                         SEQUENCE LISTING

<110>  Universit Libre de Bruxelles
       Universit de Mons
 
<120>  MODULATION OF PRDM12 FOR USE IN TREATMENT OF PAIN CONDITIONS

<130>  ULB-114-PCT

<150>  20215921.6
<151>  2020-12-21

<150>  21192681.1
<151>  2021-08-23

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  367
<212>  PRT
<213>  Prdm12 protein

<400>  1

Met Met Gly Ser Val Leu Pro Ala Glu Ala Leu Val Leu Lys Thr Gly 
1               5                   10                  15      


Leu Lys Ala Pro Gly Leu Ala Leu Ala Glu Val Ile Thr Ser Asp Ile 
            20                  25                  30          


Leu His Ser Phe Leu Tyr Gly Arg Trp Arg Asn Val Leu Gly Glu Gln 
        35                  40                  45              


Leu Phe Glu Asp Lys Ser His His Ala Ser Pro Lys Thr Ala Phe Thr 
    50                  55                  60                  


Ala Glu Val Leu Ala Gln Ser Phe Ser Gly Glu Val Gln Lys Leu Ser 
65                  70                  75                  80  


Ser Leu Val Leu Pro Ala Glu Val Ile Ile Ala Gln Ser Ser Ile Pro 
                85                  90                  95      


Gly Glu Gly Leu Gly Ile Phe Ser Lys Thr Trp Ile Lys Ala Gly Thr 
            100                 105                 110         


Glu Met Gly Pro Phe Thr Gly Arg Val Ile Ala Pro Glu His Val Asp 
        115                 120                 125             


Ile Cys Lys Asn Asn Asn Leu Met Trp Glu Val Phe Asn Glu Asp Gly 
    130                 135                 140                 


Thr Val Arg Tyr Phe Ile Asp Ala Ser Gln Glu Asp His Arg Ser Trp 
145                 150                 155                 160 


Met Thr Tyr Ile Lys Cys Ala Arg Asn Glu Gln Glu Gln Asn Leu Glu 
                165                 170                 175     


Val Val Gln Ile Gly Thr Ser Ile Phe Tyr Lys Ala Ile Glu Met Ile 
            180                 185                 190         


Pro Pro Asp Gln Glu Leu Leu Val Trp Tyr Gly Asn Ser His Asn Thr 
        195                 200                 205             


Phe Leu Gly Ile Pro Gly Val Pro Gly Leu Glu Glu Asp Gln Lys Lys 
    210                 215                 220                 


Asn Lys His Glu Asp Phe His Pro Ala Asp Ser Ala Ala Gly Pro Ala 
225                 230                 235                 240 


Gly Arg Met Arg Cys Val Ile Cys His Arg Gly Phe Asn Ser Arg Ser 
                245                 250                 255     


Asn Leu Arg Ser His Met Arg Ile His Thr Leu Asp Lys Pro Phe Val 
            260                 265                 270         


Cys Arg Phe Cys Asn Arg Arg Phe Ser Gln Ser Ser Thr Leu Arg Asn 
        275                 280                 285             


His Val Arg Leu His Thr Gly Glu Arg Pro Tyr Lys Cys Gln Val Cys 
    290                 295                 300                 


Gln Ser Ala Tyr Ser Gln Leu Ala Gly Leu Arg Ala His Gln Lys Ser 
305                 310                 315                 320 


Ala Arg His Arg Pro Pro Ser Thr Ala Leu Gln Ala His Ser Pro Ala 
                325                 330                 335     


Leu Pro Ala Pro His Ala His Ala Pro Ala Leu Ala Ala Ala Ala Ala 
            340                 345                 350         


Ala Ala Ala Ala Ala Ala Ala His His Leu Pro Ala Met Val Leu 
        355                 360                 365         


<210>  2
<211>  2478
<212>  DNA
<213>  Prdm12 mRNA

<400>  2
cccgcccacc tcccccgtcg gcccggccgt cccccggcgc cggggagctc cgggccgccc       60

atgatgggct ccgtgctccc ggctgaggcc ctggtgctca agaccgggct gaaggcgccg      120

ggactggcgc tggccgaggt tatcacctcc gacatcctgc acagcttcct gtacggccgc      180

tggcgcaacg tgctcgggga gcagctcttc gaggacaaga gccaccacgc cagccccaag      240

acagccttca ccgccgaggt gctggcgcag tccttctccg gcgaagtgca gaagctgtcc      300

agcctggtgc tgcctgcgga ggtgatcatc gctcagagct ccatccctgg cgagggcctc      360

ggcatcttct ccaagacgtg gatcaaggcg ggaaccgaga tgggcccctt caccggccgc      420

gtgatcgccc cggagcacgt ggacatctgc aagaacaaca acctcatgtg ggaggtgttc      480

aatgaggatg gcacggtgcg ctacttcatc gatgccagcc aggaggacca ccggagctgg      540

atgacctaca tcaagtgtgc acgtaacgaa caggagcaga acctggaggt ggtccagatc      600

ggcaccagca tcttctacaa ggccattgag atgatcccac ctgaccagga actgctggtg      660

tggtacggaa actcacacaa caccttcctg gggatcccag gtgtgcccgg gctagaggag      720

gaccagaaaa agaacaagca tgaggacttc cacccggcgg actcggcggc tggccccgcg      780

ggccgcatgc gatgcgtcat ctgccaccgc ggcttcaact cgcgcagcaa cctgcgctcg      840

cacatgcgca tccacacgct ggacaagccc ttcgtgtgcc gcttctgcaa ccgccgcttc      900

agccagtcgt ccacgctgcg caaccacgtg cgcctgcaca cgggcgagcg cccctacaag      960

tgccaggtgt gccagagcgc ctactcgcag ctggccggcc tgcgcgccca ccagaagagc     1020

gcgcggcacc ggccgcccag caccgcgctg caggcacact cgcccgcgct gcccgccccg     1080

cacgcgcacg cgcccgcgct cgccgccgcc gccgccgccg ccgccgccgc cgccgcgcac     1140

cacctgccgg ccatggtgct gtgagcgcgc ccgcgccccc gccgggcccc gcgcgctcct     1200

gggtccccgg caccccggcc ccgcagcgcg actcgccctc cagccccaac ccccggcccg     1260

gcgccgccgc ggagccccgc gcgctggggt tgcgccccgg aggcggatct caggcacccc     1320

cgccttggcc cgtgtcgcag atgaggacac tgagggcggc gtccctcacc caggccacgc     1380

agctggtgcg gctgttcggc cgcctcctct gggagggggt ccccctgcct ggcctcgccc     1440

ccgagtctcc ctgctgctgt agagccgggc gcccaggccg gcatccccct cgtgggtggc     1500

aggagagcgg acttagagcc cccgagggcc cctcagcaga ggaaggggag tcccctcctc     1560

cgccaccgag agtcctgtgc ttcggaatga agggagggcg acctccttgt ccgggtgtgg     1620

tcgggcgcgg gggttgtggg ggcgccatct cctcttccgg cccctgggac tggtgtcctg     1680

aagtgtcggg agtccttacg caaccttgac atgtgcgggc tactggggtc catcggcagc     1740

gggaagagac ccggagagat gcatcttctg ggcccttctc tcctttaggc cagcttaccc     1800

ccaaacctgg ctcctgggga cggatgagga aggagctctt tgcagtgcac caggcacgtt     1860

gagagtggag gcacaatgga aatcctctgt gggaccccga gcaagaccct gcacctcttt     1920

gggcctcagt ttccccatct gtaaaatgaa ggagttggac caatgccccc tccccttcag     1980

ctgtgacatc gtgcctggga aggcgaaata tacccccagc cccttccaac acacacactc     2040

cagcgagagg agggcaagac tggaaccgct gcccgagagg ttaaggtggc ttctgtggcc     2100

acgaagcgct tccgagctgt gcccagtccc gggaattccg cccagtctgc ccacacttcc     2160

ctcggtccct gcccgtttcc tcaaattcgg gccgtgcgcg ccctctggtg tcgcctctca     2220

cactttgcag tcatttacca ggattcccgt agggcgtttt gtaaaataaa ctataatatt     2280

aatgaaaagt ataaaatgta tagagttttc aagaaactgc gttctacttc cagaagatgg     2340

tcactttaac cttgtaaata tttatctaaa atgatattta caaaactgta atatattatt     2400

atttgattgt atatgtacaa ctgtaaatac atttgtacct ctcttgtatt ctaaaataaa     2460

aattacttgg aacattta                                                   2478


<210>  3
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  3
ctcaggagag gtgcagaagc                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  4
atatccacat gctctggggc                                                   20


<210>  5
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  5
tgagagctgg atcaaatggc t                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  6
gctttgtaca gcgcatagga a                                                 21


<210>  7
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  7
gaggtggagt tcgccaagca ag                                                22


<210>  8
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  8
ctgaagccag atgtgttcta ccc                                               23


<210>  9
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  9
tccctggaat gtttccttca gtt                                               23


<210>  10
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  10
agatagagag cgctcaacac tg                                                22


<210>  11
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  11
catgcttgga gctgagtcct ca                                                22


<210>  12
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  12
tagcagacgg tgagcgtgag aa                                                22


<210>  13
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  13
tctgcatcgt cctggcttt                                                    19


<210>  14
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  14
cttggccagt tcctgtttcc                                                   20


<210>  15
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  15
gtgacggctt acgaactgct ga                                                22


<210>  16
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  16
tctcctgtga ccaggcagaa gg                                                22


<210>  17
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  17
gagacacttc gagttccagc ag                                                22


<210>  18
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  18
ggtccaggtt atcacaccgt ca                                                22


<210>  19
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  19
gaatgacaaa ggggagtgga                                                   20


<210>  20
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  20
aaggtcattg tcgagcca                                                     18


<210>  21
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  21
ccatcagtgt tgagcgctct                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  22
gtcctgcatg gctctctgaa                                                   20


<210>  23
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  23
gatatttggg gacttggcct g                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  24
gctttgaaat tctccccagc a                                                 21


<210>  25
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  25
gctgatcgag tccaggagac                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  26
ccaaacatcc acaaccttca                                                   20


<210>  27
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  27
gacagattat ctgcaatctc tctaag                                            26


<210>  28
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  28
gttcctgatg ttcctggcat ctgtc                                             25


<210>  29
<211>  1210
<212>  PRT
<213>  canonical human G9a protein

<400>  29

Met Ala Ala Ala Ala Gly Ala Ala Ala Ala Ala Ala Ala Glu Gly Glu 
1               5                   10                  15      


Ala Pro Ala Glu Met Gly Ala Leu Leu Leu Glu Lys Glu Thr Arg Gly 
            20                  25                  30          


Ala Thr Glu Arg Val His Gly Ser Leu Gly Asp Thr Pro Arg Ser Glu 
        35                  40                  45              


Glu Thr Leu Pro Lys Ala Thr Pro Asp Ser Leu Glu Pro Ala Gly Pro 
    50                  55                  60                  


Ser Ser Pro Ala Ser Val Thr Val Thr Val Gly Asp Glu Gly Ala Asp 
65                  70                  75                  80  


Thr Pro Val Gly Ala Thr Pro Leu Ile Gly Asp Glu Ser Glu Asn Leu 
                85                  90                  95      


Glu Gly Asp Gly Asp Leu Arg Gly Gly Arg Ile Leu Leu Gly His Ala 
            100                 105                 110         


Thr Lys Ser Phe Pro Ser Ser Pro Ser Lys Gly Gly Ser Cys Pro Ser 
        115                 120                 125             


Arg Ala Lys Met Ser Met Thr Gly Ala Gly Lys Ser Pro Pro Ser Val 
    130                 135                 140                 


Gln Ser Leu Ala Met Arg Leu Leu Ser Met Pro Gly Ala Gln Gly Ala 
145                 150                 155                 160 


Ala Ala Ala Gly Ser Glu Pro Pro Pro Ala Thr Thr Ser Pro Glu Gly 
                165                 170                 175     


Gln Pro Lys Val His Arg Ala Arg Lys Thr Met Ser Lys Pro Gly Asn 
            180                 185                 190         


Gly Gln Pro Pro Val Pro Glu Lys Arg Pro Pro Glu Ile Gln His Phe 
        195                 200                 205             


Arg Met Ser Asp Asp Val His Ser Leu Gly Lys Val Thr Ser Asp Leu 
    210                 215                 220                 


Ala Lys Arg Arg Lys Leu Asn Ser Gly Gly Gly Leu Ser Glu Glu Leu 
225                 230                 235                 240 


Gly Ser Ala Arg Arg Ser Gly Glu Val Thr Leu Thr Lys Gly Asp Pro 
                245                 250                 255     


Gly Ser Leu Glu Glu Trp Glu Thr Val Val Gly Asp Asp Phe Ser Leu 
            260                 265                 270         


Tyr Tyr Asp Ser Tyr Ser Val Asp Glu Arg Val Asp Ser Asp Ser Lys 
        275                 280                 285             


Ser Glu Val Glu Ala Leu Thr Glu Gln Leu Ser Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Glu Glu Asp Glu Glu Ser Gly Asn Gln Ser Asp Arg Ser Gly Ser 
                325                 330                 335     


Ser Gly Arg Arg Lys Ala Lys Lys Lys Trp Arg Lys Asp Ser Pro Trp 
            340                 345                 350         


Val Lys Pro Ser Arg Lys Arg Arg Lys Arg Glu Pro Pro Arg Ala Lys 
        355                 360                 365             


Glu Pro Arg Gly Val Asn Gly Val Gly Ser Ser Gly Pro Ser Glu Tyr 
    370                 375                 380                 


Met Glu Val Pro Leu Gly Ser Leu Glu Leu Pro Ser Glu Gly Thr Leu 
385                 390                 395                 400 


Ser Pro Asn His Ala Gly Val Ser Asn Asp Thr Ser Ser Leu Glu Thr 
                405                 410                 415     


Glu Arg Gly Phe Glu Glu Leu Pro Leu Cys Ser Cys Arg Met Glu Ala 
            420                 425                 430         


Pro Lys Ile Asp Arg Ile Ser Glu Arg Ala Gly His Lys Cys Met Ala 
        435                 440                 445             


Thr Glu Ser Val Asp Gly Glu Leu Ser Gly Cys Asn Ala Ala Ile Leu 
    450                 455                 460                 


Lys Arg Glu Thr Met Arg Pro Ser Ser Arg Val Ala Leu Met Val Leu 
465                 470                 475                 480 


Cys Glu Thr His Arg Ala Arg Met Val Lys His His Cys Cys Pro Gly 
                485                 490                 495     


Cys Gly Tyr Phe Cys Thr Ala Gly Thr Phe Leu Glu Cys His Pro Asp 
            500                 505                 510         


Phe Arg Val Ala His Arg Phe His Lys Ala Cys Val Ser Gln Leu Asn 
        515                 520                 525             


Gly Met Val Phe Cys Pro His Cys Gly Glu Asp Ala Ser Glu Ala Gln 
    530                 535                 540                 


Glu Val Thr Ile Pro Arg Gly Asp Gly Val Thr Pro Pro Ala Gly Thr 
545                 550                 555                 560 


Ala Ala Pro Ala Pro Pro Pro Leu Ser Gln Asp Val Pro Gly Arg Ala 
                565                 570                 575     


Asp Thr Ser Gln Pro Ser Ala Arg Met Arg Gly His Gly Glu Pro Arg 
            580                 585                 590         


Arg Pro Pro Cys Asp Pro Leu Ala Asp Thr Ile Asp Ser Ser Gly Pro 
        595                 600                 605             


Ser Leu Thr Leu Pro Asn Gly Gly Cys Leu Ser Ala Val Gly Leu Pro 
    610                 615                 620                 


Leu Gly Pro Gly Arg Glu Ala Leu Glu Lys Ala Leu Val Ile Gln Glu 
625                 630                 635                 640 


Ser Glu Arg Arg Lys Lys Leu Arg Phe His Pro Arg Gln Leu Tyr Leu 
                645                 650                 655     


Ser Val Lys Gln Gly Glu Leu Gln Lys Val Ile Leu Met Leu Leu Asp 
            660                 665                 670         


Asn Leu Asp Pro Asn Phe Gln Ser Asp Gln Gln Ser Lys Arg Thr Pro 
        675                 680                 685             


Leu His Ala Ala Ala Gln Lys Gly Ser Val Glu Ile Cys His Val Leu 
    690                 695                 700                 


Leu Gln Ala Gly Ala Asn Ile Asn Ala Val Asp Lys Gln Gln Arg Thr 
705                 710                 715                 720 


Pro Leu Met Glu Ala Val Val Asn Asn His Leu Glu Val Ala Arg Tyr 
                725                 730                 735     


Met Val Gln Arg Gly Gly Cys Val Tyr Ser Lys Glu Glu Asp Gly Ser 
            740                 745                 750         


Thr Cys Leu His His Ala Ala Lys Ile Gly Asn Leu Glu Met Val Ser 
        755                 760                 765             


Leu Leu Leu Ser Thr Gly Gln Val Asp Val Asn Ala Gln Asp Ser Gly 
    770                 775                 780                 


Gly Trp Thr Pro Ile Ile Trp Ala Ala Glu His Lys His Ile Glu Val 
785                 790                 795                 800 


Ile Arg Met Leu Leu Thr Arg Gly Ala Asp Val Thr Leu Thr Asp Asn 
                805                 810                 815     


Glu Glu Asn Ile Cys Leu His Trp Ala Ser Phe Thr Gly Ser Ala Ala 
            820                 825                 830         


Ile Ala Glu Val Leu Leu Asn Ala Arg Cys Asp Leu His Ala Val Asn 
        835                 840                 845             


Tyr His Gly Asp Thr Pro Leu His Ile Ala Ala Arg Glu Ser Tyr His 
    850                 855                 860                 


Asp Cys Val Leu Leu Phe Leu Ser Arg Gly Ala Asn Pro Glu Leu Arg 
865                 870                 875                 880 


Asn Lys Glu Gly Asp Thr Ala Trp Asp Leu Thr Pro Glu Arg Ser Asp 
                885                 890                 895     


Val Trp Phe Ala Leu Gln Leu Asn Arg Lys Leu Arg Leu Gly Val Gly 
            900                 905                 910         


Asn Arg Ala Ile Arg Thr Glu Lys Ile Ile Cys Arg Asp Val Ala Arg 
        915                 920                 925             


Gly Tyr Glu Asn Val Pro Ile Pro Cys Val Asn Gly Val Asp Gly Glu 
    930                 935                 940                 


Pro Cys Pro Glu Asp Tyr Lys Tyr Ile Ser Glu Asn Cys Glu Thr Ser 
945                 950                 955                 960 


Thr Met Asn Ile Asp Arg Asn Ile Thr His Leu Gln His Cys Thr Cys 
                965                 970                 975     


Val Asp Asp Cys Ser Ser Ser Asn Cys Leu Cys Gly Gln Leu Ser Ile 
            980                 985                 990         


Arg Cys Trp Tyr Asp Lys Asp Gly  Arg Leu Leu Gln Glu  Phe Asn Lys 
        995                 1000                 1005             


Ile Glu  Pro Pro Leu Ile Phe  Glu Cys Asn Gln Ala  Cys Ser Cys 
    1010                 1015                 1020             


Trp Arg  Asn Cys Lys Asn Arg  Val Val Gln Ser Gly  Ile Lys Val 
    1025                 1030                 1035             


Arg Leu  Gln Leu Tyr Arg Thr  Ala Lys Met Gly Trp  Gly Val Arg 
    1040                 1045                 1050             


Ala Leu  Gln Thr Ile Pro Gln  Gly Thr Phe Ile Cys  Glu Tyr Val 
    1055                 1060                 1065             


Gly Glu  Leu Ile Ser Asp Ala  Glu Ala Asp Val Arg  Glu Asp Asp 
    1070                 1075                 1080             


Ser Tyr  Leu Phe Asp Leu Asp  Asn Lys Asp Gly Glu  Val Tyr Cys 
    1085                 1090                 1095             


Ile Asp  Ala Arg Tyr Tyr Gly  Asn Ile Ser Arg Phe  Ile Asn His 
    1100                 1105                 1110             


Leu Cys  Asp Pro Asn Ile Ile  Pro Val Arg Val Phe  Met Leu His 
    1115                 1120                 1125             


Gln Asp  Leu Arg Phe Pro Arg  Ile Ala Phe Phe Ser  Ser Arg Asp 
    1130                 1135                 1140             


Ile Arg  Thr Gly Glu Glu Leu  Gly Phe Asp Tyr Gly  Asp Arg Phe 
    1145                 1150                 1155             


Trp Asp  Ile Lys Ser Lys Tyr  Phe Thr Cys Gln Cys  Gly Ser Glu 
    1160                 1165                 1170             


Lys Cys  Lys His Ser Ala Glu  Ala Ile Ala Leu Glu  Gln Ser Arg 
    1175                 1180                 1185             


Leu Ala  Arg Leu Asp Pro His  Pro Glu Leu Leu Pro  Glu Leu Gly 
    1190                 1195                 1200             


Ser Leu  Pro Pro Val Asn Thr  
    1205                 1210 


