                         SEQUENCE LISTING

<110>  GlaxoSmithKline Intellectual Property Development Limited
 
<120>  Dosage regimen

<130>  PB67015

<150>  US63/128922
<151>  2020-12-22

<150>  US63/285513
<151>  2021-12-03

<150>  US63/220182
<151>  2021-07-09

<150>  US63/192854
<151>  2021-05-25

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length heavy chain

<400>  1

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Ser 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Ser Gly Gly Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Thr Ser Arg Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Pro Pro Ser Gly Leu Leu Arg Leu Asp Tyr Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr 
                245                 250                 255     


Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  2
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length light chain

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Val His Ser Phe Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  3
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence

<400>  3

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Ser 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Ser Gly Gly Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Thr Ser Arg Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Pro Pro Ser Gly Leu Leu Arg Leu Asp Tyr Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  4
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Val His Ser Phe Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  5

Gly Ser Ser Val His 
1               5   


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  6

Val Ile Trp Ala Ser Gly Gly Thr Asp Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  7

Asp Pro Pro Ser Gly Leu Leu Arg Leu Asp Tyr 
1               5                   10      


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  8

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  9

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  10

Gln Asn Val His Ser Phe Pro Phe Thr 
1               5                   


<210>  11
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  11

Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu Thr Leu Ala 
1               5                   10                  15      


Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu Thr Leu Arg 
            20                  25                  30          


Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr Glu Glu Ile 
        35                  40                  45              


Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln Gly Gly Thr 
    50                  55                  60                  


Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys Tyr Ile Asp 
65                  70                  75                  80  


Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val Asn Gln Phe 
                85                  90                  95      


Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr Glu Trp Ile 
            100                 105                 110         


Ile Glu Ser 
        115 


<210>  12
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro Pro Val Asn Phe 
1               5                   10                  15      


Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu Gln Trp Lys Pro 
            20                  25                  30          


Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu Tyr Gln Val Lys 
        35                  40                  45              


Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg Ile Thr Glu Ser 
    50                  55                  60                  


Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala Ser Val Arg Thr 
65                  70                  75                  80  


Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser Trp Ala Ser Ala 
                85                  90                  95      


Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser Ile Val Asn Leu 
            100                 105                 110         


Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser Arg Leu Arg Ser 
        115                 120                 125             


Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly Thr Asp Ala Pro 
    130                 135                 140                 


Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly Ser Trp Thr Glu 
145                 150                 155                 160 


Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg Asn Ile Ala Cys 
                165                 170                 175     


Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg Asp Trp Leu Ala 
            180                 185                 190         


Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile Arg Pro Phe Asp 
        195                 200                 205             


Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn Pro Pro Leu Asn 
    210                 215                 220                 


Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile Gln Trp Glu Lys 
225                 230                 235                 240 


Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr Glu Val Lys Ile 
                245                 250                 255     


His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys Leu Met Thr Asn 
            260                 265                 270         


Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr Asp Val Gln Val 
        275                 280                 285             


Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly Leu Trp Ser Glu 
    290                 295                 300                 


Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His Lys Pro Leu Arg 
305                 310                 315                 320 


Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys Phe Ile Leu Leu 
                325                 330                 335     


Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp Ile Lys Leu Phe 
            340                 345                 350         


Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp Leu Phe Val Thr 
        355                 360                 365             


Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu Ile Glu Val Ile 
    370                 375                 380                 


Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu Asp Ser Val Phe 
385                 390                 395                 400 


<210>  13
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding full length heavy chain with leader sequence

<400>  13
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggtgt gcacagccag       60

gtgaccctga gggagagcgg ccccgccctg gtgaagccca cacagaccct cactctgacc      120

tgcaccgtga gcggcttcag cctgaccggc tctagcgtcc actgggtgag gcagcccccc      180

ggcaagggcc tggagtggct gggcgtgatc tgggcaagcg gggggacgga ctacaactcg      240

gccctgatga gcaggctctc catcagcaag gacaccagcc ggaaccaggt ggtgctgacc      300

atgaccaaca tggaccccgt ggacaccgcc acctattact gcgccaggga ccctccctcc      360

ggcctgctga ggctggacta ctggggcagg ggaacactag tgaccgtgtc cagcgccagc      420

accaagggcc ccagcgtgtt ccccctggcc cccagcagca agagcaccag cggcggcaca      480

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gtcctggaac      540

agcggagccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      600

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc      660

tgtaacgtga accacaagcc cagcaacacc aaggtggaca agcgggtgga gcccaagagc      720

tgtgacaaga cccacacctg ccccccctgc cctgcccccg agctgctggg aggccccagc      780

gtgttcctgt tcccccccaa gcctaaggac accctgtaca tcaccagaga acccgaggtg      840

acctgtgtgg tggtggatgt gagccacgag gaccctgagg tgaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcacaa tgccaagacc aagcccaggg aggagcagta caacagcacc      960

taccgggtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaggagtac     1020

aagtgtaagg tgtccaacaa ggccctgcct gcccctatcg agaaaaccat cagcaaggcc     1080

aagggccagc ccagagagcc ccaggtgtac accctgcccc ctagcagaga ggagatgacc     1140

aagaaccagg tgtccctgac ctgcctggtg aagggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc tgtgctggac     1260

agcgatggca gcttcttcct gtacagcaag ctgaccgtgg acaagagcag atggcagcag     1320

ggcaacgtgt tcagctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag     1380

agcctgagcc tgtcccctgg caag                                            1404


<210>  14
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding full length light chain with leader sequence

<400>  14
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggtgt gcacagcgac       60

atcgtgatga cccagtctcc cgattcactg gccgtgagcc tgggcgagag ggccaccatc      120

aactgcaaga gcagccagag cctcctgaac agcggcaacc agaagaacta cctggcctgg      180

taccagcaga aacccggcca gccccccaag ctgctgatct atggcgcctc caccagggag      240

agcggcgtgc cagacaggtt tagcggcagc ggcagcggca ccgacttcac cctgacaatc      300

agcagcctgc aggccgagga cgtggccgtg tactactgcc agaacgtcca cagcttcccc      360

ttcaccttcg gcgggggaac caagctggag atcaagcgta cggtggccgc ccccagcgtg      420

ttcatcttcc cccccagcga tgagcagctg aagagcggca ccgccagcgt ggtgtgtctg      480

ctgaacaact tctacccccg ggaggccaag gtgcagtgga aggtggacaa tgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggacagca aggactccac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag      660

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaaccgggg cgagtgc         717


<210>  15
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding heavy chain variable region

<400>  15
caggtgaccc tgagggagag cggccccgcc ctggtgaagc ccacacagac cctcactctg       60

acctgcaccg tgagcggctt cagcctgacc ggctctagcg tccactgggt gaggcagccc      120

cccggcaagg gcctggagtg gctgggcgtg atctgggcaa gcggggggac ggactacaac      180

tcggccctga tgagcaggct ctccatcagc aaggacacca gccggaacca ggtggtgctg      240

accatgacca acatggaccc cgtggacacc gccacctatt actgcgccag ggaccctccc      300

tccggcctgc tgaggctgga ctactggggc aggggaacac tagtgaccgt gtccagc         357


<210>  16
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding light chain variable region

<400>  16
gacatcgtga tgacccagtc tcccgattca ctggccgtga gcctgggcga gagggccacc       60

atcaactgca agagcagcca gagcctcctg aacagcggca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg ccagcccccc aagctgctga tctatggcgc ctccaccagg      180

gagagcggcg tgccagacag gtttagcggc agcggcagcg gcaccgactt caccctgaca      240

atcagcagcc tgcaggccga ggacgtggcc gtgtactact gccagaacgt ccacagcttc      300

cccttcacct tcggcggggg aaccaagctg gagatcaagc gt                         342


<210>  17
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding full length heavy chain

<400>  17
caggtgaccc tgagggagag cggccccgcc ctggtgaagc ccacacagac cctcactctg       60

acctgcaccg tgagcggctt cagcctgacc ggctctagcg tccactgggt gaggcagccc      120

cccggcaagg gcctggagtg gctgggcgtg atctgggcaa gcggggggac ggactacaac      180

tcggccctga tgagcaggct ctccatcagc aaggacacca gccggaacca ggtggtgctg      240

accatgacca acatggaccc cgtggacacc gccacctatt actgcgccag ggaccctccc      300

tccggcctgc tgaggctgga ctactggggc aggggaacac tagtgaccgt gtccagcgcc      360

agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc      420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg      480

aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc      540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac      600

atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagcgggt ggagcccaag      660

agctgtgaca agacccacac ctgccccccc tgccctgccc ccgagctgct gggaggcccc      720

agcgtgttcc tgttcccccc caagcctaag gacaccctgt acatcaccag agaacccgag      780

gtgacctgtg tggtggtgga tgtgagccac gaggaccctg aggtgaagtt caactggtac      840

gtggacggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaacagc      900

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaggag      960

tacaagtgta aggtgtccaa caaggccctg cctgccccta tcgagaaaac catcagcaag     1020

gccaagggcc agcccagaga gccccaggtg tacaccctgc cccctagcag agaggagatg     1080

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc     1140

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg     1200

gacagcgatg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag     1260

cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag     1320

aagagcctga gcctgtcccc tggcaag                                         1347


<210>  18
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding full length light chain

<400>  18
gacatcgtga tgacccagtc tcccgattca ctggccgtga gcctgggcga gagggccacc       60

atcaactgca agagcagcca gagcctcctg aacagcggca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg ccagcccccc aagctgctga tctatggcgc ctccaccagg      180

gagagcggcg tgccagacag gtttagcggc agcggcagcg gcaccgactt caccctgaca      240

atcagcagcc tgcaggccga ggacgtggcc gtgtactact gccagaacgt ccacagcttc      300

cccttcacct tcggcggggg aaccaagctg gagatcaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain FR4 sequence

<400>  19

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


