttg ccccaagaga agtatgtgac cagtgccccg     7380

atgccagagc ctggggcccc aggcttctac tttacccaca gcatcctgac tgtgacagag     7440

gaggaatgga actccggaga gacctatacc tgtgttgtag gccacgaggc cctgccacac     7500

ctggtgaccg agaggaccgt ggacaagtcc actggtaaac ccacactgta caatgtctcc     7560

ctgatcatgt ctgacacagg cggcacctgc tattgaccat gctagcgctc aaccaggcag     7620

gccctgggtg tccagttgct ctgtgtatgc aaactaacca tgtcagagtg agatgttgca     7680

ttttataaaa attagaaata aaaaaaatcc attcaaacgt cactggtttt gattatacaa     7740

tgctcatgcc tgctgagaca gttgtgtttt gcttgctctg cacacaccct gcatacttgc     7800

ctccaccctg gcccttcctc taccttgcca gtttcctcct tgtgtgtgaa ctcagtcagg     7860

cttacaacag acagagtatg aacatgcgat tcctccagct acttctagat atatggctga     7920

aagcttgc                                                              7928


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLSG

<400>  13

Gly Leu Ser Gly 
1               


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker - GGGGS

<400>  14

Gly Leu Ser Gly Ser Gly 
1               5       


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker - GLSGLSGS

<400>  15

Gly Leu Ser Gly Leu Ser Gly Ser 
1               5               


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLSGLSGLSG linker

<400>  16

Gly Leu Ser Gly Leu Ser Gly Leu Ser Gly 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLSGGSGLSG

<400>  17

Gly Leu Ser Gly Gly Ser Gly Leu Ser Gly 
1               5                   10  


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' detect VH1-69 FR3

<400>  18
acagaagttc cagggcagag                                                   20


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' up detect spec

<400>  19
tgtccactgg gttcgtgcct t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' down detect spec

<400>  20
cagtatcagc ccgtcatact t                                                 21


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' VH1-69 overlap detect

<400>  21
taacccctgt catctcctc                                                    19


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' DNA Target(PAM)

<400>  22
ggatcctggt ttagttaaag agg                                               23


<210>  23
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5' VH1-69 Cas9 crRNA

<400>  23
ggauccuggu uuaguuaaag guuuuagagc uaugcuguuu ug                          42


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' DNA Target(PAM)

<400>  24
gacaaaaacc ctgagggaga agg                                               23


<210>  25
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3 VH1-69 Cas9 crRNA

<400>  25
gacaaaaacc cugagggaga guuuuagagc uaugcuguuu ug                          42


<210>  26
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' up detect VH1-69

<400>  26
ctgtgaaata ccctgcctc                                                    19


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' up detect spec

<400>  27
tgtccactgg gttcgtgcct t                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' down detect spec

<400>  28
cagtatcagc ccgtcatact t                                                 21


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'down detect M1116(h70)

<400>  29
ccccctcttg ctctctttct                                                   20


<210>  30
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH1-69 MreI del Joiner Oligo

<400>  30
gtgaaaaccc acatcctgag agtgacaaaa accctgaggg agaaggcagc tgtgccgggc       60

tgaggagatg acaggggtta                                                   80


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' detect VH1-69 FR3

<400>  31
acagaagttc cagggcagag                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'down detect M1116(h70)

<400>  32
ccccctcttg ctctctttct                                                   20


