                         SEQUENCE LISTING

<110>  Cantargia AB
 
<120>  Anti-IL1RAP antibody

<130>  CANBG/P79764PC

<150> EP20216926.4
<151> 2020-12-23

<150> GB2105933.2
<151> 2021-04-26

<150> EP21212368.1
<151> 2021-12-03

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  CDR-L1 according to IMGT

<400>  1

Glu Ser Ile Ser Thr Ala 
1               5       


<210>  2
<211>  329
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(329)
<223>  Immunoglobulin IgG1 constant heavy chain with LALA mutation

<400>  2

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  3
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  CDR-L3 according to IMGT

<400>  3

Gln Gln Gly Phe Ser Ser Gly Asn Val His Asn Ala 
1               5                   10          


<210>  4
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  CDR-H1 according to IMGT

<400>  4

Gly Pro Ser Leu Ser His Phe Asp 
1               5               


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  CDR-H2 according to IMGT

<400>  5

Ile Ser Pro Gly Val Ser Thr 
1               5           


<210>  6
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR-H3 according to IMGT

<400>  6

Ala Arg Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu 
1               5                   10                  


<210>  7
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  CDR-L1 according to Kabat

<400>  7

Gln Ala Ser Glu Ser Ile Ser Thr Ala Leu Ala 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  CDR-L2 according to Kabat

<400>  8

Lys Ala Ser Thr Leu Pro Ser 
1               5           


<210>  9
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  CDR-L3 according to Kabat

<400>  9

Gln Gln Gly Phe Ser Ser Gly Asn Val His Asn Ala 
1               5                   10          


<210>  10
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR-H1 according to Kabat

<400>  10

His Phe Asp Ile Thr 
1               5   


<210>  11
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CDR-H2 according to Kabat

<400>  11

Thr Ile Ser Pro Gly Val Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      


<210>  12
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  CDR-H3 according to Kabat

<400>  12

Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu 
1               5                   10          


<210>  13
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  CDR-L1 according to combination of IMGT and Kabat

<400>  13

Gln Ala Ser Glu Ser Ile Ser Thr Ala Leu Ala 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  CDR-L2 according to combination of IMGT and Kabat

<400>  14

Lys Ala Ser Thr Leu Pro Ser 
1               5           


<210>  15
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)

<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  CDR-L3 according to combination of IMGT and Kabat

<400>  15

Gln Gln Gly Phe Ser Ser Gly Asn Val His Asn Ala 
1               5                   10          


<210>  16
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR-H1 according to combination of IMGT and Kabat

<400>  16

Gly Pro Ser Leu Ser His Phe Asp Ile Thr 
1               5                   10  


<210>  17
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CDR-H2 according to combination of IMGT and Kabat

<400>  17

Thr Ile Ser Pro Gly Val Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      


<210>  18
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR-H3 according to combination of IMGT and Kabat

<400>  18

Ala Arg Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu 
1               5                   10                  


<210>  19
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Light chain variable region (non-humanized, non-deimmunized)

<400>  19

Ala Pro Val Leu Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Pro Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ala Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser Ser Gly Asn 
                85                  90                  95      


Val His Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  20
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Heavy chain variable region (non-humanized, non-deimmunized)

<400>  20

Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Val Ser Gly Pro Ser Leu Ser His Phe 
            20                  25                  30          


Asp Ile Thr Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Ser Pro Gly Val Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Ser Thr Ile Thr Ser Asn Thr Asn Leu Asn Thr Val Thr Leu 
65                  70                  75                  80  


Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Ile Ser Ser 
        115                 120 


<210>  21
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Humanized light chain variable region VL1

<400>  21

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser Ser Gly Asn 
                85                  90                  95      


Val His Asn Ala Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  22
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Humanized light chain variable region VL2

<400>  22

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser Ser Gly Asn 
                85                  90                  95      


Val His Asn Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  23
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Humanized light chain variable region VL3

<400>  23

Asp Ile Leu Leu Thr Gln Thr Pro Ser Val Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser Ser Gly Asn 
                85                  90                  95      


Val His Asn Ala Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110 


<210>  24
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Humanized light chain variable region VL4

<400>  24

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser Ser Gly Asn 
                85                  90                  95      


Val His Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  25
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Humanized light chain variable region VL5

<400>  25

Ala Pro Val Leu Thr Gln Ser Pro Ala Thr Leu Glu Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser Ser Gly Asn 
                85                  90                  95      


Val His Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  26
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Humanized heavy chain variable region VH1

<400>  26

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Leu Ser His Phe 
            20                  25                  30          


Asp Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Pro Gly Val Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  27
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Humanized heavy chain variable region VH2

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Val Ser Gly Pro Ser Leu Ser His Phe 
            20                  25                  30          


Asp Ile Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Pro Gly Val Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Thr Asp Thr Ser Lys Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  28
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Humanized heavy chain variable region VH3

<400>  28

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Leu Ser His Phe 
            20                  25                  30          


Asp Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Pro Gly Val Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu Trp Gly Leu 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  29
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Humanized heavy chain variable region VH4

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Pro Ser Leu Ser His Phe 
            20                  25                  30          


Asp Ile Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Ser Pro Gly Val Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Humanized heavy chain variable region VH5

<400>  30

Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Pro Ser Leu Ser His Phe 
            20                  25                  30          


Asp Ile Thr Trp Ile Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Ser Pro Gly Val Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Leu Asn Thr Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Ile Ser Ser 
        115                 120 


<210>  31
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Humanized and de-immunized VL5.GL

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser Ser Gly Asn 
                85                  90                  95      


Val His Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  32
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Humanized and de-immunized VH5.AP

<400>  32

Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Pro Ser Leu Ser His Phe 
            20                  25                  30          


Asp Ile Thr Trp Ile Arg Gln Pro Pro Gly Ser Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Ser Pro Gly Val Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Leu Asn Thr Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Ile Ser Ser 
        115                 120 


<210>  33
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Humanized and de-immunized VH5.SK

<400>  33

Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Pro Ser Leu Ser His Phe 
            20                  25                  30          


Asp Ile Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Ser Pro Gly Val Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Leu Asn Thr Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Ile Ser Ser 
        115                 120 


<210>  34
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Humanized and de-immunized VH5.GL

<400>  34

Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Pro Ser Leu Ser His Phe 
            20                  25                  30          


Asp Ile Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Ser Pro Gly Val Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Leu Asn Thr Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Val Gly Ser Ser Trp Lys Ala Phe Asp Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Ile Ser Ser 
        115                 120 


<210>  35
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Immunoglobulin kappa constant light chain

<400>  35

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  36
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(330)
<223>  Immunoglobulin IgG1 constant heavy chain

<400>  36

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  37
<211>  356
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(356)
<223>  Full-length human IL1RAP

<400>  37

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Gly Asn 
            340                 345                 350         


Arg Cys Gly Gln 
        355     


<210>  38
<211>  101
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(101)
<223>  Domain 2 of IL1RAP

<400>  38

Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu Pro Val His Lys Leu 
1               5                   10                  15      


Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys Pro Asn Val Asp Gly 
            20                  25                  30          


Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr Trp Tyr Met Gly Cys 
        35                  40                  45              


Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro Glu Gly Met Asn Leu 
    50                  55                  60                  


Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly Asn Tyr Thr Cys Val 
65                  70                  75                  80  


Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His Leu Thr Arg Thr Leu 
                85                  90                  95      


Thr Val Lys Val Val 
            100     


<210>  39
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  H2 region of domain 2 of human IL1RAP

<400>  39

Thr Ile Thr Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn 
1               5                   10                  15      


Val Ile 
        


