                         SEQUENCE LISTING

<110>  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
       KIRA PHARMACEUTICALS (SUZHOU) LTD.
       Song, Wenchao
       Miwa, Takashi
       Sato, Sayaka
       Gullipalli, Damodara Rao
       Tsiu, Ping
       Zhu, Xihua
       Zhao, Jianjun
       Xu, Yingying
 
<120>  HUMANIZED ANTI-C5 ANTIBODIES AND FACTOR H FUSION PROTEINS AND 
       USES THEREOF

<130>  046483-6179-00WO

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-C5 mAb VH no mutation

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Glu Tyr Thr Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Phe Gly Ser Ser Pro Asn Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-C5 mAb VL no mutation

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR1 containing Y32H

<400>  3

Ala Ser Gly Tyr Ile Phe Ser Asn His Trp Ile Gln 
1               5                   10          


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR2 of anti-C5 mAb VH no mutation

<400>  4

Glu Ile Leu Pro Gly Ser Gly Ser Thr Glu 
1               5                   10  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR3 of anti-C5 mAb VH no mutation

<400>  5

Ala Arg Tyr Phe Phe Gly Ser Ser Pro Asn Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR1 of anti-C5 mAb VL no mutation

<400>  6

Gly Ala Ser Glu Asn Ile Tyr Gly Ala Leu Asn 
1               5                   10      


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR2 of anti-C5 mAb VL no mutation

<400>  7

Tyr Gly Ala Thr Asn Leu Ala Asp 
1               5               


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR3 of anti-C5 mAb VL no mutation

<400>  8

Gln Asn Val Leu Asn Thr Pro Leu Thr 
1               5                   


<210>  9
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of Y32H mutant

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asn His 
            20                  25                  30          


Trp Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Glu Tyr Thr Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Phe Gly Ser Ser Pro Asn Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  1336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of Y32H-IgG4PLA-fH1-5

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asn His 
            20                  25                  30          


Trp Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Glu Tyr Thr Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Phe Gly Ser Ser Pro Asn Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu 
            420                 425                 430         


Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


Lys Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu 
    450                 455                 460                 


Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile 
465                 470                 475                 480 


Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val 
                485                 490                 495     


Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln 
            500                 505                 510         


Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr 
        515                 520                 525             


Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr 
    530                 535                 540                 


Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys 
545                 550                 555                 560 


Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys 
                565                 570                 575     


Cys Leu Pro Val Thr Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            580                 585                 590         


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        595                 600                 605             


Ile Phe Ser Asn His Trp Ile Gln Trp Val Arg Gln Ala Pro Gly Gln 
    610                 615                 620                 


Gly Leu Glu Trp Met Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Glu 
625                 630                 635                 640 


Tyr Thr Glu Asn Phe Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser 
                645                 650                 655     


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            660                 665                 670         


Ala Val Tyr Tyr Cys Ala Arg Tyr Phe Phe Gly Ser Ser Pro Asn Trp 
        675                 680                 685             


Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    690                 695                 700                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
705                 710                 715                 720 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                725                 730                 735     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            740                 745                 750         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        755                 760                 765             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
    770                 775                 780                 


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
785                 790                 795                 800 


Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
                805                 810                 815     


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            820                 825                 830         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        835                 840                 845             


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    850                 855                 860                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
865                 870                 875                 880 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                885                 890                 895     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            900                 905                 910         


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        915                 920                 925             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
    930                 935                 940                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
945                 950                 955                 960 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                965                 970                 975     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
            980                 985                 990         


Leu Thr Val Asp Lys Ser Arg Trp  Gln Glu Gly Asn Val  Phe Ser Cys 
        995                 1000                 1005             


Ser Val  Leu His Glu Ala Leu  His Ala His Tyr Thr  Gln Lys Ser 
    1010                 1015                 1020             


Leu Ser  Leu Ser Leu Gly Lys  Glu Asp Cys Asn Glu  Leu Pro Pro 
    1025                 1030                 1035             


Arg Arg  Asn Thr Glu Ile Leu  Thr Gly Ser Trp Ser  Asp Gln Thr 
    1040                 1045                 1050             


Tyr Pro  Glu Gly Thr Gln Ala  Ile Tyr Lys Cys Arg  Pro Gly Tyr 
    1055                 1060                 1065             


Arg Ser  Leu Gly Asn Ile Ile  Met Val Cys Arg Lys  Gly Glu Trp 
    1070                 1075                 1080             


Val Ala  Leu Asn Pro Leu Arg  Lys Cys Gln Lys Arg  Pro Cys Gly 
    1085                 1090                 1095             


His Pro  Gly Asp Thr Pro Phe  Gly Thr Phe Thr Leu  Thr Gly Gly 
    1100                 1105                 1110             


Asn Val  Phe Glu Tyr Gly Val  Lys Ala Val Tyr Thr  Cys Asn Glu 
    1115                 1120                 1125             


Gly Tyr  Gln Leu Leu Gly Glu  Ile Asn Tyr Arg Glu  Cys Asp Thr 
    1130                 1135                 1140             


Asp Gly  Trp Thr Asn Asp Ile  Pro Ile Cys Glu Val  Val Lys Cys 
    1145                 1150                 1155             


Leu Pro  Val Thr Ala Pro Glu  Asn Gly Lys Ile Val  Ser Ser Ala 
    1160                 1165                 1170             


Met Glu  Pro Asp Arg Glu Tyr  His Phe Gly Gln Ala  Val Arg Phe 
    1175                 1180                 1185             


Val Cys  Asn Ser Gly Tyr Lys  Ile Glu Gly Asp Glu  Glu Met His 
    1190                 1195                 1200             


Cys Ser  Asp Asp Gly Phe Trp  Ser Lys Glu Lys Pro  Lys Cys Val 
    1205                 1210                 1215             


Glu Ile  Ser Cys Lys Ser Pro  Asp Val Ile Asn Gly  Ser Pro Ile 
    1220                 1225                 1230             


Ser Gln  Lys Ile Ile Tyr Lys  Glu Asn Glu Arg Phe  Gln Tyr Lys 
    1235                 1240                 1245             


Cys Asn  Met Gly Tyr Glu Tyr  Ser Glu Arg Gly Asp  Ala Val Cys 
    1250                 1255                 1260             


Thr Glu  Ser Gly Trp Arg Pro  Leu Pro Ser Cys Glu  Glu Lys Ser 
    1265                 1270                 1275             


Cys Asp  Asn Pro Tyr Ile Pro  Asn Gly Asp Tyr Ser  Pro Leu Arg 
    1280                 1285                 1290             


Ile Lys  His Arg Thr Gly Asp  Glu Ile Thr Tyr Gln  Cys Arg Asn 
    1295                 1300                 1305             


Gly Phe  Tyr Pro Ala Thr Arg  Gly Asn Thr Ala Lys  Cys Thr Ser 
    1310                 1315                 1320             


Thr Gly  Trp Ile Pro Ala Pro  Arg Cys Thr Leu Lys  Pro 
    1325                 1330                 1335     


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR1 containing E27H

<400>  11

Gly Ala Ser His Asn Ile Tyr Gly Ala Leu Asn 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR1 containing N28H

<400>  12

Gly Ala Ser Glu His Ile Tyr Gly Ala Leu Asn 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR1 containing Y30H

<400>  13

Gly Ala Ser Glu Asn Ile His Gly Ala Leu Asn 
1               5                   10      


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR2 containing T52H

<400>  14

Tyr Gly Ala His Asn Leu Ala Asp 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR2 containing L54H

<400>  15

Tyr Gly Ala Thr Asn His Ala Asp 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR2 containing D56H

<400>  16

Tyr Gly Ala Thr Asn Leu Ala His 
1               5               


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR3 containing T97H

<400>  17

Gln Asn Val Leu Asn Thr Pro Leu His 
1               5                   


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL, Q38R

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL, Q38R/E27H

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser His Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL, Q38R/N28H

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu His Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL, Q38R/Y30H

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile His Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  22
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL, Q38R/T52H

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala His Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  23
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL, Q38R/L54H

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn His Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  24
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL, Q38R/D56H

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala His Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL, Q38R/T97H

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


His Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  26
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT IgG4 Fc

<400>  26

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  27
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc with PLA mutations

<400>  27

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Leu His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  28
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y32H heavy chain with PLA mutation

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asn His 
            20                  25                  30          


Trp Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Glu Tyr Thr Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Phe Gly Ser Ser Pro Asn Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu 
            420                 425                 430         


Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


Lys 
    


<210>  29
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y32H heavy chain with PLA mutation factor H fusion

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asn His 
            20                  25                  30          


Trp Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Glu Tyr Thr Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Phe Gly Ser Ser Pro Asn Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu 
            420                 425                 430         


Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


Lys Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu 
    450                 455                 460                 


Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile 
465                 470                 475                 480 


Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val 
                485                 490                 495     


Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln 
            500                 505                 510         


Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr 
        515                 520                 525             


Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr 
    530                 535                 540                 


Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys 
545                 550                 555                 560 


Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys 
                565                 570                 575     


Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala 
            580                 585                 590         


Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val 
        595                 600                 605             


Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser 
    610                 615                 620                 


Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser 
625                 630                 635                 640 


Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile 
                645                 650                 655     


Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr 
            660                 665                 670         


Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg 
        675                 680                 685             


Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro 
    690                 695                 700                 


Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu 
705                 710                 715                 720 


Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn 
                725                 730                 735     


Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr 
            740                 745                 750         


Leu Lys Pro 
        755 


<210>  30
<211>  1676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5 (human)

<400>  30

Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 
1               5                   10                  15      


Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu 
        35                  40                  45              


Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 


Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 
145                 150                 155                 160 


Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln 
        275                 280                 285             


Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu 
    290                 295                 300                 


Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             


Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Thr Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met 
            580                 585                 590         


Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Val Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 
                805                 810                 815     


Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr 
        835                 840                 845             


Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly 
    850                 855                 860                 


Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser 
865                 870                 875                 880 


Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val 
                885                 890                 895     


Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe 
            900                 905                 910         


Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg 
        915                 920                 925             


Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu 
    930                 935                 940                 


Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro 
945                 950                 955                 960 


Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile 
                965                 970                 975     


Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu 
            980                 985                 990         


Ser Gln Glu Gly Ile Asn Ile Leu  Thr His Leu Pro Lys  Gly Ser Ala 
        995                 1000                 1005             


Glu Ala  Glu Leu Met Ser Val  Val Pro Val Phe Tyr  Val Phe His 
    1010                 1015                 1020             


Tyr Leu  Glu Thr Gly Asn His  Trp Asn Ile Phe His  Ser Asp Pro 
    1025                 1030                 1035             


Leu Ile  Glu Lys Gln Lys Leu  Lys Lys Lys Leu Lys  Glu Gly Met 
    1040                 1045                 1050             


Leu Ser  Ile Met Ser Tyr Arg  Asn Ala Asp Tyr Ser  Tyr Ser Val 
    1055                 1060                 1065             


Trp Lys  Gly Gly Ser Ala Ser  Thr Trp Leu Thr Ala  Phe Ala Leu 
    1070                 1075                 1080             


Arg Val  Leu Gly Gln Val Asn  Lys Tyr Val Glu Gln  Asn Gln Asn 
    1085                 1090                 1095             


Ser Ile  Cys Asn Ser Leu Leu  Trp Leu Val Glu Asn  Tyr Gln Leu 
    1100                 1105                 1110             


Asp Asn  Gly Ser Phe Lys Glu  Asn Ser Gln Tyr Gln  Pro Ile Lys 
    1115                 1120                 1125             


Leu Gln  Gly Thr Leu Pro Val  Glu Ala Arg Glu Asn  Ser Leu Tyr 
    1130                 1135                 1140             


Leu Thr  Ala Phe Thr Val Ile  Gly Ile Arg Lys Ala  Phe Asp Ile 
    1145                 1150                 1155             


Cys Pro  Leu Val Lys Ile Asp  Thr Ala Leu Ile Lys  Ala Asp Asn 
    1160                 1165                 1170             


Phe Leu  Leu Glu Asn Thr Leu  Pro Ala Gln Ser Thr  Phe Thr Leu 
    1175                 1180                 1185             


Ala Ile  Ser Ala Tyr Ala Leu  Ser Leu Gly Asp Lys  Thr His Pro 
    1190                 1195                 1200             


Gln Phe  Arg Ser Ile Val Ser  Ala Leu Lys Arg Glu  Ala Leu Val 
    1205                 1210                 1215             


Lys Gly  Asn Pro Pro Ile Tyr  Arg Phe Trp Lys Asp  Asn Leu Gln 
    1220                 1225                 1230             


His Lys  Asp Ser Ser Val Pro  Asn Thr Gly Thr Ala  Arg Met Val 
    1235                 1240                 1245             


Glu Thr  Thr Ala Tyr Ala Leu  Leu Thr Ser Leu Asn  Leu Lys Asp 
    1250                 1255                 1260             


Ile Asn  Tyr Val Asn Pro Val  Ile Lys Trp Leu Ser  Glu Glu Gln 
    1265                 1270                 1275             


Arg Tyr  Gly Gly Gly Phe Tyr  Ser Thr Gln Asp Thr  Ile Asn Ala 
    1280                 1285                 1290             


Ile Glu  Gly Leu Thr Glu Tyr  Ser Leu Leu Val Lys  Gln Leu Arg 
    1295                 1300                 1305             


Leu Ser  Met Asp Ile Asp Val  Ser Tyr Lys His Lys  Gly Ala Leu 
    1310                 1315                 1320             


His Asn  Tyr Lys Met Thr Asp  Lys Asn Phe Leu Gly  Arg Pro Val 
    1325                 1330                 1335             


Glu Val  Leu Leu Asn Asp Asp  Leu Ile Val Ser Thr  Gly Phe Gly 
    1340                 1345                 1350             


Ser Gly  Leu Ala Thr Val His  Val Thr Thr Val Val  His Lys Thr 
    1355                 1360                 1365             


Ser Thr  Ser Glu Glu Val Cys  Ser Phe Tyr Leu Lys  Ile Asp Thr 
    1370                 1375                 1380             


Gln Asp  Ile Glu Ala Ser His  Tyr Arg Gly Tyr Gly  Asn Ser Asp 
    1385                 1390                 1395             


Tyr Lys  Arg Ile Val Ala Cys  Ala Ser Tyr Lys Pro  Ser Arg Glu 
    1400                 1405                 1410             


Glu Ser  Ser Ser Gly Ser Ser  His Ala Val Met Asp  Ile Ser Leu 
    1415                 1420                 1425             


Pro Thr  Gly Ile Ser Ala Asn  Glu Glu Asp Leu Lys  Ala Leu Val 
    1430                 1435                 1440             


Glu Gly  Val Asp Gln Leu Phe  Thr Asp Tyr Gln Ile  Lys Asp Gly 
    1445                 1450                 1455             


His Val  Ile Leu Gln Leu Asn  Ser Ile Pro Ser Ser  Asp Phe Leu 
    1460                 1465                 1470             


Cys Val  Arg Phe Arg Ile Phe  Glu Leu Phe Glu Val  Gly Phe Leu 
    1475                 1480                 1485             


Ser Pro  Ala Thr Phe Thr Val  Tyr Glu Tyr His Arg  Pro Asp Lys 
    1490                 1495                 1500             


Gln Cys  Thr Met Phe Tyr Ser  Thr Ser Asn Ile Lys  Ile Gln Lys 
    1505                 1510                 1515             


Val Cys  Glu Gly Ala Ala Cys  Lys Cys Val Glu Ala  Asp Cys Gly 
    1520                 1525                 1530             


Gln Met  Gln Glu Glu Leu Asp  Leu Thr Ile Ser Ala  Glu Thr Arg 
    1535                 1540                 1545             


Lys Gln  Thr Ala Cys Lys Pro  Glu Ile Ala Tyr Ala  Tyr Lys Val 
    1550                 1555                 1560             


Ser Ile  Thr Ser Ile Thr Val  Glu Asn Val Phe Val  Lys Tyr Lys 
    1565                 1570                 1575             


Ala Thr  Leu Leu Asp Ile Tyr  Lys Thr Gly Glu Ala  Val Ala Glu 
    1580                 1585                 1590             


Lys Asp  Ser Glu Ile Thr Phe  Ile Lys Lys Val Thr  Cys Thr Asn 
    1595                 1600                 1605             


Ala Glu  Leu Val Lys Gly Arg  Gln Tyr Leu Ile Met  Gly Lys Glu 
    1610                 1615                 1620             


Ala Leu  Gln Ile Lys Tyr Asn  Phe Ser Phe Arg Tyr  Ile Tyr Pro 
    1625                 1630                 1635             


Leu Asp  Ser Leu Thr Trp Ile  Glu Tyr Trp Pro Arg  Asp Thr Thr 
    1640                 1645                 1650             


Cys Ser  Ser Cys Gln Ala Phe  Leu Ala Asn Leu Asp  Glu Phe Ala 
    1655                 1660                 1665             


Glu Asp  Ile Phe Leu Asn Gly  Cys 
    1670                 1675     


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide (1)

<400>  31

Met Lys Trp Ser Trp Val Ile Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide (2)

<400>  32

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  33
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-C5 mAb VH no mutation - nucleic acid

<400>  33
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggcta catattcagt aactactgga tacagtgggt gcgacaggcc      120

cctggacaag gccttgagtg gatgggtgag attttacctg gaagtggttc tactgagtac      180

actgagaact tcaaggacag ggtcaccatg actagggata catccacgag cacagtctac      240

atggagctca gcagcctgag atcagaggac acggccgtct attactgtgc aagatatttc      300

ttcggtagta gccccaactg gtacttcgat gtctggggcc aggggaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  34
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-C5 mAb VL no mutation - nucleic acid

<400>  34
gacatccaga tgactcagtc tccatcttca ctgtctgcat ctgtgggaga ccgggtcacc       60

atcacatgtg gagcaagtga gaatatttac ggtgctttaa attggtatca gcagaaacct      120

ggaaaagcac ctaagctcct gatctatggt gcaaccaact tggcagatgg cgtcccttcg      180

aggttcagtg gcagtggatc tggtaccgat ttcacgctca ctatcagtag cctgcagcct      240

gaggatttcg caacgtatta ctgtcaaaat gtgttaaata ctcctctcac gttcggtcag      300

gggaccaagg tggagatcaa a                                                321


<210>  35
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H-CDR1 containing Y32H - nucleic acid

<400>  35
ggctacatat tcagtaacca ttggatacag                                        30


<210>  36
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H-CDR2 of anti-C5 mAb VH no mutation - nucleic acid

<400>  36
gagattttac ctggaagtgg ttctactgag                                        30


<210>  37
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H-CDR3 of anti-C5 mAb VH no mutation - nucleic acid

<400>  37
gcaagatatt tcttcggtag tagccccaac tggtacttcg atgtc                       45


<210>  38
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-CDR1 of anti-C5 mAb VL no mutation - nucleic acid

<400>  38
ggagcaagtg agaatattta cggtgcttta aat                                    33


<210>  39
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-CDR2 of anti-C5 mAb VL no mutation - nucleic acid

<400>  39
tatggtgcaa ccaacttggc agat                                              24


<210>  40
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-CDR3 of anti-C5 mAb VL no mutation - nucleic acid

<400>  40
caaaatgtgt taaatactcc tctcacg                                           27


<210>  41
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH of Y32H mutant - nucleic acid

<400>  41
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggcta catattcagt aaccattgga tacagtgggt gcgacaggcc      120

cctggacaag gccttgagtg gatgggtgag attttacctg gaagtggttc tactgagtac      180

actgagaact tcaaggacag ggtcaccatg actagggata catccacgag cacagtctac      240

atggagctca gcagcctgag atcagaggac acggccgtct attactgtgc aagatatttc      300

ttcggtagta gccccaactg gtacttcgat gtctggggcc aggggaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  42
<211>  2268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH of Y32H-IgG4PLA-fH1-5 - nucleic acid

<400>  42
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggcta catattcagt aaccattgga tacagtgggt gcgacaggcc      120

cctggacaag gccttgagtg gatgggtgag attttacctg gaagtggttc tactgagtac      180

actgagaact tcaaggacag ggtcaccatg actagggata catccacgag cacagtctac      240

atggagctca gcagcctgag atcagaggac acggccgtct attactgtgc aagatatttc      300

ttcggtagta gccccaactg gtacttcgat gtctggggcc aggggaccct ggtcaccgtc      360

tcctcagcta gcaccaaggg cccatcggtc ttccccctgg cgccctgctc caggagcacc      420

tccgagagca cagccgccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacg      600

aagacctaca cctgcaacgt agatcacaag cccagcaaca ccaaggtgga caagagagtt      660

gagtccaaat atggtccccc atgcccacca tgcccagcac ctgagttcct ggggggacca      720

tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag      780

gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac      840

gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag      960

tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga gccacaggtg tacaccttgc caccctccca ggaggagatg     1080

acaaaaaatc aggtaagtct cacatgcctg gtcaaaggtt tttacccatc cgacattgct     1140

gtagagtggg aatccaacgg tcagcccgag aacaactaca agacaactcc cccagtcttg     1200

gactcagatg gctccttctt cttgtatagt agactgacag ttgataaaag ccgctggcaa     1260

gaaggcaatg tctttagctg tagtgtcctg catgaagcac ttcacgccca ttatacacaa     1320

aaatccctca gccttagcct agggaaggag gattgtaatg aactgcctcc aagaaggaac     1380

acagaaattt tgaccgggtc ctggtccgat caaacctacc ctgaaggaac tcaagctata     1440

tacaagtgca gacctggtta tagatcactg ggcaacatta tcatggtatg tcgcaaagga     1500

gaatgggtgg ctctgaatcc cctcagaaaa tgccagaaac ggccatgtgg acaccccggc     1560

gataccccat tcgggacatt taccttgact ggaggcaatg tattcgagta tggcgtgaaa     1620

gctgtctata cctgtaacga aggttaccaa ttgttgggag aaataaatta cagagaatgt     1680

gataccgatg gatggaccaa cgatattccc atatgcgagg ttgttaagtg cttgcctgtc     1740

actgcaccag aaaacgggaa aatcgtatct agcgcaatgg agccagaccg cgaataccat     1800

ttcgggcagg cagtgaggtt tgtttgcaat tccggttata agatagaagg ggatgaggag     1860

atgcactgta gcgacgatgg tttttggtcc aaggaaaagc ccaagtgcgt cgaaataagt     1920

tgcaagtcac ctgacgtcat aaacgggagc cccatatccc aaaagataat ttacaaggag     1980

aacgaacgat ttcaatataa gtgtaatatg gggtatgaat actccgagag aggtgatgcc     2040

gtctgtaccg aaagtggatg gcgaccactc ccctcatgcg aagagaagtc ctgtgataat     2100

ccatacatcc ctaatggtga ttattccccc cttcgaataa agcatcggac aggagacgag     2160

atcacatatc agtgtcgcaa cggattctat ccagccacca gaggcaacac tgcaaagtgt     2220

acatctacag gatggatacc tgccccacga tgtaccttga agccctga                  2268


<210>  43
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-CDR1 containing E27H - nucleic acid

<400>  43
ggagcaagtc ataatattta cggtgcttta aat                                    33


<210>  44
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-CDR1 containing N28H - nucleic acid

<400>  44
ggagcaagtg agcatattta cggtgcttta aat                                    33


<210>  45
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-CDR1 containing Y30H - nucleic acid

<400>  45
ggagcaagtg agaatattca cggtgcttta aat                                    33


<210>  46
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-CDR2 containing T52H - nucleic acid

<400>  46
tatggtgcac acaacttggc agat                                              24


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-CDR2 containing L54H - nucleic acid

<400>  47
tatggtgcaa ccaaccatgc agat                                              24


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-CDR2 containing D56H - nucleic acid

<400>  48
tatggtgcaa ccaacttggc acat                                              24


<210>  49
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L-CDR3 containg T97H - nucleic acid

<400>  49
caaaatgtgt taaatactcc tctccac                                           27


<210>  50
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kappa light chain, Q38R - nucleic acid

<400>  50
gacatccaga tgactcagtc tccatcttca ctgtctgcat ctgtgggaga ccgggtcacc       60

atcacatgtg gagcaagtga gaatatttac ggtgctttaa attggtatca gcggaaacct      120

ggaaaagcac ctaagctcct gatctatggt gcaaccaact tggcagatgg cgtcccttcg      180

aggttcagtg gcagtggatc tggtaccgat ttcacgctca ctatcagtag cctgcagcct      240

gaggatttcg caacgtatta ctgtcaaaat gtgttaaata ctcctctcac gttcggtcag      300

gggaccaagg tggagatcaa a                                                321


<210>  51
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kappa light chain, Q38R/E27H - nucleic acid

<400>  51
gacatccaga tgactcagtc tccatcttca ctgtctgcat ctgtgggaga ccgggtcacc       60

atcacatgtg gagcaagtca taatatttac ggtgctttaa attggtatca gcggaaacct      120

ggaaaagcac ctaagctcct gatctatggt gcaaccaact tggcagatgg cgtcccttcg      180

aggttcagtg gcagtggatc tggtaccgat ttcacgctca ctatcagtag cctgcagcct      240

gaggatttcg caacgtatta ctgtcaaaat gtgttaaata ctcctctcac gttcggtcag      300

gggaccaagg tggagatcaa a                                                321


<210>  52
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kappa light chain, Q38R/N28H - nucleic acid

<400>  52
gacatccaga tgactcagtc tccatcttca ctgtctgcat ctgtgggaga ccgggtcacc       60

atcacatgtg gagcaagtga gcatatttac ggtgctttaa attggtatca gcggaaacct      120

ggaaaagcac ctaagctcct gatctatggt gcaaccaact tggcagatgg cgtcccttcg      180

aggttcagtg gcagtggatc tggtaccgat ttcacgctca ctatcagtag cctgcagcct      240

gaggatttcg caacgtatta ctgtcaaaat gtgttaaata ctcctctcac gttcggtcag      300

gggaccaagg tggagatcaa a                                                321


<210>  53
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kappa light chain, Q38R/Y30H - nucleic acid

<400>  53
gacatccaga tgactcagtc tccatcttca ctgtctgcat ctgtgggaga ccgggtcacc       60

atcacatgtg gagcaagtga gaatattcac ggtgctttaa attggtatca gcggaaacct      120

ggaaaagcac ctaagctcct gatctatggt gcaaccaact tggcagatgg cgtcccttcg      180

aggttcagtg gcagtggatc tggtaccgat ttcacgctca ctatcagtag cctgcagcct      240

gaggatttcg caacgtatta ctgtcaaaat gtgttaaata ctcctctcac gttcggtcag      300

gggaccaagg tggagatcaa a                                                321


<210>  54
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kappa light chain, Q38R/T52H - nucleic acid

<400>  54
gacatccaga tgactcagtc tccatcttca ctgtctgcat ctgtgggaga ccgggtcacc       60

atcacatgtg gagcaagtga gaatatttac ggtgctttaa attggtatca gcggaaacct      120

ggaaaagcac ctaagctcct gatctatggt gcacacaact tggcagatgg cgtcccttcg      180

aggttcagtg gcagtggatc tggtaccgat ttcacgctca ctatcagtag cctgcagcct      240

gaggatttcg caacgtatta ctgtcaaaat gtgttaaata ctcctctcac gttcggtcag      300

gggaccaagg tggagatcaa a                                                321


<210>  55
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kappa light chain, Q38R/L54H - nucleic acid

<400>  55
gacatccaga tgactcagtc tccatcttca ctgtctgcat ctgtgggaga ccgggtcacc       60

atcacatgtg gagcaagtga gaatatttac ggtgctttaa attggtatca gcggaaacct      120

ggaaaagcac ctaagctcct gatctatggt gcaaccaacc atgcagatgg cgtcccttcg      180

aggttcagtg gcagtggatc tggtaccgat ttcacgctca ctatcagtag cctgcagcct      240

gaggatttcg caacgtatta ctgtcaaaat gtgttaaata ctcctctcac gttcggtcag      300

gggaccaagg tggagatcaa a                                                321


<210>  56
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kappa light chain, Q38R/D56H - nucleic acid

<400>  56
gacatccaga tgactcagtc tccatcttca ctgtctgcat ctgtgggaga ccgggtcacc       60

atcacatgtg gagcaagtga gaatatttac ggtgctttaa attggtatca gcggaaacct      120

ggaaaagcac ctaagctcct gatctatggt gcaaccaact tggcacatgg cgtcccttcg      180

aggttcagtg gcagtggatc tggtaccgat ttcacgctca ctatcagtag cctgcagcct      240

gaggatttcg caacgtatta ctgtcaaaat gtgttaaata ctcctctcac gttcggtcag      300

gggaccaagg tggagatcaa a                                                321


<210>  57
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kappa light chain, Q38R/T97H - nucleic acid

<400>  57
gacatccaga tgactcagtc tccatcttca ctgtctgcat ctgtgggaga ccgggtcacc       60

atcacatgtg gagcaagtga gaatatttac ggtgctttaa attggtatca gcggaaacct      120

ggaaaagcac ctaagctcct gatctatggt gcaaccaact tggcagatgg cgtcccttcg      180

aggttcagtg gcagtggatc tggtaccgat ttcacgctca ctatcagtag cctgcagcct      240

gaggatttcg caacgtatta ctgtcaaaat gtgttaaata ctcctctcca cttcggtcag      300

gggaccaagg tggagatcaa a                                                321


<210>  58
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc with PLA mutations - nucleic acid

<400>  58
gctagcacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggctc accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gctgcatgag gctctgcacg cccactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  59
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y32H heavy chain with PLA mutation - nucleic acid

<400>  59
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggcta catattcagt aaccattgga tacagtgggt gcgacaggcc      120

cctggacaag gccttgagtg gatgggtgag attttacctg gaagtggttc tactgagtac      180

actgagaact tcaaggacag ggtcaccatg actagggata catccacgag cacagtctac      240

atggagctca gcagcctgag atcagaggac acggccgtct attactgtgc aagatatttc      300

ttcggtagta gccccaactg gtacttcgat gtctggggcc aggggaccct ggtcaccgtc      360

tcctcagcta gcaccaaggg cccatcggtc ttccccctgg cgccctgctc caggagcacc      420

tccgagagca cagccgccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacg      600

aagacctaca cctgcaacgt agatcacaag cccagcaaca ccaaggtgga caagagagtt      660

gagtccaaat atggtccccc atgcccacca tgcccagcac ctgagttcct ggggggacca      720

tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag      780

gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac      840

gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag      960

tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aggctcaccg tggacaagag caggtggcag     1260

gaggggaatg tcttctcatg ctccgtgctg catgaggctc tgcacgccca ctacacacag     1320

aagagcctct ccctgtctct gggtaaa                                         1347


<210>  60
<211>  2268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y32H heavy chain with PLA mutation factor H fusion - nucleic acid

<400>  60
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggcta catattcagt aaccattgga tacagtgggt gcgacaggcc      120

cctggacaag gccttgagtg gatgggtgag attttacctg gaagtggttc tactgagtac      180

actgagaact tcaaggacag ggtcaccatg actagggata catccacgag cacagtctac      240

atggagctca gcagcctgag atcagaggac acggccgtct attactgtgc aagatatttc      300

ttcggtagta gccccaactg gtacttcgat gtctggggcc aggggaccct ggtcaccgtc      360

tcctcagcta gcaccaaggg cccatcggtc ttccccctgg cgccctgctc caggagcacc      420

tccgagagca cagccgccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacg      600

aagacctaca cctgcaacgt agatcacaag cccagcaaca ccaaggtgga caagagagtt      660

gagtccaaat atggtccccc atgcccacca tgcccagcac ctgagttcct ggggggacca      720

tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag      780

gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac      840

gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag      960

tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aggctcaccg tggacaagag caggtggcag     1260

gaggggaatg tcttctcatg ctccgtgctg catgaggctc tgcacgccca ctacacacag     1320

aagagcctct ccctgtctct gggtaaagag gattgtaatg aactgcctcc aagaaggaac     1380

acagaaattt tgaccgggtc ctggtccgat caaacctacc ctgaaggaac tcaagctata     1440

tacaagtgca gacctggtta tagatcactg ggcaacatta tcatggtatg tcgcaaagga     1500

gaatgggtgg ctctgaatcc cctcagaaaa tgccagaaac ggccatgtgg acaccccggc     1560

gataccccat tcgggacatt taccttgact ggaggcaatg tattcgagta tggcgtgaaa     1620

gctgtctata cctgtaacga aggttaccaa ttgttgggag aaataaatta cagagaatgt     1680

gataccgatg gatggaccaa cgatattccc atatgcgagg ttgttaagtg cttgcctgtc     1740

actgcaccag aaaacgggaa aatcgtatct agcgcaatgg agccagaccg cgaataccat     1800

ttcgggcagg cagtgaggtt tgtttgcaat tccggttata agatagaagg ggatgaggag     1860

atgcactgta gcgacgatgg tttttggtcc aaggaaaagc ccaagtgcgt cgaaataagt     1920

tgcaagtcac ctgacgtcat aaacgggagc cccatatccc aaaagataat ttacaaggag     1980

aacgaacgat ttcaatataa gtgtaatatg gggtatgaat actccgagag aggtgatgcc     2040

gtctgtaccg aaagtggatg gcgaccactc ccctcatgcg aagagaagtc ctgtgataat     2100

ccatacatcc ctaatggtga ttattccccc cttcgaataa agcatcggac aggagacgag     2160

atcacatatc agtgtcgcaa cggattctat ccagccacca gaggcaacac tgcaaagtgt     2220

acatctacag gatggatacc tgccccacga tgtaccttga agccctga                  2268


<210>  61
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide (1) - nucleic acid

<400>  61
atgaaatgga gctgggttat tctcttcctc ctgtcagtaa ctgcaggtgt ccactcc          57


<210>  62
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide (2) - nucleic acid

<400>  62
atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60


