                         SEQUENCE LISTING

<110>  BIORCHESTRA Co., Ltd
 
<120>  USE OF MIRNA-485 INHIBITORS FOR INDUCING HAIR GROWTH

<130>  4366.037PC02

<150>  US 63/130,121
<151>  2020-12-23

<160>  80    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1
gucauacacg gcucuccucu cu                                                22


<210>  2
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2
uguauga                                                                  7


<210>  3
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3
guguauga                                                                 8


<210>  4
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4
cguguauga                                                                9


<210>  5
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
ccguguauga                                                              10


<210>  6
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6
gccguguaug a                                                            11


<210>  7
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7
agccguguau ga                                                           12


<210>  8
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8
gagccgugua uga                                                          13


<210>  9
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9
agagccgugu auga                                                         14


<210>  10
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10
gagagccgug uauga                                                        15


<210>  11
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11
ggagagccgu guauga                                                       16


<210>  12
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12
aggagagccg uguauga                                                      17


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13
gaggagagcc guguauga                                                     18


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14
agaggagagc cguguauga                                                    19


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15
gagaggagag ccguguauga                                                   20


<210>  16
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16
uguaugac                                                                 8


<210>  17
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17
guguaugac                                                                9


<210>  18
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18
cguguaugac                                                              10


<210>  19
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19
ccguguauga c                                                            11


<210>  20
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20
gccguguaug ac                                                           12


<210>  21
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21
agccguguau gac                                                          13


<210>  22
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22
gagccgugua ugac                                                         14


<210>  23
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23
agagccgugu augac                                                        15


<210>  24
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24
gagagccgug uaugac                                                       16


<210>  25
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25
ggagagccgu guaugac                                                      17


<210>  26
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26
aggagagccg uguaugac                                                     18


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27
gaggagagcc guguaugac                                                    19


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28
agaggagagc cguguaugac                                                   20


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29
gagaggagag ccguguauga c                                                 21


<210>  30
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30
tgtatga                                                                  7


<210>  31
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31

Met Gly Ser Ser His Leu Leu Asn Lys Gly Leu Pro Leu Gly Val Arg 
1               5                   10                  15      


Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg Pro Leu Val Ala Leu 
            20                  25                  30          


Leu Asp Gly Arg Asp Cys Thr Val Glu Met Pro Ile Leu Lys Asp Val 
        35                  40                  45              


Ala Thr Val Ala Phe Cys Asp Ala Gln Ser Thr Gln Glu Ile His Glu 
    50                  55                  60                  


Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met Tyr His Thr Ile Thr 
65                  70                  75                  80  


Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys Ala Leu Arg Ile Ile Val 
                85                  90                  95      


Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile Lys Ser Ala Gly Asp 
            100                 105                 110         


Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala Ser Val Glu Glu Thr 
        115                 120                 125             


Ala Asp Ser Thr Leu Cys His Ile Leu Asn Leu Tyr Arg Arg Ala Thr 
    130                 135                 140                 


Trp Leu His Gln Ala Leu Arg Glu Gly Thr Arg Val Gln Ser Val Glu 
145                 150                 155                 160 


Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg Ile Arg Gly Glu Thr 
                165                 170                 175     


Leu Gly Ile Ile Gly Leu Gly Arg Val Gly Gln Ala Val Ala Leu Arg 
            180                 185                 190         


Ala Lys Ala Phe Gly Phe Asn Val Leu Phe Tyr Asp Pro Tyr Leu Ser 
        195                 200                 205             


Asp Gly Val Glu Arg Ala Leu Gly Leu Gln Arg Val Ser Thr Leu Gln 
    210                 215                 220                 


Asp Leu Leu Phe His Ser Asp Cys Val Thr Leu His Cys Gly Leu Asn 
225                 230                 235                 240 


Glu His Asn His His Leu Ile Asn Asp Phe Thr Val Lys Gln Met Arg 
                245                 250                 255     


Gln Gly Ala Phe Leu Val Asn Thr Ala Arg Gly Gly Leu Val Asp Glu 
            260                 265                 270         


Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg Ile Arg Gly Ala Ala 
        275                 280                 285             


Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe Ser Gln Gly Pro Leu 
    290                 295                 300                 


Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro His Ala Ala Trp Tyr Ser 
305                 310                 315                 320 


Glu Gln Ala Ser Ile Glu Met Arg Glu Glu Ala Ala Arg Glu Ile Arg 
                325                 330                 335     


Arg Ala Ile Thr Gly Arg Ile Pro Asp Ser Leu Lys Asn Cys Val Asn 
            340                 345                 350         


Lys Asp His Leu Thr Ala Ala Thr His Trp Ala Ser Met Asp Pro Ala 
        355                 360                 365             


Val Val His Pro Glu Leu Asn Gly Ala Ala Tyr Arg Tyr Pro Pro Gly 
    370                 375                 380                 


Val Val Gly Val Ala Pro Thr Gly Ile Pro Ala Ala Val Glu Gly Ile 
385                 390                 395                 400 


Val Pro Ser Ala Met Ser Leu Ser His Gly Leu Pro Pro Val Ala His 
                405                 410                 415     


Pro Pro His Ala Pro Ser Pro Gly Gln Thr Val Lys Pro Glu Ala Asp 
            420                 425                 430         


Arg Asp His Ala Ser Asp Gln Leu 
        435                 440 


<210>  32
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Met Ser Gly Val Arg Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg 
1               5                   10                  15      


Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Thr Val Glu Met Pro 
            20                  25                  30          


Ile Leu Lys Asp Val Ala Thr Val Ala Phe Cys Asp Ala Gln Ser Thr 
        35                  40                  45              


Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met 
    50                  55                  60                  


Tyr His Thr Ile Thr Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys Ala 
65                  70                  75                  80  


Leu Arg Ile Ile Val Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile 
                85                  90                  95      


Lys Ser Ala Gly Asp Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala 
            100                 105                 110         


Ser Val Glu Glu Thr Ala Asp Ser Thr Leu Cys His Ile Leu Asn Leu 
        115                 120                 125             


Tyr Arg Arg Ala Thr Trp Leu His Gln Ala Leu Arg Glu Gly Thr Arg 
    130                 135                 140                 


Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg 
145                 150                 155                 160 


Ile Arg Gly Glu Thr Leu Gly Ile Ile Gly Leu Gly Arg Val Gly Gln 
                165                 170                 175     


Ala Val Ala Leu Arg Ala Lys Ala Phe Gly Phe Asn Val Leu Phe Tyr 
            180                 185                 190         


Asp Pro Tyr Leu Ser Asp Gly Val Glu Arg Ala Leu Gly Leu Gln Arg 
        195                 200                 205             


Val Ser Thr Leu Gln Asp Leu Leu Phe His Ser Asp Cys Val Thr Leu 
    210                 215                 220                 


His Cys Gly Leu Asn Glu His Asn His His Leu Ile Asn Asp Phe Thr 
225                 230                 235                 240 


Val Lys Gln Met Arg Gln Gly Ala Phe Leu Val Asn Thr Ala Arg Gly 
                245                 250                 255     


Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg 
            260                 265                 270         


Ile Arg Gly Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe 
        275                 280                 285             


Ser Gln Gly Pro Leu Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro His 
    290                 295                 300                 


Ala Ala Trp Tyr Ser Glu Gln Ala Ser Ile Glu Met Arg Glu Glu Ala 
305                 310                 315                 320 


Ala Arg Glu Ile Arg Arg Ala Ile Thr Gly Arg Ile Pro Asp Ser Leu 
                325                 330                 335     


Lys Asn Cys Val Asn Lys Asp His Leu Thr Ala Ala Thr His Trp Ala 
            340                 345                 350         


Ser Met Asp Pro Ala Val Val His Pro Glu Leu Asn Gly Ala Ala Tyr 
        355                 360                 365             


Arg Tyr Pro Pro Gly Val Val Gly Val Ala Pro Thr Gly Ile Pro Ala 
    370                 375                 380                 


Ala Val Glu Gly Ile Val Pro Ser Ala Met Ser Leu Ser His Gly Leu 
385                 390                 395                 400 


Pro Pro Val Ala His Pro Pro His Ala Pro Ser Pro Gly Gln Thr Val 
                405                 410                 415     


Lys Pro Glu Ala Asp Arg Asp His Ala Ser Asp Gln Leu 
            420                 425                 


<210>  33
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33
agaggcuggc cgugaugaau uc                                                22


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34
agucauacac ggcucuccuc uc                                                22


<210>  35
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35
gagccgtgta tga                                                          13


<210>  36
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  37
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Glu Thr Cys Val His Phe Thr Ser Ser Phe Ser Val Cys Lys Ser 
        275                 280                 285             


<210>  38
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Ser Ile Tyr Ala Val Phe 
225                 230                 235                 240 


Glu Ser Asp Val Asn Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu 
                245                 250                 255     


Pro Ser Lys Ala Phe Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys 
            260                 265                 270         


Phe Cys Thr Glu Lys Ile Ile Ser Lys Asn Cys Thr Ser Tyr Gly Val 
        275                 280                 285             


Leu Asp Ile Ser Lys Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu 
    290                 295                 300                 


Pro His Phe Leu Tyr Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly 
305                 310                 315                 320 


Leu Asn Pro Asn Glu Glu Glu His Arg Thr Tyr Leu Asp Ile Glu Pro 
                325                 330                 335     


Ile Thr Gly Phe Thr Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu 
            340                 345                 350         


Leu Val Lys Pro Ser Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg 
        355                 360                 365             


Asn Tyr Ile Val Pro Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly 
    370                 375                 380                 


Asp Glu Lys Ala Asn Met Phe Arg Ser Gln Val Thr Gly Lys Ile Asn 
385                 390                 395                 400 


Leu Leu Gly Leu Ile Glu Met Ile Leu Leu Ser Val Gly Val Val Met 
                405                 410                 415     


Phe Val Ala Phe Met Ile Ser Tyr Cys Ala Cys Arg Ser Lys Thr Ile 
            420                 425                 430         


Lys 
    


<210>  39
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Tyr 
    130                 135                 140                 


Asn Asn Thr Ala Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn 
145                 150                 155                 160 


Ile Ser Lys Val Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu 
                165                 170                 175     


Ser Tyr Trp Glu Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala 
            180                 185                 190         


Ser Phe Pro Pro Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser 
        195                 200                 205             


Ser Asp Ile Cys Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn 
    210                 215                 220                 


Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe 
225                 230                 235                 240 


Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys 
                245                 250                 255     


Ile Ile Ser Lys Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys 
            260                 265                 270         


Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr 
        275                 280                 285             


Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu 
    290                 295                 300                 


Glu Glu His Arg Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr 
305                 310                 315                 320 


Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser 
                325                 330                 335     


Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro 
            340                 345                 350         


Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn 
        355                 360                 365             


Met Phe Arg Ser Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile 
    370                 375                 380                 


Glu Met Ile Leu Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met 
385                 390                 395                 400 


Ile Ser Tyr Cys Ala Cys Arg Ser Lys Thr Ile Lys 
                405                 410         


<210>  40
<211>  798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly 
            260                 265                 270         


Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu 
        275                 280                 285             


Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys Ala 
    290                 295                 300                 


Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser Cys 
305                 310                 315                 320 


Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu Ser 
                325                 330                 335     


Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln Ser 
            340                 345                 350         


Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly His 
        355                 360                 365             


Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp His 
    370                 375                 380                 


Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn Ile 
385                 390                 395                 400 


Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val Ser 
                405                 410                 415     


Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln Cys 
            420                 425                 430         


Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys Ser 
        435                 440                 445             


Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn Lys 
    450                 455                 460                 


His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp Lys 
465                 470                 475                 480 


Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser Lys 
                485                 490                 495     


Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe Asp 
            500                 505                 510         


Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly Thr 
        515                 520                 525             


Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe Asn 
    530                 535                 540                 


Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser Gln 
545                 550                 555                 560 


Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His Arg 
                565                 570                 575     


Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro Gly 
            580                 585                 590         


Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His Tyr 
        595                 600                 605             


Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg Ser 
    610                 615                 620                 


Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu Tyr 
625                 630                 635                 640 


Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu Lys 
                645                 650                 655     


Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys Ala 
            660                 665                 670         


Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp Thr 
        675                 680                 685             


Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile Glu 
    690                 695                 700                 


Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe Ile 
705                 710                 715                 720 


Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly Tyr 
                725                 730                 735     


Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys Gly 
            740                 745                 750         


Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn Ser 
        755                 760                 765             


Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu Asp 
    770                 775                 780                 


Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg 
785                 790                 795             


<210>  41
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Leu Phe Leu 
            260                 265                 270     


<210>  42
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42

Met Asp Glu Thr Ser Pro Arg Leu Glu Glu Asp Trp Lys Lys Val Leu 
1               5                   10                  15      


Gln Arg Glu Ala Gly Trp Gln Cys Ala Ala Leu Val Gly Glu Asp Gln 
            20                  25                  30          


Pro Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val 
        35                  40                  45              


Asn Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser 
    50                  55                  60                  


Asp Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn 
65                  70                  75                  80  


Ile Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val 
                85                  90                  95      


Leu Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro 
            100                 105                 110         


Ser Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala 
        115                 120                 125             


Ser Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu 
    130                 135                 140                 


Glu Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln 
145                 150                 155                 160 


Leu Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn 
                165                 170                 175     


His Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn 
            180                 185                 190         


Ser Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln 
        195                 200                 205             


Arg Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp 
    210                 215                 220                 


Pro Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys 
225                 230                 235                 240 


Cys Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu 
                245                 250                 255     


Gln Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro 
            260                 265                 270         


Asn Asp Pro Lys Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr 
        275                 280                 285             


Leu Ser Val Glu Leu Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr 
    290                 295                 300                 


Pro Pro His Lys Ala Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys 
305                 310                 315                 320 


Leu Lys Ser Ser Cys Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro 
                325                 330                 335     


Arg Tyr Ser Glu Ser Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys 
            340                 345                 350         


Gly Pro Glu Gln Ser Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val 
        355                 360                 365             


Leu Thr Gly Gly His Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg 
    370                 375                 380                 


Leu Phe Gly Asp His Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu 
385                 390                 395                 400 


Ile Leu Ile Asn Ile Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu 
                405                 410                 415     


Asn Lys Asp Val Ser Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr 
            420                 425                 430         


Asp Ser Asp Gln Cys Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln 
        435                 440                 445             


Val Ser Pro Cys Ser Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg 
    450                 455                 460                 


Ala Glu Leu Asn Lys His Phe Gly His Pro Ser Gln Ala Val Phe Asp 
465                 470                 475                 480 


Asp Glu Ala Asp Lys Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn 
                485                 490                 495     


Glu Gln Phe Ser Lys Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met 
            500                 505                 510         


Asp Gly Leu Phe Asp Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr 
        515                 520                 525             


Pro Trp Asp Gly Thr Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser 
    530                 535                 540                 


Cys Ser Ser Phe Asn Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys 
545                 550                 555                 560 


Ser Leu Phe Ser Gln Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser 
                565                 570                 575     


Phe Ser Arg His Arg Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg 
            580                 585                 590         


Ser Arg Ser Pro Gly Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr 
        595                 600                 605             


Glu Ser Ser His Tyr Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr 
    610                 615                 620                 


Val Arg Ser Arg Ser Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp 
625                 630                 635                 640 


Ser Tyr Glu Glu Tyr Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg 
                645                 650                 655     


Arg Glu Tyr Glu Lys Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg 
            660                 665                 670         


Gln Arg Gln Lys Ala Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys 
        675                 680                 685             


Ile Arg Pro Asp Thr Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val 
    690                 695                 700                 


Phe Gly Glu Ile Glu Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp 
705                 710                 715                 720 


Ser Tyr Gly Phe Ile Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala 
                725                 730                 735     


Leu Glu Asn Gly Tyr Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu 
            740                 745                 750         


Leu Tyr Phe Cys Gly Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp 
        755                 760                 765             


Leu Asp Ser Asn Ser Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys 
    770                 775                 780                 


Tyr Asp Ser Leu Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser 
785                 790                 795                 800 


Leu Arg Arg 
            


<210>  43
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43

Met Asp Glu Gly Tyr Phe Cys Ala Ala Leu Val Gly Glu Asp Gln Pro 
1               5                   10                  15      


Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn 
            20                  25                  30          


Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp 
        35                  40                  45              


Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile 
    50                  55                  60                  


Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu 
65                  70                  75                  80  


Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser 
                85                  90                  95      


Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser 
            100                 105                 110         


Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu 
        115                 120                 125             


Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu 
    130                 135                 140                 


Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His 
145                 150                 155                 160 


Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser 
                165                 170                 175     


Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg 
            180                 185                 190         


Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro 
        195                 200                 205             


Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys 
    210                 215                 220                 


Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln 
225                 230                 235                 240 


Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn 
                245                 250                 255     


Asp Pro Lys Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu 
            260                 265                 270         


Ser Val Glu Leu Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro 
        275                 280                 285             


Pro His Lys Ala Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu 
    290                 295                 300                 


Lys Ser Ser Cys Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg 
305                 310                 315                 320 


Tyr Ser Glu Ser Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly 
                325                 330                 335     


Pro Glu Gln Ser Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu 
            340                 345                 350         


Thr Gly Gly His Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu 
        355                 360                 365             


Phe Gly Asp His Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile 
    370                 375                 380                 


Leu Ile Asn Ile Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn 
385                 390                 395                 400 


Lys Asp Val Ser Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp 
                405                 410                 415     


Ser Asp Gln Cys Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val 
            420                 425                 430         


Ser Pro Cys Ser Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala 
        435                 440                 445             


Glu Leu Asn Lys His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp 
    450                 455                 460                 


Glu Ala Asp Lys Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu 
465                 470                 475                 480 


Gln Phe Ser Lys Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp 
                485                 490                 495     


Gly Leu Phe Asp Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro 
            500                 505                 510         


Trp Asp Gly Thr Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys 
        515                 520                 525             


Ser Ser Phe Asn Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser 
    530                 535                 540                 


Leu Phe Ser Gln Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe 
545                 550                 555                 560 


Ser Arg His Arg Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser 
                565                 570                 575     


Arg Ser Pro Gly Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu 
            580                 585                 590         


Ser Ser His Tyr Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val 
        595                 600                 605             


Arg Ser Arg Ser Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser 
    610                 615                 620                 


Tyr Glu Glu Tyr Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg 
625                 630                 635                 640 


Glu Tyr Glu Lys Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln 
                645                 650                 655     


Arg Gln Lys Ala Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile 
            660                 665                 670         


Arg Pro Asp Thr Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe 
        675                 680                 685             


Gly Glu Ile Glu Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser 
    690                 695                 700                 


Tyr Gly Phe Ile Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu 
705                 710                 715                 720 


Glu Asn Gly Tyr Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu 
                725                 730                 735     


Tyr Phe Cys Gly Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu 
            740                 745                 750         


Asp Ser Asn Ser Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr 
        755                 760                 765             


Asp Ser Leu Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu 
    770                 775                 780                 


Arg Arg 
785     


<210>  44
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Met Asp Glu Gly Tyr Phe Cys Ala Ala Leu Val Gly Glu Asp Gln Pro 
1               5                   10                  15      


Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn 
            20                  25                  30          


Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp 
        35                  40                  45              


Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile 
    50                  55                  60                  


Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu 
65                  70                  75                  80  


Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser 
                85                  90                  95      


Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser 
            100                 105                 110         


Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu 
        115                 120                 125             


Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu 
    130                 135                 140                 


Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His 
145                 150                 155                 160 


Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser 
                165                 170                 175     


Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg 
            180                 185                 190         


Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro 
        195                 200                 205             


Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys 
    210                 215                 220                 


Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln 
225                 230                 235                 240 


Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn 
                245                 250                 255     


Asp Pro Lys Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu 
            260                 265                 270         


Ser Val Glu Leu Ser Gly Thr Ala Gly Val Lys Thr Asn Leu Ile Ser 
        275                 280                 285             


Lys 
    


<210>  45
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45

Met Asp Glu Thr Ser Pro Arg Leu Glu Glu Asp Trp Lys Lys Val Leu 
1               5                   10                  15      


Gln Arg Glu Ala Gly Trp Gln Cys Ala Ala Leu Val Gly Glu Asp Gln 
            20                  25                  30          


Pro Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val 
        35                  40                  45              


Asn Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser 
    50                  55                  60                  


Asp Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn 
65                  70                  75                  80  


Ile Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val 
                85                  90                  95      


Leu Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro 
            100                 105                 110         


Ser Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala 
        115                 120                 125             


Ser Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu 
    130                 135                 140                 


Glu Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln 
145                 150                 155                 160 


Leu Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn 
                165                 170                 175     


His Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn 
            180                 185                 190         


Ser Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln 
        195                 200                 205             


Arg Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp 
    210                 215                 220                 


Pro Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys 
225                 230                 235                 240 


Cys Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu 
                245                 250                 255     


Gln Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro 
            260                 265                 270         


Asn Leu Phe Leu 
        275     


<210>  46
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46

Met Asp Glu Gly Tyr Phe Cys Ala Ala Leu Val Gly Glu Asp Gln Pro 
1               5                   10                  15      


Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn 
            20                  25                  30          


Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp 
        35                  40                  45              


Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile 
    50                  55                  60                  


Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu 
65                  70                  75                  80  


Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser 
                85                  90                  95      


Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser 
            100                 105                 110         


Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu 
        115                 120                 125             


Pro Ser Leu Val Arg Thr Leu Pro Thr Val 
    130                 135             


<210>  47
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly 
            260                 265                 270         


Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu 
        275                 280                 285             


Ser Gly Thr Ala Gly Val Lys Thr Asn Leu Ile Ser Lys 
    290                 295                 300     


<210>  48
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48

Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu 
1               5                   10                  15      


Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn 
            20                  25                  30          


Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg 
        35                  40                  45              


Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn 
    50                  55                  60                  


Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys 
65                  70                  75                  80  


Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr 
                85                  90                  95      


Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys 
            100                 105                 110         


Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro 
        115                 120                 125             


Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys 
    130                 135                 140                 


Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu 
145                 150                 155                 160 


Leu Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys 
                165                 170                 175     


Ala Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser 
            180                 185                 190         


Cys Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu 
        195                 200                 205             


Ser Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln 
    210                 215                 220                 


Ser Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly 
225                 230                 235                 240 


His Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp 
                245                 250                 255     


His Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn 
            260                 265                 270         


Ile Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val 
        275                 280                 285             


Ser Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln 
    290                 295                 300                 


Cys Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys 
305                 310                 315                 320 


Ser Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn 
                325                 330                 335     


Lys His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp 
            340                 345                 350         


Lys Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser 
        355                 360                 365             


Lys Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe 
    370                 375                 380                 


Asp Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly 
385                 390                 395                 400 


Thr Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe 
                405                 410                 415     


Asn Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser 
            420                 425                 430         


Gln Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His 
        435                 440                 445             


Arg Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro 
    450                 455                 460                 


Gly Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His 
465                 470                 475                 480 


Tyr Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg 
                485                 490                 495     


Ser Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu 
            500                 505                 510         


Tyr Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu 
        515                 520                 525             


Lys Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys 
    530                 535                 540                 


Ala Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp 
545                 550                 555                 560 


Thr Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile 
                565                 570                 575     


Glu Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe 
            580                 585                 590         


Ile Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly 
        595                 600                 605             


Tyr Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys 
    610                 615                 620                 


Gly Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn 
625                 630                 635                 640 


Ser Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu 
                645                 650                 655     


Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg 
            660                 665                 670     


<210>  49
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49
ucauaca                                                                  7


<210>  50
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50
gaggcug                                                                  7


<210>  51
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51
gtgtatga                                                                 8


<210>  52
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52
cgtgtatga                                                                9


<210>  53
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53
ccgtgtatga                                                              10


<210>  54
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54
gccgtgtatg a                                                            11


<210>  55
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55
agccgtgtat ga                                                           12


<210>  56
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56
agagccgtgt atga                                                         14


<210>  57
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57
gagagccgtg tatga                                                        15


<210>  58
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58
ggagagccgt gtatga                                                       16


<210>  59
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59
aggagagccg tgtatga                                                      17


<210>  60
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60
gaggagagcc gtgtatga                                                     18


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  61
gagaggagag ccgtgtatga                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62
gagaggagag ccgtgtatga                                                   20


<210>  63
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  63
tgtatgac                                                                 8


<210>  64
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  64
gtgtatgac                                                                9


<210>  65
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  65
cgtgtatgac                                                              10


<210>  66
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  66
ccgtgtatga c                                                            11


<210>  67
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  67
gccgtgtatg ac                                                           12


<210>  68
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  68
agccgtgtat gac                                                          13


<210>  69
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  69
gagccgtgta tgac                                                         14


<210>  70
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  70
agagccgtgt atgac                                                        15


<210>  71
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  71
gagagccgtg tatgac                                                       16


<210>  72
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  72
ggagagccgt gtatgac                                                      17


<210>  73
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  73
aggagagccg tgtatgac                                                     18


<210>  74
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  74
gaggagagcc gtgtatgac                                                    19


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  75
agaggagagc cgtgtatgac                                                   20


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  76
gagaggagag ccgtgtatga c                                                 21


<210>  77
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  77
agaggagagc cgtgtatgac                                                   20


<210>  78
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  78

Met Ser Gly Pro Thr Trp Leu Pro Pro Lys Gln Pro Glu Pro Ala Arg 
1               5                   10                  15      


Ala Pro Gln Gly Arg Ala Ile Pro Arg Gly Thr Pro Gly Pro Pro Pro 
            20                  25                  30          


Ala His Gly Ala Ala Leu Gln Pro His Pro Arg Val Asn Phe Cys Pro 
        35                  40                  45              


Leu Pro Ser Glu Gln Cys Tyr Gln Ala Pro Gly Gly Pro Glu Asp Arg 
    50                  55                  60                  


Gly Pro Ala Trp Val Gly Ser His Gly Val Leu Gln His Thr Gln Gly 
65                  70                  75                  80  


Leu Pro Ala Asp Arg Gly Gly Leu Arg Pro Gly Ser Leu Asp Ala Glu 
                85                  90                  95      


Ile Asp Leu Leu Ser Ser Thr Leu Ala Glu Leu Asn Gly Gly Arg Gly 
            100                 105                 110         


His Ala Ser Arg Arg Pro Asp Arg Gln Ala Tyr Glu Pro Pro Pro Pro 
        115                 120                 125             


Pro Ala Tyr Arg Thr Gly Ser Leu Lys Pro Asn Pro Ala Ser Pro Leu 
    130                 135                 140                 


Pro Ala Ser Pro Tyr Gly Gly Pro Thr Pro Ala Ser Tyr Thr Thr Ala 
145                 150                 155                 160 


Ser Thr Pro Ala Gly Pro Ala Phe Pro Val Gln Val Lys Val Ala Gln 
                165                 170                 175     


Pro Val Arg Gly Cys Gly Pro Pro Arg Arg Gly Ala Ser Gln Ala Ser 
            180                 185                 190         


Gly Pro Leu Pro Gly Pro His Phe Pro Leu Pro Gly Arg Gly Glu Val 
        195                 200                 205             


Trp Gly Pro Gly Tyr Arg Ser Gln Arg Glu Pro Gly Pro Gly Ala Lys 
    210                 215                 220                 


Glu Glu Ala Ala Gly Val Ser Gly Pro Ala Gly Arg Gly Arg Gly Gly 
225                 230                 235                 240 


Glu His Gly Pro Gln Val Pro Leu Ser Gln Pro Pro Glu Asp Glu Leu 
                245                 250                 255     


Asp Arg Leu Thr Lys Lys Leu Val His Asp Met Asn His Pro Pro Ser 
            260                 265                 270         


Gly Glu Tyr Phe Gly Gln Cys Gly Gly Cys Gly Glu Asp Val Val Gly 
        275                 280                 285             


Asp Gly Ala Gly Val Val Ala Leu Asp Arg Val Phe His Val Gly Cys 
    290                 295                 300                 


Phe Val Cys Ser Thr Cys Arg Ala Gln Leu Arg Gly Gln His Phe Tyr 
305                 310                 315                 320 


Ala Val Glu Arg Arg Ala Tyr Cys Glu Gly Cys Tyr Val Ala Thr Leu 
                325                 330                 335     


Glu Lys Cys Ala Thr Cys Ser Gln Pro Ile Leu Asp Arg Ile Leu Arg 
            340                 345                 350         


Ala Met Gly Lys Ala Tyr His Pro Gly Cys Phe Thr Cys Val Val Cys 
        355                 360                 365             


His Arg Gly Leu Asp Gly Ile Pro Phe Thr Val Asp Ala Thr Ser Gln 
    370                 375                 380                 


Ile His Cys Ile Glu Asp Phe His Arg Lys Phe Ala Pro Arg Cys Ser 
385                 390                 395                 400 


Val Cys Gly Gly Ala Ile Met Pro Glu Pro Gly Gln Glu Glu Thr Val 
                405                 410                 415     


Arg Ile Val Ala Leu Asp Arg Ser Phe His Ile Gly Cys Tyr Lys Cys 
            420                 425                 430         


Glu Glu Cys Gly Leu Leu Leu Ser Ser Glu Gly Glu Cys Gln Gly Cys 
        435                 440                 445             


Tyr Pro Leu Asp Gly His Ile Leu Cys Lys Ala Cys Ser Ala Trp Arg 
    450                 455                 460                 


Ile Gln Glu Leu Ser Ala Thr Val Thr Thr Asp Cys 
465                 470                 475     


<210>  79
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  79

Ser Gly Pro Thr Trp Leu Pro Pro Lys Gln Pro Glu Pro Ala Arg Ala 
1               5                   10                  15      


Pro Gln Gly Arg Ala Ile Pro Arg Gly Thr Pro Gly Pro Pro Pro Ala 
            20                  25                  30          


His Gly Ala Val Leu Pro Gly Pro Arg Gly Thr Gly Gly Ser Gly Ala 
        35                  40                  45              


Gly Val Gly Gly Val Pro Trp Ser Thr Pro Ala His Ala Gly Ala Pro 
    50                  55                  60                  


Cys Arg Gln Gly Gly Pro Ser Pro Trp Lys Pro Gly Arg Arg Asp Arg 
65                  70                  75                  80  


Leu Ala Glu Gln His Ala Gly Arg Ala Glu Trp Gly Ser Gly Ser Cys 
                85                  90                  95      


Val Thr Ala Thr Arg Pro Thr Gly Ile 
            100                 105 


<210>  80
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  80

Met Ser Gly Pro Thr Trp Leu Pro Pro Lys Gln Pro Glu Pro Ala Arg 
1               5                   10                  15      


Ala Pro Gln Gly Arg Ala Ile Pro Arg Gly Thr Pro Gly Pro Pro Pro 
            20                  25                  30          


Ala His Gly Ala Gly Ala Pro Cys Arg Gln Gly Gly Pro Ser Pro Trp 
        35                  40                  45              


Lys Pro Gly Arg Arg Asp Arg Leu Ala Glu Gln His Ala Gly Arg Ala 
    50                  55                  60                  


Glu Trp Gly Ser Gly Ser Cys Val Thr Ala Thr Arg Pro Thr Gly Ile 
65                  70                  75                  80  



