                         SEQUENCE LISTING

<110>  Deutsches Zentrum fr Neurodegenerative Erkrankungen e. V.
 
<120>  CHIMERIC AUTOANTIBODY RECEPTOR (CAAR) COMPRISING A NICOTINIC 
       ACETYLCHOLINE RECEPTOR AUTOANTIGEN

<130>  XII 2356/20WO

<150>  EP20216515.5
<151>  2020-12-22

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile 
225                 230                 235                 240 


Pro Cys Leu Leu Phe Ser Phe Leu Thr Gly Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Thr Asp Ser Gly Glu Lys Met Thr Leu Ser Ile Ser Val Leu Leu Ser 
            260                 265                 270         


Leu Thr Val Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Thr Ser 
        275                 280                 285             


Ser Ala Val Pro Leu Ile Gly Lys Tyr Met Leu Phe Thr Met Val Phe 
    290                 295                 300                 


Val Ile Ala Ser Ile Ile Ile Thr Val Ile Val Ile Asn Thr His His 
305                 310                 315                 320 


Arg Ser Pro Ser Thr His Val Met Pro Asn Trp Val Arg Lys Val Phe 
                325                 330                 335     


Ile Asp Thr Ile Pro Asn Ile Met Phe Phe Ser Thr Met Lys Arg Pro 
            340                 345                 350         


Ser Arg Glu Lys Gln Asp Lys Lys Ile Phe Thr Glu Asp Ile Asp Ile 
        355                 360                 365             


Ser Asp Ile Ser Gly Lys Pro Gly Pro Pro Pro Met Gly Phe His Ser 
    370                 375                 380                 


Pro Leu Ile Lys His Pro Glu Val Lys Ser Ala Ile Glu Gly Ile Lys 
385                 390                 395                 400 


Tyr Ile Ala Glu Thr Met Lys Ser Asp Gln Glu Ser Asn Asn Ala Ala 
                405                 410                 415     


Ala Glu Trp Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly 
            420                 425                 430         


Val Phe Met Leu Val Cys Ile Ile Gly Thr Leu Ala Val Phe Ala Gly 
        435                 440                 445             


Arg Leu Ile Glu Leu Asn Gln Gln Gly 
    450                 455         


<210>  2
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gly Asp 
65                  70                  75                  80  


Met Val Asp Leu Pro Arg Pro Ser Cys Val Thr Leu Gly Val Pro Leu 
                85                  90                  95      


Phe Ser His Leu Gln Asn Glu Gln Trp Val Asp Tyr Asn Leu Lys Trp 
            100                 105                 110         


Asn Pro Asp Asp Tyr Gly Gly Val Lys Lys Ile His Ile Pro Ser Glu 
        115                 120                 125             


Lys Ile Trp Arg Pro Asp Leu Val Leu Tyr Asn Asn Ala Asp Gly Asp 
    130                 135                 140                 


Phe Ala Ile Val Lys Phe Thr Lys Val Leu Leu Gln Tyr Thr Gly His 
145                 150                 155                 160 


Ile Thr Trp Thr Pro Pro Ala Ile Phe Lys Ser Tyr Cys Glu Ile Ile 
                165                 170                 175     


Val Thr His Phe Pro Phe Asp Glu Gln Asn Cys Ser Met Lys Leu Gly 
            180                 185                 190         


Thr Trp Thr Tyr Asp Gly Ser Val Val Ala Ile Asn Pro Glu Ser Asp 
        195                 200                 205             


Gln Pro Asp Leu Ser Asn Phe Met Glu Ser Gly Glu Trp Val Ile Lys 
    210                 215                 220                 


Glu Ser Arg Gly Trp Lys His Ser Val Thr Tyr Ser Cys Cys Pro Asp 
225                 230                 235                 240 


Thr Pro Tyr Leu Asp Ile Thr Tyr His Phe Val Met Gln Arg Leu Pro 
                245                 250                 255     


Leu Tyr Phe Ile Val Asn Val Ile Ile Pro Cys Leu Leu Phe Ser Phe 
            260                 265                 270         


Leu Thr Gly Leu Val Phe Tyr Leu Pro Thr Asp Ser Gly Glu Lys Met 
        275                 280                 285             


Thr Leu Ser Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val 
    290                 295                 300                 


Ile Val Glu Leu Ile Pro Ser Thr Ser Ser Ala Val Pro Leu Ile Gly 
305                 310                 315                 320 


Lys Tyr Met Leu Phe Thr Met Val Phe Val Ile Ala Ser Ile Ile Ile 
                325                 330                 335     


Thr Val Ile Val Ile Asn Thr His His Arg Ser Pro Ser Thr His Val 
            340                 345                 350         


Met Pro Asn Trp Val Arg Lys Val Phe Ile Asp Thr Ile Pro Asn Ile 
        355                 360                 365             


Met Phe Phe Ser Thr Met Lys Arg Pro Ser Arg Glu Lys Gln Asp Lys 
    370                 375                 380                 


Lys Ile Phe Thr Glu Asp Ile Asp Ile Ser Asp Ile Ser Gly Lys Pro 
385                 390                 395                 400 


Gly Pro Pro Pro Met Gly Phe His Ser Pro Leu Ile Lys His Pro Glu 
                405                 410                 415     


Val Lys Ser Ala Ile Glu Gly Ile Lys Tyr Ile Ala Glu Thr Met Lys 
            420                 425                 430         


Ser Asp Gln Glu Ser Asn Asn Ala Ala Ala Glu Trp Lys Tyr Val Ala 
        435                 440                 445             


Met Val Met Asp His Ile Leu Leu Gly Val Phe Met Leu Val Cys Ile 
    450                 455                 460                 


Ile Gly Thr Leu Ala Val Phe Ala Gly Arg Leu Ile Glu Leu Asn Gln 
465                 470                 475                 480 


Gln Gly 
        


<210>  3
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Pro Gly Ala Leu Leu Met Leu Leu Gly Ala Leu Gly Ala Pro 
1               5                   10                  15      


Leu Ala Pro Gly Val Arg Gly Ser Glu Ala Glu Gly Arg Leu Arg Glu 
            20                  25                  30          


Lys Leu Phe Ser Gly Tyr Asp Ser Ser Val Arg Pro Ala Arg Glu Val 
        35                  40                  45              


Gly Asp Arg Val Arg Val Ser Val Gly Leu Ile Leu Ala Gln Leu Ile 
    50                  55                  60                  


Ser Leu Asn Glu Lys Asp Glu Glu Met Ser Thr Lys Val Tyr Leu Asp 
65                  70                  75                  80  


Leu Glu Trp Thr Asp Tyr Arg Leu Ser Trp Asp Pro Ala Glu His Asp 
                85                  90                  95      


Gly Ile Asp Ser Leu Arg Ile Thr Ala Glu Ser Val Trp Leu Pro Asp 
            100                 105                 110         


Val Val Leu Leu Asn Asn Asn Asp Gly Asn Phe Asp Val Ala Leu Asp 
        115                 120                 125             


Ile Ser Val Val Val Ser Ser Asp Gly Ser Val Arg Trp Gln Pro Pro 
    130                 135                 140                 


Gly Ile Tyr Arg Ser Ser Cys Ser Ile Gln Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Thr Met Val Phe Ser Ser Tyr Ser Tyr Asp Ser 
                165                 170                 175     


Ser Glu Val Ser Leu Gln Thr Gly Leu Gly Pro Asp Gly Gln Gly His 
            180                 185                 190         


Gln Glu Ile His Ile His Glu Gly Thr Phe Ile Glu Asn Gly Gln Trp 
        195                 200                 205             


Glu Ile Ile His Lys Pro Ser Arg Leu Ile Gln Pro Pro Gly Asp Pro 
    210                 215                 220                 


Arg Gly Gly Arg Glu Gly Gln Arg Gln Glu Val Ile Phe Tyr Leu Ile 
225                 230                 235                 240 


Ile Arg Arg Lys Pro Leu Phe Tyr Leu Val Asn Val Ile Ala Pro Cys 
                245                 250                 255     


Ile Leu Ile Thr Leu Leu Ala Ile Phe Val Phe Tyr Leu Pro Pro Asp 
            260                 265                 270         


Ala Gly Glu Lys Met Gly Leu Ser Ile Phe Ala Leu Leu Thr Leu Thr 
        275                 280                 285             


Val Phe Leu Leu Leu Leu Ala Asp Lys Val Pro Glu Thr Ser Leu Ser 
    290                 295                 300                 


Val Pro Ile Ile Ile Lys Tyr Leu Met Phe Thr Met Val Leu Val Thr 
305                 310                 315                 320 


Phe Ser Val Ile Leu Ser Val Val Val Leu Asn Leu His His Arg Ser 
                325                 330                 335     


Pro His Thr His Gln Met Pro Leu Trp Val Arg Gln Ile Phe Ile His 
            340                 345                 350         


Lys Leu Pro Leu Tyr Leu Arg Leu Lys Arg Pro Lys Pro Glu Arg Asp 
        355                 360                 365             


Leu Met Pro Glu Pro Pro His Cys Ser Ser Pro Gly Ser Gly Trp Gly 
    370                 375                 380                 


Arg Gly Thr Asp Glu Tyr Phe Ile Arg Lys Pro Pro Ser Asp Phe Leu 
385                 390                 395                 400 


Phe Pro Lys Pro Asn Arg Phe Gln Pro Glu Leu Ser Ala Pro Asp Leu 
                405                 410                 415     


Arg Arg Phe Ile Asp Gly Pro Asn Arg Ala Val Ala Leu Leu Pro Glu 
            420                 425                 430         


Leu Arg Glu Val Val Ser Ser Ile Ser Tyr Ile Ala Arg Gln Leu Gln 
        435                 440                 445             


Glu Gln Glu Asp His Asp Ala Leu Lys Glu Asp Trp Gln Phe Val Ala 
    450                 455                 460                 


Met Val Val Asp Arg Leu Phe Leu Trp Thr Phe Ile Ile Phe Thr Ser 
465                 470                 475                 480 


Val Gly Thr Leu Val Ile Phe Leu Asp Ala Thr Tyr His Leu Pro Pro 
                485                 490                 495     


Pro Asp Pro Phe Pro 
            500     


<210>  4
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Thr Lys Val Tyr Leu Asp Leu Glu Trp Thr Asp Tyr Arg Leu 
1               5                   10                  15      


Ser Trp Asp Pro Ala Glu His Asp Gly Ile Asp Ser Leu Arg Ile Thr 
            20                  25                  30          


Ala Glu Ser Val Trp Leu Pro Asp Val Val Leu Leu Asn Asn Asn Asp 
        35                  40                  45              


Gly Asn Phe Asp Val Ala Leu Asp Ile Ser Val Val Val Ser Ser Asp 
    50                  55                  60                  


Gly Ser Val Arg Trp Gln Pro Pro Gly Ile Tyr Arg Ser Ser Cys Ser 
65                  70                  75                  80  


Ile Gln Val Thr Tyr Phe Pro Phe Asp Trp Gln Asn Cys Thr Met Val 
                85                  90                  95      


Phe Ser Ser Tyr Ser Tyr Asp Ser Ser Glu Val Ser Leu Gln Thr Gly 
            100                 105                 110         


Leu Gly Pro Asp Gly Gln Gly His Gln Glu Ile His Ile His Glu Gly 
        115                 120                 125             


Thr Phe Ile Glu Asn Gly Gln Trp Glu Ile Ile His Lys Pro Ser Arg 
    130                 135                 140                 


Leu Ile Gln Pro Pro Gly Asp Pro Arg Gly Gly Arg Glu Gly Gln Arg 
145                 150                 155                 160 


Gln Glu Val Ile Phe Tyr Leu Ile Ile Arg Arg Lys Pro Leu Phe Tyr 
                165                 170                 175     


Leu Val Asn Val Ile Ala Pro Cys Ile Leu Ile Thr Leu Leu Ala Ile 
            180                 185                 190         


Phe Val Phe Tyr Leu Pro Pro Asp Ala Gly Glu Lys Met Gly Leu Ser 
        195                 200                 205             


Ile Phe Ala Leu Leu Thr Leu Thr Val Phe Leu Leu Leu Leu Ala Asp 
    210                 215                 220                 


Lys Val Pro Glu Thr Ser Leu Ser Val Pro Ile Ile Ile Lys Tyr Leu 
225                 230                 235                 240 


Met Phe Thr Met Val Leu Val Thr Phe Ser Val Ile Leu Ser Val Val 
                245                 250                 255     


Val Leu Asn Leu His His Arg Ser Pro His Thr His Gln Met Pro Leu 
            260                 265                 270         


Trp Val Arg Gln Ile Phe Ile His Lys Leu Pro Leu Tyr Leu Arg Leu 
        275                 280                 285             


Lys Arg Pro Lys Pro Glu Arg Asp Leu Met Pro Glu Pro Pro His Cys 
    290                 295                 300                 


Ser Ser Pro Gly Ser Gly Trp Gly Arg Gly Thr Asp Glu Tyr Phe Ile 
305                 310                 315                 320 


Arg Lys Pro Pro Ser Asp Phe Leu Phe Pro Lys Pro Asn Arg Phe Gln 
                325                 330                 335     


Pro Glu Leu Ser Ala Pro Asp Leu Arg Arg Phe Ile Asp Gly Pro Asn 
            340                 345                 350         


Arg Ala Val Ala Leu Leu Pro Glu Leu Arg Glu Val Val Ser Ser Ile 
        355                 360                 365             


Ser Tyr Ile Ala Arg Gln Leu Gln Glu Gln Glu Asp His Asp Ala Leu 
    370                 375                 380                 


Lys Glu Asp Trp Gln Phe Val Ala Met Val Val Asp Arg Leu Phe Leu 
385                 390                 395                 400 


Trp Thr Phe Ile Ile Phe Thr Ser Val Gly Thr Leu Val Ile Phe Leu 
                405                 410                 415     


Asp Ala Thr Tyr His Leu Pro Pro Pro Asp Pro Phe Pro 
            420                 425                 


<210>  5
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  5

Met His Gly Gly Gln Gly Pro Leu Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Cys Leu Gly Ala Gln Gly Arg Asn Gln Glu Glu Arg Leu Leu Ala Asp 
            20                  25                  30          


Leu Met Gln Asn Tyr Asp Pro Asn Leu Arg Pro Ala Glu Arg Asp Ser 
        35                  40                  45              


Asp Val Val Asn Val Ser Leu Lys Leu Thr Leu Thr Asn Leu Ile Ser 
    50                  55                  60                  


Leu Asn Glu Arg Glu Glu Ala Leu Thr Thr Asn Val Trp Ile Glu Met 
65                  70                  75                  80  


Gln Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Arg Asp Tyr Glu Gly 
                85                  90                  95      


Leu Trp Val Leu Arg Val Pro Ser Thr Met Val Trp Arg Pro Asp Ile 
            100                 105                 110         


Val Leu Glu Asn Asn Val Asp Gly Val Phe Glu Val Ala Leu Tyr Cys 
        115                 120                 125             


Asn Val Leu Val Ser Pro Asp Gly Cys Ile Tyr Trp Leu Pro Pro Ala 
    130                 135                 140                 


Ile Phe Arg Ser Ala Cys Ser Ile Ser Val Thr Tyr Phe Pro Phe Asp 
145                 150                 155                 160 


Trp Gln Asn Cys Ser Leu Ile Phe Gln Ser Gln Thr Tyr Ser Thr Asn 
                165                 170                 175     


Glu Ile Asp Leu Gln Leu Ser Gln Glu Asp Gly Gln Thr Ile Glu Trp 
            180                 185                 190         


Ile Phe Ile Asp Pro Glu Ala Phe Thr Glu Asn Gly Glu Trp Ala Ile 
        195                 200                 205             


Gln His Arg Pro Ala Lys Met Leu Leu Asp Pro Ala Ala Pro Ala Gln 
    210                 215                 220                 


Glu Ala Gly His Gln Lys Val Val Phe Tyr Leu Leu Ile Gln Arg Lys 
225                 230                 235                 240 


Pro Leu Phe Tyr Val Ile Asn Ile Ile Ala Pro Cys Val Leu Ile Ser 
                245                 250                 255     


Ser Val Ala Ile Leu Ile His Phe Leu Pro Ala Lys Ala Gly Gly Gln 
            260                 265                 270         


Lys Cys Thr Val Ala Ile Asn Val Leu Leu Ala Gln Thr Val Phe Leu 
        275                 280                 285             


Phe Leu Val Ala Lys Lys Val Pro Glu Thr Ser Gln Ala Val Pro Leu 
    290                 295                 300                 


Ile Ser Lys Tyr Leu Thr Phe Leu Leu Val Val Thr Ile Leu Ile Val 
305                 310                 315                 320 


Val Asn Ala Val Val Val Leu Asn Val Ser Leu Arg Ser Pro His Thr 
                325                 330                 335     


His Ser Met Ala Arg Gly Val Arg Lys Val Phe Leu Arg Leu Leu Pro 
            340                 345                 350         


Gln Leu Leu Arg Met His Val Arg Pro Leu Ala Pro Ala Ala Val Gln 
        355                 360                 365             


Asp Thr Gln Ser Arg Leu Gln Asn Gly Ser Ser Gly Trp Ser Ile Thr 
    370                 375                 380                 


Thr Gly Glu Glu Val Ala Leu Cys Leu Pro Arg Ser Glu Leu Leu Phe 
385                 390                 395                 400 


Gln Gln Trp Gln Arg Gln Gly Leu Val Ala Ala Ala Leu Glu Lys Leu 
                405                 410                 415     


Glu Lys Gly Pro Glu Leu Gly Leu Ser Gln Phe Cys Gly Ser Leu Lys 
            420                 425                 430         


Gln Ala Ala Pro Ala Ile Gln Ala Cys Val Glu Ala Cys Asn Leu Ile 
        435                 440                 445             


Ala Cys Ala Arg His Gln Gln Ser His Phe Asp Asn Gly Asn Glu Glu 
    450                 455                 460                 


Trp Phe Leu Val Gly Arg Val Leu Asp Arg Val Cys Phe Leu Ala Met 
465                 470                 475                 480 


Leu Ser Leu Phe Ile Cys Gly Thr Ala Gly Ile Phe Leu Met Ala His 
                485                 490                 495     


Tyr Asn Arg Val Pro Ala Leu Pro Phe Pro Gly Asp Pro Arg Pro Tyr 
            500                 505                 510         


Leu Pro Ser Pro Asp 
        515         


<210>  6
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  6

Met His Gly Gly Gln Gly Pro Leu Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Cys Leu Gly Ala Gln Gly Arg Asn Gln Glu Glu Arg Leu Leu Ala Asp 
            20                  25                  30          


Leu Met Gln Asn Tyr Asp Pro Asn Leu Arg Pro Ala Glu Arg Asp Ser 
        35                  40                  45              


Asp Val Val Asn Val Ser Leu Lys Leu Thr Leu Thr Asn Leu Ile Ser 
    50                  55                  60                  


Leu Asn Glu Arg Glu Glu Ala Leu Thr Thr Asn Val Trp Ile Glu Met 
65                  70                  75                  80  


Gln Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Arg Asp Tyr Glu Gly 
                85                  90                  95      


Leu Trp Val Leu Arg Val Pro Ser Thr Met Val Trp Arg Pro Asp Ile 
            100                 105                 110         


Val Leu Glu Asn Lys Ser Gln Thr Tyr Ser Thr Asn Glu Ile Asp Leu 
        115                 120                 125             


Gln Leu Ser Gln Glu Asp Gly Gln Thr Ile Glu Trp Ile Phe Ile Asp 
    130                 135                 140                 


Pro Glu Ala Phe Thr Glu Asn Gly Glu Trp Ala Ile Gln His Arg Pro 
145                 150                 155                 160 


Ala Lys Met Leu Leu Asp Pro Ala Ala Pro Ala Gln Glu Ala Gly His 
                165                 170                 175     


Gln Lys Val Val Phe Tyr Leu Leu Ile Gln Arg Lys Pro Leu Phe Tyr 
            180                 185                 190         


Val Ile Asn Ile Ile Ala Pro Cys Val Leu Ile Ser Ser Val Ala Ile 
        195                 200                 205             


Leu Ile His Phe Leu Pro Ala Lys Ala Gly Gly Gln Lys Cys Thr Val 
    210                 215                 220                 


Ala Ile Asn Val Leu Leu Ala Gln Thr Val Phe Leu Phe Leu Val Ala 
225                 230                 235                 240 


Lys Lys Val Pro Glu Thr Ser Gln Ala Val Pro Leu Ile Ser Lys Tyr 
                245                 250                 255     


Leu Thr Phe Leu Leu Val Val Thr Ile Leu Ile Val Val Asn Ala Val 
            260                 265                 270         


Val Val Leu Asn Val Ser Leu Arg Ser Pro His Thr His Ser Met Ala 
        275                 280                 285             


Arg Gly Val Arg Lys Val Phe Leu Arg Leu Leu Pro Gln Leu Leu Arg 
    290                 295                 300                 


Met His Val Arg Pro Leu Ala Pro Ala Ala Val Gln Asp Thr Gln Ser 
305                 310                 315                 320 


Arg Leu Gln Asn Gly Ser Ser Gly Trp Ser Ile Thr Thr Gly Glu Glu 
                325                 330                 335     


Val Ala Leu Cys Leu Pro Arg Ser Glu Leu Leu Phe Gln Gln Trp Gln 
            340                 345                 350         


Arg Gln Gly Leu Val Ala Ala Ala Leu Glu Lys Leu Glu Lys Gly Pro 
        355                 360                 365             


Glu Leu Gly Leu Ser Gln Phe Cys Gly Ser Leu Lys Gln Ala Ala Pro 
    370                 375                 380                 


Ala Ile Gln Ala Cys Val Glu Ala Cys Asn Leu Ile Ala Cys Ala Arg 
385                 390                 395                 400 


His Gln Gln Ser His Phe Asp Asn Gly Asn Glu Glu Trp Phe Leu Val 
                405                 410                 415     


Gly Arg Val Leu Asp Arg Val Cys Phe Leu Ala Met Leu Ser Leu Phe 
            420                 425                 430         


Ile Cys Gly Thr Ala Gly Ile Phe Leu Met Ala His Tyr Asn Arg Val 
        435                 440                 445             


Pro Ala Leu Pro Phe Pro Gly Asp Pro Arg Pro Tyr Leu Pro Ser Pro 
    450                 455                 460                 


Asp 
465 


<210>  7
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Thr Leu Thr Thr Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro Glu 
            100                 105                 110         


Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ser 
        115                 120                 125             


Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro Pro 
    130                 135                 140                 


Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Thr Ala 
                165                 170                 175     


Lys Glu Ile Thr Leu Ser Leu Lys Gln Asp Ala Lys Glu Asn Arg Thr 
            180                 185                 190         


Tyr Pro Val Glu Trp Ile Ile Ile Asp Pro Glu Gly Phe Thr Glu Asn 
        195                 200                 205             


Gly Glu Trp Glu Ile Val His Arg Pro Ala Arg Val Asn Val Asp Pro 
    210                 215                 220                 


Arg Ala Pro Leu Asp Ser Pro Ser Arg Gln Asp Ile Thr Phe Tyr Leu 
225                 230                 235                 240 


Ile Ile Arg Arg Lys Pro Leu Phe Tyr Ile Ile Asn Ile Leu Val Pro 
                245                 250                 255     


Cys Val Leu Ile Ser Phe Met Val Asn Leu Val Phe Tyr Leu Pro Ala 
            260                 265                 270         


Asp Ser Gly Glu Lys Thr Ser Val Ala Ile Ser Val Leu Leu Ala Gln 
        275                 280                 285             


Ser Val Phe Leu Leu Leu Ile Ser Lys Arg Leu Pro Ala Thr Ser Met 
    290                 295                 300                 


Ala Ile Pro Leu Ile Gly Lys Phe Leu Leu Phe Gly Met Val Leu Val 
305                 310                 315                 320 


Thr Met Val Val Val Ile Cys Val Ile Val Leu Asn Ile His Phe Arg 
                325                 330                 335     


Thr Pro Ser Thr His Val Leu Ser Glu Gly Val Lys Lys Leu Phe Leu 
            340                 345                 350         


Glu Thr Leu Pro Glu Leu Leu His Met Ser Arg Pro Ala Glu Asp Gly 
        355                 360                 365             


Pro Ser Pro Gly Ala Leu Val Arg Arg Ser Ser Ser Leu Gly Tyr Ile 
    370                 375                 380                 


Ser Lys Ala Glu Glu Tyr Phe Leu Leu Lys Ser Arg Ser Asp Leu Met 
385                 390                 395                 400 


Phe Glu Lys Gln Ser Glu Arg His Gly Leu Ala Arg Arg Leu Thr Thr 
                405                 410                 415     


Ala Arg Arg Pro Pro Ala Ser Ser Glu Gln Ala Gln Gln Glu Leu Phe 
            420                 425                 430         


Asn Glu Leu Lys Pro Ala Val Asp Gly Ala Asn Phe Ile Val Asn His 
        435                 440                 445             


Met Arg Asp Gln Asn Asn Tyr Asn Glu Glu Lys Asp Ser Trp Asn Arg 
    450                 455                 460                 


Val Ala Arg Thr Val Asp Arg Leu Cys Leu Phe Val Val Thr Pro Val 
465                 470                 475                 480 


Met Val Val Gly Thr Ala Trp Ile Phe Leu Gln Gly Val Tyr Asn Gln 
                485                 490                 495     


Pro Pro Pro Gln Pro Phe Pro Gly Asp Pro Tyr Ser Tyr Asn Val Gln 
            500                 505                 510         


Asp Lys Arg Phe Ile 
        515         


<210>  8
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe 
65                  70                  75                  80  


Gly Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro 
                85                  90                  95      


Glu Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr 
            100                 105                 110         


Ser Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro 
        115                 120                 125             


Pro Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro 
    130                 135                 140                 


Phe Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Thr 
145                 150                 155                 160 


Ala Lys Glu Ile Thr Leu Ser Leu Lys Gln Asp Ala Lys Glu Asn Arg 
                165                 170                 175     


Thr Tyr Pro Val Glu Trp Ile Ile Ile Asp Pro Glu Gly Phe Thr Glu 
            180                 185                 190         


Asn Gly Glu Trp Glu Ile Val His Arg Pro Ala Arg Val Asn Val Asp 
        195                 200                 205             


Pro Arg Ala Pro Leu Asp Ser Pro Ser Arg Gln Asp Ile Thr Phe Tyr 
    210                 215                 220                 


Leu Ile Ile Arg Arg Lys Pro Leu Phe Tyr Ile Ile Asn Ile Leu Val 
225                 230                 235                 240 


Pro Cys Val Leu Ile Ser Phe Met Val Asn Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Ala Asp Ser Gly Glu Lys Thr Ser Val Ala Ile Ser Val Leu Leu Ala 
            260                 265                 270         


Gln Ser Val Phe Leu Leu Leu Ile Ser Lys Arg Leu Pro Ala Thr Ser 
        275                 280                 285             


Met Ala Ile Pro Leu Ile Gly Lys Phe Leu Leu Phe Gly Met Val Leu 
    290                 295                 300                 


Val Thr Met Val Val Val Ile Cys Val Ile Val Leu Asn Ile His Phe 
305                 310                 315                 320 


Arg Thr Pro Ser Thr His Val Leu Ser Glu Gly Val Lys Lys Leu Phe 
                325                 330                 335     


Leu Glu Thr Leu Pro Glu Leu Leu His Met Ser Arg Pro Ala Glu Asp 
            340                 345                 350         


Gly Pro Ser Pro Gly Ala Leu Val Arg Arg Ser Ser Ser Leu Gly Tyr 
        355                 360                 365             


Ile Ser Lys Ala Glu Glu Tyr Phe Leu Leu Lys Ser Arg Ser Asp Leu 
    370                 375                 380                 


Met Phe Glu Lys Gln Ser Glu Arg His Gly Leu Ala Arg Arg Leu Thr 
385                 390                 395                 400 


Thr Ala Arg Arg Pro Pro Ala Ser Ser Glu Gln Ala Gln Gln Glu Leu 
                405                 410                 415     


Phe Asn Glu Leu Lys Pro Ala Val Asp Gly Ala Asn Phe Ile Val Asn 
            420                 425                 430         


His Met Arg Asp Gln Asn Asn Tyr Asn Glu Glu Lys Asp Ser Trp Asn 
        435                 440                 445             


Arg Val Ala Arg Thr Val Asp Arg Leu Cys Leu Phe Val Val Thr Pro 
    450                 455                 460                 


Val Met Val Val Gly Thr Ala Trp Ile Phe Leu Gln Gly Val Tyr Asn 
465                 470                 475                 480 


Gln Pro Pro Pro Gln Pro Phe Pro Gly Asp Pro Tyr Ser Tyr Asn Val 
                485                 490                 495     


Gln Asp Lys Arg Phe Ile 
            500         


<210>  9
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Arg Ala Pro Leu Gly Val Leu Leu Leu Leu Gly Leu Leu Gly 
1               5                   10                  15      


Arg Gly Val Gly Lys Asn Glu Glu Leu Arg Leu Tyr His His Leu Phe 
            20                  25                  30          


Asn Asn Tyr Asp Pro Gly Ser Arg Pro Val Arg Glu Pro Glu Asp Thr 
        35                  40                  45              


Val Thr Ile Ser Leu Lys Val Thr Leu Thr Asn Leu Ile Ser Leu Asn 
    50                  55                  60                  


Glu Lys Glu Glu Thr Leu Thr Thr Ser Val Trp Ile Gly Ile Asp Trp 
65                  70                  75                  80  


Gln Asp Tyr Arg Leu Asn Tyr Ser Lys Asp Asp Phe Gly Gly Ile Glu 
                85                  90                  95      


Thr Leu Arg Val Pro Ser Glu Leu Val Trp Leu Pro Glu Ile Val Leu 
            100                 105                 110         


Glu Asn Asn Ile Asp Gly Gln Phe Gly Val Ala Tyr Asp Ala Asn Val 
        115                 120                 125             


Leu Val Tyr Glu Gly Gly Ser Val Thr Trp Leu Pro Pro Ala Ile Tyr 
    130                 135                 140                 


Arg Ser Val Cys Ala Val Glu Val Thr Tyr Phe Pro Phe Asp Trp Gln 
145                 150                 155                 160 


Asn Cys Ser Leu Ile Phe Arg Ser Gln Thr Tyr Asn Ala Glu Glu Val 
                165                 170                 175     


Glu Phe Thr Phe Ala Val Asp Asn Asp Gly Lys Thr Ile Asn Lys Ile 
            180                 185                 190         


Asp Ile Asp Thr Glu Ala Tyr Thr Glu Asn Gly Glu Trp Ala Ile Asp 
        195                 200                 205             


Phe Cys Pro Gly Val Ile Arg Arg His His Gly Gly Ala Thr Asp Gly 
    210                 215                 220                 


Pro Gly Glu Thr Asp Val Ile Tyr Ser Leu Ile Ile Arg Arg Lys Pro 
225                 230                 235                 240 


Leu Phe Tyr Val Ile Asn Ile Ile Val Pro Cys Val Leu Ile Ser Gly 
                245                 250                 255     


Leu Val Leu Leu Ala Tyr Phe Leu Pro Ala Gln Ala Gly Gly Gln Lys 
            260                 265                 270         


Cys Thr Val Ser Ile Asn Val Leu Leu Ala Gln Thr Val Phe Leu Phe 
        275                 280                 285             


Leu Ile Ala Gln Lys Ile Pro Glu Thr Ser Leu Ser Val Pro Leu Leu 
    290                 295                 300                 


Gly Arg Phe Leu Ile Phe Val Met Val Val Ala Thr Leu Ile Val Met 
305                 310                 315                 320 


Asn Cys Val Ile Val Leu Asn Val Ser Gln Arg Thr Pro Thr Thr His 
                325                 330                 335     


Ala Met Ser Pro Arg Leu Arg His Val Leu Leu Glu Leu Leu Pro Arg 
            340                 345                 350         


Leu Leu Gly Ser Pro Pro Pro Pro Glu Ala Pro Arg Ala Ala Ser Pro 
        355                 360                 365             


Pro Arg Arg Ala Ser Ser Val Gly Leu Leu Leu Arg Ala Glu Glu Leu 
    370                 375                 380                 


Ile Leu Lys Lys Pro Arg Ser Glu Leu Val Phe Glu Gly Gln Arg His 
385                 390                 395                 400 


Arg Gln Gly Thr Trp Thr Ala Ala Phe Cys Gln Ser Leu Gly Ala Ala 
                405                 410                 415     


Ala Pro Glu Val Arg Cys Cys Val Asp Ala Val Asn Phe Val Ala Glu 
            420                 425                 430         


Ser Thr Arg Asp Gln Glu Ala Thr Gly Glu Glu Val Ser Asp Trp Val 
        435                 440                 445             


Arg Met Gly Asn Ala Leu Asp Asn Ile Cys Phe Trp Ala Ala Leu Val 
    450                 455                 460                 


Leu Phe Ser Val Gly Ser Ser Leu Ile Phe Leu Gly Ala Tyr Phe Asn 
465                 470                 475                 480 


Arg Val Pro Asp Leu Pro Tyr Ala Pro Cys Ile Gln Pro 
                485                 490             


<210>  10
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro 
225                 230     


<210>  11
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala 
225                 230                 235                 240 


Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser Ser Glu 
                245                 250                 255     


Ala Glu Gly Arg Leu Arg Glu Lys Leu Phe Ser Gly Tyr Asp Ser Ser 
            260                 265                 270         


Val Arg Pro Ala Arg Glu Val Gly Asp Arg Val Arg Val Ser Val Gly 
        275                 280                 285             


Leu Ile Leu Ala Gln Leu Ile Ser Leu Asn Glu Lys Asp Glu Glu Met 
    290                 295                 300                 


Ser Thr Lys Val Tyr Leu Asp Leu Glu Trp Thr Asp Tyr Arg Leu Ser 
305                 310                 315                 320 


Trp Asp Pro Ala Glu His Asp Gly Ile Asp Ser Leu Arg Ile Thr Ala 
                325                 330                 335     


Glu Ser Val Trp Leu Pro Asp Val Val Leu Leu Asn Asn Asn Asp Gly 
            340                 345                 350         


Asn Phe Asp Val Ala Leu Asp Ile Ser Val Val Val Ser Ser Asp Gly 
        355                 360                 365             


Ser Val Arg Trp Gln Pro Pro Gly Ile Tyr Arg Ser Ser Cys Ser Ile 
    370                 375                 380                 


Gln Val Thr Tyr Phe Pro Phe Asp Trp Gln Asn Cys Thr Met Val Phe 
385                 390                 395                 400 


Ser Ser Tyr Ser Tyr Asp Ser Ser Glu Val Ser Leu Gln Thr Gly Leu 
                405                 410                 415     


Gly Pro Asp Gly Gln Gly His Gln Glu Ile His Ile His Glu Gly Thr 
            420                 425                 430         


Phe Ile Glu Asn Gly Gln Trp Glu Asn Ile His Lys Pro Ser Arg Leu 
        435                 440                 445             


Ile Gln Pro Pro Gly Asp Pro Arg Gly Gly Arg Glu Gly Gln Arg Gln 
    450                 455                 460                 


Glu Val Ile Phe Tyr Leu Ile Ile Arg Arg Lys 
465                 470                 475 


<210>  12
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  12

Met His Gly Gly Gln Gly Pro Leu Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Cys Leu Gly Ala Gln Gly Arg Asn Gln Glu Glu Arg Leu Leu Ala Asp 
            20                  25                  30          


Leu Met Gln Asn Tyr Asp Pro Asn Leu Arg Pro Ala Glu Arg Asp Ser 
        35                  40                  45              


Asp Val Val Asn Val Ser Leu Lys Leu Thr Leu Thr Asn Leu Ile Ser 
    50                  55                  60                  


Leu Asn Glu Arg Glu Glu Ala Leu Thr Thr Asn Val Trp Ile Glu Met 
65                  70                  75                  80  


Gln Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Arg Asp Tyr Glu Gly 
                85                  90                  95      


Leu Trp Val Leu Arg Val Pro Ser Thr Met Val Trp Arg Pro Asp Ile 
            100                 105                 110         


Val Leu Glu Asn Asn Val Asp Gly Val Phe Glu Val Ala Leu Tyr Cys 
        115                 120                 125             


Asn Val Leu Val Ser Pro Asp Gly Cys Ile Tyr Trp Leu Pro Pro Ala 
    130                 135                 140                 


Ile Phe Arg Ser Ala Cys Ser Ile Ser Val Thr Tyr Phe Pro Phe Asp 
145                 150                 155                 160 


Trp Gln Asn Cys Ser Leu Ile Phe Gln Ser Gln Thr Tyr Ser Thr Asn 
                165                 170                 175     


Glu Ile Asp Leu Gln Leu Ser Gln Glu Asp Gly Gln Thr Ile Glu Trp 
            180                 185                 190         


Ile Phe Ile Asp Pro Glu Ala Phe Thr Glu Asn Gly Glu Trp Ala Ile 
        195                 200                 205             


Gln His Arg Pro Ala Lys Met Leu Leu Asp Pro Ala Ala Pro Ala Gln 
    210                 215                 220                 


Glu Ala Gly His Gln Lys Val Val Phe Tyr Leu Leu Ile Gln Arg Lys 
225                 230                 235                 240 


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  13

Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly 
1               5                   10                  


<210>  14
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  14

Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala 
1               5                   10                  15      


Gly Ser Ala Gly Ser Ala Gly Ser 
            20                  


<210>  15
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane

<400>  15

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  16
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-stimulatory

<400>  16

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Activation

<400>  17

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  18
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR

<400>  18

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro Ala Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Ser Gly Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                245                 250                 255     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
            260                 265                 270         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        275                 280                 285             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    290                 295                 300                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
305                 310                 315                 320 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                325                 330                 335     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            340                 345                 350         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        355                 360                 365             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    370                 375                 380                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
385                 390                 395                 400 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                405                 410                 415     


Met Gln Ala Leu Pro Pro Arg 
            420             


<210>  19
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR

<400>  19

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala 
225                 230                 235                 240 


Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser Ser Glu 
                245                 250                 255     


Ala Glu Gly Arg Leu Arg Glu Lys Leu Phe Ser Gly Tyr Asp Ser Ser 
            260                 265                 270         


Val Arg Pro Ala Arg Glu Val Gly Asp Arg Val Arg Val Ser Val Gly 
        275                 280                 285             


Leu Ile Leu Ala Gln Leu Ile Ser Leu Asn Glu Lys Asp Glu Glu Met 
    290                 295                 300                 


Ser Thr Lys Val Tyr Leu Asp Leu Glu Trp Thr Asp Tyr Arg Leu Ser 
305                 310                 315                 320 


Trp Asp Pro Ala Glu His Asp Gly Ile Asp Ser Leu Arg Ile Thr Ala 
                325                 330                 335     


Glu Ser Val Trp Leu Pro Asp Val Val Leu Leu Asn Asn Asn Asp Gly 
            340                 345                 350         


Asn Phe Asp Val Ala Leu Asp Ile Ser Val Val Val Ser Ser Asp Gly 
        355                 360                 365             


Ser Val Arg Trp Gln Pro Pro Gly Ile Tyr Arg Ser Ser Cys Ser Ile 
    370                 375                 380                 


Gln Val Thr Tyr Phe Pro Phe Asp Trp Gln Asn Cys Thr Met Val Phe 
385                 390                 395                 400 


Ser Ser Tyr Ser Tyr Asp Ser Ser Glu Val Ser Leu Gln Thr Gly Leu 
                405                 410                 415     


Gly Pro Asp Gly Gln Gly His Gln Glu Ile His Ile His Glu Gly Thr 
            420                 425                 430         


Phe Ile Glu Asn Gly Gln Trp Glu Asn Ile His Lys Pro Ser Arg Leu 
        435                 440                 445             


Ile Gln Pro Pro Gly Asp Pro Arg Gly Gly Arg Glu Gly Gln Arg Gln 
    450                 455                 460                 


Glu Val Ile Phe Tyr Leu Ile Ile Arg Arg Lys Ala Ser Gly Gly Gly 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Ser Gly Ile Tyr Ile Trp Ala Pro Leu 
                485                 490                 495     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            500                 505                 510         


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        515                 520                 525             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    530                 535                 540                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
545                 550                 555                 560 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                565                 570                 575     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            580                 585                 590         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        595                 600                 605             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    610                 615                 620                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
625                 630                 635                 640 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                645                 650                 655     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665         


<210>  20
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR

<400>  20

Met His Gly Gly Gln Gly Pro Leu Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Cys Leu Gly Ala Gln Gly Arg Asn Gln Glu Glu Arg Leu Leu Ala Asp 
            20                  25                  30          


Leu Met Gln Asn Tyr Asp Pro Asn Leu Arg Pro Ala Glu Arg Asp Ser 
        35                  40                  45              


Asp Val Val Asn Val Ser Leu Lys Leu Thr Leu Thr Asn Leu Ile Ser 
    50                  55                  60                  


Leu Asn Glu Arg Glu Glu Ala Leu Thr Thr Asn Val Trp Ile Glu Met 
65                  70                  75                  80  


Gln Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Arg Asp Tyr Glu Gly 
                85                  90                  95      


Leu Trp Val Leu Arg Val Pro Ser Thr Met Val Trp Arg Pro Asp Ile 
            100                 105                 110         


Val Leu Glu Asn Asn Val Asp Gly Val Phe Glu Val Ala Leu Tyr Cys 
        115                 120                 125             


Asn Val Leu Val Ser Pro Asp Gly Cys Ile Tyr Trp Leu Pro Pro Ala 
    130                 135                 140                 


Ile Phe Arg Ser Ala Cys Ser Ile Ser Val Thr Tyr Phe Pro Phe Asp 
145                 150                 155                 160 


Trp Gln Asn Cys Ser Leu Ile Phe Gln Ser Gln Thr Tyr Ser Thr Asn 
                165                 170                 175     


Glu Ile Asp Leu Gln Leu Ser Gln Glu Asp Gly Gln Thr Ile Glu Trp 
            180                 185                 190         


Ile Phe Ile Asp Pro Glu Ala Phe Thr Glu Asn Gly Glu Trp Ala Ile 
        195                 200                 205             


Gln His Arg Pro Ala Lys Met Leu Leu Asp Pro Ala Ala Pro Ala Gln 
    210                 215                 220                 


Glu Ala Gly His Gln Lys Val Val Phe Tyr Leu Leu Ile Gln Arg Lys 
225                 230                 235                 240 


Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Ile Tyr 
                245                 250                 255     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            260                 265                 270         


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        275                 280                 285             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    290                 295                 300                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
305                 310                 315                 320 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                325                 330                 335     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            340                 345                 350         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        355                 360                 365             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    370                 375                 380                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
385                 390                 395                 400 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                405                 410                 415     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430         


<210>  21
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Thr Pro Gly Ala Leu Leu Met Leu Leu Gly Ala Leu Gly Pro Pro 
1               5                   10                  15      


Leu Ala Pro Gly Val Arg Gly Ser Glu Ala Glu Gly Arg Leu Arg Glu 
            20                  25                  30          


Lys Leu Phe Ser Gly Tyr Asp Ser Ser Val Arg Pro Ala Arg Glu Val 
        35                  40                  45              


Gly Asp Arg Val Arg Val Ser Val Gly Leu Ile Leu Ala Gln Leu Ile 
    50                  55                  60                  


Ser Leu Asn Glu Lys Asp Glu Glu Met Ser Thr Lys Val Tyr Leu Asp 
65                  70                  75                  80  


Leu Glu Trp Thr Asp Tyr Arg Leu Ser Trp Asp Pro Ala Glu His Asp 
                85                  90                  95      


Gly Ile Asp Ser Leu Arg Ile Thr Ala Glu Ser Val Trp Leu Pro Asp 
            100                 105                 110         


Val Val Leu Leu Asn Asn Asn Asp Gly Asn Phe Asp Val Ala Leu Asp 
        115                 120                 125             


Ile Ser Val Val Val Ser Ser Asp Gly Ser Val Arg Trp Gln Pro Pro 
    130                 135                 140                 


Gly Ile Tyr Arg Ser Ser Cys Ser Ile Gln Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Thr Met Val Phe Ser Ser Tyr Ser Tyr Asp Ser 
                165                 170                 175     


Ser Glu Val Ser Leu Gln Thr Gly Leu Gly Pro Asp Gly Gln Gly His 
            180                 185                 190         


Gln Glu Ile His Ile His Glu Gly Thr Phe Ile Glu Asn Gly Gln Trp 
        195                 200                 205             


Glu Asn Ile His Lys Pro Ser Arg Leu Ile Gln Pro Pro Gly Asp Pro 
    210                 215                 220                 


Arg Gly Gly Arg Glu Gly Gln Arg Gln Glu Val Ile Phe Tyr Leu Ile 
225                 230                 235                 240 


Ile Arg Arg Lys 
                


<210>  22
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR

<400>  22

Met Thr Pro Gly Ala Leu Leu Met Leu Leu Gly Ala Leu Gly Pro Pro 
1               5                   10                  15      


Leu Ala Pro Gly Val Arg Gly Ser Glu Ala Glu Gly Arg Leu Arg Glu 
            20                  25                  30          


Lys Leu Phe Ser Gly Tyr Asp Ser Ser Val Arg Pro Ala Arg Glu Val 
        35                  40                  45              


Gly Asp Arg Val Arg Val Ser Val Gly Leu Ile Leu Ala Gln Leu Ile 
    50                  55                  60                  


Ser Leu Asn Glu Lys Asp Glu Glu Met Ser Thr Lys Val Tyr Leu Asp 
65                  70                  75                  80  


Leu Glu Trp Thr Asp Tyr Arg Leu Ser Trp Asp Pro Ala Glu His Asp 
                85                  90                  95      


Gly Ile Asp Ser Leu Arg Ile Thr Ala Glu Ser Val Trp Leu Pro Asp 
            100                 105                 110         


Val Val Leu Leu Asn Asn Asn Asp Gly Asn Phe Asp Val Ala Leu Asp 
        115                 120                 125             


Ile Ser Val Val Val Ser Ser Asp Gly Ser Val Arg Trp Gln Pro Pro 
    130                 135                 140                 


Gly Ile Tyr Arg Ser Ser Cys Ser Ile Gln Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Thr Met Val Phe Ser Ser Tyr Ser Tyr Asp Ser 
                165                 170                 175     


Ser Glu Val Ser Leu Gln Thr Gly Leu Gly Pro Asp Gly Gln Gly His 
            180                 185                 190         


Gln Glu Ile His Ile His Glu Gly Thr Phe Ile Glu Asn Gly Gln Trp 
        195                 200                 205             


Glu Asn Ile His Lys Pro Ser Arg Leu Ile Gln Pro Pro Gly Asp Pro 
    210                 215                 220                 


Arg Gly Gly Arg Glu Gly Gln Arg Gln Glu Val Ile Phe Tyr Leu Ile 
225                 230                 235                 240 


Ile Arg Arg Lys Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Ser Gly Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            260                 265                 270         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


