LISTA DE SECUENCIAS

<110> Pontificia Universidad Catolica de Chile et al
<120> Mtodo in vitro para el diagnstico y prediccin de la agresividad de cncer de tiroides y las posibilidades y tipo de ciruga de precisin para la remocin del tumor en un sujeto; kit; reactivos para conformar dicho kit; uso de los reactivos y uso de marcadores moleculares parte del mtodo.
<160> 17
<210> SEQ ID NO 1
<211> 6459 
<212> ADN
<213> Homo sapiens
<400> 1

cttcccccaa tcccctcagg ctcggctgcg cccggggccg cgggccggta cctgaggtgg 60 cccaggcgcc ctccgcccgc ggcgccgccc gggccgctcc tccccgcgcc ccccgcgccc 120
cccgctcctc cgcctccgcc tccgcctccg cctcccccag ctctccgcct cccttccccc 180
tccccgcccg acagcggccg ctcgggcccc ggctctcggt tataagatgg cggcgctgag 240
cggtggcggt ggtggcggcg cggagccggg ccaggctctg ttcaacgggg acatggagcc 300
cgaggccggc gccggcgccg gcgccgcggc ctcttcggct gcggaccctg ccattccgga 360
ggaggtgtgg aatatcaaac aaatgattaa gttgacacag gaacatatag aggccctatt 420
ggacaaattt ggtggggagc ataatccacc atcaatatat ctggaggcct atgaagaata 480
caccagcaag ctagatgcac tccaacaaag agaacaacag ttattggaat ctctggggaa 540
cggaactgat ttttctgttt ctagctctgc atcaatggat accgttacat cttcttcctc 600
ttctagcctt tcagtgctac cttcatctct ttcagttttt caaaatccca cagatgtggc 660
acggagcaac cccaagtcac cacaaaaacc tatcgttaga gtcttcctgc ccaacaaaca 720
gaggacagtg gtacctgcaa ggtgtggagt tacagtccga gacagtctaa agaaagcact 780
gatgatgaga ggtctaatcc cagagtgctg tgctgtttac agaattcagg atggagagaa 840
gaaaccaatt ggttgggaca ctgatatttc ctggcttact ggagaagaat tgcatgtgga 900
agtgttggag aatgttccac ttacaacaca caactttgta cgaaaaacgt ttttcacctt 960
agcattttgt gacttttgtc gaaagctgct tttccagggt ttccgctgtc aaacatgtgg 1020
ttataaattt caccagcgtt gtagtacaga agttccactg atgtgtgtta attatgacca 1080
acttgatttg ctgtttgtct ccaagttctt tgaacaccac ccaataccac aggaagaggc 1140
gtccttagca gagactgccc taacatctgg atcatcccct tccgcacccg cctcggactc 1200
tattgggccc caaattctca ccagtccgtc tccttcaaaa tccattccaa ttccacagcc 1260
cttccgacca gcagatgaag atcatcgaaa tcaatttggg caacgagacc gatcctcatc 1320
agctcccaat gtgcatataa acacaataga acctgtcaat attgatgact tgattagaga 1380
ccaaggattt cgtggtgatg gaggatcaac cacaggtttg tctgctaccc cccctgcctc 1440
attacctggc tcactaacta acgtgaaagc cttacagaaa tctccaggac ctcagcgaga 1500
aaggaagtca tcttcatcct cagaagacag gaatcgaatg aaaacacttg gtagacggga 1560
ctcgagtgat gattgggaga ttcctgatgg gcagattaca gtgggacaaa gaattggatc 1620
tggatcattt ggaacagtct acaagggaaa gtggcatggt gatgtggcag tgaaaatgtt 1680
gaatgtgaca gcacctacac ctcagcagtt acaagccttc aaaaatgaag taggagtact 1740
caggaaaaca cgacatgtga atatcctact cttcatgggc tattccacaa agccacaact 1800
ggctattgtt acccagtggt gtgagggctc cagcttgtat caccatctcc atatcattga 1860
gaccaaattt gagatgatca aacttataga tattgcacga cagactgcac agggcatgga 1920
ttacttacac gccaagtcaa tcatccacag agacctcaag agtaataata tatttcttca 1980
tgaagacctc acagtaaaaa taggtgattt tggtctagct acagtgaaat ctcgatggag 2040
tgggtcccat cagtttgaac agttgtctgg atccattttg tggatggcac cagaagtcat 2100
cagaatgcaa gataaaaatc catacagctt tcagtcagat gtatatgcat ttggaattgt 2160
tctgtatgaa ttgatgactg gacagttacc ttattcaaac atcaacaaca gggaccagat 2220
aatttttatg gtgggacgag gatacctgtc tccagatctc agtaaggtac ggagtaactg 2280
tccaaaagcc atgaagagat taatggcaga gtgcctcaaa aagaaaagag atgagagacc 2340
actctttccc caaattctcg cctctattga gctgctggcc cgctcattgc caaaaattca 2400
ccgcagtgca tcagaaccct ccttgaatcg ggctggtttc caaacagagg attttagtct 2460
atatgcttgt gcttctccaa aaacacccat ccaggcaggg ggatatggtg cgtttcctgt 2520
ccactgaaac aaatgagtga gagagttcag gagagtagca acaaaaggaa aataaatgaa 2580
catatgtttg cttatatgtt aaattgaata aaatactctc ttttttttta aggtgaacca 2640
aagaacactt gtgtggttaa agactagata taatttttcc ccaaactaaa atttatactt 2700
aacattggat ttttaacatc caagggttaa aatacataga cattgctaaa aattggcaga 2760
gcctcttcta gaggctttac tttctgttcc gggtttgtat cattcacttg gttattttaa 2820
gtagtaaact tcagtttctc atgcaacttt tgttgccagc tatcacatgt ccactaggga 2880
ctccagaaga agaccctacc tatgcctgtg tttgcaggtg agaagttggc agtcggttag 2940
cctgggttag ataaggcaaa ctgaacagat ctaatttagg aagtcagtag aatttaataa 3000
ttctattatt attcttaata atttttctat aactatttct ttttataaca atttggaaaa 3060
tgtggatgtc ttttatttcc ttgaagcaat aaactaagtt tctttttata aattttgagt 3120
gcaggtgacc aaaaatattg ctgaggagtg gcacgtttga catgagtaaa atgtcttaac 3180
ttcggatttt tagcgggaaa atgttataaa ttggagtttc ttttaaatag ctttttttaa 3240
aatacattaa ggatgtctcg ctcatgtaga agtcaaattt tgttgcaaac gcattgctcc 3300
cttcacaccc aatctctccc ctgcaaaaaa tcttcacaga attctgtgag aacttttagg 3360
tgtgtttttc tttgagatac ctctggttgc caaacaccag gtaatagatt ttttaaagtt 3420
gttattagat tattcttacc tctcatgatg catattttag caatcacctt atcattgtgt 3480
ctcatgttct gtcctcctta tattctttgc ccagcaagat tctacttatg atgaatgaat 3540
gctcttctcc ttttttcatt caatggtatg aagtatttgt tagggttctt tagtacttac 3600
actttgttgt gtagaaaatg actgtaatgt ggtggtcagt gtattcttac tgtgattcag 3660
agggaatcaa aagtagaaag caacagcacg tggtcctatc aaagatttgg ccatctctgc 3720
ttcactgtca gcctcttaac tatatcttca cttactcaat ttggttttgt catgattttt 3780
aaatgtagcc aatagatcaa ggttcttcca gtaaacacat atctgcataa atgcctcctt 3840
gaagtcaata aagaaggaaa ttgagaagac tttaaattaa tgataattta gtttttaagt 3900
acccacaaat aaatttttga aacattttct ttatttgaat acttagatgt catccaggaa 3960
aatcactcaa taataattac ggcaaatctt taacccctca tttgggtagc ttaagataag 4020
taatgccatt atgaatcaga attgattcat gactttagtt aagaaaatga aaaggaacat 4080
ttcacgtatt tttaaaaatg atactaagga ataaagaagt acaactattg gaaaatatct 4140
aagtatatga tttttaaatc ctccagtggc attaaatata tgattattag taattgttag 4200
atagggtttt attcattcac aaatagaaga ctagcaagca tgtaactaac aaagttttta 4260
caaaattgac tttgtggaat gctccaaatg tttggccatt ttgaggcaca aggtcagggg 4320
tctctttatt gatagagctc cttctataat ttcccagcat acctgcctca cagttatctt 4380
cctttcattg ttcactctct ttttcttctc aatgccatcc tgcctaggct cccatcatct 4440
gcatctgaca cctttccttt ctttctttac tagtctcctt tgcgatgggt gtggctaagc 4500
tctgtagagc cactcagaaa ctcattgttc cattctgtag ccagtaaaac atgcctccaa 4560 agtgtcacag agtaattcta ctctctcttt taaattaggt ccaccggaaa tgttagtgaa 4620
aggacattaa aaatgtgaca ggtgacatgt ttagctaaca tggatctgga gaaataggaa 4680
gcagtagaat taaatgtttc cctttcaggt ttaattgtat ttgttcttgg gttttgtttt 4740
atactgagtt ttaaatatat tctccaaata aaaacattat tttttctaac catatgtaga 4800
gttaatctct ttgactaagt aattgaaaca aaagaacatt tgttcttttg tgactgcttt 4860
tttcctaaaa cctgagccct cttttttttt tttgaaatta aagttgattt cctttttttt 4920
tttttttttt tttttttttt tttttttttt tttgagacag agtctcgctc tgtcgcccag 4980
gctggagtgc agtggcggga tctcggctca ctgcaagctc cgcctcccgg gttcacgcca 5040
ttctcctgcc tcagcctccc aagtagctgg gactacaggc gcccgccact acgcccggct 5100
aattttttgt atttttagta gagacggggt ttcaccgttt tagccgggat ggtctcgatc 5160
tcctgacctc gtgatccgcc cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc 5220 caccgcgccc ggccttaaaa gttgatttcc ttcttcagta aggaaacctt tttataaatt 5280
tgttttgcat tttaaaagtt ttactaatca atgatgagga aaaagatttg tcttcttgat 5340
tttaaatagt ttcaggatca caggatgtaa tcagatgctt ccagtttatt tattttcagg 5400
tattacacta gccatttaat cttttttatt tatttatttt cttcctgccc ctcggatggc 5460
atataccagc catttagata ctaaactcta atagttaaac caatagttaa aattgtcctc 5520
tctaaaacat tggctattta atataccagc ttaaatggcc tttctctcaa gtgagtcact 5580
cttagtttaa gaaaattatg tgccttttta aaaaatatta tgaaatggta cttcatgaca 5640
gaaacatttt atcagttata gtcttatttg attgaaaatt gttgagcatt tctgtaaaac 5700
tttttacttt actaaatatt tcatctttcc tgtgactgtt ttctcaaaga atttaaaaga 5760
ctcgatgtgt ctatgccaga atgtttctca tccttttgaa actgcctggg ccaggcgtag 5820
tggctcacgc tgtaatccca gcacttttgg aggccaaggt gggcagatcg cgtgagccca 5880 ggagtttgag accagcctgg acaacatggc gaaacggtgt ctctacagaa aaatttaaaa 5940
attagccaag catagtggtg cacaactgta gccccagcca ctcgggaggc tgacgtggga 6000
ggatcccttg aacctggggg cggaggctgc tgtgagcctt catcatgcca ctgcactcca 6060
gcctgggcaa caaagcaaaa ccctgtctca aaaaaagaaa agaaaaaaag aaactgcttg 6020
aaagtcatga cgaagaatgt caggagggga cttattctgg ctgcagttga ctttctcctt 6080
aaatgtcaag tagtgattga tttggataag aagtaaactg ttacttttca taacatactt 6240
taaggaattt atcaaattct atgtataatg cccattaaaa tatactccat tctggagtaa 6300
agggtaagag taatattttt aaactagtta ataaagtctt tagctttcac ataaaccatg 6360
atatttgagg tgtctaaaat cacagggtct tttttttttt tttcagtctt cccagttgtt 6420
ctctgctcta ttcctaaata aagttaactt gaaaatgca                        6459


<210> SEQ ID NO 2
<211> 766 
<212> PRT
<213> Homo sapiens
<400> 2

Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15    
Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30           
Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45                
Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                 
Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu
65                  70                  75                  80 
Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95     
Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110
Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125            
Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val
    130                 135                 140                 
Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe
145                 150                 155                 160
Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     
Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         
Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205            
Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val
    210                 215                 220                 
Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 
Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255       
Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         
Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285               
Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                  
Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320
Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335    
Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350        
His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365              
Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 
Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 400                 405
Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                410                 415                 420    
Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser
            425                 430                 435         
Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        440                 445                 450             
Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    455                 460                 465                
Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
470                 475                 480                 485
Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                490                 495                 500     
Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            505                 510                 515        
Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        520                 525                 530             
Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    535                 540                 545                 
Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
550                 555                 560                 565  
Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                570                 575                 580    
Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            585                 590                 595         
Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        600                 605                 610             
Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    615                 620                 625                  
Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
630                 635                 640                 645
Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                650                 655                 660        
Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            665                 670                 675         
Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        680                 685                 690             
Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    695                 700                 705                 
Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
710                 715                 720                 725 
Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                730                 735                 740    
Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            745                 750                 755        
Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His
        760                 765                 770 

<210> SEQ ID NO 3
<211> 2757
<212> ADN
<213> Homo sapiens
<400> 3

gacaagtact gagtgaactc aaaccctctg taaagtaaca gaagttagaa ggggaaatgt 60
cgcctctctg aagattaccc aaagaaaaag tgatttgtca ttgctttata gactgtaaga 120
agagaacatc tcagaagtgg agtcttaccc tgaaatcaaa ggatttaaag aaaaagtgga 180
atttttcttc agcaagctgt gaaactaaat ccacaacctt tggagaccca ggaacaccct 240
ccaatctctg tgtgttttgt aaacatcact ggagggtctt ctacgtgagc aattggattg 300
tcatcagccc tgcctgtttt gcacctggga agtgccctgg tcttacttgg gtccaaattg 360
ttggctttca cttttgaccc taagcatctg aagccatggg ccacacacgg aggcagggaa 420
catcaccatc caagtgtcca tacctcaatt tctttcagct cttggtgctg gctggtcttt 480
ctcacttctg ttcaggtgtt atccacgtga ccaaggaagt gaaagaagtg gcaacgctgt 540
cctgtggtca caatgtttct gttgaagagc tggcacaaac tcgcatctac tggcaaaagg 600
agaagaaaat ggtgctgact atgatgtctg gggacatgaa tatatggccc gagtacaaga 660
accggaccat ctttgatatc actaataacc tctccattgt gatcctggct ctgcgcccat 720
ctgacgaggg cacatacgag tgtgttgttc tgaagtatga aaaagacgct ttcaagcggg 780
aacacctggc tgaagtgacg ttatcagtca aagctgactt ccctacacct agtatatctg 840
actttgaaat tccaacttct aatattagaa ggataatttg ctcaacctct ggaggttttc 900
cagagcctca cctctcctgg ttggaaaatg gagaagaatt aaatgccatc aacacaacag 960
tttcccaaga tcctgaaact gagctctatg ctgttagcag caaactggat ttcaatatga 1020
caaccaacca cagcttcatg tgtctcatca agtatggaca tttaagagtg aatcagacct 1080
tcaactggaa tacaaccaag caagagcatt ttcctgataa cctgctccca tcctgggcca 1140
ttaccttaat ctcagtaaat ggaatttttg tgatatgctg cctgacctac tgctttgccc 1200 caagatgcag agagagaagg aggaatgaga gattgagaag ggaaagtgta cgccctgtat 1260
aacagtgtcc gcagaagcaa ggggctgaaa agatctgaag gtcccacctc catttgcaat 1320
tgacctcttc tgggaacttc ctcagatgga caagattacc ccaccttgcc ctttacgtat 1380
ctgctcttag gtgcttcttc acttcagttg ctttgcagga agtgtctaga ggaatatggt 1440
gggcacagaa gtagctctgg tgaccttgat caaggtgttt tgaaatgcag aattcttgag 1500
ttctggaagg gactttagag aataccagtg ttattaatga caaaggcact gaggcccagg 1560
gaggtgaccc gaattataaa ggccagcgcc agaacccaga tttcctaact ctggtgctct 1620
ttccctttat cagtttgact gtggcctgtt aactggtata tacatatata tgtcaggcaa 1680
agtgctgctg gaagtagaat ttgtccaata acaggtcaac ttcagagact atctgatttc 1740
ctaatgtcag agtagaagat tttatgctgc tgtttacaaa agcccaatgt aatgcatagg 1800
aagtatggca tgaacatctt taggagacta atggaaatat tattggtgtt tacccagtat 1860
tccatttttt tcattgtgtt ctctattgct gctctctcac tcccccatga ggtacagcag 1920
aaaggagaac tatccaaaac taatttcctc tgacatgtaa gacgaatgat ttaggtacgt 1980
caaagcagta gtcaaggagg aaagggatag tccaaagact taactggttc atattggact 2040
gataatctct ttaaatggct ttatgctagt ttgacctcat ttgtaaaata tttatgagaa 2100
agttctcatt taaaatgaga tcgttgttta cagtgtatgt actaagcagt aagctatctt 2160
caaatgtcta aggtagtaac tttccatagg gcctccttag atccctaaga tggctttttc 2220
tccttggtat ttctgggtct ttctgacatc agcagagaac tggaaagaca tagccaactg 2280
ctgttcatgt tactcatgac tcctttctct aaaactgcct tccacaattc actagaccag 2340
aagtggacgc aacttaagct gggataatca cattatcatc tgaaaatctg gagttgaaca 2400
gcaaaagaag acaacatttc tcaaatgcac atctcatggc agctaagcca catggctggg 2460
atttaaagcc tttagagcca gcccatggct ttagctacct cactatgctg cttcacaaac 2520
cttgctcctg tgtaaaacta tattctcagt gtagggcaga gaggtctaac accaacataa 2580
ggtactagca gtgtttcccg tattgacagg aatacttaac tcaataattc ttttcttttc 2640
catttagtaa cagttgtgat gactatgttt ctattctaag taattcctgt attctacagc 2700
agatactttg tcagcaatac taagggaaga aacaaagttg aaccgtttct ttaataa    2757


<210> SEQ ID NO 4
<211> 288
<212> PRT
<213> Homo sapiens
<400> 4

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
                5                   10                  15     
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30          
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45             
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60                 
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110          
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125            
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175    
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190        
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205            
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220                
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270        
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285            


<210> SEQ ID NO 5
<211> 1997
<212> ADN
<213> Homo sapiens
<400> 5

gctttctatt caagtgcctt ctgtgtgtgc acatgtgtaa tacatatctg ggatcaaagc 60
tatctatata aagtccttga ttctgtgtgg gttcaaacac atttcaaagc ttcaggatcc 120
tgaaaggttt tgctctactt cctgaagacc tgaacaccgc tcccataaag ccatggcttg 180
ccttggattt cagcggcaca aggctcagct gaacctggct accaggacct ggccctgcac 240
tctcctgttt tttcttctct tcatccctgt cttctgcaaa gcaatgcacg tggcccagcc 300
tgctgtggta ctggccagca gccgaggcat cgccagcttt gtgtgtgagt atgcatctcc 360
aggcaaagcc actgaggtcc gggtgacagt gcttcggcag gctgacagcc aggtgactga 420
agtctgtgcg gcaacctaca tgatggggaa tgagttgacc ttcctagatg attccatctg 480
cacgggcacc tccagtggaa atcaagtgaa cctcactatc caaggactga gggccatgga 540
cacgggactc tacatctgca aggtggagct catgtaccca ccgccatact acctgggcat 600
aggcaacgga acccagattt atgtaattga tccagaaccg tgcccagatt ctgacttcct 660
cctctggatc cttgcagcag ttagttcggg gttgtttttt tatagctttc tcctcacagc 720
tgtttctttg agcaaaatgc taaagaaaag aagccctctt acaacagggg tctatgtgaa 780
aatgccccca acagagccag aatgtgaaaa gcaatttcag ccttatttta ttcccatcaa 840
ttgagaaacc attatgaaga agagagtcca tatttcaatt tccaagagct gaggcaattc 900
taactttttt gctatccagc tatttttatt tgtttgtgca tttgggggga attcatctct 960
ctttaatata aagttggatg cggaacccaa attacgtgta ctacaattta aagcaaagga 1020
gtagaaagac agagctggga tgtttctgtc acatcagctc cactttcagt gaaagcatca 1080
cttgggatta atatggggat gcagcattat gatgtgggtc aaggaattaa gttagggaat 1140
ggcacagccc aaagaaggaa aaggcaggga gcgagggaga agactatatt gtacacacct 1200
tatatttacg tatgagacgt ttatagccga aatgatcttt tcaagttaaa ttttatgcct 1260
tttatttctt aaacaaatgt atgattacat caaggcttca aaaatactca catggctatg 1320
ttttagccag tgatgctaaa ggttgtattg catatataca tatatatata tatatatata 1380
tatatatata tatatatata tatatatata tatattttaa tttgatagta ttgtgcatag 1440
agccacgtat gtttttgtgt atttgttaat ggtttgaata taaacactat atggcagtgt 1500
ctttccacct tgggtcccag ggaagttttg tggaggagct caggacacta atacaccagg 1560
tagaacacaa ggtcatttgc taactagctt ggaaactgga tgaggtcata gcagtgcttg 1620
attgcgtgga attgtgctga gttggtgttg acatgtgctt tggggctttt acaccagttc 1680
ctttcaatgg tttgcaagga agccacagct ggtggtatct gagttgactt gacagaacac 1740
tgtcttgaag acaatggctt actccaggag acccacaggt atgaccttct aggaagctcc 1800
agttcgatgg gcccaattct tacaaacatg tggttaatgc catggacaga agaaggcagc 1860
aggtggcaga atggggtgca tgaaggtttc tgaaaattaa cactgcttgt gtttttaact 1920
caatattttc catgaaaatg caacaacatg tataatattt ttaattaaat aaaaatctgt 1980
ggtggtcgtt ttccgga                                                1997


<210> SEQ ID NO 6
<211> 223
<212> PRT
<213> Homo sapiens
<400> 6

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
                5                   10                  15     
Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro
            20                  25                  30         
Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala
        35                  40                  45              
Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  
Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln
65                  70                  75                  80
Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      
Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110        
Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile
        115                 120                 125            
Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly
    130                 135                 140                 
Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser
145                 150                 155                 160    
Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175       
Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190        
Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205            
Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn
    210                 215                 220            

<210> SEQ ID NO 7
<211> 8515
<212> ADN
<213> Homo sapiens
<400> 7

gttctctcct ctcggaagct gcagccatga tggaagtttg agagttgagc cgctgtgagg 60
cgaggccggg ctcaggcgag ggagatgaga gacggcggcg gccgcggccc ggagcccctc 61
tcagcgcctg tgagcagccg cgggggcagc gccctcgggg agccggccgg cctgcggcgg 180
cggcagcggc ggcgtttctc gcctcctctt cgtcttttct aaccgtgcag cctcttcctc 240
ggcttctcct gaaagggaag gtggaagccg tgggctcggg cgggagccgg ctgaggcgcg 300
gcggcggcgg cggcacctcc cgctcctgga gcggggggga gaagcggcgg cggcggcggc 360
cgcggcggct gcagctccag ggagggggtc tgagtcgcct gtcaccattt ccagggctgg 420
gaacgccgga gagttggtct ctccccttct actgcctcca acacggcggc ggcggcggct 480
ggcacatcca gggacccggg ccggttttaa acctcccgtg cgccgccgcc gcaccccccg 540
tggcccgggc tccggaggcc gccggcggag gcagccgttc ggaggattat tcgtcttctc 600
cccattccgc tgccgccgct gccaggcctc tggctgctga ggagaagcag gcccagtcgc 660
tgcaaccatc cagcagccgc cgcagcagcc attacccggc tgcggtccag agccaagcgg 720
cggcagagcg aggggcatca gctaccgcca agtccagagc catttccatc ctgcagaaga 780
agccccgcca ccagcagctt ctgccatctc tctcctcctt tttcttcagc cacaggctcc 840
cagacatgac agccatcatc aaagagatcg ttagcagaaa caaaaggaga tatcaagagg 900
atggattcga cttagacttg acctatattt atccaaacat tattgctatg ggatttcctg 960
cagaaagact tgaaggcgta tacaggaaca atattgatga tgtagtaagg tttttggatt 1020
caaagcataa aaaccattac aagatataca atctttgtgc tgaaagacat tatgacaccg 1080
ccaaatttaa ttgcagagtt gcacaatatc cttttgaaga ccataaccca ccacagctag 1140
aacttatcaa acccttttgt gaagatcttg accaatggct aagtgaagat gacaatcatg 1201
ttgcagcaat tcactgtaaa gctggaaagg gacgaactgg tgtaatgata tgtgcatatt 1260
tattacatcg gggcaaattt ttaaaggcac aagaggccct agatttctat ggggaagtaa 1320
ggaccagaga caaaaaggga gtaactattc ccagtcagag gcgctatgtg tattattata 1380
gctacctgtt aaagaatcat ctggattata gaccagtggc actgttgttt cacaagatga 1440
tgtttgaaac tattccaatg ttcagtggcg gaacttgcaa tcctcagttt gtggtctgcc 1500
agctaaaggt gaagatatat tcctccaatt caggacccac acgacgggaa gacaagttca 1560
tgtactttga gttccctcag ccgttacctg tgtgtggtga tatcaaagta gagttcttcc 1620
acaaacagaa caagatgcta aaaaaggaca aaatgtttca cttttgggta aatacattct 1680
tcataccagg accagaggaa acctcagaaa aagtagaaaa tggaagtcta tgtgatcaag 1740
aaatcgatag catttgcagt atagagcgtg cagataatga caaggaatat ctagtactta 1800
ctttaacaaa aaatgatctt gacaaagcaa ataaagacaa agccaaccga tacttttctc 1860
caaattttaa ggtgaagctg tacttcacaa aaacagtaga ggagccgtca aatccagagg 1920
ctagcagttc aacttctgta acaccagatg ttagtgacaa tgaacctgat cattatagat 1980
attctgacac cactgactct gatccagaga atgaaccttt tgatgaagat cagcatacac 2040
aaattacaaa agtctgaatt tttttttatc aagagggata aaacaccatg aaaataaact 2100
tgaataaact gaaaatggac cttttttttt ttaatggcaa taggacattg tgtcagatta 2160
ccagttatag gaacaattct cttttcctga ccaatcttgt tttaccctat acatccacag 2220
ggttttgaca cttgttgtcc agttgaaaaa aggttgtgta gctgtgtcat gtatatacct 2280
ttttgtgtca aaaggacatt taaaattcaa ttaggattaa taaagatggc actttcccgt 2340
tttattccag ttttataaaa agtggagaca gactgatgtg tatacgtagg aattttttcc 2400
ttttgtgttc tgtcaccaac tgaagtggct aaagagcttt gtgatatact ggttcacatc 2460 ctaccccttt gcacttgtgg caacagataa gtttgcagtt ggctaagaga ggtttccgaa 2520
gggttttgct acattctaat gcatgtattc gggttagggg aatggaggga atgctcagaa 2580
aggaaataat tttatgctgg actctggacc atataccatc tccagctatt tacacacacc 2640
tttctttagc atgctacagt tattaatctg gacattcgag gaattggccg ctgtcactgc 2700
ttgttgtttg cgcatttttt tttaaagcat attggtgcta gaaaaggcag ctaaaggaag 2760
tgaatctgta ttggggtaca ggaatgaacc ttctgcaaca tcttaagatc cacaaatgaa 2820
gggatataaa aataatgtca taggtaagaa acacagcaac aatgacttaa ccatataaat 2880
gtggaggcta tcaacaaaga atgggcttga aacattataa aaattgacaa tgatttatta 2940
aatatgtttt ctcaattgta acgacttctc catctcctgt gtaatcaagg ccagtgctaa 3000
aattcagatg ctgttagtac ctacatcagt caacaactta cacttatttt actagttttc 3060
aatcataata cctgctgtgg atgcttcatg tgctgcctgc aagcttcttt tttctcatta 3120
aatataaaat attttgtaat gctgcacaga aattttcaat ttgagattct acagtaagcg 3180
ttttttttct ttgaagattt atgatgcact tattcaatag ctgtcagccg ttccaccctt 3240
ttgaccttac acattctatt acaatgaatt ttgcagtttt gcacattttt taaatgtcat 3300
taactgttag ggaattttac ttgaatactg aatacatata atgtttatat taaaaaggac 3361
atttgtgtta aaaaggaaat tagagttgca gtaaactttc aatgctgcac acaaaaaaaa 3420
gacatttgat ttttcagtag aaattgtcct acatgtgctt tattgatttg ctattgaaag 3480
aatagggttt tttttttttt tttttttttt ttttttaaat gtgcagtgtt gaatcatttc 3540
ttcatagtgc tcccccgagt tgggactagg gcttcaattt cacttcttaa aaaaaatcat 3600
catatatttg atatgcccag actgcatacg attttaagcg gagtacaact actattgtaa 3660
agctaatgtg aagatattat taaaaaggtt tttttttcca gaaatttggt gtcttcaaat 3720
tataccttca ccttgacatt tgaatatcca gccattttgt ttcttaatgg tataaaattc 3780
cattttcaat aacttattgg tgctgaaatt gttcactagc tgtggtctga cctagttaat 3840
ttacaaatac agattgaata ggacctacta gagcagcatt tatagagttt gatggcaaat 3900
agattaggca gaacttcatc taaaatattc ttagtaaata atgttgacac gttttccata 3960
ccttgtcagt ttcattcaac aatttttaaa tttttaacaa agctcttagg atttacacat 4020
ttatatttaa acattgatat atagagtatt gattgattgc tcataagtta aattggtaaa 4080
gttagagaca actattctaa cacctcacca ttgaaattta tatgccacct tgtctttcat 4140
aaaagctgaa aattgttacc taaaatgaaa atcaacttca tgttttgaag atagttataa 4200
atattgttct ttgttacaat ttcgggcacc gcatattaaa acgtaacttt attgttccaa 4260
tatgtaacat ggagggccag gtcataaata atgacattat aatgggcttt tgcactgtta 4320
ttatttttcc tttggaatgt gaaggtctga atgagggttt tgattttgaa tgtttcaatg 4380
tttttgagaa gccttgctta cattttatgg tgtagtcatt ggaaatggaa aaatggcatt 4440
atatatatta tatatataaa tatatattat acatactctc cttactttat ttcagttacc 4500
atccccatag aatttgacaa gaattgctat gactgaaagg ttttcgagtc ctaattaaaa 4560
ctttatttat ggcagtattc ataattagcc tgaaatgcat tctgtaggta atctctgagt 4620
ttctggaata ttttcttaga ctttttggat gtgcagcagc ttacatgtct gaagttactt 4680
gaaggcatca cttttaagaa agcttacagt tgggccctgt accatcccaa gtcctttgta 4740
gctcctcttg aacatgtttg ccatactttt aaaagggtag ttgaataaat agcatcacca 4800
ttctttgctg tggcacaggt tataaactta agtggagttt accggcagca tcaaatgttt 4860
cagctttaaa aaataaaagt agggtacaag tttaatgttt agttctagaa attttgtgca 4920
atatgttcat aacgatggct gtggttgcca caaagtgcct cgtttacctt taaatactgt 4981
taatgtgtca tgcatgcaga tggaaggggt ggaactgtgc actaaagtgg gggctttaac 5040 tgtagtattt ggcagagttg ccttctacct gccagttcaa aagttcaacc tgttttcata 5100
tagaatatat atactaaaaa atttcagtct gttaaacagc cttactctga ttcagcctct 5160
tcagatactc ttgtgctgtg cagcagtggc tctgtgtgta aatgctatgc actgaggata 5220
cacaaaaata ccaatatgat gtgtacagga taatgcctca tcccaatcag atgtccattt 5280
gttattgtgt ttgttaacaa ccctttatct cttagtgtta taaactccac ttaaaactga 5340
ttaaagtctc attcttgtca ttgtgtgggt gttttattaa atgagagttt ataattcaaa 5400
ttgcttaagt ccattgaagt tttaattaat gggcagccaa atgtgaatac aaagttttca 5460
gttttttttt ttcctgctgt ccttcaaagc ctactgttta aaaaaaaaaa aaaaaaaaaa 5520
catggcctga gagtagagta tctgtctact catgtttaat taaggaaaaa cacttatttt 5580
tagggcttta gtcatcactt cataaattgt ataagcacat taaatagcgt tctagtcctg 5640
aaaaagtcca agattcttag aaaattgtgc atatttttat tatgacagat gtttgaagat 5700
aattccccag aatggatttg atactttaga tttcaatttt gtggcttttg tctattattc 5760 tgtactctgc catcagcata tggaaagctt catttactca tcatgacttg tgccatataa 5821
aaattgatat ttcggaatag tctaaaggac tttttgtact tgaatttaat catgttgttt 5880
ctaatattct taaaagcttg aagactaaag catatccttt caacaaagca tagtaaggta 5971
ataagaaagt gtagtttgta caagtgttaa aaaaataaag tagacaatgt tacagtggga 6000
cttattattt caagtttaca ttttctccat gtaatttttt aaaaagtaaa tgaaaaaatg 6060
tgcaataatg taaaatatga agtgtatgtg tacacacatt ttatttttcg gtatcttggg 6120
tatacgtatg gttgaaaact atactggagt ctaaaagtat tctaatttat aagaagacat 6180
tttggtgatg tttgaaaaat agaaatgtgc tagttttgtt tttatatcat gtcctttgta 6240
cgttgtaata tgagctggct tggttcagta aatgccatca ccatttccat tgagaattta 6300
aaactcacca gtgtttaata tgcaggcttc caaaggctta tgaaaaaaat caagaccctt 6360
aaatctagtt aatttgctgc taacatgaaa ctctttggtt cttttatttt tgccagataa 6420
ttagacacac atctaaagct tagtcttaaa tggcttaagt gtagctattg attagtgctg 6480
ttgctagttc agaaagaaat gtttgtgaat ggaaacaaga atattcagtc caaactgttg 6540
taaggacagt acctgaaaac caggaaacag gataatggaa aaagtctttt aaagatgaaa 6600
tgttggagcc aactttctta tagaattaat tgtatgtggc tatagaaagc ctaatgattg 6660
ttgcttattt ttgagagcat attattcttt tatgaccata atcttgctgt ttttccatct 6720
tccaaaagat cttccttcta atatgtatat cagaatgtgg gtagccagtc agacaaattc 6780
atattggttg gtagctttaa aaagtttgta atgtgaagac aggaaaggac aaaatagttt 6840
gctttggtgg tagtactctg gttgttaagc taggtatttt gagactactt ccccatcaca 6900
acaacaataa aataatcact cataatccta tcacctggag acatagccat cgttaatatg 6960
ttagtgacta tacaatcatg ttttcttctg tatatccatg tatattcttt aaaaatgaaa 7020
tttatactgt acctgatctc aaagcttttt agcttagtat atctgtcatg aatttgtagg 7080
atgttccatt gcatcagaaa acggacagtg atttgattac tttctaatgc cacagatgca 7140
gattacatgt agttattgag aatcctttcg aattcagtgg cttaatcatg aatgtctaaa 7200
tattgttgac attaggatga tacatgtaaa ttaaagttac atttgtttag catagacaag 7260
cttaacattg tagatgtttc tcttcaaaaa tcatcttaaa catttgcatt tggaattgtg 7320
ttaaatagaa tgtgtgaaac actgtattag taaacttcat cacctttcta cttccttata 7380
gtttgaactt ttcagttttt gtagttccca aacagttgct caatttagag caaattaatt 7440
taacacctgc caaaaaaagg ctgctgttgg cttatcagtt gtctttaaat tcaaatgctc 7500
atgtgacttt tatcacatca aaaaatattt cattaatgat tcacctttag ctctgaaaat 7560
taccgcgttt agtaattata gtgggcttat aaaaacatgc aactcttttt gatagttatt 7620
tgagaatttt ggtgaaaaat atttagctga gggcagtata gaacttataa accaatatat 7680
tgatattttt aaaacatttt tacatataag taaactgcca tctttgagca taactacatt 7740
taaaaataaa gctgcatatt tttaaatcaa gtgtttaaca agaatttata ttttttattt 7800
tttaaaatta aaaataattt atatttcctc tgttgcatga ggattctcat ctgtgcttat 7860
aatggttaga gattttattt gtgtggaatg aagtgaggct tgtagtcatg gttctagtgt 7920
ttcagtttgc caagtctgtt tactgcagtg aaattcatca aatgtttcag tgtggttttc 7980
tgtagcctat catttactgg ctattttttt atgtacacct ttaggatttt ctgcctactc 8040
tatccagttg tccaaatgat atcctacatt ttacaaatgc cctttcagtt tctattttct 8100
ttttccatta aattgccctc atgtcctaat gtgcagtttg taagtgtgtg tgtgtgtgtc 8160 tgtgtgtgtg tgaatttgat tttcaagagt gctagacttc caatttgaga gattaaataa 8220
tttaattcag gcaaacattt ttcattggaa tttcacagtt cattgtaatg aaaatgttaa 8280
tcctggatga cctttgacat acagtaatga atcttggata ttaatgaatt tgttagtagc 8340
atcttgatgt gtgttttaat gagttatttt caaagttgtg cattaaacca aagttggcat 8400
actggaagtg tttatatcaa gttccatttg gctactgatg gacaaaaaat agaaatgcct 8460
tcctatggag agtatttttc ctttaaaaaa ttaaaaaggt taattatttt gacta      8515 


<210> SEQ ID NO 8
<211> 403
<212> PRT
<213> Homo sapiens
<400> 8

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
                5                   10                  15     
Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile
            20                  25                  30           
Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn
        35                  40                  45             
Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His
    50                  55                  60                 
Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys
65                  70                  75                  80
Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      
Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu
            100                 105                 110        
Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys
        115                 120                 125                
Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys
    130                 135                 140                  
Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr
145                 150                 155                 160 
Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr
                165                 170                 175      
Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala
            180                 185                 190          
Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly
        195                 200                 205               
Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile
    210                 215                 220                
Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr
225                 230                 235                 240   
Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255    
Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His
            260                 265                 270        
Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu
        275                 280                 285             
Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys
    290                 295                 300                  
Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu
305                 310                 315                 320
Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr
                325                 330                 335     
Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu
            340                 345                 350          
Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp
        355                 360                 365             
Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp
    370                 375                 380                
Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile
385                 390                 395                 400     
Thr Lys Val



<210> SEQ ID NO 9
<211> 2259
<212> ADN
<213> Homo sapiens
<400> 9

atgccctgcc cctgcgcccg ccgccgccgc cgccgccgct cagcccggcg cgctctggag 60
gatcctgcgc cgcggcgctc ccgggccccg ccgccgccag ccgccccgcc gccctcctcc 120
cgcccccggc accgccgcca gcgcccccgc cgcagcgccc gcggcccggc tcctctcact 180
tcggggaagg ggagggagga gggggacgag ggctctggcg ggtttggagg ggctgaacat 240
cgcggggtgt tctggtgtcc cccgccccgc ctctccaaaa agctacaccg acgcggaccg 300
cggcggcgtc ctccctcgcc ctcgcttcac ctcgcgggct ccgaatgcgg ggagctcgga 360
tgtccggttt cctgtgaggc ttttacctga cacccgccgc ctttccccgg cactggctgg 420
gagggcgccc tgcaaagttg ggaacgcgga gccccggacc cgctcccgcc gcctccggct 480
cgcccagggg gggtcgccgg gaggagcccg ggggagaggg accaggaggg gcccgcggcc 540
tcgcaggggc gcccgcgccc ccacccctgc ccccgccagc ggaccggtcc cccacccccg 600
gtccttccac catgcacttg ctgggcttct tctctgtggc gtgttctctg ctcgccgctg 660
cgctgctccc gggtcctcgc gaggcgcccg ccgccgccgc cgccttcgag tccggactcg 720
acctctcgga cgcggagccc gacgcgggcg aggccacggc ttatgcaagc aaagatctgg 780
aggagcagtt acggtctgtg tccagtgtag atgaactcat gactgtactc tacccagaat 840
attggaaaat gtacaagtgt cagctaagga aaggaggctg gcaacataac agagaacagg 900
ccaacctcaa ctcaaggaca gaagagacta taaaatttgc tgcagcacat tataatacag 960
agatcttgaa aagtattgat aatgagtgga gaaagactca atgcatgcca cgggaggtgt 1020
gtatagatgt ggggaaggag tttggagtcg cgacaaacac cttctttaaa cctccatgtg 1080
tgtccgtcta cagatgtggg ggttgctgca atagtgaggg gctgcagtgc atgaacacca 1140
gcacgagcta cctcagcaag acgttatttg aaattacagt gcctctctct caaggcccca 1200
aaccagtaac aatcagtttt gccaatcaca cttcctgccg atgcatgtct aaactggatg 1260 tttacagaca agttcattcc attattagac gttccctgcc agcaacacta ccacagtgtc 1320
aggcagcgaa caagacctgc cccaccaatt acatgtggaa taatcacatc tgcagatgcc 1380
tggctcagga agattttatg ttttcctcgg atgctggaga tgactcaaca gatggattcc 1440
atgacatctg tggaccaaac aaggagctgg atgaagagac ctgtcagtgt gtctgcagag 1500
cggggcttcg gcctgccagc tgtggacccc acaaagaact agacagaaac tcatgccagt 1560
gtgtctgtaa aaacaaactc ttccccagcc aatgtggggc caaccgagaa tttgatgaaa 1620
acacatgcca gtgtgtatgt aaaagaacct gccccagaaa tcaaccccta aatcctggaa 1680
aatgtgcctg tgaatgtaca gaaagtccac agaaatgctt gttaaaagga aagaagttcc 1740
accaccaaac atgcagctgt tacagacggc catgtacgaa ccgccagaag gcttgtgagc 1800
caggattttc atatagtgaa gaagtgtgtc gttgtgtccc ttcatattgg aaaagaccac 1860
aaatgagcta agattgtact gttttccagt tcatcgattt tctattatgg aaaactgtgt 1920
tgccacagta gaactgtctg tgaacagaga gacccttgtg ggtccatgct aacaaagaca 1980
aaagtctgtc tttcctgaac catgtggata actttacaga aatggactgg agctcatctg 2040
caaaaggcct cttgtaaaga ctggttttct gccaatgacc aaacagccaa gattttcctc 2100
ttgtgatttc tttaaaagaa tgactatata atttatttcc actaaaaata ttgtttctgc 2160
attcattttt atagcaacaa caattggtaa aactcactgt gatcaatatt tttatatcat 2220
gcaaaatatg tttaaaataa aatgaaaatt gtattataa                        2259

<210> SEQ ID NO 10
<211> 419
<212> PRT
<213> Homo sapiens
<400> 10

Met His Leu Leu Gly Phe Phe Ser Val Ala Cys Ser Leu Leu Ala Ala
                5                   10                  15      
Ala Leu Leu Pro Gly Pro Arg Glu Ala Pro Ala Ala Ala Ala Ala Phe
            20                  25                  30         
Glu Ser Gly Leu Asp Leu Ser Asp Ala Glu Pro Asp Ala Gly Glu Ala
        35                  40                  45              
Thr Ala Tyr Ala Ser Lys Asp Leu Glu Glu Gln Leu Arg Ser Val Ser
    50                  55                  60                  
Ser Val Asp Glu Leu Met Thr Val Leu Tyr Pro Glu Tyr Trp Lys Met
65                  70                  75                  80     
Tyr Lys Cys Gln Leu Arg Lys Gly Gly Trp Gln His Asn Arg Glu Gln
                85                  90                  95     
Ala Asn Leu Asn Ser Arg Thr Glu Glu Thr Ile Lys Phe Ala Ala Ala
            100                 105                 110        
His Tyr Asn Thr Glu Ile Leu Lys Ser Ile Asp Asn Glu Trp Arg Lys
        115                 120                 125            
Thr Gln Cys Met Pro Arg Glu Val Cys Ile Asp Val Gly Lys Glu Phe
    130                 135                 140                 
Gly Val Ala Thr Asn Thr Phe Phe Lys Pro Pro Cys Val Ser Val Tyr
145                 150                 155                 160
Arg Cys Gly Gly Cys Cys Asn Ser Glu Gly Leu Gln Cys Met Asn Thr
                165                 170                 175    
Ser Thr Ser Tyr Leu Ser Lys Thr Leu Phe Glu Ile Thr Val Pro Leu
            180                 185                 190         
Ser Gln Gly Pro Lys Pro Val Thr Ile Ser Phe Ala Asn His Thr Ser
        195                 200                 205            
Cys Arg Cys Met Ser Lys Leu Asp Val Tyr Arg Gln Val His Ser Ile
    210                 215                 220                 
Ile Arg Arg Ser Leu Pro Ala Thr Leu Pro Gln Cys Gln Ala Ala Asn
225                 230                 235                 240  
Lys Thr Cys Pro Thr Asn Tyr Met Trp Asn Asn His Ile Cys Arg Cys
                245                 250                 255    
Leu Ala Gln Glu Asp Phe Met Phe Ser Ser Asp Ala Gly Asp Asp Ser
            260                 265                 270        
Thr Asp Gly Phe His Asp Ile Cys Gly Pro Asn Lys Glu Leu Asp Glu
        275                 280                 285            
Glu Thr Cys Gln Cys Val Cys Arg Ala Gly Leu Arg Pro Ala Ser Cys
    290                 295                 300                
Gly Pro His Lys Glu Leu Asp Arg Asn Ser Cys Gln Cys Val Cys Lys
305                 310                 315                 320
Asn Lys Leu Phe Pro Ser Gln Cys Gly Ala Asn Arg Glu Phe Asp Glu
                325                 330                 335    
Asn Thr Cys Gln Cys Val Cys Lys Arg Thr Cys Pro Arg Asn Gln Pro
            340                 345                 350        
Leu Asn Pro Gly Lys Cys Ala Cys Glu Cys Thr Glu Ser Pro Gln Lys
        355                 360                 365            
Cys Leu Leu Lys Gly Lys Lys Phe His His Gln Thr Cys Ser Cys Tyr
    370                 375                 380                 
Arg Arg Pro Cys Thr Asn Arg Gln Lys Ala Cys Glu Pro Gly Phe Ser
385                 390                 395                 400 
Tyr Ser Glu Glu Val Cys Arg Cys Val Pro Ser Tyr Trp Lys Arg Pro
                405                 410                 415     
Gln Met Ser
           


<210> SEQ ID NO 11
<211> 22
<212> ARN
<213> Homo sapiens
<400> 11

uagcagcacg uaaauauugg cg                                  11



<210> SEQ ID NO 12
<211> 23
<212> ARN
<213> Homo sapiens
<400> 12

ugagaacuga auuccauagg cug                                           23


<210> SEQ ID NO 13
<211> 24
<212> ARN
<213> Homo sapiens
<400> 13

uuaaugcuaa ucgugauagg gguu                                          24



<210> SEQ ID NO 14
<211> 23
<212> ARN
<213> Homo sapiens
<400> 14

aacauucauu guugucggug ggu                                          23

<210> SEQ ID NO 15
<211> 107
<212> ADN
<213> Homo sapiens
<400> 15

gtgctcgctt cggcagcaca tatactaaaa ttggaacgat acagagaaga ttagcatggc 60
ccctgcgcaa ggatgacacg caaattcgtg aagcgttcca tattttt               107



<210> SEQ ID NO 16
<211> 5617
<212> ADN
<213> Homo sapiens
<400> 16

agtcccgcga ccgaagcagg gcgcgcagca gcgctgagtg ccccggaacg tgcgtcgcgc 60
ccccagtgtc cgtcgcgtcc gccgcgcccc gggcggggat ggggcggcca gactgagcgc 120
cgcacccgcc atccagaccc gccggcccta gccgcagtcc ctccagccgt ggccccagcg 180
cgcacgggcg atggcgaagg cgacgtccgg tgccgcgggg ctgcgtctgc tgttgctgct 240
gctgctgccg ctgctaggca aagtggcatt gggcctctac ttctcgaggg atgcttactg 300
ggagaagctg tatgtggacc aggcagccgg cacgcccttg ctgtacgtcc atgccctgcg 360
ggacgcccct gaggaggtgc ccagcttccg cctgggccag catctctacg gcacgtaccg 420
cacacggctg catgagaaca actggatctg catccaggag gacaccggcc tcctctacct 480
taaccggagc ctggaccata gctcctggga gaagctcagt gtccgcaacc gcggctttcc 540
cctgctcacc gtctacctca aggtcttcct gtcacccaca tcccttcgtg agggcgagtg 600
ccagtggcca ggctgtgccc gcgtatactt ctccttcttc aacacctcct ttccagcctg 660
cagctccctc aagccccggg agctctgctt cccagagaca aggccctcct tccgcattcg 720
ggagaaccga cccccaggca ccttccacca gttccgcctg ctgcctgtgc agttcttgtg 780
ccccaacatc agcgtggcct acaggctcct ggagggtgag ggtctgccct tccgctgcgc 840
cccggacagc ctggaggtga gcacgcgctg ggccctggac cgcgagcagc gggagaagta 900
cgagctggtg gccgtgtgca ccgtgcacgc cggcgcgcgc gaggaggtgg tgatggtgcc 960
cttcccggtg accgtgtacg acgaggacga ctcggcgccc accttccccg cgggcgtcga 1020
caccgccagc gccgtggtgg agttcaagcg gaaggaggac accgtggtgg ccacgctgcg 1080
tgtcttcgat gcagacgtgg tacctgcatc aggggagctg gtgaggcggt acacaagcac 1140
gctgctcccc ggggacacct gggcccagca gaccttccgg gtggaacact ggcccaacga 1200
gacctcggtc caggccaacg gcagcttcgt gcgggcgacc gtacatgact ataggctggt 1260
tctcaaccgg aacctctcca tctcggagaa ccgcaccatg cagctggcgg tgctggtcaa 1320
tgactcagac ttccagggcc caggagcggg cgtcctcttg ctccacttca acgtgtcggt 1380
gctgccggtc agcctgcacc tgcccagtac ctactccctc tccgtgagca ggagggctcg 1440
ccgatttgcc cagatcggga aagtctgtgt ggaaaactgc caggcattca gtggcatcaa 1500
cgtccagtac aagctgcatt cctctggtgc caactgcagc acgctagggg tggtcacctc 1560
agccgaggac acctcgggga tcctgtttgt gaatgacacc aaggccctgc ggcggcccaa 1620
gtgtgccgaa cttcactaca tggtggtggc caccgaccag cagacctcta ggcaggccca 1680
ggcccagctg cttgtaacag tggaggggtc atatgtggcc gaggaggcgg gctgccccct 1740
gtcctgtgca gtcagcaaga gacggctgga gtgtgaggag tgtggcggcc tgggctcccc 1800
aacaggcagg tgtgagtgga ggcaaggaga tggcaaaggg atcaccagga acttctccac 1860
ctgctctccc agcaccaaga cctgccccga cggccactgc gatgttgtgg agacccaaga 1920 catcaacatt tgccctcagg actgcctccg gggcagcatt gttgggggac acgagcctgg 1980
ggagccccgg gggattaaag ctggctatgg cacctgcaac tgcttccctg aggaggagaa 2040
gtgcttctgc gagcccgaag acatccagga tccactgtgc gacgagctgt gccgcacggt 2100
gatcgcagcc gctgtcctct tctccttcat cgtctcggtg ctgctgtctg ccttctgcat 2160
ccactgctac cacaagtttg cccacaagcc acccatctcc tcagctgaga tgaccttccg 2220
gaggcccgcc caggccttcc cggtcagcta ctcctcttcc ggtgcccgcc ggccctcgct 2280
ggactccatg gagaaccagg tctccgtgga tgccttcaag atcctggagg atccaaagtg 2340
ggaattccct cggaagaact tggttcttgg aaaaactcta ggagaaggcg aatttggaaa 2400
agtggtcaag gcaacggcct tccatctgaa aggcagagca gggtacacca cggtggccgt 2460
gaagatgctg aaagagaacg cctccccgag tgagctgcga gacctgctgt cagagttcaa 2520
cgtcctgaag caggtcaacc acccacatgt catcaaattg tatggggcct gcagccagga 2580
tggcccgctc ctcctcatcg tggagtacgc caaatacggc tccctgcggg gcttcctccg 2640
cgagagccgc aaagtggggc ctggctacct gggcagtgga ggcagccgca actccagctc 2700
cctggaccac ccggatgagc gggccctcac catgggcgac ctcatctcat ttgcctggca 2760
gatctcacag gggatgcagt atctggccga gatgaagctc gttcatcggg acttggcagc 2820
cagaaacatc ctggtagctg aggggcggaa gatgaagatt tcggatttcg gcttgtcccg 2880
agatgtttat gaagaggatt cctacgtgaa gaggagccag ggtcggattc cagttaaatg 2940
gatggcaatt gaatcccttt ttgatcatat ctacaccacg caaagtgatg tatggtcttt 3000
tggtgtcctg ctgtgggaga tcgtgaccct agggggaaac ccctatcctg ggattcctcc 3060
tgagcggctc ttcaaccttc tgaagaccgg ccaccggatg gagaggccag acaactgcag 3120
cgaggagatg taccgcctga tgctgcaatg ctggaagcag gagccggaca aaaggccggt 3180
gtttgcggac atcagcaaag acctggagaa gatgatggtt aagaggagag actacttgga 3240
ccttgcggcg tccactccat ctgactccct gatttatgac gacggcctct cagaggagga 3300
gacaccgctg gtggactgta ataatgcccc cctccctcga gccctccctt ccacatggat 3360
tgaaaacaaa ctctatggca tgtcagaccc gaactggcct ggagagagtc ctgtaccact 3420
cacgagagct gatggcacta acactgggtt tccaagatat ccaaatgata gtgtatatgc 3480
taactggatg ctttcaccct cagcggcaaa attaatggac acgtttgata gttaacattt 3540
ctttgtgaaa ggtaatggac tcacaagggg aagaaacatg ctgagaatgg aaagtctacc 3600
ggccctttct ttgtgaacgt cacattggcc gagccgtgtt cagttcccag gtggcagact 3660
cgtttttggt agtttgtttt aacttccaag gtggttttac ttctgatagc cggtgatttt 3720
ccctcctagc agacatgcca caccgggtaa gagctctgag tcttagtggt taagcattcc 3780
tttctcttca gtgcccagca gcacccagtg ttggtctgtg tccatcagtg accaccaaca 3840
ttctgtgttc acatgtgtgg gtccaacact tactacctgg tgtatgaaat tggacctgaa 3900
ctgttggatt tttctagttg ccgccaaaca aggcaaaaaa atttaaacat gaagcacaca 3960
cacaaaaaag gcagtaggaa aaatgctggc cctgatgacc tgtccttatt cagaatgaga 4020
gactgcgggg ggggcctggg ggtagtgtca atgcccctcc agggctggag gggaagaggg 4080
gccccgagga tgggcctggg ctcagcattc gagatcttga gaatgatttt ttttaaatca 4140
tgcaaccttt ccttaggaag acatttggtt ttcatcatga ttaagatgat tcctagattt 4200
agcacaatgg agagattcca tgccatcttt actatgtgga tggtggtatc agggaagagg 4260
gctcacaaga cacatttgtc ccccgggccc accacatcat cctcacgtgt tcggtactga 4320
gcagccacta cccctgatga gaacagtatg aagaaagggg gctgttggag tcccagaatt 4380
gctgacagca gaggctttgc tgctgtgaat cccacctgcc accagcctgc agcacacccc 4440
acagccaagt agaggcgaaa gcagtggctc atcctacctg ttaggagcag gtagggcttg 4500
tactcacttt aatttgaatc ttatcaactt actcataaag ggacaggcta gctagctgtg 4560
ttagaagtag caatgacaat gaccaaggac tgctacacct ctgattacaa ttctgatgtg 4620
aaaaagatgg tgtttggctc ttatagagcc tgtgtgaaag gcccatggat cagctcttcc 4681
tgtgtttgta atttaatgct gctacaagat gtttctgttt cttagattct gaccatgact 4741
cataagcttc ttgtcattct tcattgcttg tttgtggtca cagatgcaca acactcctcc 4800
agtcttgtgg gggcagcttt tgggaagtct cagcagctct tctggctgtg ttgtcagcac 4860
tgtaacttcg cagaaaagag tcggattacc aaaacactgc ctgctcttca gacttaaagc 4920
actgatagga cttaaaatag tctcattcaa atactgtatt ttatataggc atttcacaaa 4980
aacagcaaaa ttgtggcatt ttgtgaggcc aaggcttgga tgcgtgtgta atagagcctt 5040
gtggtgtgtg cgcacacacc cagagggaga gtttgaaaaa tgcttattgg acacgtaacc 5100
tggctctaat ttgggctgtt tttcagatac actgtgataa gttcttttac aaatatctat 5160
agacatggta aacttttggt tttcagatat gcttaatgat agtcttacta aatgcagaaa 5221
taagaataaa ctttctcaaa ttattaaaaa tgcctacaca gtaagtgtga attgctgcaa 5281
caggtttgtt ctcaggaggg taagaactcc aggtctaaac agctgaccca gtgatgggga 5340
atttatcctt gaccaattta tccttgacca ataacctaat tgtctattcc tgagttataa 5400
aagtccccat ccttattagc tctactggaa ttttcataca cgtaaatgca gaagttacta 5460
agtattaagt attactgagt attaagtagt aatctgtcag ttattaaaat ttgtaaaatc 5520
tatttatgaa aggtcattaa accagatcat gttccttttt ttgtaatcaa ggtgactaag 5580
aaaatcagtt gtgtaaataa aatcatgtat cataaaa                          5617


<210> SEQ ID NO 17
<211> 1114
<212> PRT
<213> Homo sapiens
<400> 17

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu
                5                   10                  15      
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser
            20                  25                  30         
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr
        35                  40                  45              
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro
    50                  55                  60                  
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu
65                  70                  75                  80 
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr
                85                  90                  95     
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg
            100                 105                 110         
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser
        115                 120                 125            
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg
    130                 135                 140                  
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu
145                 150                 155                 160
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile
                165                 170                 175      
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro
            180                 185                 190         
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu
        195                 200                 205             
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser
    210                 215                 220                 
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
225                 230                 235                 240
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val
                245                 250                 255    
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe
            260                 265                 270         
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys
        275                 280                 285             
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val
    290                 295                 300                 
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro
305                 310                 315                 320 
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn
                325                 330                 335     
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His
            340                 345                 350          
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg
        355                 360                 365                
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro
    370                 375                 380                 
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val
385                 390                 395                 400   
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala
                405                 410                 415     
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala
            420                 425                 430         
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn
        435                 440                 445            
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile
    450                 455                 460                  
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
465                 470                 475                 480  
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala
                485                 490                 495    
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu
            500                 505                 510           
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys
        515                 520                 525              
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg
    530                 535                 540                 
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro
545                 550                 555                 560    
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln
                565                 570                 575     
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly
            580                 585                 590         
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr
        595                 600                 605                
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp
    610                 615                 620                 
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala
625                 630                 635                 640 
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys
                645                 650                 655       
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala
            660                 665                 670        
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser
        675                 680                 685            
Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val
    690                 695                 700                 
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
705                 710                 715                 720 
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly
                725                 730                 735      
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr
            740                 745                 750         
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu
        755                 760                 765              
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His
    770                 775                 780                
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu
785                 790                 795                 800
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu
                805                 810                 815      
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser
            820                 825                 830         
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met
        835                 840                 845               
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr
    850                 855                 860                
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile
865                 870                 875                 880
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser
                885                 890                 895       
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg
            900                 905                 910         
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr
        915                 920                 925              
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
    930                 935                 940                 
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
945                 950                 955                 960      
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys
                965                 970                 975    
Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro
            980                 985                 990        
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met
        995                 1000                1005           
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser
    1010                1015                1020               
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu
1025                1030                1035                1040
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp
                1045                1050                1055    
Ile Glu Asn Lys Leu Tyr Gly Met Ser Asp Pro Asn Trp Pro Gly Glu
            1060                1065                1070        
Ser Pro Val Pro Leu Thr Arg Ala Asp Gly Thr Asn Thr Gly Phe Pro
        1075                1080                1085            
Arg Tyr Pro Asn Asp Ser Val Tyr Ala Asn Trp Met Leu Ser Pro Ser
    1090                1095                1100               
Ala Ala Lys Leu Met Asp Thr Phe Asp Ser
1105                1110                   
