               SEQUENCE LISTING

<110> Boehringer Ingelheim International GmbH

<120> VIRAL CAPSID PROTEINS WITH SPECIFICITY TO PRIMATE HEART TISSUE

<130> P 112920

<160> 37

<170> BiSSAP 1.3.6

<210> 1
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide 1

<400> 1
Asn Arg Gly Thr Glu Trp Asp 
1               5           

<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide 2

<400> 2
Gly His Gly Tyr Phe 
1               5   

<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide 3

<400> 3
Glu Ser Gly His Gly Tyr Phe 
1               5           

<210> 4
<211> 735
<212> PRT
<213> Adeno-associated virus - 2


<220> 
<223> VP1 protein

<400> 4
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         
Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             
Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 
Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 
His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     
Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         
Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             
Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 
Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 
Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 

<210> 5
<211> 598
<212> PRT
<213> Adeno-associated virus - 2


<220> 
<223> VP2 protein

<400> 5
Met Ala Pro Gly Lys Lys Arg Pro Val Glu His Ser Pro Val Glu Pro 
1               5                   10                  15      
Asp Ser Ser Ser Gly Thr Gly Lys Ala Gly Gln Gln Pro Ala Arg Lys 
            20                  25                  30          
Arg Leu Asn Phe Gly Gln Thr Gly Asp Ala Asp Ser Val Pro Asp Pro 
        35                  40                  45              
Gln Pro Leu Gly Gln Pro Pro Ala Ala Pro Ser Gly Leu Gly Thr Asn 
    50                  55                  60                  
Thr Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly 
65                  70                  75                  80  
Ala Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr 
                85                  90                  95      
Trp Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
            100                 105                 110         
Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly 
        115                 120                 125             
Ala Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
    130                 135                 140                 
Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
145                 150                 155                 160 
Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe 
                165                 170                 175     
Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr 
            180                 185                 190         
Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
        195                 200                 205             
Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys 
    210                 215                 220                 
Leu Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
225                 230                 235                 240 
Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr 
                245                 250                 255     
Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe 
            260                 265                 270         
Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala 
        275                 280                 285             
His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr 
    290                 295                 300                 
Leu Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln 
305                 310                 315                 320 
Ser Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln 
                325                 330                 335     
Ser Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser 
            340                 345                 350         
Lys Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala 
        355                 360                 365             
Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro 
    370                 375                 380                 
Ala Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser 
385                 390                 395                 400 
Gly Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp 
                405                 410                 415     
Ile Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn 
            420                 425                 430         
Pro Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg 
        435                 440                 445             
Gly Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu 
    450                 455                 460                 
Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
465                 470                 475                 480 
Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
                485                 490                 495     
Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
            500                 505                 510         
Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys 
        515                 520                 525             
Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
    530                 535                 540                 
Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
545                 550                 555                 560 
Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr 
                565                 570                 575     
Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
            580                 585                 590         
Tyr Leu Thr Arg Asn Leu 
        595             

<210> 6
<211> 533
<212> PRT
<213> Adeno-associated virus - 2


<220> 
<223> VP3 protein

<400> 6
Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      
Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          
Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              
Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala 
    50                  55                  60                  
Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe 
65                  70                  75                  80  
Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
                85                  90                  95      
Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys 
            100                 105                 110         
Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr 
        115                 120                 125             
Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser 
    130                 135                 140                 
Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu 
145                 150                 155                 160 
Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu 
                165                 170                 175     
Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys 
            180                 185                 190         
Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr 
        195                 200                 205             
Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His 
    210                 215                 220                 
Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu 
225                 230                 235                 240 
Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser 
                245                 250                 255     
Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser 
            260                 265                 270         
Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys 
        275                 280                 285             
Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr 
    290                 295                 300                 
Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala 
305                 310                 315                 320 
Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly 
                325                 330                 335     
Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile 
            340                 345                 350         
Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro 
        355                 360                 365             
Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly 
    370                 375                 380                 
Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro 
385                 390                 395                 400 
Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
                405                 410                 415     
Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met 
            420                 425                 430         
Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn 
        435                 440                 445             
Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe 
    450                 455                 460                 
Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile 
465                 470                 475                 480 
Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
                485                 490                 495     
Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val 
            500                 505                 510         
Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr 
        515                 520                 525             
Leu Thr Arg Asn Leu 
    530             

<210> 7
<211> 744
<212> PRT
<213> Adeno-associated virus - 2


<220> 
<223> VP1 modified with peptide 1

<400> 7
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Gln Arg Gly Asn Arg Gly 
            580                 585                 590         
Thr Glu Trp Asp Ala Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly 
        595                 600                 605             
Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly 
    610                 615                 620                 
Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser 
625                 630                 635                 640 
Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
                645                 650                 655     
Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala 
            660                 665                 670         
Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
        675                 680                 685             
Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
    690                 695                 700                 
Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp 
705                 710                 715                 720 
Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly 
                725                 730                 735     
Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 

<210> 8
<211> 744
<212> PRT
<213> Adeno-associated virus - 2


<220> 
<223> VP1 modified with peptide 3

<400> 8
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Gln Arg Gly Glu Ser Gly 
            580                 585                 590         
His Gly Tyr Phe Ala Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly 
        595                 600                 605             
Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly 
    610                 615                 620                 
Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser 
625                 630                 635                 640 
Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
                645                 650                 655     
Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala 
            660                 665                 670         
Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
        675                 680                 685             
Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
    690                 695                 700                 
Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp 
705                 710                 715                 720 
Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly 
                725                 730                 735     
Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 

<210> 9
<211> 8359
<212> DNA
<213> Artificial Sequence


<220> 
<223> cap/rep plasmid modified with insert coding for peptide 1

<400> 9
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt       60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagctct agaggtcctg      120

tattagaggt cacgtgagtg ttttgcgaca ttttgcgaca ccatgtggtc acgctgggta      180

tttaagcccg agtgagcacg cagggtctcc attttgaagc gggaggtttg aacgcgcagc      240

cgccatgccg gggttttacg agattgtgat taaggtcccc agcgaccttg acgagcatct      300

gcccggcatt tctgacagct ttgtgaactg ggtggccgag aaggaatggg agttgccgcc      360

agattctgac atggatctga atctgattga gcaggcaccc ctgaccgtgg ccgagaagct      420

gcagcgcgac tttctgacgg aatggcgccg tgtgagtaag gcaccggagg cccttttctt      480

tgtgcaattt gagaagggag agagctactt ccacatgcac gtgctcgtgg aaaccaccgg      540

ggtgaaatcc atggttttgg gacgtttcct gagtcagatt cgcgaaaaac tgattcagag      600

aatttaccgc gggatcgagc cgactttgcc aaactggttc gcggtcacaa agaccagaaa      660

tggcgccgga ggcgggaaca aggtggtgga tgagtgctac atccccaatt acttgctccc      720

caaaacccag cctgagctcc agtgggcgtg gactaatatg gaacagtatt taagcgcctg      780

tttgaatctc acggagcgta aacggttggt ggcgcagcat ctgacgcacg tgtcgcagac      840

gcaggagcag aacaaagaga atcagaatcc caattctgat gcgccggtga tcagatcaaa      900

aacttcagcc aggtacatgg agctggtcgg gtggctcgtg gacaagggga ttacctcgga      960

gaagcagtgg atccaggagg accaggcctc atacatctcc ttcaatgcgg cctccaactc     1020

gcggtcccaa atcaaggctg ccttggacaa tgcgggaaag attatgagcc tgactaaaac     1080

cgcccccgac tacctggtgg gccagcagcc cgtggaggac atttccagca atcggattta     1140

taaaattttg gaactaaacg ggtacgatcc ccaatatgcg gcttccgtct ttctgggatg     1200

ggccacgaaa aagttcggca agaggaacac catctggctg tttgggcctg caactaccgg     1260

gaagaccaac atcgcggagg ccatagccca cactgtgccc ttctacgggt gcgtaaactg     1320

gaccaatgag aactttccct tcaacgactg tgtcgacaag atggtgatct ggtgggagga     1380

ggggaagatg accgccaagg tcgtggagtc ggccaaagcc attctcggag gaagcaaggt     1440

gcgcgtggac cagaaatgca agtcctcggc ccagatagac ccgactcccg tgatcgtcac     1500

ctccaacacc aacatgtgcg ccgtgattga cgggaactca acgaccttcg aacaccagca     1560

gccgttgcaa gaccggatgt tcaaatttga actcacccgc cgtctggatc atgactttgg     1620

gaaggtcacc aagcaggaag tcaaagactt tttccggtgg gcaaaggatc acgtggttga     1680

ggtggagcat gaattctacg tcaaaaaggg tggagccaag aaaagacccg cccccagtga     1740

cgcagatata agtgagccca aacgggtgcg cgagtcagtt gcgcagccat cgacgtcaga     1800

cgcggaagct tcgatcaact acgcagacag gtaccaaaac aaatgttctc gtcacgtggg     1860

catgaatctg atgctgtttc cctgcagaca atgcgagaga atgaatcaga attcaaatat     1920

ctgcttcact cacggacaga aagactgttt agagtgcttt cccgtgtcag aatctcaacc     1980

cgtttctgtc gtcaaaaagg cgtatcagaa actgtgctac attcatcata tcatgggaaa     2040

ggtgccagac gcttgcactg cctgcgatct ggtcaatgtg gatttggatg actgcatctt     2100

tgaacaataa atgatttaaa tcaggtatgg ctgccgatgg ttatcttcca gattggctcg     2160

aggacactct ctctgaagga ataagacagt ggtggaagct caaacctggc ccaccaccac     2220

caaagcccgc agagcggcat aaggacgaca gcaggggtct tgtgcttcct gggtacaagt     2280

acctcggacc cttcaacgga ctcgacaagg gagagccggt caacgaggca gacgccgcgg     2340

ccctcgagca cgacaaagcc tacgaccggc agctcgacag cggagacaac ccgtacctca     2400

agtacaacca cgccgacgcg gagtttcagg agcgccttaa agaagatacg tcttttgggg     2460

gcaacctcgg acgagcagtc ttccaggcga aaaagagggt tcttgaacct ctgggcctgg     2520

ttgaggaacc tgttaagacg gctccgggaa aaaagaggcc ggtagagcac tctcctgtgg     2580

agccagactc ctcctcggga accggaaagg cgggccagca gcctgcaaga aaaagattga     2640

attttggtca gactggagac gcagactcag tacctgaccc ccagcctctc ggacagccac     2700

cagcagcccc ctctggtctg ggaactaata cgatggctac aggcagtggc gcaccaatgg     2760

cagacaataa cgagggcgcc gacggagtgg gtaattcctc gggaaattgg cattgcgatt     2820

ccacatggat gggcgacaga gtcatcacca ccagcacccg aacctgggcc ctgcccacct     2880

acaacaacca cctctacaaa caaatttcca gccaatcagg agcctcgaac gacaatcact     2940

actttggcta cagcacccct tgggggtatt ttgacttcaa cagattccac tgccactttt     3000

caccacgtga ctggcaaaga ctcatcaaca acaactgggg attccgaccc aagagactca     3060

acttcaagct ctttaacatt caagtcaaag aggtcacgca gaatgacggt acgacgacga     3120

ttgccaataa ccttaccagc acggttcagg tgtttactga ctcggagtac cagctcccgt     3180

acgtcctcgg ctcggcgcat caaggatgcc tcccgccgtt cccagcagac gtcttcatgg     3240

tgccacagta tggatacctc accctgaaca acgggagtca ggcagtagga cgctcttcat     3300

tttactgcct ggagtacttt ccttctcaga tgctgcgtac cggaaacaac tttaccttca     3360

gctacacttt tgaggacgtt cctttccaca gcagctacgc tcacagccag agtctggacc     3420

gtctcatgaa tcctctcatc gaccagtacc tgtattactt gagcagaaca aacactccaa     3480

gtggaaccac cacgcagtca aggcttcagt tttctcaggc cggagcgagt gacattcggg     3540

accagtctag gaactggctt cctggaccct gttaccgcca gcagcgagta tcaaagacat     3600

ctgcggataa caacaacagt gaatactcgt ggactggagc taccaagtac cacctcaatg     3660

gcagagactc tctggtgaat ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa     3720

agttttttcc tcagagcggg gttctcatct ttgggaagca aggctcagag aaaacaaatg     3780

tggacattga aaaggtcatg attacagacg aagaggaaat caggacaacc aatcccgtgg     3840

ctacggagca gtatggttct gtatctacca acctccagag aggccagaga ggcaatcggg     3900

ggactgagtg ggatgcccag gcggccaccg cagatgtcaa cacacaaggc gttcttccag     3960

gcatggtctg gcaggacaga gatgtgtacc ttcaggggcc catctgggca aagattccac     4020

acacggacgg acattttcac ccctctcccc tcatgggtgg attcggactt aaacaccctc     4080

ctccacagat tctcatcaag aacaccccgg tacctgcgaa tccttcgacc accttcagtg     4140

cggcaaagtt tgcttccttc atcacacagt actccacggg acaggtcagc gtggagatcg     4200

agtgggagct gcagaaggaa aacagcaaac gctggaatcc cgaaattcag tacacttcca     4260

actacaacaa gtctgttaat gtggacttta ctgtggacac taatggcgtg tattcagagc     4320

ctcgccccat tggcaccaga tacctgactc gtaatctgta attgcttgtt aatcaataaa     4380

ccgtttaatt cgtttcagtt gaactttggt ctctgcgtat ttctttctta tctagtttcc     4440

atgctctaga ggtcctgtat tagaggtcac gtgagtgttt tgcgacattt tgcgacacca     4500

tgtggtcacg ctgggtattt aagcccgagt gagcacgcag ggtctccatt ttgaagcggg     4560

aggtttgaac gcgcagccac cacggcgggg ttttacgaga ttgtgattaa ggtccccagc     4620

gaccttgacg agcatctgcc cggcatttct gacagctttg tgaactgggt ggccgagaag     4680

gaatgggagt tgccgccaga ttctgacatg gatctgaatc tgattgagca ggcacccctg     4740

accgtggccg agaagctgca tcgctggcgt aatagcgaag aggcccgcac cgatcgccct     4800

tcccaacagt tgcgcagcct gaatggcgaa tggcgattcc gttgcaatgg ctggcggtaa     4860

tattgttctg gatattacca gcaaggccga tagtttgagt tcttctactc aggcaagtga     4920

tgttattact aatcaaagaa gtattgcgac aacggttaat ttgcgtgatg gacagactct     4980

tttactcggt ggcctcactg attataaaaa cacttctcag gattctggcg taccgttcct     5040

gtctaaaatc cctttaatcg gcctcctgtt tagctcccgc tctgattcta acgaggaaag     5100

cacgttatac gtgctcgtca aagcaaccat agtacgcgcc ctgtagcggc gcattaagcg     5160

cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg     5220

ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc     5280

taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa     5340

aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc     5400

ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac     5460

tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt     5520

ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgt     5580

ttacaattta aatatttgct tatacaatct tcctgttttt ggggcttttc tgattatcaa     5640

ccggggtaca tatgattgac atgctagttt tacgattacc gttcatcgat tctcttgttt     5700

gctccagact ctcaggcaat gacctgatag cctttgtaga gacctctcaa aaatagctac     5760

cctctccggc atgaatttat cagctagaac ggttgaatat catattgatg gtgatttgac     5820

tgtctccggc ctttctcacc cgtttgaatc tttacctaca cattactcag gcattgcatt     5880

taaaatatat gagggttcta aaaattttta tccttgcgtt gaaataaagg cttctcccgc     5940

aaaagtatta cagggtcata atgtttttgg tacaaccgat ttagctttat gctctgaggc     6000

tttattgctt aattttgcta attctttgcc ttgcctgtat gatttattgg atgttggaat     6060

tcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atatggtgca     6120

ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac     6180

ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga     6240

ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac     6300

gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt     6360

agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct     6420

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat     6480

attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg     6540

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg     6600

aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc     6660

ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat     6720

gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact     6780

attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca     6840

tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact     6900

tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg     6960

atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg     7020

agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg     7080

aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg     7140

caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag     7200

ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc     7260

gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga     7320

tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat     7380

atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc     7440

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag     7500

accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct     7560

gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac     7620

caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc     7680

tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg     7740

ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt     7800

tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt     7860

gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc     7920

tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca     7980

gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata     8040

gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg     8100

ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct     8160

ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta     8220

ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag     8280

tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga     8340

ttcattaatg cagaattcc                                                  8359


<210> 10
<211> 8359
<212> DNA
<213> Artificial Sequence


<220> 
<223> cap/rep plasmid modified with insert coding for peptide 3

<400> 10
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt       60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagctct agaggtcctg      120

tattagaggt cacgtgagtg ttttgcgaca ttttgcgaca ccatgtggtc acgctgggta      180

tttaagcccg agtgagcacg cagggtctcc attttgaagc gggaggtttg aacgcgcagc      240

cgccatgccg gggttttacg agattgtgat taaggtcccc agcgaccttg acgagcatct      300

gcccggcatt tctgacagct ttgtgaactg ggtggccgag aaggaatggg agttgccgcc      360

agattctgac atggatctga atctgattga gcaggcaccc ctgaccgtgg ccgagaagct      420

gcagcgcgac tttctgacgg aatggcgccg tgtgagtaag gcaccggagg cccttttctt      480

tgtgcaattt gagaagggag agagctactt ccacatgcac gtgctcgtgg aaaccaccgg      540

ggtgaaatcc atggttttgg gacgtttcct gagtcagatt cgcgaaaaac tgattcagag      600

aatttaccgc gggatcgagc cgactttgcc aaactggttc gcggtcacaa agaccagaaa      660

tggcgccgga ggcgggaaca aggtggtgga tgagtgctac atccccaatt acttgctccc      720

caaaacccag cctgagctcc agtgggcgtg gactaatatg gaacagtatt taagcgcctg      780

tttgaatctc acggagcgta aacggttggt ggcgcagcat ctgacgcacg tgtcgcagac      840

gcaggagcag aacaaagaga atcagaatcc caattctgat gcgccggtga tcagatcaaa      900

aacttcagcc aggtacatgg agctggtcgg gtggctcgtg gacaagggga ttacctcgga      960

gaagcagtgg atccaggagg accaggcctc atacatctcc ttcaatgcgg cctccaactc     1020

gcggtcccaa atcaaggctg ccttggacaa tgcgggaaag attatgagcc tgactaaaac     1080

cgcccccgac tacctggtgg gccagcagcc cgtggaggac atttccagca atcggattta     1140

taaaattttg gaactaaacg ggtacgatcc ccaatatgcg gcttccgtct ttctgggatg     1200

ggccacgaaa aagttcggca agaggaacac catctggctg tttgggcctg caactaccgg     1260

gaagaccaac atcgcggagg ccatagccca cactgtgccc ttctacgggt gcgtaaactg     1320

gaccaatgag aactttccct tcaacgactg tgtcgacaag atggtgatct ggtgggagga     1380

ggggaagatg accgccaagg tcgtggagtc ggccaaagcc attctcggag gaagcaaggt     1440

gcgcgtggac cagaaatgca agtcctcggc ccagatagac ccgactcccg tgatcgtcac     1500

ctccaacacc aacatgtgcg ccgtgattga cgggaactca acgaccttcg aacaccagca     1560

gccgttgcaa gaccggatgt tcaaatttga actcacccgc cgtctggatc atgactttgg     1620

gaaggtcacc aagcaggaag tcaaagactt tttccggtgg gcaaaggatc acgtggttga     1680

ggtggagcat gaattctacg tcaaaaaggg tggagccaag aaaagacccg cccccagtga     1740

cgcagatata agtgagccca aacgggtgcg cgagtcagtt gcgcagccat cgacgtcaga     1800

cgcggaagct tcgatcaact acgcagacag gtaccaaaac aaatgttctc gtcacgtggg     1860

catgaatctg atgctgtttc cctgcagaca atgcgagaga atgaatcaga attcaaatat     1920

ctgcttcact cacggacaga aagactgttt agagtgcttt cccgtgtcag aatctcaacc     1980

cgtttctgtc gtcaaaaagg cgtatcagaa actgtgctac attcatcata tcatgggaaa     2040

ggtgccagac gcttgcactg cctgcgatct ggtcaatgtg gatttggatg actgcatctt     2100

tgaacaataa atgatttaaa tcaggtatgg ctgccgatgg ttatcttcca gattggctcg     2160

aggacactct ctctgaagga ataagacagt ggtggaagct caaacctggc ccaccaccac     2220

caaagcccgc agagcggcat aaggacgaca gcaggggtct tgtgcttcct gggtacaagt     2280

acctcggacc cttcaacgga ctcgacaagg gagagccggt caacgaggca gacgccgcgg     2340

ccctcgagca cgacaaagcc tacgaccggc agctcgacag cggagacaac ccgtacctca     2400

agtacaacca cgccgacgcg gagtttcagg agcgccttaa agaagatacg tcttttgggg     2460

gcaacctcgg acgagcagtc ttccaggcga aaaagagggt tcttgaacct ctgggcctgg     2520

ttgaggaacc tgttaagacg gctccgggaa aaaagaggcc ggtagagcac tctcctgtgg     2580

agccagactc ctcctcggga accggaaagg cgggccagca gcctgcaaga aaaagattga     2640

attttggtca gactggagac gcagactcag tacctgaccc ccagcctctc ggacagccac     2700

cagcagcccc ctctggtctg ggaactaata cgatggctac aggcagtggc gcaccaatgg     2760

cagacaataa cgagggcgcc gacggagtgg gtaattcctc gggaaattgg cattgcgatt     2820

ccacatggat gggcgacaga gtcatcacca ccagcacccg aacctgggcc ctgcccacct     2880

acaacaacca cctctacaaa caaatttcca gccaatcagg agcctcgaac gacaatcact     2940

actttggcta cagcacccct tgggggtatt ttgacttcaa cagattccac tgccactttt     3000

caccacgtga ctggcaaaga ctcatcaaca acaactgggg attccgaccc aagagactca     3060

acttcaagct ctttaacatt caagtcaaag aggtcacgca gaatgacggt acgacgacga     3120

ttgccaataa ccttaccagc acggttcagg tgtttactga ctcggagtac cagctcccgt     3180

acgtcctcgg ctcggcgcat caaggatgcc tcccgccgtt cccagcagac gtcttcatgg     3240

tgccacagta tggatacctc accctgaaca acgggagtca ggcagtagga cgctcttcat     3300

tttactgcct ggagtacttt ccttctcaga tgctgcgtac cggaaacaac tttaccttca     3360

gctacacttt tgaggacgtt cctttccaca gcagctacgc tcacagccag agtctggacc     3420

gtctcatgaa tcctctcatc gaccagtacc tgtattactt gagcagaaca aacactccaa     3480

gtggaaccac cacgcagtca aggcttcagt tttctcaggc cggagcgagt gacattcggg     3540

accagtctag gaactggctt cctggaccct gttaccgcca gcagcgagta tcaaagacat     3600

ctgcggataa caacaacagt gaatactcgt ggactggagc taccaagtac cacctcaatg     3660

gcagagactc tctggtgaat ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa     3720

agttttttcc tcagagcggg gttctcatct ttgggaagca aggctcagag aaaacaaatg     3780

tggacattga aaaggtcatg attacagacg aagaggaaat caggacaacc aatcccgtgg     3840

ctacggagca gtatggttct gtatctacca acctccagag aggccagaga ggcgagtctg     3900

gtcatggtta ttttgcccag gcggccaccg cagatgtcaa cacacaaggc gttcttccag     3960

gcatggtctg gcaggacaga gatgtgtacc ttcaggggcc catctgggca aagattccac     4020

acacggacgg acattttcac ccctctcccc tcatgggtgg attcggactt aaacaccctc     4080

ctccacagat tctcatcaag aacaccccgg tacctgcgaa tccttcgacc accttcagtg     4140

cggcaaagtt tgcttccttc atcacacagt actccacggg acaggtcagc gtggagatcg     4200

agtgggagct gcagaaggaa aacagcaaac gctggaatcc cgaaattcag tacacttcca     4260

actacaacaa gtctgttaat gtggacttta ctgtggacac taatggcgtg tattcagagc     4320

ctcgccccat tggcaccaga tacctgactc gtaatctgta attgcttgtt aatcaataaa     4380

ccgtttaatt cgtttcagtt gaactttggt ctctgcgtat ttctttctta tctagtttcc     4440

atgctctaga ggtcctgtat tagaggtcac gtgagtgttt tgcgacattt tgcgacacca     4500

tgtggtcacg ctgggtattt aagcccgagt gagcacgcag ggtctccatt ttgaagcggg     4560

aggtttgaac gcgcagccac cacggcgggg ttttacgaga ttgtgattaa ggtccccagc     4620

gaccttgacg agcatctgcc cggcatttct gacagctttg tgaactgggt ggccgagaag     4680

gaatgggagt tgccgccaga ttctgacatg gatctgaatc tgattgagca ggcacccctg     4740

accgtggccg agaagctgca tcgctggcgt aatagcgaag aggcccgcac cgatcgccct     4800

tcccaacagt tgcgcagcct gaatggcgaa tggcgattcc gttgcaatgg ctggcggtaa     4860

tattgttctg gatattacca gcaaggccga tagtttgagt tcttctactc aggcaagtga     4920

tgttattact aatcaaagaa gtattgcgac aacggttaat ttgcgtgatg gacagactct     4980

tttactcggt ggcctcactg attataaaaa cacttctcag gattctggcg taccgttcct     5040

gtctaaaatc cctttaatcg gcctcctgtt tagctcccgc tctgattcta acgaggaaag     5100

cacgttatac gtgctcgtca aagcaaccat agtacgcgcc ctgtagcggc gcattaagcg     5160

cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg     5220

ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc     5280

taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa     5340

aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc     5400

ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac     5460

tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt     5520

ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgt     5580

ttacaattta aatatttgct tatacaatct tcctgttttt ggggcttttc tgattatcaa     5640

ccggggtaca tatgattgac atgctagttt tacgattacc gttcatcgat tctcttgttt     5700

gctccagact ctcaggcaat gacctgatag cctttgtaga gacctctcaa aaatagctac     5760

cctctccggc atgaatttat cagctagaac ggttgaatat catattgatg gtgatttgac     5820

tgtctccggc ctttctcacc cgtttgaatc tttacctaca cattactcag gcattgcatt     5880

taaaatatat gagggttcta aaaattttta tccttgcgtt gaaataaagg cttctcccgc     5940

aaaagtatta cagggtcata atgtttttgg tacaaccgat ttagctttat gctctgaggc     6000

tttattgctt aattttgcta attctttgcc ttgcctgtat gatttattgg atgttggaat     6060

tcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atatggtgca     6120

ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac     6180

ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga     6240

ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac     6300

gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt     6360

agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct     6420

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat     6480

attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg     6540

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg     6600

aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc     6660

ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat     6720

gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact     6780

attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca     6840

tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact     6900

tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg     6960

atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg     7020

agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg     7080

aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg     7140

caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag     7200

ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc     7260

gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga     7320

tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat     7380

atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc     7440

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag     7500

accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct     7560

gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac     7620

caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc     7680

tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg     7740

ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt     7800

tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt     7860

gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc     7920

tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca     7980

gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata     8040

gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg     8100

ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct     8160

ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta     8220

ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag     8280

tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga     8340

ttcattaatg cagaattcc                                                  8359


<210> 11
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer forward

<400> 11
cgtcaatggg tggagtattt acg                                            23


<210> 12
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer reverse

<400> 12
aggtcatgta ctgggcataa tgc                                            23


<210> 13
<211> 34
<212> DNA
<213> Artificial Sequence


<220> 
<223> Probe

<400> 13
agtacatcaa gtgtatcata tgccaagtac gccc                                 34


<210> 14
<211> 1617
<212> DNA
<213> Artificial Sequence


<220> 
<223> CAG-Promoter

<400> 14
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca     120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc     180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta     240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattaa     300

catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc cctccccacc     360

cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg cggggggggg     420

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag     480

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg     540

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcgggagtcg ctgcgcgctg     600

ccttcgcccc gtgccccgct ccgccgccgc ctcgcgccgc ccgccccggc tctgactgac     660

cgcgttactc ccacaggtga gcgggcggga cggcccttct cctccgggct gtaattagcg     720

cttggtttaa tgacggcttg tttcttttct gtggctgcgt gaaagccttg aggggctccg     780

ggagggccct ttgtgcgggg ggagcggctc ggggggtgcg tgcgtgtgtg tgtgcgtggg     840

gagcgccgcg tgcggctccg cgctgcccgg cggctgtgag cgctgcgggc gcggcgcggg     900

gctttgtgcg ctccgcagtg tgcgcgaggg gagcgcggcc gggggcggtg ccccgcggtg     960

cggggggggc tgcgagggga acaaaggctg cgtgcggggt gtgtgcgtgg gggggtgagc    1020

agggggtgtg ggcgcgtcgg tcgggctgca accccccctg cacccccctc cccgagttgc    1080

tgagcacggc ccggcttcgg gtgcggggct ccgtacgggg cgtggcgcgg ggctcgccgt    1140

gccgggcggg gggtggcggc aggtgggggt gccgggcggg gcggggccgc ctcgggccgg    1200

ggagggctcg ggggaggggc gcggcggccc ccggagcgcc ggcggctgtc gaggcgcggc    1260

gagccgcagc cattgccttt tatggtaatc gtgcgagagg gcgcagggac ttcctttgtc    1320

ccaaatctgt gcggagccga aatctgggag gcgccgccgc accccctcta gcgggcgcgg    1380

ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg gagggccttc gtgcgtcgcc    1440

gcgccgccgt ccccttctcc ctctccagcc tcggggctgt ccgcgggggg acggctgcct    1500

tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg gctctagaca    1560

attgtactaa ccttcttctc tttcctctcc tgacaggttg gtgtacagta gcttcca       1617


<210> 15
<211> 221
<212> DNA
<213> Simian virus 40


<220> 
<223> polyadenylation sequence

<400> 15
cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa     60

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca    120

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt    180

gggaggtttt ttaaagcaag taaaacctct acaaatgtgg t                        221


<210> 16
<211> 140
<212> DNA
<213> Adeno-associated virus - 2


<220> 
<223> ITR

<400> 16
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaccg cccgggcgtc     60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca    120

actccatcac taggggttcc                                                140


<210> 17
<211> 140
<212> DNA
<213> Adeno-associated virus - 2


<220> 
<223> ITR

<400> 17
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc    120

gagcgcgcag ctgcctgcag                                                140


<210> 18
<211> 173
<212> PRT
<213> Homo sapiens


<220> 
<223> huMydgf protein sequence with signal peptide

<400> 18
Met Ala Ala Pro Ser Gly Gly Trp Asn Gly Val Gly Ala Ser Leu Trp 
1               5                   10                  15      
Ala Ala Leu Leu Leu Gly Ala Val Ala Leu Arg Pro Ala Glu Ala Val 
            20                  25                  30          
Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly Val Val 
        35                  40                  45              
His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr Cys Met 
    50                  55                  60                  
Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met Ser 
65                  70                  75                  80  
Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile Trp Arg 
                85                  90                  95      
Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu Val 
            100                 105                 110         
Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala Phe 
        115                 120                 125             
Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu Val Thr 
    130                 135                 140                 
Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys Ala Glu Leu Ser 
145                 150                 155                 160 
Lys Leu Val Ile Val Ala Lys Ala Ser Arg Thr Glu Leu 
                165                 170             

<210> 19
<211> 522
<212> DNA
<213> Homo sapiens


<220> 
<223> huMydgf gene sequence

<400> 19
atggcggcgc ccagcggagg gtggaacggc gtcggcgcga gcttgtgggc cgcgctgctc      60

ctaggggccg tggcgctgag gccggcggag gcggtgtccg agcccacgac ggtggcgttt     120

gacgtgcggc ccggcggcgt cgtgcattcc ttctcccata acgtgggccc gggggacaaa     180

tatacgtgta tgttcactta cgcctctcaa ggagggacca atgagcaatg gcagatgagt     240

ctggggacca gcgaagacca ccagcacttc acctgcacca tctggaggcc ccaggggaag     300

tcctatctgt acttcacaca gttcaaggca gaggtgcggg gcgctgagat tgagtacgct     360

atggcctact ctaaagccgc atttgaaagg gaaagtgatg tccctctgaa aactgaggaa     420

tttgaagtga ccaaaacagc agtggctcac aggcccgggg cattcaaagc tgagctgtcc     480

aagctggtga ttgtggccaa ggcatcgcgc actgagctgt ga                        522


<210> 20
<211> 169
<212> PRT
<213> Artificial Sequence


<220> 
<223> mutant huMydgf protein sequence with signal peptide

<400> 20
Met Ala Ala Pro Ser Gly Gly Trp Asn Gly Val Gly Ala Ser Leu Trp 
1               5                   10                  15      
Ala Ala Leu Leu Leu Gly Ala Val Ala Leu Arg Pro Ala Glu Ala Val 
            20                  25                  30          
Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly Val Val 
        35                  40                  45              
His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr Cys Met 
    50                  55                  60                  
Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met Ser 
65                  70                  75                  80  
Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile Trp Arg 
                85                  90                  95      
Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu Val 
            100                 105                 110         
Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala Phe 
        115                 120                 125             
Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu Val Thr 
    130                 135                 140                 
Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys Ala Glu Leu Ser 
145                 150                 155                 160 
Lys Leu Val Ile Val Ala Lys Ala Ser 
                165                 

<210> 21
<211> 510
<212> DNA
<213> Artificial Sequence


<220> 
<223> mutant huMydgf gene sequence

<400> 21
atggcggcgc ccagcggagg gtggaacggc gtcggcgcga gcttgtgggc cgcgctgctc      60

ctaggggccg tggcgctgag gccggcggag gcggtgtccg agcccacgac ggtggcgttt     120

gacgtgcggc ccggcggcgt cgtgcattcc ttctcccata acgtgggccc gggggacaaa     180

tatacgtgta tgttcactta cgcctctcaa ggagggacca atgagcaatg gcagatgagt     240

ctggggacca gcgaagacca ccagcacttc acctgcacca tctggaggcc ccaggggaag     300

tcctatctgt acttcacaca gttcaaggca gaggtgcggg gcgctgagat tgagtacgct     360

atggcctact ctaaagccgc atttgaaagg gaaagtgatg tccctctgaa aactgaggaa     420

tttgaagtga ccaaaacagc agtggctcac aggcccgggg cattcaaagc tgagctgtcc     480

aagctggtga ttgtggccaa ggcatcgtga                                      510


<210> 22
<211> 2757
<212> DNA
<213> Artificial Sequence


<220> 
<223> pAAV plasmids harbouring huMydgf

<400> 22
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaccg cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggcccga taggctggac tctgcaccat aacacacaat     180

caacagggga gtgagctgga tcgagctaga gtccgttaca taacttacgg taaatggccc     240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat     300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc     360

ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga     420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg     480

gcagtacatc tacgtattag tcatcgctat taacatggtc gaggtgagcc ccacgttctg     540

cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat ttatttttta     600

attattttgt gcagcgatgg gggcgggggg gggggggggg cgcgcgccag gcggggcggg     660

gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg     720

cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct ataaaaagcg     780

aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc gctccgccgc     840

cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg tgagcgggcg     900

ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc ttgtttcttt     960

tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg gggggagcgg    1020

ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc    1080

cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga    1140

ggggagcgcg gccgggggcg gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg    1200

ctgcgtgcgg ggtgtgtgcg tgggggggtg agcagggggt gtgggcgcgt cggtcgggct    1260

gcaacccccc ctgcaccccc ctccccgagt tgctgagcac ggcccggctt cgggtgcggg    1320

gctccgtacg gggcgtggcg cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg    1380

ggtgccgggc ggggcggggc cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg    1440

cccccggagc gccggcggct gtcgaggcgc ggcgagccgc agccattgcc ttttatggta    1500

atcgtgcgag agggcgcagg gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg    1560

gaggcgccgc cgcaccccct ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa    1620

ggaaatgggc ggggagggcc ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca    1680

gcctcggggc tgtccgcggg gggacggctg ccttcggggg ggacggggca gggcggggtt    1740

cggcttctgg cgtgtgaccg gcggctctag acaattgtac taaccttctt ctctttcctc    1800

tcctgacagg ttggtgtaca gtagcttcca ccatggcggc gcccagcgga gggtggaacg    1860

gcgtcggcgc gagcttgtgg gccgcgctgc tcctaggggc cgtggcgctg aggccggcgg    1920

aggcggtgtc cgagcccacg acggtggcgt ttgacgtgcg gcccggcggc gtcgtgcatt    1980

ccttctccca taacgtgggc ccgggggaca aatatacgtg tatgttcact tacgcctctc    2040

aaggagggac caatgagcaa tggcagatga gtctggggac cagcgaagac caccagcact    2100

tcacctgcac catctggagg ccccagggga agtcctatct gtacttcaca cagttcaagg    2160

cagaggtgcg gggcgctgag attgagtacg ctatggccta ctctaaagcc gcatttgaaa    2220

gggaaagtga tgtccctctg aaaactgagg aatttgaagt gaccaaaaca gcagtggctc    2280

acaggcccgg ggcattcaaa gctgagctgt ccaagctggt gattgtggcc aaggcatcgc    2340

gcactgagct gtgaaagctt gcctcgaggc cggccgcttc gagcagacat gataagatac    2400

attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa    2460

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac    2520

aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc    2580

aagtaaaacc tctacaaatg tggtaaaatc gggccgcagg aacccctagt gatggagttg    2640

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga    2700

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg cctgcag       2757


<210> 23
<211> 2745
<212> DNA
<213> Artificial Sequence


<220> 
<223> pAAV plasmids harbouring huMydgf-RTEL

<400> 23
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaccg cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggcccga taggctggac tctgcaccat aacacacaat     180

caacagggga gtgagctgga tcgagctaga gtccgttaca taacttacgg taaatggccc     240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat     300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc     360

ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga     420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg     480

gcagtacatc tacgtattag tcatcgctat taacatggtc gaggtgagcc ccacgttctg     540

cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat ttatttttta     600

attattttgt gcagcgatgg gggcgggggg gggggggggg cgcgcgccag gcggggcggg     660

gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg     720

cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct ataaaaagcg     780

aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc gctccgccgc     840

cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg tgagcgggcg     900

ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc ttgtttcttt     960

tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg gggggagcgg    1020

ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc    1080

cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga    1140

ggggagcgcg gccgggggcg gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg    1200

ctgcgtgcgg ggtgtgtgcg tgggggggtg agcagggggt gtgggcgcgt cggtcgggct    1260

gcaacccccc ctgcaccccc ctccccgagt tgctgagcac ggcccggctt cgggtgcggg    1320

gctccgtacg gggcgtggcg cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg    1380

ggtgccgggc ggggcggggc cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg    1440

cccccggagc gccggcggct gtcgaggcgc ggcgagccgc agccattgcc ttttatggta    1500

atcgtgcgag agggcgcagg gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg    1560

gaggcgccgc cgcaccccct ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa    1620

ggaaatgggc ggggagggcc ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca    1680

gcctcggggc tgtccgcggg gggacggctg ccttcggggg ggacggggca gggcggggtt    1740

cggcttctgg cgtgtgaccg gcggctctag acaattgtac taaccttctt ctctttcctc    1800

tcctgacagg ttggtgtaca gtagcttcca ccatggcggc gcccagcgga gggtggaacg    1860

gcgtcggcgc gagcttgtgg gccgcgctgc tcctaggggc cgtggcgctg aggccggcgg    1920

aggcggtgtc cgagcccacg acggtggcgt ttgacgtgcg gcccggcggc gtcgtgcatt    1980

ccttctccca taacgtgggc ccgggggaca aatatacgtg tatgttcact tacgcctctc    2040

aaggagggac caatgagcaa tggcagatga gtctggggac cagcgaagac caccagcact    2100

tcacctgcac catctggagg ccccagggga agtcctatct gtacttcaca cagttcaagg    2160

cagaggtgcg gggcgctgag attgagtacg ctatggccta ctctaaagcc gcatttgaaa    2220

gggaaagtga tgtccctctg aaaactgagg aatttgaagt gaccaaaaca gcagtggctc    2280

acaggcccgg ggcattcaaa gctgagctgt ccaagctggt gattgtggcc aaggcatcgt    2340

gaaagcttgc ctcgaggccg gccgcttcga gcagacatga taagatacat tgatgagttt    2400

ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct    2460

attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt    2520

cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc    2580

tacaaatgtg gtaaaatcgg gccgcaggaa cccctagtga tggagttggc cactccctct    2640

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt    2700

gcccgggcgg cctcagtgag cgagcgagcg cgcagctgcc tgcag                    2745


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide 1 with stuffer

<400> 24
Gly Asn Arg Gly Thr Glu Trp Asp Ala 
1               5                   

<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide 3 with stuffer

<400> 25
Gly Glu Ser Gly His Gly Tyr Phe Ala 
1               5                   

<210> 26
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide 1 with stuffer

<400> 26
Gln Arg Gly Asn Arg Gly Thr Glu Trp Asp Ala 
1               5                   10      

<210> 27
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide 3 with stuffer

<400> 27
Gln Arg Gly Glu Ser Gly His Gly Tyr Phe Ala 
1               5                   10      

<210> 28
<211> 1042
<212> PRT
<213> Homo sapiens


<220> 
<223> AT2A2 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 -
      Isoform 1

<400> 28
Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             
Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 
Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         
Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             
Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 
Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     
Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             
Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     
Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 
Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     
Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         
Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     
Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         
Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             
Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 
Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 
Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         
Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             
Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 
Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 
Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         
Pro Gly Lys Glu Cys Val Gln Pro Ala Thr Lys Ser Cys Ser Phe Ser 
        995                 1000                1005            
Ala Cys Thr Asp Gly Ile Ser Trp Pro Phe Val Leu Leu Ile Met Pro 
    1010                1015                1020                
Leu Val Ile Trp Val Tyr Ser Thr Asp Thr Asn Phe Ser Asp Met Phe 
1025                1030                1035                1040
Trp Ser 
        

<210> 29
<211> 997
<212> PRT
<213> Homo sapiens


<220> 
<223> AT2A2 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 -
      Isoform 2

<400> 29
Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             
Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 
Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         
Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             
Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 
Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     
Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             
Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     
Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 
Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     
Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         
Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     
Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         
Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             
Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 
Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 
Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         
Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             
Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 
Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 
Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         
Pro Ala Ile Leu Glu 
        995         

<210> 30
<211> 999
<212> PRT
<213> Homo sapiens


<220> 
<223> AT2A2 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 -
      Isoform 3

<400> 30
Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             
Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 
Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         
Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             
Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 
Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     
Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             
Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     
Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 
Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     
Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         
Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     
Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         
Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             
Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 
Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 
Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         
Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             
Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 
Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 
Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         
Pro Val Leu Ser Ser Glu Leu 
        995                 

<210> 31
<211> 1015
<212> PRT
<213> Homo sapiens


<220> 
<223> AT2A2 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 -
      Isoform 4

<400> 31
Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Gly Glu Ser Val Ser Val 
145                 150                 155                 160 
Ile Lys His Thr Asp Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp 
                165                 170                 175     
Lys Lys Asn Met Leu Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala 
            180                 185                 190         
Met Gly Val Val Val Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile 
        195                 200                 205             
Arg Asp Glu Met Val Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln 
    210                 215                 220                 
Lys Leu Asp Glu Phe Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile 
225                 230                 235                 240 
Cys Ile Ala Val Trp Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val 
                245                 250                 255     
His Gly Gly Ser Trp Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala 
            260                 265                 270         
Val Ala Leu Ala Val Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile 
        275                 280                 285             
Thr Thr Cys Leu Ala Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala 
    290                 295                 300                 
Ile Val Arg Ser Leu Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val 
305                 310                 315                 320 
Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val 
                325                 330                 335     
Cys Arg Met Phe Ile Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu 
            340                 345                 350         
Asn Glu Phe Thr Ile Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val 
        355                 360                 365             
His Lys Asp Asp Lys Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val 
    370                 375                 380                 
Glu Leu Ala Thr Ile Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr 
385                 390                 395                 400 
Asn Glu Ala Lys Gly Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr 
                405                 410                 415     
Ala Leu Thr Cys Leu Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu 
            420                 425                 430         
Lys Gly Leu Ser Lys Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile 
        435                 440                 445             
Lys Gln Leu Met Lys Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg 
    450                 455                 460                 
Lys Ser Met Ser Val Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser 
465                 470                 475                 480 
Met Ser Lys Met Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg 
                485                 490                 495     
Cys Thr His Ile Arg Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly 
            500                 505                 510         
Val Lys Gln Lys Ile Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser 
        515                 520                 525             
Asp Thr Leu Arg Cys Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg 
    530                 535                 540                 
Arg Glu Glu Met His Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu 
545                 550                 555                 560 
Thr Asn Leu Thr Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg 
                565                 570                 575     
Ile Glu Val Ala Ser Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg 
            580                 585                 590         
Val Ile Met Ile Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys 
        595                 600                 605             
Arg Arg Ile Gly Ile Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala 
    610                 615                 620                 
Phe Thr Gly Arg Glu Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp 
625                 630                 635                 640 
Ala Cys Leu Asn Ala Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys 
                645                 650                 655     
Ser Lys Ile Val Glu Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met 
            660                 665                 670         
Thr Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile 
        675                 680                 685             
Gly Ile Ala Met Gly Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu 
    690                 695                 700                 
Met Val Leu Ala Asp Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu 
705                 710                 715                 720 
Glu Gly Arg Ala Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu 
                725                 730                 735     
Ile Ser Ser Asn Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala 
            740                 745                 750         
Leu Gly Phe Pro Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn 
        755                 760                 765             
Leu Val Thr Asp Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro 
    770                 775                 780                 
Asp Leu Asp Ile Met Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu 
785                 790                 795                 800 
Ile Ser Gly Trp Leu Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val 
                805                 810                 815     
Gly Ala Ala Thr Val Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp 
            820                 825                 830         
Gly Gly Pro Arg Val Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys 
        835                 840                 845             
Lys Glu Asp Asn Pro Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu 
    850                 855                 860                 
Ser Pro Tyr Pro Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu 
865                 870                 875                 880 
Met Cys Asn Ala Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg 
                885                 890                 895     
Met Pro Pro Trp Glu Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser 
            900                 905                 910         
Met Ser Leu His Phe Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile 
        915                 920                 925             
Phe Gln Ile Thr Pro Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys 
    930                 935                 940                 
Ile Ser Leu Pro Val Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala 
945                 950                 955                 960 
Arg Asn Tyr Leu Glu Pro Gly Lys Glu Cys Val Gln Pro Ala Thr Lys 
                965                 970                 975     
Ser Cys Ser Phe Ser Ala Cys Thr Asp Gly Ile Ser Trp Pro Phe Val 
            980                 985                 990         
Leu Leu Ile Met Pro Leu Val Ile Trp Val Tyr Ser Thr Asp Thr Asn 
        995                 1000                1005            
Phe Ser Asp Met Phe Trp Ser 
    1010                1015

<210> 32
<211> 997
<212> PRT
<213> Homo sapiens


<220> 
<223> AT2A2 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 -
      Isoform 5

<400> 32
Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             
Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 
Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         
Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             
Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 
Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     
Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             
Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     
Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 
Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     
Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         
Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     
Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         
Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             
Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 
Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 
Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         
Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             
Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 
Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 
Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         
Pro Asp Ile Ile Lys 
        995         

<210> 33
<211> 142
<212> PRT
<213> Homo sapiens


<220> 
<223> human Mydgf without signal peptide (mature protein)

<400> 33
Val Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly Val 
1               5                   10                  15      
Val His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr Cys 
            20                  25                  30          
Met Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met 
        35                  40                  45              
Ser Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile Trp 
    50                  55                  60                  
Arg Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu 
65                  70                  75                  80  
Val Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala 
                85                  90                  95      
Phe Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu Val 
            100                 105                 110         
Thr Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys Ala Glu Leu 
        115                 120                 125             
Ser Lys Leu Val Ile Val Ala Lys Ala Ser Arg Thr Glu Leu 
    130                 135                 140         

<210> 34
<211> 138
<212> PRT
<213> Homo sapiens


<220> 
<223> human Mydgf without signal peptide without golgi retention signal
      (-RTEL)

<400> 34
Val Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly Val 
1               5                   10                  15      
Val His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr Cys 
            20                  25                  30          
Met Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met 
        35                  40                  45              
Ser Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile Trp 
    50                  55                  60                  
Arg Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu 
65                  70                  75                  80  
Val Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala 
                85                  90                  95      
Phe Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu Val 
            100                 105                 110         
Thr Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys Ala Glu Leu 
        115                 120                 125             
Ser Lys Leu Val Ile Val Ala Lys Ala Ser 
    130                 135             

<210> 35
<211> 143
<212> PRT
<213> Homo sapiens


<220> 
<223> Mydgf (WT) protein activity test probe compound protein sequence

<400> 35
Met Val Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly 
1               5                   10                  15      
Val Val His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr 
            20                  25                  30          
Cys Met Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln 
        35                  40                  45              
Met Ser Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile 
    50                  55                  60                  
Trp Arg Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala 
65                  70                  75                  80  
Glu Val Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala 
                85                  90                  95      
Ala Phe Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu 
            100                 105                 110         
Val Thr Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys Ala Glu 
        115                 120                 125             
Leu Ser Lys Leu Val Ile Val Ala Lys Ala Ser Arg Thr Glu Leu 
    130                 135                 140             

<210> 36
<211> 173
<212> PRT
<213> Homo sapiens


<220> 
<223> Mydgf-RTEL protein activity test probe compound pre-protein
      sequence with signal peptide

<400> 36
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      
Val Leu Ser His His His His His His Ala Gly Ser Glu Asn Leu Tyr 
            20                  25                  30          
Phe Gln Gly Val Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro 
        35                  40                  45              
Gly Gly Val Val His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys 
    50                  55                  60                  
Tyr Thr Cys Met Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln 
65                  70                  75                  80  
Trp Gln Met Ser Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys 
                85                  90                  95      
Thr Ile Trp Arg Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe 
            100                 105                 110         
Lys Ala Glu Val Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser 
        115                 120                 125             
Lys Ala Ala Phe Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu 
    130                 135                 140                 
Phe Glu Val Thr Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys 
145                 150                 155                 160 
Ala Glu Leu Ser Lys Leu Val Ile Val Ala Lys Ala Ser 
                165                 170             

<210> 37
<211> 154
<212> PRT
<213> Homo sapiens


<220> 
<223> Mydgf-RTEL protein activity test probe compound protein sequence
      without signal peptide

<400> 37
His His His His His His Ala Gly Ser Glu Asn Leu Tyr Phe Gln Gly 
1               5                   10                  15      
Val Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly Val 
            20                  25                  30          
Val His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr Cys 
        35                  40                  45              
Met Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met 
    50                  55                  60                  
Ser Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile Trp 
65                  70                  75                  80  
Arg Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu 
                85                  90                  95      
Val Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala 
            100                 105                 110         
Phe Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu Val 
        115                 120                 125             
Thr Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys Ala Glu Leu 
    130                 135                 140                 
Ser Lys Leu Val Ile Val Ala Lys Ala Ser 
145                 150                 

