<110>    LG CHEM, LTD.

<120>    Polypeptide specific to Mucin1 and use thereof

<130>    OPP20215468KR

<150>    KR10-2020-0183768
<151>    2020-12-24

<150>    KR10-2021-0137757
<151>    2021-10-15

<160>    115

<170>    koPatentIn 3.0

<210>    1
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2445_1F09 HCDR1


<400>    1
Gly Phe Thr Val Ser Ser Asn Tyr
  1               5            


<210>    2
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2445_1F09 HCDR2


<400>    2
Ile Tyr Ser Gly Gly Ser Thr
  1               5        


<210>    3
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2445_1F09 HCDR3


<400>    3
Asp Arg Gly Trp Asn His Gly Met Asp Val
  1               5                  10


<210>    4
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2445_1F09 LCDR1


<400>    4
Ser Ser Glu Val Gly Ser Arg Tyr
  1               5            


<210>    5
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2445_1F09 LCDR2


<400>    5
Lys Asn Asp
  1        


<210>    6
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2445_1F09 LCDR3


<400>    6
Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val
  1               5                  10    


<210>    7
<211>    118
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2445_1F09 VH


<400>    7
Glu Val Gln Leu Leu Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
             20                  25                  30 

Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
     50                  55                  60 

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
 65                  70                  75                  80 

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                 85                  90                  95 

Arg Asp Arg Gly Trp Asn His Gly Met Asp Val Trp Gly Gln Gly Thr
            100                 105                 110 

Leu Val Thr Val Ser Ser
        115            


<210>    8
<211>    110
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2445_1F09 VL


<400>    8
Gln Ser Gly Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Glu Val Gly Ser Arg
             20                  25                  30 

Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu
         35                  40                  45 

Ile Tyr Lys Asn Asp Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu
            100                 105                 110


<210>    9
<211>    243
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2445_1F09 scFv


<400>    9
Glu Val Gln Leu Leu Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
             20                  25                  30 

Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
     50                  55                  60 

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
 65                  70                  75                  80 

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                 85                  90                  95 

Arg Asp Arg Gly Trp Asn His Gly Met Asp Val Trp Gly Gln Gly Thr
            100                 105                 110 

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125 

Gly Gly Gly Ala Ser Gln Ser Gly Leu Thr Gln Pro Pro Ser Ala Ser
    130                 135                 140 

Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser
145                 150                 155                 160 

Glu Val Gly Ser Arg Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr
                165                 170                 175 

Ala Pro Arg Leu Leu Ile Tyr Lys Asn Asp Arg Arg Pro Ser Gly Val
            180                 185                 190 

Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala
        195                 200                 205 

Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala
    210                 215                 220 

Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu
225                 230                 235                 240 

Thr Val Leu
           


<210>    10
<211>    729
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    2445_1F09 scFv


<400>    10
gaggtgcagc tgttggagac tggaggaggc ttgatccagc ctggggggtc cctgagactc         60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct        120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atattacgca        180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt        240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatcgcggc        300

tggaaccacg gtatggacgt ctggggccag ggaaccctgg tcaccgtctc gagtggtgga        360

ggcggttcag gcggaggtgg ctctggcggt ggcgctagcc agtctgggct gactcagcca        420

ccctcagcgt ctgggacccc cgggcagagg gtcaccatct cttgttctgg gggcagctca        480

gaagtcggaa gtagatatgt gtcctggtac cagcaactcc caggaacggc ccccagactc        540

ctcatctata agaatgatcg gcggccctca ggggtccctg accgattctc tggctccaag        600

tctggctcct cagcctccct ggccatcagt gggctccggt ccgaggatga ggctgattat        660

tactgtgcag catgggatga cagcctgaat ggttatgtct tcggaactgg gaccaagctg        720

accgtccta                                                                729


<210>    11
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_2H08 HCDR1


<400>    11
Gly Tyr Thr Phe Thr Asn Tyr Gly
  1               5            


<210>    12
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_2H08 HCDR2


<400>    12
Ile Ser Ala Tyr Asn Gly Asn Thr
  1               5            


<210>    13
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_2H08 HCDR3


<400>    13
Asp Pro His Ile Leu Thr Gly Tyr Tyr Arg Gly Gly Trp Phe Asp Pro
  1               5                  10                  15 




<210>    14
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_2H08 LCDR1


<400>    14
Ser Leu Arg Thr Ser Tyr
  1               5    


<210>    15
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_2H08 LCDR2


<400>    15
Gly Lys Thr
  1        


<210>    16
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_2H08 LCDR3


<400>    16
His Ser Arg Asp Ser Asn Asp Asn Tyr Leu Glu Val Val
  1               5                  10            


<210>    17
<211>    125
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_2H08 VH


<400>    17
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
             20                  25                  30 

Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
     50                  55                  60 

Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Pro His Ile Leu Thr Gly Tyr Tyr Arg Gly Gly Trp Phe
            100                 105                 110 

Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125


<210>    18
<211>    110
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_2H08 VL


<400>    18
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
  1               5                  10                  15 

Thr Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Ser Tyr Ala
             20                  25                  30 

Gly Trp Leu Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Leu Tyr
         35                  40                  45 

Gly Lys Thr Ser Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
     50                  55                  60 

Thr Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
 65                  70                  75                  80 

Asp Glu Ala Glu Tyr Phe Cys His Ser Arg Asp Ser Asn Asp Asn Tyr
                 85                  90                  95 

Leu Glu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110


<210>    19
<211>    250
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_2H08 scFv


<400>    19
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
             20                  25                  30 

Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
     50                  55                  60 

Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Pro His Ile Leu Thr Gly Tyr Tyr Arg Gly Gly Trp Phe
            100                 105                 110 

Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
        115                 120                 125 

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Ser Tyr Glu Leu
    130                 135                 140 

Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Thr Ile
145                 150                 155                 160 

Thr Cys Gln Gly Asp Ser Leu Arg Thr Ser Tyr Ala Gly Trp Leu Gln
                165                 170                 175 

Gln Lys Pro Gly Gln Ala Pro Val Leu Val Leu Tyr Gly Lys Thr Ser
            180                 185                 190 

Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asn
        195                 200                 205 

Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Glu
    210                 215                 220 

Tyr Phe Cys His Ser Arg Asp Ser Asn Asp Asn Tyr Leu Glu Val Val
225                 230                 235                 240 

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                245                 250


<210>    20
<211>    750
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    2447_2H08 scFv


<400>    20
gaagtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc         60

tcctgcaagg cttctggtta cacctttacc aactacggta tcagctgggt gcgacaggcc        120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat        180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac        240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatccg        300

catattttga ctggttatta taggggaggg tggttcgacc cctgggggca agggaccacg        360

gtcaccgtct cgagtggtgg aggcggttca ggcggaggtg gctctggcgg tggcgctagc        420

tcctatgagc tgactcagga ccctgctgtg tctgtggcct tgggtcagac agtcaccatc        480

acgtgccaag gagacagcct cagaacctct tatgcaggct ggctccagca gaagccagga        540

caggcccctg tactcgtcct ctatggtaaa accagccggc cctcagggat cccagaccga        600

ttctctggct ccacctcagg aaacacagct tccttgacca tcactggggc tcaggcggag        660

gatgaggctg agtatttctg tcactcccgg gacagcaatg ataactatct agaggtggtt        720

ttcggcggag ggaccaagct gaccgtccta                                         750


<210>    21
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A01 HCDR1


<400>    21
Gly Phe Thr Phe Asp Asp Tyr Ala
  1               5            


<210>    22
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A01 HCDR2


<400>    22
Ile Ser Trp Asn Ser Gly Ser Ile
  1               5            


<210>    23
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A01 HCDR3


<400>    23
Asp Ile Ser Ser Gly Trp Tyr Pro Gly Thr Phe Asp Tyr
  1               5                  10            


<210>    24
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A01 LCDR1


<400>    24
Ser Leu Arg Ser Tyr Tyr
  1               5    


<210>    25
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A01 LCDR2


<400>    25
Gly Lys Asn
  1        


<210>    26
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A01 LCDR3


<400>    26
Ser Ser Arg Asp Ser Ser Asp Asp Val Val
  1               5                  10


<210>    27
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A01 VH


<400>    27
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Val Tyr Ala Asp Phe Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Ile Ser Ser Gly Trp Tyr Pro Gly Thr Phe Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120        


<210>    28
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A01 VL


<400>    28
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
  1               5                  10                  15 

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
             20                  25                  30 

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
         35                  40                  45 

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
     50                  55                  60 

Ser Ser Gly Asn Thr Ala Ser Leu Thr Val Thr Gly Ala Gln Ala Glu
 65                  70                  75                  80 

Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Asp Asp Val
                 85                  90                  95 

Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu
            100                 105        


<210>    29
<211>    244
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A01 scFv


<400>    29
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Val Tyr Ala Asp Phe Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Ile Ser Ser Gly Trp Tyr Pro Gly Thr Phe Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
        115                 120                 125 

Gly Gly Gly Ser Gly Gly Gly Ala Ser Ser Tyr Glu Leu Thr Gln Asp
    130                 135                 140 

Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln
145                 150                 155                 160 

Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro
                165                 170                 175 

Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser
            180                 185                 190 

Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser
        195                 200                 205 

Leu Thr Val Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
    210                 215                 220 

Ser Ser Arg Asp Ser Ser Asp Asp Val Val Phe Gly Gly Gly Thr Gln
225                 230                 235                 240 

Leu Thr Val Leu
               


<210>    30
<211>    732
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    2447_3A01 scFv


<400>    30
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc         60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct        120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag catagtctat        180

gcggactttg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat        240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatatt        300

tcaagtggct ggtacccagg gacctttgac tactggggcc agggaaccct ggtcaccgtc        360

tcgagtggtg gaggcggttc aggcggaggt ggctctggcg gtggcgctag ctcctatgag        420

ctgactcagg accctgctgt gtctgtggcc ttgggacaga cagtcaggat cacatgccaa        480

ggagacagcc tcagaagcta ttatgcaagc tggtaccagc agaagccagg acaggcccct        540

gtacttgtca tctatggtaa aaacaaccgg ccctcaggga tcccagaccg attctctggc        600

tccagctcag gaaacacagc ttccttgacc gtcactgggg ctcaggcgga agacgaggct        660

gactattact gtagctcccg ggacagcagt gatgatgtgg tattcggcgg agggacccag        720

ctcaccgtcc ta                                                            732


<210>    31
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A08 HCDR1


<400>    31
Gly Tyr Thr Phe Thr Ser Tyr Gly
  1               5            


<210>    32
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A08 HCDR2


<400>    32
Ile Ser Ala Tyr Asn Gly Asn Thr
  1               5            


<210>    33
<211>    14
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A08 HCDR3


<400>    33
Asp Arg Ala Thr Ile Phe Gly Val Val Thr Pro Phe Asp Tyr
  1               5                  10                


<210>    34
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A08 LCDR1


<400>    34
Ser Ile Arg Ser Tyr Ser
  1               5    


<210>    35
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A08 LCDR2


<400>    35
Gly Lys Asn
  1        


<210>    36
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A08 LCDR3


<400>    36
Asn Ser Arg Asp Ser Ser Gly Asn Arg Val Val
  1               5                  10    


<210>    37
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A08 VH


<400>    37
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
     50                  55                  60 

Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Arg Ala Thr Ile Phe Gly Val Val Thr Pro Phe Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120            


<210>    38
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A08 VL


<400>    38
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
  1               5                  10                  15 

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Ile Arg Ser Tyr Ser Ala
             20                  25                  30 

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr
         35                  40                  45 

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Val Ser Gly Ser
     50                  55                  60 

Thr Ser Gly Asn Thr Ala Ser Leu Thr Val Thr Gly Ala Gln Ala Glu
 65                  70                  75                  80 

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Arg
                 85                  90                  95 

Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu
            100                 105            


<210>    39
<211>    246
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A08 scFv


<400>    39
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
     50                  55                  60 

Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Arg Ala Thr Ile Phe Gly Val Val Thr Pro Phe Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
        115                 120                 125 

Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Ser Tyr Glu Leu Thr Gln
    130                 135                 140 

Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys
145                 150                 155                 160 

Gln Gly Asp Ser Ile Arg Ser Tyr Ser Ala Ser Trp Tyr Gln Gln Lys
                165                 170                 175 

Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro
            180                 185                 190 

Ser Gly Ile Pro Asp Arg Val Ser Gly Ser Thr Ser Gly Asn Thr Ala
        195                 200                 205 

Ser Leu Thr Val Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr
    210                 215                 220 

Cys Asn Ser Arg Asp Ser Ser Gly Asn Arg Val Val Phe Gly Gly Gly
225                 230                 235                 240 

Thr Gln Leu Thr Val Leu
                245    


<210>    40
<211>    738
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    2447_3A08 scFv


<400>    40
gaagtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc         60

tcctgcaagg cttctggtta cacctttacc agctacggta tcagctgggt gcgacaggcc        120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat        180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac        240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatcgg        300

gctacgattt ttggagtggt tacccccttt gactactggg gccaaggaac cctggtcacc        360

gtctcgagtg gtggaggcgg ttcaggcgga ggtggctctg gcggtggcgc tagctcctat        420

gagctgactc aggaccccgc tgtgtctgtg gccttgggac agacagtcag gatcacatgc        480

cagggagaca gtattagaag ttattctgcc agctggtacc agcagaagcc agggcaggcc        540

cctcgccttg ttatctatgg taaaaacaac cggccctcag ggatcccaga ccgagtctct        600

ggctccactt caggaaatac agcttccttg accgtcactg gggctcaggc ggaagatgag        660

gctgactatt actgtaactc ccgggacagc agtggtaacc gtgtggtatt cggcggaggg        720

acccagctca ccgtccta                                                      738


<210>    41
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A09 HCDR1


<400>    41
Gly Phe Thr Phe Asp Asp Tyr Ala
  1               5            


<210>    42
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A09 HCDR2


<400>    42
Ile Ser Trp Asn Ser Gly Ser Ile
  1               5            


<210>    43
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A09 HCDR3


<400>    43
Asp Val Ser Ser Gly Trp Tyr Trp Tyr Ala Phe Asp Ile
  1               5                  10            


<210>    44
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A09 LCDR1


<400>    44
Ser Leu Arg Ser Tyr Tyr
  1               5    


<210>    45
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A09 LCDR2


<400>    45
Gly Lys Asn
  1        


<210>    46
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A09 LCDR3


<400>    46
Asn Ser Arg Asp Ser Gly Gly Ser Val Val
  1               5                  10


<210>    47
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A09 VH


<400>    47
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ser Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Val Ser Ser Gly Trp Tyr Trp Tyr Ala Phe Asp Ile Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120        


<210>    48
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A09 VL


<400>    48
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
  1               5                  10                  15 

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
             20                  25                  30 

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
         35                  40                  45 

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Gly Arg Phe Ser Gly Ser
     50                  55                  60 

Ser Ser Gly Asn Thr Ala Ser Leu Thr Val Thr Gly Ala Gln Ala Glu
 65                  70                  75                  80 

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Gly Gly Ser Val
                 85                  90                  95 

Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105        


<210>    49
<211>    244
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A09 scFv


<400>    49
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ser Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Val Ser Ser Gly Trp Tyr Trp Tyr Ala Phe Asp Ile Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
        115                 120                 125 

Gly Gly Gly Ser Gly Gly Gly Ala Ser Ser Tyr Glu Leu Thr Gln Asp
    130                 135                 140 

Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln
145                 150                 155                 160 

Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro
                165                 170                 175 

Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser
            180                 185                 190 

Gly Ile Pro Gly Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser
        195                 200                 205 

Leu Thr Val Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
    210                 215                 220 

Asn Ser Arg Asp Ser Gly Gly Ser Val Val Phe Gly Gly Gly Thr Lys
225                 230                 235                 240 

Leu Thr Val Leu
               


<210>    50
<211>    732
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    2447_3A09 scFv


<400>    50
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc         60

tcctgtgcag ccactggatt cacctttgat gattatgcca tgcactgggt ccggcaagct        120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat        180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat        240

ctgcaaatga acagtctgag agctgaggac acggcctcgt attactgtgc aaaagatgtt        300

agcagtggct ggtactggta tgcttttgat atctggggcc aaggaaccct ggtcaccgtc        360

tcgagtggtg gaggcggttc aggcggaggt ggctctggcg gtggcgctag ctcctatgag        420

ctgactcagg accctgctgt gtctgtggcc ttgggacaga cagtcaggat cacatgccaa        480

ggagacagcc tcagaagcta ttatgcaagc tggtaccagc agaagccagg acaggcccct        540

gtacttgtca tctatggtaa aaacaaccgg ccctcaggga tcccaggccg attctctggc        600

tccagctcag gaaacacagc ttccttgacc gtcactgggg ctcaggcgga agatgaggct        660

gactattact gtaattcccg ggacagcggt ggttctgtgg ttttcggcgg agggaccaag        720

ctgaccgtcc ta                                                            732


<210>    51
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A12 HCDR1


<400>    51
Gly Tyr Thr Phe Thr Ser Tyr Gly
  1               5            


<210>    52
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A12 HCDR2


<400>    52
Ile Ser Ala Tyr Asn Gly Asn Thr
  1               5            


<210>    53
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A12 HCDR3


<400>    53
Asp Pro His Ile Leu Thr Gly Tyr Tyr Arg Gly Gly Trp Phe Asp Pro
  1               5                  10                  15 




<210>    54
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A12 LCDR1


<400>    54
Ser Leu Arg Ser Tyr Tyr
  1               5    


<210>    55
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A12 LCDR2


<400>    55
Gly Lys Asn
  1        


<210>    56
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A12 LCDR3


<400>    56
Asn Ser Arg Asp Ser Ser Gly Asn His Arg Val
  1               5                  10    


<210>    57
<211>    125
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A12 VH


<400>    57
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
     50                  55                  60 

Arg Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Pro His Ile Leu Thr Gly Tyr Tyr Arg Gly Gly Trp Phe
            100                 105                 110 

Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125


<210>    58
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A12 VL


<400>    58
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Val Leu Gly Gln
  1               5                  10                  15 

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
             20                  25                  30 

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
         35                  40                  45 

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
     50                  55                  60 

Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
 65                  70                  75                  80 

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His
                 85                  90                  95 

Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105            


<210>    59
<211>    248
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3A12 scFv


<400>    59
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
     50                  55                  60 

Arg Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Pro His Ile Leu Thr Gly Tyr Tyr Arg Gly Gly Trp Phe
            100                 105                 110 

Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
        115                 120                 125 

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Ser Tyr Glu Leu
    130                 135                 140 

Thr Gln Asp Pro Ala Val Ser Val Val Leu Gly Gln Thr Val Arg Ile
145                 150                 155                 160 

Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln
                165                 170                 175 

Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn
            180                 185                 190 

Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn
        195                 200                 205 

Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp
    210                 215                 220 

Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Arg Val Phe Gly
225                 230                 235                 240 

Gly Gly Thr Lys Leu Thr Val Leu
                245            


<210>    60
<211>    744
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    2447_3A12 scFv


<400>    60
gaagtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc         60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc        120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat        180

gcacagaagc tccggggcag agtcaccatg accacagaca catccacgag cacagcctac        240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatccg        300

catattttga ctggttatta taggggaggg tggttcgacc cctggggcca gggcaccctg        360

gtcaccgtct cgagtggtgg aggcggttca ggcggaggtg gctctggcgg tggcgctagc        420

tcctatgagc tgactcagga ccctgctgtg tctgtggtct tgggacagac agtcaggatc        480

acatgccaag gagacagcct cagaagctat tatgcaagct ggtaccagca gaagccagga        540

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga        600

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa        660

gatgaggctg actattactg taactcccgg gacagcagtg gtaaccatcg tgtattcggc        720

ggagggacca agctgaccgt ccta                                               744


<210>    61
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3B07 HCDR1


<400>    61
Gly Phe Thr Phe Asp Asp Tyr Ala
  1               5            


<210>    62
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3B07 HCDR2


<400>    62
Thr Ser Trp Asp Gly Gly Ser Thr
  1               5            


<210>    63
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3B07 HCDR3


<400>    63
Asp His Ser Ser Gly Trp Tyr Asn Gly Gly
  1               5                  10


<210>    64
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3B07 LCDR1


<400>    64
Ser Leu Arg Ser Tyr Tyr
  1               5    


<210>    65
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3B07 LCDR2


<400>    65
Gly Lys Asn
  1        


<210>    66
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3B07 LCDR3


<400>    66
Asn Ser Arg Asp Ser Ser Gly Asn His Val Val
  1               5                  10    


<210>    67
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3B07 VH


<400>    67
Gln Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val
         35                  40                  45 

Ser Leu Thr Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp His Ser Ser Gly Trp Tyr Asn Gly Gly Met Asp Val Trp
            100                 105                 110 

Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120        


<210>    68
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3B07 VL


<400>    68
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
  1               5                  10                  15 

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
             20                  25                  30 

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
         35                  40                  45 

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
     50                  55                  60 

Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
 65                  70                  75                  80 

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His
                 85                  90                  95 

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105            


<210>    69
<211>    245
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3B07 scFv


<400>    69
Gln Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val
         35                  40                  45 

Ser Leu Thr Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp His Ser Ser Gly Trp Tyr Asn Gly Gly Met Asp Val Trp
            100                 105                 110 

Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
        115                 120                 125 

Gly Gly Gly Ser Gly Gly Gly Ala Ser Ser Tyr Glu Leu Thr Gln Asp
    130                 135                 140 

Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln
145                 150                 155                 160 

Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro
                165                 170                 175 

Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser
            180                 185                 190 

Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser
        195                 200                 205 

Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
    210                 215                 220 

Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly Gly Thr
225                 230                 235                 240 

Lys Leu Thr Val Leu
                245


<210>    70
<211>    735
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    2447_3B07 scFv


<400>    70
caggtgcagc tggtggagtc tgggggagtc gtggtacagc ctggggggtc cctgagactc         60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagct        120

ccggggaggg gtctggagtg ggtctctctt actagttggg atggtggtag cacatactat        180

gcagactctg tgaagggtcg attcaccatc tccagagaca acagcaaaaa ctccctgtat        240

ctgcaaatga acagtctgag agctgaggac accgccttgt attactgtgc aaaagatcat        300

agcagcggct ggtacaacgg gggtatggac gtctggggcc aagggacaat ggtcaccgtc        360

tcgagtggtg gaggcggttc aggcggaggt ggctctggcg gtggcgctag ctcctatgag        420

ctgactcagg accctgctgt gtctgtggcc ttgggacaga cagtcaggat cacatgccaa        480

ggagacagcc tcagaagcta ttatgcaagc tggtaccagc agaagccagg acaggcccct        540

gtacttgtca tctatggtaa aaacaaccgg ccctcaggga tcccagaccg attctctggc        600

tccagctcag gaaacacagc ttccttgacc atcactgggg ctcaggcgga agatgaggct        660

gactattact gtaactcccg ggacagcagt ggtaaccatg tggtattcgg cggagggacc        720

aagctgaccg tccta                                                         735


<210>    71
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3C08 HCDR1


<400>    71
Gly Phe Thr Phe Asp Asp Tyr Ala
  1               5            


<210>    72
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3C08 HCDR2


<400>    72
Ile Ser Trp Asn Ser Gly Ser Ile
  1               5            


<210>    73
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3C08 HCDR3


<400>    73
Asp Arg Gly Ser Gly Tyr Glu Gly Asn Tyr Tyr Gly Met Asp Val
  1               5                  10                  15


<210>    74
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3C08 LCDR1


<400>    74
Ser Leu Arg Ser Tyr Tyr
  1               5    


<210>    75
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3C08 LCDR2


<400>    75
Gly Lys Asn
  1        


<210>    76
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3C08 LCDR3


<400>    76
Asn Ser Arg Asp Ser Ser Gly Asn His Tyr Val
  1               5                  10    


<210>    77
<211>    124
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3C08 VH


<400>    77
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Arg Gly Ser Gly Tyr Glu Gly Asn Tyr Tyr Gly Met Asp
            100                 105                 110 

Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                


<210>    78
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3C08 VL


<400>    78
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
  1               5                  10                  15 

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
             20                  25                  30 

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
         35                  40                  45 

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Thr
     50                  55                  60 

Thr Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
 65                  70                  75                  80 

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His
                 85                  90                  95 

Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
            100                 105            


<210>    79
<211>    247
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3C08 scFv


<400>    79
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Arg Gly Ser Gly Tyr Glu Gly Asn Tyr Tyr Gly Met Asp
            100                 105                 110 

Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
        115                 120                 125 

Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Ser Tyr Glu Leu Thr
    130                 135                 140 

Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr
145                 150                 155                 160 

Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln
                165                 170                 175 

Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg
            180                 185                 190 

Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Thr Thr Ser Gly Asn Thr
        195                 200                 205 

Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr
    210                 215                 220 

Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Tyr Val Phe Gly Thr
225                 230                 235                 240 

Gly Thr Lys Val Thr Val Leu
                245        


<210>    80
<211>    741
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    2447_3C08 scFv


<400>    80
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc         60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct        120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat        180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat        240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatagg        300

ggtagtggct acgaaggaaa ctactacggt atggacgtct ggggccaagg aaccctggtc        360

accgtctcga gtggtggagg cggttcaggc ggaggtggct ctggcggtgg cgctagctcc        420

tatgagctga ctcaggaccc tgctgtgtct gtggccttgg gacagacagt caggatcaca        480

tgccaaggag acagcctcag aagctattat gcaagctggt accagcagaa gccaggacag        540

gcccctgtac ttgtcatcta tggtaaaaac aaccggccct cagggatccc agaccgattc        600

tctggtacca cctcaggaaa cacagcctcc ttgaccatca ctggggctca ggcggaagat        660

gaggctgact attactgtaa ctcccgggac agcagtggta accattatgt cttcggaact        720

gggaccaagg tcaccgtcct a                                                  741


<210>    81
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H02 HCDR1


<400>    81
Gly Phe Thr Phe Asp Asp Tyr Ala
  1               5            


<210>    82
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H02 HCDR2


<400>    82
Ile Ser Trp Asp Ser Gly Ser Ile
  1               5            


<210>    83
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H02 HCDR3


<400>    83
Asp Val Ser Ser Gly Trp Tyr Trp Tyr Ala Phe Asp Ile
  1               5                  10            


<210>    84
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H02 LCDR1


<400>    84
Ile Leu Arg Ser Tyr Tyr
  1               5    


<210>    85
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H02 LCDR2


<400>    85
Gly Lys Asn
  1        


<210>    86
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H02 LCDR3


<400>    86
Asn Ser Arg Asp Ser Ser Gly Asn Arg Val Val
  1               5                  10    


<210>    87
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H02 VH


<400>    87
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Trp Asp Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Val Ser Ser Gly Trp Tyr Trp Tyr Ala Phe Asp Ile Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120        


<210>    88
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H02 VL


<400>    88
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
  1               5                  10                  15 

Thr Val Arg Ile Thr Cys Gln Gly Asp Ile Leu Arg Ser Tyr Tyr Ala
             20                  25                  30 

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
         35                  40                  45 

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
     50                  55                  60 

Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
 65                  70                  75                  80 

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Arg
                 85                  90                  95 

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105            


<210>    89
<211>    245
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H02 scFv


<400>    89
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Trp Asp Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asp Val Ser Ser Gly Trp Tyr Trp Tyr Ala Phe Asp Ile Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
        115                 120                 125 

Gly Gly Gly Ser Gly Gly Gly Ala Ser Ser Tyr Glu Leu Thr Gln Asp
    130                 135                 140 

Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln
145                 150                 155                 160 

Gly Asp Ile Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro
                165                 170                 175 

Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser
            180                 185                 190 

Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser
        195                 200                 205 

Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
    210                 215                 220 

Asn Ser Arg Asp Ser Ser Gly Asn Arg Val Val Phe Gly Gly Gly Thr
225                 230                 235                 240 

Lys Leu Thr Val Leu
                245


<210>    90
<211>    735
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    2447_3H02 scFv


<400>    90
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc         60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct        120

ccagggaagg gcctggagtg ggtctcaggt attagttggg atagtggtag cataggctat        180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat        240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatgtt        300

agcagtggct ggtactggta tgcttttgat atctggggcc agggaaccct ggtcaccgtc        360

tcgagtggtg gaggcggttc aggcggaggt ggctctggcg gtggcgctag ctcctatgag        420

ctgactcagg accctgctgt gtctgtggcc ttgggacaga cagtcaggat cacatgccaa        480

ggagacatcc tcagaagtta ttatgcaagt tggtaccagc agaagccagg acaggcccct        540

gtacttgtca tttatggtaa aaacaaccgg ccctcaggga tcccagaccg attctctggc        600

tccagctcag gaaacacagc ttccttgacc atcactgggg ctcaggcgga agatgaggct        660

gactattact gtaactcccg ggacagcagt ggtaaccgtg tggtattcgg cggagggacc        720

aagctgaccg tccta                                                         735


<210>    91
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H08 HCDR1


<400>    91
Gly Phe Thr Phe Asp Asp Tyr Ala
  1               5            


<210>    92
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H08 HCDR2


<400>    92
Ile Ser Trp Asn Ser Gly Ser Ile
  1               5            


<210>    93
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H08 HCDR3


<400>    93
Asp Arg Ser Ser Gly Trp Tyr Thr Gly Ser Phe Asp Tyr
  1               5                  10            


<210>    94
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H08 LCDR1


<400>    94
Ser Leu Arg Ser Tyr Tyr
  1               5    


<210>    95
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H08 LCDR2


<400>    95
Gly Lys Asn
  1        


<210>    96
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H08 LCDR3


<400>    96
Gln Ser Arg Asp Ser Ser Asp Asn Arg Val Leu
  1               5                  10    


<210>    97
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H08 VH


<400>    97
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Asp Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Arg Ser Ser Gly Trp Tyr Thr Gly Ser Phe Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120        


<210>    98
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H08 VL


<400>    98
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
  1               5                  10                  15 

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
             20                  25                  30 

Ser Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
         35                  40                  45 

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
     50                  55                  60 

Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Ile Gly Ala Gln Ala Glu
 65                  70                  75                  80 

Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Arg Asp Ser Ser Asp Asn Arg
                 85                  90                  95 

Val Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu
            100                 105            


<210>    99
<211>    245
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    2447_3H08 scFv


<400>    99
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Asp Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Arg Ser Ser Gly Trp Tyr Thr Gly Ser Phe Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
        115                 120                 125 

Gly Gly Gly Ser Gly Gly Gly Ala Ser Ser Tyr Glu Leu Thr Gln Asp
    130                 135                 140 

Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln
145                 150                 155                 160 

Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Arg Gln Lys Pro
                165                 170                 175 

Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser
            180                 185                 190 

Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser
        195                 200                 205 

Leu Thr Ile Ile Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
    210                 215                 220 

Gln Ser Arg Asp Ser Ser Asp Asn Arg Val Leu Phe Gly Gly Gly Thr
225                 230                 235                 240 

Lys Val Thr Val Leu
                245


<210>    100
<211>    735
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    2447_3H08 scFv


<400>    100
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc         60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct        120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag catagactat        180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat        240

ctgcaaatga acagcctgag agctgaggac acagctgtgt actactgtgc gagagatcgg        300

agtagtggct ggtacacggg gtcctttgac tactggggcc agggcaccct ggtcaccgtc        360

tcgagtggtg gaggcggttc aggcggaggt ggctctggcg gtggcgctag ctcctatgag        420

ctgactcagg accctgctgt gtctgtggcc ttgggacaga cagtcaggat cacatgccaa        480

ggagacagcc tcagaagcta ttatgcaagc tggtaccggc agaagccagg acaggcccct        540

gtacttgtca tctatggtaa aaacaaccgg ccctcaggga tcccagaccg attctctggc        600

tccagctcgg gaaacacagc ttccttgacc atcattgggg ctcaggcgga agacgaggct        660

gactattact gtcagtcccg ggacagcagt gataaccgtg ttctattcgg cggagggacc        720

aaggtcaccg tccta                                                         735


<210>    101
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    G03 HCDR1


<400>    101
Gly Tyr Thr Phe Thr Ser Tyr Trp
  1               5            


<210>    102
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    G03 HCDR2


<400>    102
Ile Asn Pro Gly Thr Gly Tyr Ile
  1               5            


<210>    103
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    G03 HCDR3


<400>    103
Ser Thr Ala Pro Phe Asp Tyr
  1               5        


<210>    104
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    G03 LCDR1


<400>    104
Gln Asp Ile Lys Ser Tyr
  1               5    


<210>    105
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    G03 LCDR2


<400>    105
Tyr Ala Thr
  1        


<210>    106
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    G03 LCDR3


<400>    106
Leu Gln Tyr Asp Glu Ser Pro Tyr Thr
  1               5                


<210>    107
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    G03 VH


<400>    107
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Tyr Ile Asn Pro Gly Thr Gly Tyr Ile Glu Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asp Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Ser Ser Thr Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    108
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    G03 VL


<400>    108
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr
             20                  25                  30 

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Tyr Ala Thr Arg Leu Ala Asp Gly Ile Pro Asp Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Asp Glu Ser Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105        


<210>    109
<211>    238
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    G03 scFv


<400>    109
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Ser Tyr
             20                  25                  30 

Trp Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Tyr Ile Asn Pro Gly Thr Gly Tyr Ile Glu Tyr Asn Gln Lys Phe
     50                  55                  60 

Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asp Thr Ala Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Ser Ser Thr Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125 

Gly Ala Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu
    130                 135                 140 

Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Ile
145                 150                 155                 160 

Lys Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
                165                 170                 175 

Leu Leu Ile Tyr Tyr Ala Thr Arg Leu Ala Asp Gly Ile Pro Asp Arg
            180                 185                 190 

Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg
        195                 200                 205 

Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Asp Glu
    210                 215                 220 

Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
225                 230                 235            


<210>    110
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    mucin 1


<400>    110
Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser
  1               5                  10                  15 

Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp
             20                  25                  30 

Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly
         35                  40                  45 

Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr
     50                  55                  60 

Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln
 65                  70                  75                  80 

Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile
                 85                  90                  95 

Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser
            100                 105                 110 

Gly
   


<210>    111
<211>    182
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic_CD4


<400>    111
Thr Ser Ile Thr Ala Tyr Lys Ser Glu Gly Glu Ser Ala Glu Phe Ser
  1               5                  10                  15 

Phe Pro Leu Asn Leu Gly Glu Glu Ser Leu Gln Gly Glu Leu Arg Trp
             20                  25                  30 

Lys Ala Glu Lys Ala Pro Ser Ser Gln Ser Trp Ile Thr Phe Ser Leu
         35                  40                  45 

Lys Asn Gln Lys Val Ser Val Gln Lys Ser Thr Ser Asn Pro Lys Phe
     50                  55                  60 

Gln Leu Ser Glu Thr Leu Pro Leu Thr Leu Gln Ile Pro Gln Val Ser
 65                  70                  75                  80 

Leu Gln Phe Ala Gly Ser Gly Asn Leu Thr Leu Thr Leu Asp Arg Gly
                 85                  90                  95 

Ile Leu Tyr Gln Glu Val Asn Leu Val Val Met Lys Val Thr Gln Pro
            100                 105                 110 

Asp Ser Asn Thr Leu Thr Cys Glu Val Met Gly Pro Thr Ser Pro Lys
        115                 120                 125 

Met Arg Leu Ile Leu Lys Gln Glu Asn Gln Glu Ala Arg Val Ser Arg
    130                 135                 140 

Gln Glu Lys Val Ile Gln Val Gln Ala Pro Glu Ala Gly Val Trp Gln
145                 150                 155                 160 

Cys Leu Leu Ser Glu Gly Glu Glu Val Lys Met Asp Ser Lys Ile Gln
                165                 170                 175 

Val Leu Ser Lys Gly Leu
            180        


<210>    112
<211>    135
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hinge domain


<400>    112
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg         60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg        120

gacttcgcct gtgat                                                         135


<210>    113
<211>    81
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CD28 transmembrane domain


<400>    113
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg         60

gcctttatta ttttctgggt g                                                   81


<210>    114
<211>    123
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CD28 costimulatory domain


<400>    114
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc         60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc        120

tcc                                                                      123


<210>    115
<211>    336
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CD3 zeta intracellular signaling domain


<400>    115
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc         60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc        120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat        180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc        240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc        300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                  336
