                         б

<110>  㶫ҩɷ޹˾
 
<120>  һֿPD-L1弰Ӧ

<130>  OWO21301302

<150>  CN 202011541107.9

<151>  2020-12-23

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  290
<212>  PRT
<213>  ˹

<400>  1

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  2
<211>  290
<212>  PRT
<213>  ˹

<400>  2

Met Arg Ile Phe Ala Val Phe Ile Phe Thr Ile Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Thr Ser Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Asn 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Arg Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Leu Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Ile Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala Leu Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Phe Leu Leu Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Tyr Leu Arg Lys Gly Arg Met Met Asp Met Lys Lys Cys 
            260                 265                 270         


Gly Ile Arg Val Thr Asn Ser Lys Lys Gln Arg Asp Thr Gln Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  3
<211>  342
<212>  DNA
<213>  ˹

<400>  3
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaaaatg       60

tcctgcaagg cttctggata cacattcact gactatgtta tgcactgggt gaagcaaaaa      120

cctgggcagg gccttgagtg gattggatat attaatcctt acaatgatgg tactaagttc      180

aatgaaaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctac      240

atggagctca gcagcctgac ctctgaggac tctgcggtct attactgtgc aaaacaaact      300

ctggactact ggggtcaagg aacctcagtc accgtctcct ca                         342


<210>  4
<211>  336
<212>  DNA
<213>  ˹

<400>  4
gacattgtgc tcacccaatc tccagcttct ttggctgtgt ctctagggca gagagccacc       60

atctcctgca gagccagtga aagtgttgaa tattttggca caactttaat gcagtggtac      120

caacagagac caggacagcc acccaaactc ctcatctatg ctgcatccaa cgtagaatct      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaggaa ggttccgtac      300

acgttcggag gggggaccaa gctggaaata aaacgg                                336


<210>  5
<211>  114
<212>  PRT
<213>  ˹

<400>  5

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Thr Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  6
<211>  112
<212>  PRT
<213>  ˹

<400>  6

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Phe 
            20                  25                  30          


Gly Thr Thr Leu Met Gln Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  7
<211>  342
<212>  DNA
<213>  ˹

<400>  7
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact agttatgtta tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat attaatcctc acaatgatgg taataagtac      180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag ctcagcctac      240

atggagctca gcagcctgac ctctgaggac tctgcggtct attactgtgc aaaacagact      300

atggactact ggggtcaagg aacctcagtc accgtctcct ca                         342


<210>  8
<211>  336
<212>  DNA
<213>  ˹

<400>  8
gacattgtgc tcacccaatc tccggcttct ttggctgtgt ctctagggca gagagccacc       60

ctctcctgca gagccagtga aagtgttgaa ttttatggca caactttaat gcagtggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa cgtagaatct      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaggaa ggttccgtac      300

acgttcggag gggggaccaa gctggaaata aaacgg                                336


<210>  9
<211>  114
<212>  PRT
<213>  ˹

<400>  9

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro His Asn Asp Gly Asn Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Thr Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  10
<211>  112
<212>  PRT
<213>  ˹

<400>  10

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Glu Phe Tyr 
            20                  25                  30          


Gly Thr Thr Leu Met Gln Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  11
<211>  348
<212>  DNA
<213>  ˹

<400>  11
cagcttcagg agtcaggacc tagcctcgtg aaaccttctc aaactctgtc cctcacctgt       60

tctgtcactg gcgactccat caccagtgat tactggaact ggatccggaa attcccaggg      120

aataaacttg agtacatggg atacataagc tacactggta gcacttacta caatccatct      180

ctcaaaagtc gaatctccat cactcgagac acatccaaga accagtacta cctgcagttg      240

aattctgtga ctactgagga cacagccaca tattactgtg caaagcaggg gggatggtta      300

aatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctca                   348


<210>  12
<211>  342
<212>  DNA
<213>  ˹

<400>  12
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

gtgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa ctccttggcc      120

tggtaccagc agaaaccagg acagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatggctat      300

ccgtacacgt tcggaggggg gaccaagctg gaaataaaac gg                         342


<210>  13
<211>  116
<212>  PRT
<213>  ˹

<400>  13

Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Thr Leu 
1               5                   10                  15      


Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Asp Tyr Trp 
            20                  25                  30          


Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met Gly Tyr 
        35                  40                  45              


Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg 
    50                  55                  60                  


Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu Gln Leu 
65                  70                  75                  80  


Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Lys Gln 
                85                  90                  95      


Gly Gly Trp Leu Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  14
<211>  114
<212>  PRT
<213>  ˹

<400>  14

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Val Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Gly Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  15
<211>  357
<212>  DNA
<213>  ˹

<400>  15
gaggtgcagc ttcaggagtc aggacctagc ctcgtgaaac cttctcagac tctgtccctc       60

acctgttctg tcactggcga ctccatcacc agtggttact ggaactggat ccggaaattc      120

ccagggaata aacttgagta catggggtac ataagctaca ctggtagcac ttaccagaat      180

ccatctctca aaagtcgaat ctccttcact cgagacacat ccaagaacca gtactacctg      240

cagttgagtt ctgtgactac tgaggacaca gccacatatt actgtgcaag atcccgggca      300

tggatacgga cctactttga ctactggggc cagggcacca ctctcacagt ctcctca         357


<210>  16
<211>  327
<212>  DNA
<213>  ˹

<400>  16
gaaattgtgc tcacccagtc tccagcactc atggctgcat ctccagggga gaaggtcacc       60

atcacctgca gtgtcagctc aagtataagt tccagcaact tgcactggta ccagcagaag      120

tcagaaacct cccccaaacc ctggatttat ggcacatcca acctggcttc tggagtccct      180

gttcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgtcaa cagtggagta gttacccact cacgttcggt      300

gctgggacca agctggagct gaaacgg                                          327


<210>  17
<211>  119
<212>  PRT
<213>  ˹

<400>  17

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Gln Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Phe Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Arg Ala Trp Ile Arg Thr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  18
<211>  109
<212>  PRT
<213>  ˹

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105                 


<210>  19
<211>  10
<212>  PRT
<213>  ˹

<400>  19

Gly Tyr Thr Phe Thr Asp Tyr Val Met His 
1               5                   10  


<210>  20
<211>  17
<212>  PRT
<213>  ˹

<400>  20

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  5
<212>  PRT
<213>  ˹

<400>  21

Gln Thr Leu Asp Tyr 
1               5   


<210>  22
<211>  15
<212>  PRT
<213>  ˹

<400>  22

Arg Ala Ser Glu Ser Val Glu Tyr Phe Gly Thr Thr Leu Met Gln 
1               5                   10                  15  


<210>  23
<211>  7
<212>  PRT
<213>  ˹

<400>  23

Ala Ala Ser Asn Val Glu Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  ˹

<400>  24

Gln Gln Ser Arg Lys Val Pro Tyr Thr 
1               5                   


<210>  25
<211>  10
<212>  PRT
<213>  ˹

<400>  25

Gly Tyr Thr Phe Thr Ser Tyr Val Met His 
1               5                   10  


<210>  26
<211>  17
<212>  PRT
<213>  ˹

<400>  26

Tyr Ile Asn Pro His Asn Asp Gly Asn Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  5
<212>  PRT
<213>  ˹

<400>  27

Gln Thr Met Asp Tyr 
1               5   


<210>  28
<211>  15
<212>  PRT
<213>  ˹

<400>  28

Arg Ala Ser Glu Ser Val Glu Phe Tyr Gly Thr Thr Leu Met Gln 
1               5                   10                  15  


<210>  29
<211>  7
<212>  PRT
<213>  ˹

<400>  29

Ala Ala Ser Asn Val Glu Ser 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  ˹

<400>  30

Gln Gln Ser Arg Lys Val Pro Tyr Thr 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  ˹

<400>  31

Gly Asp Ser Ile Thr Ser Asp Tyr Trp 
1               5                   


<210>  32
<211>  16
<212>  PRT
<213>  ˹

<400>  32

Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  33
<211>  10
<212>  PRT
<213>  ˹

<400>  33

Gln Gly Gly Trp Leu Asn Ala Met Asp Tyr 
1               5                   10  


<210>  34
<211>  17
<212>  PRT
<213>  ˹

<400>  34

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  35
<211>  7
<212>  PRT
<213>  ˹

<400>  35

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  ˹

<400>  36

Gln Gln Tyr Tyr Gly Tyr Pro Tyr Thr 
1               5                   


<210>  37
<211>  10
<212>  PRT
<213>  ˹

<400>  37

Gly Asp Ser Ile Thr Ser Gly Tyr Trp Asn 
1               5                   10  


<210>  38
<211>  16
<212>  PRT
<213>  ˹

<400>  38

Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Gln Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  39
<211>  11
<212>  PRT
<213>  ˹

<400>  39

Ser Arg Ala Trp Ile Arg Thr Tyr Phe Asp Tyr 
1               5                   10      


<210>  40
<211>  12
<212>  PRT
<213>  ˹

<400>  40

Ser Val Ser Ser Ser Ile Ser Ser Ser Asn Leu His 
1               5                   10          


<210>  41
<211>  7
<212>  PRT
<213>  ˹

<400>  41

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  ˹

<400>  42

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


