﻿               SEQUENCE LISTING

<110> XL-PROTEIN GMBH
      TECHNISCHE UNIVERSITÄT MÜNCHEN

<120> Antibodies specific for structurally disordered sequences

<130> AD2541 PCT S3

<150> EP 20 216 744.1
<151> 2020-12-22

<160> 94

<170> BiSSAP 1.3.6

<210> 1
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for a 20mer building block of PAS#1

<400> 1
Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      
Ser Ala Pro Ala 
            20  

<210> 2
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for a 20mer building block of P/A#1

<400> 2
Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      
Ala Ala Pro Ala 
            20  

<210> 3
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for a 20mer building block of APSA

<400> 3
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
1               5                   10                  15      
Ala Pro Ser Ala 
            20  

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> BLOCKED

<220> 
<223> Amino acid sequence of the peptide used in fluorescence
      titration, N-terminally modified with ortho-aminobenzoic acid

<400> 4
Ala Pro Ala Pro Ala Ala Pro Ala 
1               5               

<210> 5
<211> 41
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> PYRROLIDONE CARBOXYLIC ACID

<220> 
<223> Amino acid sequence for the PAS#1(40) polymer used for the
      immunogen, N-terminally modified with Pga, C-terminally modified
      with Ahx

<220> 
<221> MOD_RES
<222> 41
<223> BLOCKED

<400> 5
Glu Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
1               5                   10                  15      
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
            20                  25                  30          
Ala Ala Pro Ala Pro Ser Ala Pro Ala 
        35                  40      

<210> 6
<211> 41
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> PYRROLIDONE CARBOXYLIC ACID

<220> 
<223> Amino acid sequence for the P/A#1(40) polymer used for the
      immunogen, N-terminally modified with Pga, C-terminally modified
      with Ahx

<220> 
<221> MOD_RES
<222> 41
<223> BLOCKED

<400> 6
Glu Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
1               5                   10                  15      
Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
            20                  25                  30          
Ala Ala Pro Ala Pro Ala Ala Pro Ala 
        35                  40      

<210> 7
<211> 41
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> PYRROLIDONE CARBOXYLIC ACID

<220> 
<223> Amino acid sequence for the APSA(40) polymer used for the
      immunogen, N-terminally modified with Pga, C-terminally modified
      with Ahx

<220> 
<221> MOD_RES
<222> 41
<223> BLOCKED

<400> 7
Glu Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser 
1               5                   10                  15      
Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser 
            20                  25                  30          
Ala Ala Pro Ser Ala Ala Pro Ser Ala 
        35                  40      

<210> 8
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope PAPAAP

<400> 8
Pro Ala Pro Ala Ala Pro 
1               5       

<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope PAPASP

<400> 9
Pro Ala Pro Ala Ser Pro 
1               5       

<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope PASPAAP

<400> 10
Pro Ala Ser Pro Ala Ala Pro 
1               5           

<210> 11
<211> 120
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.1 heavy chain variable
      region

<400> 11
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          
Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Met Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Tyr Tyr Gly Arg Arg Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 

<210> 12
<211> 112
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.1 light chain variable
      region

<400> 12
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          
Gly Tyr Asn Tyr Met Phe Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Trp Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105                 110         



<210> 13
<211> 123
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.2 heavy chain variable
      region

<400> 13
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val 
        35                  40                  45              
Ala Thr Ile Asn Ser Asn Gly Gly Ser Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Arg Gly Gly Ser Ile Tyr Asp Gly Tyr Asp Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             

<210> 14
<211> 112
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.2 light chain variable
      region

<400> 14
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          
Ser Tyr Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      
Glu Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105                 110         



<210> 15
<211> 121
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.1 heavy chain variable
      region

<400> 15
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          
Asp Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Leu Ala Asn Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Ser Ala 
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  
Phe Leu Lys Ile Ser Ser Val Asp Ala Thr Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Gln Met Arg Asp Asn Tyr Gly Val Trp Phe Ala Phe Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     

<210> 16
<211> 113
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.1 light chain variable
      region

<400> 16
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          
Asn Arg Glu Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Asn Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Asn Tyr Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         
Arg 
    

<210> 17
<211> 121
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.2 heavy chain variable
      region

<400> 17
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Thr Tyr 
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Leu Ala Asn Ile Trp Trp Thr Asp Asp Lys Tyr Tyr Asn Ser Val 
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Phe Asn Asn Gln Val 
65                  70                  75                  80  
Phe Leu Lys Ile Ser Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Gln Leu Ala Tyr His Asp Asn Pro Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     

<210> 18
<211> 113
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.2 light chain variable
      region

<400> 18
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      
Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Asn Tyr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 19
<211> 112
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.1 heavy chain variable
      region

<400> 19
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Leu Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile His Pro Gly Ser Gly Asn Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Asn Leu Trp Gly Arg Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         



<210> 20
<211> 113
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.1 light chain variable
      region

<400> 20
Asp Val Val Met Thr Gln Thr Pro Val Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Gly Gln Ser Leu Leu His Ser 
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Asp Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Leu Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 21
<211> 114
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.2 heavy chain variable
      region

<400> 21
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Leu Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Glu Met Phe Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Cys Ile 
        35                  40                  45              
Gly Thr Ile His Pro Gly Ser Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Asn Asp Arg Gly Ser Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 22
<211> 113
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.2 light chain variable
      region

<400> 22
Asp Val Val Leu Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Asp Gly Lys Thr Phe Leu Asn Trp Leu Leu Gln Arg Pro Gly Leu Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 23
<211> 360
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 1.1 heavy chain variable
      region

<400> 23
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc      60

acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaattgggt tcgccagcct     120

ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaatcac agactataat     180

tcagctctca aatccagact gagcatcagc aaggacaact ccaagagtca agttttctta     240

aaaatgaaca gtctgcaaac tgatgacaca gccaggtact actgtgccag ggattactac     300

ggtaggaggt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca     360


<210> 24
<211> 336
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 1.1 light chain variable
      region

<400> 24
gacattgtac tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc      60

atctcatgca gggccagcaa aagtgtcagt tcatctggct ataattatat gttctggtac     120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct     180

ggggtccctg acaggttctg gggcagtggg tctgggacag acttcaccct caacatccat     240

cctgtggagg aggaggatgc agcaacctat tactgtcagc acagtaggga gcttcctcta     300

acgttcggtg ctgggaccaa gctggagctg aaacgg                               336


<210> 25
<211> 369
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 1.2 heavy chain variable
      region

<400> 25
gaggtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgaaactc      60

tcctgtgcag cctctggatt cactttcagt agctatggca tgtcttgggt tcgccagact     120

ccagacaaga ggctggagtt ggtcgcaacc attaatagta atggtggtag cacctattat     180

ctagacagtg tgaagggccg attcaccatc tccagagaca aagccaagaa caccctgtac     240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgt aagagggggg     300

tcgatctatg atggttacga ctatgctatg gactactggg gtcaaggaac ctcagtcacc     360

gtctcctca                                                             369


<210> 26
<211> 336
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 1.2 light chain variable
      region

<400> 26
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc      60

atctcatgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggttc     120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagagtct     180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat     240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattcctctc     300

acgttcggtg ctgggaccaa gctggagctg aaacgg                               336


<210> 27
<211> 363
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 2.1 heavy chain variable
      region

<400> 27
caggtcactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg      60

acttgttctt tctctgggtt ttcactgagc acttatgata tgggtgtagg ttggattcgt     120

cagccttcag ggaagggtct ggagtggctg gccaacattt ggtggaatga taataaatac     180

tataactcag ccctgaagag ccgcctcaca atctccaagg atacctccaa caaccaggtg     240

ttcctcaaga tctccagtgt ggacgctaca gatactgcca catattattg tgctcaaatg     300

agggataact acggagtttg gtttgctttc tggggccaag ggactctggt cactgtctct     360

gca                                                                   363


<210> 28
<211> 339
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 2.1 light chain variable
      region

<400> 28
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact      60

atgagctgca agtccagtca gagccttttt tatagtaaca gggaaaagaa ctacttggcc     120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg     180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc     240

atcagcaatg tgaaggctga agacctggca gtttattact gtcagcaata ttataactat     300

cccacgttcg gtgctgggac caagctggag ctgaaacgg                            339


<210> 29
<211> 363
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 2.2 heavy chain variable
      region

<400> 29
caggtcactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg      60

acttgttctt tctctgggtt ttcactgaac acttatggta tgggtgtagg ttggattcgt     120

cagccttcag ggaagggtct ggagtggctg gccaacattt ggtggactga tgataagtac     180

tataattcag tcctgaagag ccggctcaca atctccaagg ataccttcaa caaccaggta     240

ttcctcaaga tctccagtgt ggacactgca gatactgcca catactactg tgctcaacta     300

gcctatcatg ataacccctg gtttgcttac tggggccaag ggactctggt cactgtctct     360

gca                                                                   363


<210> 30
<211> 339
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 2.2 light chain variable
      region

<400> 30
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact      60

ctgagctgca agtccagtca gagcctttta tatagtaaca atcaaaagaa ctacttggcc     120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg     180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc     240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttataactat     300

cccacgttcg gaggggggac caagctggaa ataaaacgg                            339


<210> 31
<211> 336
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 3.1 heavy chain variable
      region

<400> 31
caggttcaac tgcagcagtc tggggctgag ctggtgaggc ctggggcttc agtgaagctg      60

tcctgcaagg ctttgggcta catatttact gactatgaaa tgcactgggt gaagcagaca     120

cctgtacatg gcctggaatg gattggagtt attcatccag gaagtggtaa tactgtctac     180

aatcagaagt tccagggcaa ggccacactg actgcagaca aatcctccag cacagcctac     240

atggaggtca gcagcctgac atctgaggac tctgctgtct attactgtaa tctatgggga     300

aggtggggcc aaggcaccac tctcacagtc tcctca                               336


<210> 32
<211> 339
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 3.1 light chain variable
      region

<400> 32
gatgttgtga tgacccagac tccagtcact ttgtcggtta acattggaca accagcctcc      60

atctcttgca agtcaggtca gagcctctta catagtgatg gaaagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc tgatctggac     180

tctggagtcc ctgacaggtt cactagcagt ggatcaggga cagatttcac actggaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acatcttccg     300

catacgttcg gaggggggac caagctggaa ataaaacgg                            339


<210> 33
<211> 342
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 3.2 heavy chain variable
      region

<400> 33
caggttcaac tgcagcagtc tggggctgag ctggtgaggc ctggggcttc agtgaagctg      60

tcctgcaagg ctttgggcta cacatttact gactatgaaa tgttctgggt gaagcagaca     120

cctgtgcatg gcctggaatg tattggaact attcatccag gaagtggtgg aactgcctac     180

aatcagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac     240

atggagctca gcagcctgac gtctgaggac tctgctgtct attactgtac aagaaatgac     300

agaggctcct ggggccaagg caccactctc acagtctcct ca                        342


<210> 34
<211> 339
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of anti-PA(S) MAb 3.2 light chain variable
      region

<400> 34
gatgttgtgc tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc      60

atctcttgca ggtcaagtca gagcctctta aatagtgatg ggaagacatt tttgaattgg     120

ttgttacaga ggccaggcct gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct     300

cacacgttcg gaggggggac caagctggaa ataaaacgg                            339


<210> 35
<211> 10
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.1 CDRH1

<400> 35
Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn 
1               5                   10  

<210> 36
<211> 16
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.1 CDRH2

<400> 36
Met Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      



<210> 37
<211> 12
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.1 CDRH3

<400> 37
Asp Tyr Tyr Gly Arg Arg Tyr Tyr Ala Met Asp Tyr 
1               5                   10          

<210> 38
<211> 15
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.1 CDRL1

<400> 38
Arg Ala Ser Lys Ser Val Ser Ser Ser Gly Tyr Asn Tyr Met Phe 
1               5                   10                  15  

<210> 39
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.1 CDRL2

<400> 39
Leu Ala Ser Asn Leu Glu Ser 
1               5           

<210> 40
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.1 CDRL3

<400> 40
Gln His Ser Arg Glu Leu Pro Leu Thr 
1               5                   

<210> 41
<211> 10
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.2 CDRH1

<400> 41
Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser 
1               5                   10  

<210> 42
<211> 17
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.2 CDRH2

<400> 42
Thr Ile Asn Ser Asn Gly Gly Ser Thr Tyr Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 43
<211> 14
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.2 CDRH3

<400> 43
Gly Gly Ser Ile Tyr Asp Gly Tyr Asp Tyr Ala Met Asp Tyr 
1               5                   10                  

<210> 44
<211> 15
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.2 CDRL1

<400> 44
Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  

<210> 45
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.2 CDRL2

<400> 45
Tyr Ala Ser Asn Leu Glu Ser 
1               5           

<210> 46
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 1.2 CDRL3

<400> 46
Gln His Ser Trp Glu Ile Pro Leu Thr 
1               5                   

<210> 47
<211> 12
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.1 CDRH1

<400> 47
Gly Phe Ser Leu Ser Thr Tyr Asp Met Gly Val Gly 
1               5                   10          

<210> 48
<211> 16
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.1 CDRH2

<400> 48
Asn Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      



<210> 49
<211> 11
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.1 CDRH3

<400> 49
Met Arg Asp Asn Tyr Gly Val Trp Phe Ala Phe 
1               5                   10      

<210> 50
<211> 17
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.1 CDRL1

<400> 50
Lys Ser Ser Gln Ser Leu Phe Tyr Ser Asn Arg Glu Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 51
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.1 CDRL2

<400> 51
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 52
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.1 CDRL3

<400> 52
Gln Gln Tyr Tyr Asn Tyr Pro Thr 
1               5               

<210> 53
<211> 12
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.2 CDRH1

<400> 53
Gly Phe Ser Leu Asn Thr Tyr Gly Met Gly Val Gly 
1               5                   10          

<210> 54
<211> 16
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.2 CDRH2

<400> 54
Asn Ile Trp Trp Thr Asp Asp Lys Tyr Tyr Asn Ser Val Leu Lys Ser 
1               5                   10                  15      



<210> 55
<211> 11
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.2 CDRH3

<400> 55
Leu Ala Tyr His Asp Asn Pro Trp Phe Ala Tyr 
1               5                   10      

<210> 56
<211> 17
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.2 CDRL1

<400> 56
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 57
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.2 CDRL2

<400> 57
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 58
<211> 8
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 2.2 CDRL3

<400> 58
Gln Gln Tyr Tyr Asn Tyr Pro Thr 
1               5               

<210> 59
<211> 10
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.1 CDRH1

<400> 59
Gly Tyr Ile Phe Thr Asp Tyr Glu Met His 
1               5                   10  

<210> 60
<211> 17
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.1 CDRH2

<400> 60
Val Ile His Pro Gly Ser Gly Asn Thr Val Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 61
<400> 61
000

<210> 62
<211> 16
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.1 CDRL1

<400> 62
Lys Ser Gly Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 63
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.1 CDRL2

<400> 63
Leu Val Ser Asp Leu Asp Ser 
1               5           

<210> 64
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.1 CDRL3

<400> 64
Trp Gln Gly Thr His Leu Pro His Thr 
1               5                   

<210> 65
<211> 10
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.2 CDRH1

<400> 65
Gly Tyr Thr Phe Thr Asp Tyr Glu Met Phe 
1               5                   10  

<210> 66
<211> 17
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.2 CDRH2

<400> 66
Thr Ile His Pro Gly Ser Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 67
<211> 5
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.2 CDRH3

<400> 67
Asn Asp Arg Gly Ser 
1               5   

<210> 68
<211> 16
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.2 CDRL1

<400> 68
Arg Ser Ser Gln Ser Leu Leu Asn Ser Asp Gly Lys Thr Phe Leu Asn 
1               5                   10                  15      



<210> 69
<211> 7
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.2 CDRL2

<400> 69
Leu Val Ser Lys Leu Asp Ser 
1               5           

<210> 70
<211> 9
<212> PRT
<213> Mus musculus


<220> 
<223> Amino acid sequence of anti-PA(S) MAb 3.2 CDRL3

<400> 70
Trp Gln Gly Thr His Phe Pro His Thr 
1               5                   

<210> 71
<211> 450
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of StrepII-eGFP-PAS#1(200)

<400> 71
Ala Ser Trp Ser His Pro Gln Phe Glu Lys Gly Ala Ser Lys Gly Glu 
1               5                   10                  15      
Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
            20                  25                  30          
Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
        35                  40                  45              
Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
    50                  55                  60                  
Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln 
65                  70                  75                  80  
Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg His Asp Phe Phe Lys 
                85                  90                  95      
Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
            100                 105                 110         
Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
        115                 120                 125             
Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
    130                 135                 140                 
Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
145                 150                 155                 160 
Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
                165                 170                 175     
Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            180                 185                 190         
Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        195                 200                 205             
Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
    210                 215                 220                 
Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
225                 230                 235                 240 
Thr His Gly Met Asp Glu Leu Tyr Gln Ala Ser Pro Ala Ala Pro Ala 
                245                 250                 255     
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
            260                 265                 270         
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
        275                 280                 285             
Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
    290                 295                 300                 
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
305                 310                 315                 320 
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
                325                 330                 335     
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
            340                 345                 350         
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
        355                 360                 365             
Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
    370                 375                 380                 
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
385                 390                 395                 400 
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
                405                 410                 415     
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
            420                 425                 430         
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
        435                 440                 445             
Ala Ala 
    450 

<210> 72
<211> 364
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of PAS#1(200)-IL1Ra

<400> 72
Met Lys His His His His His His Ser Ser Ser Ala Ser Pro Ala Ala 
1               5                   10                  15      
Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala 
            20                  25                  30          
Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser 
        35                  40                  45              
Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala 
    50                  55                  60                  
Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala 
65                  70                  75                  80  
Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala 
                85                  90                  95      
Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala 
            100                 105                 110         
Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser 
        115                 120                 125             
Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala 
    130                 135                 140                 
Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala 
145                 150                 155                 160 
Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala 
                165                 170                 175     
Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala 
            180                 185                 190         
Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser 
        195                 200                 205             
Ala Pro Ala Ala Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
    210                 215                 220                 
Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
225                 230                 235                 240 
Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
                245                 250                 255     
Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
            260                 265                 270         
His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
        275                 280                 285             
Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
    290                 295                 300                 
Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
305                 310                 315                 320 
Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala 
                325                 330                 335     
Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
            340                 345                 350         
Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        355                 360                 

<210> 73
<211> 364
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of P/A#1(200)-IL1Ra

<400> 73
Met Lys His His His His His His Ser Ser Ser Ala Ala Pro Ala Ala 
1               5                   10                  15      
Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala 
            20                  25                  30          
Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala 
        35                  40                  45              
Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala 
    50                  55                  60                  
Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala 
65                  70                  75                  80  
Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala 
                85                  90                  95      
Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala 
            100                 105                 110         
Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala 
        115                 120                 125             
Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala 
    130                 135                 140                 
Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala 
145                 150                 155                 160 
Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala 
                165                 170                 175     
Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala 
            180                 185                 190         
Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala 
        195                 200                 205             
Ala Pro Ala Ala Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala 
    210                 215                 220                 
Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
225                 230                 235                 240 
Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
                245                 250                 255     
Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile 
            260                 265                 270         
His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr 
        275                 280                 285             
Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg 
    290                 295                 300                 
Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr 
305                 310                 315                 320 
Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala 
                325                 330                 335     
Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly 
            340                 345                 350         
Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
        355                 360                 

<210> 74
<211> 353
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of APSA(200)-IL1Ra

<400> 74
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
1               5                   10                  15      
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
            20                  25                  30          
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
        35                  40                  45              
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
    50                  55                  60                  
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
65                  70                  75                  80  
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
                85                  90                  95      
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
            100                 105                 110         
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
        115                 120                 125             
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
    130                 135                 140                 
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
145                 150                 155                 160 
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
                165                 170                 175     
Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala Ala Pro Ser Ala 
            180                 185                 190         
Ala Pro Ser Ala Ala Pro Ser Ala Ala Arg Pro Ser Gly Arg Lys Ser 
        195                 200                 205             
Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
    210                 215                 220                 
Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
225                 230                 235                 240 
Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
                245                 250                 255     
Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
            260                 265                 270         
Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
        275                 280                 285             
Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
    290                 295                 300                 
Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
305                 310                 315                 320 
Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
                325                 330                 335     
Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
            340                 345                 350         
Glu 
    

<210> 75
<211> 736
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of P/A#1(600)-GMCSF

<400> 75
His His His His His His Ser Ser Ser Ala Ala Pro Ala Ala Pro Ala 
1               5                   10                  15      
Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro 
            20                  25                  30          
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
        35                  40                  45              
Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
    50                  55                  60                  
Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala 
                85                  90                  95      
Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro 
            100                 105                 110         
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
        115                 120                 125             
Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
    130                 135                 140                 
Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
145                 150                 155                 160 
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala 
                165                 170                 175     
Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro 
            180                 185                 190         
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
        195                 200                 205             
Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
    210                 215                 220                 
Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
225                 230                 235                 240 
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala 
                245                 250                 255     
Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro 
            260                 265                 270         
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
        275                 280                 285             
Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
    290                 295                 300                 
Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
305                 310                 315                 320 
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala 
                325                 330                 335     
Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro 
            340                 345                 350         
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
        355                 360                 365             
Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
    370                 375                 380                 
Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
385                 390                 395                 400 
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala 
                405                 410                 415     
Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro 
            420                 425                 430         
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
        435                 440                 445             
Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
    450                 455                 460                 
Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
465                 470                 475                 480 
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala 
                485                 490                 495     
Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro 
            500                 505                 510         
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
        515                 520                 525             
Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala 
    530                 535                 540                 
Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
545                 550                 555                 560 
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro Ala Ala Pro Ala 
                565                 570                 575     
Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Ala Pro 
            580                 585                 590         
Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro 
        595                 600                 605             
Ala Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
    610                 615                 620                 
Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
625                 630                 635                 640 
Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
                645                 650                 655     
Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
            660                 665                 670         
Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
        675                 680                 685             
Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
    690                 695                 700                 
Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
705                 710                 715                 720 
Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
                725                 730                 735     



<210> 76
<211> 629
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> ACETYLATION

<220> 
<223> Amino acid sequence of PASylated Thymosin-alpha1, N-terminally
      acetylated

<400> 76
Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr Lys Asp Leu 
1               5                   10                  15      
Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn Ala Ser Pro Ala 
            20                  25                  30          
Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
        35                  40                  45              
Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
    50                  55                  60                  
Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
65                  70                  75                  80  
Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
                85                  90                  95      
Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
            100                 105                 110         
Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
        115                 120                 125             
Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
    130                 135                 140                 
Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
145                 150                 155                 160 
Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
                165                 170                 175     
Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
            180                 185                 190         
Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
        195                 200                 205             
Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
    210                 215                 220                 
Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
225                 230                 235                 240 
Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
                245                 250                 255     
Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
            260                 265                 270         
Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
        275                 280                 285             
Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
    290                 295                 300                 
Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
305                 310                 315                 320 
Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
                325                 330                 335     
Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
            340                 345                 350         
Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
        355                 360                 365             
Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
    370                 375                 380                 
Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
385                 390                 395                 400 
Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
                405                 410                 415     
Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
            420                 425                 430         
Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
        435                 440                 445             
Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
    450                 455                 460                 
Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
465                 470                 475                 480 
Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
                485                 490                 495     
Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
            500                 505                 510         
Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
        515                 520                 525             
Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
    530                 535                 540                 
Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
545                 550                 555                 560 
Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
                565                 570                 575     
Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
            580                 585                 590         
Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
        595                 600                 605             
Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
    610                 615                 620                 
Ser Ala Pro Ala Ala 
625                 

<210> 77
<211> 18
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of Primer RMK

<400> 77
gacctccacg gagtcagc                                                  18


<210> 78
<211> 18
<212> DNA
<213> Mus musculus


<220> 
<223> Nucleotide sequence of Primer RMG

<400> 78
aggtcgccac acgtgtgg                                                  18


<210> 79
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope PSAAPS

<400> 79
Pro Ser Ala Ala Pro Ser 
1               5       

<210> 80
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope ASPAAP

<400> 80
Ala Ser Pro Ala Ala Pro 
1               5       

<210> 81
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope PASPAA

<400> 81
Pro Ala Ser Pro Ala Ala 
1               5       

<210> 82
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope PAAP

<400> 82
Pro Ala Ala Pro 
1               

<210> 83
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope PASP

<400> 83
Pro Ala Ser Pro 
1               

<210> 84
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope APSA

<400> 84
Ala Pro Ser Ala 
1               

<210> 85
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope PSAA

<400> 85
Pro Ser Ala Ala 
1               

<210> 86
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope ASPA

<400> 86
Ala Ser Pro Ala 
1               

<210> 87
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope APAP

<400> 87
Ala Pro Ala Pro 
1               

<210> 88
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope SAPA

<400> 88
Ser Ala Pro Ala 
1               

<210> 89
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence for epitope AAPA

<400> 89
Ala Ala Pro Ala 
1               

<210> 90
<211> 388
<212> PRT
<213> Artificial Sequence


<220> 
<223> H1GA-PAS#1(200)-His6

<400> 90
Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Ala Ala Gly Asn Val Leu Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Leu Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Ser Val Gly Phe Asp Asp Lys Lys Cys Leu Tyr Lys Ile 
65                  70                  75                  80  
Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Arg 
                85                  90                  95      
Ile Lys Ser Glu Pro Gly Gly Thr Ser Trp Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Glu Val Ala Gln 
        115                 120                 125             
Asn Arg Glu Thr Phe Asn Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly Ser Ser Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
            180                 185                 190         
Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
        195                 200                 205             
Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
    210                 215                 220                 
Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
225                 230                 235                 240 
Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
                245                 250                 255     
Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
            260                 265                 270         
Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
        275                 280                 285             
Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
    290                 295                 300                 
Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
305                 310                 315                 320 
Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
                325                 330                 335     
Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
            340                 345                 350         
Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
        355                 360                 365             
Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ser Ala His His 
    370                 375                 380                 
His His His His 
385             

<210> 91
<211> 954
<212> PRT
<213> Artificial Sequence


<220> 
<223> PAS#1(800)-IL1Ra

<400> 91
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
1               5                   10                  15      
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
            20                  25                  30          
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
        35                  40                  45              
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
    50                  55                  60                  
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
65                  70                  75                  80  
Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
                85                  90                  95      
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
            100                 105                 110         
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
        115                 120                 125             
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
    130                 135                 140                 
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
145                 150                 155                 160 
Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
                165                 170                 175     
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
            180                 185                 190         
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
        195                 200                 205             
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
    210                 215                 220                 
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
225                 230                 235                 240 
Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
                245                 250                 255     
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
            260                 265                 270         
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
        275                 280                 285             
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
    290                 295                 300                 
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
305                 310                 315                 320 
Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
                325                 330                 335     
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
            340                 345                 350         
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
        355                 360                 365             
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
    370                 375                 380                 
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
385                 390                 395                 400 
Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
                405                 410                 415     
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
            420                 425                 430         
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
        435                 440                 445             
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
    450                 455                 460                 
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
465                 470                 475                 480 
Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
                485                 490                 495     
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
            500                 505                 510         
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
        515                 520                 525             
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
    530                 535                 540                 
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
545                 550                 555                 560 
Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
                565                 570                 575     
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
            580                 585                 590         
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
        595                 600                 605             
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
    610                 615                 620                 
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
625                 630                 635                 640 
Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
                645                 650                 655     
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
            660                 665                 670         
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
        675                 680                 685             
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
    690                 695                 700                 
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
705                 710                 715                 720 
Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala 
                725                 730                 735     
Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro 
            740                 745                 750         
Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala 
        755                 760                 765             
Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro 
    770                 775                 780                 
Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro 
785                 790                 795                 800 
Ala Ala Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg 
                805                 810                 815     
Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu 
            820                 825                 830         
Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile 
        835                 840                 845             
Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly 
    850                 855                 860                 
Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu 
865                 870                 875                 880 
Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln 
                885                 890                 895     
Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser 
            900                 905                 910         
Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu 
        915                 920                 925             
Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met 
    930                 935                 940                 
Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
945                 950                 

<210> 92
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> Heavy chain PASylated humanized anti-Galectin-3 Fab

<400> 92
Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Ala Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Gln Val Ile Ile Ser Leu Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Thr Met Met Ala Ser Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys His His His 
    210                 215                 220                 
His His His 
225         

<210> 93
<211> 420
<212> PRT
<213> Artificial Sequence


<220> 
<223> Light chain PASylated humanized anti-Galectin-3 Fab

<400> 93
Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Ser Trp Ile Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              
Pro Lys Gly Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Trp Gln Ala 
                85                  90                  95      
Thr His Phe Pro Leu Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Ala Ser Pro Ala Ala 
    210                 215                 220                 
Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala 
225                 230                 235                 240 
Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser 
                245                 250                 255     
Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala 
            260                 265                 270         
Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala 
        275                 280                 285             
Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala 
    290                 295                 300                 
Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala 
305                 310                 315                 320 
Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser 
                325                 330                 335     
Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala 
            340                 345                 350         
Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala 
        355                 360                 365             
Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala 
    370                 375                 380                 
Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala 
385                 390                 395                 400 
Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser 
                405                 410                 415     
Ala Pro Ala Ala 
            420 

<210> 94
<211> 259
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human Galectin-3 C173T C-terminally fused with Strep-tagII

<400> 94
Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn Pro 
1               5                   10                  15      
Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly Ala 
            20                  25                  30          
Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln Ala 
        35                  40                  45              
Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly 
    50                  55                  60                  
Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro Gly 
65                  70                  75                  80  
Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser Ala 
                85                  90                  95      
Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly Pro 
            100                 105                 110         
Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg 
        115                 120                 125             
Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile 
    130                 135                 140                 
Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro 
145                 150                 155                 160 
Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Thr Asn Thr Lys Leu 
                165                 170                 175     
Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu 
            180                 185                 190         
Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His Phe 
        195                 200                 205             
Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Val 
    210                 215                 220                 
Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp 
225                 230                 235                 240 
Leu Thr Ser Ala Ser Tyr Thr Met Ile Ser Ala Trp Ser His Pro Gln 
                245                 250                 255     
Phe Glu Lys 
            

