<110>    ENHANCEDBIO INC.

<120>    Lipid nanoparticles comprising mannose or uses thereof

<130>    OPP20215036KR

<150>    KR 10-2020-0183885
<151>    2020-12-24

<160>    14

<170>    KoPatentIn 3.0

<210>    1
<211>    1653
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    luciferase mRNA


<400>    1
auggaagacg ccaaaaacau aaagaaaggc ccggcgccau ucuauccgcu ggaagaugga         60

accgcuggag agcaacugca uaaggcuaug aagagauacg cccugguucc uggaacaauu        120

gcuuuuacag augcacauau cgagguggac aucacuuacg cugaguacuu cgaaaugucc        180

guucgguugg cagaagcuau gaaacgauau gggcugaaua caaaucacag aaucgucgua        240

ugcagugaaa acucucuuca auucuuuaug ccgguguugg gcgcguuauu uaucggaguu        300

gcaguugcgc ccgcgaacga cauuuauaau gaacgugaau ugcucaacag uaugggcauu        360

ucgcagccua ccgugguguu cguuuccaaa aagggguugc aaaaaauuuu gaacgugcaa        420

aaaaagcucc caaucaucca aaaaauuauu aucauggauu cuaaaacgga uuaccaggga        480

uuucagucga uguacacguu cgucacaucu caucuaccuc ccgguuuuaa ugaauacgau        540

uuugugccag aguccuucga uagggacaag acaauugcac ugaucaugaa cuccucugga        600

ucuacugguc ugccuaaagg ugucgcucug ccucauagaa cugccugcgu gagauucucg        660

caugccagag auccuauuuu uggcaaucaa aucauuccgg auacugcgau uuuaaguguu        720

guuccauucc aucacgguuu uggaauguuu acuacacucg gauauuugau auguggauuu        780

cgagucgucu uaauguauag auuugaagaa gagcuguuuc ugaggagccu ucaggauuac        840

aagauucaaa gugcgcugcu ggugccaacc cuauucuccu ucuucgccaa aagcacucug        900

auugacaaau acgauuuauc uaauuuacac gaaauugcuu cugguggcgc uccccucucu        960

aaggaagucg gggaagcggu ugccaagagg uuccaucugc cagguaucag gcaaggauau       1020

gggcucacug agacuacauc agcuauucug auuacacccg agggggauga uaaaccgggc       1080

gcggucggua aaguuguucc auuuuuugaa gcgaagguug uggaucugga uaccgggaaa       1140

acgcugggcg uuaaucaaag aggcgaacug ugugugagag guccuaugau uauguccggu       1200

uauguaaaca auccggaagc gaccaacgcc uugauugaca aggauggaug gcuacauucu       1260

ggagacauag cuuacuggga cgaagacgaa cacuucuuca ucguugaccg ccugaagucu       1320

cugauuaagu acaaaggcua ucagguggcu cccgcugaau uggaauccau cuugcuccaa       1380

caccccaaca ucuucgacgc aggugucgca ggucuucccg acgaugacgc cggugaacuu       1440

cccgccgccg uuguuguuuu ggagcacgga aagacgauga cggaaaaaga gaucguggau       1500

uacgucgcca gucaaguaac aaccgcgaaa aaguugcgcg gaggaguugu guuuguggac       1560

gaaguaccga aaggucuuac cggaaaacuc gacgcaagaa aaaucagaga gauccucaua       1620

aaggccaaga agggcggaaa gaucgccgug uaa                                    1653


<210>    2
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    FVII target siRNA_sense


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    2
ggaucaucuc aagucuuact t                                                   21


<210>    3
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    FVII target siRNA_antisense


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    3
guaagacuug agaugaucct t                                                   21


<210>    4
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    FVIII target siRNA_sense_1


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    4
cuuauaucgu ggagaauuat t                                                   21


<210>    5
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    FVIII target siRNA_antisense_1


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    5
uaauucucca cgauauaagt t                                                   21


<210>    6
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    FVIII target siRNA_sense_2


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    6
ucaaaggauu cgaugguaut t                                                   21


<210>    7
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    FVIII target siRNA_antisense_2


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    7
auaccaucga auccuuugat t                                                   21


<210>    8
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    FVIII target siRNA_sense_3


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    8
caagagcacu agugauuaut t                                                   21


<210>    9
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    FVIII target siRNA_antisense_3


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    9
auaaucacua gugcucuugt t                                                   21


<210>    10
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    FVIII target siRNA_sense_4


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    10
gggcaccacu ccugaaauat t                                                   21


<210>    11
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    FVIII target siRNA_antisense_4


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    11
uauuucagga guggugccct t                                                   21


<210>    12
<211>    1074
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Cre


<400>    12
augggcaccc ccaagaagaa gcggaaggug cggaccgacc ugaacagcaa ccugcugacc         60

gugcaccaga accugcccgc ccugcccgug gacgccacca gcgacgaggu gcggaagaac        120

cugauggaca uguuccggga ccggcaggcc uucagcgagc acaccuggaa gaugcugcug        180

agcgugugcc ggagcugggc cgccuggugc aagcugaaca accggaagug guuccccgcc        240

gagcccgagg acgugcggga cuaccugcug uaccugcagg cccggggccu ggccgugaag        300

accauccagc agcaccuggg ccagcugaac augcugcacc ggcggagcgg ccugccccgg        360

cccagcgaca gcaacgccgu gagccuggug augcggcgga uccggaagga gaacguggac        420

gccggcgagc gggccaagca ggcccuggcc uucgagcgga ccgacuucga ccaggugcgg        480

agccugaugg agaacagcga ccggugccag gacauccgga accuggccuu ccugggcauc        540

gccuacaaca cccugcugcg gaucgccgag aucgcccgga uccgggugaa ggacaucagc        600

cggaccgacg gcggccggau gcugauccac aucggccgga ccaagacccu ggugagcacc        660

gccggcgugg agaaggcccu gagccugggc gugaccaagc ugguggagcg guggaucagc        720

gugagcggcg uggccgacga ccccaacaac uaccuguucu gccgggugcg gaagaacggc        780

guggccgccc ccagcgccac cagccagcug agcacccggg cccuggaggg caucuucgag        840

gccacccacc ggcugaucua cggcgccaag gacgacagcg gccagcggua ccuggccugg        900

agcggccaca gcgcccgggu gggcgccgcc cgggacaugg cccgggccgg cgugagcauc        960

cccgagauca ugcaggccgg cggcuggacc aacgugaaca ucgugaugaa cuacauccgg       1020

aaccuggaca gcgagaccgg cgccauggug cggcugcugg aggacggcga cuga             1074


<210>    13
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    siFluc_sense


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    13
aacgcugggc guuaaucaat t                                                   21


<210>    14
<211>    21
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    siFluc_antisense


<220>
<221>    misc_feature
<222>    (20)..(21)
<223>    deoxyribonucleotides


<400>    14
uugauuaacg cccagcguut t                                                   21
