                       SEQUENCE LISTING

<110>  Gadeta B.V.

<120>  IMPROVED IMMUNOTHERAPEUTICS AND USE THEREOF

<130>  P6099087PCT

<150>  EP20217167.4
<151>  2020-12-23

<150>  EP20217164.1
<151>  2020-12-23

<160>  222

<210>  1
<211>  205
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-EC

<400>  1
Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
1               5                   10                  15  

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                20                  25                  30  

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                35                  40                  45  

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                50                  55                  60  

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                65                  70                  75  

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                80                  85                  90  

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                95                  100                 105 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                110                 115                 120 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                125                 130                 135 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                140                 145                 150 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                155                 160                 165 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                170                 175                 180 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                185                 190                 195 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                200                 205 

<210>  2
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L

<400>  2
Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln 
1               5                   10                  15  

Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
                20                  25                  30  

Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile 
                35                  40                  45  

Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser 
                50                  55                  60  

Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro 
                65                  70                  75  

Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val 
                80                  85                  90  

Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr 
                95                  100                 105 

Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu 
                110                 115                 120 

Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                125                 130             

<210>  3
<211>  247
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86

<400>  3
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro 
                245         

<210>  4
<211>  212
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK

<400>  4
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Ser Ser Leu Pro Ala Arg Lys Pro Pro Asn Glu Pro His Val Tyr 
                200                 205                 210 

Leu Pro 
        

<210>  5
<211>  220
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Reverse 41BBL

<400>  5
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
1               5                   10                  15  

Pro Ala Phe Leu Leu Ile Pro Asp Gln Gly Met Phe Ala Gln Leu 
                20                  25                  30  

Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                35                  40                  45  

Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
                50                  55                  60  

Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
                65                  70                  75  

Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
                80                  85                  90  

Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                95                  100                 105 

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                110                 115                 120 

Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
                125                 130                 135 

Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                140                 145                 150 

Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
                155                 160                 165 

Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                170                 175                 180 

Ala Gly Leu Pro Ser Pro Arg Ser Glu Arg Leu Asp Leu Leu Gly 
                185                 190                 195 

Ala Pro Asp Asp Pro Ser Leu Glu Pro Gly Glu Arg Leu Arg Pro 
                200                 205                 210 

Ser Ala Ala Ser Gly Pro Ser Ala Arg Ala 
                215                 220 

<210>  6
<211>  347
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL  CD86 IgV domain

<400>  6
Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
1               5                   10                  15  

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                20                  25                  30  

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                35                  40                  45  

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                50                  55                  60  

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                65                  70                  75  

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                80                  85                  90  

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                95                  100                 105 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                110                 115                 120 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                125                 130                 135 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                140                 145                 150 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                155                 160                 165 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                170                 175                 180 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                185                 190                 195 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Ser Leu Asn Gly Gly 
                200                 205                 210 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                215                 220                 225 

Gly Gly Ser Gly Gly Gly Gly Ser Thr Ser Ala Pro Leu Lys Ile 
                230                 235                 240 

Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala 
                245                 250                 255 

Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln 
                260                 265                 270 

Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
                275                 280                 285 

Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe 
                290                 295                 300 

Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
                305                 310                 315 

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
                320                 325                 330 

Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
                335                 340                 345 

Ala Asn 
        

<210>  7
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD

<400>  7
Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15  

Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His 
                20                  25                  30  

Ser Thr Leu Ala Lys Ile 
                35      

<210>  8
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-REV

<400>  8
Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu Glu Gln Ile 
1               5                   10                  15  

Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His Ala Asp Pro 
                20                  25                  30  

Pro Leu Arg Gln Asp Arg 
                35      

<210>  9
<211>  63
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-TM

<400>  9
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly 
1               5                   10                  15  

Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln 
                20                  25                  30  

Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe 
                35                  40                  45  

Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu 
                50                  55                  60  

Ala Lys Ile 
            

<210>  10
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-ICD

<400>  10
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15  

Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                20                  25                  30  

Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40          

<210>  11
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-ICD-REV

<400>  11
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  




<210>  12
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NKp80-ICD

<400>  12
Met Gln Asp Glu Asp Gly Tyr Met Thr Leu Asn Val Gln Ser Lys 
1               5                   10                  15  

Lys Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr 
                20                  25                  30  

Ser Val Thr Leu His Trp 
                35      

<210>  13
<211>  224
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL18RAP-ICD

<400>  13
Ala Ala Ser Ala Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu 
1               5                   10                  15  

Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys 
                20                  25                  30  

Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe 
                35                  40                  45  

Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu 
                50                  55                  60  

Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu 
                65                  70                  75  

Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu 
                80                  85                  90  

Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile 
                95                  100                 105 

Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln 
                110                 115                 120 

Ala Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile 
                125                 130                 135 

Leu Ile Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His 
                140                 145                 150 

Leu Val Lys Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg 
                155                 160                 165 

Gly Leu Lys Ser Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met 
                170                 175                 180 

Arg Tyr His Met Pro Val Lys Asn Ser Gln Gly Phe Thr Trp Asn 
                185                 190                 195 

Gln Leu Arg Ile Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser 
                200                 205                 210 

Arg Thr Glu Thr Thr Gly Arg Ser Ser Gln Pro Lys Glu Trp 
                215                 220                 

<210>  14
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-ICD-TM

<400>  14
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe 
1               5                   10                  15  

Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly 
                20                  25                  30  

Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                35                  40                  45  

Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                50                  55                  60  

Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                65                  

<210>  15
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-ALYLLR

<400>  15
Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu Glu Gln Ile 
1               5                   10                  15  

Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His Ala Asp Pro 
                20                  25                  30  

Pro Leu Arg Gln Asp Arg Arg Leu Leu Tyr Leu Ala 
                35                  40          

<210>  16
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-ALYLLR-REV

<400>  16
Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
1               5                   10                  15  

His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
                20                  25                  30  

Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                35                  40          

<210>  17
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRAF domain OX40

<400>  17
Pro Ile Gln Glu Glu Gln 
1               5       

<210>  18
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  YMTLN motif

<400>  18
Tyr Met Thr Leu Asn 
1               5   

<210>  19
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRAF domain 41BB

<400>  19
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
1               5                   10                  15  

Glu Glu Glu 
            

<210>  20
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-TM

<400>  20
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly 
1               5                   10                  15  

Pro Leu Ala Ile Leu Leu 
                20      

<210>  21
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L-TM

<400>  21
Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu 
1               5                   10                  15  

Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu 
                20                  25          

<210>  22
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-TM

<400>  22
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe 
1               5                   10                  15  

Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
                20                  25          

<210>  23
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-TM

<400>  23
Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala 
1               5                   10                  15  

Ala Cys Ala Val Phe Leu 
                20      

<210>  24
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NKp80-TM

<400>  24
Ile Leu Leu Gly Ile Ser Gly Thr Val Asn Gly Ile Leu Thr Leu 
1               5                   10                  15  

Thr Leu Ile Ser Leu Ile 
                20      

<210>  25
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86-TM

<400>  25
Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val 
1               5                   10                  15  

Phe Cys Leu Ile Leu Trp 
                20      

<210>  26
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL18RAP-TM

<400>  26
Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr Leu 
1               5                   10                  15  

Val Ala Val Leu 
                

<210>  27
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-TM

<400>  27
Gly Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala Leu Val Ala 
1               5                   10                  15  

Ala Ile Ile Phe Gly Val 
                20      

<210>  28
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  28
Thr Ser Gly Ser 
1               

<210>  29
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  29
Gly Gly Gly Gly Ser 
1               5   

<210>  30
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  30
Gly Gly Gly Ser 
1               

<210>  31
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  31
gg                                                                     2

<210>  32
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  32
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg 
1               5                   10                  15  

Ser Leu Asp 
            

<210>  33
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  33
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  

<210>  34
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  34
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          

<210>  35
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  35
Glu Ala Ala Ala Lys 
1               5   

<210>  36
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  36
Glu Ala Ala Ala Arg 
1               5   

<210>  37
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  37
Pro Ala Pro Ala Pro 
1               5   

<210>  38
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  38
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          

<210>  39
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  39
Ile Leu Thr His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr 
1               5                   10                  15  

Asn Ser Asn Asn Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala 
                20                  25                  30  

Gln Leu Glu Ala Gln Cys Gln Glu Pro Cys Lys Asp Thr Val Gln 
                35                  40                  45  

Ile His Asp Ile Thr Gly 
                50      

<210>  40
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  40
Gly Gly Ser 
1           

<210>  41
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  41
Ser Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15  

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Ser 
                20                  25                  30  




<210>  42
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  42
Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15  

Gly Gly Ser Leu Gln 
                20  

<210>  43
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  43
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
                20                  25      

<210>  44
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  44
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  




<210>  45
<211>  295
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40

<400>  45
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
                95                  100                 105 

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                110                 115                 120 

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                125                 130                 135 

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                140                 145                 150 

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                155                 160                 165 

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                170                 175                 180 

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                185                 190                 195 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                200                 205                 210 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                215                 220                 225 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                230                 235                 240 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                245                 250                 255 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                260                 265                 270 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                275                 280                 285 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                290                 295 

<210>  46
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL13W-OX40rev

<400>  46
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Thr Ser Gly Ser Trp Ala 
                35                  40                  45  

Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys 
                50                  55                  60  

Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala 
                65                  70                  75  

Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu 
                80                  85                  90  

Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                95                  100                 105 

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
                110                 115                 120 

Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
                125                 130                 135 

Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                140                 145                 150 

Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
                155                 160                 165 

Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                170                 175                 180 

His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                185                 190                 195 

Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
                200                 205                 210 

Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
                215                 220                 225 

Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                230                 235                 240 

Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
                245                 250                 255 

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                260                 265                 

<210>  47
<211>  288
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-NKp80

<400>  47
Met Gln Asp Glu Asp Gly Tyr Met Thr Leu Asn Val Gln Ser Lys 
1               5                   10                  15  

Lys Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr 
                20                  25                  30  

Ser Val Thr Leu His Trp Tyr Ala Ser Asp Ala Ser Leu Asp Pro 
                35                  40                  45  

Glu Ala Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val 
                50                  55                  60  

Leu Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu 
                65                  70                  75  

Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser 
                80                  85                  90  

Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg 
                95                  100                 105 

Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
                110                 115                 120 

Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                125                 130                 135 

Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
                140                 145                 150 

Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
                155                 160                 165 

Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
                170                 175                 180 

Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                185                 190                 195 

Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                200                 205                 210 

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
                215                 220                 225 

Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
                230                 235                 240 

Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
                245                 250                 255 

Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
                260                 265                 270 

Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro 
                275                 280                 285 

Arg Ser Glu 
            

<210>  48
<211>  264
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBLmincyto-NKp80

<400>  48
Met Gln Asp Glu Asp Gly Tyr Met Thr Leu Asn Val Gln Ser Lys 
1               5                   10                  15  

Lys Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr 
                20                  25                  30  

Ser Val Thr Leu His Trp Tyr Lys Trp Ala Leu Val Ala Gly Leu 
                35                  40                  45  

Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala 
                50                  55                  60  

Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
                65                  70                  75  

Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
                80                  85                  90  

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                95                  100                 105 

Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                110                 115                 120 

Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
                125                 130                 135 

Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
                140                 145                 150 

Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
                155                 160                 165 

Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                170                 175                 180 

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                185                 190                 195 

Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
                200                 205                 210 

Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                215                 220                 225 

Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
                230                 235                 240 

Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                245                 250                 255 

Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                260                 

<210>  49
<211>  231
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L-41BB

<400>  49
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  

Thr Ser Gly Ser Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly 
                50                  55                  60  

Asn Ala Ala Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val 
                65                  70                  75  

Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr 
                80                  85                  90  

Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro 
                95                  100                 105 

Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu 
                110                 115                 120 

Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys 
                125                 130                 135 

Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu 
                140                 145                 150 

Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu 
                155                 160                 165 

His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val 
                170                 175                 180 

Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
                185                 190                 195 

Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
                200                 205                 210 

Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro 
                215                 220                 225 

Gly Glu Phe Cys Val Leu 
                230     

<210>  50
<211>  231
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L-41BB

<400>  50
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  

Gly Gly Ser Ala Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly 
                50                  55                  60  

Asn Ala Ala Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val 
                65                  70                  75  

Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr 
                80                  85                  90  

Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro 
                95                  100                 105 

Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu 
                110                 115                 120 

Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys 
                125                 130                 135 

Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu 
                140                 145                 150 

Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu 
                155                 160                 165 

His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val 
                170                 175                 180 

Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
                185                 190                 195 

Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
                200                 205                 210 

Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro 
                215                 220                 225 

Gly Glu Phe Cys Val Leu 
                230     

<210>  51
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L-41BBrev

<400>  51
Met Leu Gly Leu Glu Cys Gly Gly Glu Glu Glu Glu Pro Phe Arg 
1               5                   10                  15  

Cys Ser Cys Gly Asp Glu Glu Gln Thr Thr Gln Val Pro Arg Met 
                20                  25                  30  

Phe Pro Gln Lys Phe Ile Tyr Leu Leu Lys Lys Arg Gly Arg Lys 
                35                  40                  45  

Leu Gly Gly Ser Ala Glu Arg Val Gln Pro Leu Glu Glu Asn Val 
                50                  55                  60  

Gly Asn Ala Ala Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu 
                65                  70                  75  

Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr 
                80                  85                  90  

Tyr Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr 
                95                  100                 105 

Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys 
                110                 115                 120 

Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met 
                125                 130                 135 

Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr 
                140                 145                 150 

Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser 
                155                 160                 165 

Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
                170                 175                 180 

Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                185                 190                 195 

Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp 
                200                 205                 210 

Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                215                 220                 225 

Pro Gly Glu Phe Cys Val Leu 
                230         

<210>  52
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86-OX40

<400>  52
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn 
                275                 280                 285 

Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
                290                 295                 300 

Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys 
                305                 310                 315 

Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe Gly 
                320                 325                 330 

Ser Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro 
                335                 340                 345 

Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
                350                 355                 360 

Ala His Ser Thr Leu Ala Lys Ile 
                365             

<210>  53
<211>  313
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86delP276-OX40

<400>  53
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Gly Arg Asp Gln Arg Leu Pro Pro Asp 
                275                 280                 285 

Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
                290                 295                 300 

Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                305                 310             

<210>  54
<211>  254
<212>  PRT
<213>  Homo sapiens

<220>
<223>  41BBL

<400>  54
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp 
1               5                   10                  15  

Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala 
                20                  25                  30  

Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys 
                35                  40                  45  

Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala 
                50                  55                  60  

Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu 
                65                  70                  75  

Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                80                  85                  90  

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
                95                  100                 105 

Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
                110                 115                 120 

Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                125                 130                 135 

Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
                140                 145                 150 

Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                155                 160                 165 

His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                170                 175                 180 

Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
                185                 190                 195 

Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
                200                 205                 210 

Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                215                 220                 225 

Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
                230                 235                 240 

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 

<210>  55
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-mincyto

<400>  55
Met Ser Lys Ser Thr Gly Ser Trp Ala Leu Val Ala Gly Leu Leu 
1               5                   10                  15  

Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys 
                20                  25                  30  

Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala 
                35                  40                  45  

Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
                50                  55                  60  

Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                65                  70                  75  

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
                80                  85                  90  

Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
                95                  100                 105 

Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
                110                 115                 120 

Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
                125                 130                 135 

Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg 
                140                 145                 150 

Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
                155                 160                 165 

Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
                170                 175                 180 

Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
                185                 190                 195 

His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
                200                 205                 210 

Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                215                 220                 225 

Gly Leu Pro Ser Pro Arg Ser Glu 
                230             

<210>  56
<211>  228
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL13W

<400>  56
Met Glu Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15  

Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser 
                20                  25                  30  

Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg 
                35                  40                  45  

Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
                50                  55                  60  

Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                65                  70                  75  

Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
                80                  85                  90  

Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
                95                  100                 105 

Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
                110                 115                 120 

Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                125                 130                 135 

Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                140                 145                 150 

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
                155                 160                 165 

Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
                170                 175                 180 

Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
                185                 190                 195 

Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
                200                 205                 210 

Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro 
                215                 220                 225 

Arg Ser Glu 
            

<210>  57
<211>  295
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40rev

<400>  57
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
                95                  100                 105 

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                110                 115                 120 

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                125                 130                 135 

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                140                 145                 150 

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                155                 160                 165 

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                170                 175                 180 

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                185                 190                 195 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                200                 205                 210 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                215                 220                 225 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                230                 235                 240 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                245                 250                 255 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                260                 265                 270 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                275                 280                 285 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                290                 295 

<210>  58
<211>  283
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-rev extra-OX40tm-cyto

<400>  58
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
1               5                   10                  15  

Pro Ala Phe Leu Leu Ile Pro Asp Gln Gly Met Phe Ala Gln Leu 
                20                  25                  30  

Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                35                  40                  45  

Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
                50                  55                  60  

Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
                65                  70                  75  

Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
                80                  85                  90  

Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                95                  100                 105 

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                110                 115                 120 

Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
                125                 130                 135 

Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                140                 145                 150 

Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
                155                 160                 165 

Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                170                 175                 180 

Ala Gly Leu Pro Ser Pro Arg Ser Glu Arg Leu Asp Leu Leu Gly 
                185                 190                 195 

Ala Pro Asp Asp Pro Ser Leu Glu Pro Gly Glu Arg Leu Arg Pro 
                200                 205                 210 

Ser Ala Ala Ser Gly Pro Ser Ala Arg Ala Val Ala Ala Ile Leu 
                215                 220                 225 

Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu 
                230                 235                 240 

Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp 
                245                 250                 255 

Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
                260                 265                 270 

Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                275                 280             

<210>  59
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBLmincyto-OX40

<400>  59
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Trp Ala 
                35                  40                  45  

Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys 
                50                  55                  60  

Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala 
                65                  70                  75  

Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu 
                80                  85                  90  

Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                95                  100                 105 

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
                110                 115                 120 

Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
                125                 130                 135 

Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                140                 145                 150 

Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
                155                 160                 165 

Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                170                 175                 180 

His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                185                 190                 195 

Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
                200                 205                 210 

Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
                215                 220                 225 

Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                230                 235                 240 

Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
                245                 250                 255 

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                260                 265                 

<210>  60
<211>  281
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL13W-OX40rev

<400>  60
Met Glu Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu Glu 
1               5                   10                  15  

Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His Ala 
                20                  25                  30  

Asp Pro Pro Leu Arg Gln Asp Arg Arg Leu Leu Trp Pro Pro Ala 
                35                  40                  45  

Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala 
                50                  55                  60  

Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
                65                  70                  75  

Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly 
                80                  85                  90  

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro 
                95                  100                 105 

Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
                110                 115                 120 

Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
                125                 130                 135 

Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly 
                140                 145                 150 

Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
                155                 160                 165 

Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
                170                 175                 180 

Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
                185                 190                 195 

Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                200                 205                 210 

Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
                215                 220                 225 

Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
                230                 235                 240 

Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
                245                 250                 255 

Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
                260                 265                 270 

Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                275                 280     

<210>  61
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-mincyto-OX40rev

<400>  61
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Thr Ser Gly Ser Trp Ala 
                35                  40                  45  

Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys 
                50                  55                  60  

Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala 
                65                  70                  75  

Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu 
                80                  85                  90  

Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                95                  100                 105 

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
                110                 115                 120 

Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
                125                 130                 135 

Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                140                 145                 150 

Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
                155                 160                 165 

Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                170                 175                 180 

His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                185                 190                 195 

Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
                200                 205                 210 

Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
                215                 220                 225 

Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                230                 235                 240 

Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
                245                 250                 255 

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                260                 265                 

<210>  62
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40ENrev

<400>  62
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Arg Leu Leu Tyr Leu Ala 
                35                  40                  45  

Thr Ser Gly Ser Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala 
                50                  55                  60  

Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro 
                65                  70                  75  

Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala 
                80                  85                  90  

Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala 
                95                  100                 105 

Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
                110                 115                 120 

Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
                125                 130                 135 

Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
                140                 145                 150 

Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
                155                 160                 165 

Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
                170                 175                 180 

Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
                185                 190                 195 

Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
                200                 205                 210 

Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                215                 220                 225 

Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
                230                 235                 240 

Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
                245                 250                 255 

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
                260                 265                 270 

His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
                275                 280                 285 

Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
                290                 295                 300 

Glu 
    

<210>  63
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40EN

<400>  63
Met Leu Gly Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro 
1               5                   10                  15  

Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
                20                  25                  30  

Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                35                  40                  45  

Thr Ser Gly Ser Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala 
                50                  55                  60  

Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro 
                65                  70                  75  

Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala 
                80                  85                  90  

Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala 
                95                  100                 105 

Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
                110                 115                 120 

Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
                125                 130                 135 

Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
                140                 145                 150 

Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
                155                 160                 165 

Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
                170                 175                 180 

Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
                185                 190                 195 

Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
                200                 205                 210 

Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                215                 220                 225 

Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
                230                 235                 240 

Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
                245                 250                 255 

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
                260                 265                 270 

His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
                275                 280                 285 

Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
                290                 295                 300 

Glu 
    

<210>  64
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBLmincyto-13alink-OX40

<400>  64
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Ser Leu Asn Gly Gly Gly 
                35                  40                  45  

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                50                  55                  60  

Gly Ser Gly Gly Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu 
                65                  70                  75  

Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp 
                80                  85                  90  

Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro 
                95                  100                 105 

Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
                110                 115                 120 

Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                125                 130                 135 

Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
                140                 145                 150 

Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
                155                 160                 165 

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
                170                 175                 180 

Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
                185                 190                 195 

Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
                200                 205                 210 

Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
                215                 220                 225 

Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu 
                230                 235                 240 

Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
                245                 250                 255 

Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
                260                 265                 270 

Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
                275                 280                 285 

Pro Ser Pro Arg Ser Glu 
                290     

<210>  65
<211>  209
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40Lmincyto-41BBrev

<400>  65
Met Leu Gly Leu Glu Cys Gly Gly Glu Glu Glu Glu Pro Phe Arg 
1               5                   10                  15  

Cys Ser Cys Gly Asp Glu Glu Gln Thr Thr Gln Val Pro Arg Met 
                20                  25                  30  

Phe Pro Gln Lys Phe Ile Tyr Leu Leu Lys Lys Arg Gly Arg Lys 
                35                  40                  45  

Leu Gly Gly Ser Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu 
                50                  55                  60  

Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala 
                65                  70                  75  

Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
                80                  85                  90  

Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser 
                95                  100                 105 

Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile 
                110                 115                 120 

Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe 
                125                 130                 135 

Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu 
                140                 145                 150 

Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met 
                155                 160                 165 

Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr 
                170                 175                 180 

Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu 
                185                 190                 195 

Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                200                 205                 

<210>  66
<211>  183
<212>  PRT
<213>  Homo sapiens

<220>
<223>  OX40L WT

<400>  66
Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala 
1               5                   10                  15  

Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val 
                20                  25                  30  

Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu 
                35                  40                  45  

His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln 
                50                  55                  60  

Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe 
                65                  70                  75  

Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn 
                80                  85                  90  

Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu 
                95                  100                 105 

Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln 
                110                 115                 120 

Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val 
                125                 130                 135 

Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr 
                140                 145                 150 

Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val 
                155                 160                 165 

Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe 
                170                 175                 180 

Cys Val Leu 
            

<210>  67
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40Lmincyto-41BB

<400>  67
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  

Gly Gly Ser Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly 
                50                  55                  60  

Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu 
                65                  70                  75  

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln 
                80                  85                  90  

Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
                95                  100                 105 

Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile 
                110                 115                 120 

Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser 
                125                 130                 135 

Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro 
                140                 145                 150 

Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val 
                155                 160                 165 

Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr 
                170                 175                 180 

Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu 
                185                 190                 195 

Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                200                 205             

<210>  68
<211>  329
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD86 WT

<400>  68
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn 
                275                 280                 285 

Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
                290                 295                 300 

Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys 
                305                 310                 315 

Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                320                 325                 

<210>  69
<211>  276
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86delP276

<400>  69
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro 
                275     

<210>  70
<211>  268
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86mincyto

<400>  70
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp 
                260                 265             

<210>  71
<211>  490
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86mincyto-IL18RAP

<400>  71
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Ser Ala 
                260                 265                 270 

Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr 
                275                 280                 285 

Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe Asp 
                290                 295                 300 

Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe Pro Ser Glu Ala 
                305                 310                 315 

Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu Ser Leu Phe Pro 
                320                 325                 330 

Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu Cys Leu Leu Glu 
                335                 340                 345 

Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu Asp Ile Val Ser 
                350                 355                 360 

Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile Leu Ser Pro Asn 
                365                 370                 375 

Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala Ala Val Asn 
                380                 385                 390 

Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile Lys Phe 
                395                 400                 405 

Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys Lys 
                410                 415                 420 

Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser 
                425                 430                 435 

Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His Met 
                440                 445                 450 

Pro Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile 
                455                 460                 465 

Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr 
                470                 475                 480 

Thr Gly Arg Ser Ser Gln Pro Lys Glu Trp 
                485                 490 

<210>  72
<211>  551
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86-IL18RAP

<400>  72
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn 
                275                 280                 285 

Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
                290                 295                 300 

Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys 
                305                 310                 315 

Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe Ser 
                320                 325                 330 

Ala Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg 
                335                 340                 345 

Thr Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe 
                350                 355                 360 

Asp Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe Pro Ser Glu 
                365                 370                 375 

Ala Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu Ser Leu Phe 
                380                 385                 390 

Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu Cys Leu Leu 
                395                 400                 405 

Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu Asp Ile Val 
                410                 415                 420 

Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile Leu Ser Pro 
                425                 430                 435 

Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala Ala Val 
                440                 445                 450 

Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile Lys 
                455                 460                 465 

Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys 
                470                 475                 480 

Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys 
                485                 490                 495 

Ser Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His 
                500                 505                 510 

Met Pro Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg 
                515                 520                 525 

Ile Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu 
                530                 535                 540 

Thr Thr Gly Arg Ser Ser Gln Pro Lys Glu Trp 
                545                 550     

<210>  73
<211>  437
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86IgV-41BBL-OX40

<400>  73
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
                95                  100                 105 

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                110                 115                 120 

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                125                 130                 135 

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                140                 145                 150 

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                155                 160                 165 

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                170                 175                 180 

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                185                 190                 195 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                200                 205                 210 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                215                 220                 225 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                230                 235                 240 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                245                 250                 255 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                260                 265                 270 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                275                 280                 285 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Ser Leu Asn Gly Gly 
                290                 295                 300 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                305                 310                 315 

Gly Gly Ser Gly Gly Gly Gly Ser Thr Ser Ala Pro Leu Lys Ile 
                320                 325                 330 

Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala 
                335                 340                 345 

Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln 
                350                 355                 360 

Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
                365                 370                 375 

Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe 
                380                 385                 390 

Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
                395                 400                 405 

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
                410                 415                 420 

Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
                425                 430                 435 

Ala Asn 
        

<210>  74
<211>  613
<212>  PRT
<213>  Homo sapiens

<220>
<223>  RANK WT

<400>  74
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Gly 
                200                 205                 210 

Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala Leu Val Ala Ala 
                215                 220                 225 

Ile Ile Phe Gly Val Cys Tyr Arg Lys Lys Gly Lys Ala Leu Thr 
                230                 235                 240 

Ala Asn Leu Trp His Trp Ile Asn Glu Ala Cys Gly Arg Leu Ser 
                245                 250                 255 

Gly Asp Lys Glu Ser Ser Gly Asp Ser Cys Val Ser Thr His Thr 
                260                 265                 270 

Ala Asn Phe Gly Gln Gln Gly Ala Cys Glu Gly Val Leu Leu Leu 
                275                 280                 285 

Thr Leu Glu Glu Lys Thr Phe Pro Glu Asp Met Cys Tyr Pro Asp 
                290                 295                 300 

Gln Gly Gly Val Cys Gln Gly Thr Cys Val Gly Gly Gly Pro Tyr 
                305                 310                 315 

Ala Gln Gly Glu Asp Ala Arg Met Leu Ser Leu Val Ser Lys Thr 
                320                 325                 330 

Glu Ile Glu Glu Asp Ser Phe Arg Gln Met Pro Thr Glu Asp Glu 
                335                 340                 345 

Tyr Met Asp Arg Pro Ser Gln Pro Thr Asp Gln Leu Leu Phe Leu 
                350                 355                 360 

Thr Glu Pro Gly Ser Lys Ser Thr Pro Pro Phe Ser Glu Pro Leu 
                365                 370                 375 

Glu Val Gly Glu Asn Asp Ser Leu Ser Gln Cys Phe Thr Gly Thr 
                380                 385                 390 

Gln Ser Thr Val Gly Ser Glu Ser Cys Asn Cys Thr Glu Pro Leu 
                395                 400                 405 

Cys Arg Thr Asp Trp Thr Pro Met Ser Ser Glu Asn Tyr Leu Gln 
                410                 415                 420 

Lys Glu Val Asp Ser Gly His Cys Pro His Trp Ala Ala Ser Pro 
                425                 430                 435 

Ser Pro Asn Trp Ala Asp Val Cys Thr Gly Cys Arg Asn Pro Pro 
                440                 445                 450 

Gly Glu Asp Cys Glu Pro Leu Val Gly Ser Pro Lys Arg Gly Pro 
                455                 460                 465 

Leu Pro Gln Cys Ala Tyr Gly Met Gly Leu Pro Pro Glu Glu Glu 
                470                 475                 480 

Ala Ser Arg Thr Glu Ala Arg Asp Gln Pro Glu Asp Gly Ala Asp 
                485                 490                 495 

Gly Arg Leu Pro Ser Ser Ala Arg Ala Gly Ala Gly Ser Gly Ser 
                500                 505                 510 

Ser Pro Gly Gly Gln Ser Pro Ala Ser Gly Asn Val Thr Gly Asn 
                515                 520                 525 

Ser Asn Ser Thr Phe Ile Ser Ser Gly Gln Val Met Asn Phe Lys 
                530                 535                 540 

Gly Asp Ile Ile Val Val Tyr Val Ser Gln Thr Ser Gln Glu Gly 
                545                 550                 555 

Ala Ala Ala Ala Ala Glu Pro Met Gly Arg Pro Val Gln Glu Glu 
                560                 565                 570 

Thr Leu Ala Arg Arg Asp Ser Phe Ala Gly Asn Gly Pro Arg Phe 
                575                 580                 585 

Pro Asp Pro Cys Gly Gly Pro Glu Gly Leu Arg Glu Pro Glu Lys 
                590                 595                 600 

Ala Ser Arg Pro Val Gln Glu Gln Gly Gly Ala Lys Ala 
                605                 610             

<210>  75
<211>  230
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANKmincyto

<400>  75
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Gly 
                200                 205                 210 

Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala Leu Val Ala Ala 
                215                 220                 225 

Ile Ile Phe Gly Val 
                230 

<210>  76
<211>  272
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-OX40

<400>  76
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Val 
                200                 205                 210 

Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
                215                 220                 225 

Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg 
                230                 235                 240 

Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg 
                245                 250                 255 

Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala 
                260                 265                 270 

Lys Ile 
        

<210>  77
<211>  278
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-41BB

<400>  77
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Ile 
                200                 205                 210 

Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
                215                 220                 225 

Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg 
                230                 235                 240 

Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                245                 250                 255 

Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                260                 265                 270 

Glu Glu Glu Gly Gly Cys Glu Leu 
                275             

<210>  78
<211>  452
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-IL18RAP

<400>  78
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Gly 
                200                 205                 210 

Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr Leu Val 
                215                 220                 225 

Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His Trp Ile Glu 
                230                 235                 240 

Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln Thr Leu 
                245                 250                 255 

Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys Trp 
                260                 265                 270 

Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His 
                275                 280                 285 

Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly 
                290                 295                 300 

Tyr Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val 
                305                 310                 315 

Tyr Ala Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly 
                320                 325                 330 

Ile Phe Ile Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe 
                335                 340                 345 

Glu Leu Gln Ala Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu 
                350                 355                 360 

Lys Leu Ile Leu Ile Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser 
                365                 370                 375 

Leu Pro His Leu Val Lys Lys Ala Leu Arg Val Leu Pro Thr Val 
                380                 385                 390 

Thr Trp Arg Gly Leu Lys Ser Val Pro Pro Asn Ser Arg Phe Trp 
                395                 400                 405 

Ala Lys Met Arg Tyr His Met Pro Val Lys Asn Ser Gln Gly Phe 
                410                 415                 420 

Thr Trp Asn Gln Leu Arg Ile Thr Ser Arg Ile Phe Gln Trp Lys 
                425                 430                 435 

Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg Ser Ser Gln Pro Lys 
                440                 445                 450 

Glu Trp 
        

<210>  79
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40WT mincyto

<400>  79
Met Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln Gly 
1               5                   10                  15  

Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
                20                  25                  30  

Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys 
                35                  40                  45  

Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr 
                50                  55                  60  

Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val 
                65                  70                  75  

Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr 
                80                  85                  90  

Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu 
                95                  100                 105 

Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu 
                110                 115                 120 

Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val 
                125                 130                 135 

Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly 
                140                 145                 150 

Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                155                 160                 165 




<210>  80
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD8-Q8

<400>  80
Met Gly Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Ile Pro 
1               5                   10                  15  

Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly 
                20                  25                  30  

Phe Met Ala Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
                35                  40                  45  

Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
                50                  55                  60  

Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                65                  70                  75  

Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                80                  85                  90  

Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                95                  100                 105 

Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                110                 115                 120 

Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
                125                 130                 135 

Pro Val Val 
            

<210>  81
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  eGFP

<400>  81
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
1               5                   10                  15  

Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
                20                  25                  30  

Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
                35                  40                  45  

Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
                50                  55                  60  

Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr 
                65                  70                  75  

Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
                80                  85                  90  

Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
                95                  100                 105 

Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
                110                 115                 120 

Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                125                 130                 135 

Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                140                 145                 150 

Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
                155                 160                 165 

Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
                170                 175                 180 

Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
                185                 190                 195 

Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
                200                 205                 210 

Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                215                 220                 225 

Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                230                 235                 

<210>  82
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD1 Fe11

<400>  82
Cys Ala Leu Gly Asp Ser Tyr Gly Gly Gly Pro Leu Tyr Thr Asp 
1               5                   10                  15  

Lys Leu Ile Phe 
                

<210>  83
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD2 cl3

<400>  83
Cys Ala Cys Asp Leu Leu Gly Tyr Thr Asp Lys Leu Ile Phe 
1               5                   10                  

<210>  84
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD2 cl5

<400>  84
Cys Ala Cys Asp Ala Leu Lys Arg Thr Asp Thr Asp Lys Leu Ile 
1               5                   10                  15  

Phe Gly 
        

<210>  85
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG5 Fe11

<400>  85
Cys Ala Thr Trp Asp Arg Pro Glu Ile Tyr Tyr Lys Lys Leu Phe 
1               5                   10                  15  




<210>  86
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG9 cl3

<400>  86
Cys Ala Leu Trp Glu Glu Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15  




<210>  87
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG9 cl5

<400>  87
Cys Ala Leu Trp Glu Ile Gln Glu Leu Gly Lys Lys Ile Lys Val 
1               5                   10                  15  

Phe 
    

<210>  88
<211>  135
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD cl3

<400>  88
Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala 
1               5                   10                  15  

Gly Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val 
                20                  25                  30  

Pro Val Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys 
                35                  40                  45  

Gly Glu Ala Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr 
                50                  55                  60  

Gln Gly Asn Thr Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr 
                65                  70                  75  

Gly Pro Gly Phe Lys Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala 
                80                  85                  90  

Lys Asn Leu Ala Val Leu Lys Ile Leu Ala Pro Ser Glu Arg Asp 
                95                  100                 105 

Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Leu Leu Gly Tyr Thr Asp 
                110                 115                 120 

Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg 
                125                 130                 135 




<210>  89
<211>  140
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG cl3

<400>  89
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala 
1               5                   10                  15  

Leu Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser 
                20                  25                  30  

Ser Thr Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val 
                35                  40                  45  

Ser Gly Ile Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu 
                50                  55                  60  

Arg Pro Gly Glu Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp 
                65                  70                  75  

Gly Thr Val Arg Lys Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu 
                80                  85                  90  

Val Asp Arg Ile Pro Glu Thr Ser Thr Ser Thr Leu Thr Ile His 
                95                  100                 105 

Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr Cys Ala Leu Trp 
                110                 115                 120 

Glu Glu Glu Leu Gly Lys Lys Ile Lys Val Phe Gly Pro Gly Thr 
                125                 130                 135 

Lys Leu Ile Ile Thr 
                140 

<210>  90
<211>  137
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD cl5

<400>  90
Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala 
1               5                   10                  15  

Gly Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val 
                20                  25                  30  

Pro Val Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys 
                35                  40                  45  

Gly Glu Ala Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr 
                50                  55                  60  

Gln Gly Asn Thr Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr 
                65                  70                  75  

Gly Pro Gly Phe Lys Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala 
                80                  85                  90  

Lys Asn Leu Ala Val Leu Lys Ile Leu Ala Pro Ser Glu Arg Asp 
                95                  100                 105 

Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Ala Leu Lys Arg Thr Asp 
                110                 115                 120 

Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val Glu 
                125                 130                 135 

Pro Arg 
        

<210>  91
<211>  141
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG cl5

<400>  91
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala 
1               5                   10                  15  

Leu Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser 
                20                  25                  30  

Ser Thr Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val 
                35                  40                  45  

Ser Gly Ile Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu 
                50                  55                  60  

Arg Pro Gly Glu Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp 
                65                  70                  75  

Gly Thr Val Arg Lys Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu 
                80                  85                  90  

Val Asp Arg Ile Pro Glu Thr Ser Thr Ser Thr Leu Thr Ile His 
                95                  100                 105 

Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr Cys Ala Leu Trp 
                110                 115                 120 

Glu Ile Gln Glu Leu Gly Lys Lys Ile Lys Val Phe Gly Pro Gly 
                125                 130                 135 

Thr Lys Leu Ile Ile Thr 
                140     

<210>  92
<211>  140
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD Fe11

<400>  92
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Asp Ser Tyr Gly Gly Gly 
                110                 115                 120 

Pro Leu Tyr Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val 
                125                 130                 135 

Thr Val Glu Pro Arg 
                140 

<210>  93
<211>  136
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG Fe11

<400>  93
Met Gly Trp Ala Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Gly Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Arg Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val 
                35                  40                  45  

Ile Asn Ala Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val Ser Asn Ser Lys Asp 
                65                  70                  75  

Val Leu Glu Ser Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr 
                80                  85                  90  

Pro Arg Arg Trp Ser Trp Ile Leu Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Arg Pro Glu 
                110                 115                 120 

Ile Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val 
                125                 130                 135 

Thr 
    

<210>  94
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG4 E113

<400>  94
Cys Ala Thr Trp Asp Gly Pro Pro Tyr Tyr Lys Lys Leu Phe 
1               5                   10                  

<210>  95
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG2 F4

<400>  95
Cys Ala Thr Trp Asp Gly Gln Lys Lys Leu Phe 
1               5                   10      

<210>  96
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG8 Zi11

<400>  96
Cys Ala Thr Trp Asp Asn Tyr Lys Lys Leu Phe 
1               5                   10      

<210>  97
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD5 D37

<400>  97
Cys Ala Ala Ser Ser Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys 
1               5                   10                  15  

Leu Ile Phe 
            

<210>  98
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD5 E113

<400>  98
Cys Ala Ala Ser Ser Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys 
1               5                   10                  15  

Leu Ile Phe 
            

<210>  99
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD1 F4

<400>  99
Cys Ala Leu Gly Glu Leu Arg Tyr Trp Gly Ile Val Asp Lys Leu 
1               5                   10                  15  

Ile Phe 
        

<210>  100
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD1 Zi11

<400>  100
Cys Ala Leu Gly Glu Leu Arg Gly Gln Ile Ser Phe Leu Tyr Leu 
1               5                   10                  15  

Leu Gly Asp Thr Thr Asp Lys Leu Ile Phe 
                20                  25  

<210>  101
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG4 E57

<400>  101
Cys Ala Thr Trp Asp Gly Phe Tyr Tyr Lys Lys Leu Phe 
1               5                   10              

<210>  102
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD5 E57

<400>  102
Cys Ala Ala Ser Ser Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys 
1               5                   10                  15  

Leu Ile Phe 
            

<210>  103
<211>  144
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD E113

<400>  103
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln 
1               5                   10                  15  

Pro Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val 
                20                  25                  30  

Lys Gln Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser 
                35                  40                  45  

Ile Leu Asn Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu 
                50                  55                  60  

Trp Tyr Lys Lys Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser 
                65                  70                  75  

Ile Ser Ser Ile Lys Asp Lys Asn Glu Asp Gly Arg Phe Thr Val 
                80                  85                  90  

Phe Leu Asn Lys Ser Ala Lys His Leu Ser Leu His Ile Val Pro 
                95                  100                 105 

Ser Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser Ser 
                110                 115                 120 

Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys Leu Ile Phe Gly Lys 
                125                 130                 135 

Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 

<210>  104
<211>  135
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG E113

<400>  104
Met Glu Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu 
                35                  40                  45  

Gly Ser Thr Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Thr Ser Ser Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Pro Gly Lys Tyr Asp Thr Tyr Gly 
                80                  85                  90  

Ser Thr Arg Lys Asn Leu Arg Met Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Pro Pro 
                110                 115                 120 

Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130                 135 




<210>  105
<211>  138
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD F4

<400>  105
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Glu Leu Arg Tyr Trp Gly 
                110                 115                 120 

Ile Val Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val 
                125                 130                 135 

Glu Pro Arg 
            

<210>  106
<211>  132
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG F4

<400>  106
Met Glu Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu 
                35                  40                  45  

Gly Ser Asn Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Gln Tyr Tyr Asp Ser Tyr Asn Ser Lys Val 
                65                  70                  75  

Val Leu Glu Ser Gly Val Ser Pro Gly Lys Tyr Tyr Thr Tyr Ala 
                80                  85                  90  

Ser Thr Arg Asn Asn Leu Arg Leu Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Gln Lys 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130         

<210>  107
<211>  146
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD Zi11

<400>  107
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Glu Leu Arg Gly Gln Ile 
                110                 115                 120 

Ser Phe Leu Tyr Leu Leu Gly Asp Thr Thr Asp Lys Leu Ile Phe 
                125                 130                 135 

Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 145     

<210>  108
<211>  132
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG Zi11

<400>  108
Met Val Leu Ala Leu Ala Leu Leu Leu Ala Phe Leu Pro Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Gly Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val 
                35                  40                  45  

Glu Asn Ala Val Tyr Thr His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala 
                80                  85                  90  

Ser Thr Gly Lys Ser Leu Lys Phe Ile Leu Glu Asn Leu Ile Glu 
                95                  100                 105 

Arg Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Asn Tyr Lys 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130         

<210>  109
<211>  144
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD D37

<400>  109
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln 
1               5                   10                  15  

Pro Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val 
                20                  25                  30  

Lys Gln Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser 
                35                  40                  45  

Ile Leu Asn Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu 
                50                  55                  60  

Trp Tyr Lys Lys Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser 
                65                  70                  75  

Ile Ser Ser Ile Lys Asp Lys Asn Glu Asp Gly Arg Phe Thr Val 
                80                  85                  90  

Phe Leu Asn Lys Ser Ala Lys His Leu Ser Leu His Ile Val Pro 
                95                  100                 105 

Ser Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser Ser 
                110                 115                 120 

Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys Leu Ile Phe Gly Lys 
                125                 130                 135 

Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 

<210>  110
<211>  132
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG D37

<400>  110
Met Val Leu Ala Leu Ala Leu Leu Leu Ala Phe Leu Pro Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Gly Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val 
                35                  40                  45  

Glu Asn Ala Val Tyr Thr His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala 
                80                  85                  90  

Ser Thr Gly Lys Ser Leu Lys Phe Ile Leu Glu Asn Leu Ile Glu 
                95                  100                 105 

Arg Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Asn Tyr Met 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130         

<210>  111
<211>  144
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD E57

<400>  111
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln 
1               5                   10                  15  

Pro Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val 
                20                  25                  30  

Lys Gln Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser 
                35                  40                  45  

Ile Leu Asn Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu 
                50                  55                  60  

Trp Tyr Lys Lys Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser 
                65                  70                  75  

Ile Ser Ser Ile Lys Asp Lys Asn Glu Asp Gly Arg Phe Thr Val 
                80                  85                  90  

Phe Leu Asn Lys Ser Ala Lys His Leu Ser Leu His Ile Val Pro 
                95                  100                 105 

Ser Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser Ser 
                110                 115                 120 

Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys Leu Ile Phe Gly Lys 
                125                 130                 135 

Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 

<210>  112
<211>  134
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG E57

<400>  112
Met Glu Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu 
                35                  40                  45  

Gly Ser Thr Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Thr Ser Ser Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Pro Gly Lys Tyr Asp Thr Tyr Gly 
                80                  85                  90  

Ser Thr Arg Lys Asn Leu Arg Met Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Phe Tyr 
                110                 115                 120 

Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130                 

<210>  113
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG8 D37

<400>  113
Cys Ala Thr Trp Asp Asn Tyr Met Lys Leu Phe 
1               5                   10      

<210>  114
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD3 F2

<400>  114
Cys Ala Ser Ser Tyr Thr Leu Lys Leu Gly Asp Thr Pro Gly Arg 
1               5                   10                  15  

Val Arg Asp Trp Lys Leu Ile Phe 
                20              

<210>  115
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG4 F2

<400>  115
Cys Ala Thr Trp Asp Gly Pro Pro Tyr Tyr Lys Lys Leu Phe 
1               5                   10                  

<210>  116
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD1 Ze11

<400>  116
Cys Ala Leu Gly Asp Tyr Leu Gly Asp Lys Tyr Pro Ser Tyr Asp 
1               5                   10                  15  

Leu Leu Gly Asp Thr Thr Asp Lys Leu Ile Phe 
                20                  25      

<210>  117
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG8 Ze11

<400>  117
Cys Ala Thr Trp Asp Asn Tyr Lys Lys Leu Phe 
1               5                   10      

<210>  118
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD5 B23

<400>  118
Cys Ala Ala Ser Ser Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys 
1               5                   10                  15  

Leu Ile Phe 
            

<210>  119
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG8 B23

<400>  119
Cys Ala Thr Trp Asp Asn Tyr Lys Lys Leu Phe 
1               5                   10      

<210>  120
<211>  144
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD F2

<400>  120
Met Ile Leu Thr Val Gly Phe Ser Phe Leu Phe Phe Tyr Arg Gly 
1               5                   10                  15  

Thr Leu Cys Asp Lys Val Thr Gln Ser Ser Pro Asp Gln Thr Val 
                20                  25                  30  

Ala Ser Gly Ser Glu Val Val Leu Leu Cys Thr Tyr Asp Thr Val 
                35                  40                  45  

Tyr Ser Asn Pro Asp Leu Phe Trp Tyr Arg Ile Arg Pro Asp Tyr 
                50                  55                  60  

Ser Phe Gln Phe Val Phe Tyr Gly Asp Asn Ser Arg Ser Glu Gly 
                65                  70                  75  

Ala Asp Phe Thr Gln Gly Arg Phe Ser Val Lys His Ile Leu Thr 
                80                  85                  90  

Gln Lys Ala Phe His Leu Val Ile Ser Pro Val Arg Thr Glu Asp 
                95                  100                 105 

Ser Ala Thr Tyr Tyr Cys Ala Ser Ser Tyr Thr Leu Lys Leu Gly 
                110                 115                 120 

Asp Thr Pro Gly Arg Val Arg Asp Trp Lys Leu Ile Phe Gly Lys 
                125                 130                 135 

Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 

<210>  121
<211>  135
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG F2

<400>  121
Met Glu Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu 
                35                  40                  45  

Gly Ser Thr Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Thr Ser Ser Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Pro Gly Lys Tyr Asp Thr Tyr Gly 
                80                  85                  90  

Ser Thr Arg Lys Asn Leu Arg Met Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Pro Pro 
                110                 115                 120 

Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130                 135 




<210>  122
<211>  147
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD Ze11

<400>  122
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Asp Tyr Leu Gly Asp Lys 
                110                 115                 120 

Tyr Pro Ser Tyr Asp Leu Leu Gly Asp Thr Thr Asp Lys Leu Ile 
                125                 130                 135 

Phe Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 145         

<210>  123
<211>  132
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG Ze11

<400>  123
Met Val Leu Ala Leu Ala Leu Leu Leu Ala Phe Leu Pro Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Gly Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val 
                35                  40                  45  

Glu Asn Ala Val Tyr Thr His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala 
                80                  85                  90  

Ser Thr Gly Lys Ser Leu Lys Phe Ile Leu Glu Asn Leu Ile Glu 
                95                  100                 105 

Arg Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Asn Tyr Lys 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130         

<210>  124
<211>  144
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD B23

<400>  124
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln 
1               5                   10                  15  

Pro Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val 
                20                  25                  30  

Lys Gln Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser 
                35                  40                  45  

Ile Leu Asn Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu 
                50                  55                  60  

Trp Tyr Lys Lys Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser 
                65                  70                  75  

Ile Ser Ser Ile Lys Asp Lys Asn Glu Asp Gly Arg Phe Thr Val 
                80                  85                  90  

Phe Leu Asn Lys Ser Ala Lys His Leu Ser Leu His Ile Val Pro 
                95                  100                 105 

Ser Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser Ser 
                110                 115                 120 

Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys Leu Ile Phe Gly Lys 
                125                 130                 135 

Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 

<210>  125
<211>  132
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG B23

<400>  125
Met Val Leu Ala Leu Ala Leu Leu Leu Ala Phe Leu Pro Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Gly Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val 
                35                  40                  45  

Glu Asn Ala Val Tyr Thr His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala 
                80                  85                  90  

Ser Thr Gly Lys Ser Leu Lys Phe Ile Leu Glu Asn Leu Ile Glu 
                95                  100                 105 

Arg Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Asn Tyr Lys 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130         

<210>  126
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD1 B9

<400>  126
Cys Ala Leu Gly Asn Gly Asn His Ile Gly Tyr Trp Arg Tyr Thr 
1               5                   10                  15  

Asp Lys Leu Ile Phe 
                20  

<210>  127
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG5  B9

<400>  127
Cys Ala Thr Trp Asp Arg Leu Tyr Tyr Lys Lys Leu Phe 
1               5                   10              

<210>  128
<211>  141
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD B9

<400>  128
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Asn Gly Asn His Ile Gly 
                110                 115                 120 

Tyr Trp Arg Tyr Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg 
                125                 130                 135 

Val Thr Val Glu Pro Arg 
                140     

<210>  129
<211>  134
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG B9

<400>  129
Met Val Trp Ala Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Gly Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Arg Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val 
                35                  40                  45  

Ile Asn Ala Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val Ser Asn Ser Lys Asp 
                65                  70                  75  

Val Leu Glu Ser Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr 
                80                  85                  90  

Pro Arg Arg Trp Ser Trp Ile Leu Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Arg Leu Tyr 
                110                 115                 120 

Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130                 

<210>  130
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG8 An2

<400>  130
Cys Ala Thr Trp Asp Ser Ser Lys Leu Phe 
1               5                   10  

<210>  131
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD3 An2

<400>  131
Cys Ala Phe Thr Gly Leu Gly Asp Thr Ser His Ala Asp Lys Leu 
1               5                   10                  15  

Ile Phe 
        

<210>  132
<211>  131
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG An2

<400>  132
Met Leu Leu Ala Leu Ala Leu Leu Leu Ala Phe Leu Pro Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Gly Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val 
                35                  40                  45  

Glu Asn Ala Val Tyr Thr His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala 
                80                  85                  90  

Ser Thr Gly Lys Ser Leu Lys Phe Ile Leu Glu Asn Leu Ile Glu 
                95                  100                 105 

Arg Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Ser Ser Lys 
                110                 115                 120 

Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130     

<210>  133
<211>  138
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD An2

<400>  133
Met Ile Leu Thr Val Gly Phe Ser Phe Leu Phe Phe Tyr Arg Gly 
1               5                   10                  15  

Thr Leu Cys Asp Lys Val Thr Gln Ser Ser Pro Asp Gln Thr Val 
                20                  25                  30  

Ala Ser Gly Ser Glu Val Val Leu Leu Cys Thr Tyr Asp Thr Val 
                35                  40                  45  

Tyr Ser Asn Pro Asp Leu Phe Trp Tyr Arg Ile Arg Pro Asp Tyr 
                50                  55                  60  

Ser Phe Gln Phe Val Phe Tyr Gly Asp Asn Ser Arg Ser Glu Gly 
                65                  70                  75  

Ala Asp Phe Thr Gln Gly Arg Phe Ser Val Lys His Ile Leu Thr 
                80                  85                  90  

Gln Lys Ala Phe His Leu Val Ile Ser Pro Val Arg Thr Glu Asp 
                95                  100                 105 

Ser Ala Thr Tyr Tyr Cys Ala Phe Thr Gly Leu Gly Asp Thr Ser 
                110                 115                 120 

His Ala Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val 
                125                 130                 135 

Glu Pro Arg 
            

<210>  134
<211>  153
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRDC

<400>  134
Ser Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly 
1               5                   10                  15  

Thr Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile 
                20                  25                  30  

Arg Ile Asn Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro 
                35                  40                  45  

Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu 
                50                  55                  60  

Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser Val Gln His 
                65                  70                  75  

Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val Lys Thr Asp 
                80                  85                  90  

Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln 
                95                  100                 105 

Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
                110                 115                 120 

Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu 
                125                 130                 135 

Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu 
                140                 145                 150 

Phe Phe Leu 
            

<210>  135
<211>  173
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRGC1

<400>  135
Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe 
1               5                   10                  15  

Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr 
                20                  25                  30  

Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His 
                35                  40                  45  

Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly 
                50                  55                  60  

Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu 
                65                  70                  75  

Thr Val Pro Glu Lys Ser Leu Asp Lys Glu His Arg Cys Ile Val 
                80                  85                  90  

Arg His Glu Asn Asn Lys Asn Gly Val Asp Gln Glu Ile Ile Phe 
                95                  100                 105 

Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn 
                110                 115                 120 

Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn 
                125                 130                 135 

Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val 
                140                 145                 150 

Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala 
                155                 160                 165 

Phe Cys Cys Asn Gly Glu Lys Ser 
                170             

<210>  136
<211>  189
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRGC2

<400>  136
Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe 
1               5                   10                  15  

Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr 
                20                  25                  30  

Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His 
                35                  40                  45  

Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly 
                50                  55                  60  

Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu 
                65                  70                  75  

Thr Val Pro Glu Glu Ser Leu Asp Lys Glu His Arg Cys Ile Val 
                80                  85                  90  

Arg His Glu Asn Asn Lys Asn Gly Ile Asp Gln Glu Ile Ile Phe 
                95                  100                 105 

Pro Pro Ile Lys Thr Asp Val Thr Thr Val Asp Pro Lys Tyr Asn 
                110                 115                 120 

Tyr Ser Lys Asp Ala Asn Asp Val Ile Thr Met Asp Pro Lys Asp 
                125                 130                 135 

Asn Trp Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr 
                140                 145                 150 

Asn Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu Lys Ser 
                155                 160                 165 

Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr 
                170                 175                 180 

Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                185                 

<210>  137
<211>  319
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ICOSL -41BB

<400>  137
Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser 
1               5                   10                  15  

Leu Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly 
                20                  25                  30  

Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe 
                35                  40                  45  

Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys 
                50                  55                  60  

Thr Val Val Thr Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn 
                65                  70                  75  

Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly 
                80                  85                  90  

Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
                95                  100                 105 

Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Gln Ser Leu 
                110                 115                 120 

Gly Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala 
                125                 130                 135 

Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro His Ser Pro Ser 
                140                 145                 150 

Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn Gly Tyr Pro 
                155                 160                 165 

Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser Leu Leu 
                170                 175                 180 

Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg Gly 
                185                 190                 195 

Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
                200                 205                 210 

Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn 
                215                 220                 225 

Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
                230                 235                 240 

Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala 
                245                 250                 255 

Thr Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala 
                260                 265                 270 

Val Ala Ile Gly Trp Val Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                275                 280                 285 

Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                290                 295                 300 

Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                305                 310                 315 

Gly Cys Glu Leu 
                

<210>  138
<211>  277
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ICOSL extra + tm

<400>  138
Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser 
1               5                   10                  15  

Leu Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly 
                20                  25                  30  

Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe 
                35                  40                  45  

Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys 
                50                  55                  60  

Thr Val Val Thr Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn 
                65                  70                  75  

Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly 
                80                  85                  90  

Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
                95                  100                 105 

Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Gln Ser Leu 
                110                 115                 120 

Gly Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala 
                125                 130                 135 

Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro His Ser Pro Ser 
                140                 145                 150 

Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn Gly Tyr Pro 
                155                 160                 165 

Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser Leu Leu 
                170                 175                 180 

Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg Gly 
                185                 190                 195 

Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
                200                 205                 210 

Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn 
                215                 220                 225 

Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
                230                 235                 240 

Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala 
                245                 250                 255 

Thr Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala 
                260                 265                 270 

Val Ala Ile Gly Trp Val Cys 
                275         

<210>  139
<211>  256
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ICOSL extra

<400>  139
Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser 
1               5                   10                  15  

Leu Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly 
                20                  25                  30  

Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe 
                35                  40                  45  

Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys 
                50                  55                  60  

Thr Val Val Thr Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn 
                65                  70                  75  

Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly 
                80                  85                  90  

Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
                95                  100                 105 

Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Gln Ser Leu 
                110                 115                 120 

Gly Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala 
                125                 130                 135 

Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro His Ser Pro Ser 
                140                 145                 150 

Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn Gly Tyr Pro 
                155                 160                 165 

Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser Leu Leu 
                170                 175                 180 

Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg Gly 
                185                 190                 195 

Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
                200                 205                 210 

Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn 
                215                 220                 225 

Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
                230                 235                 240 

Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala 
                245                 250                 255 

Thr 
    

<210>  140
<211>  885
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 45 (41BBL-OX40)

<400>  140
atgctggggc gcgaccagag gctgccacct gacgcacaca agccacctgg                 50
tgggggctca tttcgaactc ccatccagga agagcaggcc gacgcacaca                 100
gtacccttgc caaaatcact agtggaagtt atgccagtga cgcatctctc                 150
gatcccgaag ccccttggcc accggcgcca agagctagag cttgcagagt                 200
gttgccttgg gctttggtgg ccggactgct gctcctgctg ctgctggctg                 250
ctgcctgtgc cgtgtttctc gcatgtcctt gggctgtgtc cggtgcaaga                 300
gcctctcctg gatctgccgc gagtccgcgc ctgcgagagg gaccagaatt                 350
gtcaccggat gaccctgcag gccttctcga tctcaggcaa ggaatgtttg                 400
cgcagctggt ggcacaaaac gtgttgctta tagacggacc acttagctgg                 450
tattctgatc ccggcctggc cggggtttca ttgaccggcg gcctttccta                 500
caaggaagat accaaggaac tggtggtcgc caaggccgga gtatactatg                 550
ttttcttcca attggagttg cggcgcgtcg tggcagggga agggagcggt                 600
tctgtctctt tggctctcca cctgcaaccc ttgagatccg cggctggagc                 650
tgcagctttg gcgctcactg ttgacctgcc acctgcaagt tccgaggctc                 700
ggaactcagc gttcgggttt caaggcagac tgctgcacct gagcgccggg                 750
caaagacttg gtgtacactt gcacactgag gctagagccc gccacgcttg                 800
gcaactcaca caaggggcta cagtgcttgg cctgttccga gtaacgcccg                 850
aaattccagc gggcctgcca agtcctagat ctgaa                                 885

<210>  141
<211>  843
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 46 (41BBL13W-OX40rev)

<400>  141
atggaaatca aggctctaac cagccacgcg gacgctcagg aagaacaaat                 50
tcccacccgc tttagtggtg gggggccacc taaacatgct gatcctccat                 100
tgcgacagga taggaggctg ctgtggccac cggcgccaag agctagagct                 150
tgcagagtgt tgccttgggc tttggtggcc ggactgctgc tcctgctgct                 200
gctggctgct gcctgtgccg tgtttctcgc atgtccttgg gctgtgtccg                 250
gtgcaagagc ctctcctgga tctgccgcga gtccgcgcct gcgagaggga                 300
ccagaattgt caccggatga ccctgcaggc cttctcgatc tcaggcaagg                 350
aatgtttgcg cagctggtgg cacaaaacgt gttgcttata gacggaccac                 400
ttagctggta ttctgatccc ggcctggccg gggtttcatt gaccggcggc                 450
ctttcctaca aggaagatac caaggaactg gtggtcgcca aggccggagt                 500
atactatgtt ttcttccaat tggagttgcg gcgcgtcgtg gcaggggaag                 550
ggagcggttc tgtctctttg gctctccacc tgcaaccctt gagatccgcg                 600
gctggagctg cagctttggc gctcactgtt gacctgccac ctgcaagttc                 650
cgaggctcgg aactcagcgt tcgggtttca aggcagactg ctgcacctga                 700
gcgccgggca aagacttggt gtacacttgc acactgaggc tagagcccgc                 750
cacgcttggc aactcacaca aggggctaca gtgcttggcc tgttccgagt                 800
aacgcccgaa attccagcgg gcctgccaag tcctagatct gaa                        843

<210>  142
<211>  864
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 47 (41BBL-NKp80)

<400>  142
atgcaggacg aggacgggta tatgactctc aacgttcaga gcaagaagag                 50
gtcttccgct cagacgagtc agctgacctt taaagactat agcgttacac                 100
tccattggta tgccagtgac gcatctctcg atcccgaagc cccttggcca                 150
ccggcgccaa gagctagagc ttgcagagtg ttgccttggg ctttggtggc                 200
cggactgctg ctcctgctgc tgctggctgc tgcctgtgcc gtgtttctcg                 250
catgtccttg ggctgtgtcc ggtgcaagag cctctcctgg atctgccgcg                 300
agtccgcgcc tgcgagaggg accagaattg tcaccggatg accctgcagg                 350
ccttctcgat ctcaggcaag gaatgtttgc gcagctggtg gcacaaaacg                 400
tgttgcttat agacggacca cttagctggt attctgatcc cggcctggcc                 450
ggggtttcat tgaccggcgg cctttcctac aaggaagata ccaaggaact                 500
ggtggtcgcc aaggccggag tatactatgt tttcttccaa ttggagttgc                 550
ggcgcgtcgt ggcaggggaa gggagcggtt ctgtctcttt ggctctccac                 600
ctgcaaccct tgagatccgc ggctggagct gcagctttgg cgctcactgt                 650
tgacctgcca cctgcaagtt ccgaggctcg gaactcagcg ttcgggtttc                 700
aaggcagact gctgcacctg agcgccgggc aaagacttgg tgtacacttg                 750
cacactgagg ctagagcccg ccacgcttgg caactcacac aaggggctac                 800
agtgcttggc ctgttccgag taacgcccga aattccagcg ggcctgccaa                 850
gtcctagatc tgaa                                                        864

<210>  143
<211>  792
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 48 (41BBLmincyto-NKp80)

<400>  143
atgcaggacg aggacgggta tatgactctc aacgttcaga gcaagaagag                 50
gtcttccgct cagacgagtc agctgacctt taaagactat agcgttacac                 100
tccattggta caaatgggct ttggtggccg gactgctgct cctgctgctg                 150
ctggctgctg cctgtgccgt gtttctcgca tgtccttggg ctgtgtccgg                 200
tgcaagagcc tctcctggat ctgccgcgag tccgcgcctg cgagagggac                 250
cagaattgtc accggatgac cctgcaggcc ttctcgatct caggcaagga                 300
atgtttgcgc agctggtggc acaaaacgtg ttgcttatag acggaccact                 350
tagctggtat tctgatcccg gcctggccgg ggtttcattg accggcggcc                 400
tttcctacaa ggaagatacc aaggaactgg tggtcgccaa ggccggagta                 450
tactatgttt tcttccaatt ggagttgcgg cgcgtcgtgg caggggaagg                 500
gagcggttct gtctctttgg ctctccacct gcaacccttg agatccgcgg                 550
ctggagctgc agctttggcg ctcactgttg acctgccacc tgcaagttcc                 600
gaggctcgga actcagcgtt cgggtttcaa ggcagactgc tgcacctgag                 650
cgccgggcaa agacttggtg tacacttgca cactgaggct agagcccgcc                 700
acgcttggca actcacacaa ggggctacag tgcttggcct gttccgagta                 750
acgcccgaaa ttccagcggg cctgccaagt cctagatctg aa                         792

<210>  144
<211>  693
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 50 (OX40L-41BB)

<400>  144
atgctgggga agcggggcag aaagaaactg ctgtacatct ttaagcagcc                 50
cttcatgcgg cccgtgcaga ccacccagga agaggacggc tgctcctgca                 100
gattccccga ggaagaagaa ggcggctgcg agctgggagg cagcgctgag                 150
cgtgttcagc cactggagga aaatgtcggc aacgccgcca ggcctcgatt                 200
cgagcgtaac aaactgctcc ttgttgctag tgtgattcag gggctgggac                 250
tgttgttgtg cttcacatac atttgtctcc acttttctgc attgcaggtc                 300
agccataggt atccccgcat tcagtctatc aaagtgcaat tcactgagta                 350
caagaaggag aaaggcttta ttttaactag tcaaaaggaa gacgagataa                 400
tgaaggtgca gaacaacagc gttattatca attgcgacgg gttctattta                 450
atctctctga aagggtactt ctcacaggag gttaacatta gtttacatta                 500
tcaaaaggac gaggaaccct tgttccagct gaaaaaagtg cggtctgtta                 550
attcccttat ggtggcgagt cttacataca aggacaaggt gtatctcaac                 600
gtgacaacgg acaatacctc tctggacgat tttcacgtta acggcgggga                 650
gcttatactt atccatcaaa acccaggaga attttgcgtc ctt                        693

<210>  145
<211>  696
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 51 (OX40L-41BBrev)

<400>  145
atgctggggc tggagtgcgg cggcgaggag gaggagccct tcaggtgcag                 50
ctgcggcgac gaggagcaga ccacccaggt gcccaggatg ttcccccaga                 100
agttcatcta cctgctgaag aagaggggca ggaagctggg aggcagcgct                 150
gagcgtgttc agccactgga ggaaaatgtc ggcaacgccg ccaggcctcg                 200
attcgagcgt aacaaactgc tccttgttgc tagtgtgatt caggggctgg                 250
gactgttgtt gtgcttcaca tacatttgtc tccacttttc tgcattgcag                 300
gtcagccata ggtatccccg cattcagtct atcaaagtgc aattcactga                 350
gtacaagaag gagaaaggct ttattttaac tagtcaaaag gaagacgaga                 400
taatgaaggt gcagaacaac agcgttatta tcaattgcga cgggttctat                 450
ttaatctctc tgaaagggta cttctcacag gaggttaaca ttagtttaca                 500
ttatcaaaag gacgaggaac ccttgttcca gctgaaaaaa gtgcggtctg                 550
ttaattccct tatggtggcg agtcttacat acaaggacaa ggtgtatctc                 600
aacgtgacaa cggacaatac ctctctggac gattttcacg ttaacggcgg                 650
ggagcttata cttatccatc aaaacccagg agaattttgc gtcctt                     696

<210>  146
<211>  1104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 52 (CD86-OX40)

<400>  146
atggaccctc agtgtaccat gggcctgagc aacatcctgt tcgtgatggc                 50
ctttctgctg agcggagccg ctcctctgaa gatccaggcc tacttcaacg                 100
agacagccga cctgccttgc cagttcgcca acagccagaa tcagagcctg                 150
agcgagctgg tggtgttctg gcaggaccaa gagaacctgg tgctgaacga                 200
ggtgtacctg ggcaaagaaa agttcgacag cgtgcacagc aagtacatgg                 250
gcagaaccag cttcgactcc gacagctgga cactgagact gcacaacctg                 300
cagatcaagg acaagggcct gtaccagtgc atcatccacc acaagaaacc                 350
caccggcatg atcagaatcc accagatgaa cagcgagctg agcgtgctgg                 400
ccaacttcag ccagcctgag atcgtgccca tcagcaacat caccgagaac                 450
gtgtacatca acctgacctg cagcagcatc cacggctacc ccgagcctaa                 500
gaaaatgtcc gtgctgctgc ggaccaagaa cagcaccatc gagtacgacg                 550
gcgtgatgca gaaaagccag gacaacgtga ccgagctgta cgacgtgtcc                 600
atcagcctgt ccgtgtcatt ccccgacgtg accagcaata tgaccatctt                 650
ctgcatcctg gaaaccgaca agacccggct gctgtctagc cccttcagca                 700
tagagctgga agatccccag cctcctcctg atcacatccc ttggattacc                 750
gccgtgctgc ccaccgtgat catctgcgtg atggtgtttt gcctgatcct                 800
gtggaagtgg aagaagaaga aacggcctcg gaacagctac aagtgcggca                 850
ccaacaccat ggaacgggaa gagagcgagc agaccaagaa gagagagaag                 900
attcacatcc ccgagcggag cgacgaagcc cagagagtgt ttaagagcag                 950
caagaccagc agctgcgaca agagcgatac ctgcttcgga tcagggcggg                 1000
atcagcgcct gcctccagat gcacataaac cccccggcgg cgggtctttt                 1050
agaacaccaa tacaagagga acaagctgac gcccacagta ccctcgcaaa                 1100
aatt                                                                   1104

<210>  147
<211>  939
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 53 (CD86delP276-OX40)

<400>  147
atggaccctc agtgtaccat gggcctgagc aacatcctgt tcgtgatggc                 50
ctttctgctg agcggagccg ctcctctgaa gatccaggcc tacttcaacg                 100
agacagccga cctgccttgc cagttcgcca acagccagaa tcagagcctg                 150
agcgagctgg tggtgttctg gcaggaccaa gagaacctgg tgctgaacga                 200
ggtgtacctg ggcaaagaaa agttcgacag cgtgcacagc aagtacatgg                 250
gcagaaccag cttcgactcc gacagctgga cactgagact gcacaacctg                 300
cagatcaagg acaagggcct gtaccagtgc atcatccacc acaagaaacc                 350
caccggcatg atcagaatcc accagatgaa cagcgagctg agcgtgctgg                 400
ccaacttcag ccagcctgag atcgtgccca tcagcaacat caccgagaac                 450
gtgtacatca acctgacctg cagcagcatc cacggctacc ccgagcctaa                 500
gaaaatgtcc gtgctgctgc ggaccaagaa cagcaccatc gagtacgacg                 550
gcgtgatgca gaaaagccag gacaacgtga ccgagctgta cgacgtgtcc                 600
atcagcctgt ccgtgtcatt ccccgacgtg accagcaata tgaccatctt                 650
ctgcatcctg gaaaccgaca agacccggct gctgtctagc cccttcagca                 700
tagagctgga agatccccag cctcctcctg atcacatccc ttggattacc                 750
gccgtgctgc ccaccgtgat catctgcgtg atggtgtttt gcctgatcct                 800
gtggaagtgg aagaagaaga aacggcctgg gcgggatcag cgcctgcctc                 850
cagatgcaca taaacccccc ggcggcgggt cttttagaac accaatacaa                 900
gaggaacaag ctgacgccca cagtaccctc gcaaaaatt                             939

<210>  148
<211>  762
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Sequence encoding SEQ ID NO: 54 (41BBL)

<400>  148
atggaatatg ccagtgacgc atctctcgat cccgaagccc cttggccacc                 50
ggcgccaaga gctagagctt gcagagtgtt gccttgggct ttggtggccg                 100
gactgctgct cctgctgctg ctggctgctg cctgtgccgt gtttctcgca                 150
tgtccttggg ctgtgtccgg tgcaagagcc tctcctggat ctgccgcgag                 200
tccgcgcctg cgagagggac cagaattgtc accggatgac cctgcaggcc                 250
ttctcgatct caggcaagga atgtttgcgc agctggtggc acaaaacgtg                 300
ttgcttatag acggaccact tagctggtat tctgatcccg gcctggccgg                 350
ggtttcattg accggcggcc tttcctacaa ggaagatacc aaggaactgg                 400
tggtcgccaa ggccggagta tactatgttt tcttccaatt ggagttgcgg                 450
cgcgtcgtgg caggggaagg gagcggttct gtctctttgg ctctccacct                 500
gcaacccttg agatccgcgg ctggagctgc agctttggcg ctcactgttg                 550
acctgccacc tgcaagttcc gaggctcgga actcagcgtt cgggtttcaa                 600
ggcagactgc tgcacctgag cgccgggcaa agacttggtg tacacttgca                 650
cactgaggct agagcccgcc acgcttggca actcacacaa ggggctacag                 700
tgcttggcct gttccgagta acgcccgaaa ttccagcggg cctgccaagt                 750
cctagatctg aa                                                          762

<210>  149
<211>  699
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 55 (41BBLmincyto)

<400>  149
atgtcaaaga gcacgggcag ctgggctttg gtggccggac tgctgctcct                 50
gctgctgctg gctgctgcct gtgccgtgtt tctcgcatgt ccttgggctg                 100
tgtccggtgc aagagcctct cctggatctg ccgcgagtcc gcgcctgcga                 150
gagggaccag aattgtcacc ggatgaccct gcaggccttc tcgatctcag                 200
gcaaggaatg tttgcgcagc tggtggcaca aaacgtgttg cttatagacg                 250
gaccacttag ctggtattct gatcccggcc tggccggggt ttcattgacc                 300
ggcggccttt cctacaagga agataccaag gaactggtgg tcgccaaggc                 350
cggagtatac tatgttttct tccaattgga gttgcggcgc gtcgtggcag                 400
gggaagggag cggttctgtc tctttggctc tccacctgca acccttgaga                 450
tccgcggctg gagctgcagc tttggcgctc actgttgacc tgccacctgc                 500
aagttccgag gctcggaact cagcgttcgg gtttcaaggc agactgctgc                 550
acctgagcgc cgggcaaaga cttggtgtac acttgcacac tgaggctaga                 600
gcccgccacg cttggcaact cacacaaggg gctacagtgc ttggcctgtt                 650
ccgagtaacg cccgaaattc cagcgggcct gccaagtcct agatctgaa                  699

<210>  150
<211>  885
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 57 (41BBL-OX40rev)

<400>  150
atgctgggga tcaaggctct aaccagccac gcggacgctc aggaagaaca                 50
aattcccacc cgctttagtg gtggggggcc acctaaacat gctgatcctc                 100
cattgcgaca ggataggact agtggaagtt atgccagtga cgcatctctc                 150
gatcccgaag ccccttggcc accggcgcca agagctagag cttgcagagt                 200
gttgccttgg gctttggtgg ccggactgct gctcctgctg ctgctggctg                 250
ctgcctgtgc cgtgtttctc gcatgtcctt gggctgtgtc cggtgcaaga                 300
gcctctcctg gatctgccgc gagtccgcgc ctgcgagagg gaccagaatt                 350
gtcaccggat gaccctgcag gccttctcga tctcaggcaa ggaatgtttg                 400
cgcagctggt ggcacaaaac gtgttgctta tagacggacc acttagctgg                 450
tattctgatc ccggcctggc cggggtttca ttgaccggcg gcctttccta                 500
caaggaagat accaaggaac tggtggtcgc caaggccgga gtatactatg                 550
ttttcttcca attggagttg cggcgcgtcg tggcagggga agggagcggt                 600
tctgtctctt tggctctcca cctgcaaccc ttgagatccg cggctggagc                 650
tgcagctttg gcgctcactg ttgacctgcc acctgcaagt tccgaggctc                 700
ggaactcagc gttcgggttt caaggcagac tgctgcacct gagcgccggg                 750
caaagacttg gtgtacactt gcacactgag gctagagccc gccacgcttg                 800
gcaactcaca caaggggcta cagtgcttgg cctgttccga gtaacgcccg                 850
aaattccagc gggcctgcca agtcctagat ctgaa                                 885

<210>  151
<211>  849
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 58 (41BBL-rev extra-OX40tm-cyto)

<400>  151
atgctgctgt tggtcacctc cttgttactc tgcgagcttc cacatcccgc                 50
tttcctctta attcccgacc agggcatgtt tgcgcagctc gtcgcccaga                 100
atgtcctcct aatagatggc ccactatcct ggtacagtga tccaggcctg                 150
gccggggtgt ctcttacggg aggcctgagc tataaggaag acaccaaaga                 200
gttggtggtc gcgaaggccg gagtgtatta tgtttttttt caacttgagc                 250
tgcgacgtgt ggtcgccgga gaaggctcgg gatctgtttc actcgctctt                 300
cacctgcaac cactgcggtc cgccgcgggg gctgccgctc tcgccctaac                 350
cgtggatctg cctcccgcct cttccgaagc acgcaattct gcttttggat                 400
ttcagggtag gctactgcat ctgtccgcag gccaacggtt aggtgtgcat                 450
ctgcatacag aagcccgggc tcggcacgcc tggcaactaa cacagggagc                 500
taccgtgctg ggtctgttta gagtgacacc tgaaatccct gccgggttac                 550
caagccctag gtccgagcgc ttggacctgc tgggagcacc agatgatcct                 600
agcttggagc ccggggagag acttcgccca agtgccgcta gcggcccctc                 650
tgctagggct gttgctgcca tcctaggact gggtcttgtt ctcggcctgc                 700
tgggcccgtt ggccattctg cttgccctgt acctgctaag aagagatcaa                 750
agactgcctc ccgatgccca caagcctcca ggaggagggt cattcagaac                 800
ccccatccag gaagaacagg cagacgctca ctctacgctc gcgaagatc                  849

<210>  152
<211>  807
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 59 (41BBLmincyto-OX40)

<400>  152
atgctggggc gcgaccagag gctgccacct gacgcacaca agccacctgg                 50
tgggggctca tttcgaactc ccatccagga agagcaggcc gacgcacaca                 100
gtacccttgc caaaatcact agtggaagtt gggctttggt ggccggactg                 150
ctgctcctgc tgctgctggc tgctgcctgt gccgtgtttc tcgcatgtcc                 200
ttgggctgtg tccggtgcaa gagcctctcc tggatctgcc gcgagtccgc                 250
gcctgcgaga gggaccagaa ttgtcaccgg atgaccctgc aggccttctc                 300
gatctcaggc aaggaatgtt tgcgcagctg gtggcacaaa acgtgttgct                 350
tatagacgga ccacttagct ggtattctga tcccggcctg gccggggttt                 400
cattgaccgg cggcctttcc tacaaggaag ataccaagga actggtggtc                 450
gccaaggccg gagtatacta tgttttcttc caattggagt tgcggcgcgt                 500
cgtggcaggg gaagggagcg gttctgtctc tttggctctc cacctgcaac                 550
ccttgagatc cgcggctgga gctgcagctt tggcgctcac tgttgacctg                 600
ccacctgcaa gttccgaggc tcggaactca gcgttcgggt ttcaaggcag                 650
actgctgcac ctgagcgccg ggcaaagact tggtgtacac ttgcacactg                 700
aggctagagc ccgccacgct tggcaactca cacaaggggc tacagtgctt                 750
ggcctgttcc gagtaacgcc cgaaattcca gcgggcctgc caagtcctag                 800
atctgaa                                                                807

<210>  153
<211>  843
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 60 (41BBL13W-OX40rev)

<400>  153
atggaaatca aggctctaac cagccacgcg gacgctcagg aagaacaaat                 50
tcccacccgc tttagtggtg gggggccacc taaacatgct gatcctccat                 100
tgcgacagga taggaggctg ctgtggccac cggcgccaag agctagagct                 150
tgcagagtgt tgccttgggc tttggtggcc ggactgctgc tcctgctgct                 200
gctggctgct gcctgtgccg tgtttctcgc atgtccttgg gctgtgtccg                 250
gtgcaagagc ctctcctgga tctgccgcga gtccgcgcct gcgagaggga                 300
ccagaattgt caccggatga ccctgcaggc cttctcgatc tcaggcaagg                 350
aatgtttgcg cagctggtgg cacaaaacgt gttgcttata gacggaccac                 400
ttagctggta ttctgatccc ggcctggccg gggtttcatt gaccggcggc                 450
ctttcctaca aggaagatac caaggaactg gtggtcgcca aggccggagt                 500
atactatgtt ttcttccaat tggagttgcg gcgcgtcgtg gcaggggaag                 550
ggagcggttc tgtctctttg gctctccacc tgcaaccctt gagatccgcg                 600
gctggagctg cagctttggc gctcactgtt gacctgccac ctgcaagttc                 650
cgaggctcgg aactcagcgt tcgggtttca aggcagactg ctgcacctga                 700
gcgccgggca aagacttggt gtacacttgc acactgaggc tagagcccgc                 750
cacgcttggc aactcacaca aggggctaca gtgcttggcc tgttccgagt                 800
aacgcccgaa attccagcgg gcctgccaag tcctagatct gaa                        843

<210>  154
<211>  807
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 61 (41BBL-mincyto-OX40rev)

<400>  154
atgctgggga tcaaggctct aaccagccac gcggacgctc aggaagaaca                 50
aattcccacc cgctttagtg gtggggggcc acctaaacat gctgatcctc                 100
cattgcgaca ggataggact agtggaagtt gggctttggt ggccggactg                 150
ctgctcctgc tgctgctggc tgctgcctgt gccgtgtttc tcgcatgtcc                 200
ttgggctgtg tccggtgcaa gagcctctcc tggatctgcc gcgagtccgc                 250
gcctgcgaga gggaccagaa ttgtcaccgg atgaccctgc aggccttctc                 300
gatctcaggc aaggaatgtt tgcgcagctg gtggcacaaa acgtgttgct                 350
tatagacgga ccacttagct ggtattctga tcccggcctg gccggggttt                 400
cattgaccgg cggcctttcc tacaaggaag ataccaagga actggtggtc                 450
gccaaggccg gagtatacta tgttttcttc caattggagt tgcggcgcgt                 500
cgtggcaggg gaagggagcg gttctgtctc tttggctctc cacctgcaac                 550
ccttgagatc cgcggctgga gctgcagctt tggcgctcac tgttgacctg                 600
ccacctgcaa gttccgaggc tcggaactca gcgttcgggt ttcaaggcag                 650
actgctgcac ctgagcgccg ggcaaagact tggtgtacac ttgcacactg                 700
aggctagagc ccgccacgct tggcaactca cacaaggggc tacagtgctt                 750
ggcctgttcc gagtaacgcc cgaaattcca gcgggcctgc caagtcctag                 800
atctgaa                                                                807

<210>  155
<211>  903
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 62 (41BBL-OX40ENrev)

<400>  155
atgctgggga tcaaggctct aaccagccac gcggacgctc aggaagaaca                 50
aattcccacc cgctttagtg gtggggggcc acctaaacat gctgatcctc                 100
cattgcgaca ggataggagg ctgctctacc tggctactag tggaagttat                 150
gccagtgacg catctctcga tcccgaagcc ccttggccac cggcgccaag                 200
agctagagct tgcagagtgt tgccttgggc tttggtggcc ggactgctgc                 250
tcctgctgct gctggctgct gcctgtgccg tgtttctcgc atgtccttgg                 300
gctgtgtccg gtgcaagagc ctctcctgga tctgccgcga gtccgcgcct                 350
gcgagaggga ccagaattgt caccggatga ccctgcaggc cttctcgatc                 400
tcaggcaagg aatgtttgcg cagctggtgg cacaaaacgt gttgcttata                 450
gacggaccac ttagctggta ttctgatccc ggcctggccg gggtttcatt                 500
gaccggcggc ctttcctaca aggaagatac caaggaactg gtggtcgcca                 550
aggccggagt atactatgtt ttcttccaat tggagttgcg gcgcgtcgtg                 600
gcaggggaag ggagcggttc tgtctctttg gctctccacc tgcaaccctt                 650
gagatccgcg gctggagctg cagctttggc gctcactgtt gacctgccac                 700
ctgcaagttc cgaggctcgg aactcagcgt tcgggtttca aggcagactg                 750
ctgcacctga gcgccgggca aagacttggt gtacacttgc acactgaggc                 800
tagagcccgc cacgcttggc aactcacaca aggggctaca gtgcttggcc                 850
tgttccgagt aacgcccgaa attccagcgg gcctgccaag tcctagatct                 900
gaa                                                                    903

<210>  156
<211>  903
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 63 (41BBL-OX40EN)

<400>  156
atgctggggg ccctgtacct gctcaggcgc gaccagaggc tgccacctga                 50
cgcacacaag ccacctggtg ggggctcatt tcgaactccc atccaggaag                 100
agcaggccga cgcacacagt acccttgcca aaatcactag tggaagttat                 150
gccagtgacg catctctcga tcccgaagcc ccttggccac cggcgccaag                 200
agctagagct tgcagagtgt tgccttgggc tttggtggcc ggactgctgc                 250
tcctgctgct gctggctgct gcctgtgccg tgtttctcgc atgtccttgg                 300
gctgtgtccg gtgcaagagc ctctcctgga tctgccgcga gtccgcgcct                 350
gcgagaggga ccagaattgt caccggatga ccctgcaggc cttctcgatc                 400
tcaggcaagg aatgtttgcg cagctggtgg cacaaaacgt gttgcttata                 450
gacggaccac ttagctggta ttctgatccc ggcctggccg gggtttcatt                 500
gaccggcggc ctttcctaca aggaagatac caaggaactg gtggtcgcca                 550
aggccggagt atactatgtt ttcttccaat tggagttgcg gcgcgtcgtg                 600
gcaggggaag ggagcggttc tgtctctttg gctctccacc tgcaaccctt                 650
gagatccgcg gctggagctg cagctttggc gctcactgtt gacctgccac                 700
ctgcaagttc cgaggctcgg aactcagcgt tcgggtttca aggcagactg                 750
ctgcacctga gcgccgggca aagacttggt gtacacttgc acactgaggc                 800
tagagcccgc cacgcttggc aactcacaca aggggctaca gtgcttggcc                 850
tgttccgagt aacgcccgaa attccagcgg gcctgccaag tcctagatct                 900
gaa                                                                    903

<210>  157
<211>  873
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 64 (41BBLmincyto-13alink-OX40)

<400>  157
atgctggggc gcgaccagag gctgccacct gacgcacaca agccacctgg                 50
tgggggctca tttcgaactc ccatccagga agagcaggcc gacgcacaca                 100
gtacccttgc caaaatcagt ttaaacggcg gaggtgggag cggaggtggc                 150
ggctccgggg gaggtggcag cggtggggga ggcagcggcg ggccttgggc                 200
tttggtggcc ggactgctgc tcctgctgct gctggctgct gcctgtgccg                 250
tgtttctcgc atgtccttgg gctgtgtccg gtgcaagagc ctctcctgga                 300
tctgccgcga gtccgcgcct gcgagaggga ccagaattgt caccggatga                 350
ccctgcaggc cttctcgatc tcaggcaagg aatgtttgcg cagctggtgg                 400
cacaaaacgt gttgcttata gacggaccac ttagctggta ttctgatccc                 450
ggcctggccg gggtttcatt gaccggcggc ctttcctaca aggaagatac                 500
caaggaactg gtggtcgcca aggccggagt atactatgtt ttcttccaat                 550
tggagttgcg gcgcgtcgtg gcaggggaag ggagcggttc tgtctctttg                 600
gctctccacc tgcaaccctt gagatccgcg gctggagctg cagctttggc                 650
gctcactgtt gacctgccac ctgcaagttc cgaggctcgg aactcagcgt                 700
tcgggtttca aggcagactg ctgcacctga gcgccgggca aagacttggt                 750
gtacacttgc acactgaggc tagagcccgc cacgcttggc aactcacaca                 800
aggggctaca gtgcttggcc tgttccgagt aacgcccgaa attccagcgg                 850
gcctgccaag tcctagatct gaa                                              873

<210>  158
<211>  627
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 65 (OX40Lmincyto-41BBrev)

<400>  158
atgctggggc tggagtgcgg cggcgaggag gaggagccct tcaggtgcag                 50
ctgcggcgac gaggagcaga ccacccaggt gcccaggatg ttcccccaga                 100
agttcatcta cctgctgaag aagaggggca ggaagctggg aggcagcctg                 150
ctccttgttg ctagtgtgat tcaggggctg ggactgttgt tgtgcttcac                 200
atacatttgt ctccactttt ctgcattgca ggtcagccat aggtatcccc                 250
gcattcagtc tatcaaagtg caattcactg agtacaagaa ggagaaaggc                 300
tttattttaa ctagtcaaaa ggaagacgag ataatgaagg tgcagaacaa                 350
cagcgttatt atcaattgcg acgggttcta tttaatctct ctgaaagggt                 400
acttctcaca ggaggttaac attagtttac attatcaaaa ggacgaggaa                 450
cccttgttcc agctgaaaaa agtgcggtct gttaattccc ttatggtggc                 500
gagtcttaca tacaaggaca aggtgtatct caacgtgaca acggacaata                 550
cctctctgga cgattttcac gttaacggcg gggagcttat acttatccat                 600
caaaacccag gagaattttg cgtcctt                                          627

<210>  159
<211>  549
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Sequence encoding SEQ ID NO: 66 (OX40L WT)

<400>  159
atggaacgtg ttcagccact ggaggaaaat gtcggcaacg ccgccaggcc                 50
tcgattcgag cgtaacaaac tgctccttgt tgctagtgtg attcaggggc                 100
tgggactgtt gttgtgcttc acatacattt gtctccactt ttctgcattg                 150
caggtcagcc ataggtatcc ccgcattcag tctatcaaag tgcaattcac                 200
tgagtacaag aaggagaaag gctttatttt aactagtcaa aaggaagacg                 250
agataatgaa ggtgcagaac aacagcgtta ttatcaattg cgacgggttc                 300
tatttaatct ctctgaaagg gtacttctca caggaggtta acattagttt                 350
acattatcaa aaggacgagg aacccttgtt ccagctgaaa aaagtgcggt                 400
ctgttaattc ccttatggtg gcgagtctta catacaagga caaggtgtat                 450
ctcaacgtga caacggacaa tacctctctg gacgattttc acgttaacgg                 500
cggggagctt atacttatcc atcaaaaccc aggagaattt tgcgtcctt                  549

<210>  160
<211>  624
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 67 (OX40Lmincyto-41BB)

<400>  160
atgctgggga agcggggcag aaagaaactg ctgtacatct ttaagcagcc                 50
cttcatgcgg cccgtgcaga ccacccagga agaggacggc tgctcctgca                 100
gattccccga ggaagaagaa ggcggctgcg agctgggagg cagcctgctc                 150
cttgttgcta gtgtgattca ggggctggga ctgttgttgt gcttcacata                 200
catttgtctc cacttttctg cattgcaggt cagccatagg tatccccgca                 250
ttcagtctat caaagtgcaa ttcactgagt acaagaagga gaaaggcttt                 300
attttaacta gtcaaaagga agacgagata atgaaggtgc agaacaacag                 350
cgttattatc aattgcgacg ggttctattt aatctctctg aaagggtact                 400
tctcacagga ggttaacatt agtttacatt atcaaaagga cgaggaaccc                 450
ttgttccagc tgaaaaaagt gcggtctgtt aattccctta tggtggcgag                 500
tcttacatac aaggacaagg tgtatctcaa cgtgacaacg gacaatacct                 550
ctctggacga ttttcacgtt aacggcgggg agcttatact tatccatcaa                 600
aacccaggag aattttgcgt cctt                                             624

<210>  161
<211>  987
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Sequence encoding SEQ ID NO: 68 (CD86 WT)

<400>  161
atggaccctc agtgtaccat gggcctgagc aacatcctgt tcgtgatggc                 50
ctttctgctg agcggagccg ctcctctgaa gatccaggcc tacttcaacg                 100
agacagccga cctgccttgc cagttcgcca acagccagaa tcagagcctg                 150
agcgagctgg tggtgttctg gcaggaccaa gagaacctgg tgctgaacga                 200
ggtgtacctg ggcaaagaaa agttcgacag cgtgcacagc aagtacatgg                 250
gcagaaccag cttcgactcc gacagctgga cactgagact gcacaacctg                 300
cagatcaagg acaagggcct gtaccagtgc atcatccacc acaagaaacc                 350
caccggcatg atcagaatcc accagatgaa cagcgagctg agcgtgctgg                 400
ccaacttcag ccagcctgag atcgtgccca tcagcaacat caccgagaac                 450
gtgtacatca acctgacctg cagcagcatc cacggctacc ccgagcctaa                 500
gaaaatgtcc gtgctgctgc ggaccaagaa cagcaccatc gagtacgacg                 550
gcgtgatgca gaaaagccag gacaacgtga ccgagctgta cgacgtgtcc                 600
atcagcctgt ccgtgtcatt ccccgacgtg accagcaata tgaccatctt                 650
ctgcatcctg gaaaccgaca agacccggct gctgtctagc cccttcagca                 700
tagagctgga agatccccag cctcctcctg atcacatccc ttggattacc                 750
gccgtgctgc ccaccgtgat catctgcgtg atggtgtttt gcctgatcct                 800
gtggaagtgg aagaagaaga aacggcctcg gaacagctac aagtgcggca                 850
ccaacaccat ggaacgggaa gagagcgagc agaccaagaa gagagagaag                 900
attcacatcc ccgagcggag cgacgaagcc cagagagtgt ttaagagcag                 950
caagaccagc agctgcgaca agagcgatac ctgcttc                               987

<210>  162
<211>  828
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 69 (CD86delP276)

<400>  162
atggaccctc agtgtaccat gggcctgagc aacatcctgt tcgtgatggc                 50
ctttctgctg agcggagccg ctcctctgaa gatccaggcc tacttcaacg                 100
agacagccga cctgccttgc cagttcgcca acagccagaa tcagagcctg                 150
agcgagctgg tggtgttctg gcaggaccaa gagaacctgg tgctgaacga                 200
ggtgtacctg ggcaaagaaa agttcgacag cgtgcacagc aagtacatgg                 250
gcagaaccag cttcgactcc gacagctgga cactgagact gcacaacctg                 300
cagatcaagg acaagggcct gtaccagtgc atcatccacc acaagaaacc                 350
caccggcatg atcagaatcc accagatgaa cagcgagctg agcgtgctgg                 400
ccaacttcag ccagcctgag atcgtgccca tcagcaacat caccgagaac                 450
gtgtacatca acctgacctg cagcagcatc cacggctacc ccgagcctaa                 500
gaaaatgtcc gtgctgctgc ggaccaagaa cagcaccatc gagtacgacg                 550
gcgtgatgca gaaaagccag gacaacgtga ccgagctgta cgacgtgtcc                 600
atcagcctgt ccgtgtcatt ccccgacgtg accagcaata tgaccatctt                 650
ctgcatcctg gaaaccgaca agacccggct gctgtctagc cccttcagca                 700
tcgagctgga agatccccag cctcctcctg atcacatccc ttggattacc                 750
gccgtgctgc ccaccgtgat catctgcgtg atggtgtttt gcctgatcct                 800
gtggaagtgg aagaagaaga aacggcct                                         828

<210>  163
<211>  804
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 70 (CD86mincyto)

<400>  163
atggaccctc agtgtaccat gggcctgagc aacatcctgt tcgtgatggc                 50
ctttctgctg agcggagccg ctcctctgaa gatccaggcc tacttcaacg                 100
agacagccga cctgccttgc cagttcgcca acagccagaa tcagagcctg                 150
agcgagctgg tggtgttctg gcaggaccaa gagaacctgg tgctgaacga                 200
ggtgtacctg ggcaaagaaa agttcgacag cgtgcacagc aagtacatgg                 250
gcagaaccag cttcgactcc gacagctgga cactgagact gcacaacctg                 300
cagatcaagg acaagggcct gtaccagtgc atcatccacc acaagaaacc                 350
caccggcatg atcagaatcc accagatgaa cagcgagctg agcgtgctgg                 400
ccaacttcag ccagcctgag atcgtgccca tcagcaacat caccgagaac                 450
gtgtacatca acctgacctg cagcagcatc cacggctacc ccgagcctaa                 500
gaaaatgtcc gtgctgctgc ggaccaagaa cagcaccatc gagtacgacg                 550
gcgtgatgca gaaaagccag gacaacgtga ccgagctgta cgacgtgtcc                 600
atcagcctgt ccgtgtcatt ccccgacgtg accagcaata tgaccatctt                 650
ctgcatcctg gaaaccgaca agacccggct gctgtctagc cccttcagca                 700
tagagctgga agatccccag cctcctcctg atcacatccc ttggattacc                 750
gccgtgctgc ccaccgtgat catctgcgtg atggtgtttt gcctgatcct                 800
gtgg                                                                   804

<210>  164
<211>  1470
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 71 (CD86mincyto-IL18RAP)

<400>  164
atggaccctc agtgtaccat gggcctgagc aacatcctgt tcgtgatggc                 50
ctttctgctg agcggagccg ctcctctgaa gatccaggcc tacttcaacg                 100
agacagccga cctgccttgc cagttcgcca acagccagaa tcagagcctg                 150
agcgagctgg tggtgttctg gcaggaccaa gagaacctgg tgctgaacga                 200
ggtgtacctg ggcaaagaaa agttcgacag cgtgcacagc aagtacatgg                 250
gcagaaccag cttcgactcc gacagctgga cactgagact gcacaacctg                 300
cagatcaagg acaagggcct gtaccagtgc atcatccacc acaagaaacc                 350
caccggcatg atcagaatcc accagatgaa cagcgagctg agcgtgctgg                 400
ccaacttcag ccagcctgag atcgtgccca tcagcaacat caccgagaac                 450
gtgtacatca acctgacctg cagcagcatc cacggctacc ccgagcctaa                 500
gaaaatgtcc gtgctgctgc ggaccaagaa cagcaccatc gagtacgacg                 550
gcgtgatgca gaaaagccag gacaacgtga ccgagctgta cgacgtgtcc                 600
atcagcctgt ccgtgtcatt ccccgacgtg accagcaata tgaccatctt                 650
ctgcatcctg gaaaccgaca agacccggct gctgtctagc cccttcagca                 700
tcgagctgga agatccccag cctcctcctg atcacatccc ttggattacc                 750
gccgtgctgc ccaccgtgat catctgcgtg atggtgtttt gcctgatcct                 800
gtggagcgcc ctgctgtacc ggcactggat cgagatcgtg ctgctgtaca                 850
gaacctacca gagcaaggac cagacactgg gcgacaagaa ggacttcgac                 900
gccttcgtgt cctacgccaa gtggtccagc tttcctagcg aggccacaag                 950
cagcctgagc gaggaacatc tggccctgag cctgtttcct gacgtgctgg                 1000
aaaacaaata cggctacagc ctgtgcctgc tcgagagaga tgttgctcct                 1050
ggcggagtgt acgccgagga catcgtgtcc atcatcaagc ggagcagacg                 1100
gggcatcttc attctgagcc ccaactacgt gaacggcccc agcatctttg                 1150
aactgcaagc cgccgtgaac ctggctctgg atgatcagac cctgaagctg                 1200
atcctgatca agttctgcta cttccaagag cctgagagcc tgcctcacct                 1250
ggtcaagaaa gccctgagag tgctgcctac cgtgacttgg agaggcctga                 1300
agtccgtgcc tcctaacagc agattctggg ccaagatgag ataccacatg                 1350
cctgtgaaga acagccaggg cttcacctgg aaccagctgc ggatcaccag                 1400
ccggatcttt cagtggaagg gcctgagcag aaccgagaca accggcagaa                 1450
gcagccagcc taaagagtgg                                                  1470

<210>  165
<211>  1653
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 72 (CD86-IL18RAP)

<400>  165
atggaccctc agtgtaccat gggcctgagc aacatcctgt tcgtgatggc                 50
ctttctgctg agcggagccg ctcctctgaa gatccaggcc tacttcaacg                 100
agacagccga cctgccttgc cagttcgcca acagccagaa tcagagcctg                 150
agcgagctgg tggtgttctg gcaggaccaa gagaacctgg tgctgaacga                 200
ggtgtacctg ggcaaagaaa agttcgacag cgtgcacagc aagtacatgg                 250
gcagaaccag cttcgactcc gacagctgga cactgagact gcacaacctg                 300
cagatcaagg acaagggcct gtaccagtgc atcatccacc acaagaaacc                 350
caccggcatg atcagaatcc accagatgaa cagcgagctg agcgtgctgg                 400
ccaacttcag ccagcctgag atcgtgccca tcagcaacat caccgagaac                 450
gtgtacatca acctgacctg cagcagcatc cacggctacc ccgagcctaa                 500
gaaaatgtcc gtgctgctgc ggaccaagaa cagcaccatc gagtacgacg                 550
gcgtgatgca gaaaagccag gacaacgtga ccgagctgta cgacgtgtcc                 600
atcagcctgt ccgtgtcatt ccccgacgtg accagcaata tgaccatctt                 650
ctgcatcctg gaaaccgaca agacccggct gctgtctagc cccttcagca                 700
tcgagctgga agatccccag cctcctcctg atcacatccc ttggattacc                 750
gccgtgctgc ccaccgtgat catctgcgtg atggtgtttt gcctgatcct                 800
gtggaagtgg aagaagaaga aacggcctcg gaacagctac aagtgcggca                 850
ccaacaccat ggaacgggaa gagagcgagc agaccaagaa gagagagaag                 900
attcacatcc ccgagcggag cgacgaagcc cagagagtgt ttaagagcag                 950
caagaccagc agctgcgaca agagcgatac ctgcttcagc gccctgctgt                 1000
accggcactg gatcgagatc gtgctgctgt acagaaccta ccagagcaag                 1050
gaccagacac tgggcgacaa gaaggacttc gacgccttcg tgtcctacgc                 1100
caagtggtcc agctttccta gcgaggccac aagcagcctg agcgaggaac                 1150
atctggccct gagcctgttt cctgacgtgc tggaaaacaa atacggctac                 1200
agcctgtgcc tgctcgagag agatgttgct cctggcggag tgtacgccga                 1250
ggacatcgtg tccatcatca agcggagcag acggggcatc ttcattctga                 1300
gccccaacta cgtgaacggc cccagcatct ttgaactgca agccgccgtg                 1350
aacctggctc tggatgatca gaccctgaag ctgatcctga tcaagttctg                 1400
ctacttccaa gagcctgaga gcctgcctca cctggtcaag aaagccctga                 1450
gagtgctgcc taccgtgact tggagaggcc tgaagtccgt gcctcctaac                 1500
agcagattct gggccaagat gagataccac atgcctgtga agaacagcca                 1550
gggcttcacc tggaaccagc tgcggatcac cagccggatc tttcagtgga                 1600
agggcctgag cagaaccgag acaaccggca gaagcagcca gcctaaagag                 1650
tgg                                                                    1653

<210>  166
<211>  1311
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 73 (CD86IgV-41BBL-OX40)

<400>  166
atgctggggc gcgaccagag gctgccacct gacgcacaca agccacctgg                 50
tgggggctca tttcgaactc ccatccagga agagcaggcc gacgcacaca                 100
gtacccttgc caaaatcact agtggaagtt atgccagtga cgcatctctc                 150
gatcccgaag ccccttggcc accggcgcca agagctagag cttgcagagt                 200
gttgccttgg gctttggtgg ccggactgct gctcctgctg ctgctggctg                 250
ctgcctgtgc cgtgtttctc gcatgtcctt gggctgtgtc cggtgcaaga                 300
gcctctcctg gatctgccgc gagtccgcgc ctgcgagagg gaccagaatt                 350
gtcaccggat gaccctgcag gccttctcga tctcaggcaa ggaatgtttg                 400
cgcagctggt ggcacaaaac gtgttgctta tagacggacc acttagctgg                 450
tattctgatc ccggcctggc cggggtttca ttgaccggcg gcctttccta                 500
caaggaagat accaaggaac tggtggtcgc caaggccgga gtatactatg                 550
ttttcttcca attggagttg cggcgcgtcg tggcagggga agggagcggt                 600
tctgtctctt tggctctcca cctgcaaccc ttgagatccg cggctggagc                 650
tgcagctttg gcgctcactg ttgacctgcc acctgcaagt tccgaggctc                 700
ggaactcagc gttcgggttt caaggcagac tgctgcacct gagcgccggg                 750
caaagacttg gtgtacactt gcacactgag gctagagccc gccacgcttg                 800
gcaactcaca caaggggcta cagtgcttgg cctgttccga gtaacgcccg                 850
aaattccagc gggcctgcca agtcctagat ctgaaagttt aaacggcgga                 900
ggtgggagcg gaggtggcgg ctccggggga ggtggcagcg gtgggggagg                 950
cagcggcggg ggaggtagca ctagtgcccc tctgaagatc caggcttact                 1000
tcaacgaaac cgcagatttg ccctgccagt ttgccaattc tcagaatcag                 1050
tctttatctg aactggtggt cttctggcag gaccaggaga atcttgtact                 1100
gaatgaagtt tatctcggca aggaaaagtt tgatagtgta catagtaagt                 1150
acatgggtag aacctccttc gattctgact cgtggacttt aaggctgcac                 1200
aacctgcaga tcaaggataa agggctttac cagtgcatta tccaccataa                 1250
gaagccaacc ggcatgattc ggattcatca gatgaactct gagctgtctg                 1300
tactcgccaa t                                                           1311

<210>  167
<211>  1839
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Sequence encoding SEQ ID NO: 74 (RANK WT)

<400>  167
atggccccta gagccagaag aagaaggcct ctgtttgccc tgctgctgct                 50
gtgcgctctg ctggctagac tgcaagtggc cctgcagatt gcccctccat                 100
gtaccagcga gaagcactac gagcacctgg gcagatgctg caacaagtgc                 150
gagcccggca agtacatgag cagcaagtgt accaccacca gcgacagcgt                 200
gtgtctgcct tgtggccctg acgagtacct ggacagctgg aacgaagagg                 250
acaagtgcct gctgcacaaa gtgtgcgata ccggcaaagc cctggtggca                 300
gtggtggccg gcaatagcac aacccctaga agatgtgcct gcaccgccgg                 350
ctatcactgg tcccaggatt gcgagtgctg cagacggaat accgagtgtg                 400
ctcctggact gggagcacag catcctctgc agctgaacaa ggacaccgtg                 450
tgcaagcctt gtctggccgg ctacttcagc gacgccttta gcagcaccga                 500
caagtgcaga ccctggacca actgcacctt cctgggcaag agagtggaac                 550
accacggcac cgagaagtcc gatgccgtgt gtagcggcag cagaaagcct                 600
cctaatgagc cccacgtgta cctgcctggc ctgatcatcc tgctgctttt                 650
tgctagcgtg gccctggtcg ccgccatcat ctttggcgtg tgctaccgga                 700
agaaaggcaa ggccctgacc gccaatctgt ggcactggat caatgaggcc                 750
tgcggcagac tgagcggcga caaagaaagc agcggcgact cctgtgtgtc                 800
tacccacacc gccaatttcg gacagcaggg cgcttgtgaa ggcgtgctgc                 850
ttctgaccct ggaagagaaa acattccccg aggacatgtg ctaccccgac                 900
caaggcggag tgtgtcaggg cacatgtgtt ggcggaggcc cttatgctca                 950
gggcgaagat gccagaatgc tgagcctggt gtccaagacc gagatcgagg                 1000
aagatagctt ccggcagatg cccaccgagg atgagtacat ggatagaccc                 1050
agccagccta ccgaccagct gctgtttctg acagagcctg gcagcaagag                 1100
cacccctcca ttttccgagc ctctggaagt gggcgagaac gacagcctga                 1150
gccagtgctt tacaggcacc cagagcacag tgggcagcga gagctgtaat                 1200
tgcaccgagc cactgtgccg gaccgactgg acacctatga gcagcgagaa                 1250
ctacctgcag aaagaggtgg actccggcca ctgtcctcat tgggctgcta                 1300
gcccctctcc taactgggcc gatgtgtgta ccggctgccg aaatccacct                 1350
ggcgaagatt gcgaacctct cgtgggcagc cctaaacgag gacctctgcc                 1400
tcagtgtgcc tacggcatgg gactgcctcc agaggaagag gccagcagaa                 1450
ccgaagccag agatcagcct gaagatggcg ccgatggcag actgcctagc                 1500
tctgctagag ctggcgctgg ctctggatct tctcctggcg gacaatctcc                 1550
tgccagcggc aatgtgaccg gcaacagcaa cagcaccttc atcagcagcg                 1600
gccaagtgat gaacttcaag ggcgacatca tcgtggtgta cgtgtcccag                 1650
acaagccaag aaggcgctgc cgcagctgct gaacctatgg gtagacccgt                 1700
gcaagaggaa accctggcca gaagagattc cttcgccggc aacggcccta                 1750
gattccctga tccttgtggc ggccctgaag gcctgagaga gcctgaaaaa                 1800
gccagccggc ctgtgcaaga acaaggcggc gctaaagct                             1839

<210>  168
<211>  690
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 75 (RANKmincyto)

<400>  168
atggccccta gagccagaag aagaaggcct ctgtttgccc tgctgctgct                 50
gtgcgctctg ctggctagac tgcaagtggc cctgcagatt gcccctccat                 100
gtaccagcga gaagcactac gagcacctgg gcagatgctg caacaagtgc                 150
gagcccggca agtacatgag cagcaagtgt accaccacca gcgacagcgt                 200
gtgtctgcct tgtggccctg acgagtacct ggacagctgg aacgaagagg                 250
acaagtgcct gctgcacaaa gtgtgcgata ccggcaaagc cctggtggca                 300
gtggtggccg gcaatagcac aacccctaga agatgtgcct gcaccgccgg                 350
ctatcactgg tcccaggatt gcgagtgctg cagacggaat accgagtgtg                 400
ctcctggact gggagcacag catcctctgc agctgaacaa ggacaccgtg                 450
tgcaagcctt gtctggccgg ctacttcagc gacgccttta gcagcaccga                 500
caagtgcaga ccctggacca actgcacctt cctgggcaag agagtggaac                 550
accacggcac cgagaagtcc gatgccgtgt gtagcggcag cagaaagcct                 600
cctaatgagc cccacgtgta cctgcctggc ctgatcatcc tgctgctttt                 650
tgctagcgtg gccctggtcg ccgccatcat ctttggcgtg                            690

<210>  169
<211>  816
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 76 (RANK-OX40)

<400>  169
atggcccctc gtgctcgacg taggcgtcca ttattcgctc tcctgctctt                 50
gtgcgcgctt ctcgctcggc tgcaggtggc cctccagatt gcgcccccat                 100
gcacttccga gaagcactat gaacatcttg gccgctgttg caataaatgt                 150
gaacctggca aatacatgtc ctccaaatgt actactacgt cagacagcgt                 200
gtgcttgccc tgtggacccg acgagtatct ggattcatgg aatgaggagg                 250
ataaatgcct cttgcataag gtctgtgata ctgggaaggc gctggtggct                 300
gtggtggctg gaaacagtac cacaccgcga cgatgcgctt gtactgccgg                 350
atatcactgg tctcaggatt gcgagtgctg tagacgtaat acagaatgtg                 400
cccccggcct tggcgctcag caccctctgc agttgaataa agacacagtc                 450
tgtaaaccct gtctggcagg gtatttctct gatgcattta gttctacaga                 500
caagtgtcgc ccttggacca actgtacttt ccttggtaag agggtggaac                 550
accacggcac agaaaagtcc gacgccgtct gttcaggctc ccggaaaccg                 600
cccaacgaac cacatgtgta tctgcccgtg gctgccattc tgggactggg                 650
gcttgtcttg gggctgctcg ggccattggc gatcctgctg gccctgtacc                 700
tgttgcggcg ggatcagcgc ctgcctccag atgcacataa accccccggc                 750
ggcgggtctt ttagaacacc aatacaagag gaacaagctg acgcccacag                 800
taccctcgca aaaatt                                                      816

<210>  170
<211>  834
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 77 (RANK-41BB)

<400>  170
atggcccctc gtgctcgacg taggcgtcca ttattcgctc tcctgctctt                 50
gtgcgcgctt ctcgctcggc tgcaggtggc cctccagatt gcgcccccat                 100
gcacttccga gaagcactat gaacatcttg gccgctgttg caataaatgt                 150
gaacctggca aatacatgtc ctccaaatgt actactacgt cagacagcgt                 200
gtgcttgccc tgtggacccg acgagtatct ggattcatgg aatgaggagg                 250
ataaatgcct cttgcataag gtctgtgata ctgggaaggc gctggtggct                 300
gtggtggctg gaaacagtac cacaccgcga cgatgcgctt gtactgccgg                 350
atatcactgg tctcaggatt gcgagtgctg tagacgtaat acagaatgtg                 400
cccccggcct tggcgctcag caccctctgc agttgaataa agacacagtc                 450
tgtaaaccct gtctggcagg gtatttctct gatgcattta gttctacaga                 500
caagtgtcgc ccttggacca actgtacttt ccttggtaag agggtggaac                 550
accacggcac agaaaagtcc gacgccgtct gttcaggctc ccggaaaccg                 600
cccaacgaac cacatgtgta tctgcccatt atttcttttt tcctggcact                 650
gacaagcaca gcgctgttat ttctcttatt ctttttgacc ctccgcttca                 700
gtgtcgtgaa gcgcgggcgc aaaaagttgc tgtacatttt taagcagcct                 750
tttatgagac ccgtgcagac cacccaggag gaagatggct gcagctgcag                 800
gttccccgag gaggaagagg gcggatgcga actc                                  834

<210>  171
<211>  1356
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 78 (RANK-IL18RAP)

<400>  171
atggccccta gagccagaag aagaaggcct ctgtttgccc tgctgctgct                 50
gtgcgctctg ctggctagac tgcaagtggc cctgcagatt gcccctccat                 100
gtaccagcga gaagcactac gagcacctgg gcagatgctg caacaagtgc                 150
gagcccggca agtacatgag cagcaagtgt accaccacca gcgacagcgt                 200
gtgtctgcct tgtggccctg acgagtacct ggacagctgg aacgaagagg                 250
acaagtgcct gctgcacaaa gtgtgcgata ccggcaaagc cctggtggca                 300
gtggtggccg gcaatagcac aacccctaga agatgtgcct gcaccgccgg                 350
ctatcactgg tcccaggatt gcgagtgctg cagacggaat accgagtgtg                 400
ctcctggact gggagcacag catcctctgc agctgaacaa ggacaccgtg                 450
tgcaagcctt gtctggccgg ctacttcagc gacgccttta gcagcaccga                 500
caagtgcaga ccctggacca actgcacctt cctgggcaag agagtggaac                 550
accacggcac cgagaagtcc gatgccgtgt gtagcggcag cagaaagcct                 600
cctaatgagc cccacgtgta cctgcctggt gtagtcctgc tctacatcct                 650
gctgggcaca atcgggactc tggtggctgt gctggctgcc agcgccctgc                 700
tgtaccggca ctggatcgag atcgtgctgc tgtacagaac ctaccagagc                 750
aaggaccaga cactgggcga caagaaggac ttcgacgcct tcgtgtccta                 800
cgccaagtgg tccagctttc ctagcgaggc cacaagcagc ctgagcgagg                 850
aacatctggc cctgagcctg tttcctgacg tgctggaaaa caaatacggc                 900
tacagcctgt gcctgctcga gagagatgtt gctcctggcg gagtgtacgc                 950
cgaggacatc gtgtccatca tcaagcggag cagacggggc atcttcattc                 1000
tgagccccaa ctacgtgaac ggccccagca tctttgaact gcaagccgcc                 1050
gtgaacctgg ctctggatga tcagaccctg aagctgatcc tgatcaagtt                 1100
ctgctacttc caagagcctg agagcctgcc tcacctggtc aagaaagccc                 1150
tgagagtgct gcctaccgtg acttggagag gcctgaagtc cgtgcctcct                 1200
aacagcagat tctgggccaa gatgagatac cacatgcctg tgaagaacag                 1250
ccagggcttc acctggaacc agctgcggat caccagccgg atctttcagt                 1300
ggaagggcct gagcagaacc gagacaaccg gcagaagcag ccagcctaaa                 1350
gagtgg                                                                 1356

<210>  172
<211>  414
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 80 (CD8-Q8)

<400>  172
atgggactcg ttagaagagg cgccagagcc ggacctagaa tccctagagg                 50
atggacagcc ctgtgcctgc tgtctctgct gccttctggc tttatggccg                 100
agctgcctac acagggcacc ttcagcaatg tgtccaccaa cgtgtcccca                 150
gccaagccta caacaacccc tgctcctaga cctcctacac cagctcctac                 200
aatcgccagc cagccactgt ctctgaggcc agaagcttgt agacctgctg                 250
ctggcggagc cgtgcataca agaggactgg atttcgcctg cgacatctac                 300
atctgggccc ctctggctgg aacatgtggc gttctgctgc tgagcctggt                 350
catcaccctg tactgcaacc accggaacag gcggagagtg tgcaagtgcc                 400
ctagacctgt ggtt                                                        414

<210>  173
<211>  717
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 81 (eGFP)

<400>  173
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt                 50
cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg                 100
gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc                 150
accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta                 200
cggcgtgcag tgcttcagcc gctaccccga ccacatgaag cagcacgact                 250
tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc                 300
ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg                 350
cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg                 400
acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac                 450
gtctatatca tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa                 500
gatccgccac aacatcgagg acggcagcgt gcagctcgcc gaccactacc                 550
agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac                 600
tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga                 650
tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca                 700
tggacgagct gtacaag                                                     717

<210>  174
<211>  155
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70

<400>  174
Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu 
1               5                   10                  15  

Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln 
                20                  25                  30  

Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg 
                35                  40                  45  

Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile 
                50                  55                  60  

His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala 
                65                  70                  75  

Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
                80                  85                  90  

Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu 
                95                  100                 105 

Arg Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu 
                110                 115                 120 

Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly 
                125                 130                 135 

Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val 
                140                 145                 150 

Gln Trp Val Arg Pro 
                155 

<210>  175
<211>  94
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL2RB ICD

<400>  175
Val Leu His Thr Pro Asp Gln Gly Gln Leu Glu Gln Leu Ser Leu 
1               5                   10                  15  

Tyr Ala Asp Thr Asn Leu Pro Leu Leu Gln Thr Val Lys Asp Arg 
                20                  25                  30  

Glu Leu Val Glu Leu Pro Ser Ile Glu Pro Ala Leu Gly Gly Pro 
                35                  40                  45  

Ser Phe Ser Ser Ser Pro Phe Pro Ser Ser Leu Trp Lys Gln Val 
                50                  55                  60  

Asp Gly Gly His Glu Ser Ser Leu Gln Ser Phe Phe Lys Ser Pro 
                65                  70                  75  

Asp Pro Thr Asn Cys Lys Leu Val Lys Lys Leu Trp Pro Gly Thr 
                80                  85                  90  

Asn Arg Cys Asn 
                

<210>  176
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70 ICD

<400>  176
Met Leu Gly Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg 
1               5                   10                  15  

Pro Tyr Gly 
            

<210>  177
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70 -TM

<400>  177
Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
1               5                   10                  15  

Cys Leu Val Val Cys Ile 
                20      

<210>  178
<211>  283
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-13W-OX40

<400>  178
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Trp Pro 
                35                  40                  45  

Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu 
                50                  55                  60  

Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala 
                65                  70                  75  

Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser 
                80                  85                  90  

Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
                95                  100                 105 

Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 
                110                 115                 120 

Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
                125                 130                 135 

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
                140                 145                 150 

Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
                155                 160                 165 

Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
                170                 175                 180 

Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                185                 190                 195 

Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                200                 205                 210 

Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
                215                 220                 225 

Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
                230                 235                 240 

Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
                245                 250                 255 

Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
                260                 265                 270 

Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                275                 280             

<210>  179
<211>  392
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40-IL2RB

<400>  179
Met Leu Gly Val Leu His Thr Pro Asp Gln Gly Gln Leu Glu Gln 
1               5                   10                  15  

Leu Ser Leu Tyr Ala Asp Thr Asn Leu Pro Leu Leu Gln Thr Val 
                20                  25                  30  

Lys Asp Arg Glu Leu Val Glu Leu Pro Ser Ile Glu Pro Ala Leu 
                35                  40                  45  

Gly Gly Pro Ser Phe Ser Ser Ser Pro Phe Pro Ser Ser Leu Trp 
                50                  55                  60  

Lys Gln Val Asp Gly Gly His Glu Ser Ser Leu Gln Ser Phe Phe 
                65                  70                  75  

Lys Ser Pro Asp Pro Thr Asn Cys Lys Leu Val Lys Lys Leu Trp 
                80                  85                  90  

Pro Gly Thr Asn Arg Cys Asn Gly Ser Gly Arg Asp Gln Arg Leu 
                95                  100                 105 

Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr 
                110                 115                 120 

Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys 
                125                 130                 135 

Ile Thr Ser Gly Ser Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu 
                140                 145                 150 

Ala Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu 
                155                 160                 165 

Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala 
                170                 175                 180 

Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly 
                185                 190                 195 

Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu 
                200                 205                 210 

Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
                215                 220                 225 

Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                230                 235                 240 

Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
                245                 250                 255 

Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
                260                 265                 270 

Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
                275                 280                 285 

Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
                290                 295                 300 

Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
                305                 310                 315 

Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
                320                 325                 330 

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
                335                 340                 345 

Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
                350                 355                 360 

Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
                365                 370                 375 

Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg 
                380                 385                 390 

Ser Glu 
        

<210>  180
<211>  195
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD70

<400>  180
Met Leu Gly Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg 
1               5                   10                  15  

Pro Tyr Gly Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala 
                20                  25                  30  

Gly Leu Val Ile Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln 
                35                  40                  45  

Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp Val Ala 
                50                  55                  60  

Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu 
                65                  70                  75  

Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly 
                80                  85                  90  

Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile 
                95                  100                 105 

Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr 
                110                 115                 120 

Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys 
                125                 130                 135 

Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His 
                140                 145                 150 

Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg 
                155                 160                 165 

Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser 
                170                 175                 180 

Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
                185                 190                 195 




<210>  181
<211>  180
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70mincyto

<400>  181
Met Leu Gly Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala 
1               5                   10                  15  

Gly Leu Val Ile Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln 
                20                  25                  30  

Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp Val Ala 
                35                  40                  45  

Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu 
                50                  55                  60  

Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly 
                65                  70                  75  

Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile 
                80                  85                  90  

Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr 
                95                  100                 105 

Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys 
                110                 115                 120 

Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His 
                125                 130                 135 

Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg 
                140                 145                 150 

Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser 
                155                 160                 165 

Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
                170                 175                 180 




<210>  182
<211>  221
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70mincyto-OX40

<400>  182
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Gly Cys 
                35                  40                  45  

Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
                50                  55                  60  

Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln 
                65                  70                  75  

Leu Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu 
                80                  85                  90  

Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly 
                95                  100                 105 

Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp 
                110                 115                 120 

Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile Tyr Met Val His 
                125                 130                 135 

Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg 
                140                 145                 150 

His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ser 
                155                 160                 165 

Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly Cys Thr 
                170                 175                 180 

Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr Leu 
                185                 190                 195 

Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp 
                200                 205                 210 

Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
                215                 220     

<210>  183
<211>  245
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70-41BBL-OX40

<400>  183
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu 
                95                  100                 105 

Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln 
                110                 115                 120 

Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg 
                125                 130                 135 

Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile 
                140                 145                 150 

His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala 
                155                 160                 165 

Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
                170                 175                 180 

Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu 
                185                 190                 195 

Arg Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu 
                200                 205                 210 

Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly 
                215                 220                 225 

Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val 
                230                 235                 240 

Gln Trp Val Arg Pro 
                245 

<210>  184
<211>  486
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD19.BB.Z

<400>  184
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
1               5                   10                  15  

Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser 
                20                  25                  30  

Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
                35                  40                  45  

Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
                50                  55                  60  

Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu 
                65                  70                  75  

His Ser Cys Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                80                  85                  90  

Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala 
                95                  100                 105 

Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
                110                 115                 120 

Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly 
                125                 130                 135 

Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
                140                 145                 150 

Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
                155                 160                 165 

Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile 
                170                 175                 180 

Arg Gln Pro Pro Arg Lys Cys Leu Glu Trp Leu Gly Val Ile Trp 
                185                 190                 195 

Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
                200                 205                 210 

Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met 
                215                 220                 225 

Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
                230                 235                 240 

His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255 

Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
                260                 265                 270 

Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                275                 280                 285 

Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                290                 295                 300 

Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                305                 310                 315 

Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                320                 325                 330 

Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                335                 340                 345 

Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                350                 355                 360 

Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                365                 370                 375 

Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                380                 385                 390 

Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                395                 400                 405 

Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                410                 415                 420 

Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                425                 430                 435 

Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                440                 445                 450 

Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                455                 460                 465 

Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                470                 475                 480 

Gln Ala Leu Pro Pro Arg 
                485     

<210>  185
<211>  849
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 178 (41BBL-13W-OX40)

<400>  185
atgctggggc gcgaccagag gctgccacct gacgcacaca agccacctgg                 50
tgggggctca tttcgaactc ccatccagga agagcaggcc gacgcacaca                 100
gtacccttgc caaaatcact agtggaagtt ggccaccggc gccaagagct                 150
agagcttgca gagtgttgcc ttgggctttg gtggccggac tgctgctcct                 200
gctgctgctg gctgctgcct gtgccgtgtt tctcgcatgt ccttgggctg                 250
tgtccggtgc aagagcctct cctggatctg ccgcgagtcc gcgcctgcga                 300
gagggaccag aattgtcacc ggatgaccct gcaggccttc tcgatctcag                 350
gcaaggaatg tttgcgcagc tggtggcaca aaacgtgttg cttatagacg                 400
gaccacttag ctggtattct gatcccggcc tggccggggt ttcattgacc                 450
ggcggccttt cctacaagga agataccaag gaactggtgg tcgccaaggc                 500
cggagtatac tatgttttct tccaattgga gttgcggcgc gtcgtggcag                 550
gggaagggag cggttctgtc tctttggctc tccacctgca acccttgaga                 600
tccgcggctg gagctgcagc tttggcgctc actgttgacc tgccacctgc                 650
aagttccgag gctcggaact cagcgttcgg gtttcaaggc agactgctgc                 700
acctgagcgc cgggcaaaga cttggtgtac acttgcacac tgaggctaga                 750
gcccgccacg cttggcaact cacacaaggg gctacagtgc ttggcctgtt                 800
ccgagtaacg cccgaaattc cagcgggcct gccaagtcct agatctgaa                  849

<210>  186
<211>  1176
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 179 (41BBL-OX40-IL2RB)

<400>  186
atgctggggg tgctgcacac accagatcag ggacagctgg aacagctgag                 50
cctgtacgcc gacaccaatc tgcctctgct gcagaccgtg aaggaccgcg                 100
aactggtgga actgcctagc atcgaacctg ctctcggcgg acctagcttt                 150
agcagcagcc catttcctag cagcctgtgg aaacaggtgg acggcggcca                 200
cgaatctagc ctgcagagct tcttcaagag ccccgatcct accaactgca                 250
agctggtcaa gaagctgtgg cccggcacca acagatgcaa cggcagcggc                 300
cgcgaccaga ggctgccacc tgacgcacac aagccacctg gtgggggctc                 350
atttcgaact cccatccagg aagagcaggc cgacgcacac agtacccttg                 400
ccaaaatcac tagtggaagt tatgccagtg acgcatctct cgatcccgaa                 450
gccccttggc caccggcgcc aagagctaga gcttgcagag tgttgccttg                 500
ggctttggtg gccggactgc tgctcctgct gctgctggct gctgcctgtg                 550
ccgtgtttct cgcatgtcct tgggctgtgt ccggtgcaag agcctctcct                 600
ggatctgccg cgagtccgcg cctgcgagag ggaccagaat tgtcaccgga                 650
tgaccctgca ggccttctcg atctcaggca aggaatgttt gcgcagctgg                 700
tggcacaaaa cgtgttgctt atagacggac cacttagctg gtattctgat                 750
cccggcctgg ccggggtttc attgaccggc ggcctttcct acaaggaaga                 800
taccaaggaa ctggtggtcg ccaaggccgg agtatactat gttttcttcc                 850
aattggagtt gcggcgcgtc gtggcagggg aagggagcgg ttctgtctct                 900
ttggctctcc acctgcaacc cttgagatcc gcggctggag ctgcagcttt                 950
ggcgctcact gttgacctgc cacctgcaag ttccgaggct cggaactcag                 1000
cgttcgggtt tcaaggcaga ctgctgcacc tgagcgccgg gcaaagactt                 1050
ggtgtacact tgcacactga ggctagagcc cgccacgctt ggcaactcac                 1100
acaaggggct acagtgcttg gcctgttccg agtaacgccc gaaattccag                 1150
cgggcctgcc aagtcctaga tctgaa                                           1176

<210>  187
<211>  585
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 180 (CD70)

<400>  187
atgctgggac ctgaggaggg cagcggctgc agcgtgagga ggaggcccta                 50
cggctgcgtg ctgagggccg ccctggtgcc cctggtggcc ggcctggtga                 100
tctgcctggt ggtgtgcatc cagaggttcg cccaggccca gcagcagctg                 150
cccctggaga gcctgggctg ggacgtggcc gagctgcagc tgaaccacac                 200
cggcccccag caggacccta gactgtactg gcaaggcgga cctgctctgg                 250
gcagatcttt tctgcacggc cccgagctgg ataagggcca gctgagaatc                 300
caccgcgacg gcatctacat ggtgcacatc caagtgaccc tggccatctg                 350
cagcagcacc acagcctcta gacatcaccc taccacactg gccgtgggca                 400
tctgttctcc agccagcaga tctatcagcc tgctgcggct gagcttccac                 450
cagggatgta caatcgccag ccagagactg acccctctgg ctagaggcga                 500
taccctgtgc accaatctga ccggcacact gctgcccagc cggaacaccg                 550
atgagacatt ctttggcgtg cagtgggtcc gacct                                 585

<210>  188
<211>  540
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 181 (CD70-mincyto)

<400>  188
atgctggggt gcgtgctgag ggccgccctg gtgcccctgg tggccggcct                 50
ggtgatctgc ctggtggtgt gcatccagag gttcgcccag gcccagcagc                 100
agctgcccct ggagagcctg ggctgggacg tggccgagct gcagctgaac                 150
cacaccggcc cccagcagga ccctagactg tactggcaag gcggacctgc                 200
tctgggcaga tcttttctgc acggccccga gctggataag ggccagctga                 250
gaatccaccg cgacggcatc tacatggtgc acatccaagt gaccctggcc                 300
atctgcagca gcaccacagc ctctagacat caccctacca cactggccgt                 350
gggcatctgt tctccagcca gcagatctat cagcctgctg cggctgagct                 400
tccaccaggg atgtacaatc gccagccaga gactgacccc tctggctaga                 450
ggcgataccc tgtgcaccaa tctgaccggc acactgctgc ccagccggaa                 500
caccgatgag acattctttg gcgtgcagtg ggtccgacct                            540

<210>  189
<211>  663
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 182 (CD70-mincyto-OX40)

<400>  189
atgctggggc gcgaccagag gctgccacct gacgcacaca agccacctgg                 50
tgggggctca tttcgaactc ccatccagga agagcaggcc gacgcacaca                 100
gtacccttgc caaaatcact agtggaagtg gatgcgtgct gagggccgcc                 150
ctggtgcccc tggtggccgg cctggtgatc tgcctggtgg tgtgcatcca                 200
gaggttcgcc caggcccagc agcagctgcc cctggagagc ctgggctggg                 250
acgtggccga gctgcagctg aaccacaccg gcccccagca ggaccctaga                 300
ctgtactggc aaggcggacc tgctctgggc agatcttttc tgcacggccc                 350
cgagctggat aagggccagc tgagaatcca ccgcgacggc atctacatgg                 400
tgcacatcca agtgaccctg gccatctgca gcagcaccac agcctctaga                 450
catcacccta ccacactggc cgtgggcatc tgttctccag ccagcagatc                 500
tatcagcctg ctgcggctga gcttccacca gggatgtaca atcgccagcc                 550
agagactgac ccctctggct agaggcgata ccctgtgcac caatctgacc                 600
ggcacactgc tgcccagccg gaacaccgat gagacattct ttggcgtgca                 650
gtgggtccga cct                                                         663

<210>  190
<211>  735
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence encoding SEQ ID NO: 183 (CD70EC-41BBL-OX40)

<400>  190
atgctggggc gcgaccagag gctgccacct gacgcacaca agccacctgg                 50
tgggggctca tttcgaactc ccatccagga agagcaggcc gacgcacaca                 100
gtacccttgc caaaatcact agtggaagtt atgccagtga cgcatctctc                 150
gatcccgaag ccccttggcc accggcgcca agagctagag cttgcagagt                 200
gttgccttgg gctttggtgg ccggactgct gctcctgctg ctgctggctg                 250
ctgcctgtgc cgtgtttctc cagaggttcg cccaggccca gcagcagctg                 300
cccctggaga gcctgggctg ggacgtggcc gagctgcagc tgaaccacac                 350
cggcccccag caggacccta gactgtactg gcaaggcgga cctgctctgg                 400
gcagatcttt tctgcacggc cccgagctgg ataagggcca gctgagaatc                 450
caccgcgacg gcatctacat ggtgcacatc caagtgaccc tggccatctg                 500
cagcagcacc acagcctcta gacatcaccc taccacactg gccgtgggca                 550
tctgttctcc agccagcaga tctatcagcc tgctgcggct gagcttccac                 600
cagggatgta caatcgccag ccagagactg acccctctgg ctagaggcga                 650
taccctgtgc accaatctga ccggcacact gctgcccagc cggaacaccg                 700
atgagacatt ctttggcgtg cagtgggtcc gacct                                 735

<210>  191
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA

<400>  191
acaaaacugu gcuagacaug                                                  20

<210>  192
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA

<400>  192
gagaaucaaa aucggugaau                                                  20

<210>  193
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA

<400>  193
cucucagcug guacacggca                                                  20

<210>  194
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA

<400>  194
acccgagguc gcuguguuug                                                  20

<210>  195
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA

<400>  195
aggucgcugu guuugagcca                                                  20

<210>  196
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA

<400>  196
cgaccacgug gagcugagcu                                                  20

<210>  197
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA

<400>  197
gauacugccu gagcagccgc                                                  20

<210>  198
<211>  316
<212>  PRT
<213>  Homo sapiens

<220>
<223>  NY-ESO-1 TRB with furin site

<400>  198
Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp 
1               5                   10                  15  

Ala Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln 
                20                  25                  30  

Val Leu Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp 
                35                  40                  45  

Met Asn His Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met 
                50                  55                  60  

Gly Leu Arg Leu Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp 
                65                  70                  75  

Gln Gly Glu Val Pro Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr 
                80                  85                  90  

Glu Asp Phe Pro Leu Arg Leu Leu Ser Ala Ala Pro Ser Gln Thr 
                95                  100                 105 

Ser Val Tyr Phe Cys Ala Ser Ser Tyr Val Gly Asn Thr Gly Glu 
                110                 115                 120 

Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr Val Leu Glu Asp Leu 
                125                 130                 135 

Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu 
                140                 145                 150 

Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
                155                 160                 165 

Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
                170                 175                 180 

Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu 
                185                 190                 195 

Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
                200                 205                 210 

Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
                215                 220                 225 

Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
                230                 235                 240 

Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255 

Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
                260                 265                 270 

Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
                275                 280                 285 

Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu 
                290                 295                 300 

Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly Arg Ala Lys Arg 
                305                 310                 315 

Ser 
    

<210>  199
<211>  274
<212>  PRT
<213>  Homo sapiens

<220>
<223>  NY-ESO-1 TRA

<400>  199
Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln 
1               5                   10                  15  

Trp Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu 
                20                  25                  30  

Ser Val Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr 
                35                  40                  45  

Asp Ser Ala Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly 
                50                  55                  60  

Lys Gly Leu Thr Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu 
                65                  70                  75  

Gln Thr Ser Gly Arg Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly 
                80                  85                  90  

Arg Ser Thr Leu Tyr Ile Ala Ala Ser Gln Pro Gly Asp Ser Ala 
                95                  100                 105 

Thr Tyr Leu Cys Ala Val Arg Pro Leu Tyr Gly Gly Ser Tyr Ile 
                110                 115                 120 

Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His Pro Tyr Ile 
                125                 130                 135 

Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
                140                 145                 150 

Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
                155                 160                 165 

Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                170                 175                 180 

Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
                185                 190                 195 

Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
                200                 205                 210 

Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
                215                 220                 225 

Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
                230                 235                 240 

Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255 

Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
                260                 265                 270 

Leu Trp Ser Ser 
                

<210>  200
<211>  948
<212>  DNA
<213>  Homo sapiens

<220>
<223>  NY-ESO-1 TRB DNA

<400>  200
atgtctatcg gcctgctgtg ttgtgccgct ctgtctctgc tttgggccgg                 50
acctgttaat gccggcgtga cccagacacc taagttccag gtgctgaaaa                 100
ccggccagag catgaccctg cagtgcgccc aggatatgaa ccacgagtac                 150
atgagctggt acagacagga ccctggcatg ggcctgagac tgatccacta                 200
ttctgtcgga gccggcatca ccgaccaggg cgaagttcct aatggctaca                 250
acgtgtccag aagcaccacc gaggacttcc cactgagact gctgtctgcc                 300
gctcctagcc agaccagcgt gtacttttgt gccagcagct acgtgggcaa                 350
caccggcgag ctgttttttg gcgagggcag cagactgacc gtgctggaag                 400
atctgaagaa cgtgttccca ccagaggtgg ccgtgttcga gccttctgag                 450
gccgagatca gccacacaca gaaagccaca ctcgtgtgtc tggccaccgg                 500
cttctatccc gatcacgtgg aactgtcttg gtgggtcaac ggcaaagagg                 550
tgcacagcgg cgtcagcaca gatccccagc ctctgaaaga acagcccgct                 600
ctgaacgaca gccggtactg tctgtcctcc agactgagag tgtccgccac                 650
cttctggcag aaccccagaa accacttcag atgccaggtg cagttctacg                 700
gcctgagcga gaacgatgag tggacccagg atagagccaa gcctgtgaca                 750
cagatcgtgt ctgccgaagc ctggggcaga gccgattgtg gctttaccag                 800
cgagagctac cagcagggcg ttctgtctgc caccatcctg tacgagatcc                 850
tgctgggcaa agccactctg tacgccgtgc tggtgtctgc cctggtgctg                 900
atggccatgg tcaagcggaa ggacagtaga ggcagagcca agagaagc                   948

<210>  201
<211>  822
<212>  DNA
<213>  Homo sapiens

<220>
<223>  NY-ESO-1 TRA DNA

<400>  201
atggaaacac tgctgggcct gctgatcctg tggctgcaac tgcaatgggt                 50
gtcctccaag caagaagtga ctcagatccc agccgctctg agtgtgccag                 100
agggcgaaaa cctggtcctg aactgcagct tcaccgacag cgccatctac                 150
aacctgcagt ggttcagaca agatcccggc aagggactga ccagcctgct                 200
gctgattcag agcagccaga gagagcagac ctccggcaga ctgaatgcca                 250
gcctggataa gagcagcggc cggtctacac tgtatatcgc cgcatctcag                 300
cctggcgata gcgccacata tctgtgtgcc gtgcgacctc tgtacggcgg                 350
cagctacatc cctacatttg gcagaggcac cagcctgatc gtgcacccct                 400
acattcagaa ccccgatcct gccgtgtatc agctgagaga cagcaagtcc                 450
agcgacaaga gcgtgtgcct gttcaccgac ttcgactccc agaccaatgt                 500
gtcccagagc aaggacagcg acgtgtacat caccgataag acagtgctgg                 550
acatgcggag catggacttc aagagcaaca gcgccgtggc ctggtccaac                 600
aagagcgatt tcgcctgcgc caacgccttc aacaacagca ttatccccga                 650
ggacacattc ttcccaagtc ctgagagcag ctgcgacgtg aagctggtgg                 700
aaaagagctt cgagacagac accaacctga acttccagaa cctgagcgtg                 750
atcggcttcc ggattctgct gctcaaggtg gccggcttca acctgctgat                 800
gaccctgaga ctctggtcca gc                                               822

<210>  202
<211>  367
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MSCV promoter

<400>  202
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt                 50
tgcaaggcat ggaaaataca taactgagaa tagagaagtt cagatcaagg                 100
ttaggaacag agagacagca gaatatgggc caaacaggat atctgtggta                 150
agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg                 200
gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc                 250
ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt                 300
cgcttctcgc ttctgttcgc gcgtttctgc tccccgagct caataaaaga                 350
gcccacaacc cctcact                                                     367

<210>  203
<211>  594
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MMLV promoter

<400>  203
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat                 50
tttgcaaggc atggaaaaat acataactga gaatagaaaa gttcagatca                 100
aggtcaggaa cagatggaac agctgaatat gggccaaaca ggatatctgt                 150
ggtaagcagt tcctgccccg gctcagggcc aagaacagat ggaacagctg                 200
aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca                 250
gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct                 300
agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct                 350
gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc                 400
gcttatgctc cccgagctca ataaaagagc ccacaacccc tcactcgggg                 450
cgccagtcct ccgattgact gagtcgcccg ggtacccgtg tatccaataa                 500
accctcttgc agttgcatcc gacttgtggt ctcgctgttc cttgggaggg                 550
tctcctctga gtgattgact acccgtcagc gggggtcttt catt                       594

<210>  204
<211>  1182
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EF1a  promoter

<400>  204
gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag                 50
aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg                 100
cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg                 150
agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt                 200
tttcgcaacg ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc                 250
ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg ccttgaatta                 300
cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt                 350
tggaagtggg tgggagagtt cgaggccttg cgcttaagga gccccttcgc                 400
ctcgtgcttg agttgaggcc tggcttgggc gctggggccg ccgcgtgcga                 450
atctggtggc accttcgcgc ctgtctcgct gctttcgata agtctctagc                 500
catttaaaat ttttgatgac ctgctgcgac gctttttttc tggcaagata                 550
gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc ggtttttggg                 600
gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag                 650
gcggggcctg cgagcgcggc caccgagaat cggacggggg tagtctcaag                 700
ctggccggcc tgctctggtg cctggcctcg cgccgccgtg tatcgccccg                 750
ccctgggcgg caaggctggc ccggtcggca ccagttgcgt gagcggaaag                 800
atggccgctt cccggccctg ctgcagggag ctcaaaatgg aggacgcggc                 850
gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa aagggccttt                 900
ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc                 950
caggcacctc gattagttct cgagcttttg gagtacgtcg tctttaggtt                 1000
ggggggaggg gttttatgcg atggagtttc cccacactga gtgggtggag                 1050
actgaagtta ggccagcttg gcacttgatg taattctcct tggaatttgc                 1100
cctttttgag tttggatctt ggttcattct caagcctcag acagtggttc                 1150
aaagtttttt tcttccattt caggtgtcgt ga                                    1182

<210>  205
<211>  399
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MND promoter

<400>  205
tttatttagt ctccagaaaa aggggggaat gaaagacccc acctgtaggt                 50
ttggcaagct aggatcaagg ttaggaacag agagacagca gaatatgggc                 100
caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga                 150
acagttggaa cagcagaata tgggccaaac aggatatctg tggtaagcag                 200
ttcctgcccc ggctcagggc caagaacaga tggtccccag atgcggtccc                 250
gccctcagca gtttctagag aaccatcaga tgtttccagg gtgccccaag                 300
gacctgaaat gaccctgtgc cttatttgaa ctaaccaatc agttcgcttc                 350
tcgcttctgt tcgcgcgctt ctgctccccg agctcaataa aagagccca                  399

<210>  206
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P2A

<400>  206
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
1               5                   10                  15  

Asn Pro Gly Pro 
                

<210>  207
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P2A DNA

<400>  207
gccaccaatt tcagcctgct gaaacaggct ggcgacgtgg aagagaaccc                 50
tgggccc                                                                57

<210>  208
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T2A

<400>  208
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
1               5                   10                  15  

Pro Gly Pro 
            

<210>  209
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  T2A DNA

<400>  209
gaaggccgcg gcagcctgct gacctgcgga gacgtggaag aaaaccctgg                 50
cccg                                                                   54

<210>  210
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NY-ESO-1 CDR3  TCR alpha

<400>  210
Cys Ala Val Arg Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe 
1               5                   10                  15  




<210>  211
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NY-ESO-1 CDR3 TCR beta

<400>  211
Cys Ala Ser Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe 
1               5                   10                  

<210>  212
<211>  469
<212>  PRT
<213>  Artificial sequence

<220>
<223>  EGFR.BB.Z

<400>  212
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser 
1               5                   10                  15  

Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
                20                  25                  30  

Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
                35                  40                  45  

Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn 
                50                  55                  60  

Thr Pro Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys 
                65                  70                  75  

Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr 
                80                  85                  90  

Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu 
                95                  100                 105 

Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly 
                110                 115                 120 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                125                 130                 135 

Gly Gly Gly Ser Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu 
                140                 145                 150 

Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala Ser 
                155                 160                 165 

Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr Asn 
                170                 175                 180 

Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser 
                185                 190                 195 

Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                200                 205                 210 

Thr Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr 
                215                 220                 225 

Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly 
                230                 235                 240 

Thr Lys Leu Glu Leu Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255 

Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                260                 265                 270 

Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                275                 280                 285 

Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                290                 295                 300 

Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                305                 310                 315 

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
                320                 325                 330 

Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                335                 340                 345 

Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
                350                 355                 360 

Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                365                 370                 375 

Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                380                 385                 390 

Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                395                 400                 405 

Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                410                 415                 420 

Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                425                 430                 435 

Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                440                 445                 450 

Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                455                 460                 465 

Leu Pro Pro Arg 
                

<210>  213
<211>  486
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD19.28.z

<400>  213
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15  

Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
                20                  25                  30  

Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
                35                  40                  45  

Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
                50                  55                  60  

Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                65                  70                  75  

Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
                80                  85                  90  

Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                95                  100                 105 

Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
                110                 115                 120 

Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                125                 130                 135 

Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                140                 145                 150 

Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro 
                155                 160                 165 

Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
                170                 175                 180 

Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
                185                 190                 195 

Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 
                200                 205                 210 

Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr 
                215                 220                 225 

Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
                230                 235                 240 

Val Thr Val Ser Ser Ala Ala Ala Gly Thr Thr Thr Thr Pro Ala 
                245                 250                 255 

Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                260                 265                 270 

Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                275                 280                 285 

His Thr Arg Gly Leu Asp Phe Ala Cys Asp Arg Arg Pro Pro Ser 
                290                 295                 300 

Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
                305                 310                 315 

Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
                320                 325                 330 

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                335                 340                 345 

Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                350                 355                 360 

Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ala Ser Leu Arg Val 
                365                 370                 375 

Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                380                 385                 390 

Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                395                 400                 405 

Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                410                 415                 420 

Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                425                 430                 435 

Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                440                 445                 450 

Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                455                 460                 465 

Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                470                 475                 480 

Gln Ala Leu Pro Pro Arg 
                485     

<210>  214
<211>  271
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MUC1 TRA

<400>  214
Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln 
1               5                   10                  15  

Trp Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu 
                20                  25                  30  

Ser Val Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr 
                35                  40                  45  

Asp Ser Ala Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly 
                50                  55                  60  

Lys Gly Leu Thr Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu 
                65                  70                  75  

Gln Thr Ser Gly Arg Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly 
                80                  85                  90  

Arg Ser Thr Leu Tyr Ile Ala Ala Ser Gln Pro Gly Asp Ser Ala 
                95                  100                 105 

Thr Tyr Leu Cys Ala Val Thr Ser Ser Tyr Gly Lys Leu Thr Phe 
                110                 115                 120 

Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile Gln Asn Pro 
                125                 130                 135 

Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys 
                140                 145                 150 

Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Ser Val Ser 
                155                 160                 165 

Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu 
                170                 175                 180 

Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                185                 190                 195 

Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
                200                 205                 210 

Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                215                 220                 225 

Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
                230                 235                 240 

Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255 

Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
                260                 265                 270 

Ser 
    

<210>  215
<211>  309
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MUC1 TRB

<400>  215
Met Ala Thr Arg Leu Leu Cys Cys Val Val Leu Cys Leu Leu Gly 
1               5                   10                  15  

Glu Glu Leu Ile Asp Ala Arg Val Thr Gln Thr Pro Arg His Lys 
                20                  25                  30  

Val Thr Glu Met Gly Gln Glu Val Thr Met Arg Cys Gln Pro Ile 
                35                  40                  45  

Leu Gly His Asn Thr Val Phe Trp Tyr Arg Gln Thr Met Met Gln 
                50                  55                  60  

Gly Leu Glu Leu Leu Ala Tyr Phe Arg Asn Arg Ala Pro Leu Asp 
                65                  70                  75  

Asp Ser Gly Met Pro Lys Asp Arg Phe Ser Ala Glu Met Pro Asp 
                80                  85                  90  

Ala Thr Leu Ala Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp 
                95                  100                 105 

Ser Ala Val Tyr Phe Cys Ala Ser Gly Leu Gly Glu Gly Arg Gly 
                110                 115                 120 

Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val Val Glu Asp Leu 
                125                 130                 135 

Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu 
                140                 145                 150 

Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
                155                 160                 165 

Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
                170                 175                 180 

Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu 
                185                 190                 195 

Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
                200                 205                 210 

Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
                215                 220                 225 

Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
                230                 235                 240 

Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255 

Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr 
                260                 265                 270 

Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
                275                 280                 285 

Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu 
                290                 295                 300 

Met Ala Met Val Lys Arg Lys Asp Phe 
                305                 

<210>  216
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MUC1 TRA CDR3

<400>  216
Cys Ala Val Thr Ser Ser Tyr Gly Lys Leu Thr Phe 
1               5                   10          

<210>  217
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MUC1 TRB CDR3

<400>  217
Cys Ala Ser Gly Leu Gly Glu Gly Arg Gly Tyr Thr Phe 
1               5                   10              

<210>  218
<211>  271
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MAGE-A4 TRA

<400>  218
Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln 
1               5                   10                  15  

Trp Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu 
                20                  25                  30  

Ser Val Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr 
                35                  40                  45  

Asp Ser Ala Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly 
                50                  55                  60  

Lys Gly Leu Thr Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu 
                65                  70                  75  

Gln Thr Ser Gly Arg Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly 
                80                  85                  90  

Arg Ser Thr Leu Tyr Ile Ala Ala Ser Gln Pro Gly Asp Ser Ala 
                95                  100                 105 

Thr Tyr Leu Cys Ala Val Gly Gly Tyr Ser Thr Leu Thr Phe Gly 
                110                 115                 120 

Lys Gly Thr Val Leu Leu Val Ser Pro Asp Asn Ile Gln Asn Pro 
                125                 130                 135 

Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys 
                140                 145                 150 

Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser 
                155                 160                 165 

Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu 
                170                 175                 180 

Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                185                 190                 195 

Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
                200                 205                 210 

Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                215                 220                 225 

Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
                230                 235                 240 

Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255 

Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
                260                 265                 270 

Ser 
    

<210>  219
<211>  308
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MAGE-A4 TRB

<400>  219
Met Ser Ile Ser Leu Leu Cys Cys Ala Ala Phe Pro Leu Leu Trp 
1               5                   10                  15  

Ala Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg 
                20                  25                  30  

Ile Leu Lys Ile Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp 
                35                  40                  45  

Met Asn His Asn Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met 
                50                  55                  60  

Gly Leu Lys Leu Ile Tyr Tyr Ser Val Gly Ala Gly Ile Thr Asp 
                65                  70                  75  

Lys Gly Glu Val Pro Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr 
                80                  85                  90  

Glu Asp Phe Pro Leu Arg Leu Glu Leu Ala Ala Pro Ser Gln Thr 
                95                  100                 105 

Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ser Arg Trp Ser Pro Leu 
                110                 115                 120 

His Phe Gly Asn Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Asn 
                125                 130                 135 

Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala 
                140                 145                 150 

Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr 
                155                 160                 165 

Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
                170                 175                 180 

Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
                185                 190                 195 

Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg 
                200                 205                 210 

Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
                215                 220                 225 

Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
                230                 235                 240 

Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255 

Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln 
                260                 265                 270 

Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
                275                 280                 285 

Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
                290                 295                 300 

Ala Met Val Lys Arg Lys Asp Phe 
                305             

<210>  220
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAGE-A4 TRA CDR3

<400>  220
Cys Ala Val Gly Gly Tyr Ser Thr Leu Thr Phe 
1               5                   10      

<210>  221
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAGE-A4 TRB CDR3

<400>  221
Cys Ala Ser Ser Tyr Ser Arg Trp Ser Pro Leu His Phe 
1               5                   10              

<210>  222
<211>  331
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NKG2D.z

<400>  222
Met Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
1               5                   10                  15  

Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                20                  25                  30  

Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                35                  40                  45  

Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                50                  55                  60  

Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                65                  70                  75  

Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                80                  85                  90  

Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                95                  100                 105 

Leu His Met Gln Ala Leu Pro Pro Arg Glu Phe Gly Trp Ile Arg 
                110                 115                 120 

Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser Glu Phe His Asn 
                125                 130                 135 

Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr Arg Trp Gln 
                140                 145                 150 

Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu Asn Ala 
                155                 160                 165 

Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly Ile 
                170                 175                 180 

Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn 
                185                 190                 195 

Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
                200                 205                 210 

Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys 
                215                 220                 225 

Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
                230                 235                 240 

Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
                245                 250                 255 

Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met 
                260                 265                 270 

Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp 
                275                 280                 285 

Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln 
                290                 295                 300 

Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile 
                305                 310                 315 

Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr 
                320                 325                 330 

Val 
    



