                         SEQUENCE LISTING

<110>  Numab Therapeutics AG
 
<120>  MULTISPECIFIC ANTIBODIES HAVING SPECIFICITY FOR IL-4R AND IL-31

<130>  117032P877PC

<150>  EP20216957:9
<151>  2020-12-23

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  1

Gly Phe Ser Ser Ser Ser Ala His Tyr Met Cys 
1               5                   10      


<210>  2
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  2

Cys Ile Tyr Ala Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  3
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  3

Arg Ala Ala Phe Val Asn Arg Gly Val Ser Trp Ile Trp Pro Tyr Tyr 
1               5                   10                  15      


Phe Ser Leu 
            


<210>  4
<211>  129
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser Ser Ala 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Ala Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ala Ala Phe Val Asn Arg Gly Val Ser Trp Ile Trp 
            100                 105                 110         


Pro Tyr Tyr Phe Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  5
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser Ser Ala 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Ala Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Ala Phe Val Asn Arg Gly Val Ser Trp Ile Trp Pro 
            100                 105                 110         


Tyr Tyr Phe Ser Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  6
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser Ser Ala 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Ala Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Ala Phe Val Asn Arg Gly Val Ser Trp Ile Trp Pro 
            100                 105                 110         


Tyr Tyr Phe Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  7
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  7

Gln Ala Ser Glu Asp Ile Glu Ser Tyr Leu Ala 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  8

Arg Ala Ser Thr Leu Ala Tyr 
1               5           


<210>  9
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  9

Leu Gly Ser Ser Tyr Ser Thr Gly Ser Asn Ile 
1               5                   10      


<210>  10
<211>  99
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Tyr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Ser Tyr Ser Thr Gly 
                85                  90                  95      


Ser Asn Ile 
            


<210>  11
<211>  99
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Tyr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Ser Tyr Ser Thr Gly 
                85                  90                  95      


Ser Asn Ile 
            


<210>  12
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  12

Gly Phe Ser Phe Ser Ala Asn Tyr Trp Ile Cys 
1               5                   10      


<210>  13
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  13

Cys Ile Tyr Ile Gly Ser Arg Ala Asp Thr Tyr Tyr Ala Pro Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  14
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  14

Arg Phe Ser Ser Gly Ile Tyr Asp Leu Asp Arg Phe Phe Leu 
1               5                   10                  


<210>  15
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  15

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Val Cys Ile Tyr Ile Gly Ser Arg Ala Asp Thr Tyr Tyr Ala Pro 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Phe Ser Ser Gly Ile Tyr Asp Leu Asp Arg Phe Phe 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  16
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  16

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Val Cys Ile Tyr Ile Gly Ser Arg Ala Asp Thr Tyr Tyr Ala Pro 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Phe Ser Ser Gly Ile Tyr Asp Leu Asp Arg Phe Phe 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  17
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  17

Gln Ala Ser Gln Ser Ile Asp Ser Trp Leu Ala 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  18

Gln Ala Ser Gln Ser Ile Glu Ser Trp Leu Ala 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  19

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  20
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  20

Gln Thr Tyr Tyr Gly Gly Gly His Ile Gly Trp Gly 
1               5                   10          


<210>  21
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  21

Ala Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Gly Gly Gly His 
                85                  90                  95      


Ile Gly Trp Gly 
            100 


<210>  22
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  22

Ala Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Glu Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Gly Gly Gly His 
                85                  90                  95      


Ile Gly Trp Gly 
            100 


<210>  23
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Tyr Pro Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Gly Gly Ser Ser Asp Ile Thr Tyr Asp Ala Asn 
    50                  55                  60                  


Trp Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Ala Trp Tyr Ser Gly Trp Gly Gly Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  24
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Lys Val Ser Gly Phe Ser Phe Ser Asn Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Thr Phe Val Gly Ser Ser Asp Ser Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln 
65                  70                  75                  80  


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Pro Ser Asp Ala Val Tyr Gly Tyr Ala Asn Asn 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  25
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Tyr Gly Asn Tyr Gly 
                85                  90                  95      


Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105             


<210>  26
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  26

Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  27

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
1               5                   10      


<210>  28
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  28

Phe Gly Gly Gly Thr Gln Leu Ile Ile Leu Gly 
1               5                   10      


<210>  29
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  29

Phe Gly Glu Gly Thr Glu Leu Thr Val Leu Gly 
1               5                   10      


<210>  30
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  30

Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  31

Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  32

Phe Gly Gly Gly Thr Gln Leu Thr Ala Leu Gly 
1               5                   10      


<210>  33
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  33

Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  34
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  34

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  35
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  35

Gly Gly Gly Gly Ser 
1               5   


<210>  36
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  36

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  37
<211>  216
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Tyr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Ser Tyr Ser Thr Gly 
                85                  90                  95      


Ser Asn Ile Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  38
<211>  720
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser Ser Ala 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Ala Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ala Ala Phe Val Asn Arg Gly Val Ser Trp Ile Trp 
            100                 105                 110         


Pro Tyr Tyr Phe Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
    130                 135                 140                 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
        195                 200                 205             


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                325                 330                 335     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Ala Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
465                 470                 475                 480 


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Ser 
                485                 490                 495     


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu 
            500                 505                 510         


Ile Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
        515                 520                 525             


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
    530                 535                 540                 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Gly Gly Gly 
545                 550                 555                 560 


His Ile Gly Trp Gly Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
                565                 570                 575     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val 
        595                 600                 605             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
    610                 615                 620                 


Phe Ser Ala Asn Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys 
625                 630                 635                 640 


Gly Leu Glu Trp Ile Val Cys Ile Tyr Ile Gly Ser Arg Ala Asp Thr 
                645                 650                 655     


Tyr Tyr Ala Pro Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn 
            660                 665                 670         


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        675                 680                 685             


Thr Ala Thr Tyr Phe Cys Ala Arg Phe Ser Ser Gly Ile Tyr Asp Leu 
    690                 695                 700                 


Asp Arg Phe Phe Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
705                 710                 715                 720 


<210>  39
<211>  216
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Tyr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Ser Tyr Ser Thr Gly 
                85                  90                  95      


Ser Asn Ile Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  40
<211>  719
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser Ser Ala 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Ala Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Ala Phe Val Asn Arg Gly Val Ser Trp Ile Trp Pro 
            100                 105                 110         


Tyr Tyr Phe Ser Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Ala Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
465                 470                 475                 480 


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Ser Trp 
                485                 490                 495     


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
            500                 505                 510         


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
        515                 520                 525             


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    530                 535                 540                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Gly Gly Gly His 
545                 550                 555                 560 


Ile Gly Trp Gly Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
                565                 570                 575     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln 
        595                 600                 605             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe 
    610                 615                 620                 


Ser Ala Asn Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly 
625                 630                 635                 640 


Leu Glu Trp Ile Val Cys Ile Tyr Ile Gly Ser Arg Ala Asp Thr Tyr 
                645                 650                 655     


Tyr Ala Pro Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser 
            660                 665                 670         


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        675                 680                 685             


Ala Thr Tyr Phe Cys Ala Arg Phe Ser Ser Gly Ile Tyr Asp Leu Asp 
    690                 695                 700                 


Arg Phe Phe Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
705                 710                 715                 


<210>  41
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  41

Ala Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Gly Gly Gly His 
                85                  90                  95      


Ile Gly Trp Gly Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  42
<211>  719
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  42

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Val Cys Ile Tyr Ile Gly Ser Arg Ala Asp Thr Tyr Tyr Ala Pro 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Phe Ser Ser Gly Ile Tyr Asp Leu Asp Arg Phe Phe 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    450                 455                 460                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly Asp Arg Val Thr 
465                 470                 475                 480 


Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr Leu Ala Trp Tyr 
                485                 490                 495     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser 
            500                 505                 510         


Thr Leu Ala Tyr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        515                 520                 525             


Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    530                 535                 540                 


Thr Tyr Tyr Cys Leu Gly Ser Ser Tyr Ser Thr Gly Ser Asn Ile Phe 
545                 550                 555                 560 


Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
            580                 585                 590         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        595                 600                 605             


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser Ser Ala His Tyr 
    610                 615                 620                 


Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
625                 630                 635                 640 


Cys Ile Tyr Ala Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
                645                 650                 655     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
            660                 665                 670         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        675                 680                 685             


Ala Arg Ala Ala Phe Val Asn Arg Gly Val Ser Trp Ile Trp Pro Tyr 
    690                 695                 700                 


Tyr Phe Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
705                 710                 715                 


<210>  43
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  43

Ala Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Gly Gly Gly His 
                85                  90                  95      


Ile Gly Trp Gly Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  44
<211>  718
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  44

Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ala Asn 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Val Cys Ile Tyr Ile Gly Ser Arg Ala Asp Thr Tyr Tyr Ala Pro 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Phe Ser Ser Gly Ile Tyr Asp Leu Asp Arg Phe Phe 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    450                 455                 460                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
465                 470                 475                 480 


Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr Leu Ala Trp Tyr 
                485                 490                 495     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser 
            500                 505                 510         


Thr Leu Ala Tyr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        515                 520                 525             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    530                 535                 540                 


Thr Tyr Tyr Cys Leu Gly Ser Ser Tyr Ser Thr Gly Ser Asn Ile Phe 
545                 550                 555                 560 


Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
            580                 585                 590         


Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly Ser Leu 
        595                 600                 605             


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser Ser Ala His Tyr 
    610                 615                 620                 


Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
625                 630                 635                 640 


Cys Ile Tyr Ala Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
                645                 650                 655     


Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val Tyr Leu 
            660                 665                 670         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
        675                 680                 685             


Arg Ala Ala Phe Val Asn Arg Gly Val Ser Trp Ile Trp Pro Tyr Tyr 
    690                 695                 700                 


Phe Ser Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
705                 710                 715             


<210>  45
<211>  481
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Tyr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Ser Tyr Ser Thr Gly 
                85                  90                  95      


Ser Asn Ile Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Ala Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
225                 230                 235                 240 


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp 
                245                 250                 255     


Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
            260                 265                 270         


Leu Ile Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
        275                 280                 285             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
    290                 295                 300                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Gly Gly 
305                 310                 315                 320 


Gly His Ile Gly Trp Gly Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
                325                 330                 335     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg 
        355                 360                 365             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    370                 375                 380                 


Ser Phe Ser Ala Asn Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly 
385                 390                 395                 400 


Lys Gly Leu Glu Trp Ile Val Cys Ile Tyr Ile Gly Ser Arg Ala Asp 
                405                 410                 415     


Thr Tyr Tyr Ala Pro Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp 
            420                 425                 430         


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        435                 440                 445             


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Ser Ser Gly Ile Tyr Asp 
    450                 455                 460                 


Leu Asp Arg Phe Phe Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
465                 470                 475                 480 


Ser 
    


<210>  46
<211>  455
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser Ser Ala 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Ala Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ala Ala Phe Val Asn Arg Gly Val Ser Trp Ile Trp 
            100                 105                 110         


Pro Tyr Tyr Phe Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
    130                 135                 140                 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
        195                 200                 205             


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                325                 330                 335     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Leu Gly 
    450                 455 


<210>  47
<211>  481
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Tyr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Ser Tyr Ser Thr Gly 
                85                  90                  95      


Ser Asn Ile Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Ala Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
225                 230                 235                 240 


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp 
                245                 250                 255     


Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
            260                 265                 270         


Leu Ile Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
        275                 280                 285             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
    290                 295                 300                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Gly Gly 
305                 310                 315                 320 


Gly His Ile Gly Trp Gly Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
                325                 330                 335     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg 
        355                 360                 365             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    370                 375                 380                 


Ser Phe Ser Ala Asn Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly 
385                 390                 395                 400 


Lys Gly Leu Glu Trp Ile Val Cys Ile Tyr Ile Gly Ser Arg Ala Asp 
                405                 410                 415     


Thr Tyr Tyr Ala Pro Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp 
            420                 425                 430         


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        435                 440                 445             


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Ser Ser Gly Ile Tyr Asp 
    450                 455                 460                 


Leu Asp Arg Phe Phe Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
465                 470                 475                 480 


Ser 
    


<210>  48
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser Ser Ala 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Ala Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Ala Phe Val Asn Arg Gly Val Ser Trp Ile Trp Pro 
            100                 105                 110         


Tyr Tyr Phe Ser Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly 
    450                 


<210>  49
<211>  481
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Tyr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Ser Tyr Ser Thr Gly 
                85                  90                  95      


Ser Asn Ile Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Ala Phe Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
225                 230                 235                 240 


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp 
                245                 250                 255     


Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 
            260                 265                 270         


Leu Ile Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
        275                 280                 285             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
    290                 295                 300                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Gly Gly 
305                 310                 315                 320 


Gly His Ile Gly Trp Gly Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
                325                 330                 335     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gln Ser Gln Leu Val Glu Ser Gly Gly Gly Arg 
        355                 360                 365             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    370                 375                 380                 


Ser Phe Ser Ala Asn Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly 
385                 390                 395                 400 


Lys Gly Leu Glu Trp Ile Val Cys Ile Tyr Ile Gly Ser Arg Ala Asp 
                405                 410                 415     


Thr Tyr Tyr Ala Pro Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp 
            420                 425                 430         


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        435                 440                 445             


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Phe Ser Ser Gly Ile Tyr Asp 
    450                 455                 460                 


Leu Asp Arg Phe Phe Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
465                 470                 475                 480 


Ser 
    


<210>  50
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  artificial antibody-related sequence

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser Ser Ala 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Ala Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Ala Phe Val Asn Arg Gly Val Ser Trp Ile Trp Pro 
            100                 105                 110         


Tyr Tyr Phe Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly 
    450                 


