                         SEQUENCE LISTING

<110>  VIVET THERAPEUTICS
 
<120>  MINIMAL BILE ACID INDUCIBLE PROMOTERS FOR GENE THERAPY

<130>  B2006397

<150>  EP20306684
<151>  2020-12-23

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  222
<212>  DNA
<213>  Artificial sequence

<220>
<223>  murine minimal bile acid inducible promoter

<400>  1
ggttcctgct ttgagtatgt tcgacctttc ctctcatgtc actgaactgt gctagatctg       60

gactttaggc cattgaccta taagcaaata gatagtgttc ttaaaaaagc ctgatttctg      120

ttcaatgctt tattaccatg aaaactgaac ttggaaaggg gtgtacaacc ctgactttcc      180

acagtggcgt ctctcgcttc tcctggctcc ctcaaattca ca                         222


<210>  2
<211>  231
<212>  DNA
<213>  Artificial sequence

<220>
<223>  human minimal bile acid inducible promoter

<400>  2
ttcccaagca cactctgtgt ttggggttat tgctctgagt atgtttctcg tatgtcactg       60

aactgtgctt gggctgccct tagggacatt gatccttagg caaatagata atgttcttga      120

aaaagtttga attctgttca gtgctttaga atgatgaaaa ccgaggttgg aaaaggttgt      180

gaaacctttt aactctccac agtggagtcc attatttcct ctggcttcct c               231


<210>  3
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  murine IR-1 element

<400>  3
ttaggccatt gaccta                                                       16


<210>  4
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IR-1-ER2 element

<400>  4
tggactttag gccattgacc ta                                                22


<210>  5
<211>  11
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LRHRE

<400>  5
tttctaaagc t                                                            11


<210>  6
<211>  238
<212>  DNA
<213>  Artificial sequence

<220>
<223>  imPR+1xIR

<400>  6
ttaggccatt gacctaggtt cctgctttga gtatgttcga cctttcctct catgtcactg       60

aactgtgcta gatctggact ttaggccatt gacctataag caaatagata gtgttcttaa      120

aaaagcctga tttctgttca atgctttatt accatgaaaa ctgaacttgg aaaggggtgt      180

acaaccctga ctttccacag tggcgtctct cgcttctcct ggctccctca aattcaca        238


<210>  7
<211>  270
<212>  DNA
<213>  Artificial sequence

<220>
<223>  imPR+3xIR

<400>  7
ttaggccatt gacctattag gccattgacc tattaggcca ttgacctagg ttcctgcttt       60

gagtatgttc gacctttcct ctcatgtcac tgaactgtgc tagatctgga ctttaggcca      120

ttgacctata agcaaataga tagtgttctt aaaaaagcct gatttctgtt caatgcttta      180

ttaccatgaa aactgaactt ggaaaggggt gtacaaccct gactttccac agtggcgtct      240

ctcgcttctc ctggctccct caaattcaca                                       270


<210>  8
<211>  3966
<212>  DNA
<213>  Artificial sequence

<220>
<223>  codon-optimized version of ABCB11 cDNA

<400>  8
atgagcgact ccgtgattct gagatcaatc aaaaaattcg gcgaagaaaa tgacgggttc       60

gagagcgata aatcctataa taatgacaag aagtctaggc tgcaggacga gaagaagggc      120

gatggcgtgc gggtgggctt ctttcagctg ttccggttca gcagcagcac cgacatctgg      180

ctgatgtttg tgggcagcct gtgcgccttc ctgcacggca tcgcacagcc aggcgtgctg      240

ctgatctttg gcaccatgac agacgtgttc atcgactacg atgtggagct gcaggagctg      300

cagatccctg gcaaagcctg cgtgaacaat accatcgtgt ggacaaacag ctccctgaac      360

cagaatatga ccaacggcac acgctgtggc ctgctgaata tcgagtctga gatgatcaag      420

tttgccagct actatgcagg aatcgcagtg gccgtgctga tcaccggcta catccagatt      480

tgcttctggg tcatcgcagc agcaaggcag atccagaaga tgagaaagtt ctattttcgg      540

agaatcatgc ggatggagat cggctggttt gactgtaact ctgtgggcga gctgaataca      600

agattcagcg acgacatcaa caagatcaat gacgccatcg ccgatcagat ggccctgttt      660

atccagcgga tgaccagcac aatctgtggc ttcctgctgg gcttctttag aggctggaag      720

ctgaccctgg tcatcatcag cgtgtcccca ctgatcggaa tcggagcagc aacaatcggc      780

ctgtctgtga gcaagttcac cgactacgag ctgaaagcct acgccaaggc aggagtggtg      840

gcagatgaag tgatcagcag catgaggacc gtggcagcct ttggcggaga gaagagggag      900

gtggagcggt acgagaagaa cctggtgttc gcccagcggt ggggcatcag aaagggcatc      960

gtgatgggct tctttacagg cttcgtgtgg tgcctgatct tcctgtgcta cgccctggcc     1020

ttttggtatg gctccaccct ggtgctggac gagggagagt atacccctgg cacactggtg     1080

cagattttcc tgagcgtgat cgtgggcgcc ctgaacctgg gaaatgcatc cccatgcctg     1140

gaagccttcg ccacaggaag ggcagcagcc acctccatct tcgagacaat cgaccgcaag     1200

cctatcatcg actgtatgtc tgaggatggc tacaagctgg acaggatcaa gggcgagatc     1260

gagtttcaca atgtgacctt ccactatccc agccgccctg aggtgaagat cctgaacgat     1320

ctgaatatgg tcatcaagcc aggagagatg accgccctgg tgggaccctc tggagcaggc     1380

aagagcaccg ccctgcagct gatccagcgg ttttacgacc cttgcgaggg aatggtgacc     1440

gtggacggac acgacatcag gtccctgaac atccagtggc tgcgcgatca gatcggcatc     1500

gtggagcagg agccagtgct gttctctacc acaatcgccg agaatatcag atacggccgc     1560

gaggatgcca caatggagga catcgtgcag gccgccaagg aggccaacgc ctataacttc     1620

atcatggatc tgccccagca gttcgacacc ctggtgggag agggaggagg acagatgtcc     1680

ggaggccaga agcagagagt ggccatcgcc agagccctga tccgcaaccc taagatcctg     1740

ctgctggata tggccacaag cgccctggac aatgagtccg aggctatggt gcaggaggtg     1800

ctgagcaaga tccagcacgg ccacaccatc atctctgtgg cacacaggct gagcacagtg     1860

agagcagccg acaccatcat cggctttgag cacggcacag cagtggagag gggcacccac     1920

gaggagctgc tggagaggaa gggcgtgtac ttcaccctgg tgacactgca gtcccagggc     1980

aaccaggccc tgaatgagga ggacatcaag gatgccacag aggacgatat gctggcccgg     2040

accttcagca gaggctccta tcaggattct ctgagggcca gcatcaggca gcggagcaag     2100

tctcagctga gctacctggt gcacgagcca cctctggcag tggtggacca caagtccacc     2160

tatgaggagg atcgcaagga caaggacatc ccagtgcagg aggaggtgga gcctgcacca     2220

gtgaggcgca tcctgaagtt ttccgcccca gagtggccct acatgctggt gggatctgtg     2280

ggagcagcag tgaacggcac cgtgacacca ctgtatgcct tcctgttttc ccagatcctg     2340

ggcaccttct ctatccccga caaggaggag cagcggtccc agatcaatgg cgtgtgcctg     2400

ctgtttgtgg ctatgggctg cgtgagcctg tttacacagt tcctgcaggg ctacgccttc     2460

gccaagagcg gcgagctgct gaccaagcgg ctgagaaagt tcggctttag agccatgctg     2520

ggccaggaca tcgcctggtt tgacgatctg cggaacagcc caggcgccct gaccacaaga     2580

ctggccacag atgcatctca ggtgcaggga gcagcaggca gccagatcgg catgatcgtg     2640

aactccttca ccaatgtgac agtggccatg atcatcgcct tcagcttttc ctggaagctg     2700

agcctggtca tcctgtgctt cttccccttt ctggccctga gcggagcaac ccagacaagg     2760

atgctgaccg gcttcgcctc cagagacaag caggccctgg agatggtggg ccagatcaca     2820

aacgaggccc tgagcaatat caggaccgtg gcaggaatcg gcaaggagcg gcggttcatc     2880

gaggccctgg agacagagct ggagaagcct ttcaagaccg ccatccagaa ggccaacatc     2940

tacggcttct gctttgcctt cgcccagtgt atcatgttca tcgccaactc tgccagctac     3000

cgctatggcg gctacctgat cagcaatgag ggcctgcact tcagctacgt gttcagagtg     3060

atcagcgccg tggtgctgtc tgccacagcc ctgggaaggg ccttctccta caccccatct     3120

tatgccaagg ccaagatcag cgccgccagg ttctttcagc tgctggaccg ccagccaccc     3180

atcagcgtgt acaacacagc cggcgagaag tgggataatt tccagggcaa gatcgacttt     3240

gtggattgca agttcaccta tcctagcaga ccagactccc aggtgctgaa tggcctgtcc     3300

gtgtctatca gcccaggcca gacactggcc tttgtgggct cctctggctg tggcaagtcc     3360

acctctatcc agctgctgga gcggttctat gaccccgatc agggcaaagt gatgatcgac     3420

ggccacgata gcaagaaggt gaacgtgcag tttctgagat ccaatatcgg catcgtgtct     3480

caggagcctg tgctgttcgc ctgctccatc atggataaca tcaagtacgg cgacaataca     3540

aaggagatcc caatggagag agtgatcgca gcagcaaagc aggcacagct gcacgatttc     3600

gtgatgtccc tgcccgagaa gtatgagaca aacgtgggct ctcagggcag ccagctgtcc     3660

aggggcgaga agcagaggat cgcaatcgcc agggccatcg tgcgcgatcc caagatcctg     3720

ctgctggacg aggccaccag cgccctggat acagagtccg agaagaccgt gcaggtggcc     3780

ctggacaagg cccgggaggg aagaacatgt atcgtgatcg cccacagact gagcaccatc     3840

cagaatgccg acatcatcgc cgtgatggcc cagggcgtgg tcatcgagaa gggcacccac     3900

gaggaactga tggcacagaa aggggcttac tacaaactgg tcacaacagg ctcacctatc     3960

tcatag                                                                3966


<210>  9
<211>  3840
<212>  DNA
<213>  artificial sequence

<220>
<223>  human codon-optimized version of ABCB4 cDNA

<400>  9
atggatctgg aggccgccaa gaacggcacc gcctggagac ccacaagcgc cgagggcgac       60

ttcgagctgg gcatcagctc caagcagaag agaaagaaga ccaagacagt gaagatgatc      120

ggcgtgctga cactgttcag gtactccgac tggcaggata agctgtttat gtctctgggc      180

accatcatgg caatcgccca cggcagcggc ctgcctctga tgatgatcgt gttcggcgag      240

atgaccgaca agtttgtgga tacagccggc aatttctcct ttcccgtgaa cttctctctg      300

agcctgctga accctggcaa gatcctggag gaggagatga caagatatgc ctactattac      360

tctggcctgg gagcaggcgt gctggtggca gcatacatcc aggtgagctt ctggaccctg      420

gcagcaggcc ggcagatcag aaagatcagg cagaagttct ttcacgccat cctgcgccag      480

gagatcggct ggtttgacat caatgatacc acagagctga acacccggct gacagacgac      540

atctctaaga tcagcgaggg catcggcgat aaagtgggca tgttctttca ggccgtggcc      600

acattctttg ccggcttcat cgtgggcttt atcaggggct ggaagctgac cctggtcatc      660

atggccatct ctccaatcct gggcctgagc gccgccgtgt gggcaaagat cctgtccgcc      720

ttctctgaca aggagctggc cgcctacgcc aaggcaggag cagtggcaga ggaggccctg      780

ggcgccatcc gcaccgtgat cgcctttggc ggccagaata aggagctgga gcggtatcag      840

aagcacctgg agaacgccaa ggagatcggc atcaagaagg ccatctccgc caatatctct      900

atgggcatcg ccttcctgct gatctatgcc agctacgccc tggccttttg gtatggcagc      960

accctggtca tcagcaagga gtacaccatc ggcaatgcca tgacagtgtt ctttagcatc     1020

ctgatcggag ccttctccgt gggacaggca gcaccatgca tcgacgcctt cgccaacgcc     1080

agaggcgcag cctacgtgat ctttgacatc atcgataaca atccaaagat cgactccttt     1140

tctgagcggg gccacaagcc cgattccatc aagggcaatc tggagttcaa cgacgtgcac     1200

tttagctatc cctcccgcgc caatgtgaag atcctgaagg gcctgaacct gaaggtgcag     1260

tccggacaga cagtggccct ggtgggctct agcggatgcg gcaagtctac cacagtgcag     1320

ctgatccagc ggctgtatga cccagatgag ggcaccatca acatcgacgg ccaggacatc     1380

cgcaacttca atgtgaacta cctgcgggag atcatcggcg tggtgtctca ggagcccgtg     1440

ctgtttagca ccacaatcgc cgagaatatc tgttatggcc gcggcaacgt gacaatggat     1500

gagatcaaga aggccgtgaa ggaggccaat gcctacgagt tcatcatgaa gctgccccag     1560

aagtttgaca ccctggtggg agagagaggc gcccagctga gcggaggcca gaagcagagg     1620

atcgccatcg ccagagccct ggtgaggaac cctaagatcc tgctgctgga cgaggccacc     1680

tccgccctgg atacagagtc tgaggcagag gtgcaggccg ccctggataa ggcccgcgag     1740

ggacggacca caatcgtgat cgcccacaga ctgagcacag tgaggaatgc cgacgtgatc     1800

gccggcttcg aggatggcgt gatcgtggag cagggcagcc actccgagct gatgaagaag     1860

gagggcgtgt acttcaagct ggtgaacatg cagacctctg gcagccagat ccagtccgag     1920

gagtttgagc tgaatgacga gaaggcagca acaaggatgg cacctaacgg atggaagagc     1980

agactgttca ggcactccac ccagaagaat ctgaagaact ctcagatgtg ccagaagagc     2040

ctggacgtgg aaaccgatgg actggaggca aatgtgccac ccgtgagctt cctgaaggtg     2100

ctgaagctga acaagacaga gtggccatat tttgtggtgg gcaccgtgtg cgcaatcgca     2160

aatggcggcc tgcagccagc cttcagcgtg atcttttccg agatcatcgc catcttcggc     2220

cctggcgacg atgccgtgaa gcagcagaag tgtaacatct tttccctgat cttcctgttt     2280

ctgggcatca tctctttctt taccttcttt ctgcagggct tcacatttgg caaggccggc     2340

gagatcctga cacggagact gagaagcatg gccttcaagg ccatgctgag gcaggatatg     2400

tcctggtttg acgatcacaa gaacagcacc ggcgccctgt ccaccagact ggcaacagac     2460

gcagcacagg tgcagggagc aaccggcaca aggctggccc tgatcgccca gaatatcgcc     2520

aacctgggca caggcatcat catctctttc atctacggct ggcagctgac cctgctgctg     2580

ctggcagtgg tgccaatcat cgccgtgagc ggcatcgtgg agatgaagct gctggccggc     2640

aatgccaaga gagacaagaa ggagctggag gcagcaggca agatcgcaac cgaggccatc     2700

gagaacatcc gcaccgtggt gagcctgaca caggagcgga agttcgagtc catgtatgtg     2760

gagaagctgt atggccctta ccgcaattcc gtgcagaagg cccacatcta cggcatcacc     2820

ttttccatct ctcaggcttt catgtatttt tcttacgccg gctgcttccg gtttggcgcc     2880

tatctgatcg tgaacggcca catgaggttc cgcgatgtga tcctggtgtt ctctgccatc     2940

gtgtttggag cagtggccct gggacacgcc tcctcttttg cccctgacta tgcaaaggca     3000

aagctgtccg ccgcacacct gttcatgctg tttgagagac agcctctgat cgatagctac     3060

tccgaggagg gcctgaagcc agacaagttc gagggcaata tcacattcaa cgaggtggtg     3120

tttaattatc caaccagggc caacgtgccc gtgctgcagg gcctgagcct ggaggtgaag     3180

aagggacaga cactggccct ggtgggcagc tccggatgcg gcaagtccac cgtggtgcag     3240

ctgctggaga gattctacga ccctctggca ggcaccgtgc tgctggatgg acaggaggcc     3300

aagaagctga atgtgcagtg gctgagagcc cagctgggca tcgtgtctca ggagccaatc     3360

ctgttcgatt gtagcatcgc cgagaatatc gcctacggcg acaactctag ggtggtgagc     3420

caggatgaga tcgtgagcgc cgcaaaggca gcaaacatcc acccttttat cgagaccctg     3480

ccacacaagt atgagacacg cgtgggcgac aagggcaccc agctgtccgg aggacagaag     3540

cagaggatcg caatcgcccg cgccctgatc aggcagcccc agatcctgct gctggatgaa     3600

gccacctccg ccctggacac agagtctgag aaggtggtgc aggaggccct ggacaaagcc     3660

cgcgagggac ggacatgtat tgtcattgct cacagactga gcaccatcca gaatgccgac     3720

ctgatcgtgg tgttccagaa cggcagggtg aaggagcacg gcacacacca gcagctgctg     3780

gcccagaagg gcatctactt ttctatggtg agcgtgcagg ccggcaccca gaacctgtag     3840


<210>  10
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polyA

<400>  10
aataaagacc tcttattttc attcatcagg tgtggttggt ttttttgtgt gggggc           56


<210>  11
<211>  130
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5'ITR AAV2

<400>  11
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  12
<211>  141
<212>  DNA
<213>  Artificial sequence

<220>
<223>  3'ITR AAV2

<400>  12
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  13
<211>  4606
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAV-imPr-hBSEPco

<400>  13
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcga attccatggt accggttcct gctttgagta tgttcgacct      180

ttcctctcat gtcactgaac tgtgctagat ctggacttta ggccattgac ctataagcaa      240

atagatagtg ttcttaaaaa agcctgattt ctgttcaatg ctttattacc atgaaaactg      300

aacttggaaa ggggtgtaca accctgactt tccacagtgg cgtctctcgc ttctcctggc      360

tccctcaaat tcacagagct cgccgccacc atgagcgact ccgtgattct gagatcaatc      420

aaaaaattcg gcgaagaaaa tgacgggttc gagagcgata aatcctataa taatgacaag      480

aagtctaggc tgcaggacga gaagaagggc gatggcgtgc gggtgggctt ctttcagctg      540

ttccggttca gcagcagcac cgacatctgg ctgatgtttg tgggcagcct gtgcgccttc      600

ctgcacggca tcgcacagcc aggcgtgctg ctgatctttg gcaccatgac agacgtgttc      660

atcgactacg atgtggagct gcaggagctg cagatccctg gcaaagcctg cgtgaacaat      720

accatcgtgt ggacaaacag ctccctgaac cagaatatga ccaacggcac acgctgtggc      780

ctgctgaata tcgagtctga gatgatcaag tttgccagct actatgcagg aatcgcagtg      840

gccgtgctga tcaccggcta catccagatt tgcttctggg tcatcgcagc agcaaggcag      900

atccagaaga tgagaaagtt ctattttcgg agaatcatgc ggatggagat cggctggttt      960

gactgtaact ctgtgggcga gctgaataca agattcagcg acgacatcaa caagatcaat     1020

gacgccatcg ccgatcagat ggccctgttt atccagcgga tgaccagcac aatctgtggc     1080

ttcctgctgg gcttctttag aggctggaag ctgaccctgg tcatcatcag cgtgtcccca     1140

ctgatcggaa tcggagcagc aacaatcggc ctgtctgtga gcaagttcac cgactacgag     1200

ctgaaagcct acgccaaggc aggagtggtg gcagatgaag tgatcagcag catgaggacc     1260

gtggcagcct ttggcggaga gaagagggag gtggagcggt acgagaagaa cctggtgttc     1320

gcccagcggt ggggcatcag aaagggcatc gtgatgggct tctttacagg cttcgtgtgg     1380

tgcctgatct tcctgtgcta cgccctggcc ttttggtatg gctccaccct ggtgctggac     1440

gagggagagt atacccctgg cacactggtg cagattttcc tgagcgtgat cgtgggcgcc     1500

ctgaacctgg gaaatgcatc cccatgcctg gaagccttcg ccacaggaag ggcagcagcc     1560

acctccatct tcgagacaat cgaccgcaag cctatcatcg actgtatgtc tgaggatggc     1620

tacaagctgg acaggatcaa gggcgagatc gagtttcaca atgtgacctt ccactatccc     1680

agccgccctg aggtgaagat cctgaacgat ctgaatatgg tcatcaagcc aggagagatg     1740

accgccctgg tgggaccctc tggagcaggc aagagcaccg ccctgcagct gatccagcgg     1800

ttttacgacc cttgcgaggg aatggtgacc gtggacggac acgacatcag gtccctgaac     1860

atccagtggc tgcgcgatca gatcggcatc gtggagcagg agccagtgct gttctctacc     1920

acaatcgccg agaatatcag atacggccgc gaggatgcca caatggagga catcgtgcag     1980

gccgccaagg aggccaacgc ctataacttc atcatggatc tgccccagca gttcgacacc     2040

ctggtgggag agggaggagg acagatgtcc ggaggccaga agcagagagt ggccatcgcc     2100

agagccctga tccgcaaccc taagatcctg ctgctggata tggccacaag cgccctggac     2160

aatgagtccg aggctatggt gcaggaggtg ctgagcaaga tccagcacgg ccacaccatc     2220

atctctgtgg cacacaggct gagcacagtg agagcagccg acaccatcat cggctttgag     2280

cacggcacag cagtggagag gggcacccac gaggagctgc tggagaggaa gggcgtgtac     2340

ttcaccctgg tgacactgca gtcccagggc aaccaggccc tgaatgagga ggacatcaag     2400

gatgccacag aggacgatat gctggcccgg accttcagca gaggctccta tcaggattct     2460

ctgagggcca gcatcaggca gcggagcaag tctcagctga gctacctggt gcacgagcca     2520

cctctggcag tggtggacca caagtccacc tatgaggagg atcgcaagga caaggacatc     2580

ccagtgcagg aggaggtgga gcctgcacca gtgaggcgca tcctgaagtt ttccgcccca     2640

gagtggccct acatgctggt gggatctgtg ggagcagcag tgaacggcac cgtgacacca     2700

ctgtatgcct tcctgttttc ccagatcctg ggcaccttct ctatccccga caaggaggag     2760

cagcggtccc agatcaatgg cgtgtgcctg ctgtttgtgg ctatgggctg cgtgagcctg     2820

tttacacagt tcctgcaggg ctacgccttc gccaagagcg gcgagctgct gaccaagcgg     2880

ctgagaaagt tcggctttag agccatgctg ggccaggaca tcgcctggtt tgacgatctg     2940

cggaacagcc caggcgccct gaccacaaga ctggccacag atgcatctca ggtgcaggga     3000

gcagcaggca gccagatcgg catgatcgtg aactccttca ccaatgtgac agtggccatg     3060

atcatcgcct tcagcttttc ctggaagctg agcctggtca tcctgtgctt cttccccttt     3120

ctggccctga gcggagcaac ccagacaagg atgctgaccg gcttcgcctc cagagacaag     3180

caggccctgg agatggtggg ccagatcaca aacgaggccc tgagcaatat caggaccgtg     3240

gcaggaatcg gcaaggagcg gcggttcatc gaggccctgg agacagagct ggagaagcct     3300

ttcaagaccg ccatccagaa ggccaacatc tacggcttct gctttgcctt cgcccagtgt     3360

atcatgttca tcgccaactc tgccagctac cgctatggcg gctacctgat cagcaatgag     3420

ggcctgcact tcagctacgt gttcagagtg atcagcgccg tggtgctgtc tgccacagcc     3480

ctgggaaggg ccttctccta caccccatct tatgccaagg ccaagatcag cgccgccagg     3540

ttctttcagc tgctggaccg ccagccaccc atcagcgtgt acaacacagc cggcgagaag     3600

tgggataatt tccagggcaa gatcgacttt gtggattgca agttcaccta tcctagcaga     3660

ccagactccc aggtgctgaa tggcctgtcc gtgtctatca gcccaggcca gacactggcc     3720

tttgtgggct cctctggctg tggcaagtcc acctctatcc agctgctgga gcggttctat     3780

gaccccgatc agggcaaagt gatgatcgac ggccacgata gcaagaaggt gaacgtgcag     3840

tttctgagat ccaatatcgg catcgtgtct caggagcctg tgctgttcgc ctgctccatc     3900

atggataaca tcaagtacgg cgacaataca aaggagatcc caatggagag agtgatcgca     3960

gcagcaaagc aggcacagct gcacgatttc gtgatgtccc tgcccgagaa gtatgagaca     4020

aacgtgggct ctcagggcag ccagctgtcc aggggcgaga agcagaggat cgcaatcgcc     4080

agggccatcg tgcgcgatcc caagatcctg ctgctggacg aggccaccag cgccctggat     4140

acagagtccg agaagaccgt gcaggtggcc ctggacaagg cccgggaggg aagaacatgt     4200

atcgtgatcg cccacagact gagcaccatc cagaatgccg acatcatcgc cgtgatggcc     4260

cagggcgtgg tcatcgagaa gggcacccac gaggaactga tggcacagaa aggggcttac     4320

tacaaactgg tcacaacagg ctcacctatc tcatagggat ccatatgata tcaataaaga     4380

cctcttattt tcattcatca ggtgtggttg gtttttttgt gtgggggctc gagatctgag     4440

gaacccctag tgatggaggc ggccgcagga acccctagtg atggagttgg ccactccctc     4500

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     4560

tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc ctgcag                    4606


<210>  14
<211>  4487
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAV-imPr-MDR3co

<400>  14
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcga attccatggt accggttcct gctttgagta tgttcgacct      180

ttcctctcat gtcactgaac tgtgctagat ctggacttta ggccattgac ctataagcaa      240

atagatagtg ttcttaaaaa agcctgattt ctgttcaatg ctttattacc atgaaaactg      300

aacttggaaa ggggtgtaca accctgactt tccacagtgg cgtctctcgc ttctcctggc      360

tccctcaaat tcacagagct cgtcgacgga tccgccgcca ccatggatct ggaggccgcc      420

aagaacggca ccgcctggag acccacaagc gccgagggcg acttcgagct gggcatcagc      480

tccaagcaga agagaaagaa gaccaagaca gtgaagatga tcggcgtgct gacactgttc      540

aggtactccg actggcagga taagctgttt atgtctctgg gcaccatcat ggcaatcgcc      600

cacggcagcg gcctgcctct gatgatgatc gtgttcggcg agatgaccga caagtttgtg      660

gatacagccg gcaatttctc ctttcccgtg aacttctctc tgagcctgct gaaccctggc      720

aagatcctgg aggaggagat gacaagatat gcctactatt actctggcct gggagcaggc      780

gtgctggtgg cagcatacat ccaggtgagc ttctggaccc tggcagcagg ccggcagatc      840

agaaagatca ggcagaagtt ctttcacgcc atcctgcgcc aggagatcgg ctggtttgac      900

atcaatgata ccacagagct gaacacccgg ctgacagacg acatctctaa gatcagcgag      960

ggcatcggcg ataaagtggg catgttcttt caggccgtgg ccacattctt tgccggcttc     1020

atcgtgggct ttatcagggg ctggaagctg accctggtca tcatggccat ctctccaatc     1080

ctgggcctga gcgccgccgt gtgggcaaag atcctgtccg ccttctctga caaggagctg     1140

gccgcctacg ccaaggcagg agcagtggca gaggaggccc tgggcgccat ccgcaccgtg     1200

atcgcctttg gcggccagaa taaggagctg gagcggtatc agaagcacct ggagaacgcc     1260

aaggagatcg gcatcaagaa ggccatctcc gccaatatct ctatgggcat cgccttcctg     1320

ctgatctatg ccagctacgc cctggccttt tggtatggca gcaccctggt catcagcaag     1380

gagtacacca tcggcaatgc catgacagtg ttctttagca tcctgatcgg agccttctcc     1440

gtgggacagg cagcaccatg catcgacgcc ttcgccaacg ccagaggcgc agcctacgtg     1500

atctttgaca tcatcgataa caatccaaag atcgactcct tttctgagcg gggccacaag     1560

cccgattcca tcaagggcaa tctggagttc aacgacgtgc actttagcta tccctcccgc     1620

gccaatgtga agatcctgaa gggcctgaac ctgaaggtgc agtccggaca gacagtggcc     1680

ctggtgggct ctagcggatg cggcaagtct accacagtgc agctgatcca gcggctgtat     1740

gacccagatg agggcaccat caacatcgac ggccaggaca tccgcaactt caatgtgaac     1800

tacctgcggg agatcatcgg cgtggtgtct caggagcccg tgctgtttag caccacaatc     1860

gccgagaata tctgttatgg ccgcggcaac gtgacaatgg atgagatcaa gaaggccgtg     1920

aaggaggcca atgcctacga gttcatcatg aagctgcccc agaagtttga caccctggtg     1980

ggagagagag gcgcccagct gagcggaggc cagaagcaga ggatcgccat cgccagagcc     2040

ctggtgagga accctaagat cctgctgctg gacgaggcca cctccgccct ggatacagag     2100

tctgaggcag aggtgcaggc cgccctggat aaggcccgcg agggacggac cacaatcgtg     2160

atcgcccaca gactgagcac agtgaggaat gccgacgtga tcgccggctt cgaggatggc     2220

gtgatcgtgg agcagggcag ccactccgag ctgatgaaga aggagggcgt gtacttcaag     2280

ctggtgaaca tgcagacctc tggcagccag atccagtccg aggagtttga gctgaatgac     2340

gagaaggcag caacaaggat ggcacctaac ggatggaaga gcagactgtt caggcactcc     2400

acccagaaga atctgaagaa ctctcagatg tgccagaaga gcctggacgt ggaaaccgat     2460

ggactggagg caaatgtgcc acccgtgagc ttcctgaagg tgctgaagct gaacaagaca     2520

gagtggccat attttgtggt gggcaccgtg tgcgcaatcg caaatggcgg cctgcagcca     2580

gccttcagcg tgatcttttc cgagatcatc gccatcttcg gccctggcga cgatgccgtg     2640

aagcagcaga agtgtaacat cttttccctg atcttcctgt ttctgggcat catctctttc     2700

tttaccttct ttctgcaggg cttcacattt ggcaaggccg gcgagatcct gacacggaga     2760

ctgagaagca tggccttcaa ggccatgctg aggcaggata tgtcctggtt tgacgatcac     2820

aagaacagca ccggcgccct gtccaccaga ctggcaacag acgcagcaca ggtgcaggga     2880

gcaaccggca caaggctggc cctgatcgcc cagaatatcg ccaacctggg cacaggcatc     2940

atcatctctt tcatctacgg ctggcagctg accctgctgc tgctggcagt ggtgccaatc     3000

atcgccgtga gcggcatcgt ggagatgaag ctgctggccg gcaatgccaa gagagacaag     3060

aaggagctgg aggcagcagg caagatcgca accgaggcca tcgagaacat ccgcaccgtg     3120

gtgagcctga cacaggagcg gaagttcgag tccatgtatg tggagaagct gtatggccct     3180

taccgcaatt ccgtgcagaa ggcccacatc tacggcatca ccttttccat ctctcaggct     3240

ttcatgtatt tttcttacgc cggctgcttc cggtttggcg cctatctgat cgtgaacggc     3300

cacatgaggt tccgcgatgt gatcctggtg ttctctgcca tcgtgtttgg agcagtggcc     3360

ctgggacacg cctcctcttt tgcccctgac tatgcaaagg caaagctgtc cgccgcacac     3420

ctgttcatgc tgtttgagag acagcctctg atcgatagct actccgagga gggcctgaag     3480

ccagacaagt tcgagggcaa tatcacattc aacgaggtgg tgtttaatta tccaaccagg     3540

gccaacgtgc ccgtgctgca gggcctgagc ctggaggtga agaagggaca gacactggcc     3600

ctggtgggca gctccggatg cggcaagtcc accgtggtgc agctgctgga gagattctac     3660

gaccctctgg caggcaccgt gctgctggat ggacaggagg ccaagaagct gaatgtgcag     3720

tggctgagag cccagctggg catcgtgtct caggagccaa tcctgttcga ttgtagcatc     3780

gccgagaata tcgcctacgg cgacaactct agggtggtga gccaggatga gatcgtgagc     3840

gccgcaaagg cagcaaacat ccaccctttt atcgagaccc tgccacacaa gtatgagaca     3900

cgcgtgggcg acaagggcac ccagctgtcc ggaggacaga agcagaggat cgcaatcgcc     3960

cgcgccctga tcaggcagcc ccagatcctg ctgctggatg aagccacctc cgccctggac     4020

acagagtctg agaaggtggt gcaggaggcc ctggacaaag cccgcgaggg acggacatgt     4080

attgtcattg ctcacagact gagcaccatc cagaatgccg acctgatcgt ggtgttccag     4140

aacggcaggg tgaaggagca cggcacacac cagcagctgc tggcccagaa gggcatctac     4200

ttttctatgg tgagcgtgca ggccggcacc cagaacctgt agcatatgat atcaataaag     4260

acctcttatt ttcattcatc aggtgtggtt ggtttttttg tgtgggggct cgagatctga     4320

ggaaccccta gtgatggagg cggccgcagg aacccctagt gatggagttg gccactccct     4380

ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct     4440

ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg cctgcag                   4487


<210>  15
<211>  14
<212>  DNA
<213>  Artificial sequence

<220>
<223>  human IR-1 element

<400>  15
gggacattga tcct                                                         14


<210>  16
<211>  2662
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-ihPr-LucPEST

<400>  16
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtacc ttcccaagca cactctgtgt ttggggttat      180

tgctctgagt atgtttctcg tatgtcactg aactgtgctt gggctgccct tagggacatt      240

gatccttagg caaatagata atgttcttga aaaagtttga attctgttca gtgctttaga      300

atgatgaaaa ccgaggttgg aaaaggttgt gaaacctttt aactctccac agtggagtcc      360

attatttcct ctggcttcct cgagctcgtc gacgctagct tggcattccg gtactgttgg      420

taaagccacc atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct      480

ggaagatgga accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc      540

tggaacaatt gcttttacag atgcacatat cgaggtggac atcacttacg ctgagtactt      600

cgaaatgtcc gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag      660

aatcgtcgta tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt      720

tatcggagtt gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag      780

tatgggcatt tcgcagccta ccgtggtgtt cgtttccaaa aaggggttgc aaaaaatttt      840

gaacgtgcaa aaaaagctcc caatcatcca aaaaattatt atcatggatt ctaaaacgga      900

ttaccaggga tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa      960

tgaatacgat tttgtgccag agtccttcga tagggacaag acaattgcac tgatcatgaa     1020

ctcctctgga tctactggtc tgcctaaagg tgtcgctctg cctcatagaa ctgcctgcgt     1080

gagattctcg catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat     1140

tttaagtgtt gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat     1200

atgtggattt cgagtcgtct taatgtatag atttgaagaa gagctgtttc tgaggagcct     1260

tcaggattac aagattcaaa gtgcgctgct ggtgccaacc ctattctcct tcttcgccaa     1320

aagcactctg attgacaaat acgatttatc taatttacac gaaattgctt ctggtggcgc     1380

tcccctctct aaggaagtcg gggaagcggt tgccaagagg ttccatctgc caggtatcag     1440

gcaaggatat gggctcactg agactacatc agctattctg attacacccg agggggatga     1500

taaaccgggc gcggtcggta aagttgttcc attttttgaa gcgaaggttg tggatctgga     1560

taccgggaaa acgctgggcg ttaatcaaag aggcgaactg tgtgtgagag gtcctatgat     1620

tatgtccggt tatgtaaaca atccggaagc gaccaacgcc ttgattgaca aggatggatg     1680

gctacattct ggagacatag cttactggga cgaagacgaa cacttcttca tcgttgaccg     1740

cctgaagtct ctgattaagt acaaaggcta tcaggtggct cccgctgaat tggaatccat     1800

cttgctccaa caccccaaca tcttcgacgc aggtgtcgca ggtcttcccg acgatgacgc     1860

cggtgaactt cccgccgccg ttgttgtttt ggagcacgga aagacgatga cggaaaaaga     1920

gatcgtggat tacgtcgcca gtcaagtaac aaccgcgaaa aagttgcgcg gaggagttgt     1980

gtttgtggac gaagtaccga aaggtcttac cggaaaactc gacgcaagaa aaatcagaga     2040

gatcctcata aaggccaaga agggcggaaa gatcgccgtg tcaagccatg gcttcccgcc     2100

ggcggtggcg gcgcaggatg atggcacgct gcccatgtct tgtgcccagg agagcgggat     2160

ggaccgtcac cctgcagcct gtgcttctgc taggatcaat gtgtaggcgg ccaacaatgc     2220

gatccgatgg ccgcgactct agagtcgggg cggccggccg cttcgagcag acatgataag     2280

atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg     2340

tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa     2400

caacaacaat tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta     2460

aagcaagtaa aacctctaca aatgtggtaa aatcgataag cccgtgcgga ccgagcggcc     2520

gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     2580

ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga     2640

gcgagcgcgc agctgcctgc ag                                              2662


<210>  17
<211>  2653
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-imPr-LucPEST

<400>  17
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtacc ggttcctgct ttgagtatgt tcgacctttc      180

ctctcatgtc actgaactgt gctagatctg gactttaggc cattgaccta taagcaaata      240

gatagtgttc ttaaaaaagc ctgatttctg ttcaatgctt tattaccatg aaaactgaac      300

ttggaaaggg gtgtacaacc ctgactttcc acagtggcgt ctctcgcttc tcctggctcc      360

ctcaaattca cagagctcgt cgacgctagc ttggcattcc ggtactgttg gtaaagccac      420

catggaagac gccaaaaaca taaagaaagg cccggcgcca ttctatccgc tggaagatgg      480

aaccgctgga gagcaactgc ataaggctat gaagagatac gccctggttc ctggaacaat      540

tgcttttaca gatgcacata tcgaggtgga catcacttac gctgagtact tcgaaatgtc      600

cgttcggttg gcagaagcta tgaaacgata tgggctgaat acaaatcaca gaatcgtcgt      660

atgcagtgaa aactctcttc aattctttat gccggtgttg ggcgcgttat ttatcggagt      720

tgcagttgcg cccgcgaacg acatttataa tgaacgtgaa ttgctcaaca gtatgggcat      780

ttcgcagcct accgtggtgt tcgtttccaa aaaggggttg caaaaaattt tgaacgtgca      840

aaaaaagctc ccaatcatcc aaaaaattat tatcatggat tctaaaacgg attaccaggg      900

atttcagtcg atgtacacgt tcgtcacatc tcatctacct cccggtttta atgaatacga      960

ttttgtgcca gagtccttcg atagggacaa gacaattgca ctgatcatga actcctctgg     1020

atctactggt ctgcctaaag gtgtcgctct gcctcataga actgcctgcg tgagattctc     1080

gcatgccaga gatcctattt ttggcaatca aatcattccg gatactgcga ttttaagtgt     1140

tgttccattc catcacggtt ttggaatgtt tactacactc ggatatttga tatgtggatt     1200

tcgagtcgtc ttaatgtata gatttgaaga agagctgttt ctgaggagcc ttcaggatta     1260

caagattcaa agtgcgctgc tggtgccaac cctattctcc ttcttcgcca aaagcactct     1320

gattgacaaa tacgatttat ctaatttaca cgaaattgct tctggtggcg ctcccctctc     1380

taaggaagtc ggggaagcgg ttgccaagag gttccatctg ccaggtatca ggcaaggata     1440

tgggctcact gagactacat cagctattct gattacaccc gagggggatg ataaaccggg     1500

cgcggtcggt aaagttgttc cattttttga agcgaaggtt gtggatctgg ataccgggaa     1560

aacgctgggc gttaatcaaa gaggcgaact gtgtgtgaga ggtcctatga ttatgtccgg     1620

ttatgtaaac aatccggaag cgaccaacgc cttgattgac aaggatggat ggctacattc     1680

tggagacata gcttactggg acgaagacga acacttcttc atcgttgacc gcctgaagtc     1740

tctgattaag tacaaaggct atcaggtggc tcccgctgaa ttggaatcca tcttgctcca     1800

acaccccaac atcttcgacg caggtgtcgc aggtcttccc gacgatgacg ccggtgaact     1860

tcccgccgcc gttgttgttt tggagcacgg aaagacgatg acggaaaaag agatcgtgga     1920

ttacgtcgcc agtcaagtaa caaccgcgaa aaagttgcgc ggaggagttg tgtttgtgga     1980

cgaagtaccg aaaggtctta ccggaaaact cgacgcaaga aaaatcagag agatcctcat     2040

aaaggccaag aagggcggaa agatcgccgt gtcaagccat ggcttcccgc cggcggtggc     2100

ggcgcaggat gatggcacgc tgcccatgtc ttgtgcccag gagagcggga tggaccgtca     2160

ccctgcagcc tgtgcttctg ctaggatcaa tgtgtaggcg gccaacaatg cgatccgatg     2220

gccgcgactc tagagtcggg gcggccggcc gcttcgagca gacatgataa gatacattga     2280

tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg     2340

tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa     2400

ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta     2460

aaacctctac aaatgtggta aaatcgataa gcccgtgcgg accgagcggc cgcaggaacc     2520

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg     2580

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg     2640

cagctgcctg cag                                                        2653


<210>  18
<211>  4901
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-mBSEPpr-LucPEST

<400>  18
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtcatagg tagatcttac ctcttagttt ccctttcaga      180

aaggagtggt tatacgatag agtctctgaa tgaaaagtga ataatagtga tgaatgccac      240

tcccaggctt ggtccatgga aactgttcat gtaaaatacc ccatgtgata gttagatgcc      300

aatatctaag gagaccttga aagccgaatc ttcaggataa cagaggcttg tcattctaag      360

tccctggatg actatggaga accttcctcc actacagact tcttctcatg cagagcacag      420

tggacttcac gtgagggtga tgaagttagc aagtgtctta gttagggttt ctattcctgc      480

acaaaacatc atgaccacga agcaagttgg ggaggaaagg gtttattcag cttacatttc      540

cacattgctg ttcatcacca aaagaagtca ggactggaac tcacacaggt caggaagcag      600

aagcggatgc agaggccatg gagggatgtt ccttactggt ttgcttcccc tggcttgctc      660

agcttgcttt cttctagaat ccaagactac cagcccaggg aaggcaccac ccacaatggg      720

ccctcccccc ttgatcacta attgagaaaa tgccttgcag ctggatctta tggaggtctt      780

tcctcaaggg aggttccttt ctctgtataa ctccagcttg tgtcaagttg acacacaaaa      840

ccagccagta gagcaagcat cattaccata gctaaatcga gaagcaagtg ctagaaccta      900

attatgaagc cagttccttt tgcttctctc tgtaatgagt taaacctccc tactctacca      960

aagtacagcc aattatgttg tgttagataa ttggtgttga gtttttccaa ttcattttga     1020

tctgcagggc tataataacc aaacaagagt tgatagttgg tggaagactt ctccacaaaa     1080

ccattcctat tattctgagc cacagggcta acattccagt ctgtctgcaa ttcatctcct     1140

tgattctgaa aactgttctt ggcctacctt caccttctta ggtaagcatg cataccactg     1200

tattgtaccc tttatgctca gtagccatct ctggtgtggt gggtatgctt taagaaccac     1260

agtcttgcaa gctcagcctt ttttcttgtc ctctctctgg cctggaagaa atgaagatag     1320

tgtaaagaga tgctatgtgt ctctccatct gaccatcaga ctactgtagt gaatctggtc     1380

ctcccacctc caaattgaaa tttcctcagg aatctcactc tgggagaaga aagagatacc     1440

agccagagca agaactagtc tcttgagact tcacacaagt ctcacaactt ggtagaccac     1500

ttcaggaacc agcctgaagc ccagtcagtg gtgggcagga tcatatttta actggcactg     1560

ctaagatgtg catttggtgt tctaattaaa ttctggtctc atttcaggag cccaaaactg     1620

gatatacact ggatctctgt atttttttcc caatgggaac actgaataaa tctcctttct     1680

ctgctttcta ttactaactt ggctatttta ttggcctata gaaggcagct gatcggttct     1740

gacttggagc acaagttggg accccatgtc cagtaacaat cttacatccc ctttccagga     1800

agaaatataa aaactaaata gcattttgaa tcatatggcc atattacttt ttataataca     1860

atgcaattga aattaatgaa gaagaaaaat ggtaaaactt gtttttttaa agaaatatgt     1920

ggagattaat agtaagaagg catacgaaaa gtcacagcca gttctaagct tatttgcttt     1980

gaggttttgt taatgggaat gtgtttttta aagtaatgca tttctactta tacagcgctg     2040

cagctagtgg gcagagcttg aggctattga ctgctcagac cagagttcaa gggtcatctg     2100

tgtgcacaga gttctgagca gaaggcaatt gcatgttatc aattctccat gaaactttgg     2160

ggcggctcca gatcactgag ggcctgcaac ccaggatgtc acaagggtca cttccaaata     2220

gagcagagac gataagaagt agtttggtcc tgttagattt ttttaaagtt actttttaaa     2280

acctagggct taaaaaagaa gagtcgggcc tctcaccagg ctctctacca tgaggcccca     2340

ctctcgggca actgggcatt ttctaaagct tgttgatacc ctcagaaggt ccccacgcac     2400

tctgggtttg ggttcctgct ttgagtatgt tcgacctttc ctctcatgtc actgaactgt     2460

gctagatctg gactttaggc cattgaccta taagcaaata gatagtgttc ttaaaaaagc     2520

ctgatttctg ttcaatgctt tattaccatg aaaactgaac ttggaaaggg gtgtacaacc     2580

ctgactttcc acagtggcgt ctctcgcttc tcctggctcc ctcaaattca cagctagctt     2640

ggcattccgg tactgttggt aaagccacca tggaagacgc caaaaacata aagaaaggcc     2700

cggcgccatt ctatccgctg gaagatggaa ccgctggaga gcaactgcat aaggctatga     2760

agagatacgc cctggttcct ggaacaattg cttttacaga tgcacatatc gaggtggaca     2820

tcacttacgc tgagtacttc gaaatgtccg ttcggttggc agaagctatg aaacgatatg     2880

ggctgaatac aaatcacaga atcgtcgtat gcagtgaaaa ctctcttcaa ttctttatgc     2940

cggtgttggg cgcgttattt atcggagttg cagttgcgcc cgcgaacgac atttataatg     3000

aacgtgaatt gctcaacagt atgggcattt cgcagcctac cgtggtgttc gtttccaaaa     3060

aggggttgca aaaaattttg aacgtgcaaa aaaagctccc aatcatccaa aaaattatta     3120

tcatggattc taaaacggat taccagggat ttcagtcgat gtacacgttc gtcacatctc     3180

atctacctcc cggttttaat gaatacgatt ttgtgccaga gtccttcgat agggacaaga     3240

caattgcact gatcatgaac tcctctggat ctactggtct gcctaaaggt gtcgctctgc     3300

ctcatagaac tgcctgcgtg agattctcgc atgccagaga tcctattttt ggcaatcaaa     3360

tcattccgga tactgcgatt ttaagtgttg ttccattcca tcacggtttt ggaatgttta     3420

ctacactcgg atatttgata tgtggatttc gagtcgtctt aatgtataga tttgaagaag     3480

agctgtttct gaggagcctt caggattaca agattcaaag tgcgctgctg gtgccaaccc     3540

tattctcctt cttcgccaaa agcactctga ttgacaaata cgatttatct aatttacacg     3600

aaattgcttc tggtggcgct cccctctcta aggaagtcgg ggaagcggtt gccaagaggt     3660

tccatctgcc aggtatcagg caaggatatg ggctcactga gactacatca gctattctga     3720

ttacacccga gggggatgat aaaccgggcg cggtcggtaa agttgttcca ttttttgaag     3780

cgaaggttgt ggatctggat accgggaaaa cgctgggcgt taatcaaaga ggcgaactgt     3840

gtgtgagagg tcctatgatt atgtccggtt atgtaaacaa tccggaagcg accaacgcct     3900

tgattgacaa ggatggatgg ctacattctg gagacatagc ttactgggac gaagacgaac     3960

acttcttcat cgttgaccgc ctgaagtctc tgattaagta caaaggctat caggtggctc     4020

ccgctgaatt ggaatccatc ttgctccaac accccaacat cttcgacgca ggtgtcgcag     4080

gtcttcccga cgatgacgcc ggtgaacttc ccgccgccgt tgttgttttg gagcacggaa     4140

agacgatgac ggaaaaagag atcgtggatt acgtcgccag tcaagtaaca accgcgaaaa     4200

agttgcgcgg aggagttgtg tttgtggacg aagtaccgaa aggtcttacc ggaaaactcg     4260

acgcaagaaa aatcagagag atcctcataa aggccaagaa gggcggaaag atcgccgtgt     4320

caagccatgg cttcccgccg gcggtggcgg cgcaggatga tggcacgctg cccatgtctt     4380

gtgcccagga gagcgggatg gaccgtcacc ctgcagcctg tgcttctgct aggatcaatg     4440

tgtaggcggc caacaatgcg atccgatggc cgcgactcta gagtcggggc ggccggccgc     4500

ttcgagcaga catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt     4560

gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa     4620

gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg     4680

aggtgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtaaa atcgataagc     4740

ccgtgcggac cgagcggccg caggaacccc tagtgatgga gttggccact ccctctctgc     4800

gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc     4860

gggcggcctc agtgagcgag cgagcgcgca gctgcctgca g                         4901


<210>  19
<211>  302
<212>  DNA
<213>  Artificial sequence

<220>
<223>  imPR+5xIR

<400>  19
ttaggccatt gacctattag gccattgacc tattaggcca ttgacctatt aggccattga       60

cctattaggc cattgaccta ggttcctgct ttgagtatgt tcgacctttc ctctcatgtc      120

actgaactgt gctagatctg gactttaggc cattgaccta taagcaaata gatagtgttc      180

ttaaaaaagc ctgatttctg ttcaatgctt tattaccatg aaaactgaac ttggaaaggg      240

gtgtacaacc ctgactttcc acagtggcgt ctctcgcttc tcctggctcc ctcaaattca      300

ca                                                                     302


<210>  20
<211>  288
<212>  DNA
<213>  Artificial sequence

<220>
<223>  imPr+3xIR-ER2

<400>  20
tggactttag gccattgacc tatggacttt aggccattga cctatggact ttaggccatt       60

gacctaggtt cctgctttga gtatgttcga cctttcctct catgtcactg aactgtgcta      120

gatctggact ttaggccatt gacctataag caaatagata gtgttcttaa aaaagcctga      180

tttctgttca atgctttatt accatgaaaa ctgaacttgg aaaggggtgt acaaccctga      240

ctttccacag tggcgtctct cgcttctcct ggctccctca aattcaca                   288


<210>  21
<211>  273
<212>  DNA
<213>  Artificial sequence

<220>
<223>  imPr+ LRH-1

<400>  21
tttctaaagc ttgttgatac cctcagaagg tccccacgca ctctgggttt gggttcctgc       60

tttgagtatg ttcgaccttt cctctcatgt cactgaactg tgctagatct ggactttagg      120

ccattgacct ataagcaaat agatagtgtt cttaaaaaag cctgatttct gttcaatgct      180

ttattaccat gaaaactgaa cttggaaagg ggtgtacaac cctgactttc cacagtggcg      240

tctctcgctt ctcctggctc cctcaaattc aca                                   273


<210>  22
<211>  2669
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-imPr+1xIR-LucPEST

<400>  22
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtacc ttaggccatt gacctaggtt cctgctttga      180

gtatgttcga cctttcctct catgtcactg aactgtgcta gatctggact ttaggccatt      240

gacctataag caaatagata gtgttcttaa aaaagcctga tttctgttca atgctttatt      300

accatgaaaa ctgaacttgg aaaggggtgt acaaccctga ctttccacag tggcgtctct      360

cgcttctcct ggctccctca aattcacaga gctcgtcgac gctagcttgg cattccggta      420

ctgttggtaa agccaccatg gaagacgcca aaaacataaa gaaaggcccg gcgccattct      480

atccgctgga agatggaacc gctggagagc aactgcataa ggctatgaag agatacgccc      540

tggttcctgg aacaattgct tttacagatg cacatatcga ggtggacatc acttacgctg      600

agtacttcga aatgtccgtt cggttggcag aagctatgaa acgatatggg ctgaatacaa      660

atcacagaat cgtcgtatgc agtgaaaact ctcttcaatt ctttatgccg gtgttgggcg      720

cgttatttat cggagttgca gttgcgcccg cgaacgacat ttataatgaa cgtgaattgc      780

tcaacagtat gggcatttcg cagcctaccg tggtgttcgt ttccaaaaag gggttgcaaa      840

aaattttgaa cgtgcaaaaa aagctcccaa tcatccaaaa aattattatc atggattcta      900

aaacggatta ccagggattt cagtcgatgt acacgttcgt cacatctcat ctacctcccg      960

gttttaatga atacgatttt gtgccagagt ccttcgatag ggacaagaca attgcactga     1020

tcatgaactc ctctggatct actggtctgc ctaaaggtgt cgctctgcct catagaactg     1080

cctgcgtgag attctcgcat gccagagatc ctatttttgg caatcaaatc attccggata     1140

ctgcgatttt aagtgttgtt ccattccatc acggttttgg aatgtttact acactcggat     1200

atttgatatg tggatttcga gtcgtcttaa tgtatagatt tgaagaagag ctgtttctga     1260

ggagccttca ggattacaag attcaaagtg cgctgctggt gccaacccta ttctccttct     1320

tcgccaaaag cactctgatt gacaaatacg atttatctaa tttacacgaa attgcttctg     1380

gtggcgctcc cctctctaag gaagtcgggg aagcggttgc caagaggttc catctgccag     1440

gtatcaggca aggatatggg ctcactgaga ctacatcagc tattctgatt acacccgagg     1500

gggatgataa accgggcgcg gtcggtaaag ttgttccatt ttttgaagcg aaggttgtgg     1560

atctggatac cgggaaaacg ctgggcgtta atcaaagagg cgaactgtgt gtgagaggtc     1620

ctatgattat gtccggttat gtaaacaatc cggaagcgac caacgccttg attgacaagg     1680

atggatggct acattctgga gacatagctt actgggacga agacgaacac ttcttcatcg     1740

ttgaccgcct gaagtctctg attaagtaca aaggctatca ggtggctccc gctgaattgg     1800

aatccatctt gctccaacac cccaacatct tcgacgcagg tgtcgcaggt cttcccgacg     1860

atgacgccgg tgaacttccc gccgccgttg ttgttttgga gcacggaaag acgatgacgg     1920

aaaaagagat cgtggattac gtcgccagtc aagtaacaac cgcgaaaaag ttgcgcggag     1980

gagttgtgtt tgtggacgaa gtaccgaaag gtcttaccgg aaaactcgac gcaagaaaaa     2040

tcagagagat cctcataaag gccaagaagg gcggaaagat cgccgtgtca agccatggct     2100

tcccgccggc ggtggcggcg caggatgatg gcacgctgcc catgtcttgt gcccaggaga     2160

gcgggatgga ccgtcaccct gcagcctgtg cttctgctag gatcaatgtg taggcggcca     2220

acaatgcgat ccgatggccg cgactctaga gtcggggcgg ccggccgctt cgagcagaca     2280

tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct     2340

ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac     2400

aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag gtgtgggagg     2460

ttttttaaag caagtaaaac ctctacaaat gtggtaaaat cgataagccc gtgcggaccg     2520

agcggccgca ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     2580

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     2640

tgagcgagcg agcgcgcagc tgcctgcag                                       2669


<210>  23
<211>  2701
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-imPr+3xIR-LucPEST

<400>  23
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtacc ttaggccatt gacctattag gccattgacc      180

tattaggcca ttgacctagg ttcctgcttt gagtatgttc gacctttcct ctcatgtcac      240

tgaactgtgc tagatctgga ctttaggcca ttgacctata agcaaataga tagtgttctt      300

aaaaaagcct gatttctgtt caatgcttta ttaccatgaa aactgaactt ggaaaggggt      360

gtacaaccct gactttccac agtggcgtct ctcgcttctc ctggctccct caaattcaca      420

gagctcgtcg acgctagctt ggcattccgg tactgttggt aaagccacca tggaagacgc      480

caaaaacata aagaaaggcc cggcgccatt ctatccgctg gaagatggaa ccgctggaga      540

gcaactgcat aaggctatga agagatacgc cctggttcct ggaacaattg cttttacaga      600

tgcacatatc gaggtggaca tcacttacgc tgagtacttc gaaatgtccg ttcggttggc      660

agaagctatg aaacgatatg ggctgaatac aaatcacaga atcgtcgtat gcagtgaaaa      720

ctctcttcaa ttctttatgc cggtgttggg cgcgttattt atcggagttg cagttgcgcc      780

cgcgaacgac atttataatg aacgtgaatt gctcaacagt atgggcattt cgcagcctac      840

cgtggtgttc gtttccaaaa aggggttgca aaaaattttg aacgtgcaaa aaaagctccc      900

aatcatccaa aaaattatta tcatggattc taaaacggat taccagggat ttcagtcgat      960

gtacacgttc gtcacatctc atctacctcc cggttttaat gaatacgatt ttgtgccaga     1020

gtccttcgat agggacaaga caattgcact gatcatgaac tcctctggat ctactggtct     1080

gcctaaaggt gtcgctctgc ctcatagaac tgcctgcgtg agattctcgc atgccagaga     1140

tcctattttt ggcaatcaaa tcattccgga tactgcgatt ttaagtgttg ttccattcca     1200

tcacggtttt ggaatgttta ctacactcgg atatttgata tgtggatttc gagtcgtctt     1260

aatgtataga tttgaagaag agctgtttct gaggagcctt caggattaca agattcaaag     1320

tgcgctgctg gtgccaaccc tattctcctt cttcgccaaa agcactctga ttgacaaata     1380

cgatttatct aatttacacg aaattgcttc tggtggcgct cccctctcta aggaagtcgg     1440

ggaagcggtt gccaagaggt tccatctgcc aggtatcagg caaggatatg ggctcactga     1500

gactacatca gctattctga ttacacccga gggggatgat aaaccgggcg cggtcggtaa     1560

agttgttcca ttttttgaag cgaaggttgt ggatctggat accgggaaaa cgctgggcgt     1620

taatcaaaga ggcgaactgt gtgtgagagg tcctatgatt atgtccggtt atgtaaacaa     1680

tccggaagcg accaacgcct tgattgacaa ggatggatgg ctacattctg gagacatagc     1740

ttactgggac gaagacgaac acttcttcat cgttgaccgc ctgaagtctc tgattaagta     1800

caaaggctat caggtggctc ccgctgaatt ggaatccatc ttgctccaac accccaacat     1860

cttcgacgca ggtgtcgcag gtcttcccga cgatgacgcc ggtgaacttc ccgccgccgt     1920

tgttgttttg gagcacggaa agacgatgac ggaaaaagag atcgtggatt acgtcgccag     1980

tcaagtaaca accgcgaaaa agttgcgcgg aggagttgtg tttgtggacg aagtaccgaa     2040

aggtcttacc ggaaaactcg acgcaagaaa aatcagagag atcctcataa aggccaagaa     2100

gggcggaaag atcgccgtgt caagccatgg cttcccgccg gcggtggcgg cgcaggatga     2160

tggcacgctg cccatgtctt gtgcccagga gagcgggatg gaccgtcacc ctgcagcctg     2220

tgcttctgct aggatcaatg tgtaggcggc caacaatgcg atccgatggc cgcgactcta     2280

gagtcggggc ggccggccgc ttcgagcaga catgataaga tacattgatg agtttggaca     2340

aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc     2400

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt     2460

tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa     2520

atgtggtaaa atcgataagc ccgtgcggac cgagcggccg caggaacccc tagtgatgga     2580

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     2640

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca     2700

g                                                                     2701


<210>  24
<211>  2733
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-imPr+3xIR-LucPEST

<400>  24
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtacc ttaggccatt gacctattag gccattgacc      180

tattaggcca ttgacctatt aggccattga cctattaggc cattgaccta ggttcctgct      240

ttgagtatgt tcgacctttc ctctcatgtc actgaactgt gctagatctg gactttaggc      300

cattgaccta taagcaaata gatagtgttc ttaaaaaagc ctgatttctg ttcaatgctt      360

tattaccatg aaaactgaac ttggaaaggg gtgtacaacc ctgactttcc acagtggcgt      420

ctctcgcttc tcctggctcc ctcaaattca cagagctcgt cgacgctagc ttggcattcc      480

ggtactgttg gtaaagccac catggaagac gccaaaaaca taaagaaagg cccggcgcca      540

ttctatccgc tggaagatgg aaccgctgga gagcaactgc ataaggctat gaagagatac      600

gccctggttc ctggaacaat tgcttttaca gatgcacata tcgaggtgga catcacttac      660

gctgagtact tcgaaatgtc cgttcggttg gcagaagcta tgaaacgata tgggctgaat      720

acaaatcaca gaatcgtcgt atgcagtgaa aactctcttc aattctttat gccggtgttg      780

ggcgcgttat ttatcggagt tgcagttgcg cccgcgaacg acatttataa tgaacgtgaa      840

ttgctcaaca gtatgggcat ttcgcagcct accgtggtgt tcgtttccaa aaaggggttg      900

caaaaaattt tgaacgtgca aaaaaagctc ccaatcatcc aaaaaattat tatcatggat      960

tctaaaacgg attaccaggg atttcagtcg atgtacacgt tcgtcacatc tcatctacct     1020

cccggtttta atgaatacga ttttgtgcca gagtccttcg atagggacaa gacaattgca     1080

ctgatcatga actcctctgg atctactggt ctgcctaaag gtgtcgctct gcctcataga     1140

actgcctgcg tgagattctc gcatgccaga gatcctattt ttggcaatca aatcattccg     1200

gatactgcga ttttaagtgt tgttccattc catcacggtt ttggaatgtt tactacactc     1260

ggatatttga tatgtggatt tcgagtcgtc ttaatgtata gatttgaaga agagctgttt     1320

ctgaggagcc ttcaggatta caagattcaa agtgcgctgc tggtgccaac cctattctcc     1380

ttcttcgcca aaagcactct gattgacaaa tacgatttat ctaatttaca cgaaattgct     1440

tctggtggcg ctcccctctc taaggaagtc ggggaagcgg ttgccaagag gttccatctg     1500

ccaggtatca ggcaaggata tgggctcact gagactacat cagctattct gattacaccc     1560

gagggggatg ataaaccggg cgcggtcggt aaagttgttc cattttttga agcgaaggtt     1620

gtggatctgg ataccgggaa aacgctgggc gttaatcaaa gaggcgaact gtgtgtgaga     1680

ggtcctatga ttatgtccgg ttatgtaaac aatccggaag cgaccaacgc cttgattgac     1740

aaggatggat ggctacattc tggagacata gcttactggg acgaagacga acacttcttc     1800

atcgttgacc gcctgaagtc tctgattaag tacaaaggct atcaggtggc tcccgctgaa     1860

ttggaatcca tcttgctcca acaccccaac atcttcgacg caggtgtcgc aggtcttccc     1920

gacgatgacg ccggtgaact tcccgccgcc gttgttgttt tggagcacgg aaagacgatg     1980

acggaaaaag agatcgtgga ttacgtcgcc agtcaagtaa caaccgcgaa aaagttgcgc     2040

ggaggagttg tgtttgtgga cgaagtaccg aaaggtctta ccggaaaact cgacgcaaga     2100

aaaatcagag agatcctcat aaaggccaag aagggcggaa agatcgccgt gtcaagccat     2160

ggcttcccgc cggcggtggc ggcgcaggat gatggcacgc tgcccatgtc ttgtgcccag     2220

gagagcggga tggaccgtca ccctgcagcc tgtgcttctg ctaggatcaa tgtgtaggcg     2280

gccaacaatg cgatccgatg gccgcgactc tagagtcggg gcggccggcc gcttcgagca     2340

gacatgataa gatacattga tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa     2400

tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat     2460

aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg     2520

gaggtttttt aaagcaagta aaacctctac aaatgtggta aaatcgataa gcccgtgcgg     2580

accgagcggc cgcaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     2640

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     2700

tcagtgagcg agcgagcgcg cagctgcctg cag                                  2733


<210>  25
<211>  2719
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-imPr+3xIR-ER2-LucPEST

<400>  25
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtacc tggactttag gccattgacc tatggacttt      180

aggccattga cctatggact ttaggccatt gacctaggtt cctgctttga gtatgttcga      240

cctttcctct catgtcactg aactgtgcta gatctggact ttaggccatt gacctataag      300

caaatagata gtgttcttaa aaaagcctga tttctgttca atgctttatt accatgaaaa      360

ctgaacttgg aaaggggtgt acaaccctga ctttccacag tggcgtctct cgcttctcct      420

ggctccctca aattcacaga gctcgtcgac gctagcttgg cattccggta ctgttggtaa      480

agccaccatg gaagacgcca aaaacataaa gaaaggcccg gcgccattct atccgctgga      540

agatggaacc gctggagagc aactgcataa ggctatgaag agatacgccc tggttcctgg      600

aacaattgct tttacagatg cacatatcga ggtggacatc acttacgctg agtacttcga      660

aatgtccgtt cggttggcag aagctatgaa acgatatggg ctgaatacaa atcacagaat      720

cgtcgtatgc agtgaaaact ctcttcaatt ctttatgccg gtgttgggcg cgttatttat      780

cggagttgca gttgcgcccg cgaacgacat ttataatgaa cgtgaattgc tcaacagtat      840

gggcatttcg cagcctaccg tggtgttcgt ttccaaaaag gggttgcaaa aaattttgaa      900

cgtgcaaaaa aagctcccaa tcatccaaaa aattattatc atggattcta aaacggatta      960

ccagggattt cagtcgatgt acacgttcgt cacatctcat ctacctcccg gttttaatga     1020

atacgatttt gtgccagagt ccttcgatag ggacaagaca attgcactga tcatgaactc     1080

ctctggatct actggtctgc ctaaaggtgt cgctctgcct catagaactg cctgcgtgag     1140

attctcgcat gccagagatc ctatttttgg caatcaaatc attccggata ctgcgatttt     1200

aagtgttgtt ccattccatc acggttttgg aatgtttact acactcggat atttgatatg     1260

tggatttcga gtcgtcttaa tgtatagatt tgaagaagag ctgtttctga ggagccttca     1320

ggattacaag attcaaagtg cgctgctggt gccaacccta ttctccttct tcgccaaaag     1380

cactctgatt gacaaatacg atttatctaa tttacacgaa attgcttctg gtggcgctcc     1440

cctctctaag gaagtcgggg aagcggttgc caagaggttc catctgccag gtatcaggca     1500

aggatatggg ctcactgaga ctacatcagc tattctgatt acacccgagg gggatgataa     1560

accgggcgcg gtcggtaaag ttgttccatt ttttgaagcg aaggttgtgg atctggatac     1620

cgggaaaacg ctgggcgtta atcaaagagg cgaactgtgt gtgagaggtc ctatgattat     1680

gtccggttat gtaaacaatc cggaagcgac caacgccttg attgacaagg atggatggct     1740

acattctgga gacatagctt actgggacga agacgaacac ttcttcatcg ttgaccgcct     1800

gaagtctctg attaagtaca aaggctatca ggtggctccc gctgaattgg aatccatctt     1860

gctccaacac cccaacatct tcgacgcagg tgtcgcaggt cttcccgacg atgacgccgg     1920

tgaacttccc gccgccgttg ttgttttgga gcacggaaag acgatgacgg aaaaagagat     1980

cgtggattac gtcgccagtc aagtaacaac cgcgaaaaag ttgcgcggag gagttgtgtt     2040

tgtggacgaa gtaccgaaag gtcttaccgg aaaactcgac gcaagaaaaa tcagagagat     2100

cctcataaag gccaagaagg gcggaaagat cgccgtgtca agccatggct tcccgccggc     2160

ggtggcggcg caggatgatg gcacgctgcc catgtcttgt gcccaggaga gcgggatgga     2220

ccgtcaccct gcagcctgtg cttctgctag gatcaatgtg taggcggcca acaatgcgat     2280

ccgatggccg cgactctaga gtcggggcgg ccggccgctt cgagcagaca tgataagata     2340

cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga     2400

aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa     2460

caacaattgc attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaaag     2520

caagtaaaac ctctacaaat gtggtaaaat cgataagccc gtgcggaccg agcggccgca     2580

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     2640

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg     2700

agcgcgcagc tgcctgcag                                                  2719


<210>  26
<211>  2704
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-imPr+LRH-1-LucPEST

<400>  26
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtggtacc tttctaaagc ttgttgatac cctcagaagg      180

tccccacgca ctctgggttt gggttcctgc tttgagtatg ttcgaccttt cctctcatgt      240

cactgaactg tgctagatct ggactttagg ccattgacct ataagcaaat agatagtgtt      300

cttaaaaaag cctgatttct gttcaatgct ttattaccat gaaaactgaa cttggaaagg      360

ggtgtacaac cctgactttc cacagtggcg tctctcgctt ctcctggctc cctcaaattc      420

acagagctcg tcgacgctag cttggcattc cggtactgtt ggtaaagcca ccatggaaga      480

cgccaaaaac ataaagaaag gcccggcgcc attctatccg ctggaagatg gaaccgctgg      540

agagcaactg cataaggcta tgaagagata cgccctggtt cctggaacaa ttgcttttac      600

agatgcacat atcgaggtgg acatcactta cgctgagtac ttcgaaatgt ccgttcggtt      660

ggcagaagct atgaaacgat atgggctgaa tacaaatcac agaatcgtcg tatgcagtga      720

aaactctctt caattcttta tgccggtgtt gggcgcgtta tttatcggag ttgcagttgc      780

gcccgcgaac gacatttata atgaacgtga attgctcaac agtatgggca tttcgcagcc      840

taccgtggtg ttcgtttcca aaaaggggtt gcaaaaaatt ttgaacgtgc aaaaaaagct      900

cccaatcatc caaaaaatta ttatcatgga ttctaaaacg gattaccagg gatttcagtc      960

gatgtacacg ttcgtcacat ctcatctacc tcccggtttt aatgaatacg attttgtgcc     1020

agagtccttc gatagggaca agacaattgc actgatcatg aactcctctg gatctactgg     1080

tctgcctaaa ggtgtcgctc tgcctcatag aactgcctgc gtgagattct cgcatgccag     1140

agatcctatt tttggcaatc aaatcattcc ggatactgcg attttaagtg ttgttccatt     1200

ccatcacggt tttggaatgt ttactacact cggatatttg atatgtggat ttcgagtcgt     1260

cttaatgtat agatttgaag aagagctgtt tctgaggagc cttcaggatt acaagattca     1320

aagtgcgctg ctggtgccaa ccctattctc cttcttcgcc aaaagcactc tgattgacaa     1380

atacgattta tctaatttac acgaaattgc ttctggtggc gctcccctct ctaaggaagt     1440

cggggaagcg gttgccaaga ggttccatct gccaggtatc aggcaaggat atgggctcac     1500

tgagactaca tcagctattc tgattacacc cgagggggat gataaaccgg gcgcggtcgg     1560

taaagttgtt ccattttttg aagcgaaggt tgtggatctg gataccggga aaacgctggg     1620

cgttaatcaa agaggcgaac tgtgtgtgag aggtcctatg attatgtccg gttatgtaaa     1680

caatccggaa gcgaccaacg ccttgattga caaggatgga tggctacatt ctggagacat     1740

agcttactgg gacgaagacg aacacttctt catcgttgac cgcctgaagt ctctgattaa     1800

gtacaaaggc tatcaggtgg ctcccgctga attggaatcc atcttgctcc aacaccccaa     1860

catcttcgac gcaggtgtcg caggtcttcc cgacgatgac gccggtgaac ttcccgccgc     1920

cgttgttgtt ttggagcacg gaaagacgat gacggaaaaa gagatcgtgg attacgtcgc     1980

cagtcaagta acaaccgcga aaaagttgcg cggaggagtt gtgtttgtgg acgaagtacc     2040

gaaaggtctt accggaaaac tcgacgcaag aaaaatcaga gagatcctca taaaggccaa     2100

gaagggcgga aagatcgccg tgtcaagcca tggcttcccg ccggcggtgg cggcgcagga     2160

tgatggcacg ctgcccatgt cttgtgccca ggagagcggg atggaccgtc accctgcagc     2220

ctgtgcttct gctaggatca atgtgtaggc ggccaacaat gcgatccgat ggccgcgact     2280

ctagagtcgg ggcggccggc cgcttcgagc agacatgata agatacattg atgagtttgg     2340

acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat     2400

tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca     2460

ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt aaaacctcta     2520

caaatgtggt aaaatcgata agcccgtgcg gaccgagcgg ccgcaggaac ccctagtgat     2580

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     2640

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct     2700

gcag                                                                  2704


