                         SEQUENCE LISTING

<110>  Inserm
 
<120>  CHLAMYDIA VACCINE BASED ON TARGETING MOMP VS4 ANTIGEN TO ANTIGEN 
       PRESENTING CELLS

<130>  BIO20450 LEVY / MC

<160>  45    

<170>  PatentIn version 3.3

<210>  1
<211>  393
<212>  PRT
<213>  Chlamydia trachomatis

<400>  1

Met Lys Lys Leu Leu Lys Ser Val Leu Val Phe Ala Ala Leu Ser Ser 
1               5                   10                  15      


Ala Ser Ser Leu Gln Ala Leu Pro Val Gly Asn Pro Ala Glu Pro Ser 
            20                  25                  30          


Leu Met Ile Asp Gly Ile Leu Trp Glu Gly Phe Gly Gly Asp Pro Cys 
        35                  40                  45              


Asp Pro Cys Ala Thr Trp Cys Asp Ala Ile Ser Met Arg Val Gly Tyr 
    50                  55                  60                  


Tyr Gly Asp Phe Val Phe Asp Arg Val Leu Lys Thr Asp Val Asn Lys 
65                  70                  75                  80  


Glu Phe Gln Met Gly Ala Lys Pro Thr Thr Asp Thr Gly Asn Ser Ala 
                85                  90                  95      


Ala Pro Ser Thr Leu Thr Ala Arg Glu Asn Pro Ala Tyr Gly Arg His 
            100                 105                 110         


Met Gln Asp Ala Glu Met Phe Thr Asn Ala Ala Cys Met Ala Leu Asn 
        115                 120                 125             


Ile Trp Asp Arg Phe Asp Val Phe Cys Thr Leu Gly Ala Thr Ser Gly 
    130                 135                 140                 


Tyr Leu Lys Gly Asn Ser Ala Ser Phe Asn Leu Val Gly Leu Phe Gly 
145                 150                 155                 160 


Asp Asn Glu Asn Gln Lys Thr Val Lys Ala Glu Ser Val Pro Asn Met 
                165                 170                 175     


Ser Phe Asp Gln Ser Val Val Glu Leu Tyr Thr Asp Thr Thr Phe Ala 
            180                 185                 190         


Trp Ser Val Gly Ala Arg Ala Ala Leu Trp Glu Cys Gly Cys Ala Thr 
        195                 200                 205             


Leu Gly Ala Ser Phe Gln Tyr Ala Gln Ser Lys Pro Lys Val Glu Glu 
    210                 215                 220                 


Leu Asn Val Leu Cys Asn Ala Ala Glu Phe Thr Ile Asn Lys Pro Lys 
225                 230                 235                 240 


Gly Tyr Val Gly Lys Glu Phe Pro Leu Asp Leu Thr Ala Gly Thr Asp 
                245                 250                 255     


Ala Ala Thr Gly Thr Lys Asp Ala Ser Ile Asp Tyr His Glu Trp Gln 
            260                 265                 270         


Ala Ser Leu Ala Leu Ser Tyr Arg Leu Asn Met Phe Thr Pro Tyr Ile 
        275                 280                 285             


Gly Val Lys Trp Ser Arg Ala Ser Phe Asp Ala Asp Thr Ile Arg Ile 
    290                 295                 300                 


Ala Gln Pro Lys Ser Ala Thr Ala Ile Phe Asp Thr Thr Thr Leu Asn 
305                 310                 315                 320 


Pro Thr Ile Ala Gly Ala Gly Asp Val Lys Thr Gly Ala Glu Gly Gln 
                325                 330                 335     


Leu Gly Asp Thr Met Gln Ile Val Ser Leu Gln Leu Asn Lys Met Lys 
            340                 345                 350         


Ser Arg Lys Ser Cys Gly Ile Ala Val Gly Thr Thr Ile Val Asp Ala 
        355                 360                 365             


Asp Lys Tyr Ala Val Thr Val Glu Thr Arg Leu Ile Asp Glu Arg Ala 
    370                 375                 380                 


Ala His Val Asn Ala Gln Phe Arg Phe 
385                 390             


<210>  2
<211>  149
<212>  PRT
<213>  Artificial

<220>
<223>  CD40L binding domain

<400>  2

Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
1               5                   10                  15      


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
        35                  40                  45              


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
    50                  55                  60                  


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
65                  70                  75                  80  


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
                85                  90                  95      


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
            100                 105                 110         


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
        115                 120                 125             


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
    130                 135                 140                 


Gly Leu Leu Lys Leu 
145                 


<210>  3
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR1

<400>  3

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Tyr 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR2

<400>  4

Tyr Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR3

<400>  5

Arg Gly Leu Pro Phe His Ala Met Asp Tyr 
1               5                   10  


<210>  6
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR1

<400>  6

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR2

<400>  7

Tyr Thr Ser Ile Leu His Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR3

<400>  8

Gln Gln Phe Asn Lys Leu Pro Pro Thr 
1               5                   


<210>  9
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR1

<400>  9

Gly Tyr Ser Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210>  10
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR2

<400>  10

Arg Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  11
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR3

<400>  11

Glu Asp Tyr Val Tyr 
1               5   


<210>  12
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR1

<400>  12

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR2

<400>  13

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR3

<400>  14

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  15
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR1

<400>  15

Gly Tyr Thr Phe Thr Asp Tyr Val Leu His 
1               5                   10  


<210>  16
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR2

<400>  16

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR3

<400>  17

Gly Tyr Pro Ala Tyr Ser Gly Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  18
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR1

<400>  18

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR2

<400>  19

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR3

<400>  20

His His Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  21
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  21

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Val Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser 
        115     


<210>  22
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  22

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
            100                 105             


<210>  23
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  23

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Val Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser 
        115     


<210>  24
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  24

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Leu His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Pro Ala Tyr Ser Gly Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser 
        115                 120             


<210>  25
<211>  103
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  25

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys His His Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  26
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  26

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Phe Tyr Tyr Gly Tyr Ser Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser 
        115                 120     


<210>  27
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  27

Gln Ile Val Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys 
            100         


<210>  28
<211>  128
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


<210>  29
<211>  103
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  30
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Pro Phe His Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120     


<210>  31
<211>  103
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Lys Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  32
<211>  81
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  32

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
1               5                   10                  15      


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
            20                  25                  30          


Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn Phe 
        35                  40                  45              


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
    50                  55                  60                  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
65                  70                  75                  80  


Ala 
    


<210>  33
<211>  76
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  33

Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly 
1               5                   10                  15      


Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys 
            20                  25                  30          


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
        35                  40                  45              


Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile Ser Arg 
    50                  55                  60                  


Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser 
65                  70                  75      


<210>  34
<211>  82
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  34

Ser Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
1               5                   10                  15      


Tyr Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp 
            20                  25                  30          


Ile Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn 
        35                  40                  45              


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala 
    50                  55                  60                  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
65                  70                  75                  80  


Cys Ala 
        


<210>  35
<211>  74
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  35

Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn 
1               5                   10                  15      


Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu 
            20                  25                  30          


Ile Gly Gly Thr Asn Asn Arg Val Ser Gly Val Pro Ala Arg Phe Ser 
        35                  40                  45              


Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln 
    50                  55                  60                  


Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala 
65                  70                  


<210>  36
<211>  456
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  36

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asp His 
            20                  25                  30          


Asp Met His Trp Val Gln Gln Thr Pro Val Tyr Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Pro Phe Tyr Tyr Ser Asn Tyr Ser Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Ala Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Val Cys Gly Gly Thr Thr Gly Ser Ser Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Leu Leu Gln Ser Gly Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
            180                 185                 190         


Ser Asn Thr Trp Pro Ser Gln Thr Ile Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Val Pro Ile 
    210                 215                 220                 


Thr Gln Asn Pro Cys Pro Pro Leu Lys Glu Cys Pro Pro Cys Ala Asp 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
                245                 250                 255     


Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Glu Asp Asp Pro Asp Ala Gln Ile Ser Trp Phe Val Asn Asn 
        275                 280                 285             


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
    290                 295                 300                 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
305                 310                 315                 320 


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg Ala 
            340                 345                 350         


Pro Gln Val Tyr Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys 
        355                 360                 365             


Glu Phe Ser Leu Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile 
    370                 375                 380                 


Ala Val Asp Trp Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn 
385                 390                 395                 400 


Thr Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
                405                 410                 415     


Leu Arg Val Gln Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys 
            420                 425                 430         


Ser Val Val His Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile 
        435                 440                 445             


Ser Arg Ser Leu Gly Lys Ala Ser 
    450                 455     


<210>  37
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  37

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Arg Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  38
<211>  325
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein comprising the VS4 polypeptide

<400>  38

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Ser Arg Gly Leu Asn Asp Ile Phe 
            20                  25                  30          


Glu Ala Gln Lys Ile Glu Trp His Glu Thr Ser Asp Asp Leu Asp Ala 
        35                  40                  45              


Val Arg Ile Lys Val Asp Thr Val Asn Ala Lys Pro Gly Asp Thr Val 
    50                  55                  60                  


Arg Ile Pro Val Arg Phe Ser Gly Ile Pro Ser Lys Gly Ile Ala Asn 
65                  70                  75                  80  


Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn Val Leu Glu Ile Ile Glu 
                85                  90                  95      


Ile Glu Pro Gly Asp Ile Ile Val Asp Pro Asn Pro Asp Lys Ser Phe 
            100                 105                 110         


Asp Thr Ala Val Tyr Pro Asp Arg Lys Ile Ile Val Phe Leu Phe Ala 
        115                 120                 125             


Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile Thr Lys Asp Gly Val Phe 
    130                 135                 140                 


Ala Thr Ile Val Ala Lys Val Lys Glu Gly Ala Pro Asn Gly Leu Ser 
145                 150                 155                 160 


Val Ile Lys Phe Val Glu Val Gly Gly Phe Ala Asn Asn Asp Leu Val 
                165                 170                 175     


Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly Val Asn Val Gly Asp Thr 
            180                 185                 190         


Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr Thr Pro Thr Thr Thr 
        195                 200                 205             


Asp Asp Leu Asp Ala Ile Asp Gln Thr Pro Thr Asn Thr Ile Ser Val 
    210                 215                 220                 


Thr Pro Thr Asn Asn Ser Thr Pro Thr Asn Asn Ser Asn Pro Lys Pro 
225                 230                 235                 240 


Asn Pro Ala Ser Asn Met Phe Thr Pro Tyr Ile Gly Val Lys Trp Ser 
                245                 250                 255     


Arg Ala Ser Phe Asp Ala Asp Thr Ile Arg Ile Ala Gln Pro Lys Ser 
            260                 265                 270         


Ala Thr Ala Ile Phe Asp Thr Thr Thr Leu Asn Pro Thr Ile Ala Gly 
        275                 280                 285             


Ala Gly Asp Val Lys Thr Gly Ala Glu Gly Gln Leu Gly Asp Thr Met 
    290                 295                 300                 


Gln Ile Val Ser Leu Gln Leu Asn Lys Met Lys Ser Arg Lys Ser Cys 
305                 310                 315                 320 


Gly Glu Pro Glu Ala 
                325 


<210>  39
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  39

Gln Thr Pro Thr Asn Thr Ile Ser Val Thr Pro Thr Asn Asn Ser Thr 
1               5                   10                  15      


Pro Thr Asn Asn Ser Asn Pro Lys Pro Asn Pro 
            20                  25          


<210>  40
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  40

Ala Ser Ser Ser Val Ser Pro Thr Thr Ser Val His Pro Thr Pro Thr 
1               5                   10                  15      


Ser Val Pro Pro Thr Pro Thr Lys Ser Ser Pro Ala Ser 
            20                  25                  


<210>  41
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  41

Pro Thr Ser Thr Pro Ala Asp Ser Ser Thr Ile Thr Pro Thr Ala Thr 
1               5                   10                  15      


Pro Thr Ala Thr Pro Thr Ile Lys Gly 
            20                  25  


<210>  42
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  42

Thr Val Thr Pro Thr Ala Thr Ala Thr Pro Ser Ala Ile Val Thr Thr 
1               5                   10                  15      


Ile Thr Pro Thr Ala Thr Thr Lys Pro 
            20                  25  


<210>  43
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  43

Thr Asn Gly Ser Ile Thr Val Ala Ala Thr Ala Pro Thr Val Thr Pro 
1               5                   10                  15      


Thr Val Asn Ala Thr Pro Ser Ala Ala 
            20                  25  


<210>  44
<211>  558
<212>  PRT
<213>  Artificial

<220>
<223>  hAnti-CD40VH3-LV-hIgG4H-C-Flex-v1- hMOMP/VS4-EPEA

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Pro Phe His Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser 
        435                 440                 445             


Gln Thr Pro Thr Asn Thr Ile Ser Val Thr Pro Thr Asn Asn Ser Thr 
    450                 455                 460                 


Pro Thr Asn Asn Ser Asn Pro Lys Pro Asn Pro Ala Ser Asn Met Phe 
465                 470                 475                 480 


Thr Pro Tyr Ile Gly Val Lys Trp Ser Arg Ala Ser Phe Asp Ala Asp 
                485                 490                 495     


Thr Ile Arg Ile Ala Gln Pro Lys Ser Ala Thr Ala Ile Phe Asp Thr 
            500                 505                 510         


Thr Thr Leu Asn Pro Thr Ile Ala Gly Ala Gly Asp Val Lys Thr Gly 
        515                 520                 525             


Ala Glu Gly Gln Leu Gly Asp Thr Met Gln Ile Val Ser Leu Gln Leu 
    530                 535                 540                 


Asn Lys Met Lys Ser Arg Lys Ser Cys Gly Glu Pro Glu Ala 
545                 550                 555             


<210>  45
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  hAnti-CD40VK2-LV-hIgG4H-C

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Lys Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


