                         SEQUENCE LISTING

<110>  NOVARTIS AG
 
<120>  PHARMACEUTICAL COMBINATIONS COMPRISING A KRAS G12C INHIBITOR AND 
       USES OF A KRAS G12C INHIBITOR FOR THE TREATMENT OF CANCERS

<130>  PAT059013-WO-PCT04

<160>  563   

<170>  PatentIn version 3.5

<210>  1

<400>  1
000

<210>  2

<400>  2
000

<210>  3

<400>  3
000

<210>  4

<400>  4
000

<210>  5

<400>  5
000

<210>  6

<400>  6
000

<210>  7

<400>  7
000

<210>  8

<400>  8
000

<210>  9

<400>  9
000

<210>  10

<400>  10
000

<210>  11

<400>  11
000

<210>  12

<400>  12
000

<210>  13

<400>  13
000

<210>  14

<400>  14
000

<210>  15

<400>  15
000

<210>  16

<400>  16
000

<210>  17

<400>  17
000

<210>  18

<400>  18
000

<210>  19

<400>  19
000

<210>  20

<400>  20
000

<210>  21

<400>  21
000

<210>  22

<400>  22
000

<210>  23

<400>  23
000

<210>  24

<400>  24
000

<210>  25

<400>  25
000

<210>  26

<400>  26
000

<210>  27

<400>  27
000

<210>  28

<400>  28
000

<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33

<400>  33
000

<210>  34

<400>  34
000

<210>  35

<400>  35
000

<210>  36

<400>  36
000

<210>  37

<400>  37
000

<210>  38

<400>  38
000

<210>  39

<400>  39
000

<210>  40

<400>  40
000

<210>  41

<400>  41
000

<210>  42

<400>  42
000

<210>  43

<400>  43
000

<210>  44

<400>  44
000

<210>  45

<400>  45
000

<210>  46

<400>  46
000

<210>  47

<400>  47
000

<210>  48

<400>  48
000

<210>  49

<400>  49
000

<210>  50

<400>  50
000

<210>  51

<400>  51
000

<210>  52

<400>  52
000

<210>  53

<400>  53
000

<210>  54

<400>  54
000

<210>  55

<400>  55
000

<210>  56

<400>  56
000

<210>  57

<400>  57
000

<210>  58

<400>  58
000

<210>  59

<400>  59
000

<210>  60

<400>  60
000

<210>  61

<400>  61
000

<210>  62

<400>  62
000

<210>  63

<400>  63
000

<210>  64

<400>  64
000

<210>  65

<400>  65
000

<210>  66

<400>  66
000

<210>  67

<400>  67
000

<210>  68

<400>  68
000

<210>  69

<400>  69
000

<210>  70

<400>  70
000

<210>  71

<400>  71
000

<210>  72

<400>  72
000

<210>  73

<400>  73
000

<210>  74

<400>  74
000

<210>  75

<400>  75
000

<210>  76

<400>  76
000

<210>  77

<400>  77
000

<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81

<400>  81
000

<210>  82

<400>  82
000

<210>  83

<400>  83
000

<210>  84

<400>  84
000

<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101

<400>  101
000

<210>  102

<400>  102
000

<210>  103

<400>  103
000

<210>  104

<400>  104
000

<210>  105

<400>  105
000

<210>  106

<400>  106
000

<210>  107

<400>  107
000

<210>  108

<400>  108
000

<210>  109

<400>  109
000

<210>  110

<400>  110
000

<210>  111

<400>  111
000

<210>  112

<400>  112
000

<210>  113

<400>  113
000

<210>  114

<400>  114
000

<210>  115

<400>  115
000

<210>  116

<400>  116
000

<210>  117

<400>  117
000

<210>  118

<400>  118
000

<210>  119

<400>  119
000

<210>  120

<400>  120
000

<210>  121

<400>  121
000

<210>  122

<400>  122
000

<210>  123

<400>  123
000

<210>  124

<400>  124
000

<210>  125

<400>  125
000

<210>  126

<400>  126
000

<210>  127

<400>  127
000

<210>  128

<400>  128
000

<210>  129

<400>  129
000

<210>  130

<400>  130
000

<210>  131

<400>  131
000

<210>  132

<400>  132
000

<210>  133

<400>  133
000

<210>  134

<400>  134
000

<210>  135

<400>  135
000

<210>  136

<400>  136
000

<210>  137

<400>  137
000

<210>  138

<400>  138
000

<210>  139

<400>  139
000

<210>  140

<400>  140
000

<210>  141

<400>  141
000

<210>  142

<400>  142
000

<210>  143

<400>  143
000

<210>  144

<400>  144
000

<210>  145

<400>  145
000

<210>  146

<400>  146
000

<210>  147

<400>  147
000

<210>  148

<400>  148
000

<210>  149

<400>  149
000

<210>  150

<400>  150
000

<210>  151

<400>  151
000

<210>  152

<400>  152
000

<210>  153

<400>  153
000

<210>  154

<400>  154
000

<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169

<400>  169
000

<210>  170

<400>  170
000

<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173

<400>  173
000

<210>  174

<400>  174
000

<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179

<400>  179
000

<210>  180

<400>  180
000

<210>  181

<400>  181
000

<210>  182

<400>  182
000

<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190

<400>  190
000

<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194

<400>  194
000

<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200

<400>  200
000

<210>  201

<400>  201
000

<210>  202

<400>  202
000

<210>  203

<400>  203
000

<210>  204

<400>  204
000

<210>  205

<400>  205
000

<210>  206

<400>  206
000

<210>  207

<400>  207
000

<210>  208

<400>  208
000

<210>  209

<400>  209
000

<210>  210

<400>  210
000

<210>  211

<400>  211
000

<210>  212

<400>  212
000

<210>  213

<400>  213
000

<210>  214

<400>  214
000

<210>  215

<400>  215
000

<210>  216

<400>  216
000

<210>  217

<400>  217
000

<210>  218

<400>  218
000

<210>  219

<400>  219
000

<210>  220

<400>  220
000

<210>  221

<400>  221
000

<210>  222

<400>  222
000

<210>  223

<400>  223
000

<210>  224

<400>  224
000

<210>  225

<400>  225
000

<210>  226

<400>  226
000

<210>  227

<400>  227
000

<210>  228

<400>  228
000

<210>  229

<400>  229
000

<210>  230

<400>  230
000

<210>  231

<400>  231
000

<210>  232

<400>  232
000

<210>  233

<400>  233
000

<210>  234

<400>  234
000

<210>  235

<400>  235
000

<210>  236

<400>  236
000

<210>  237

<400>  237
000

<210>  238

<400>  238
000

<210>  239

<400>  239
000

<210>  240

<400>  240
000

<210>  241

<400>  241
000

<210>  242

<400>  242
000

<210>  243

<400>  243
000

<210>  244

<400>  244
000

<210>  245

<400>  245
000

<210>  246

<400>  246
000

<210>  247

<400>  247
000

<210>  248

<400>  248
000

<210>  249

<400>  249
000

<210>  250

<400>  250
000

<210>  251

<400>  251
000

<210>  252

<400>  252
000

<210>  253

<400>  253
000

<210>  254

<400>  254
000

<210>  255

<400>  255
000

<210>  256

<400>  256
000

<210>  257

<400>  257
000

<210>  258

<400>  258
000

<210>  259

<400>  259
000

<210>  260

<400>  260
000

<210>  261

<400>  261
000

<210>  262

<400>  262
000

<210>  263

<400>  263
000

<210>  264

<400>  264
000

<210>  265

<400>  265
000

<210>  266

<400>  266
000

<210>  267

<400>  267
000

<210>  268

<400>  268
000

<210>  269

<400>  269
000

<210>  270

<400>  270
000

<210>  271

<400>  271
000

<210>  272

<400>  272
000

<210>  273

<400>  273
000

<210>  274

<400>  274
000

<210>  275

<400>  275
000

<210>  276

<400>  276
000

<210>  277

<400>  277
000

<210>  278

<400>  278
000

<210>  279

<400>  279
000

<210>  280

<400>  280
000

<210>  281

<400>  281
000

<210>  282

<400>  282
000

<210>  283

<400>  283
000

<210>  284

<400>  284
000

<210>  285

<400>  285
000

<210>  286

<400>  286
000

<210>  287

<400>  287
000

<210>  288

<400>  288
000

<210>  289

<400>  289
000

<210>  290

<400>  290
000

<210>  291

<400>  291
000

<210>  292

<400>  292
000

<210>  293

<400>  293
000

<210>  294

<400>  294
000

<210>  295

<400>  295
000

<210>  296

<400>  296
000

<210>  297

<400>  297
000

<210>  298

<400>  298
000

<210>  299

<400>  299
000

<210>  300

<400>  300
000

<210>  301

<400>  301
000

<210>  302

<400>  302
000

<210>  303

<400>  303
000

<210>  304

<400>  304
000

<210>  305

<400>  305
000

<210>  306

<400>  306
000

<210>  307

<400>  307
000

<210>  308

<400>  308
000

<210>  309

<400>  309
000

<210>  310

<400>  310
000

<210>  311

<400>  311
000

<210>  312

<400>  312
000

<210>  313

<400>  313
000

<210>  314

<400>  314
000

<210>  315

<400>  315
000

<210>  316

<400>  316
000

<210>  317

<400>  317
000

<210>  318

<400>  318
000

<210>  319

<400>  319
000

<210>  320

<400>  320
000

<210>  321

<400>  321
000

<210>  322

<400>  322
000

<210>  323

<400>  323
000

<210>  324

<400>  324
000

<210>  325

<400>  325
000

<210>  326

<400>  326
000

<210>  327

<400>  327
000

<210>  328

<400>  328
000

<210>  329

<400>  329
000

<210>  330

<400>  330
000

<210>  331

<400>  331
000

<210>  332

<400>  332
000

<210>  333

<400>  333
000

<210>  334

<400>  334
000

<210>  335

<400>  335
000

<210>  336

<400>  336
000

<210>  337

<400>  337
000

<210>  338

<400>  338
000

<210>  339

<400>  339
000

<210>  340

<400>  340
000

<210>  341

<400>  341
000

<210>  342

<400>  342
000

<210>  343

<400>  343
000

<210>  344

<400>  344
000

<210>  345

<400>  345
000

<210>  346

<400>  346
000

<210>  347

<400>  347
000

<210>  348

<400>  348
000

<210>  349

<400>  349
000

<210>  350

<400>  350
000

<210>  351

<400>  351
000

<210>  352

<400>  352
000

<210>  353

<400>  353
000

<210>  354

<400>  354
000

<210>  355

<400>  355
000

<210>  356

<400>  356
000

<210>  357

<400>  357
000

<210>  358

<400>  358
000

<210>  359

<400>  359
000

<210>  360

<400>  360
000

<210>  361

<400>  361
000

<210>  362

<400>  362
000

<210>  363

<400>  363
000

<210>  364

<400>  364
000

<210>  365

<400>  365
000

<210>  366

<400>  366
000

<210>  367

<400>  367
000

<210>  368

<400>  368
000

<210>  369

<400>  369
000

<210>  370

<400>  370
000

<210>  371

<400>  371
000

<210>  372

<400>  372
000

<210>  373

<400>  373
000

<210>  374

<400>  374
000

<210>  375

<400>  375
000

<210>  376

<400>  376
000

<210>  377

<400>  377
000

<210>  378

<400>  378
000

<210>  379

<400>  379
000

<210>  380

<400>  380
000

<210>  381

<400>  381
000

<210>  382

<400>  382
000

<210>  383

<400>  383
000

<210>  384

<400>  384
000

<210>  385

<400>  385
000

<210>  386

<400>  386
000

<210>  387

<400>  387
000

<210>  388

<400>  388
000

<210>  389

<400>  389
000

<210>  390

<400>  390
000

<210>  391

<400>  391
000

<210>  392

<400>  392
000

<210>  393

<400>  393
000

<210>  394

<400>  394
000

<210>  395

<400>  395
000

<210>  396

<400>  396
000

<210>  397

<400>  397
000

<210>  398

<400>  398
000

<210>  399

<400>  399
000

<210>  400

<400>  400
000

<210>  401

<400>  401
000

<210>  402

<400>  402
000

<210>  403

<400>  403
000

<210>  404

<400>  404
000

<210>  405

<400>  405
000

<210>  406

<400>  406
000

<210>  407

<400>  407
000

<210>  408

<400>  408
000

<210>  409

<400>  409
000

<210>  410

<400>  410
000

<210>  411

<400>  411
000

<210>  412

<400>  412
000

<210>  413

<400>  413
000

<210>  414

<400>  414
000

<210>  415

<400>  415
000

<210>  416

<400>  416
000

<210>  417

<400>  417
000

<210>  418

<400>  418
000

<210>  419

<400>  419
000

<210>  420

<400>  420
000

<210>  421

<400>  421
000

<210>  422

<400>  422
000

<210>  423

<400>  423
000

<210>  424

<400>  424
000

<210>  425

<400>  425
000

<210>  426

<400>  426
000

<210>  427

<400>  427
000

<210>  428

<400>  428
000

<210>  429

<400>  429
000

<210>  430

<400>  430
000

<210>  431

<400>  431
000

<210>  432

<400>  432
000

<210>  433

<400>  433
000

<210>  434

<400>  434
000

<210>  435

<400>  435
000

<210>  436

<400>  436
000

<210>  437

<400>  437
000

<210>  438

<400>  438
000

<210>  439

<400>  439
000

<210>  440

<400>  440
000

<210>  441

<400>  441
000

<210>  442

<400>  442
000

<210>  443

<400>  443
000

<210>  444

<400>  444
000

<210>  445

<400>  445
000

<210>  446

<400>  446
000

<210>  447

<400>  447
000

<210>  448

<400>  448
000

<210>  449

<400>  449
000

<210>  450

<400>  450
000

<210>  451

<400>  451
000

<210>  452

<400>  452
000

<210>  453

<400>  453
000

<210>  454

<400>  454
000

<210>  455

<400>  455
000

<210>  456

<400>  456
000

<210>  457

<400>  457
000

<210>  458

<400>  458
000

<210>  459

<400>  459
000

<210>  460

<400>  460
000

<210>  461

<400>  461
000

<210>  462

<400>  462
000

<210>  463

<400>  463
000

<210>  464

<400>  464
000

<210>  465

<400>  465
000

<210>  466

<400>  466
000

<210>  467

<400>  467
000

<210>  468

<400>  468
000

<210>  469

<400>  469
000

<210>  470

<400>  470
000

<210>  471

<400>  471
000

<210>  472

<400>  472
000

<210>  473

<400>  473
000

<210>  474

<400>  474
000

<210>  475

<400>  475
000

<210>  476

<400>  476
000

<210>  477

<400>  477
000

<210>  478

<400>  478
000

<210>  479

<400>  479
000

<210>  480

<400>  480
000

<210>  481

<400>  481
000

<210>  482

<400>  482
000

<210>  483

<400>  483
000

<210>  484

<400>  484
000

<210>  485

<400>  485
000

<210>  486

<400>  486
000

<210>  487

<400>  487
000

<210>  488

<400>  488
000

<210>  489

<400>  489
000

<210>  490

<400>  490
000

<210>  491

<400>  491
000

<210>  492

<400>  492
000

<210>  493

<400>  493
000

<210>  494

<400>  494
000

<210>  495

<400>  495
000

<210>  496

<400>  496
000

<210>  497

<400>  497
000

<210>  498

<400>  498
000

<210>  499

<400>  499
000

<210>  500

<400>  500
000

<210>  501
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  501

Thr Tyr Trp Met His 
1               5   


<210>  502
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  502

Asn Ile Tyr Pro Gly Thr Gly Gly Ser Asn Phe Asp Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  503
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  503

Trp Thr Thr Gly Thr Gly Ala Tyr 
1               5               


<210>  504
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  504

Gly Tyr Thr Phe Thr Thr Tyr 
1               5           


<210>  505
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  505

Tyr Pro Gly Thr Gly Gly 
1               5       


<210>  506
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  506

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Thr Gly Gly Ser Asn Phe Asp Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Thr Thr Gly Thr Gly Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  507
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  507
gaggtgcagc tggtgcagtc aggcgccgaa gtgaagaagc ccggcgagtc actgagaatt       60

agctgtaaag gttcaggcta caccttcact acctactgga tgcactgggt ccgccaggct      120

accggtcaag gcctcgagtg gatgggtaat atctaccccg gcaccggcgg ctctaacttc      180

gacgagaagt ttaagaatag agtgactatc accgccgata agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcac taggtggact      300

accggcacag gcgcctactg gggtcaaggc actaccgtga ccgtgtctag c               351


<210>  508
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  508

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Thr Gly Gly Ser Asn Phe Asp Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Thr Thr Gly Thr Gly Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440             


<210>  509
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  509
gaggtgcagc tggtgcagtc aggcgccgaa gtgaagaagc ccggcgagtc actgagaatt       60

agctgtaaag gttcaggcta caccttcact acctactgga tgcactgggt ccgccaggct      120

accggtcaag gcctcgagtg gatgggtaat atctaccccg gcaccggcgg ctctaacttc      180

gacgagaagt ttaagaatag agtgactatc accgccgata agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcac taggtggact      300

accggcacag gcgcctactg gggtcaaggc actaccgtga ccgtgtctag cgctagcact      360

aagggcccgt ccgtgttccc cctggcacct tgtagccgga gcactagcga atccaccgct      420

gccctcggct gcctggtcaa ggattacttc ccggagcccg tgaccgtgtc ctggaacagc      480

ggagccctga cctccggagt gcacaccttc cccgctgtgc tgcagagctc cgggctgtac      540

tcgctgtcgt cggtggtcac ggtgccttca tctagcctgg gtaccaagac ctacacttgc      600

aacgtggacc acaagccttc caacactaag gtggacaagc gcgtcgaatc gaagtacggc      660

ccaccgtgcc cgccttgtcc cgcgccggag ttcctcggcg gtccctcggt ctttctgttc      720

ccaccgaagc ccaaggacac tttgatgatt tcccgcaccc ctgaagtgac atgcgtggtc      780

gtggacgtgt cacaggaaga tccggaggtg cagttcaatt ggtacgtgga tggcgtcgag      840

gtgcacaacg ccaaaaccaa gccgagggag gagcagttca actccactta ccgcgtcgtg      900

tccgtgctga cggtgctgca tcaggactgg ctgaacggga aggagtacaa gtgcaaagtg      960

tccaacaagg gacttcctag ctcaatcgaa aagaccatct cgaaagccaa gggacagccc     1020

cgggaacccc aagtgtatac cctgccaccg agccaggaag aaatgactaa gaaccaagtc     1080

tcattgactt gccttgtgaa gggcttctac ccatcggata tcgccgtgga atgggagtcc     1140

aacggccagc cggaaaacaa ctacaagacc acccctccgg tgctggactc agacggatcc     1200

ttcttcctct actcgcggct gaccgtggat aagagcagat ggcaggaggg aaatgtgttc     1260

agctgttctg tgatgcatga agccctgcac aaccactaca ctcagaagtc cctgtccctc     1320

tccctggga                                                             1329


<210>  510
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  510

Lys Ser Ser Gln Ser Leu Leu Asp Ser Gly Asn Gln Lys Asn Phe Leu 
1               5                   10                  15      


Thr 
    


<210>  511
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  511

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  512
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  512

Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  513
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  513

Ser Gln Ser Leu Leu Asp Ser Gly Asn Gln Lys Asn Phe 
1               5                   10              


<210>  514
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  514

Trp Ala Ser 
1           


<210>  515
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  515

Asp Tyr Ser Tyr Pro Tyr 
1               5       


<210>  516
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  516

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  517
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  517
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg taaagcccct aagctgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tgcagcccga ggatatcgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaag                             339


<210>  518
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  518

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  519
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  519
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg taaagcccct aagctgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tgcagcccga ggatatcgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaagc gtacggtggc cgctcccagc      360

gtgttcatct tcccccccag cgacgagcag ctgaagagcg gcaccgccag cgtggtgtgc      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caacgccctg      480

cagagcggca acagccagga gagcgtcacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcataaggt gtacgcctgc      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaacag gggcgagtgc      660


<210>  520
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  520

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  521
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  521
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg tcaagcccct agactgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tggaagccga ggacgccgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaag                             339


<210>  522
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  522

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  523
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  523
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg tcaagcccct agactgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tggaagccga ggacgccgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaagc gtacggtggc cgctcccagc      360

gtgttcatct tcccccccag cgacgagcag ctgaagagcg gcaccgccag cgtggtgtgc      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caacgccctg      480

cagagcggca acagccagga gagcgtcacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcataaggt gtacgcctgc      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaacag gggcgagtgc      660


<210>  524
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  524
acctactgga tgcac                                                        15


<210>  525
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  525
aatatctacc ccggcaccgg cggctctaac ttcgacgaga agtttaagaa t                51


<210>  526
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  526
tggactaccg gcacaggcgc ctac                                              24


<210>  527
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  527
ggctacacct tcactaccta c                                                 21


<210>  528
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  528
taccccggca ccggcggc                                                     18


<210>  529
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  529
aaatctagtc agtcactgct ggatagcggt aatcagaaga acttcctgac c                51


<210>  530
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  530
tgggcctcta ctagagaatc a                                                 21


<210>  531
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  531
cagaacgact atagctaccc ctacacc                                           27


<210>  532
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  532
agtcagtcac tgctggatag cggtaatcag aagaacttc                              39


<210>  533
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  533
tgggcctct                                                                9


<210>  534
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  534
gactatagct acccctac                                                     18


<210>  535

<400>  535
000

<210>  536

<400>  536
000

<210>  537

<400>  537
000

<210>  538

<400>  538
000

<210>  539

<400>  539
000

<210>  540

<400>  540
000

<210>  541

<400>  541
000

<210>  542
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  542

Lys Ser Ser Glu Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  543
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  543

Tyr Ala Phe His Arg Phe Thr 
1               5           


<210>  544
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  544

His Gln Ala Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  545
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  545

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  546
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  546

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  547
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  547

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  548
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  548

Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  549
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  549

Ala Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10          


<210>  550
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  550

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  551
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  551

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Ala Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  552
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  552
gtcatttgaa gatatccacc gttatcgcga gcagattaag a                           41


<210>  553
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  553
tcttaatctg ctcgcgataa cggtggatat cttcaaatga c                           41


<210>  554
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  554
tcatttgaag atatccacca gtatcgcgag cagattaaga g                           41


<210>  555
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  555
ctcttaatct gctcgcgata ctggtggata tcttcaaatg a                           41


<210>  556
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  556
agtcatttga agatatccac gattatcgcg agcagattaa g                           41


<210>  557
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  557
cttaatctgc tcgcgataat cgtggatatc ttcaaatgac t                           41


<210>  558
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  558
gaagagtact ccgcaatgag cgatcaatac atgaggacg                              39


<210>  559
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  559
cgtcctcatg tattgatcgc tcattgcgga gtactcttc                              39


<210>  560
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  560
cgaagtcatt tgaagatatc caccattgtc gcgagcagat ta                          42


<210>  561
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  561
taatctgctc gcgacaatgg tggatatctt caaatgactt cg                          42


<210>  562
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  562
cgaagtcatt tgaagatatc caccatgatc gcgagcagat t                           41


<210>  563
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  563
aatctgctcg cgatcatggt ggatatcttc aaatgacttc g                           41


