                         SEQUENCE LISTING

<110>  ProBioGen AG
 
<120>  USE OF A BIRNAVIRUS ALONE OR IN COMBINATION THERAPY FOR THE 
       TREATMENT OF A DISEASE CAUSED BY A NIDOVIRUS

<130>  513-36 PCT

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  3258
<212>  DNA
<213>  IBDV strain R903/78 segment A

<400>  1
ggatacgatc ggtctgaccc cgggggagtc acccggggac aggccgtcaa ggctttgttc       60

caggatggaa ctcctccttc tacaacgcta tcattgatgg tcagtagaga tcagacaaac      120

gatcgcagcg atgacaaacc tgcaagatca aacccaacag attgttccgt tcatacggag      180

ccttctgatg ccaacaaccg gaccggcgtc cattccggac gacaccctgg agaagcacac      240

tctcaggtca gagacctcga cctacaattt gactgtgggg gacacagggt cagggctaat      300

tgtctttttc cctggattcc ctggctcaat tgtgggtgct cactacacac tgcagagcaa      360

tgggaactac aagttcgatc agatgctcct gactgcccag aacctaccgg ccagttacaa      420

ctactgcagg ctagtgagtc ggagtctcac agtgaggtca agcacacttc ctggtggcgt      480

ttatgcacta aacggcacca taaacgccgt gaccttccaa ggaagcctga gtgaactgac      540

agatgttagc tacaatgggt tgatgtctgc aacagccaac atcaacgaca aaattgggaa      600

cgtcctagta ggggaagggg tcaccgtcct cagcttaccc acatcatatg atcttgggta      660

tgtgaggctt ggtgacccca ttcccgcaat agggcttgac ccaaaaatgg tagccacatg      720

tgacagcagt gacaggccca gagtctacac cataactgca gccgatgatt accaattctc      780

atcacagtac caaccaggtg gggtaacaat cacactgttc tcagccaaca ttgatgccat      840

cacaagcctc agcgttgggg gagagctcgt gtttcaaaca agcgtccacg gcattgtact      900

gggcgccacc atctacctca taggctttga tgggacagcg gtaatcacca gggctgtggc      960

cgcaaacaat gggctgacga ccggcaccga caaccttatg ccattcaatc ttgtgattcc     1020

aacaaacgag ataacccagc caatcacatc catcaaactg gagatagtga cctccaaaag     1080

tggtggtcag gcaggggatc agatgtcatg gtcggcaaga gggagcctag cagtgacgat     1140

ccatggtggc aactatccag gggccctccg tcccgtcacg ctagtggcct acgaaagagt     1200

ggcaacagga tccgtcgtta cggtcgctgg ggtgagcaac ttcgagctga tcccaaatcc     1260

tgaactagca aagaacctgg ttacagaata cggccgattt gacccaggag ccatgaacta     1320

cacaaaattg atactgagtg agagggaccg tcttggcatc aagaccgtct ggccaacaag     1380

ggagtacact gactttcgtg aatacttcat ggaggtggcc gacctcaact ctcccctgaa     1440

gattgcagga gccttcggct tcaaagacat aatccgggcc ataaggagga tagctgtgcc     1500

ggtggtctcc acattgttcc cacctgccgc tcccctagcc catgcaattg gggaaggtgt     1560

agactacctg ctgggcgatg aggcacaggc tgcttcagga actgctcgag ccgcgtcagg     1620

aaaagcaaga gctgcctcag gccgcataag gcagctgact ctcgccgccg acaaggggta     1680

cgaggtagtc gcgaatctat tccaggtgcc ccagaatccc gtagtcgacg ggattcttgc     1740

ttcacctggg gtactccgcg gtgcacacaa cctcgactgc gtgttaagag agggtgccac     1800

gctattccct gtggttatta cgacagtgga agacgccatg acacccaaag cattgaacag     1860

caaaatgttt gctgtcattg aaggcgtgcg agaagacctc caacctccat ctcaaagagg     1920

atccttcata cgaactctct ctggacacag agtctatgga tatgctccag atggggtact     1980

tccactggag actgggagag actacaccgt tgtcccaata gatgatgtct gggacgacag     2040

cattatgctg tccaaagatc ccatacctcc tattgtggga aacagtggaa atctagccat     2100

agcttacatg gatgtgtttc gacccaaagt cccaatccat gtggctatga cgggagccct     2160

caatgcttgt ggcgagattg agaaagtaag ctttagaagc accaagctcg ccactgcaca     2220

ccgacttggc cttaagttgg ctggtcccgg agcattcgat gtaaacaccg ggcccaactg     2280

ggcaacgttc atcaaacgtt tccctcacaa tccacgcgac tgggacaggc tcccctacct     2340

caacctacca taccttccac ccaatgcagg acgccagtac caccttgcca tggctgcatc     2400

agagttcaaa gagacccccg aactcgagag tgccgtcaga gcaatggaag cagcagccaa     2460

cgtggaccca ctattccaat ctgcactcag tgtgttcatg tggctggaag agaatgggat     2520

tgtgactgac atggccaact tcgcactcag cgacccgaac gcccatcgga tgcgaaattt     2580

tcttgcaaac gcaccacaag caggcagcaa gtcgcaaagg gccaagtacg ggacagcagg     2640

ctacggagtg gaggctcggg gccccacacc agaggaagca cagagggaaa aagacacacg     2700

gatctcaaag aagatggaga ccatgggcat ctactttgca acaccagaat gggtagcact     2760

caatgggcac cgagggccaa gccccggcca gctaaagtac tggcagaaca cacgagaaat     2820

accggaccca aacgaggact atctagacta cgtgcatgca gagaagagcc ggttggcatc     2880

agaagaacaa atcctaaggg cagctacgtc gatctacggg gctccaggac aggcagagcc     2940

accccaagct ttcatagacg aagttgccaa agtctatgaa atcaaccatg gacgtggccc     3000

aaaccaagaa cagatgaaag atctgctctt gactgcgatg gagatgaagc atcgcaatcc     3060

caggcgggct ctaccaaagc ccaagccaaa acccaatgct ccaacacaga gaccccctgg     3120

tcggctgggc cgctggatca ggaccgtctc tgatgaggac cttgagtgag gctcctggga     3180

gtctcccgac accacccgcg caggtgtgga caccaattcg gccttacaac ccaaattgga     3240

tccgttcgcg ggtcccct                                                   3258


<210>  2
<211>  2827
<212>  DNA
<213>  IBDV strain R903/78 segment B

<400>  2
ggatacgatg ggtttgaccc tcagggagtc acgaattaac atggctacta ggggcgatac       60

ccgccgctgg ctgccacgtt agtggctcct cttcttgatg attctgccac catgagtgac      120

attttcaaca gtccacaggc gcgaagcacg atctcagcag cgttcggcat aaagcctact      180

gctggacaag acgtggaaga actcttgatc cctaaagttt gggtgccacc tgaggatccg      240

cttgccagcc ctagtcgact ggcaaagttc ctcagagaga acggctacaa agttttgcag      300

ccacggtctc tgcccgagaa tgaggagtat gagaccgacc aaatactccc agacttagca      360

tggatgcgac agatagaagg ggctgtttta aaacccactc tatctctccc tattggagat      420

caggagtact tcccaaagta ctacccaaca catcgcccta gcaaggagaa gcccaatgcg      480

tacccgccag acatcgcact actcaagcag atgatttacc tgtttctcca ggttccagag      540

gccaacgagg gcctaaagga tgaagtaacc ctcttgaccc aaaacataag ggacaaggcc      600

tatggaagtg ggacctacat gggacaagca actcgacttg tggccatgaa ggaggtcgcc      660

actggaagaa acccaaacaa ggatcctcta aagcttgggt acacttttga gagcatcgcg      720

cagctacttg acatcacact accggtaggc ccacccggtg aggatgacaa gccctgggtg      780

ccactcacaa gagtgccgtc acggatgttg gtgctgacgg gagacgtaga tggcgacttt      840

gaggttgaag attaccttcc caaaatcaac ctcaagtcat caagtggact accatatgta      900

ggtcgcacca aaggagagac aattggcgag atgatagcta tctcaaacca gtttctcaga      960

gagctatcaa cactgttgaa gcaaggtgca gggacaaagg ggtcaaacaa gaagaagcta     1020

ctcagcatgt taagtgacta ttggtactta tcatgcgggc ttttgtttcc aaaggctgaa     1080

aggtacgaca aaagcacatg gctcaccaag acccggaaca tatggtcagc tccatcccca     1140

acacacctca tgatctctat gatcacctgg cccgtgatgt ccaacagccc aaataacgtg     1200

ttgaacattg aagggtgtcc atcactctac aaattcaacc cgttcagagg agggttgaac     1260

aggatcgtcg agtggatatt ggccccggaa gaacccaagg ctcttgtata tgcggacaac     1320

atatacattg tccactcaaa cacgtggtac tcaattgacc tagagaaggg tgaggcaaac     1380

tgcactcgcc aacacatgca agccgcaatg tactacatac tcaccagagg gtggtcagac     1440

aacggcgacc caatgttcaa tcaaacatgg gccacctttg ccatgaacat tgcccctgct     1500

ctagtggtgg actcatcgtg cctgataatg aacctgcaaa ttaagaccta tggtcaaggc     1560

agcgggaatg cagccacgtt catcaacaac cacctcttga gcacgctagt gcttgaccag     1620

tggaacctga tgagacagcc cagaccagac agcgaggagt tcaaatcaat tgaggacaag     1680

ctaggtatca actttaagat tgagaggtcc attgatgata tcaggggcaa gctgagacag     1740

cttgtcctcc ttgcacaacc agggtacctg agtggggggg ttgaaccaga acaatccagc     1800

ccaactgttg agcttgacct actagggtgg tcagctacat acagcaaaga tctcgggatc     1860

tatgtgccgg tgcttgacaa ggaacgccta ttttgttctg ctgcgtatcc caagggagta     1920

gagaacaaga gtctcaaatc caaagtcggg atcgagcagg catacaaggt agtcaggtat     1980

gaggcgttga ggttggtagg tggttggaac tacccactcc tgaacaaagc ctgcaagaat     2040

aacgcaggcg ccgctcggcg gcatctggag gccaaggggt tcccactcga cgagttccta     2100

gccgagtggt ctgagctgtc agagttcggt gaggccttcg aaggcttcaa tatcaagctg     2160

accgtaacat ctgagagcct agccgaactg aacaagccag taccccccaa gcccccaaat     2220

gtcaacagac cagtcaacac tgggggactc aaggcagtca gcaacgccct caagaccggt     2280

cggtacagga acgaagccgg actgagtggt ctcgtccttc tagccacagc aagaagccgt     2340

ctgcaagatg cagttaaggc caaggcagaa gccgagaaac tccacaagtc caagccagac     2400

gaccccgatg cagactggtt cgaaagatca gaaactctgt cagaccttct ggagaaagcc     2460

gacatcgcca gcaaggtcgc ccactcagca ctcgtggaaa caagcgacgc tcttgaagca     2520

gttcagtcga cttccgtgta cacccccaag tacccagaag tcaagaaccc acagaccgcc     2580

tccaaccccg ttgttgggct ccacctgccc gccaagagag ccaccggtgt ccaggccgct     2640

cttctcggag caggaacgag cagaccaatg gggatggagg ccccaacacg gtccaagaac     2700

gccgtgaaaa tggccaaacg gcggcaacgc caaaaggaga gccgctaaca gccatgatgg     2760

gaaccactca agaagaggac actaatccca gaccccgtat ccccggcctt cgcctgcggg     2820

ggccccc                                                               2827


<210>  3
<211>  20
<212>  DNA
<213>  IBDV_f primer

<400>  3
tcactacaca ctgcagagca                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  IBDV_r primer

<400>  4
gagactccga ctcactagcc                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  IBDV_p

<400>  5
tgcccagaac ctaccggcca                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  IFN-beta_f primer

<400>  6
gacgccgcat tgaccatcta                                                   20


<210>  7
<211>  22
<212>  DNA
<213>  IFN-beta_r primer

<400>  7
ccttaggatt tccactctga ct                                                22


<210>  8
<211>  21
<212>  DNA
<213>  IFN-lambda_f primer

<400>  8
tgagctggcc ctgacgctga a                                                 21


<210>  9
<211>  19
<212>  DNA
<213>  IFN-lambda_r primer

<400>  9
aggcggaggt tgaaggtga                                                    19


<210>  10
<211>  28
<212>  DNA
<213>  IFN-gamma_f primer

<400>  10
gaaaagctga ctaattattc ggtaactg                                          28


<210>  11
<211>  22
<212>  DNA
<213>  IFN-gamma_r primer

<400>  11
gttcagccat cacttggatg ag                                                22


<210>  12
<211>  21
<212>  DNA
<213>  ISG56_f primer

<400>  12
cctggagtac tatgagcggg c                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  IFG56_r primer

<400>  13
tgggtgccta aggaccttgt c                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  MxA_f primer

<400>  14
aggtcagtta ccaggactac                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  MxA_r primer

<400>  15
atggcattct gggctttatt                                                   20


<210>  16
<211>  23
<212>  DNA
<213>  GAPDH_f primer

<400>  16
ggtatcgtgg aaggactcat gac                                               23


<210>  17
<211>  23
<212>  DNA
<213>  GAPDH_r primer

<400>  17
atgccagtga gcttcccgtt cag                                               23


