                         SEQUENCE LISTING

<110>  INSERM
       UNIVERSITE DE BORDEAUX
       ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL 
       UNIVERSITY
 
<120>  NOVEL RECOMBINANT FRAGMENTS OF FIBRILLIN-1 AND METHODS OF USE 
       THEREOF

<130>  2020-FIB-PCT

<140>  Not Yet Known
<141>  2021-12-20

<150>  EP20217170.8
<151>  2020-12-23

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  1239
<212>  PRT
<213>  HUMAN

<400>  1

Asp Val Asn Glu Cys Leu Asp Pro Thr Thr Cys Ile Ser Gly Asn Cys 
1               5                   10                  15      


Val Asn Thr Pro Gly Ser Tyr Ile Cys Asp Cys Pro Pro Asp Phe Glu 
            20                  25                  30          


Leu Asn Pro Thr Arg Val Gly Cys Val Asp Thr Arg Ser Gly Asn Cys 
        35                  40                  45              


Tyr Leu Asp Ile Arg Pro Arg Gly Asp Asn Gly Asp Thr Ala Cys Ser 
    50                  55                  60                  


Asn Glu Ile Gly Val Gly Val Ser Lys Ala Ser Cys Cys Cys Ser Leu 
65                  70                  75                  80  


Gly Lys Ala Trp Gly Thr Pro Cys Glu Met Cys Pro Ala Val Asn Thr 
                85                  90                  95      


Ser Glu Tyr Lys Ile Leu Cys Pro Gly Gly Glu Gly Phe Arg Pro Asn 
            100                 105                 110         


Pro Ile Thr Val Ile Leu Glu Asp Ile Asp Glu Cys Gln Glu Leu Pro 
        115                 120                 125             


Gly Leu Cys Gln Gly Gly Lys Cys Ile Asn Thr Phe Gly Ser Phe Gln 
    130                 135                 140                 


Cys Arg Cys Pro Thr Gly Tyr Tyr Leu Asn Glu Asp Thr Arg Val Cys 
145                 150                 155                 160 


Asp Asp Val Asn Glu Cys Glu Thr Pro Gly Ile Cys Gly Pro Gly Thr 
                165                 170                 175     


Cys Tyr Asn Thr Val Gly Asn Tyr Thr Cys Ile Cys Pro Pro Asp Tyr 
            180                 185                 190         


Met Gln Val Asn Gly Gly Asn Asn Cys Met Asp Met Arg Arg Ser Leu 
        195                 200                 205             


Cys Tyr Arg Asn Tyr Tyr Ala Asp Asn Gln Thr Cys Asp Gly Glu Leu 
    210                 215                 220                 


Leu Phe Asn Met Thr Lys Lys Met Cys Cys Cys Ser Tyr Asn Ile Gly 
225                 230                 235                 240 


Arg Ala Trp Asn Lys Pro Cys Glu Gln Cys Pro Ile Pro Ser Thr Asp 
                245                 250                 255     


Glu Phe Ala Thr Leu Cys Gly Ser Gln Arg Pro Gly Phe Val Ile Asp 
            260                 265                 270         


Ile Tyr Thr Gly Leu Pro Val Asp Ile Asp Glu Cys Arg Glu Ile Pro 
        275                 280                 285             


Gly Val Cys Glu Asn Gly Val Cys Ile Asn Met Val Gly Ser Phe Arg 
    290                 295                 300                 


Cys Glu Cys Pro Val Gly Phe Phe Tyr Asn Asp Lys Leu Leu Val Cys 
305                 310                 315                 320 


Glu Asp Ile Asp Glu Cys Gln Asn Gly Pro Val Cys Gln Arg Asn Ala 
                325                 330                 335     


Glu Cys Ile Asn Thr Ala Gly Ser Tyr Arg Cys Asp Cys Lys Pro Gly 
            340                 345                 350         


Tyr Arg Phe Thr Ser Thr Gly Gln Cys Asn Asp Arg Asn Glu Cys Gln 
        355                 360                 365             


Glu Ile Pro Asn Ile Cys Ser His Gly Gln Cys Ile Asp Thr Val Gly 
    370                 375                 380                 


Ser Phe Tyr Cys Leu Cys His Thr Gly Phe Lys Thr Asn Asp Asp Gln 
385                 390                 395                 400 


Thr Met Cys Leu Asp Ile Asn Glu Cys Glu Arg Asp Ala Cys Gly Asn 
                405                 410                 415     


Gly Thr Cys Arg Asn Thr Ile Gly Ser Phe Asn Cys Arg Cys Asn His 
            420                 425                 430         


Gly Phe Ile Leu Ser His Asn Asn Asp Cys Ile Asp Val Asp Glu Cys 
        435                 440                 445             


Ala Ser Gly Asn Gly Asn Leu Cys Arg Asn Gly Gln Cys Ile Asn Thr 
    450                 455                 460                 


Val Gly Ser Phe Gln Cys Gln Cys Asn Glu Gly Tyr Glu Val Ala Pro 
465                 470                 475                 480 


Asp Gly Arg Thr Cys Val Asp Ile Asn Glu Cys Leu Leu Glu Pro Arg 
                485                 490                 495     


Lys Cys Ala Pro Gly Thr Cys Gln Asn Leu Asp Gly Ser Tyr Arg Cys 
            500                 505                 510         


Ile Cys Pro Pro Gly Tyr Ser Leu Gln Asn Glu Lys Cys Glu Asp Ile 
        515                 520                 525             


Asp Glu Cys Val Glu Glu Pro Glu Ile Cys Ala Leu Gly Thr Cys Ser 
    530                 535                 540                 


Asn Thr Glu Gly Ser Phe Lys Cys Leu Cys Pro Glu Gly Phe Ser Leu 
545                 550                 555                 560 


Ser Ser Ser Gly Arg Arg Cys Gln Asp Leu Arg Met Ser Tyr Cys Tyr 
                565                 570                 575     


Ala Lys Phe Glu Gly Gly Lys Cys Ser Ser Pro Lys Ser Arg Asn His 
            580                 585                 590         


Ser Lys Gln Glu Cys Cys Cys Ala Leu Lys Gly Glu Gly Trp Gly Asp 
        595                 600                 605             


Pro Cys Glu Leu Cys Pro Thr Glu Pro Asp Glu Ala Phe Arg Gln Ile 
    610                 615                 620                 


Cys Pro Tyr Gly Ser Gly Ile Ile Val Gly Pro Asp Asp Ser Ala Val 
625                 630                 635                 640 


Asp Met Asp Glu Cys Lys Glu Pro Asp Val Cys Lys His Gly Gln Cys 
                645                 650                 655     


Ile Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Pro Phe Gly Tyr Thr 
            660                 665                 670         


Leu Ala Gly Asn Glu Cys Val Asp Thr Asp Glu Cys Ser Val Gly Asn 
        675                 680                 685             


Pro Cys Gly Asn Gly Thr Cys Lys Asn Val Ile Gly Gly Phe Glu Cys 
    690                 695                 700                 


Thr Cys Glu Glu Gly Phe Glu Pro Gly Pro Met Met Thr Cys Glu Asp 
705                 710                 715                 720 


Ile Asn Glu Cys Ala Gln Asn Pro Leu Leu Cys Ala Phe Arg Cys Val 
                725                 730                 735     


Asn Thr Tyr Gly Ser Tyr Glu Cys Lys Cys Pro Val Gly Tyr Val Leu 
            740                 745                 750         


Arg Glu Asp Arg Arg Met Cys Lys Asp Glu Asp Glu Cys Glu Glu Gly 
        755                 760                 765             


Lys His Asp Cys Thr Glu Lys Gln Met Glu Cys Lys Asn Leu Ile Gly 
    770                 775                 780                 


Thr Tyr Met Cys Ile Cys Gly Pro Gly Tyr Gln Arg Arg Pro Asp Gly 
785                 790                 795                 800 


Glu Gly Cys Val Asp Glu Asn Glu Cys Gln Thr Lys Pro Gly Ile Cys 
                805                 810                 815     


Glu Asn Gly Arg Cys Leu Asn Thr Arg Gly Ser Tyr Thr Cys Glu Cys 
            820                 825                 830         


Asn Asp Gly Phe Thr Ala Ser Pro Asn Gln Asp Glu Cys Leu Asp Asn 
        835                 840                 845             


Arg Glu Gly Tyr Cys Phe Thr Glu Val Leu Gln Asn Met Cys Gln Ile 
    850                 855                 860                 


Gly Ser Ser Asn Arg Asn Pro Val Thr Lys Ser Glu Cys Cys Cys Asp 
865                 870                 875                 880 


Gly Gly Arg Gly Trp Gly Pro His Cys Glu Ile Cys Pro Phe Gln Gly 
                885                 890                 895     


Thr Val Ala Phe Lys Lys Leu Cys Pro His Gly Arg Gly Phe Met Thr 
            900                 905                 910         


Asn Gly Ala Asp Ile Asp Glu Cys Lys Val Ile His Asp Val Cys Arg 
        915                 920                 925             


Asn Gly Glu Cys Val Asn Asp Arg Gly Ser Tyr His Cys Ile Cys Lys 
    930                 935                 940                 


Thr Gly Tyr Thr Pro Asp Ile Thr Gly Thr Ser Cys Val Asp Leu Asn 
945                 950                 955                 960 


Glu Cys Asn Gln Ala Pro Lys Pro Cys Asn Phe Ile Cys Lys Asn Thr 
                965                 970                 975     


Glu Gly Ser Tyr Gln Cys Ser Cys Pro Lys Gly Tyr Ile Leu Gln Glu 
            980                 985                 990         


Asp Gly Arg Ser Cys Lys Asp Leu  Asp Glu Cys Ala Thr  Lys Gln His 
        995                 1000                 1005             


Asn Cys  Gln Phe Leu Cys Val  Asn Thr Ile Gly Gly  Phe Thr Cys 
    1010                 1015                 1020             


Lys Cys  Pro Pro Gly Phe Thr  Gln His His Thr Ser  Cys Ile Asp 
    1025                 1030                 1035             


Asn Asn  Glu Cys Thr Ser Asp  Ile Asn Leu Cys Gly  Ser Lys Gly 
    1040                 1045                 1050             


Ile Cys  Gln Asn Thr Pro Gly  Ser Phe Thr Cys Glu  Cys Gln Arg 
    1055                 1060                 1065             


Gly Phe  Ser Leu Asp Gln Thr  Gly Ser Ser Cys Glu  Asp Val Asp 
    1070                 1075                 1080             


Glu Cys  Glu Gly Asn His Arg  Cys Gln His Gly Cys  Gln Asn Ile 
    1085                 1090                 1095             


Ile Gly  Gly Tyr Arg Cys Ser  Cys Pro Gln Gly Tyr  Leu Gln His 
    1100                 1105                 1110             


Tyr Gln  Trp Asn Gln Cys Val  Asp Glu Asn Glu Cys  Leu Ser Ala 
    1115                 1120                 1125             


His Ile  Cys Gly Gly Ala Ser  Cys His Asn Thr Leu  Gly Ser Tyr 
    1130                 1135                 1140             


Lys Cys  Met Cys Pro Ala Gly  Phe Gln Tyr Glu Gln  Phe Ser Gly 
    1145                 1150                 1155             


Gly Cys  Gln Asp Ile Asn Glu  Cys Gly Ser Ala Gln  Ala Pro Cys 
    1160                 1165                 1170             


Ser Tyr  Gly Cys Ser Asn Thr  Glu Gly Gly Tyr Leu  Cys Gly Cys 
    1175                 1180                 1185             


Pro Pro  Gly Tyr Phe Arg Ile  Gly Gln Gly His Cys  Val Ser Gly 
    1190                 1195                 1200             


Met Gly  Met Gly Arg Gly Asn  Pro Glu Pro Pro Val  Ser Gly Glu 
    1205                 1210                 1215             


Met Asp  Asp Asn Ser Leu Ser  Pro Glu Ala Cys Tyr  Glu Cys Lys 
    1220                 1225                 1230             


Ile Asn  Gly Tyr Pro Lys 
    1235                 


