                         SEQUENCE LISTING

<110>  Columbia University in the City of New York
 
<120>  COMPOSITIONS AND METHODS FOR TREATING PATIENTS WITH
       MITOCHONDRIAL COMPLEX I DEFICIENCEY WITH CASPASE-9
       SIGNALING PATHWAY INHIBITORS

<130>  210271.41101WO

<140>  PCT
<141>  2021-12-14

<150>  US 63/129,197
<151>  2020-12-22

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide inhibitor of caspase-9 is XBIR3 

<400>  1

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Thr Asn Thr Cys Leu Pro Arg Asn Pro Ser 
            20                  25                  30          


Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr 
        35                  40                  45              


Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp 
    50                  55                  60                  


Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly Gly Gly 
65                  70                  75                  80  


Leu Arg Pro Ser Glu Asp Pro Trp Glu Gln His Ala Arg Trp Tyr Pro 
                85                  90                  95      


Gly Cys Arg Tyr Leu Leu Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn 
            100                 105                 110         


Ile His Leu Thr His Ser 
        115             


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide inhibitor of caspase-9 is XBIR3 

<400>  2

Met Gly Ser Ser Ser Ser Gly Leu Val Pro Arg Gly Ser His Met Ser 
1               5                   10                  15      


Thr Asn Thr Cys Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala 
            20                  25                  30          


Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln 
        35                  40                  45              


Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp Ala Leu Gly Glu Gly Asp 
    50                  55                  60                  


Lys Val Lys Cys Phe His Cys Gly Gly Gly Leu Arg Pro Ser Glu Asp 
65                  70                  75                  80  


Pro Trp Glu Gln His Ala Arg Trp Tyr Pro Gly Cys Arg Tyr Leu Leu 
                85                  90                  95      


Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser 
            100                 105                 110         


<210>  3
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide inhibitor of caspase-9 is XBIR3 

<400>  3

Ser Ser Gly Leu Val Pro Arg Gly Ser His Met Ser Thr Asn Thr Cys 
1               5                   10                  15      


Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr 
            20                  25                  30          


Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala 
        35                  40                  45              


Gly Phe Tyr Thr Asp Trp Ala Leu Gly Glu Gly Asp Lys Val Lys Cys 
    50                  55                  60                  


Phe His Cys Gly Gly Gly Leu Arg Pro Ser Glu Asp Pro Trp Glu Gln 
65                  70                  75                  80  


His Ala Arg Trp Tyr Pro Gly Cys Arg Tyr Leu Leu Glu Gln Arg Gly 
                85                  90                  95      


Gln Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser 
            100                 105             


<210>  4
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide inhibitor of caspase-9 is XBIR3 

<400>  4

Met Ser Thr Asn Thr Cys Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr 
1               5                   10                  15      


Glu Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys 
            20                  25                  30          


Glu Gln Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp Ala Leu Gly Glu 
        35                  40                  45              


Gly Asp Lys Val Lys Cys Phe His Cys Gly Gly Gly Leu Arg Pro Ser 
    50                  55                  60                  


Glu Asp Pro Trp Glu Gln His Ala Arg Trp Tyr Pro Gly Cys Arg Tyr 
65                  70                  75                  80  


Leu Leu Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn Ile His Leu Thr 
                85                  90                  95      


His Ser 
        


<210>  5
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide inhibitor of caspase-9 is XBIR3 

<400>  5

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Thr Asn Thr Leu Pro Arg Asn Pro Ser Met 
            20                  25                  30          


Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser 
        35                  40                  45              


Val Asn Lys Glu Gln Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp Ala 
    50                  55                  60                  


Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly Gly Gly Leu 
65                  70                  75                  80  


Arg Pro Ser Glu Asp Pro Trp Glu Gln His Ala Arg Trp Tyr Pro Gly 
                85                  90                  95      


Cys Arg Tyr Leu Leu Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn Ile 
            100                 105                 110         


His Leu Thr His Ser 
        115         


<210>  6
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide inhibitor of caspase-9 is XBIR3 

<400>  6

Met Gly Ser Ser Ser Ser Gly Leu Val Pro Arg Gly Ser His Met Ser 
1               5                   10                  15      


Thr Asn Thr Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg 
            20                  25                  30          


Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu 
        35                  40                  45              


Ala Arg Ala Gly Phe Tyr Thr Asp Trp Ala Leu Gly Glu Gly Asp Lys 
    50                  55                  60                  


Val Lys Cys Phe His Cys Gly Gly Gly Leu Arg Pro Ser Glu Asp Pro 
65                  70                  75                  80  


Trp Glu Gln His Ala Arg Trp Tyr Pro Gly Cys Arg Tyr Leu Leu Glu 
                85                  90                  95      


Gln Arg Gly Gln Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser 
            100                 105                 110     


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide inhibitor of caspase-9 is XBIR3

<400>  7

Ser Ser Gly Leu Val Pro Arg Gly Ser His Met Ser Thr Asn Thr Leu 
1               5                   10                  15      


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            20                  25                  30          


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        35                  40                  45              


Phe Tyr Thr Asp Trp Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe 
    50                  55                  60                  


His Cys Gly Gly Gly Leu Arg Pro Ser Glu Asp Pro Trp Glu Gln His 
65                  70                  75                  80  


Ala Arg Trp Tyr Pro Gly Cys Arg Tyr Leu Leu Glu Gln Arg Gly Gln 
                85                  90                  95      


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser 
            100                 105         


<210>  8
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide inhibitor of caspase-9 is XBIR3 

<400>  8

Met Ser Thr Asn Thr Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu 
1               5                   10                  15      


Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu 
            20                  25                  30          


Gln Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp Ala Leu Gly Glu Gly 
        35                  40                  45              


Asp Lys Val Lys Cys Phe His Cys Gly Gly Gly Leu Arg Pro Ser Glu 
    50                  55                  60                  


Asp Pro Trp Glu Gln His Ala Arg Trp Tyr Pro Gly Cys Arg Tyr Leu 
65                  70                  75                  80  


Leu Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn Ile His Leu Thr His 
                85                  90                  95      


Ser 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell-penetrating peptide of the membrane-permeable 
       complex is Penetratin1

<220>
<221> mod_res
<222> 1-2
<223> NPys

<400>  9

Cys Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys 
    


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell permeant molecule: RL16 
       a sequence derived from Penetratin1 

<400>  10

Arg Arg Leu Arg Arg Leu Leu Arg Arg Leu Leu Arg Arg Leu Arg Arg 
1               5                   10                  15      


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell permeant molecule - rabies virus 
       sequence which targets neurons

<400>  11

Arg Val Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10          


<210>  12
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  12

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - amino acid sequence included in 
       pIsl 

<400>  13

Pro Val Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys 
1               5                   10                  15      


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - small Tat fragment

<400>  14

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - amino acid sequence included in pVEC 

<400>  15

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


<210>  16
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - amino acid sequence included in MPS 

<400>  16

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - exemplary MAP sequence

<400>  17

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  18
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence caspase-9 signaling pathway inhibitor 
       comprising XBIR3 conjugated to a cell-penetrating peptide

<220>
<221> mod_res
<222> 1-2
<223> NPys

<220>
<221> mod_res
<222> 17-18
<223> disulfide bond

<400>  18

Cys Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val 
            20                  25                  30          


Pro Arg Gly Ser His Met Ser Thr Asn Thr Cys Leu Pro Arg Asn Pro 
        35                  40                  45              


Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile 
    50                  55                  60                  


Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly Phe Tyr Thr Asp 
65                  70                  75                  80  


Trp Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly Gly 
                85                  90                  95      


Gly Leu Arg Pro Ser Glu Asp Pro Trp Glu Gln His Ala Arg Trp Tyr 
            100                 105                 110         


Pro Gly Cys Arg Tyr Leu Leu Glu Gln Arg Gly Gln Glu Tyr Ile Asn 
        115                 120                 125             


Asn Ile His Leu Thr His Ser 
    130                 135 


<210>  19
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence caspase-9 signaling pathway inhibitor 
       comprising XBIR3 conjugated to a cell-penetrating peptide

<220>
<221> mod_res
<222> 1-2
<223> NPys

<220>
<221> mod_res
<222> 17-18
<223> disulfide bond

<400>  19

Cys Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys Met Gly Ser Ser Ser Ser Gly Leu Val Pro Arg Gly Ser His Met 
            20                  25                  30          


Ser Thr Asn Thr Cys Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu 
        35                  40                  45              


Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu 
    50                  55                  60                  


Gln Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp Ala Leu Gly Glu Gly 
65                  70                  75                  80  


Asp Lys Val Lys Cys Phe His Cys Gly Gly Gly Leu Arg Pro Ser Glu 
                85                  90                  95      


Asp Pro Trp Glu Gln His Ala Arg Trp Tyr Pro Gly Cys Arg Tyr Leu 
            100                 105                 110         


Leu Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn Ile His Leu Thr His 
        115                 120                 125             


Ser 
    

<210>  20
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence caspase-9 signaling pathway inhibitor 
       comprising XBIR3 conjugated to a cell-penetrating peptide

<220>
<221>  mod_res
<222>  1-2
<223>  NPys

<220>
<221>  mod_res
<222>  17-18
<223>  disulfide bond

<400>  20

Cys Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys Ser Ser Gly Leu Val Pro Arg Gly Ser His Met Ser Thr Asn Thr 
            20                  25                  30          


Cys Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe 
        35                  40                  45              


Thr Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg 
    50                  55                  60                  


Ala Gly Phe Tyr Thr Asp Trp Ala Leu Gly Glu Gly Asp Lys Val Lys 
65                  70                  75                  80  


Cys Phe His Cys Gly Gly Gly Leu Arg Pro Ser Glu Asp Pro Trp Glu 
                85                  90                  95      


Gln His Ala Arg Trp Tyr Pro Gly Cys Arg Tyr Leu Leu Glu Gln Arg 
            100                 105                 110         


Gly Gln Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser 
        115                 120                 125 


<210>  21
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence caspase-9 signaling pathway inhibitor 
       comprising XBIR3 conjugated to a cell-penetrating peptide

<220>
<221>  mod_res
<222>  1
<223>  NPys

<220>
<221>  mod_res
<222>  16-17
<223>  disulfide bond


<400>  21

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Met Ser Thr Asn Thr Cys Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr 
            20                  25                  30          


Glu Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys 
        35                  40                  45              


Glu Gln Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp Ala Leu Gly Glu 
    50                  55                  60                  


Gly Asp Lys Val Lys Cys Phe His Cys Gly Gly Gly Leu Arg Pro Ser 
65                  70                  75                  80  


Glu Asp Pro Trp Glu Gln His Ala Arg Trp Tyr Pro Gly Cys Arg Tyr 
                85                  90                  95      


Leu Leu Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn Ile His Leu Thr 
            100                 105                 110         


His Ser 
        


<210>  22
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence caspase-9 signaling pathway inhibitor 
       comprising XBIR3 conjugated to a cell-penetrating peptide

<220>
<221>  mod_res
<222>  1-2
<223>  NPys

<220>
<221>  mod_res
<222>  17-18
<223>  disulfide bond


<400>  22

Cys Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val 
            20                  25                  30          


Pro Arg Gly Ser His Met Ser Thr Asn Thr Leu Pro Arg Asn Pro Ser 
        35                  40                  45              


Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr 
    50                  55                  60                  


Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp 
65                  70                  75                  80  


Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly Gly Gly 
                85                  90                  95      


Leu Arg Pro Ser Glu Asp Pro Trp Glu Gln His Ala Arg Trp Tyr Pro 
            100                 105                 110         


Gly Cys Arg Tyr Leu Leu Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn 
        115                 120                 125             


Ile His Leu Thr His Ser 
    130                 


<210>  23
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence caspase-9 signaling pathway inhibitor 
       comprising XBIR3 conjugated to a cell-penetrating peptide

<220>
<221>  mod_res
<222>  1-2
<223>  NPys

<220>
<221>  mod_res
<222>  17-18
<223>  disulfide bond

<400>  23

Cys Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys Met Gly Ser Ser Ser Ser Gly Leu Val Pro Arg Gly Ser His Met 
            20                  25                  30          


Ser Thr Asn Thr Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala 
        35                  40                  45              


Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln 
    50                  55                  60                  


Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp Ala Leu Gly Glu Gly Asp 
65                  70                  75                  80  


Lys Val Lys Cys Phe His Cys Gly Gly Gly Leu Arg Pro Ser Glu Asp 
                85                  90                  95      


Pro Trp Glu Gln His Ala Arg Trp Tyr Pro Gly Cys Arg Tyr Leu Leu 
            100                 105                 110         


Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser 
        115                 120                 125             


<210>  24
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence caspase-9 signaling pathway inhibitor 
       comprising XBIR3 conjugated to a cell-penetrating peptide

<220>
<221>  mod_res
<222>  1-2
<223>  NPys

<220>
<221>  mod_res
<222>  17-18
<223>  disulfide bond

<400>  24

Cys Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys Ser Ser Gly Leu Val Pro Arg Gly Ser His Met Ser Thr Asn Thr 
            20                  25                  30          


Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr 
        35                  40                  45              


Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala 
    50                  55                  60                  


Gly Phe Tyr Thr Asp Trp Ala Leu Gly Glu Gly Asp Lys Val Lys Cys 
65                  70                  75                  80  


Phe His Cys Gly Gly Gly Leu Arg Pro Ser Glu Asp Pro Trp Glu Gln 
                85                  90                  95      


His Ala Arg Trp Tyr Pro Gly Cys Arg Tyr Leu Leu Glu Gln Arg Gly 
            100                 105                 110         


Gln Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser 
        115                 120                 


<210>  25
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence caspase-9 signaling pathway inhibitor 
       comprising XBIR3 conjugated to a cell-penetrating peptide

<220>
<221>  mod_res
<222>  1-2
<223>  NPys

<220>
<221>  mod_res
<222>  17-18
<223>  disulfide bond

<400>  25

Cys Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys Met Ser Thr Asn Thr Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr 
            20                  25                  30          


Glu Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys 
        35                  40                  45              


Glu Gln Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp Ala Leu Gly Glu 
    50                  55                  60                  


Gly Asp Lys Val Lys Cys Phe His Cys Gly Gly Gly Leu Arg Pro Ser 
65                  70                  75                  80  


Glu Asp Pro Trp Glu Gln His Ala Arg Trp Tyr Pro Gly Cys Arg Tyr 
                85                  90                  95      


Leu Leu Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn Ile His Leu Thr 
            100                 105                 110         


His Ser 
        


