                         SEQUENCE LISTING

<110>  Quell Therapeutics Limited
 
<120>  Inducible signalling protein

<130>  27.130.152737/02

<150>  GB 2020541.5
<151>  2020-12-23

<150>  GB 2117281.2
<151>  2021-11-30

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  2
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  3
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB with T to L substitution at 2098

<400>  3

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  4
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB segment of mTOR with T to H substitution at 2098 and to W at 
       F at residue 2101

<400>  4

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu His Gln Ala Phe Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  5
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB segment of mTOR with K to P substitution at residue 2095

<400>  5

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Pro Asp 
65                  70                  75                  80  


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  6
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB sequence from SEQ ID NO. 1 protein of WO2016/135470

<400>  6

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Tyr 
            100 


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP sequence from SEQ ID NO. 4 protein of WO2016/135470

<400>  7

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  8
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Codon-wobbled FKBP sequence from SEQ ID NO. 4 protein of 
       WO2016/135470 (FKBPw)

<400>  8

Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser 
            100                 105                 110     


<210>  9
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid numbers 266 to 551 of IL-2 receptor beta chain

<400>  9

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  10
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7RA

<400>  10

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
65                  70                  75                  80  


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                85                  90                  95      


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            100                 105                 110         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        115                 120                 125             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    130                 135                 140                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
145                 150                 155                 160 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                165                 170                 175     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            180                 185                 190         


Gln Asn Gln 
        195 


<210>  11
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL9R

<400>  11

Lys Leu Ser Pro Arg Val Lys Arg Ile Phe Tyr Gln Asn Val Pro Ser 
1               5                   10                  15      


Pro Ala Met Phe Phe Gln Pro Leu Tyr Ser Val His Asn Gly Asn Phe 
            20                  25                  30          


Gln Thr Trp Met Gly Ala His Gly Ala Gly Val Leu Leu Ser Gln Asp 
        35                  40                  45              


Cys Ala Gly Thr Pro Gln Gly Ala Leu Glu Pro Cys Val Gln Glu Ala 
    50                  55                  60                  


Thr Ala Leu Leu Thr Cys Gly Pro Ala Arg Pro Trp Lys Ser Val Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Gln Glu Gly Pro Gly Thr Arg Leu Pro Gly Asn Leu 
                85                  90                  95      


Ser Ser Glu Asp Val Leu Pro Ala Gly Cys Thr Glu Trp Arg Val Gln 
            100                 105                 110         


Thr Leu Ala Tyr Leu Pro Gln Glu Asp Trp Ala Pro Thr Ser Leu Thr 
        115                 120                 125             


Arg Pro Ala Pro Pro Asp Ser Glu Gly Ser Arg Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Asn Asn Asn Asn Tyr Cys Ala Leu Gly Cys Tyr Gly Gly 
145                 150                 155                 160 


Trp His Leu Ser Ala Leu Pro Gly Asn Thr Gln Ser Ser Gly Pro Ile 
                165                 170                 175     


Pro Ala Leu Ala Cys Gly Leu Ser Cys Asp His Gln Gly Leu Glu Thr 
            180                 185                 190         


Gln Gln Gly Val Ala Trp Val Leu Ala Gly His Cys Gln Arg Pro Gly 
        195                 200                 205             


Leu His Glu Asp Leu Gln Gly Met Leu Leu Pro Ser Val Leu Ser Lys 
    210                 215                 220                 


Ala Arg Ser Trp Thr Phe 
225                 230 


<210>  12
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL4RA

<400>  12

Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
1               5                   10                  15      


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
            20                  25                  30          


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
        35                  40                  45              


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
    50                  55                  60                  


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
65                  70                  75                  80  


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
                85                  90                  95      


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
            100                 105                 110         


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
        115                 120                 125             


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
    130                 135                 140                 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
145                 150                 155                 160 


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
                165                 170                 175     


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
            180                 185                 190         


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
        195                 200                 205             


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
    210                 215                 220                 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
225                 230                 235                 240 


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
                245                 250                 255     


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
            260                 265                 270         


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
        275                 280                 285             


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
    290                 295                 300                 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
305                 310                 315                 320 


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
                325                 330                 335     


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
            340                 345                 350         


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
        355                 360                 365             


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
    370                 375                 380                 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
385                 390                 395                 400 


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
                405                 410                 415     


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
            420                 425                 430         


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
        435                 440                 445             


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
    450                 455                 460                 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
465                 470                 475                 480 


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
                485                 490                 495     


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
            500                 505                 510         


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
        515                 520                 525             


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
    530                 535                 540                 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
545                 550                 555                 560 


Val Gly Pro Thr Tyr Met Arg Val Ser 
                565                 


<210>  13
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL3RB

<400>  13

Arg Phe Cys Gly Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu 
1               5                   10                  15      


Lys Ile Pro Asn Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala 
            20                  25                  30          


Glu Leu Trp Pro Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro 
        35                  40                  45              


Pro His Gln Gly Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val 
    50                  55                  60                  


Phe Pro Val Gly Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu 
65                  70                  75                  80  


Asp Pro Lys His Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro 
                85                  90                  95      


Ala Ala Ser Asp Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly 
            100                 105                 110         


Pro Pro Ala Ala Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp 
        115                 120                 125             


Phe Asn Gly Pro Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp 
    130                 135                 140                 


Ile Leu Gly Gln Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser 
145                 150                 155                 160 


Pro Pro Pro Gly Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln 
                165                 170                 175     


Val Gln Leu Val Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val 
            180                 185                 190         


Glu Val Glu Arg Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu 
        195                 200                 205             


Glu Ser Gly Gly Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly 
    210                 215                 220                 


Gly Gln Asp Gln Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly 
225                 230                 235                 240 


Asp Thr Glu Asp Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp 
                245                 250                 255     


Leu Val Phe Thr Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro 
            260                 265                 270         


Ser Leu Gly Leu Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu 
        275                 280                 285             


Ala Ser Gly Pro Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu 
    290                 295                 300                 


Gly Tyr Val Glu Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro 
305                 310                 315                 320 


Arg Asn Asn Pro Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro 
                325                 330                 335     


Gly Glu Arg Pro Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly 
            340                 345                 350         


Leu Leu Val Leu Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu 
        355                 360                 365             


Gly Pro Gly Pro Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro 
    370                 375                 380                 


Gly Pro Glu Ile Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro 
385                 390                 395                 400 


Pro Gly Gln Ala Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala 
                405                 410                 415     


Leu Lys Gln Gln Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys 
            420                 425                 430         


Pro Gly Glu Val Cys 
        435         


<210>  14
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17RB

<400>  14

Arg His Glu Arg Ile Lys Lys Thr Ser Phe Ser Thr Thr Thr Leu Leu 
1               5                   10                  15      


Pro Pro Ile Lys Val Leu Val Val Tyr Pro Ser Glu Ile Cys Phe His 
            20                  25                  30          


His Thr Ile Cys Tyr Phe Thr Glu Phe Leu Gln Asn His Cys Arg Ser 
        35                  40                  45              


Glu Val Ile Leu Glu Lys Trp Gln Lys Lys Lys Ile Ala Glu Met Gly 
    50                  55                  60                  


Pro Val Gln Trp Leu Ala Thr Gln Lys Lys Ala Ala Asp Lys Val Val 
65                  70                  75                  80  


Phe Leu Leu Ser Asn Asp Val Asn Ser Val Cys Asp Gly Thr Cys Gly 
                85                  90                  95      


Lys Ser Glu Gly Ser Pro Ser Glu Asn Ser Gln Asp Leu Phe Pro Leu 
            100                 105                 110         


Ala Phe Asn Leu Phe Cys Ser Asp Leu Arg Ser Gln Ile His Leu His 
        115                 120                 125             


Lys Tyr Val Val Val Tyr Phe Arg Glu Ile Asp Thr Lys Asp Asp Tyr 
    130                 135                 140                 


Asn Ala Leu Ser Val Cys Pro Lys Tyr His Leu Met Lys Asp Ala Thr 
145                 150                 155                 160 


Ala Phe Cys Ala Glu Leu Leu His Val Lys Gln Gln Val Ser Ala Gly 
                165                 170                 175     


Lys Arg Ser Gln Ala Cys His Asp Gly Cys Cys Ser Leu 
            180                 185                 


<210>  15
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7RA 2Y truncated

<400>  15

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
65                  70                  75                  80  


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
                85                  90      


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be Phe or Leu

<400>  16

Tyr Xaa Xaa Xaa 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  17

Tyr Cys Thr Phe 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  18

Tyr Phe Phe Phe 
1               


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  19

Tyr Leu Ser Leu 
1               


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  20

Tyr Leu Ser Leu Gln 
1               5   


<210>  21
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1 binding motif

<400>  21

Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln 
1               5                   10                  15      


Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro 
            20                  25                  30          


Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser 
        35                  40                  45              


Pro Leu Glu Val Leu Glu Arg Asp Lys 
    50                  55          


<210>  22
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1 binding motif

<400>  22

Asn Pro Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Asp Phe Ser 
1               5                   10                  15      


Gly His Thr His Pro Val Ala Thr Phe Gln Pro Ser Arg Pro Glu Ser 
            20                  25                  30          


Val Asn Asp Leu Phe Leu Cys Pro Gln Lys Glu Leu Thr 
        35                  40                  45  


<210>  23
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1 binding motif

<400>  23

Gly Tyr Ile Cys Leu Arg Asn Ser Leu Pro Lys Val Leu Asn Phe His 
1               5                   10                  15      


Asn Phe Leu Ala Trp Pro Phe Pro Asn Leu Pro Pro Leu Glu Ala Met 
            20                  25                  30          


Asp Met Val Glu Val Ile Tyr Ile Asn Arg 
        35                  40          


<210>  24
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1 binding motif

<400>  24

Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile Ser Val 
1               5                   10                  15      


Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr Val Ser 
            20                  25                  30          


Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu 
        35                  40          


<210>  25
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1 binding motif

<400>  25

Arg Arg Arg Lys Lys Leu Pro Ser Val Leu Leu Phe Lys Lys Pro Ser 
1               5                   10                  15      


Pro Phe Ile Phe Ile Ser Gln Arg Pro Ser Pro Glu Thr Gln Asp Thr 
            20                  25                  30          


Ile His Pro Leu Asp Glu Glu Ala Phe Leu Lys 
        35                  40              


<210>  26
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1 binding motif

<400>  26

Tyr Ile His Val Gly Lys Glu Lys His Pro Ala Asn Leu Ile Leu Ile 
1               5                   10                  15      


Tyr Gly Asn Glu Phe Asp Lys Arg Phe Phe Val Pro Ala Glu Lys Ile 
            20                  25                  30          


Val Ile Asn Phe Ile Thr Leu Asn Ile Ser Asp Asp Ser 
        35                  40                  45  


<210>  27
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1 binding motif

<400>  27

Arg Tyr Val Thr Lys Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln 
1               5                   10                  15      


Arg Val Leu Thr Phe Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu 
            20                  25                  30          


Ile Pro Val Phe Asp Leu Ser Gly Pro 
        35                  40      


<210>  28
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK2 binding motif

<400>  28

Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu 
1               5                   10                  15      


Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu 
            20                  25                  30          


Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn 
        35                  40              


<210>  29
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK2 binding motif

<400>  29

Tyr Trp Phe His Thr Pro Pro Ser Ile Pro Leu Gln Ile Glu Glu Tyr 
1               5                   10                  15      


Leu Lys Asp Pro Thr Gln Pro Ile Leu Glu Ala Leu Asp Lys Asp Ser 
            20                  25                  30          


Ser Pro Lys Asp Asp Val Trp Asp Ser Val Ser Ile Ile Ser Phe Pro 
        35                  40                  45              


Glu 
    


<210>  30
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK2 binding motif

<400>  30

Tyr Ala Phe Ser Pro Arg Asn Ser Leu Pro Gln His Leu Lys Glu Phe 
1               5                   10                  15      


Leu Gly His Pro His His Asn Thr Leu Leu Phe Phe Ser Phe Pro Leu 
            20                  25                  30          


Ser Asp Glu Asn Asp Val Phe Asp Lys Leu Ser Val Ile Ala Glu Asp 
        35                  40                  45              


Ser Glu Ser 
    50      


<210>  31
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2RB truncated - Y510

<400>  31

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
65                  70                  75                  80  


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
                85                  90                  


<210>  32
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2RB truncated - Y510 & Y392

<400>  32

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Asp Ala Tyr Cys Thr Phe Pro Ser 
65                  70                  75                  80  


Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser 
                85                  90                  95      


Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met 
            100                 105                 110         


Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro 
        115                 120                 125             


Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro 
    130                 135                 140                 


Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala 
145                 150                 155                 160 


Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln 
                165                 170                 175     


Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala 
            180                 185                 190         


Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200                 205             


<210>  33
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK3 motif

<400>  33

Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile 
    50          


<210>  34
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK3 motif

<400>  34

Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly 
    50                  55                  60                  


Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr 
65                  70                  75                  80  


Thr Leu Lys Pro Glu Thr 
                85      


<210>  35
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 Transmembrane domain

<400>  35

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  36
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a TM domain

<400>  36

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  37
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified CD8a hinge plus CD8a TM domain for CAR

<400>  37

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
    50                  55                  60                  


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
65                  70                  75                  80  


Arg 
    


<210>  38
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified CD8a hinge

<400>  38

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Asp 
    50                  


<210>  39
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild type CD8a hinge

<400>  39

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg 
        


<210>  40
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge and transmembrane

<400>  40

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val 
65      


<210>  41
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RQR8

<400>  41

Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
            20                  25                  30          


Pro Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser Asn Pro Ser Leu 
        35                  40                  45              


Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    50                  55                  60                  


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
65                  70                  75                  80  


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                85                  90                  95      


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            100                 105                 110         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg 
        115                 120                 125             


Val Cys Lys Cys Pro Arg Pro Val Val 
    130                 135         


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  42

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  43

Glu Thr Ser Gly Gly Gly Gly Ser Arg Leu 
1               5                   10  


<210>  44
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  44

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  45

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  46

Gly Gly Gly Gly Ser 
1               5   


<210>  47
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  47

Gly Gly Gly Ser 
1               


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  48

Gly Gly Gly Gly Gly Ser 
1               5       


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  49

Gly Gly Gly Gly Gly Gly Ser 
1               5           


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  50

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  51

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  52
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  52

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  53

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  54

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  55
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  55

Ser Gly Gly Gly Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10                  15      


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  56

Ser Gly Gly Gly Leu Leu Leu Leu Leu Leu Leu Leu Gly Gly Gly Ser 
1               5                   10                  15      


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  57

Ser Gly Gly Gly Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gly Ser 
1               5                   10                  15      


<210>  58
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  58

Ser Gly Gly Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Gly Ser 
            20                  


<210>  59
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  59

Ser Gly Ala Leu Gly Gly Leu Ala Leu Ala Gly Leu Leu Leu Ala Gly 
1               5                   10                  15      


Leu Gly Leu Gly Ala Ala Gly Ser 
            20                  


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  60

Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Pro Ala Arg 
1               5                   10                  


<210>  61
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  61

Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Pro Ala Arg Ser Leu 
1               5                   10                  15      


Ser Leu Ser Pro Gly Gly Gly Gly Gly 
            20                  25  


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  62

Gly Ser Ser Gly Ser Ser 
1               5       


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  63

Gly Ser Ser Ser Ser Ser Ser 
1               5           


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  64

Gly Gly Ser Ser Ser Ser 
1               5       


<210>  65
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  65

Gly Ser Ser Ser Ser Ser 
1               5       


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  66

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  67

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  68

Gly Gly Gly Gly Gly 
1               5   


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  69

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  70
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  70

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  71

Gly Gly Gly Gly Gly Gly Gly 
1               5           


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  72

Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   


<210>  73
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  73

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp 
            20  


<210>  74
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A peptide - cleavage domain

<400>  74

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  75
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A  peptide - cleavage domain

<400>  75

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  76
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A peptide - cleavage domain

<400>  76

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  77
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A peptide - cleavage domain

<400>  77

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  78
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  78

Arg Xaa Xaa Arg 
1               


<210>  79
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site

<400>  79

Arg Arg Lys Arg 
1               


<210>  80
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2RB endodomain

<400>  80

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  81
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta

<400>  81

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  82
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 intracellular signalling

<400>  82

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  83
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD27 intracellular signalling

<400>  83

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  84
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT3 signal


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  84

Tyr Xaa Xaa Gln 
1               


<210>  85
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT3 signal

<400>  85

Tyr Arg His Gln 
1               


<210>  86
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example construct (RQR8-frb-fkbp12-IL2RB truncated)

<400>  86

Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
            20                  25                  30          


Pro Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser Asn Pro Ser Leu 
        35                  40                  45              


Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    50                  55                  60                  


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
65                  70                  75                  80  


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                85                  90                  95      


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            100                 105                 110         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg 
        115                 120                 125             


Val Cys Lys Cys Pro Arg Pro Val Val Met Ala Ser Arg Ile Leu Trp 
    130                 135                 140                 


His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe 
145                 150                 155                 160 


Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu His 
                165                 170                 175     


Ala Met Met Trp Glu Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn 
            180                 185                 190         


Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys 
        195                 200                 205             


Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu 
    210                 215                 220                 


Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Leu Glu Tyr Ser Gly Gly 
225                 230                 235                 240 


Gly Ser Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
                245                 250                 255     


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
            260                 265                 270         


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
        275                 280                 285             


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
    290                 295                 300                 


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
305                 310                 315                 320 


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
                325                 330                 335     


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn 
        355                 360                 365             


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
    370                 375                 380                 


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
385                 390                 395                 400 


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
                405                 410                 415     


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
            420                 425                 430         


Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
        435                 440                 445             


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
    450                 455                 460     


<210>  87
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK3 reverse orientation

<400>  87

Ile Glu Ser Val Leu Cys Leu Arg Glu Ser Tyr Asp Pro Gln Leu Ser 
1               5                   10                  15      


Glu Ala Leu Gly Lys Ser Val Gly Ser Trp Ala Ser Phe Asn Gly His 
            20                  25                  30          


Tyr Glu Thr Val Leu Asp Glu Leu Asn Lys Leu Thr Pro Ile Arg Pro 
        35                  40                  45              


Met Thr Arg Glu 
    50          


<210>  88
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP Sequence in SEQ ID NO. 1 of WO2016/135470

<400>  88

Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
1               5                   10                  15      


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
            20                  25                  30          


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
        35                  40                  45              


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
    50                  55                  60                  


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
65                  70                  75                  80  


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
                85                  90          


<210>  89
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP Sequence in SEQ ID NO.2 of WO2016/135470

<400>  89

Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105                 110 


<210>  90
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ser Glu Pro Lys Ala Ile Asp Pro Lys Leu Ser Thr Thr Asp Arg 
1               5                   10                  15      


Val Val Lys Ala Val Pro Phe Pro Pro Ser His Arg Leu Thr Ala Lys 
            20                  25                  30          


Glu Val Phe Asp Asn Asp Gly Lys Pro Arg Val Asp Ile Leu Lys Ala 
        35                  40                  45              


His Leu Met Lys Glu Gly Arg Leu Glu Glu Ser Val Ala Leu Arg Ile 
    50                  55                  60                  


Ile Thr Glu Gly Ala Ser Ile Leu Arg Gln Glu Lys Asn Leu Leu Asp 
65                  70                  75                  80  


Ile Asp Ala Pro Val Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe 
                85                  90                  95      


Asp Leu Met Lys Leu Phe Glu Val Gly Gly Ser Pro Ala Asn Thr Arg 
            100                 105                 110         


Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu 
        115                 120                 125             


Cys Val Leu Tyr Leu Trp Ala Leu Lys Ile Leu Tyr Pro Lys Thr Leu 
    130                 135                 140                 


Phe Leu Leu Arg Gly Asn His Glu Cys Arg His Leu Thr Glu Tyr Phe 
145                 150                 155                 160 


Thr Phe Lys Gln Glu Cys Lys Ile Lys Tyr Ser Glu Arg Val Tyr Asp 
                165                 170                 175     


Ala Cys Met Asp Ala Phe Asp Cys Leu Pro Leu Ala Ala Leu Met Asn 
            180                 185                 190         


Gln Gln Phe Leu Cys Val His Gly Gly Leu Ser Pro Glu Ile Asn Thr 
        195                 200                 205             


Leu Asp Asp Ile Arg Lys Leu Asp Arg Phe Lys Glu Pro Pro Ala Tyr 
    210                 215                 220                 


Gly Pro Met Cys Asp Ile Leu Trp Ser Asp Pro Leu Glu Asp Phe Gly 
225                 230                 235                 240 


Asn Glu Lys Thr Gln Glu His Phe Thr His Asn Thr Val Arg Gly Cys 
                245                 250                 255     


Ser Tyr Phe Tyr Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln His Asn 
            260                 265                 270         


Asn Leu Leu Ser Ile Leu Arg Ala His Glu Ala Gln Asp Ala Gly Tyr 
        275                 280                 285             


Arg Met Tyr Arg Lys Ser Gln Thr Thr Gly Phe Pro Ser Leu Ile Thr 
    290                 295                 300                 


Ile Phe Ser Ala Pro Asn Tyr Leu Asp Val Tyr Asn Asn Lys Ala Ala 
305                 310                 315                 320 


Val Leu Lys Tyr Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys 
                325                 330                 335     


Ser Pro His Pro Tyr Trp Leu Pro Asn Phe Met Asp Val Phe Thr Trp 
            340                 345                 350         


Ser Leu Pro Phe Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val 
        355                 360                 365             


Leu Asn Ile Cys Ser Asp Asp Glu Leu Gly Ser Glu Glu Asp Gly Phe 
    370                 375                 380                 


Asp Gly Ala Thr Ala Ala Ala Arg Lys Glu Val Ile Arg Asn Lys Ile 
385                 390                 395                 400 


Arg Ala Ile Gly Lys Met Ala Arg Val Phe Ser Val Leu Arg Glu Glu 
                405                 410                 415     


Ser Glu Ser Val Leu Thr Leu Lys Gly Leu Thr Pro Thr Gly Met Leu 
            420                 425                 430         


Pro Ser Gly Val Leu Ser Gly Gly Lys Gln Thr Leu Gln Ser Ala Thr 
        435                 440                 445             


Val Glu Ala Ile Glu Ala Asp Glu Ala Ile Lys Gly Phe Ser Pro Gln 
    450                 455                 460                 


His Lys Ile Thr Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn 
465                 470                 475                 480 


Glu Arg Met Pro Pro Arg Arg Asp Ala Met Pro Ser Asp Ala Asn Leu 
                485                 490                 495     


Asn Ser Ile Asn Lys Ala Leu Thr Ser Glu Thr Asn Gly Thr Asp Ser 
            500                 505                 510         


Asn Gly Ser Asn Ser Ser Asn Ile Gln 
        515                 520     


<210>  91
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Leu Glu 
                165 


<210>  92
<211>  260
<212>  PRT
<213>  Nicotiana tabacum

<400>  92

Met Ala Val Ala Pro Thr Ala Arg Glu Glu Asn Val Tyr Met Ala Lys 
1               5                   10                  15      


Leu Ala Glu Gln Ala Glu Arg Tyr Glu Glu Met Val Glu Phe Met Glu 
            20                  25                  30          


Lys Val Ser Asn Ser Leu Gly Ser Glu Glu Leu Thr Val Glu Glu Arg 
        35                  40                  45              


Asn Leu Leu Ser Val Ala Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala 
    50                  55                  60                  


Ser Trp Arg Ile Ile Ser Ser Ile Glu Gln Lys Glu Glu Ser Arg Gly 
65                  70                  75                  80  


Asn Glu Glu His Val Asn Ser Ile Arg Glu Tyr Arg Ser Lys Ile Glu 
                85                  90                  95      


Asn Glu Leu Ser Lys Ile Cys Asp Gly Ile Leu Lys Leu Leu Asp Ala 
            100                 105                 110         


Lys Leu Ile Pro Ser Ala Ala Ser Gly Asp Ser Lys Val Phe Tyr Leu 
        115                 120                 125             


Lys Met Lys Gly Asp Tyr His Arg Tyr Leu Ala Glu Phe Lys Thr Gly 
    130                 135                 140                 


Ala Glu Arg Lys Glu Ala Ala Glu Ser Thr Leu Thr Ala Tyr Lys Ala 
145                 150                 155                 160 


Ala Gln Asp Ile Ala Thr Thr Glu Leu Ala Pro Thr His Pro Ile Arg 
                165                 170                 175     


Leu Gly Leu Ala Leu Asn Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn 
            180                 185                 190         


Ser Pro Asp Arg Ala Cys Asn Leu Ala Lys Gln Ala Phe Asp Glu Ala 
        195                 200                 205             


Ile Ala Glu Leu Asp Thr Leu Gly Glu Glu Ser Tyr Lys Asp Ser Thr 
    210                 215                 220                 


Leu Ile Met Gln Leu Leu Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp 
225                 230                 235                 240 


Met Gln Asp Asp Gly Ala Asp Glu Ile Lys Glu Asp Pro Lys Pro Asp 
                245                 250                 255     


Glu Ala Lys Asn 
            260 


<210>  93
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C terminal 52 amino acids of Tobacco plasma membrane H+ ATPase 
       (PMA2)

<400>  93

Thr Asn Phe Asn Glu Leu Asn Gln Leu Ala Glu Glu Ala Lys Arg Arg 
1               5                   10                  15      


Ala Glu Ile Ala Arg Gln Arg Glu Leu His Thr Leu Lys Gly His Val 
            20                  25                  30          


Glu Ser Val Val Lys Leu Lys Gly Leu Asp Ile Glu Thr Ile Gln Gln 
        35                  40                  45              


Ser Tyr Thr Val 
    50          


<210>  94
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNa12 GQ463594

<400>  94

Met Ser Glu Pro Lys Ala Ile Asp Pro Lys Leu Ser Thr Thr Asp Arg 
1               5                   10                  15      


Val Val Lys Ala Val Pro Phe Pro Pro Ser His Arg Leu Thr Ala Lys 
            20                  25                  30          


Glu Val Phe Asp Asn Asp Gly Lys Pro Arg Val Asp Ile Leu Lys Ala 
        35                  40                  45              


His Leu Met Lys Glu Gly Arg Leu Glu Glu Ser Val Ala Leu Arg Ile 
    50                  55                  60                  


Ile Thr Glu Gly Ala Ser Ile Leu Arg Gln Glu Lys Asn Leu Leu Asp 
65                  70                  75                  80  


Ile Asp Ala Pro Val Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe 
                85                  90                  95      


Asp Leu Met Lys Leu Phe Glu Val Gly Gly Ser Pro Ala Asn Thr Arg 
            100                 105                 110         


Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu 
        115                 120                 125             


Cys Val Leu Tyr Leu Trp Ala Leu Lys Ile Leu Tyr Pro Lys Thr Leu 
    130                 135                 140                 


Phe Leu Leu Arg Gly Asn His Glu Cys Arg His Leu Thr Glu Tyr Phe 
145                 150                 155                 160 


Thr Phe Lys Gln Glu Cys Lys Ile Lys Tyr Ser Glu Arg Val Tyr Asp 
                165                 170                 175     


Ala Cys Met Asp Ala Phe Asp Cys Leu Pro Leu Ala Ala Leu Met Asn 
            180                 185                 190         


Gln Gln Phe Leu Cys Val His Gly Gly Leu Ser Pro Glu Ile Asn Thr 
        195                 200                 205             


Leu Asp Asp Ile Arg Lys Leu Asp Arg Phe Lys Glu Pro Pro Ala Tyr 
    210                 215                 220                 


Gly Pro Met Cys Asp Ile Leu Trp Ser Asp Pro Leu Glu Asp Phe Gly 
225                 230                 235                 240 


Asn Glu Lys Thr Gln Glu His Phe Thr His Asn Thr Val Arg Gly Cys 
                245                 250                 255     


Ser Tyr Phe Tyr Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln His Asn 
            260                 265                 270         


Asn Leu Leu Ser Ile Leu Arg Ala His Glu Ala Gln Asp Ala Gly Tyr 
        275                 280                 285             


Arg Met Tyr Arg Lys Ser Gln Thr Thr Gly Phe Pro Ser Leu Ile Thr 
    290                 295                 300                 


Ile Phe Ser Ala Pro Asn Tyr Leu Asp Val Tyr Asn Asn Lys Ala Ala 
305                 310                 315                 320 


Val Leu Lys Tyr Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys 
                325                 330                 335     


Ser Pro His Pro Tyr Trp Leu Pro Asn Phe Met Asp Val Phe Glu Trp 
            340                 345                 350         


Ser Ala Pro Phe Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val 
        355                 360                 365             


Leu Asn Ile Cys Ser Asp Asp Glu Leu Gly Ser Glu Glu Asp Gly Phe 
    370                 375                 380                 


Asp Gly Ala Thr Ala Ala Ala Arg Lys Glu Val Ile Arg Asn Lys Ile 
385                 390                 395                 400 


Arg Ala Ile Gly Lys Met Ala Arg Val Phe Ser Val Leu Arg Glu Glu 
                405                 410                 415     


Ser Glu Ser Val Leu Thr Leu Lys Gly Leu Thr Pro Thr Gly Met Leu 
            420                 425                 430         


Pro Ser Gly Val Leu Ser Gly Gly Lys Gln Thr Leu Gln Ser Ala Thr 
        435                 440                 445             


Val Glu Ala Ile Glu Ala Asp Glu Ala Ile Lys Gly Phe Ser Pro Gln 
    450                 455                 460                 


His Lys Ile Thr Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn 
465                 470                 475                 480 


Glu Arg Met Pro Pro Arg Arg Asp Ala Met Pro Ser Asp Ala Asn Leu 
                485                 490                 495     


Asn Ser Ile Asn Lys Ala Leu Thr Ser Glu Thr Asn Gly Thr Asp Ser 
            500                 505                 510         


Asn Gly Ser Asn Ser Ser Asn Ile Gln 
        515                 520     


<210>  95
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNa22 GQ463595

<400>  95

Met Ser Glu Pro Lys Ala Ile Asp Pro Lys Leu Ser Thr Thr Asp Arg 
1               5                   10                  15      


Val Val Lys Ala Val Pro Phe Pro Pro Ser His Arg Leu Thr Ala Lys 
            20                  25                  30          


Glu Val Phe Asp Asn Asp Gly Lys Pro Arg Val Asp Ile Leu Lys Ala 
        35                  40                  45              


His Leu Met Lys Glu Gly Arg Leu Glu Glu Ser Val Ala Leu Arg Ile 
    50                  55                  60                  


Ile Thr Glu Gly Ala Ser Ile Leu Arg Gln Glu Lys Asn Leu Leu Asp 
65                  70                  75                  80  


Ile Asp Ala Pro Val Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe 
                85                  90                  95      


Asp Leu Met Lys Leu Phe Glu Val Gly Gly Ser Pro Ala Asn Thr Arg 
            100                 105                 110         


Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu 
        115                 120                 125             


Cys Val Leu Tyr Leu Trp Ala Leu Lys Ile Leu Tyr Pro Lys Thr Leu 
    130                 135                 140                 


Phe Leu Leu Arg Gly Asn His Glu Cys Arg His Leu Thr Glu Tyr Phe 
145                 150                 155                 160 


Thr Phe Lys Gln Glu Cys Lys Ile Lys Tyr Ser Glu Arg Val Tyr Asp 
                165                 170                 175     


Ala Cys Met Asp Ala Phe Asp Cys Leu Pro Leu Ala Ala Leu Met Asn 
            180                 185                 190         


Gln Gln Phe Leu Cys Val His Gly Gly Leu Ser Pro Glu Ile Asn Thr 
        195                 200                 205             


Leu Asp Asp Ile Arg Lys Leu Asp Arg Phe Lys Glu Pro Pro Ala Tyr 
    210                 215                 220                 


Gly Pro Met Cys Asp Ile Leu Trp Ser Asp Pro Leu Glu Asp Phe Gly 
225                 230                 235                 240 


Asn Glu Lys Thr Gln Glu His Phe Thr His Asn Thr Val Arg Gly Cys 
                245                 250                 255     


Ser Tyr Phe Tyr Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln His Asn 
            260                 265                 270         


Asn Leu Leu Ser Ile Leu Arg Ala His Glu Ala Gln Asp Ala Gly Tyr 
        275                 280                 285             


Arg Met Tyr Arg Lys Ser Gln Thr Thr Gly Phe Pro Ser Leu Ile Thr 
    290                 295                 300                 


Ile Phe Ser Ala Pro Asn Tyr Leu Asp Arg Tyr Asn Asn Lys Ala Ala 
305                 310                 315                 320 


Val Leu Lys Tyr Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys 
                325                 330                 335     


Ser Pro His Pro Phe Trp Leu Pro Asn Phe Met Asp Val Phe Thr Trp 
            340                 345                 350         


Ser Leu Pro Phe Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val 
        355                 360                 365             


Leu Asn Ile Cys Ser Asp Asp Glu Leu Gly Ser Glu Glu Asp Gly Phe 
    370                 375                 380                 


Asp Gly Ala Thr Ala Ala Ala Arg Lys Glu Val Ile Arg Asn Lys Ile 
385                 390                 395                 400 


Arg Ala Ile Gly Lys Met Ala Arg Val Phe Ser Val Leu Arg Glu Glu 
                405                 410                 415     


Ser Glu Ser Val Leu Thr Leu Lys Gly Leu Thr Pro Thr Gly Met Leu 
            420                 425                 430         


Pro Ser Gly Val Leu Ser Gly Gly Lys Gln Thr Leu Gln Ser Ala Thr 
        435                 440                 445             


Val Glu Ala Ile Glu Ala Asp Glu Ala Ile Lys Gly Phe Ser Pro Gln 
    450                 455                 460                 


His Lys Ile Thr Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn 
465                 470                 475                 480 


Glu Arg Met Pro Pro Arg Arg Asp Ala Met Pro Ser Asp Ala Asn Leu 
                485                 490                 495     


Asn Ser Ile Asn Lys Ala Leu Thr Ser Glu Thr Asn Gly Thr Asp Ser 
            500                 505                 510         


Asn Gly Ser Asn Ser Ser Asn Ile Gln 
        515                 520     


<210>  96
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNb30 GQ463597

<400>  96

Met Gly Asn Glu Ala Ser Tyr Pro Leu Glu Met Cys Ser His Phe Asp 
1               5                   10                  15      


Ala Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys Leu Asp Leu 
            20                  25                  30          


Asp Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser Leu Pro Glu 
        35                  40                  45              


Leu Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile Phe Asp Thr 
    50                  55                  60                  


Asp Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu Gly Val Ser 
65                  70                  75                  80  


Gln Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg Phe Ala Phe 
                85                  90                  95      


Arg Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn Gly Glu Leu 
            100                 105                 110         


Phe Gln Val Leu Lys Met Met Val Gly Asn Asn Thr Lys Leu Ala Asp 
        115                 120                 125             


Thr Gln Leu Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp Lys 
    130                 135                 140                 


Asp Gly Asp Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val Gly 
145                 150                 155                 160 


Gly Leu Asp Ile His Lys Lys Met Val Val Asp Val 
                165                 170         


<210>  97
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNa

<400>  97

Met Ser Glu Pro Lys Ala Ile Asp Pro Lys Leu Ser Thr Thr Asp Arg 
1               5                   10                  15      


Val Val Lys Ala Val Pro Phe Pro Pro Ser His Arg Leu Thr Ala Lys 
            20                  25                  30          


Glu Val Phe Asp Asn Asp Gly Lys Pro Arg Val Asp Ile Leu Lys Ala 
        35                  40                  45              


His Leu Met Lys Glu Gly Arg Leu Glu Glu Ser Val Ala Leu Arg Ile 
    50                  55                  60                  


Ile Thr Glu Gly Ala Ser Ile Leu Arg Gln Glu Lys Asn Leu Leu Asp 
65                  70                  75                  80  


Ile Asp Ala Pro Val Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe 
                85                  90                  95      


Asp Leu Met Lys Leu Phe Glu Val Gly Gly Ser Pro Ala Asn Thr Arg 
            100                 105                 110         


Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu 
        115                 120                 125             


Cys Val Leu Tyr Leu Trp Ala Leu Lys Ile Leu Tyr Pro Lys Thr Leu 
    130                 135                 140                 


Phe Leu Leu Arg Gly Asn His Glu Cys Arg His Leu Thr Glu Tyr Phe 
145                 150                 155                 160 


Thr Phe Lys Gln Glu Cys Lys Ile Lys Tyr Ser Glu Arg Val Tyr Asp 
                165                 170                 175     


Ala Cys Met Asp Ala Phe Asp Cys Leu Pro Leu Ala Ala Leu Met Asn 
            180                 185                 190         


Gln Gln Phe Leu Cys Val His Gly Gly Leu Ser Pro Glu Ile Asn Thr 
        195                 200                 205             


Leu Asp Asp Ile Arg Lys Leu Asp Arg Phe Lys Glu Pro Pro Ala Tyr 
    210                 215                 220                 


Gly Pro Met Cys Asp Ile Leu Trp Ser Asp Pro Leu Glu Asp Phe Gly 
225                 230                 235                 240 


Asn Glu Lys Thr Gln Glu His Phe Thr His Asn Thr Val Arg Gly Cys 
                245                 250                 255     


Ser Tyr Phe Tyr Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln His Asn 
            260                 265                 270         


Asn Leu Leu Ser Ile Leu Arg Ala His Glu Ala Gln Asp Ala Gly Tyr 
        275                 280                 285             


Arg Met Tyr Arg Lys Ser Gln Thr Thr Gly Phe Pro Ser Leu Ile Thr 
    290                 295                 300                 


Ile Phe Ser Ala Pro Asn Tyr Leu Asp Val Tyr Asn Asn Lys Ala Ala 
305                 310                 315                 320 


Val Leu Lys Tyr Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys 
                325                 330                 335     


Ser Pro His Pro Tyr Trp Leu Pro Asn Phe Met Asp Val Phe Thr Trp 
            340                 345                 350         


Ser Leu Pro Phe Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val 
        355                 360                 365             


Leu Asn Ile Cys Ser Asp Asp Glu Leu Gly Ser Glu Glu Asp Gly Phe 
    370                 375                 380                 


Asp Gly Ala Thr Ala Ala Ala Arg Lys Glu Val Ile Arg Asn Lys Ile 
385                 390                 395                 400 


Arg Ala Ile Gly Lys Met Ala Arg Val Phe Ser Val Leu Arg Glu Glu 
                405                 410                 415     


Ser Glu Ser Val Leu Thr Leu Lys Gly Leu Thr Pro Thr Gly Met Leu 
            420                 425                 430         


Pro Ser Gly Val Leu Ser Gly Gly Lys Gln Thr Leu Gln Ser Ala Thr 
        435                 440                 445             


Val Glu Ala Ile Glu Ala Asp Glu Ala Ile Lys Gly Phe Ser Pro Gln 
    450                 455                 460                 


His Lys Ile Thr Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn 
465                 470                 475                 480 


Glu Arg Met Pro Pro Arg Arg Asp Ala Met Pro Ser Asp Ala Asn Leu 
                485                 490                 495     


Asn Ser Ile Asn Lys Ala Leu Thr Ser Glu Thr Asn Gly Thr Asp Ser 
            500                 505                 510         


Asn Gly Ser Asn Ser Ser Asn Ile Gln 
        515                 520     


<210>  98
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNb

<400>  98

Met Gly Asn Glu Ala Ser Tyr Pro Leu Glu Met Cys Ser His Phe Asp 
1               5                   10                  15      


Ala Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys Leu Asp Leu 
            20                  25                  30          


Asp Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser Leu Pro Glu 
        35                  40                  45              


Leu Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile Phe Asp Thr 
    50                  55                  60                  


Asp Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu Gly Val Ser 
65                  70                  75                  80  


Gln Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg Phe Ala Phe 
                85                  90                  95      


Arg Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn Gly Glu Leu 
            100                 105                 110         


Phe Gln Val Leu Lys Met Met Val Gly Asn Asn Leu Lys Asp Thr Gln 
        115                 120                 125             


Leu Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp Lys Asp Gly 
    130                 135                 140                 


Asp Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val Gly Gly Leu 
145                 150                 155                 160 


Asp Ile His Lys Lys Met Val Val Asp Val 
                165                 170 


<210>  99
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pQTX-0353 (6aa linker)

<400>  99

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Glu Thr 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Arg Leu Cys Pro Tyr Ser Asn Pro Ser Leu 
        35                  40                  45              


Cys Ser Gly Gly Gly Gly Ser Met Ile Leu Trp His Glu Met Trp His 
    50                  55                  60                  


Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val 
65                  70                  75                  80  


Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg 
                85                  90                  95      


Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg 
            100                 105                 110         


Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly 
        115                 120                 125             


Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe 
    130                 135                 140                 


Arg Arg Ile Ser Lys Ser Gly Gly Gly Ser Gly Val Gln Val Glu Thr 
145                 150                 155                 160 


Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys 
                165                 170                 175     


Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser 
            180                 185                 190         


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
        195                 200                 205             


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
    210                 215                 220                 


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
225                 230                 235                 240 


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
                245                 250                 255     


Leu Leu Lys Leu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Ile Pro Trp Leu Gly His Leu Leu Val Gly 
        275                 280                 285             


Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn 
    290                 295                 300                 


Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr 
305                 310                 315                 320 


Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly 
                325                 330                 335     


Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser 
            340                 345                 350         


Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg 
        355                 360                 365             


Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
    370                 375                 380                 


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Thr Arg Ala 
385                 390                 395                 400 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
                405                 410                 415     


Gly Pro Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
            420                 425                 430         


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
        435                 440                 445             


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
    450                 455                 460                 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
465                 470                 475                 480 


Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
                485                 490                 495     


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
            500                 505                 510         


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
        515                 520                 525             


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
    530                 535                 540                 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
545                 550                 555                 560 


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
                565                 570                 575     


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
            580                 585                 590         


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
        595                 600                 605             


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
    610                 615                 620                 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
625                 630                 635                 640 


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
                645                 650                 655     


Lys 
    


<210>  100
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pQTX-0354 (17aa linker)

<400>  100

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Glu Thr 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Arg Leu Cys Pro Tyr Ser Asn Pro Ser Leu 
        35                  40                  45              


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Met Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
65                  70                  75                  80  


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
                85                  90                  95      


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
            100                 105                 110         


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
        115                 120                 125             


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
    130                 135                 140                 


Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
145                 150                 155                 160 


Ser Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
                165                 170                 175     


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
            180                 185                 190         


Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn 
        195                 200                 205             


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
    210                 215                 220                 


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
225                 230                 235                 240 


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
                245                 250                 255     


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe 
    290                 295                 300                 


Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly 
305                 310                 315                 320 


Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys 
                325                 330                 335     


Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp 
            340                 345                 350         


Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala 
        355                 360                 365             


Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln 
    370                 375                 380                 


Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln 
385                 390                 395                 400 


Gly Gln Asp Pro Thr His Leu Val Thr Arg Ala Thr Asn Phe Ser Leu 
                405                 410                 415     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Ser 
            420                 425                 430         


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
        435                 440                 445             


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
    450                 455                 460                 


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
465                 470                 475                 480 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr 
                485                 490                 495     


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
            500                 505                 510         


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
        515                 520                 525             


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
    530                 535                 540                 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
545                 550                 555                 560 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
                565                 570                 575     


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
            580                 585                 590         


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
        595                 600                 605             


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
    610                 615                 620                 


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
625                 630                 635                 640 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
                645                 650                 655     


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            660                 665             


<210>  101
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB 94 aa (DLL)

<400>  101

Met Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser 
1               5                   10                  15      


Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu 
            20                  25                  30          


Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu 
        35                  40                  45              


Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu 
    50                  55                  60                  


Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln 
65                  70                  75                  80  


Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90                  


<210>  102
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB 94aa (DLT)

<400>  102

Met Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser 
1               5                   10                  15      


Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu 
            20                  25                  30          


Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu 
        35                  40                  45              


Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu 
    50                  55                  60                  


Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln 
65                  70                  75                  80  


Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90                  


<210>  103
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB 99 aa (DLL)

<400>  103

Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
1               5                   10                  15      


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
            20                  25                  30          


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
        35                  40                  45              


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
    50                  55                  60                  


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
65                  70                  75                  80  


Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90                  95      


Leu Glu Tyr 
            


<210>  104
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pQTX-0564

<400>  104

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Trp Ser His Pro Gln Phe 
            20                  25                  30          


Glu Lys Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
        35                  40                  45              


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
    50                  55                  60                  


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
65                  70                  75                  80  


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
                85                  90                  95      


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
            100                 105                 110         


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
        115                 120                 125             


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ile Pro Trp 
    130                 135                 140                 


Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile 
145                 150                 155                 160 


Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys 
                165                 170                 175     


Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln 
            180                 185                 190         


Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro 
        195                 200                 205             


Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser 
    210                 215                 220                 


Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln 
225                 230                 235                 240 


Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu 
                245                 250                 255     


Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp 
            260                 265                 270         


Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr 
        275                 280                 285             


Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser 
    290                 295                 300                 


Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys 
305                 310                 315                 320 


Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu 
                325                 330                 335     


Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly 
            340                 345                 350         


Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp 
        355                 360                 365             


Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val 
    370                 375                 380                 


Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu 
385                 390                 395                 400 


Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg 
                405                 410                 415     


Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu 
            420                 425                 430         


Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro 
        435                 440                 445             


Thr His Leu Val Thr Arg Arg Arg Lys Arg Gly Ser Gly Ala Thr Asn 
    450                 455                 460                 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
465                 470                 475                 480 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
                485                 490                 495     


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            500                 505                 510         


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        515                 520                 525             


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    530                 535                 540                 


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
545                 550                 555                 560 


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                565                 570                 575     


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            580                 585                 590         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        595                 600                 605             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    610                 615                 620                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
625                 630                 635                 640 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                645                 650                 655     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            660                 665                 670         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        675                 680                 685             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    690                 695                 700                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
705                 710                 715                 


<210>  105
<211>  835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pQTX-0565

<400>  105

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Trp Ser His Pro Gln Phe 
            20                  25                  30          


Glu Lys Met Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
        35                  40                  45              


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
    50                  55                  60                  


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
65                  70                  75                  80  


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
                85                  90                  95      


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
            100                 105                 110         


Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
        115                 120                 125             


Ser Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
    130                 135                 140                 


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
145                 150                 155                 160 


Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn 
                165                 170                 175     


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
            180                 185                 190         


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
        195                 200                 205             


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
    210                 215                 220                 


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe 
            260                 265                 270         


Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly 
        275                 280                 285             


Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys 
    290                 295                 300                 


Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp 
305                 310                 315                 320 


Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala 
                325                 330                 335     


Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln 
            340                 345                 350         


Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser 
        355                 360                 365             


Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe 
    370                 375                 380                 


His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr 
385                 390                 395                 400 


Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala 
                405                 410                 415     


Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp 
            420                 425                 430         


Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser 
        435                 440                 445             


Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly 
    450                 455                 460                 


Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val 
465                 470                 475                 480 


Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val 
                485                 490                 495     


Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu 
            500                 505                 510         


Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe 
        515                 520                 525             


Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala 
    530                 535                 540                 


Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln 
545                 550                 555                 560 


Gly Gln Asp Pro Thr His Leu Val Thr Arg Arg Arg Lys Arg Gly Ser 
                565                 570                 575     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            580                 585                 590         


Asn Pro Gly Pro Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
        595                 600                 605             


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
    610                 615                 620                 


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
625                 630                 635                 640 


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
                645                 650                 655     


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
            660                 665                 670         


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
        675                 680                 685             


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
    690                 695                 700                 


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
705                 710                 715                 720 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
                725                 730                 735     


Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
            740                 745                 750         


Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
        755                 760                 765             


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
    770                 775                 780                 


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
785                 790                 795                 800 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
                805                 810                 815     


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
            820                 825                 830         


Leu Tyr Lys 
        835 


<210>  106
<211>  835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pQTX-0566

<400>  106

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Trp Ser His Pro Gln Phe 
            20                  25                  30          


Glu Lys Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
        35                  40                  45              


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
    50                  55                  60                  


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
65                  70                  75                  80  


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
                85                  90                  95      


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
            100                 105                 110         


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
        115                 120                 125             


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly Gly 
    130                 135                 140                 


Gly Ser Met Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
145                 150                 155                 160 


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
                165                 170                 175     


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
            180                 185                 190         


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
        195                 200                 205             


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu 
    210                 215                 220                 


Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe 
            260                 265                 270         


Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly 
        275                 280                 285             


Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys 
    290                 295                 300                 


Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp 
305                 310                 315                 320 


Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala 
                325                 330                 335     


Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln 
            340                 345                 350         


Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser 
        355                 360                 365             


Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe 
    370                 375                 380                 


His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr 
385                 390                 395                 400 


Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala 
                405                 410                 415     


Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp 
            420                 425                 430         


Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser 
        435                 440                 445             


Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly 
    450                 455                 460                 


Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val 
465                 470                 475                 480 


Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val 
                485                 490                 495     


Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu 
            500                 505                 510         


Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe 
        515                 520                 525             


Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala 
    530                 535                 540                 


Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln 
545                 550                 555                 560 


Gly Gln Asp Pro Thr His Leu Val Thr Arg Arg Arg Lys Arg Gly Ser 
                565                 570                 575     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            580                 585                 590         


Asn Pro Gly Pro Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
        595                 600                 605             


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
    610                 615                 620                 


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
625                 630                 635                 640 


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
                645                 650                 655     


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
            660                 665                 670         


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
        675                 680                 685             


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
    690                 695                 700                 


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
705                 710                 715                 720 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
                725                 730                 735     


Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
            740                 745                 750         


Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
        755                 760                 765             


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
    770                 775                 780                 


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
785                 790                 795                 800 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
                805                 810                 815     


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
            820                 825                 830         


Leu Tyr Lys 
        835 


<210>  107
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pQTX-0567

<400>  107

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Trp Ser His Pro Gln Phe Glu Lys Met Ile 
            20                  25                  30          


Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu 
        35                  40                  45              


Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro 
    50                  55                  60                  


Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser 
65                  70                  75                  80  


Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys 
                85                  90                  95      


Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp 
            100                 105                 110         


Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Val Val Ile Ser 
        115                 120                 125             


Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp 
    130                 135                 140                 


Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp 
145                 150                 155                 160 


Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser 
                165                 170                 175     


Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys 
            180                 185                 190         


Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro 
        195                 200                 205             


Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys 
    210                 215                 220                 


Tyr Thr Leu Lys Pro Glu Thr Thr Arg Arg Arg Lys Arg Gly Ser Gly 
225                 230                 235                 240 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
                245                 250                 255     


Pro Gly Pro Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile 
            260                 265                 270         


Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly 
        275                 280                 285             


His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly 
    290                 295                 300                 


Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe 
305                 310                 315                 320 


Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr 
                325                 330                 335     


Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro 
            340                 345                 350         


Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val 
        355                 360                 365             


Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr 
    370                 375                 380                 


Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met 
385                 390                 395                 400 


Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro 
                405                 410                 415     


Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys 
            420                 425                 430         


Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys 
        435                 440                 445             


Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp 
    450                 455                 460                 


Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg 
465                 470                 475                 480 


Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
                485                 490                 495 


<210>  108
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pQTX-0568

<400>  108

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Trp Ser His Pro Gln Phe Glu Lys Met Ile 
            20                  25                  30          


Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu 
        35                  40                  45              


Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro 
    50                  55                  60                  


Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser 
65                  70                  75                  80  


Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys 
                85                  90                  95      


Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp 
            100                 105                 110         


Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Ser Gly Gly Gly 
        115                 120                 125             


Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
    130                 135                 140                 


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
145                 150                 155                 160 


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
                165                 170                 175     


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
            180                 185                 190         


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
        195                 200                 205             


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
    210                 215                 220                 


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Val Ile 
                245                 250                 255     


Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe 
            260                 265                 270         


Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu 
        275                 280                 285             


Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val 
    290                 295                 300                 


Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu 
305                 310                 315                 320 


Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly 
                325                 330                 335     


Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro 
            340                 345                 350         


Cys Tyr Thr Leu Lys Pro Glu Thr Thr Arg Arg Arg Lys Arg Gly Ser 
        355                 360                 365             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    370                 375                 380                 


Asn Pro Gly Pro Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile 
385                 390                 395                 400 


Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn 
                405                 410                 415     


Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu 
            420                 425                 430         


Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro 
        435                 440                 445             


Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala 
    450                 455                 460                 


Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe 
465                 470                 475                 480 


Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly 
                485                 490                 495     


Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile 
            500                 505                 510         


Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val 
        515                 520                 525             


Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr 
    530                 535                 540                 


Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu 
545                 550                 555                 560 


Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala 
                565                 570                 575     


Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu 
            580                 585                 590         


Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu 
        595                 600                 605             


Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
    610                 615                 620                 


<210>  109
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pQTX-0569

<400>  109

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Trp Ser His Pro Gln Phe Glu Lys Gly Val 
            20                  25                  30          


Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg 
        35                  40                  45              


Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys 
    50                  55                  60                  


Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu 
65                  70                  75                  80  


Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met 
                85                  90                  95      


Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr 
            100                 105                 110         


Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val 
        115                 120                 125             


Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly Ser Met Ile 
    130                 135                 140                 


Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu 
145                 150                 155                 160 


Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro 
                165                 170                 175     


Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser 
            180                 185                 190         


Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys 
        195                 200                 205             


Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp 
    210                 215                 220                 


Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Val Ile 
                245                 250                 255     


Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe 
            260                 265                 270         


Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu 
        275                 280                 285             


Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val 
    290                 295                 300                 


Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu 
305                 310                 315                 320 


Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly 
                325                 330                 335     


Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro 
            340                 345                 350         


Cys Tyr Thr Leu Lys Pro Glu Thr Thr Arg Arg Arg Lys Arg Gly Ser 
        355                 360                 365             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    370                 375                 380                 


Asn Pro Gly Pro Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile 
385                 390                 395                 400 


Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn 
                405                 410                 415     


Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu 
            420                 425                 430         


Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro 
        435                 440                 445             


Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala 
    450                 455                 460                 


Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe 
465                 470                 475                 480 


Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly 
                485                 490                 495     


Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile 
            500                 505                 510         


Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val 
        515                 520                 525             


Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr 
    530                 535                 540                 


Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu 
545                 550                 555                 560 


Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala 
                565                 570                 575     


Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu 
            580                 585                 590         


Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu 
        595                 600                 605             


Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
    610                 615                 620                 


