                         SEQUENCE LISTING

<110>  CureVac AG
 
<120>  Pharmaceutical composition comprising lipid-based carriers 
       encapsulating RNA for multidose administration

<130>  CU01P327WO1

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike protein

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  3822
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike CDS

<400>  2
auguucgugu uccugguccu ccugccccug gugagcuccc agugcgugaa ccucaccacc       60

cgcacgcagc ugccgcccgc cuacaccaac agcuucaccc ggggcgucua cuaccccgac      120

aagguguucc gcuccagcgu gcugcacucc acccaggacc ucuuccugcc cuucuucagc      180

aacgucacgu gguuccacgc cauccacgug uccgggacca acggcaccaa gcgguucgac      240

aacccggugc ugcccuucaa cgacgggguc uacuucgcga gcaccgagaa guccaacauc      300

auccgcggcu ggaucuucgg gacgacccuc gacagcaaga cccagucccu gcugaucgug      360

aacaacgcca ccaacguggu caucaaggug ugcgaguucc aguucugcaa cgaccccuuc      420

cucggcgugu acuaccacaa gaacaacaag agcuggaugg aguccgaguu ccgggucuac      480

agcuccgcca acaacugcac guucgaguac gugagccagc ccuuccugau ggaccuggag      540

ggcaagcagg ggaacuucaa gaaccuccgc gaguucgugu ucaagaacau cgacggcuac      600

uucaagaucu acuccaagca caccccgauc aaccuggucc gggaccugcc ccagggguuc      660

agcgcccucg agccccuggu ggaccugccc aucggcauca acaucacccg cuuccagacc      720

cuccuggccc ugcaccgguc cuaccucacg ccgggggaca gcagcuccgg cuggaccgcg      780

ggcgccgccg ccuacuacgu gggguaccug cagccccgca ccuuccugcu caaguacaac      840

gagaacggca ccaucacgga cgcggucgac ugcgcccugg acccccugag cgagaccaag      900

ugcacccuca aguccuucac cguggagaag gggaucuacc agacgagcaa cuuccgggug      960

cagcccaccg aguccaucgu ccgcuucccg aacaucacca accugugccc cuucggcgag     1020

guguucaacg ccacccgguu cgccagcguc uacgccugga accgcaagcg gaucuccaac     1080

ugcguggcgg acuacagcgu gcuguacaac uccgccagcu ucuccacguu caagugcuac     1140

ggcgucagcc ccaccaagcu caacgaccug ugcuucacca acguguacgc cgacuccuuc     1200

gugauccgcg gggacgaggu ccggcagauc gcccccggcc agaccgggaa gaucgccgac     1260

uacaacuaca agcugccgga cgacuucacg ggcugcguga ucgcguggaa cagcaacaac     1320

cucgacucca aggucggggg caacuacaac uaccuguacc gccuguuccg caagagcaac     1380

cucaagcccu ucgagcggga caucuccacc gagaucuacc aggccggcag cacccccugc     1440

aacggggugg agggcuucaa cugcuacuuc ccccugcagu ccuacggguu ccagccgacc     1500

aacggcgugg gguaccagcc cuaccgggug gucgugcuga gcuucgagcu ccugcacgcc     1560

cccgccacgg ugugcggccc caagaagucc accaaccugg ucaagaacaa gugcgugaac     1620

uucaacuuca acggccucac cgggaccggc gugcugaccg agagcaacaa gaaguuccug     1680

ccguuccagc aguucgggcg cgacaucgcc gacacgaccg acgcgguccg cgacccccag     1740

acccuggaga uccucgacau cacccccugc agcuucggcg ggguguccgu gaucacgccg     1800

ggcaccaaca ccagcaacca ggucgccgug cuguaccagg acgugaacug caccgagguc     1860

cccguggcca uccacgccga ccagcugacg cccaccuggc ggguguacuc caccggcagc     1920

aacgucuucc agacccgcgc cgggugccuc aucggcgcgg agcacgugaa caacuccuac     1980

gagugcgaca uccccaucgg ggccggcauc ugcgccagcu accagacgca gaccaacucc     2040

ccgcggcgcg cccggagcgu ggcgucccag agcaucaucg ccuacaccau gucccugggc     2100

gccgagaaca gcgucgccua cuccaacaac agcaucgcca uccccaccaa cuucacgauc     2160

uccgugacca ccgagauccu gcccgugagc augaccaaga cgagcgucga cugcaccaug     2220

uacaucugcg gggacuccac cgagugcagc aaccuccugc ugcaguacgg cuccuucugc     2280

acccagcuca accgcgcgcu gacggggauc gccguggagc aggacaagaa cacccaggag     2340

guguucgccc aggucaagca gaucuacaag acgcccccga ucaaggacuu cggcggguuc     2400

aacuucagcc agauccugcc cgaccccucc aagcccagca agcgguccuu caucgaggac     2460

cuccuguuca acaaggugac ccuggccgac gccggcuuca ucaagcagua cggcgacugc     2520

cucggggaca ucgcggcccg cgaccugauc ugcgcccaga aguucaacgg ccugaccgug     2580

cucccgcccc ugcugaccga cgagaugauc gcccaguaca ccagcgcccu ccuggcgggg     2640

accaucacgu ccggcuggac cuucggggcc ggcgccgccc ugcagauccc cuucgcgaug     2700

cagauggccu accgguucaa cggcaucggg gucacccaga acgugcucua cgagaaccag     2760

aagcugaucg ccaaccaguu caacagcgcc aucggcaaga uccaggacuc ccugagcucc     2820

accgccagcg cgcucgggaa gcugcaggac guggucaacc agaacgccca ggcccugaac     2880

acgcucguga agcagcuguc cagcaacuuc ggcgccaucu ccagcgugcu gaacgacauc     2940

cucucccgcc uggacccgcc cgaggccgag gugcagaucg accggcugau caccgggcgc     3000

cuccagagcc ugcagaccua cgugacccag cagcugaucc gggcggccga gauccgcgcc     3060

agcgccaacc ucgccgcgac caagaugucc gagugcgucc ugggccagag caagcgggug     3120

gacuucugcg gcaaggggua ccaccugaug uccuuccccc agagcgcccc gcacggcgug     3180

gucuuccucc acgugacgua cguccccgcc caggagaaga acuucaccac cgcccccgcg     3240

aucugccacg acgggaaggc ccacuucccc cgcgagggcg uguucguguc caacgggacc     3300

cacugguucg ucacgcagcg gaacuucuac gagccgcaga ucaucaccac cgacaacacc     3360

uucgugagcg gcaacugcga cguggucauc ggcaucguga acaacacggu guacgacccc     3420

cugcagcccg agcuggacuc cuucaaggag gagcucgaca aguacuucaa gaaccacacc     3480

agccccgacg ucgaccuggg ggacaucucc ggcaucaacg ccagcguggu gaacauccag     3540

aaggagaucg accgccugaa cgaggucgcc aagaaccuca acgagucccu gaucgaccug     3600

caggagcucg ggaaguacga gcaguacauc aaguggccgu gguacaucug gcugggcuuc     3660

aucgccggcc ugaucgcgau cgugauggug accaucaugc ucugcugcau gaccagcugc     3720

ugcuccugcc ugaaggggug cugcagcugc ggcuccugcu gcaaguucga cgaggacgac     3780

agcgagcccg uccugaaggg ggugaagcuc cacuacacgu ga                        3822


<210>  3
<211>  4039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike mRNA R9515

<400>  3
aggagaaagc uuaccauguu cguguuccug guccuccugc cccuggugag cucccagugc       60

gugaaccuca ccacccgcac gcagcugccg cccgccuaca ccaacagcuu cacccggggc      120

gucuacuacc ccgacaaggu guuccgcucc agcgugcugc acuccaccca ggaccucuuc      180

cugcccuucu ucagcaacgu cacgugguuc cacgccaucc acguguccgg gaccaacggc      240

accaagcggu ucgacaaccc ggugcugccc uucaacgacg gggucuacuu cgcgagcacc      300

gagaagucca acaucauccg cggcuggauc uucgggacga cccucgacag caagacccag      360

ucccugcuga ucgugaacaa cgccaccaac guggucauca aggugugcga guuccaguuc      420

ugcaacgacc ccuuccucgg cguguacuac cacaagaaca acaagagcug gauggagucc      480

gaguuccggg ucuacagcuc cgccaacaac ugcacguucg aguacgugag ccagcccuuc      540

cugauggacc uggagggcaa gcaggggaac uucaagaacc uccgcgaguu cguguucaag      600

aacaucgacg gcuacuucaa gaucuacucc aagcacaccc cgaucaaccu gguccgggac      660

cugccccagg gguucagcgc ccucgagccc cugguggacc ugcccaucgg caucaacauc      720

acccgcuucc agacccuccu ggcccugcac cgguccuacc ucacgccggg ggacagcagc      780

uccggcugga ccgcgggcgc cgccgccuac uacguggggu accugcagcc ccgcaccuuc      840

cugcucaagu acaacgagaa cggcaccauc acggacgcgg ucgacugcgc ccuggacccc      900

cugagcgaga ccaagugcac ccucaagucc uucaccgugg agaaggggau cuaccagacg      960

agcaacuucc gggugcagcc caccgagucc aucguccgcu ucccgaacau caccaaccug     1020

ugccccuucg gcgagguguu caacgccacc cgguucgcca gcgucuacgc cuggaaccgc     1080

aagcggaucu ccaacugcgu ggcggacuac agcgugcugu acaacuccgc cagcuucucc     1140

acguucaagu gcuacggcgu cagccccacc aagcucaacg accugugcuu caccaacgug     1200

uacgccgacu ccuucgugau ccgcggggac gagguccggc agaucgcccc cggccagacc     1260

gggaagaucg ccgacuacaa cuacaagcug ccggacgacu ucacgggcug cgugaucgcg     1320

uggaacagca acaaccucga cuccaagguc gggggcaacu acaacuaccu guaccgccug     1380

uuccgcaaga gcaaccucaa gcccuucgag cgggacaucu ccaccgagau cuaccaggcc     1440

ggcagcaccc ccugcaacgg gguggagggc uucaacugcu acuucccccu gcaguccuac     1500

ggguuccagc cgaccaacgg cgugggguac cagcccuacc ggguggucgu gcugagcuuc     1560

gagcuccugc acgcccccgc cacggugugc ggccccaaga aguccaccaa ccuggucaag     1620

aacaagugcg ugaacuucaa cuucaacggc cucaccggga ccggcgugcu gaccgagagc     1680

aacaagaagu uccugccguu ccagcaguuc gggcgcgaca ucgccgacac gaccgacgcg     1740

guccgcgacc cccagacccu ggagauccuc gacaucaccc ccugcagcuu cggcggggug     1800

uccgugauca cgccgggcac caacaccagc aaccaggucg ccgugcugua ccaggacgug     1860

aacugcaccg agguccccgu ggccauccac gccgaccagc ugacgcccac cuggcgggug     1920

uacuccaccg gcagcaacgu cuuccagacc cgcgccgggu gccucaucgg cgcggagcac     1980

gugaacaacu ccuacgagug cgacaucccc aucggggccg gcaucugcgc cagcuaccag     2040

acgcagacca acuccccgcg gcgcgcccgg agcguggcgu cccagagcau caucgccuac     2100

accauguccc ugggcgccga gaacagcguc gccuacucca acaacagcau cgccaucccc     2160

accaacuuca cgaucuccgu gaccaccgag auccugcccg ugagcaugac caagacgagc     2220

gucgacugca ccauguacau cugcggggac uccaccgagu gcagcaaccu ccugcugcag     2280

uacggcuccu ucugcaccca gcucaaccgc gcgcugacgg ggaucgccgu ggagcaggac     2340

aagaacaccc aggagguguu cgcccagguc aagcagaucu acaagacgcc cccgaucaag     2400

gacuucggcg gguucaacuu cagccagauc cugcccgacc ccuccaagcc cagcaagcgg     2460

uccuucaucg aggaccuccu guucaacaag gugacccugg ccgacgccgg cuucaucaag     2520

caguacggcg acugccucgg ggacaucgcg gcccgcgacc ugaucugcgc ccagaaguuc     2580

aacggccuga ccgugcuccc gccccugcug accgacgaga ugaucgccca guacaccagc     2640

gcccuccugg cggggaccau cacguccggc uggaccuucg gggccggcgc cgcccugcag     2700

auccccuucg cgaugcagau ggccuaccgg uucaacggca ucggggucac ccagaacgug     2760

cucuacgaga accagaagcu gaucgccaac caguucaaca gcgccaucgg caagauccag     2820

gacucccuga gcuccaccgc cagcgcgcuc gggaagcugc aggacguggu caaccagaac     2880

gcccaggccc ugaacacgcu cgugaagcag cuguccagca acuucggcgc caucuccagc     2940

gugcugaacg acauccucuc ccgccuggac ccgcccgagg ccgaggugca gaucgaccgg     3000

cugaucaccg ggcgccucca gagccugcag accuacguga cccagcagcu gauccgggcg     3060

gccgagaucc gcgccagcgc caaccucgcc gcgaccaaga uguccgagug cguccugggc     3120

cagagcaagc ggguggacuu cugcggcaag ggguaccacc ugauguccuu cccccagagc     3180

gccccgcacg gcguggucuu ccuccacgug acguacgucc ccgcccagga gaagaacuuc     3240

accaccgccc ccgcgaucug ccacgacggg aaggcccacu ucccccgcga gggcguguuc     3300

guguccaacg ggacccacug guucgucacg cagcggaacu ucuacgagcc gcagaucauc     3360

accaccgaca acaccuucgu gagcggcaac ugcgacgugg ucaucggcau cgugaacaac     3420

acgguguacg acccccugca gcccgagcug gacuccuuca aggaggagcu cgacaaguac     3480

uucaagaacc acaccagccc cgacgucgac cugggggaca ucuccggcau caacgccagc     3540

guggugaaca uccagaagga gaucgaccgc cugaacgagg ucgccaagaa ccucaacgag     3600

ucccugaucg accugcagga gcucgggaag uacgagcagu acaucaagug gccgugguac     3660

aucuggcugg gcuucaucgc cggccugauc gcgaucguga uggugaccau caugcucugc     3720

ugcaugacca gcugcugcuc cugccugaag gggugcugca gcugcggcuc cugcugcaag     3780

uucgacgagg acgacagcga gcccguccug aaggggguga agcuccacua cacgugagga     3840

cuaguuauaa gacugacuag cccgaugggc cucccaacgg gcccuccucc ccuccuugca     3900

ccgagauuaa uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     4020

uuucagagcc accagaauu                                                  4039


<210>  4
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RABV-G protein

<400>  4

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Met Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Gly Gly 
                165                 170                 175     


Asn Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Gly Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Val Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asn Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Glu Arg Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Trp 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Gly Leu 
        515                 520                 


<210>  5
<211>  1575
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RABV-G CDS

<400>  5
auggugcccc aggcccugcu cuucgucccg cugcuggugu ucccccucug cuucggcaag       60

uuccccaucu acaccauccc cgacaagcug gggccgugga gccccaucga cauccaccac      120

cuguccugcc ccaacaaccu cguggucgag gacgagggcu gcaccaaccu gagcggguuc      180

uccuacaugg agcugaaggu gggcuacauc agcgccauca agaugaacgg guucacgugc      240

accggcgugg ucaccgaggc ggagaccuac acgaacuucg ugggcuacgu gaccaccacc      300

uucaagcgga agcacuuccg ccccacgccg gacgccugcc gggccgccua caacuggaag      360

auggccgggg acccccgcua cgaggagucc cuccacaacc ccuaccccga cuaccacugg      420

cugcggaccg ucaagaccac caaggagagc cuggugauca ucuccccgag cguggcggac      480

cucgaccccu acgaccgcuc ccugcacagc cgggucuucc ccggcgggaa cugcuccggc      540

guggccguga gcuccacgua cugcagcacc aaccacgacu acaccaucug gaugcccgag      600

aacccgcgcc uggggauguc cugcgacauc uucaccaaca gccggggcaa gcgcgccucc      660

aagggcagcg agacgugcgg guucgucgac gagcggggcc ucuacaaguc ccugaagggg      720

gccugcaagc ugaagcucug cggcgugcug ggccugcgcc ucauggacgg gaccugggug      780

gcgaugcaga ccagcaacga gaccaagugg ugcccccccg gccagcuggu caaccugcac      840

gacuuccgga gcgacgagau cgagcaccuc gugguggagg agcuggucaa gaagcgcgag      900

gagugccugg acgcccucga guccaucaug acgaccaaga gcguguccuu ccggcgccug      960

agccaccugc ggaagcucgu gcccggguuc ggcaaggccu acaccaucuu caacaagacc     1020

cugauggagg ccgacgccca cuacaagucc guccgcacgu ggaacgagau caucccgagc     1080

aaggggugcc ugcggguggg cggccgcugc cacccccacg ucaacggggu guucuucaac     1140

ggcaucaucc ucgggcccga cggcaacgug cugauccccg agaugcaguc cagccugcuc     1200

cagcagcaca uggagcugcu ggucuccagc gugaucccgc ucaugcaccc ccuggcggac     1260

cccuccaccg uguucaagaa cggggacgag gccgaggacu ucgucgaggu gcaccugccc     1320

gacgugcacg agcggaucag cggcgucgac cucggccugc cgaacugggg gaaguacgug     1380

cugcucuccg ccggcgcccu gaccgcccug augcugauca ucuuccucau gaccugcugg     1440

cgccggguga accggagcga gcccacgcag cacaaccugc gcgggaccgg ccgggagguc     1500

uccgugaccc cgcagagcgg gaagaucauc uccagcuggg aguccuacaa gagcggcggc     1560

gagaccgggc uguga                                                      1575


<210>  6
<211>  1792
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RABV-G mRNA R1803

<400>  6
gggagaaagc uuaccauggu gccccaggcc cugcucuucg ucccgcugcu gguguucccc       60

cucugcuucg gcaaguuccc caucuacacc auccccgaca agcuggggcc guggagcccc      120

aucgacaucc accaccuguc cugccccaac aaccucgugg ucgaggacga gggcugcacc      180

aaccugagcg gguucuccua cauggagcug aaggugggcu acaucagcgc caucaagaug      240

aacggguuca cgugcaccgg cguggucacc gaggcggaga ccuacacgaa cuucgugggc      300

uacgugacca ccaccuucaa gcggaagcac uuccgcccca cgccggacgc cugccgggcc      360

gccuacaacu ggaagauggc cggggacccc cgcuacgagg agucccucca caaccccuac      420

cccgacuacc acuggcugcg gaccgucaag accaccaagg agagccuggu gaucaucucc      480

ccgagcgugg cggaccucga ccccuacgac cgcucccugc acagccgggu cuuccccggc      540

gggaacugcu ccggcguggc cgugagcucc acguacugca gcaccaacca cgacuacacc      600

aucuggaugc ccgagaaccc gcgccugggg auguccugcg acaucuucac caacagccgg      660

ggcaagcgcg ccuccaaggg cagcgagacg ugcggguucg ucgacgagcg gggccucuac      720

aagucccuga agggggccug caagcugaag cucugcggcg ugcugggccu gcgccucaug      780

gacgggaccu ggguggcgau gcagaccagc aacgagacca aguggugccc ccccggccag      840

cuggucaacc ugcacgacuu ccggagcgac gagaucgagc accucguggu ggaggagcug      900

gucaagaagc gcgaggagug ccuggacgcc cucgagucca ucaugacgac caagagcgug      960

uccuuccggc gccugagcca ccugcggaag cucgugcccg gguucggcaa ggccuacacc     1020

aucuucaaca agacccugau ggaggccgac gcccacuaca aguccguccg cacguggaac     1080

gagaucaucc cgagcaaggg gugccugcgg gugggcggcc gcugccaccc ccacgucaac     1140

gggguguucu ucaacggcau cauccucggg cccgacggca acgugcugau ccccgagaug     1200

caguccagcc ugcuccagca gcacauggag cugcuggucu ccagcgugau cccgcucaug     1260

cacccccugg cggaccccuc caccguguuc aagaacgggg acgaggccga ggacuucguc     1320

gaggugcacc ugcccgacgu gcacgagcgg aucagcggcg ucgaccucgg ccugccgaac     1380

ugggggaagu acgugcugcu cuccgccggc gcccugaccg cccugaugcu gaucaucuuc     1440

cucaugaccu gcuggcgccg ggugaaccgg agcgagccca cgcagcacaa ccugcgcggg     1500

accggccggg aggucuccgu gaccccgcag agcgggaaga ucaucuccag cugggagucc     1560

uacaagagcg gcggcgagac cgggcuguga ggacuaguua uaagacugac uagcccgaug     1620

ggccucccaa cgggcccucc uccccuccuu gcaccgagau uaauaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaug cauccccccc     1740

cccccccccc cccccccccc ccccaaaggc ucuuuucaga gccaccagaa uu             1792


