                         SEQUENCE LISTING

<110>  BioNTech SE
 
<120>  THERAPEUTIC RNA FOR TREATING CANCER

<130>  674-372 PCT2

<150>  PCT/EP2020/087469
<151>  2020-12-21

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His 
145                 150         


<210>  2
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  3
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  4
<211>  772
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIL7-hAlb

<400>  4

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ala His Lys Ser 
            180                 185                 190         


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
        195                 200                 205             


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
    210                 215                 220                 


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
225                 230                 235                 240 


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
                245                 250                 255     


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
            260                 265                 270         


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
        275                 280                 285             


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
    290                 295                 300                 


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
305                 310                 315                 320 


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
                325                 330                 335     


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
            340                 345                 350         


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
        355                 360                 365             


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
    370                 375                 380                 


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
385                 390                 395                 400 


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
                405                 410                 415     


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
            420                 425                 430         


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
        435                 440                 445             


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
    450                 455                 460                 


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
465                 470                 475                 480 


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
                485                 490                 495     


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
            500                 505                 510         


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
        515                 520                 525             


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
    530                 535                 540                 


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
545                 550                 555                 560 


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
                565                 570                 575     


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
            580                 585                 590         


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
        595                 600                 605             


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
    610                 615                 620                 


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
625                 630                 635                 640 


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
                645                 650                 655     


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
            660                 665                 670         


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
        675                 680                 685             


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
    690                 695                 700                 


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
705                 710                 715                 720 


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
                725                 730                 735     


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
            740                 745                 750         


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
        755                 760                 765             


Ala Leu Gly Leu 
    770         


<210>  5
<211>  2801
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hIL7-hAlb

<400>  5
agacgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccauguucca       60

uguuucuuuu agguauaucu uuggacuucc uccccugauc cuuguucugu ugccaguagc      120

aucaucugau ugugauauug aagguaaaga uggcaaacaa uaugagagug uucuaauggu      180

cagcaucgau caauuauugg acagcaugaa agaaauuggu agcaauugcc ugaauaauga      240

auuuaacuuu uuuaaaagac auaucuguga ugcuaauaag gaagguaugu uuuuauuccg      300

ugcugcucgc aaguugaggc aauuucuuaa aaugaauagc acuggugauu uugaucucca      360

cuuauuaaaa guuucagaag gcacaacaau acuguugaac ugcacuggcc agguuaaagg      420

aagaaaacca gcugcccugg gugaagccca accaacaaag aguuuggaag aaaauaaauc      480

uuuaaaggaa cagaaaaaac ugaaugacuu guguuuccua aagagacuau uacaagagau      540

aaaaacuugu uggaauaaaa uuuugauggg cacuaaagaa cacggcggcu cuggaggagg      600

cggcuccgga ggcgaugcac acaagaguga gguugcucau cgcuuuaaag auuugggaga      660

agaaaauuuc aaagccuugg uguugauugc cuuugcucag uaucuucagc aguguccauu      720

ugaagaucau guaaaauuag ugaaugaagu aacugaauuu gcaaaaacau guguugcuga      780

ugagucagcu gaaaauugug acaaaucacu ucauacccuu uuuggagaca aauuaugcac      840

aguugcaaca cuucgugaaa ccuaugguga aauggcugac ugcugugcaa aacaagaacc      900

ugagagaaau gaaugcuucu ugcaacacaa agaugacaac ccaaaccucc cccgauuggu      960

gagaccagag guugauguga ugugcacugc uuuucaugac aaugaagaaa cauuuuugaa     1020

aaaauacuua uaugaaauug ccagaagaca uccuuacuuu uaugccccgg aacuccuuuu     1080

cuuugcuaaa agguauaaag cugcuuuuac agaauguugc caagcugcug auaaagcugc     1140

cugccuguug ccaaagcucg augaacuucg ggaugaaggg aaggcuucgu cugccaaaca     1200

gagacucaag ugugccaguc uccaaaaauu uggagaaaga gcuuucaaag caugggcagu     1260

agcucgccug agccagagau uucccaaagc ugaguuugca gaaguuucca aguuagugac     1320

agaucuuacc aaaguccaca cggaaugcug ccauggagau cugcuugaau gugcugauga     1380

cagggcggac cuugccaagu auaucuguga aaaucaagau ucgaucucca guaaacugaa     1440

ggaaugcugu gaaaaaccac uguuggaaaa aucccacugc auugccgaag uggaaaauga     1500

ugagaugccu gcugacuugc cuucauuagc ugcugauuuu guugaaagua aggauguuug     1560

caaaaacuau gcugaggcaa aggaugucuu ccugggcaug uuuuuguaug aauaugcaag     1620

aaggcauccu gauuacucug ucgugcugcu gcugagacuu gccaagacau augaaaccac     1680

ucuagagaag ugcugugccg cugcagaucc ucaugaaugc uaugccaaag uguucgauga     1740

auuuaaaccu cuuguggagg agccucagaa uuuaaucaaa caaaauugug agcuuuuuga     1800

gcagcuugga gaguacaaau uccagaaugc gcuauuaguu cguuacacca agaaaguacc     1860

ccaaguguca acuccaacuc uuguagaggu cucaagaaac cuaggaaaag ugggcagcaa     1920

auguuguaaa cauccugaag caaaaagaau gcccugugca gaagacuauc uauccguggu     1980

ccugaaccag uuaugugugu ugcaugagaa aacgccagua agugacagag ucaccaaaug     2040

cugcacagaa uccuugguga acaggcgacc augcuuuuca gcucuggaag ucgaugaaac     2100

auacguuccc aaagaguuua augcugaaac auucaccuuc caugcagaua uaugcacacu     2160

uucugagaag gagagacaaa ucaagaaaca aacugcacuu guugagcugg ugaaacacaa     2220

gcccaaggca acaaaagagc aacugaaagc uguuauggau gauuucgcag cuuuuguaga     2280

gaagugcugc aaggcugacg auaaggagac cugcuuugcc gaggagggua aaaaacuugu     2340

ugcugcaagu caagcugccu uaggcuuaug augacucgag cugguacugc augcacgcaa     2400

ugcuagcugc cccuuucccg uccuggguac cccgagucuc ccccgaccuc gggucccagg     2460

uaugcuccca ccuccaccug ccccacucac caccucugcu aguuccagac accucccaag     2520

cacgcagcaa ugcagcucaa aacgcuuagc cuagccacac ccccacggga aacagcagug     2580

auuaaccuuu agcaauaaac gaaaguuuaa cuaagcuaua cuaaccccag gguuggucaa     2640

uuucgugcca gccacaccga gaccuggucc agagucgcua gccgcgucgc uaaaaaaaaa     2700

aaaaaaaaaa aaaaaaaaaa agcauaugac uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2760

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         2801


<210>  6
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAlb-hIL2

<400>  6

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Pro Thr Ser Ser 
    610                 615                 620                 


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
625                 630                 635                 640 


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
                645                 650                 655     


Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu 
            660                 665                 670         


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val 
        675                 680                 685             


Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
    690                 695                 700                 


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
705                 710                 715                 720 


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
                725                 730                 735     


Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
            740                 745                 750         


<210>  7
<211>  2741
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hAlb-hIL2

<400>  7
agacgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccaugaagug       60

gguaaccuuu auuucccuuc uuuuucucuu uagcucggcu uauuccaggg guguguuucg      120

ucgagaugca cacaagagug agguugcuca ucgcuuuaaa gauuugggag aagaaaauuu      180

caaagccuug guguugauug ccuuugcuca guaucuucag caguguccau uugaagauca      240

uguaaaauua gugaaugaag uaacugaauu ugcaaaaaca uguguugcug augagucagc      300

ugaaaauugu gacaaaucac uucauacccu uuuuggagac aaauuaugca caguugcaac      360

acuucgugaa accuauggug aaauggcuga cugcugugca aaacaagaac cugagagaaa      420

ugaaugcuuc uugcaacaca aagaugacaa cccaaaccuc ccccgauugg ugagaccaga      480

gguugaugug augugcacug cuuuucauga caaugaagaa acauuuuuga aaaaauacuu      540

auaugaaauu gccagaagac auccuuacuu uuaugccccg gaacuccuuu ucuuugcuaa      600

aagguauaaa gcugcuuuua cagaauguug ccaagcugcu gauaaagcug ccugccuguu      660

gccaaagcuc gaugaacuuc gggaugaagg gaaggcuucg ucugccaaac agagacucaa      720

gugugccagu cuccaaaaau uuggagaaag agcuuucaaa gcaugggcag uagcucgccu      780

gagccagaga uuucccaaag cugaguuugc agaaguuucc aaguuaguga cagaucuuac      840

caaaguccac acggaaugcu gccauggaga ucugcuugaa ugugcugaug acagggcgga      900

ccuugccaag uauaucugug aaaaucaaga uucgaucucc aguaaacuga aggaaugcug      960

ugaaaaacca cuguuggaaa aaucccacug cauugccgaa guggaaaaug augagaugcc     1020

ugcugacuug ccuucauuag cugcugauuu uguugaaagu aaggauguuu gcaaaaacua     1080

ugcugaggca aaggaugucu uccugggcau guuuuuguau gaauaugcaa gaaggcaucc     1140

ugauuacucu gucgugcugc ugcugagacu ugccaagaca uaugaaacca cucuagagaa     1200

gugcugugcc gcugcagauc cucaugaaug cuaugccaaa guguucgaug aauuuaaacc     1260

ucuuguggag gagccucaga auuuaaucaa acaaaauugu gagcuuuuug agcagcuugg     1320

agaguacaaa uuccagaaug cgcuauuagu ucguuacacc aagaaaguac cccaaguguc     1380

aacuccaacu cuuguagagg ucucaagaaa ccuaggaaaa gugggcagca aauguuguaa     1440

acauccugaa gcaaaaagaa ugcccugugc agaagacuau cuauccgugg uccugaacca     1500

guuaugugug uugcaugaga aaacgccagu aagugacaga gucaccaaau gcugcacaga     1560

auccuuggug aacaggcgac caugcuuuuc agcucuggaa gucgaugaaa cauacguucc     1620

caaagaguuu aaugcugaaa cauucaccuu ccaugcagau auaugcacac uuucugagaa     1680

ggagagacaa aucaagaaac aaacugcacu uguugagcug gugaaacaca agcccaaggc     1740

aacaaaagag caacugaaag cuguuaugga ugauuucgca gcuuuuguag agaagugcug     1800

caaggcugac gauaaggaga ccugcuuugc cgaggagggu aaaaaacuug uugcugcaag     1860

ucaagcugcc uuaggcuuag gcggcucugg aggaggcggc uccggaggcg cuccaacauc     1920

uucuucaaca aagaaaacac agcuucagcu ugaacaccuu cuucuugauc uucagaugau     1980

ucugaaugga aucaacaauu acaaaaaucc aaaacugaca agaaugcuga cauuuaaauu     2040

uuacaugcca aagaaagcaa cagaacugaa acaccuucag ugccuugaag aagaacugaa     2100

accucuggaa gaagugcuga aucuggcuca gagcaaaaau uuucaccuga gaccaagaga     2160

ucugaucagc aacaucaaug ugauugugcu ggaacugaaa ggaucugaaa caacauucau     2220

gugugaauau gcugaugaaa cagcaacaau uguggaauuu cugaacagau ggauuacauu     2280

uugccaguca aucauuucaa cacugacaug augacucgag cugguacugc augcacgcaa     2340

ugcuagcugc cccuuucccg uccuggguac cccgagucuc ccccgaccuc gggucccagg     2400

uaugcuccca ccuccaccug ccccacucac caccucugcu aguuccagac accucccaag     2460

cacgcagcaa ugcagcucaa aacgcuuagc cuagccacac ccccacggga aacagcagug     2520

auuaaccuuu agcaauaaac gaaaguuuaa cuaagcuaua cuaaccccag gguuggucaa     2580

uuucgugcca gccacaccga gaccuggucc agagucgcua gccgcgucgc uaaaaaaaaa     2640

aaaaaaaaaa aaaaaaaaaa agcauaugac uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2700

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         2741


<210>  8
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sec

<400>  8

Met Arg Val Met Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser 
            20                  25      


<210>  9
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MITD

<400>  9

Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val Val Val Ile 
1               5                   10                  15      


Gly Ala Val Val Ala Thr Val Met Cys Arg Arg Lys Ser Ser Gly Gly 
            20                  25                  30          


Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly 
        35                  40                  45              


Ser Asp Val Ser Leu Thr Ala 
    50                  55  


<210>  10
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2P16

<400>  10

Lys Lys Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  15      


Leu Lys Lys Leu Gly Gly Gly Lys Arg Gly Gly Gly Lys Lys Met Thr 
            20                  25                  30          


Asn Ser Val Asp Asp Ala Leu Ile Asn Ser Thr Lys Ile Tyr Ser Tyr 
        35                  40                  45              


Phe Pro Ser Val Ile Ser Lys Val Asn Gln Gly Ala Gln Gly Lys Lys 
    50                  55                  60                  


Leu 
65  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS-Linker

<400>  11

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS-Linker

<400>  12

Gly Ser Ser Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Ser 
1               5                   10                  


<210>  13
<211>  47
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5'-UTR

<400>  13
aacuaguauu cuucuggucc ccacagacuc agagagaacc cgccacc                     47


<210>  14
<211>  278
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3'-UTR

<400>  14
cugguacugc augcacgcaa ugcuagcugc cccuuucccg uccuggguac cccgagucuc       60

ccccgaccuc gggucccagg uaugcuccca ccuccaccug ccccacucac caccucugcu      120

aguuccagac accucccaag cacgcagcaa ugcagcucaa aacgcuuagc cuagccacac      180

ccccacggga aacagcagug auuaaccuuu agcaauaaac gaaaguuuaa cuaagcuaua      240

cuaaccccag gguuggucaa uuucgugcca gccacacc                              278


<210>  15
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  A30L70

<400>  15
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa gcauaugacu aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                 110


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2

<400>  16

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15  


<210>  17
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P17

<400>  17

Met Thr Asn Ser Val Asp Asp Ala Leu Ile Asn Ser Thr Lys Ile Tyr 
1               5                   10                  15      


Ser Tyr Phe Pro Ser Val Ile Ser Lys Val Asn Gln Gly Ala Gln Gly 
            20                  25                  30          


